Hyaluronidase

This page contains recent news articles, when available, and an overview of Hyaluronidase but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Hyaluronidase
(when available)

Pharmacology and use:
Hyaluronidase hydrolyzes hyaluronic acid by splitting the glucosaminidic bond between C1 of the glucosamine moiety and C4 of glucuronic acid. This temporarily decreases the viscosity of the cellular cement and promotes diffusion of injected fluids or of localized transudates or exudates, thus facilitating their absorption. Enhances absorption and distribution of drugs and anesthetics, Also used for rehydration

Mechanism Of Action:
Hydrolyzes hyaluronic acid by splitting the glucosaminidic bond between C1 of the glucosamine moiety and C4 of glucuronic acid.

News Articles on Hyaluronidase

Antiaging ingredients to look out for in 2010  -  ‎Jan 3, 2010‎
As well as being a Japanese super-food, phytessence wakame has demonstrated dose-dependent inhibition of the activity of hyaluronidase in vitro. ... Truth In Aging (blog)

prometic and Halozyme Enter Into Long-Term Supply Agreement  -  14 Nov 2009
Hyaluronidase temporarily degrades hyaluronan, a space-filling, gel-like substance that is an important structural component of tissues throughout the body, ... PR-USA.net (press release)

ProMetic Reports Its Third Quarter 2009 Highlights and Financial Results  -  14 Nov 2009
...to provide a synthetic ligand affinity adsorbent for use in the manufacture of its rHuPH20 product, a recombinant version of human hyaluronidase enzyme. ... SYS-CON Media (press release)

ProMetic Reports Its Third Quarter 2009 Highlights and Financial Results  -  14 Nov 2009
...to provide a synthetic ligand affinity adsorbent for use in the manufacture of its rHuPH20 product, a recombinant version of human hyaluronidase enzyme. ... eMediaWorld.com Newswire Press Release Distribution Service (press release)

prometic annonce les points saillants et ses résultats financiers pour le ...  -  14 Nov 2009
...conçu à partir d'un ligand synthétique pour la fabrication du produit rhuph20, une version de l'enzyme hyaluronidase recombinée pour l'humain. ... Maketwire (Communiqué de presse)

Ista boosts production of hyaluronidase injection due to shortage  -  ‎Oct 19, 2009‎
..."Ista Pharmaceuticals increased its production to assist the clinical community in maintaining continuous supplies of high quality commercial hyaluronidase ... OSN SuperSite

Enzymatic digestion of articular cartilage results in viscoelasticity changes ...  -  ‎Nov 4, 2009‎
Bovine calf cartilage explants were cultured overnight before being immersed in type IV collagenase, bacterial hyaluronidase, or control solutions. ... 7thSpace Interactive (press release)

ProMetic Life Sciences signs supply agreement with Halozyme Therapeutics  -  ‎Nov 9, 2009‎
...provided under the supply agreement is used by Halozyme in the manufacture of its rHuPH20 product, a recombinant version of human hyaluronidase enzyme. Trading Markets (press release)

Medical:Flu Season-Options for rehydrating your kids  -  ‎Nov 2, 2009‎
Hylenex is made from hyaluronidase, an enzyme that breaks down hyaluronan (hyaluronic acid, an enzyme that holds cells together, like glue, ... WCBD

Halozyme Therapeutics Reports Third Quarter 2009 Financial Results  -  ‎Nov 6, 2009‎
Baxter, Halozyme's licensee, launched Hylenex (hyaluronidase human injection) in early October at the scientific assembly of the American College of ... WELT ONLINE

Subcutaneous Rehydration Useful Alternative in Kids  -  ‎Oct 28, 2009‎
..."The study included 51 children admitted to emergency rooms throughout the country who were given Hylenex (hyaluronidase human injection-Baxter)," says ... The Hospitalist Online

ISTA Pharmaceuticals Inc. Reports Operating Results (10-Q)  -  ‎Nov 5, 2009‎
The company's product development efforts involve mixtures of a natural enzyme called hyaluronidase. The company targets serious conditions of the eye such ... GuruFocus.com

ISTA Pharmaceuticals Reports Third Quarter 2009 Financial Results  -  ‎Nov 4, 2009‎
Istalol® (timolol maleate ophthalmic solution) 0.5%, and Vitrase® (hyaluronidase injection) are trademarks of ISTA Pharmaceuticals. CNNMoney.com (press release)

From boob jobs to wrinkle fillers, I've had £30000 of beauty treatments - and ...  -  ‎Nov 11, 2009‎
Luckily, Restylane is made from hyaluronic acid which can be dissolved by injecting it with an enzyme called hyaluronidase, though that means more ... Daily Mail

ISTA Pharmaceuticals Reports Third Quarter 2009 Financial Results  -  ‎Nov 3, 2009‎
Istalol® (timolol maleate ophthalmic solution) 0.5%, and Vitrase® (hyaluronidase injection) are trademarks of ISTA Pharmaceuticals. ... Reuters

