Idarubicin

This page contains recent news articles, when available, and an overview of Idarubicin but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Idarubicin
(when available)

Pharmacology and use:
Idarubicin is an antineoplastic in the anthracycline class. General properties of drugs in this class include: interaction with DNA in a variety of different ways including intercalation (squeezing between the base pairs), DNA strand breakage and inhibition with the enzyme topoisomerase II. Most of these compounds have been isolated from natural sources and antibiotics. However, they lack the specificity of the antimicrobial antibiotics and thus produce significant toxicity. The anthracyclines are among the most important antitumor drugs available. Doxorubicin is widely used for the treatment of several solid tumors while daunorubicin and idarubicin are used exclusively for the treatment of leukemia. Idarubicin may also inhibit polymerase activity, affect regulation of gene expression, and produce free radical damage to DNA. Idarubicin possesses an antitumor effect against a wide spectrum of tumors, either grafted or spontaneous. The anthracyclines are cell cycle-nonspecific. For the treatment of acute myeloid leukemia (AML) in adults. This includes French-American-British (FAB) classifications M1 through M7.

Mechanism Of Action:
Idarubicin has antimitotic and cytotoxic activity through a number of proposed mechanisms of action: Idarubicin forms complexes with DNA by intercalation between base pairs, and it inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the ligation-religation reaction that topoisomerase II catalyzes.

News Articles on Idarubicin

Infusion Nurses Society References Totect(R) (Dexrazoxane For Injection) as ...  -  ‎Dec 14, 2009‎
...(1) Anthracyclines are a group of chemotherapy medications including daunorubicin, doxorubicin, idarubicin and epirubicin that have been used in the ... PR Newswire (press release)

What's New in Acute Myeloid Leukemia  -  ‎Dec 11, 2009‎
A systematic collaborative overview of randomized trials comparing idarubicin with daunorubicin (or other anthracyclines) as induction therapy for acute ... American Journal of Hemotology and Oncology

Pharmazeutische Wirkstoffe zur Krebsbekämpfung  -  ‎Dec 17, 2009‎
Mit der Biosynthese von Epi- und Idarubicin - die als Anti-Tumor-Wirkstoffe in der Krebstherapie genutzt werden - hat der Pharmabereich sein ... innovations report

THIRD QUARTER REPORT 2009  -  ‎Oct 22, 2009‎
The Phase II study of elacytarabine in combination with idarubicin in AML patients who have failed their first course of treatment has received ... Therapeutics Daily (press release) (registration)

Teva, Pfizer Reach Patent Deal  -  Nov 21, 2006
Idarubicin is sold under the brand name Idamycin by Pfizer. The company markets azithromycin as Zithromax. Teva will continue to market its generic versions ... TheStreet.com - TheStreet.com (subscription)

Intensive consolidation versus oral maintenance therapy in patients...  -  Jan 26, 2006
The treatment schedule was as follows: after a first up-front randomization for the addition of ATRA to induction therapy with two cycles of ICE (idarubicin ... Nature.com

AML patients with Down syndrome have a high cure rate with AML-BFM …  -  May 26, 2005
4 days and idarubicin 7 mg/m 2 on days 3 and 5; intrathecal cytarabine on days 0 and ... AML-BFM-98 for DS patients: AIE – as above, but idarubicin 8 mg/m 2 ... Nature.com

CuraGen And TopoTarget Initiate Phase I/II Clinical Trial Of Belinosta...  -  Aug 29, 2007
Patients will receive standard doses of idarubicin in combination with either belinostat administered intravenously once daily for five days, ... Medical News Today - Medical News Today (press release)

Breast Cancer; Idarubicin displayed cytotoxic effect on breast cancer...  -  Mar 7, 2006
According to recent research published in the Journal of Chemotherapy, "Despite extensive preclinical evaluation in several experimental models, ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

… Agreement with Pfizer Regarding Idarubicin, Azithromycin, and...  -  Nov 22, 2006
Teva Announces Agreement with Pfizer Regarding Idarubicin, Azithromycin, and Epirubicin. from M2 Presswire. Highbeam Research – FREE Trial. Pay-Per-View - M2 Presswire - HighBeam Research

Why It Is Used  -  Nov 26, 2008
Idarubicin is one of the drugs used in chemotherapy to treat acute ... Idarubicin works well as part of the chemotherapy for some people with AML. ... WebMD

