Halofantrine

This page contains recent news articles, when available, and an overview of Halofantrine but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Halofantrine
(when available)

Pharmacology and use:
Halofantrine is a synthetic antimalarial which acts as a blood schizonticide. It is effective against multi drug resistant (including mefloquine resistant) P. falciparum malaria. For treatment of Severe malaria

Mechanism Of Action:
The mechanism of action of Halofantrine may be similar to that of chloroquine, quinine, and mefloquine; by forming toxic complexes with ferritoporphyrin IX that damage the membrane of the parasite.

News Articles on Halofantrine

Novartis drug Tasigna(R) meets primary endpoint in pivotal trial against ...  -  ‎Oct 19, 2009‎
...but not limited to chloroquine, halofantrine, clarithromycin, haloperidol, methadone, moxifloxacin, bepridil, and pimozide) should be avoided. ... Reuters

Noxafil wins approval for the prevention of invasive Aspergillus,...  -  Nov 1, 2006
Coadministration is contraindicated for ergot alkaloids, terfenadine, astemizole, cisapride, pimozide, halofantrine, and quinidine. ... Free with registration - Internal Medicine News - AccessMyLibrary.com

Malaria kills one child every 30 seconds worldwide, and Kyle Webster ...  -  Jun 5, 2005
Then the second drug, halofantrine, fails. If Webster doesn't find a ... Halofantrine exhibited cardiovascular side effects, and mefloquine showed adverse ... San Francisco Chronicle

Special to CNN.com  -  Aug 7, 2006
Doctors sometimes use halofantrine for treatment of malaria, although it's not marketed in the United States. If you've been taking mefloquine for ... cnn.com

SRI International Celebrates 50 Years of Drug Discovery and …  -  Jun 20, 2005
In the 1970s, SRI developed halofantrine for the US Army as a treatment for ... The Food and Drug Administration (FDA) approved halofantrine as an ... $4.95 - Business Wire - ECNext

Pharmacologic agents associated with QT interval prolongation.  -  Jun 1, 2005
Sertindole Halofantrine (antimalarial) Thioridazine Indapamide, moexipril Chlorpromazine (antihypertensive) Ketoconazole (antifungal) ... Pay-Per-View - Journal of Family Practice - Factiva, from Dow Jones

Impact of lipoproteins on the biological activity and disposition of ...  -  Feb 1, 2007
Examples of drugs with high log P values that are known to bind to lipoproteins include cyclosporine A, amiodarone, halofantrine, amphotericin B, ... Nature.com

Pharmacologic agents associated with QT interval prolongation.  -  Jun 1, 2005
...(11,29) In addition, some medications of unrelated classes, such as arsenic trioxide, cisapride, dolasetron, foscarnet, halofantrine, indapamide, ... $4.95 - Journal of Family Practice - ECNext

Genetic linkage of pfmdr1 with food vacuolar solute import in...  -  Jun 22, 2006
...of 100 nM of chloroquine (CQ), mefloquine (MQ), halofantrine (HF), quinine (QN) or artemisinin (ART) and Fluo-4 R vac/cyt ratios were determined. ... Nature.com

为什么å?¬æˆ‘们的?  -  Jul 25, 2007
Halofantrine抗疟疾�剂,治疗世界上最致命的传染病疟疾的��,这�是我们�与研� 的众多��中的一�,�外还包括一些治疗爱滋病和癌症的��。 ... 腾讯网

Literature-based evaluation of four 'hard endpoint' models for...  -  Jul 7, 2008
Proarrhythmic potential of halofantrine, terfenadine, and clofilium in a modified in vivo model of torsade de pointes. Br J Pharmacol 135: 1003–1012. ... Nature.com

SRI International Awarded Defense Threat Reduction Agency (DTRA) …  -  Sep 22, 2008
SRI's research successes in anti-infectives include halofantrine, which is a marketed drug used to treat malaria, and vidarabine, which is an antiviral drug ... marketwire.com

The New England Journal Of Medicine Publishes Two Landmark Studies …  -  Jan 25, 2007
Co-administration with the CYP3A4 substrates terfenadine, astemizole, cisapride, pimozide, halofantrine or quinidine, is contraindicated since this may ... Free with registration - PR Newswire - AccessMyLibrary.com

Cameroun: Paludisme : halte à la monothérapie  -  May 23, 2006
Pour l'instant, ces médicaments, fabriqués à base d'une unique molécule: l'amodiaquine, artéméther, artésunate, halofantrine, etc. seront progressivement ... AllAfrica.com - allafrica.com