Do eye rollers work  -  ‎Nov 11, 2009‎
This is a saponin from the seeds of horse chestnut and it is supposed to strengthen veins and capillaries by blocking an enzyme called hyaluronidase. ... Truth In Aging (blog)

ProMetic Life Sciences and Halozyme sign supply agreement  -  ‎Nov 11, 2009‎
...provided under the supply agreement is used by Halozyme in the manufacture of its rHuPH20 product, a recombinant version of human hyaluronidase enzyme. ... Trading Markets (press release)

Under-skin rehydration injection safe, effective, less painful for children in ER  -  ‎Oct 20, 2009‎
The experimental injection is aided by the enzyme hyaluronidase, a genetically-altered spreading agent that helps increase the body's ability to transmit ... The Virtual Medical Centre

Clinic Roundup  -  ‎Nov 9, 2009‎
...variability for the combination of lispro, a meal-time analogue insulin, plus PH20 (hyaluronidase) compared to subcutaneous injection of lispro alone. ... Therapeutics Daily (press release) (registration)

Halozyme Announces Roche Doses First Patient in Phase 3 Clinical Trial with ...  -  ‎Oct 21, 2009‎
Enhanze technology (rHuPH20, recombinant human hyaluronidase) in a subcutaneous formulation with Roche`s anticancer biologic, Herceptin (trastuzumab). ... Reuters

Ista narrows net loss, reports 47% revenue spike for third quarter  -  ‎Nov 6, 2009‎
Revenue from sales of Istalol (timolol maleate ophthalmic solution 0.5%) rose 31% to $5.1 million, while revenue from sales of Vitrase (hyaluronidase) ... OSN SuperSite

Halozyme Study Results Show Faster Insulin Absorption when Administered in ...  -  ‎Oct 21, 2009‎
...concentrations after co-administration of its recombinant hyaluronidase enzyme (rHuPH20 or PH20) with regular human insulin and with insulin lispro. ... Reuters

New Uses for a Stalwart of Korean Cuisine  -  ‎Oct 23, 2009‎
The experiment proved it can alleviate inflammation by controlling activation of hyaluronidase, the enzyme that dissolves hyaluronic acid, as well as its ... 조선일보(영문판)

ProMetic conclut une entente d'approvisionnement à long terme avec Halozyme  -  ‎Nov 9, 2009‎
L'hyaluronidase dégrade temporairement l'hyaluronane, une substance semblable au gel et servant de remplissage, qui est un élément de structure important ... Maketwire (Communiqué de presse)

Halozyme Therapeuticså?‘表胰岛素实验结果  -  ‎Oct 22, 2009‎
...(HALO) 7.36 : Halozyme Therapeutics宣布,剂é‡?å??应研究结果显示,å?ˆå¹¶æ–½ç”¨é‡?组hyaluronidase酵素(rHupH20或PH20)或正常人类胰岛素浓缩物後,胰岛素的å?¸æ”¶æ›´å¿«ï¼Œä¹Ÿ ... 凤凰网

ì?˜ë£Œê³„ì?˜ 나침반…제8회 IMEX 2009'  -  ‎Oct 26, 2009‎
...그리고 '비만체형 ë°? 미용성형'ì—?서는 â–²PPC주사를 활용한 안면축소술 â–²LLD(Hyaluronidase)를 활용한 복부비만ì?˜ 치료 â–²CCR (Cavitation, Canula dissection, ... 메디컬헤럴드

Dynamic study of the transition from hyaluronan- to integrin-mediated...  -  Jan 12, 2006
...(B) Hyaluronidase treatment of the same cells leads to a major reduction in the ... (E) Hyaluronidase-treated cells develop significantly less small ... Nature.com

Vitrase (Hyaluronidase Injection) Now Available to US Ophthalmologists  -  Jan 6, 2005
IRVINE, CA -- January 6, 2005 -- ISTA Pharmaceuticals, Inc. (Nasdaq: ISTA) today announced ISTA's United States market launch of Vitrase® (hyaluronidase ... DG News

The effect of hyaluronidase on ultrasound-measured dispersal of local...  -  May 25, 2007
Correspondence: M Khandwala, 5 College Close, Lingfield, Surrey RH7 6HG, UK. Tel: +07 941 604 630; Fax: +01 342 837 784; E-mail: mona.khandwala@gmail.com ... Nature.com

Halozyme says Chemophases meets primary endpoint in Phase I/IIa trial  -  Jun 30, 2008
Based on the results, the Chemophase combination treatment of mitomycin plus the recombinant human hyaluronidase enzyme was 'well tolerated and appears safe ... Forbes

… Marks the First Recombinant Human Hyaluronidase Approved for Use...  -  Dec 5, 2005
SAN DIEGO, CA, and DEERFIELD, IL -- December 5, 2005 -- Halozyme Therapeutics, Inc. and Baxter Healthcare Corporation announced today that the US Food and ... DG News