Twenty years of Polish experience with three consecutive protocols...  -  Sep 29, 2005
A new treatment protocol employing idarubicin in place of daunorubicin was ... As shown in Table 3, idarubicin used in the induction phase produced more ... Nature.com

טבע חתמה ×¢×? חברת התרופות פייזר על הסכ×? פיצוי  -  Nov 21, 2006
...והתרופות לטיפול בסרטן idarubicin ו-epirubicin. ... לגבי מכירות המוצר הגנרי של idarubicin. ... ynet ידיעות ×?חרונות - ynet ידיעות ×?חרונות

Molecular and cytogenetic characterization of a new case of t(5;17)(q3...  -  Jan 27, 2005
The patient received idarubicin (12 mg/m 2 on alternative days) and ATRA (45 ... After the first consolidation cycle with idarubicin (5 mg/m 2 /die for 4 ... Nature.com

TopoTarget og CuraGen indleder fase I/II undersøgelse med belinostat  -  Aug 28, 2007
Patienterne vil få standarddoser idarubicin i kombination med enten belinostat indgivet intravenøst én gang dagligt i fem dage eller kontinuerlig infusion ... Netposten - Netposten (abonnement)

טבע: ×?ישור FDA לייצור תרופה לטיפול בכ×?בי ר×?ש  -  Nov 29, 2006
...בנוגע ל-3 תרופות - ×”×?נטיביוטיקה ×?זיתרומיצין, והתרופות לטיפול בסרטן idarubicin ו-epirubicin. ... ynet ידיעות ×?חרונות - ynet ידיעות ×?חרונות

כלכלה nrg - ...בורסה: המעו"×£ בשי×? חדש; ×?סי×? השקעות ×–×™× ×§×”  -  Nov 22, 2006
...idarubicin ו-epirubicin (תרופות לטיפול בסרטן) ומכירות ... לגבי מכירות sicor של המוצר הגנרי idarubicin ... NRG מעריב

High-dose cytarabine and mitoxantrone in consolidation therapy for...  -  Apr 21, 2005
AIDA (all-trans retinoic acid+idarubicin) in newly diagnosed acute promyelocytic leukemia: a Gruppo Italiano Malattie Ematologiche Maligne dell'Adulto ... Nature.com

Targeting the most critical cells: approaching leukemia therapy as a ...  -  Feb 8, 2005
3 The study is testing use of the anthracycline idarubicin and the proteasome inhibitor ... The trial design specifies administration of idarubicin first, ... Nature.com

Press Release: CuraGen and TopoTarget Initiate Phase I/II Clinical...  -  Aug 28, 2007
Patients will receive standard doses of idarubicin in combination with either belinostat administered intravenously once daily for five days, ... Pay-Per-View - PR Newswire - HighBeam Research

Risk factors for invasive aspergillosis in neutropenic patients with ...  -  Feb 24, 2005
Cycle 1 consisted of idarubicin (12 mg/m 2 iv on days 1, 3, and 5), ... Patients with de novo ALL have received a first cycle with idarubicin (9 mg/m 2 iv ... Nature.com

Woman died after overdose of chemotherapy drug, inquest told  -  Nov 13, 2008
..."I put in the dose of Idarubicin incorrectly," James said. "The records showed that she had been given four times the required dose. ... guardian.co.uk

Chronic idiopathic myelofibrosis expressing a novel type of TEL...  -  Nov 23, 2006
Despite the intensive chemotherapy with cytarabine and idarubicin, leukaemic cells reappeared in the peripheral blood. The patient succumbed to multiple ... Nature.com

Two new cases of acute promyelocytic leukemia following mitoxantrone ...  -  Oct 19, 2006
The patient was treated with all-trans retinoic acid (ATRA) 45 mg/m 2 for 30 days and intravenous Idarubicin at a dosage of 12 mg/m 2 on days 2, 4, ... Nature.com

Press Release: Aegera Therapeutics' phase 1/2 clinical trial results ...  -  Nov 25, 2008
The presentation is entitled "Phase I/II Trial of the XIAP Antisense Oligonucleotide (AEG35156) in Combination with Idarubicin and Cytarabine in Patients ... Pay-Per-View - PR Newswire - HighBeam Research