Une plante chinoise contrele paludisme  -  Nov 26, 2005
Au Walter Reed Institute de Washington, qui dépend de l'armée américaine, deux nouvelles molécules, la méfloquine et l'halofantrine, sont alors mises au ... €2.00 - LE MONDE - Le Monde Interactif

SRI Boasts Abilities in Early- and Late-Stage R&D  -  Aug 1, 2008
The first drug that SRI ever helped to send to market was halofantrine, an antimalarial compound. In late 2007, the National Institute of Allergy and ... Genetic Engineering News - Genetic Engineering News (press release)

SRI International and Telik Announce Exclusive License for SRI to …  -  Feb 8, 2007
Marketed examples of these drugs include bexarotene and halofantrine. Additionally, working with government and industry partners, SRI has helped advance ... Free with registration - PR Newswire - AccessMyLibrary.com

Schering-Plough Announces FDA Approval of NOXAFIL(R) ( …  -  Oct 23, 2006
Co-administration with the CYP3A4 substrates terfenadine, astemizole, cisapride, pimozide, halofantrine or quinidine is contraindicated since this may ... Free with registration - PR Newswire - AccessMyLibrary.com

SRI International Executives Lead Seminar on Collaborative Drug …  -  Sep 12, 2007
Marketed examples of these drugs include Targretin([R]) (bexarotene) and Halfan([R]) (halofantrine). Working with government and industry partners, ... Free with registration - Business Wire - AccessMyLibrary.com

European Union's CHMP Adopts Positive Opinion for Noxafil(R) ( …  -  Sep 22, 2006
Co-administration with the CYP3A4 substrates terfenadine, astemizole, cisapride, pimozide, halofantrine or quinidine is contraindicated since this may ... DG News

SRI International Reacquires Rights to Tirapazamine, a Phase III...  -  May 7, 2007
Marketed examples of these drugs include Targretin(R) (bexarotene) and Halfan(R) (halofantrine). Additionally, working with government and industry partners ... Genetic Engineering News - Genetic Engineering News (press release)

One in seven drugs fake worldwide, claims report  -  Mar 14, 2005
For example, in December of 2000, Belgian customs seized 57600 packs of fake Halfan (halofantrine) capsules, an antimalarial sold by GlaxoSmithKline - en ... In-PharmaTechnologist.com

SRI International to Conduct Preclinical Studies of Cancer Drug for …  -  Oct 3, 2006
Marketed examples of these drugs include bexarotene and halofantrine. Additionally, working with government and industry partners, SRI has helped advance ... Genetic Engineering News - Genetic Engineering News (press release)

SRI International Awarded DARPA Subcontract to Accelerate Vaccine …  -  Jul 17, 2007
Marketed examples of these drugs include Targretin[R] (bexarotene) and Halfan[R] (halofantrine). Additionally, working with government and industry partners ... Free with registration - Business Wire - AccessMyLibrary.com

Malaria in pregnancy  -  Jan 1, 2005
Drugs in this class approved in the US include chloroquine, quinidine, hydroxychloroquine and the newer aminoquinolones, mefloquine and halofantrine. ... Free with registration - Infectious Diseases in Obstetrics and... - AccessMyLibrary.com

Travel to Malaria-Endemic Areas Requires a Mosquito Map  -  Nov 8, 2006
Halfan (halofantrine) and Fansidar (sulfadoxine-pyrimethamine) are not recommended because of fatal adverse events. "Because of the concern for resistance ... MedPage Today

SRI International Announces New Manager of Operations for Quality …  -  Feb 13, 2007
Marketed examples of these drugs include bexarotene and halofantrine. Additionally, working with government and industry partners, SRI has helped advance ... Genetic Engineering News - Genetic Engineering News (press release)

International Approvals: Byetta and Noxafil  -  Nov 28, 2006
Concomitant use of posaconazole with the cytochrome-P450 3A4 (CYP3A4) substrates terfenadine, astemizole, cisapride, pimozide, halofantrine, or quinidine is ... Medscape

SRI International Awarded National Institute of Allergy and Infectious...  -  Aug 16, 2007
Marketed examples of these drugs include Targretin(R) (bexarotene) and Halfan(R) (halofantrine). Additionally, working with government and industry partners ... Genetic Engineering News - Genetic Engineering News (press release)