Pure hyaluronidase beats compound for correction.(Dermatologic …  -  Jun 1, 2007
PHOENIX -- Consider keeping hyaluronidase for injection on hand for repairing problems caused by hyaluronic acid fillers and not relying on compounded forms ... Free with registration - Skin & Allergy News - AccessMyLibrary.com

… Injection of Vitrase (Ovine Hyaluronidase) Results in Improved...  -  Nov 4, 2005
ISTA's Vitrase(R) is a proprietary formulation of highly purified ovine hyaluronidase. In May 2004, the FDA approved Vitrase(R) in a lyophilized 6200 USP ... DG News

Hyaluronan accumulates in demyelinated lesions and inhibits …  -  Aug 7, 2005
Hyaluronidase (HA-dase)-treated cultures showed a marked increase in MBP + oligodendrocytes (middle) as compared to the untreated control cultures (middle ... Nature.com

… of ISTA's European Marketing Application for Ovine Hyaluronidase fo  -  Jan 12, 2006
Vitragan is ISTA's proprietary formulation of highly purified ovine hyaluronidase which is commonly known in the US as Vitrase(R). ... RedOrbit

Halozyme Therapeutics and Baxter Present Promising Results for the...  -  Feb 14, 2007
HYLENEX recombinant (hyaluronidase human injection) is indicated as an adjuvant to ... Hyaluronidase is contraindicated in patients with hypersensitivity to ... RedOrbit

Halozyme Therapeutics Initiates First Enhanze Technology Clinical...  -  Aug 8, 2006
As a spreading agent, hyaluronidase has traditionally been used to accelerate the delivery of drugs and fluids, including local anesthetics, ... Free with registration - PR Newswire - AccessMyLibrary.com

Pure hyaluronidase beats compound for correction.(Dermatologic …  -  Jun 1, 2007
Pure hyaluronidase beats compound for correction.(Dermatologic Surgery) ... find Skin & Allergy News articles. PHOENIX -- Consider keeping hyaluronidase for ... Pay-Per-View - Skin & Allergy News - HighBeam Research

hyaluronidase (enzyme) -- Britannica Online Encyclopedia  -  Jun 16, 2008
Britannica online encyclopedia article on hyaluronidase (enzyme), any of a group of enzymes that catalyze the hydrolysis (chemical decomposition involving ... Subscription - Encyclopedia Britannica

Halozyme's hyaluronidase enhances chemotherapy.(product …  -  May 2, 2005
The USA's Halozyme Therapeutics, a development-stage biopharmaceutical company focused on recombinant human enzymes, says that results from new preclinical ... $4.95 - Pharma Marketletter - ECNext

Research Supports Effectiveness Of Biocell Collagen II(r) In Promoting...  -  Jan 19, 2006
By inhibiting hyaluronidase, levels of HA in the skin can increase, reducing wrinkling while enhancing natural collagen production. ... npicenter.com

Halozyme Therapeutics Announces rHuPH20 Hyaluronidase Preclinical …  -  Apr 18, 2005
WASHINGTON, April 18 /PRNewswire-FirstCall/ -- Halozyme Therapeutics, Inc. , a development stage biopharmaceutical company focused on the development and ... $4.95 - PR Newswire - ECNext

Hyaluronidase May Boost, Speed Morphine's Effect: Presented at AAHPM  -  Feb 28, 2007
By Bonnie Darves. SALT LAKE CITY, UT -- February 28, 2007 -- In hospice patients with moderate to severe pain, subcutaneous (SC) human recombinant enzyme ... DG News

Granulomatous Inflammation After Hylan GF 20 Viscosupplementation of ...  -  Jul 1, 2006
The authors stated that the pink material was stained with alcian blue and that the alcian blue material was dissolved by hyaluronidase. ... Journal of Bone and Joint Surgery - Journal of Bone and Joint Surgery...

… Therapeutics Presents rHuPH20 Hyaluronidase Preclinical Data at...  -  Apr 19, 2005
ANAHEIM, Calif. and SAN DIEGO, April 19 /PRNewswire-FirstCall/ -- Halozyme Therapeutics, Inc. , a development stage biopharmaceutical company focused on the ... RedOrbit

… dosing to subcutaneous dosing with recombinant human hyaluronidase.  -  Oct 1, 2007
The transient degradation of hyaluronic acid with hyaluronidase represents a ... The discovery of the human hyaluronidase gene family and the molecular ... $9.94 - Pharmaceutical Technology - Alacra Store

BioCell Collagen II shown to inhibit hyaluronidase.(American Institute...  -  Mar 1, 2006
BioCell Collagen II shown to inhibit hyaluronidase.(American Institute for Biosocial and Medical Research, Inc)(Brief article) ... find Nutraceuticals World ... Pay-Per-View - Nutraceuticals World - HighBeam Research