TopoTarget's inhibitor shows positive results in Phase I/II study in...  -  Dec 8, 2008
Both regimens are examined in a dose escalation form in a combination with idarubicin with which belinostat showed a high degree of synergy in pre-clinical ... $9.94 - M2 Europharma - Alacra Store

Thyroid late effects after treatment of childhood sarcoma  -  Jul 26, 2007
In addition, TSH levels were elevated in patients treated with idarubicin (P = 0.037) and trofosfamide (P = 0.008); however, the number of patients who ... Nature.com

Occurrence of thrombotic events in acute promyelocytic leukemia …  -  Aug 24, 2006
We analyzed 124 APL patients treated with the all-trans retinoic acid and idarubicin protocol and compared clinico-biologic characteristics of 11 patients ... Nature.com

L-theanine.(Monograph)  -  Jun 1, 2005
L-theanine increases the activity of doxorubicin, idarubicin, pirarubicin, cisplatin, and irinotecan in tumor cells. (7-10,15) Side Effects and Toxicity ... Free with registration - Alternative Medicine Review - AccessMyLibrary.com

No role for CXCL12–G801A polymorphism in the development of …  -  Sep 6, 2007
Cytarabine 2 g m -2 on days 1–4; Idarubicin 12 mg m -2 in patients ... on days 2–4) while 91 patients (58%) received a '3+7' course (Idarubicin 12 mg m ... Nature.com

Genomic and molecular switching in relapsed acute promyelocytic …  -  Feb 7, 2008
Idarubicin and trans-retinoic acid were started following the All-trans retinoic acid+Idarubicin (AIDA) protocol of the Gruppo Italiano Malattie ... Nature.com

Large interindividual differences in cellular sensitivity to calicheam...  -  Jun 19, 2008
In addition to calicheamicin, a subset of samples was also tested for in vitro sensitivity to etoposide, cytarabine, daunorubicin, idarubicin, mitoxantrone, ... Nature.com

Gemtuzumab therapy for isolated extramedullary AML relapse following ...  -  Feb 27, 2007
Management Primary leukemia treatment with idarubicin, cytarabine, ... He received idarubicin (5 mg/m 2 daily for 4 days) or daunorubicin (20 mg/m 2 daily) ... Nature.com

Teva settles with Pfizer: All patent disputes between the companies...  -  Nov 21, 2006
Idarubicin is a cancer treatment and azithromycin is an antibiotic. The agreement resolves all outstanding patent litigation filed by Pfizer subsidiary ... Pay-Per-View - Globes - HighBeam Research

Optimizing therapy with methylation inhibitors in myelodysplastic …  -  Aug 17, 2005
Thirty patients received amsacrine, 120 mg/m 2 as a 1-h infusion on days 6 and 7, as adjunctive therapy, and the remaining 33 patients received idarubicin ... Nature.com

Absolute lymphocyte count recovery after induction chemotherapy …  -  Nov 10, 2005
In all, 90 patients underwent IC with Idarubicin (12 mg/m 2 /day) on days 1, 2 ,3 and continuous infusion cytarabine (100 mg/m 2 /day) on days 1–7; ... Nature.com

Drug Stocks End Short Week Lower  -  Nov 27, 2006
The companies agreed to grant each other full releases for the drugs; Teva will continue to market generic versions of idarubicin and azithromycin in ... Forbes

Common 4q24 deletion in four cases of hematopoietic malignancy: early...  -  May 26, 2005
Despite consolidation cures with idarubicin and cytarabine, followed by high-dose cytarabine, peripheral blast cells persisted. The patient died from sepsis ... Nature.com

Aegera Therapeutics' phase 1/2 clinical trial results selected for...  -  Nov 25, 2008
The presentation is entitled "Phase I/II Trial of the XIAP Antisense Oligonucleotide (AEG35156) in Combination with Idarubicin and Cytarabine in Patients ... Genetic Engineering News - Genetic Engineering News (press release)

Efficacy of single dose pegfilgrastim in enhancing the mobilization...  -  Jul 31, 2006
...dexamethasone 20 mg intravenous (iv) 4 days) or idarubicin, platinum, asacytin, dexamethasone (IPAD) (idarubicin 12 mg/m 2 iv day 1, cisplatin 50 mg/m 2 ... Nature.com