SRI International Awarded National Institute of Allergy and Infectious...  -  May 18, 2006
Marketed examples of these drugs include bexarotene and halofantrine. Additionally, working with government and industry partners, SRI has helped advance ... Genetic Engineering News - Genetic Engineering News (press release)

Blackwater fever in children, Burundi.(DISPATCHES)  -  Jul 1, 2005
Isolated cases have also been described with other antimalarials, such as halofantrine and mefloquine, which belong to the amino-alcohol drug family (3 5). ... $4.95 - Emerging Infectious Diseases - ECNext

New Cancer Practice Guidelines Recommend NOXAFIL(R) ( …  -  Mar 20, 2007
Co-administration with the CYP3A4 substrates terfenadine, astemizole, cisapride, pimozide, halofantrine or quinidine, is contraindicated since this may ... Free with registration - PR Newswire - AccessMyLibrary.com

Biotechnology and Pharmaceutical Executives to Convene at SRI …  -  Oct 12, 2005
Marketed examples of these drugs include bexarotene and halofantrine. Additionally, working with government and industry partners, SRI has helped advance ... $4.95 - Business Wire - ECNext

Promising Cancer Therapeutics Developed by SRI International.  -  Jun 1, 2007
Marketed examples of these drugs include Targretin([R]) (bexarotene) and Halfan([R]) (halofantrine). Additionally, working with government and industry ... Free with registration - Business Wire - AccessMyLibrary.com

SRI International Biosciences Executives to Present Seminar on …  -  Sep 11, 2006
Marketed examples of these drugs include bexarotene and halofantrine. Additionally, working with government and industry partners, SRI has helped advance ... Newswit.com

SRI International Awarded a Multimillion Dollar Contract from the...  -  Nov 7, 2006
Marketed examples of these drugs include bexarotene and halofantrine. Additionally, working with government and industry partners, SRI has helped advance ... Genetic Engineering News - Genetic Engineering News (press release)

How to take Ziprasidone from Consumer Reports Health.  -  Jan 4, 2007
...erythromycin (EES, E-Mycin, Erythrocin), gatifloxacin (Tequin)(no longer available in the US), halofantrine (Halfan)(no longer available in the US), ... consumerreports.org

Krishna Kodukula Joins SRI International's Biosciences Division  -  May 24, 2006
Marketed examples of these drugs include bexarotene and halofantrine. Additionally, working with government and industry partners, SRI has helped advance ... Genetic Engineering News - Genetic Engineering News (press release)

SRI International And Telik Announce Exclusive License For SRI To …  -  Feb 9, 2007
Marketed examples of these drugs include bexarotene and halofantrine. Additionally, working with government and industry partners, SRI has helped advance ... Medical News Today - Medical News Today (press release)

Une plante chinoise contre le paludisme  -  Dec 5, 2005
Au Walter Reed Institute de Washington, qui dépend de l'armée américaine, deux nouvelles molécules, la méfloquine et l'halofantrine, sont alors mises au ... Chine-informations.com

SRI International Launches Center of Excellence in Infectious Disease...  -  Jan 18, 2006
...on SRI's many years of experience and success in the field of drug development for infectious diseases as exemplified by the anti-malarial halofantrine. ... RedOrbit

Investigation Into the Criminal Fake Artesunate Trade in South East...  -  Aug 5, 2007
For example, cooperation between the Belgian and Chinese authorities resulted in the interception of 57000 packs of counterfeit halofantrine capsules en ... Medscape

Journal de Pharmacie Clinique  -  Jan 19, 2005
...en 1992 pour sa thèse « Conséquences de la chiralité sur la pharmacocinétique et l'activité schizonticide de la méfloquine et de l'halofantrine ». ... john-libbey-eurotext.fr

SRI International Awarded Contract From National Institute of …  -  Dec 20, 2006
Marketed examples of these drugs include bexarotene and halofantrine. Additionally, working with government and industry partners, SRI has helped advance ... Free with registration - Business Wire - AccessMyLibrary.com

ANTIHISTAMINE (Oral route, Parenteral route, Rectal route).(Drug …  -  May 1, 2007
Halofantrine * Haloperidol * Halothane * Hydroquinidine * Ibutilide * Imipramine * Isoflurane * Isradipine * Josamycin * Levorphanol * Lidoflazine * Lithium ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Amiodarone Gnr - Indications, Contre indications, Effets indésirables  -  Sep 14, 2005
Ce médicament EST GENERALEMENT DECONSEILLE en association avec le diltiazem injectable ainsi qu'avec l'halofantrine et la pentamidine (voir interactions). ... Santé AZ