Baxter Chooses Halozyme Again; Firms Collaborate On SC IVIG  -  Sep 11, 2007
Also based on the hyaluronidase platform, Chemophase is a chemoadjuvant aimed at improving the delivery of chemotherapy to previously chemo-refractory ... BioWorld Online - BioWorld Online

Assisted Reproduction; Anti-hyaluronidase oligosaccharide analyzed, …  -  Mar 21, 2005
2005 MAR 21 - (NewsRx.com) -- According to recent research from Japan published in the journal Biology of Reproduction, anti-hyaluronidase oligosaccharide ... Pay-Per-View - OBGYN & Reproduction Week - Factiva, from Dow Jones

hyaluronidase (human recombinant) Halozyme phase change II, USA ( …  -  May 8, 2006
Halozyme announced on 26 April 2006 that it has initiated a US phase I/IIa trial of hyaluronidase (human recombinant) (CHEMOPHASE), a recombinant ... Pay-Per-View - R & D Focus Drug News - Factiva, from Dow Jones

University of Ryukyus, Okinawa; Anti-hyaluronidase oligosaccharide …  -  Mar 23, 2005
2005 MAR 23 - (NewsRx.com) -- According to recent research from Japan published in the journal Biology of Reproduction, anti-hyaluronidase oligosaccharide ... Pay-Per-View - Biotech Week - Factiva, from Dow Jones

Press Release: Halozyme Therapeutics Announces 22% Increase in IVF …  -  May 4, 2006
...rHuPH20 (recombinant human PH20 hyaluronidase ... SynVitro Cumulase are the first and only recombinant human hyaluronidase ... products: Cumulase(R), ... Pay-Per-View - PR Newswire - HighBeam Research

Halozyme Therapeutics receives FDA clearance for Cumulase  -  Apr 20, 2005
The active pharmaceutical ingredient in Cumulase is the first and only recombinant human hyaluronidase approved in the United States for cumulus removal in ... News-Medical.net

BAXTER UNVEILS HYLENEX FOR OPHTHALMIC SURGERY.  -  Jun 1, 2007
HYLENEX is the first and only human recombinant hyaluronidase ... "The incorporation of animal-derived hyaluronidase into the anesthetic protocol for ... Free with registration - Biotech Business - AccessMyLibrary.com

Halozyme Therapeutics Completes Enrollment of Infuse-Morphine …  -  Oct 10, 2006
Hylenex recombinant (hyaluronidase human injection) is indicated for use as an adjuvant to increase the absorption and dispersion of other injected drugs; ... $4.95 - PR Newswire - ECNext

… Therapeutics Presents rHuPH20 Hyaluronidase Preclinical Data at...  -  May 2, 2005
Halozyme Therapeutics Presents rHuPH20 Hyaluronidase Preclinical Data at the 2005 Association for Research in Vision and Ophthalmology Annual Meeting. from ... Pay-Per-View - PR Newswire - HighBeam Research

Delayed presentation of impending necrosis following soft tissue …  -  Mar 1, 2007
The injection technique of multiple stabs of hyaluronidase along the course ... Follow-up examination after the hyaluronidase injection was day 6 from the ... Free with registration - Journal of Drugs in Dermatology - AccessMyLibrary.com

Press Release: Halozyme Therapeutics Reports 2008 Second Quarter …  -  Aug 8, 2008
HYLENEX recombinant (hyaluronidase human injection) is indicated as an adjuvant to ... Hyaluronidase is contraindicated in patients with hypersensitivity to ... Pay-Per-View - PR Newswire - HighBeam Research

Press Release: Halozyme and Baxter Expand Global HYLENEX …  -  Feb 14, 2007
HYLENEX recombinant (hyaluronidase human injection) is indicated as an adjuvant to ... Hyaluronidase is contraindicated in patients with hypersensitivity to ... Pay-Per-View - PR Newswire - HighBeam Research

… Safety and Tolerability Data for rHuPH20 Hyaluronidase Presented at...  -  Jun 21, 2005
Hyaluronidase that is injected in the skin or in the muscle can temporarily digest the HA gel to enhance the penetration and diffusion of other injected ... $4.95 - PR Newswire - ECNext

Roche to use Halozyme' Enhanze technology.  -  Dec 22, 2006
Enhanze is Halozyme's proprietary drug-delivery technology based on its recombinant human hyaluronidase (rHuPH20). This is an analog of a human enzyme that ... $9.94 - Pharma Marketletter - Alacra Store

Halozyme Therapeutics Reports 2007 Second Quarter Financial Results.  -  Aug 9, 2007
The introduction by Baxter of HYLENEX recombinant (hyaluronidase human injection) ... Hyaluronidase is contraindicated in patients with hypersensitivity to ... Free with registration - PR Newswire - AccessMyLibrary.com

Ophthalmic Conditions; FDA approves single-use vial of Vitrase for...  -  Jan 3, 2005
This approval removed hyaluronidase from the FDA's drug shortage list where it had been listed since 2001. According to the American Academy of ... Pay-Per-View - Biotech Business Week - Factiva, from Dow Jones