Vion Pharmaceuticals Enters Into Agreement With HOVON to Conduct a …  -  Aug 19, 2008
Part B is then designed to evaluate the clinical efficacy of the laromustine combination versus two cycles of cytarabine and idarubicin without laromustine ... Lifescience-online

Anti-leukaemic role of acute GvHD after unrelated haematopoietic stem...  -  Oct 8, 2007
Induction chemotherapy with Idarubicin plus N4-behenoyl-1-bD-arabinofuranosylcytosine in acute myelogenous leukemia: a newly designed induction regimen—a ... Nature.com

The size of duplication does not add to the prognostic significance...  -  Aug 31, 2006
Cytarabine 2 g/m 2 on days 1–4; Idarubicin 12 mg/m 2 on days 1–3 in patients younger than 65 years and 8 mg/m 2 on days 1–3 in patients older than 65 ... Nature.com

Life Science News Briefs Vol. 8 no.32 — December 5, 2008  -  Dec 5, 2008
The presentation is entitled "Phase I/II Trial of the XIAP Antisense Oligonucleotide (AEG35156) in Combination with Idarubicin and Cytarabine in Patients ... ic.gc.ca

Belinostat enters Ph I/II trial.  -  Sep 3, 2007
...in combination with the anthracycline idarubicin for the treatment of acute ... intravenous therapy with a combination of belinostat and idarubicin. ... $9.94 - Pharma Marketletter - Alacra Store

The sensitivity of human cells expressing RUNX1-RUNX1T1 to …  -  Aug 17, 2006
...to a number of drugs commonly used to treat AML (Daunorubicin, Cytarabine, Fludarabine, Idarubicin or Etoposide) in comparison with matched controls. ... Nature.com

A novel translocation t(3;21)(p21;q22) in acute myelogenous leukemia ...  -  Jun 22, 2006
He received induction therapy with cytarabine hydrochloride (ara-C) and idarubicin on a 7+3 regimen (ara-C and idarubicin), and achieved a complete ... Nature.com

A phase I study of tipifarnib combined with conventional induction...  -  Dec 18, 2008
14 A Phase II study using this agent in combination with idarubicin and high-dose cytarabine in previously untreated AML yielded response rates and ... Nature.com

Article: FDA approves vaccine to prevent gastroenteritis caused by …  -  May 1, 2008
APP's Idarubicin is AP-rated, bar-coded and latex-free. According to IMS data, 2008 sales of this ... Idarubicin belongs to a class of drugs called ... ... Pay-Per-View - Pharmaceutical Processing - HighBeam Research

Aegera to present study Phase I/II study findings with AEG35156 at...  -  Nov 26, 2008
The oral presentation is entitled "Phase I/II Trial of the XIAP Antisense Oligonucleotide (AEG35156) in Combination with Idarubicin and Cytarabine in ... $9.94 - M2 Europharma - Alacra Store

The authors respond.  -  Mar 1, 2007
Idarubicin - Mechlorethamine - Mitomycin - Mitoxantrone - Oxaliplatin - Paclitaxel Saline exerts a dilutional effect. ... Free with registration - Oncology Nursing Forum - AccessMyLibrary.com

Gemtuzumab ozogamicin (Mylotarg ® ) as single-agent treatment for...  -  Aug 4, 2005
The authors compared these results with historical controls of similar patients treated with idarubicin and cytosine arabinoside (IA), and concluded for the ... Nature.com

Epirubicin (Systemic ).  -  Feb 1, 2006
Tell your doctor if you have ever had any unusual or allergic reaction to daunorubicin, doxorubicin, epirubicin, idarubicin, or mitoxantrone. ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Epirubicin (Systemic ).(Drug overview)  -  May 1, 2006
Tell your doctor if you have ever had any unusual or allergic reaction to daunorubicin, doxorubicin, epirubicin, idarubicin, or mitoxantrone. ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Merck and Vertex Announce Phase I Results for Investigational Aurora ...  -  Dec 11, 2006
..."The results of preclinical data support clinical evaluation of MK-0457 in combination with idarubicin and Ara-C in patients with AML and in combination ... $4.95 - Business Wire - ECNext

Loislaw Federal District Court Opinions - PHARMACIA & UPJOHN v. …  -  Aug 17, 2006
...claims: A physiologically acceptable solution of anthracycline glycoside selected from the group consisting of idarubicin hydrochloride, ... Pay-Per-View - Loislaw Federal District Court Opinions - Loislaw