Counterfeit drug racket  -  Feb 4, 2006
Well, it's extremely dangerous if there's no halofantrine in the stuff. Robert Cockburn: Dr Newton researches the extent of fake malaria drugs in south east ... ABC Regional Online - ABC Regional Online

Ziprasidone (Systemic).(Drug overview)  -  Aug 1, 2006
Inapsine) or Gatifloxacin (eg, Tequin) or Halofantrine (eg, Halfan) or Levomethadyl acetate (eg, Orlaam) or Mefloquine (eg, Lariam) or Mesoridazine (eg, ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

FLUOROQUINOLONE (Oral route, Injection route, Intravenous route).( …  -  May 1, 2007
Halofantrine * Haloperidol * Hydroquinidine * Ibutilide * Imipramine * Insulin * Insulin Aspart, Recombinant * Insulin Glulisine ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

SRI International Biosciences Executives to Present Seminar on …  -  Sep 8, 2006
Marketed examples of these drugs include bexarotene and halofantrine. Additionally, working with government and industry partners, SRI has helped advance ... Free with registration - Business Wire - AccessMyLibrary.com

The Seven Plagues of the XXIst Century  -  Jun 2, 2007
Many treatments have been developed (mefloquine, Halofantrine, Artemisia products) but none has a total effectiveness, as the parasite constantly mutates, ... Softpedia

International Approvals: Accomplia and Noxafil  -  Nov 20, 2006
Coadministration of posaconazole with the cytochrome P450 3A4 (CYP3A4) substrates terfenadine, astemizole, cisapride, pimozide, halofantrine, or quinidine ... Medscape

Top 10 Infectious Diseases That Have Killed Millions of People  -  Nov 13, 2007
Many treatments have been developed (mefloquine, Halofantrine, Artemisia products) but none has a total effectiveness, as the parasite constantly mutates, ... Softpedia

Malaria; Research findings from , India and France update understandin...  -  Jan 1, 2007
...des Armees in Marseille, "In vitro activities of chloroquine, quinine, cycloguanil, atovaquone, mefloquine, halofantrine, and artesunate were evaluated. ... Pay-Per-View - Malaria Weekly - Factiva, from Dow Jones

Noxafil: posaconazole oral suspension.(New molecular entities)  -  Oct 1, 2006
Posaconazole should not be coadministered with ergot alkaloids or the CYP3A4 substrates terfenadine, astemizole, cisapride, pimozide, halofantrine, ... $4.95 - Formulary - ECNext

SRI Int opens center of excellence in infectious disease, biodefense.(...  -  Jan 30, 2006
...on SRI's many years of experience and success in the field of drug development for infectious diseases as exemplified by the anti-malarial halofantrine. ... $4.95 - Pharma Marketletter - ECNext

A review of the new antifungals: posaconazole, micafungin, and …  -  Dec 1, 2007
...halofantrine (Halfan[R], pimozide (Orap[R], quinidine (Cardioquin[R] Quinidex[R] Quinaglute Dura Tabs[R], terfenadine (Seldane[R], ergot medicines such ... $4.95 - Journal of Drugs in Dermatology - ECNext

Article: Posaconazole approved for fungal infections.(News) - Skin & ...  -  Nov 1, 2006
Coadministration is contraindicated for ergot alkaloids, terfenadine, astemi zole, cisapride, pimozide, halofantrine, and quinidine. ... Pay-Per-View - Skin & Allergy News - HighBeam Research

Georgia Code - 16-13-71. (a) A "dangerous drug" means any drug other ...  -  Aug 4, 2005
...(433) Halcinonide; (433.5) Halobetasol Propionate; (433.7) Halofantrine; (434) Haloperidol; (435) Haloprogin; (436) Halothane; (437) Hartman's solution; ... Pay-Per-View - Georgia Code - Loislaw

Brand Names/Synonyms:
Halofantrine is also known by the following brand names and/or synonymsHalfan; Halofantrina; Halofantrina [Inn-Spanish]; Halofantrine; Halofantrine [Usan]; Halofantrinum; Halofantrinum [Inn-Latin]

Drug Category:
Halofantrine is categorized under the following by the FDA: Antimalarials; ATC:P01BX01

Dosage Forms:
TABLET

Absorption:
Not Available

Interactions:
Not Available



Chemical IUPAC Name:
3-dibutylamino-1-[1,3-dichloro-6-(trifluoromethyl)phenanthren-9-yl]-propan-1-ol





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