Press Release: Halozyme Therapeutics Announces Peer-Reviewed …  -  Jan 8, 2008
Initial Experiences with Subcutaneous Recombinant Human Hyaluronidase (rHuPH20). ... HYLENEX is the first and only FDA-approved hyaluronidase from a ... Pay-Per-View - PR Newswire - HighBeam Research

… Release: Halozyme Therapeutics Announces rHuPH20 Hyaluronidase …  -  Apr 18, 2005
Halozyme Therapeutics Announces rHuPH20 Hyaluronidase Preclinical Data Presented at the 2005 American Society of Cataract & Refractory Surgery Symposium and ... Pay-Per-View - PR Newswire - HighBeam Research

Halozyme Therapeutics and Baxter Release Results From the INFUSE- …  -  Feb 8, 2006
Hylenex is the first and only FDA-approved hyaluronidase from a recombinant ... Although animal-derived hyaluronidase extracts have been demonstrated in the ... RedOrbit

… Therapeutics Presents rHuPH20 Hyaluronidase Preclinical Data at...  -  Apr 19, 2005
Halozyme Therapeutics Presents rHuPH20 Hyaluronidase Preclinical Data at the 2005 American Association for Cancer Research; - rHuPH20 Enzyme Increases Tumor ... Pay-Per-View - PR Newswire - HighBeam Research

Press Release: Halozyme Therapeutics and Baxter Present Promising …  -  Feb 14, 2007
HYLENEX recombinant is a liquid injectable formulation that includes the active pharmaceutical ingredient, recombinant human hyaluronidase (rHuPH20), ... Pay-Per-View - PR Newswire - HighBeam Research

… rHuPH20.(Halozyme Therapeutics)(recombinant human hyaluronidase)( …  -  Jul 4, 2005
...absence of allergic reactions to its recombinant human hyaluronidase and significantly reduced injection-site discomfort compared to the saline control. ... $4.95 - Pharma Marketletter - ECNext

ISTA widens Q4 loss Los Angeles Business from bizjournals  -  Mar 2, 2005
ISTA (NASDAQ: ISTA) develops drugs based on hyaluronidase, a group of naturally occurring enzymes. Investment firm Sprout Group of New York owns about 25 ... Los Angeles Business

Business Update; Companies ink development and supply agreement for …  -  Apr 26, 2005
Halozyme's hyaluronidase (rHuPH20) is a recombinant form of the naturally ... Hyaluronidase that is injected in the skin or in the muscle is being studied ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

Assisted Reproduction; Biopharmaceutical company receives CE Mark for...  -  Jan 27, 2005
The first recombinant human hyaluronidase (rHuPH20) is being developed by Halozyme as a medical device (Cumulase), drug enhancement agent (Enhanze SC), ... Pay-Per-View - Gene Therapy Weekly - Factiva, from Dow Jones

Halozyme Therapeutics and Baxter Healthcare Corporation Expand …  -  Aug 8, 2005
Hylenex is a local formulation of recombinant human hyaluronidase under development for ... Halozyme's hyaluronidase (rHuPH20) is a recombinant form of the ... $4.95 - PR Newswire - ECNext

허리 수술 최대ì?˜ 난국 '요통 ì¦?후군'  -  Nov 17, 2008
...신경근 차단술� 시행할 때는 여러 가지 약� 혼합해 사용하는� 여러 가지 약제 중� 효과가 좋� 것� 하��제(Hyaluronidase)�는 약물�다. ... 중앙�보 헬스케어

Press Release: Halozyme Therapeutics and Baxter Release Results …  -  Feb 8, 2006
Hylenex is the first and only FDA-approved hyaluronidase from a recombinant ... Although animal-derived hyaluronidase extracts have been demonstrated in the ... Pay-Per-View - PR Newswire - HighBeam Research

Drug Development; US FDA won't meet PDUFA date on Hylenex new …  -  Oct 30, 2005
...with the US Food & Drug Administration (FDA) regarding Halozyme's new drug application (NDA) for Hylenex recombinant (hyaluronidase human injection), ... Pay-Per-View - Medical Letter on the CDC & FDA - Factiva, from Dow Jones

Drug Development; US FDA won't meet PDUFA date on Hylenex new …  -  Oct 25, 2005
...with the US Food & Drug Administration (FDA) regarding Halozyme's new drug application (NDA) for Hylenex recombinant (hyaluronidase human injection), ... Pay-Per-View - Science Letter - Factiva, from Dow Jones

Drug Development; US FDA won't meet PDUFA date on Hylenex new …  -  Oct 24, 2005
...with the US Food & Drug Administration (FDA) regarding Halozyme's new drug application (NDA) for Hylenex recombinant (hyaluronidase human injection), ... Pay-Per-View - Pharma Business Week - Factiva, from Dow Jones