Press Release: CuraGen and TopoTarget Announce Expansion of …  -  Dec 14, 2006
Phase I/II clinical trial evaluating belinostat (PXD101), a histone deacetylase ... intravenous treatment with a combination of belinostat and idarubicin. ... Pay-Per-View - PR Newswire - HighBeam Research

Press Release: Pfizer Announces Settlement With Teva on Patents …  -  Nov 21, 2006
Under the agreement Sicor will be able to continue to market idarubicin, which it launched prior to patent expiry in September 2002, and Teva can continue ... Pay-Per-View - PR Newswire - HighBeam Research

Drug Development; Third clinical trial initiated for AEG35156 for...  -  Mar 7, 2006
This phase I trial is an open-label study of AEG35156 administered in combination with ara-C and idarubicin in patients with refractory or relapsed acute ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

Aegera initiates third clinical trial for AEG35156 - A targeted...  -  Feb 15, 2006
This Phase I trial is an open-label study of AEG35156 administered in combination with ara-C and idarubicin in patients with refractory or relapsed acute ... $4.95 - PR Newswire - ECNext

Cell Biology; Recent findings from Finland, Turkey and the United...  -  May 16, 2006
Oyan and colleagues published their study in Biology of Blood and Marrow Transplantation (Ifosfamide, idarubicin, and etoposide in relapsed/refractory ... Pay-Per-View - Medical Devices & Surgical Technology... - Factiva, from Dow Jones

Multiple myeloma patients receiving pre-emptive donor lymphocyte …  -  Jun 11, 2007
...(total dose 120 mg/kg) and TBI (9 Gy) in 23 patients, and in 5 cases conditioning was intensified by the addition of idarubicin (total dose 42 mg/m 2 ). ... Nature.com

Treatment of relapsed acute myeloid leukemia with MLL/AF6 fusion...  -  Nov 8, 2007
...at which time we applied aggressive reinduction chemotherapy (idarubicin+Ara-C+etoposide). However, the chemotherapy did not have a sufficient effect. ... Nature.com

A 'good death' for tumor immunology  -  Jan 1, 2007
These agents, which include doxorubicin, idarubicin and mitoxantrone, operate by activating caspases and have been typically associated with profound ... Nature.com

Common genetic variants in the interleukin-6 and chitotriosidase...  -  Aug 18, 2005
All patients received induction therapy with either daunorubicin or idarubicin in combination with cytarabine and etoposide. After induction, patients were ... Nature.com

Pfizer и Teva урегулировали патентные Ñ?поры  -  Nov 22, 2006
ИзраильÑ?каÑ? компаниÑ? обвинÑ?лаÑ?ÑŒ в нарушении патентных прав на idarubicin и azithromycin. По уÑ?ловиÑ?м Ñ?оглашениÑ?, Teva выплатит американÑ?кой компании 70 млн ... ФармацевтичеÑ?кий веÑ?тник

×?רה"ב סגרה ×?ת יו×? המסחר בעליות; ט×?ו×?ר ירדה 4.25%  -  Nov 22, 2006
...idarubicin (תרופה לטיפול בסרטן) ו-epirubicin (תרופה ... לגבי מכירות Sicor של המוצר הגנרי idarubicin ... Bizportal

Treatment of AML and MDS relapsing after reduced-intensity conditionin...  -  Jul 5, 2007
Preparative regimens consisted of either a non-ablative regimen of fludarabine, cytarabine and idarubicin (FAI), or with a reduced intensity regimen of ... Nature.com

Functional MR imaging of tumor angiogenesis predicts outcome of …  -  Dec 15, 2005
All patients received dMRI (median of 1 day, range: 0–2 days) before induction chemotherapy of Idarubicin 12 mg/m 2 per day on days 1–3 and cytosine ... Nature.com

Eosinophilic cystitis following cord blood transplantation: a form of...  -  Jul 7, 2008
Initially, the patient was treated with a combination of idarubicin and ara-C as induction chemotherapy, but this regimen was ineffective. ... Nature.com

Having a higher blast percentage in circulation than bone marrow:...  -  Jul 28, 2005
All patients were treated with regimens containing ara-C and/or idarubicin, with or without fludarabine and topotecan. The minor differences in therapy did ... Nature.com