Halozyme and Baxter Announce Availability of Hylenex for Subcutaneous...  -  Jun 27, 2006
Hylenex recombinant (hyaluronidase human injection) is indicated for use as an ... Hyaluronidase has been reported to enhance the adverse events associated ... RedOrbit

Halozyme Therapeutics Reports 2007 Third Quarter Financial Results.  -  Nov 8, 2007
Enhanze Technology is based on recombinant human hyaluronidase (rHuPH20), ... HYLENEX recombinant (hyaluronidase human injection) is indicated as an ... $4.95 - PR Newswire - ECNext

Company Profile Report  -  Dec 6, 2008
...rHuPH20 (Recombinant Human Hyaluronidase Enzyme); HTI-101. Medical Devices ... Hylenex (Recombinant Human Hyaluronidase). Outsourced Services ... $50.00 - Revere Reports - Revere

First American MLS Solutions acquires Maryland Management Sys Inc - …  -  Jan 3, 2006
Vitragan (hyaluronidase [ovine]), #### IU/ml, powder fo r solution for injection. The application for…hyaluro nidase [ovine]), #### IU/ml, ... Pay-Per-View - deals - Alacra Store

Article: BAXTER UNVEILS HYLENEX FOR OPHTHALMIC SURGERY. - …  -  Jun 1, 2007
HYLENEX is the first and only human recombinant hyaluronidase ... "The incorporation of animal-derived hyaluronidase into the anesthetic protocol for ... Pay-Per-View - Biotech Business - HighBeam Research

Press Release: Halozyme Therapeutics Reports 2007 Third Quarter …  -  Nov 8, 2007
Enhanze Technology is based on recombinant human hyaluronidase (rHuPH20), ... HYLENEX recombinant (hyaluronidase human injection) is indicated as an ... Pay-Per-View - PR Newswire - HighBeam Research

Press Release: Halozyme Therapeutics Reports Second Quarter 2006 …  -  Aug 10, 2006
Hylenex recombinant (hyaluronidase human injection) is indicated for use as an ... Hyaluronidase has been reported to enhance the adverse events associated ... Pay-Per-View - PR Newswire - HighBeam Research

Bronchial Tissue Kallikrein Activity Is Regulated by Hyaluronic Acid ...  -  Sep 1, 2008
Hyaluronidase digestion increased TK activity in both pre- and ... Further, after hyaluronidase digestion of media, TK eluted from an anion exchange column ... AJRCMB (subscription)

Marker Shows Promise in Detecting Bladder Carcinoma  -  Apr 6, 2005
NEW YORK APR 06, 2005 (Reuters Health) - Urine levels of hyaluronidase RNA detect ... Hyaluronidase mRNA was detected in 90.8% of patients with malignant ... Cancerpage.com

Press Release: Halozyme Therapeutics Reports Third Quarter 2006 …  -  Nov 9, 2006
Hylenex recombinant (hyaluronidase human injection) is indicated for use as an ... Hyaluronidase has been reported to enhance the adverse events associated ... Pay-Per-View - PR Newswire - HighBeam Research

Halozyme Therapeutics Reports Third Quarter 2006 Financial Results.  -  Nov 9, 2006
Hylenex recombinant (hyaluronidase human injection) is indicated for use as an ... Hyaluronidase has been reported to enhance the adverse events associated ... $4.95 - PR Newswire - ECNext

Press Release: Halozyme Therapeutics Reports Fourth Quarter and Year ...  -  Mar 8, 2007
HYLENEX recombinant (hyaluronidase human injection) is indicated as an adjuvant to ... Hyaluronidase is contraindicated in patients with hypersensitivity to ... Pay-Per-View - PR Newswire - HighBeam Research

Press Release: Halozyme Therapeutics Presents Novel Stroke Data at …  -  Sep 27, 2005
Modified Recombinant Human Hyaluronidase Demonstrates Increased Survival in Preclinical Stroke Models -. SAN DIEGO, Sept. ... Pay-Per-View - PR Newswire - HighBeam Research

Press Release: Halozyme Therapeutics Completes Enrollment of …  -  Nov 27, 2006
As a spreading agent, hyaluronidase has traditionally been used to accelerate the delivery of drugs and fluids, including local anesthetics, ... Pay-Per-View - PR Newswire - HighBeam Research

Halozyme Therapeutics Reports First Quarter 2006 Financial Results.  -  May 10, 2006
Hylenex recombinant (hyaluronidase human injection) is indicated for use as an ... Hyaluronidase has been reported to enhance the adverse events associated ... $4.95 - PR Newswire - ECNext

Press Release: Halozyme Therapeutics Completes Enrollment of Infuse- …  -  Oct 10, 2006
Hylenex recombinant (hyaluronidase human injection) is indicated for use as an adjuvant to increase the absorption and dispersion of other injected drugs; ... Pay-Per-View - PR Newswire - HighBeam Research

ISTA Pharmaceuticals Announces Publication of Vitrase Phase III...  -  Sep 7, 2005
..."The study results suggest a therapeutic utility of ovine hyaluronidase in the management of vitreous hemorrhage," stated Lisa R. Grillone, Ph.D., ... $4.95 - PR Newswire - ECNext

Press Release: Halozyme Therapeutics Releases Results of Enhanze …  -  Jan 22, 2007
As a spreading agent, hyaluronidase has traditionally been used to accelerate ... rHuPH20 is the first and only FDA-approved hyaluronidase from recombinant ... Pay-Per-View - PR Newswire - HighBeam Research

Press Release: Halozyme Therapeutics Reports First Quarter 2006 …  -  May 10, 2006
Hylenex recombinant (hyaluronidase human injection) is indicated for use as an ... Hyaluronidase has been reported to enhance the adverse events associated ... Pay-Per-View - PR Newswire - HighBeam Research

Halozyme Therapeutics Reports Fourth Quarter and Year End 2005 …  -  Mar 23, 2006
The approval of Hylenex recombinant (hyaluronidase human injection) by the US ... Hyaluronidase has been reported to enhance the adverse events associated ... Free with registration - PR Newswire - AccessMyLibrary.com

Merger and Acquisition Scenario  -  Sep 6, 2008
...rHuPH20 (Recombinant Human Hyaluronidase Enzyme); HTI-101; Cumulase (Recombinant Human Hyaluronidase); Chemophase. Target. Qnexa (Phentermine/Topiramate) ... $250.00 - Revere Reports - Revere

Company Profile Report  -  Dec 6, 2008
...rHuPH20 (Recombinant Human Hyaluronidase Enzyme); HTI-101. Medical Devices ... Hylenex (Recombinant Human Hyaluronidase). Outsourced Services ... $50.00 - Revere - Alacra Store

The authors respond.  -  Mar 1, 2007
The package insert for the new product, lyophilized ovine hyaluronidase ... Vitrase[R] (hyaluronidase for injection) lyophilized, ovine [Package insert]. ... Free with registration - Oncology Nursing Forum - AccessMyLibrary.com

Press Release: ISTA Pharmaceuticals Announces VITRASE(R) …  -  Sep 19, 2005
Evaluation of preservative-free, highly purified hyaluronidase ovine (Vitrase(R)), ... mL vial of Vitrase (hyaluronidase ... for use as a spreading agent. ... Pay-Per-View - PR Newswire - HighBeam Research

Business & Finance; Vitrase maker presents clinical data at medical …  -  Oct 11, 2005
Evaluation of preservative-free, highly purified hyaluronidase ovine ... 6396 - Lack of hypersensitivity reactions to hyaluronidase ovine (Vitrase). ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

Press Release: Halozyme Therapeutics Completes Enrollment of INFUSE …  -  Jan 24, 2006
Hylenex recombinant (hyaluronidase human injection) is indicated for use as an adjuvant agent to increase the absorption and dispersion of other injected ... Pay-Per-View - PR Newswire - HighBeam Research

Drug Delivery; Halozyme initiates Enhanze Technology trial  -  Sep 5, 2006
As a spreading agent, hyaluronidase has traditionally been used to accelerate the delivery of drugs and fluids, including local anesthetics, ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

Halozyme Therapeutics Releases Results of Enhanze Technology …  -  Jan 22, 2007
As a spreading agent, hyaluronidase has traditionally been used to accelerate ... rHuPH20 is the first and only FDA-approved hyaluronidase from recombinant ... Free with registration - M2 Presswire - AccessMyLibrary.com

Developing brain tumors coax assistance from nearby cells  -  Apr 12, 2007
Among other differences, microglia from the mouse model made more of an enzyme called hyaluronidase. Other scientists had previously identified ... News-Medical.net

ISTA Pharmaceuticals Announces VITRASE(R) Spreading Agent and …  -  Sep 19, 2005
6396 -- Lack of hypersensitivity reactions to hyaluronidase ovine (Vitrase(R)) ... 6423 -- Retrobulbar block: the role of Vitrase(R) (hyaluronidase ovine) ... RedOrbit

Baxter Introduces HYLENEX For Use In Ophthalmic Surgery  -  Apr 27, 2007
HYLENEX is the first and only human recombinant hyaluronidase ... "The incorporation of animal-derived hyaluronidase into the anesthetic protocol for ... emaxhealth.com

Halozyme Therapeutics Completes Enrollment of Enhanze Technology …  -  Nov 27, 2006
As a spreading agent, hyaluronidase has traditionally been used to accelerate the delivery of drugs and fluids, including local anesthetics, ... Free with registration - PR Newswire - AccessMyLibrary.com

Halozyme Therapeutics Announces FDA 510(k) Clearance for MediCult's …  -  May 23, 2006
SynVitro Cumulase is a formulation of rHuPH20 (recombinant human PH20 hyaluronidase) prepared in MediCult's proprietary SynVitro media, and is ready to use ... Free with registration - PR Newswire - AccessMyLibrary.com