Cancer Health Center  -  Nov 26, 2008
Acute promyelocytic leukemia (APL) drugs include all-trans-retinoic acid (ATRA) and chemotherapy with arsenic trioxide, idarubicin, or daunorubicin. ... WebMD

Expression of Polycomb-group (PcG) protein BMI-1 predicts prognosis...  -  Mar 22, 2007
To facilitate comparison, we graded the standard dose of idarubicin (IDA) or daunorubicin (DNR) and cytosine arabinoside (Ara-C) as treatment intensity-3 ... Nature.com

An unusual cause of acute abdomen following allogeneic transplantation...  -  Mar 3, 2008
The patient received induction chemotherapy with fludarabine, cytarabine, idarubicin and G-CSF. Eight days after the completion of induction chemotherapy, ... Nature.com

Marrow angiogenesis-associated factors as prognostic biomarkers in …  -  Sep 11, 2007
...underwent conventional induction chemotherapy with one of the anthracyclines (doxorubicin or idarubicin) for 3 days and cytosine arabinoside for 7 days. ... Nature.com

Extramedullary relapse of multiple myeloma presenting as hematemesis ...  -  Sep 17, 2005
Initial tumor reduction with four cycles of cyclophosphamide, idarubicin, and dexamethasone chemotherapy 1 was followed by high-dose chemotherapy (melphalan ... Nature.com

Successful matched unrelated BMT for secondary AML which developed …  -  Mar 12, 2007
She underwent induction chemotherapy consisting of idarubicin and cytarabine in August 2004. Her lymphadenopathy completely disappeared after the first ... Nature.com

Interferon- is able to maintain complete molecular remission induced...  -  Apr 3, 2008
Patient 2 was a 34-year-old woman with CML diagnosed in June 1993 and treated with hyrdroxyurea, mini idarubicin citarabine and etoposide (ICE), ... Nature.com

Molecular detection of GNNK- and GNNK+ c-kit isoforms: a new tool for...  -  Jun 7, 2007
Eleven patients received idarubicin, 35 doxorubicin, 12 daunorubicin plus etoposide and 5 mitoxantrone in the induction therapy. ... Nature.com

Acute myelogenous leukemia in Chile PINDA protocols 87 and 92 results  -  Mar 17, 2005
Five patients in PINDA 87 protocol were treated with received Idarubicin 12 mg/m 2 iv on days 3–5 instead of daunorubicin, thanks to a donation of ... Nature.com

Do RARA/PML fusion gene deletions confer resistance to ATRA-based …  -  Sep 28, 2006
The patient achieved hematologic remission after treatment with ATRA and idarubicin. However, a bone marrow biopsy 30 days post-therapy showed dysplastic ... Nature.com

A new type of NPM1 gene mutation in AML leading to a C-terminal …  -  Apr 5, 2007
The patient was treated with idarubicin and cytosine arabinoside (ara-C) as induction therapy followed by two cycles of high doses ara-C as consolidation. ... Nature.com

Outcome of allo-SCT for chronic myelomonocytic leukemia  -  Nov 10, 2008
Intensive chemotherapy with idarubicin, cytarabine, etoposide, and G-CSF priming in patients with advanced myelodysplastic syndrome and high-risk acute ... Nature.com

Alemtuzumab as first-line therapy for B-cell chronic lymphocytic...  -  Oct 19, 2006
...purine analogs (cladribine or fludarabine) alone (n=27) or in combination with idarubicin or cyclophosphamide (n=3), or other combination chemotherapy ... Nature.com

Conditioning with fludarabine alone and allogeneic transplantation as...  -  Nov 20, 2006
Because of the resistant nature of the leukemia, therapy with fludarabine, high-dose cytosine arabinoside and idarubicin was commenced in spite of ... Nature.com

Late first relapses in APL treated with all-trans-retinoic acid- and ...  -  Mar 16, 2006
Induction therapy with idarubicin alone significantly influences event-free survival duration in patients with newly diagnosed hypergranular acute ... Nature.com

Nucleophosmin status may influence the therapeutic decision in de...  -  Jun 22, 2006
All patients were treated by induction chemotherapy combining daunorubicin or idarubicin and aracytin. Patients under 60 years (n=75) with human lymphocyte ... Nature.com