Brain Tumors Coax Important Support From Nearby Immune System Cells  -  Apr 16, 2007
Among other differences, microglia from the mouse model made more of an enzyme called hyaluronidase. Other scientists had previously identified ... Medical News Today - Medical News Today (press release)

Shutting down microglia  -  Apr 15, 2007
Among other differences, microglia from the mouse model made more of an enzyme called hyaluronidase. Other scientists had previously identified ... News-Medical.net

Harvesting of fertilized eggs  -  Feb 12, 2006
The cumulus cells will need to be removed in a hyaluronidase solution of 300 ... Those that remain should be treated with hyaluronidase, an enzyme found in ... The Rhode Island Green

The FDA's assessment of follow-on protein products: a historical …  -  Mar 1, 2007
Mammalian testicular hyaluronidase. Mammalian testicular hyaluronidase is a natural-source protein derived from bovine or ovine testicles that is indicated ... Nature.com

Halozyme Therapeutics and Reproductive Biology Associates Announce …  -  Jun 22, 2005
Dr. Nagy presented clinical studies comparing Cumulase to a currently used slaughterhouse-derived hyaluronidase extract in the preparation of human oocytes ... $4.95 - PR Newswire - ECNext

Press Release: ISTA Pharmaceuticals Launches Vitrase(R) in the United...  -  Jan 6, 2005
PR Newswire; September 19, 2005 ; 700+ words ... ... hyaluronidase ovine (Vitrase(R)), 200 USP units/mL, as an adjuvant ... the FDA approved Vitrase(R) in a ... Pay-Per-View - PR Newswire - HighBeam Research

Press Release: Halozyme Therapeutics Announces Launch of Cumulase …  -  Jun 20, 2005
The active pharmaceutical ingredient in Cumulase is the first and only recombinant human hyaluronidase approved in the United States and in the European ... Pay-Per-View - PR Newswire - HighBeam Research

Press Release: Halozyme Therapeutics to Present Preclinical, Toxicolog...  -  Mar 28, 2006
Pre-clinical data on the pharmacology and toxicology of rHuPH20, a recombinant human hyaluronidase, with mitomycin will be presented along with clinical ... Pay-Per-View - PR Newswire - HighBeam Research

Drug Development; INFUSE-LR study data indicate Hylenex accelerates …  -  Mar 14, 2006
Hylenex is a liquid injectable formulation that includes the active pharmaceutical ingredient, recombinant human hyaluronidase (rHuPH20), which is approved ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

Press Release: Halozyme Therapeutics Initiates Clinical Trial of …  -  Feb 2, 2006
Hylenex is a liquid injectable formulation that includes the active pharmaceutical ingredient, recombinant human hyaluronidase (rHuPH20). ... Pay-Per-View - PR Newswire - HighBeam Research

Assisted Reproduction; Significantly increased fertilization rates …  -  Jul 19, 2005
Dr. Nagy presented clinical studies comparing cumulase to a currently used slaughterhouse-derived hyaluronidase extract in the preparation of human oocytes ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

… Clinical Safety and Tolerability Data for rHuPH20 Hyaluronidase  -  Jun 21, 2005
Hyaluronidase that is injected in the skin or in the muscle can temporarily digest the HA gel to enhance the penetration and diffusion of other injected ... Pay-Per-View - PR Newswire - HighBeam Research

Enzyme accelerates subcutaneous infusion rate.(Clinical Rounds) | …  -  May 1, 2007
...find Internal Medicine News articles. SALT LAKE CITY -- Recombinant human hyaluronidase makes it possible to safely hydrate patients subcutaneously... Pay-Per-View - Internal Medicine News - HighBeam Research

Press Release: Halozyme Therapeutics and Baxter Healthcare …  -  Dec 5, 2005
Approval Marks the First Recombinant Human Hyaluronidase Approved for Use as ... Hylenex recombinant (hyaluronidase human injection) is indicated for use as ... Pay-Per-View - PR Newswire - HighBeam Research

Press Release: Halozyme Therapeutics Announces FDA 510(k) …  -  May 23, 2006
SynVitro Cumulase is a formulation of rHuPH20 (recombinant human PH20 hyaluronidase) prepared in MediCult's proprietary SynVitro media, and is ready to use ... Pay-Per-View - PR Newswire - HighBeam Research

Brand Names/Synonyms:
Hyaluronidase is also known by the following brand names and/or synonymsHyaluronidase 1 precursor;Hyal-1;Hyaluronidase PH-20;Sperm surface protein PH-20;Sperm adhesion molecule 1; Vitrase (Ista Pharma)

Drug Category:
Hyaluronidase is categorized under the following by the FDA: Permeabilizing Agents; Anesthetic Adjuvants; enzymes (44:00.00)

Dosage Forms:
LIQUID

Absorption:
Not Available

Interactions:
Not Available



Chemical IUPAC Name:
Sheep hyaluronidase





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