A novel NUP98-PHF23 fusion resulting from a cryptic translocation...  -  Feb 8, 2007
He was newly diagnosed with AML and received induction therapy of idarubicin and ara-C followed by four cycles of high-dose ara-C consolidation. ... Nature.com

Allogeneic stem cell transplantation and donor lymphocyte infusions...  -  Apr 10, 2006
Of these, nine patients received standard AML induction chemotherapy (either idarubicin (n=7) or daunorubicin (n=2) daily over 3 days plus continuous ... Nature.com

The feasibility of using topotecan, vinorelbine, thiotepa and...  -  Feb 28, 2008
6 It has shown efficacy when used in combination with agents like carboplatin, fludarabine, etoposide, idarubicin and cytarabine in various clinical trials. ... Nature.com

Hookworm infection of sigmoid colon masquerading as graft-versus-host...  -  Feb 27, 2006
...previously treated with liposomal all-trans-retinoic acid (ATRA) plus idarubicin, arsenic trioxide (ATO) and oral ATRA underwent an allogeneic SCT from ... Nature.com

A case of therapy-related acute myeloid leukemia associated with...  -  Jan 26, 2006
After induction chemotherapy with idarubicin and N 4 -behenoyl-1--D-arabinofuranosylcytosine, she attained CR. A molecular assessment of the response to the ... Nature.com

Long-term outcome of high-dose melphalan and autologous stem cell …  -  Mar 27, 2006
Before HDM-ASCT, eight patients were treated with cyclic chemotherapy with either vincristine, adriamycin, dexamethasone (VAD) (n=4), idarubicin, ... Nature.com

Pediatric acute myeloid leukemia: international progress and future …  -  Jul 28, 2005
...complicated by the use of different drugs than daunorubicin or doxorubicin, such as idarubicin, mitoxantrone and since recently liposomal daunorubicin. ... Nature.com

יו×? ד': הבורסה שוב שוברת שי×?×™×?; הדולר: 4.321 ש'  -  Nov 22, 2006
...×”×?נטיביוטיקה ×?זיתרומיצין, והתרופות לטיפול בסרטן idarubicin ו-epirubicin בסכו×? של עד 70 מליון. ... ynet ידיעות ×?חרונות - ynet ידיעות ×?חרונות

Role of cytokines in the treatment of acute leukemias: a review  -  Feb 23, 2006
The regimen consisted of two cycles of chemotherapy with Cycle 1 including cytarabine 200 mg/m 2 daily on days 1–7 and idarubicin 12 mg/m 2 on days 6, 7, ... Nature.com

יו×? ×’': המסחר ננעל בעליות; טבע עלתה ב-2.1%  -  Nov 21, 2006
...בנוגע ל-3 תרופות - ×”×?נטיביוטיקה ×?זיתרומיצין, והתרופות לטיפול בסרטן idarubicin ו-epirubicin. ... ynet ידיעות ×?חרונות - ynet ידיעות ×?חרונות

Kidney cancer drug attacks a major type of acute myeloid leukaemia  -  Jan 30, 2008
...for AML is open at MD Anderson that combines sorafenib with the standard of care chemotherapy combination for AML, idarubicin and cytosine arabinoside. ... Science Centric

TopoTarget fokuserer pÃ¥ kræft efter misser  -  Aug 7, 2007
...et fase I/II studier med Belinostat i kombination med Idarubicin til behandling af akut myeloid Leukæmi. Dette studie vil involvere op til 70 patienter. ... Børsen Online

ת"×? חתמה בירידות וסיכמה שבוע שלילי בבורסה  -  Nov 23, 2006
...idarubicin (תרופה לטיפול בסרטן) ו-epirubicin (תרופה לטיפול בסרטן) ומכירות של מוצרי×? גנרי×? ×?לו. ... NRG מעריב

וול סטריט: צ'×§ פוינט בשי×? של 13 חודשי×? - ×–×™× ×§×” בכ-4% בתגובה לשתי  -  Nov 21, 2006
...תרופה כנגד סרטן ששמה ×?יד×?רוביצין (idarubicin), ותרופה נוספת ששמה ×?פירוביצין (epirubicin). ... ×”×?רץ

Antioxidant use during chemo- and radiotherapy for cancer.  -  Feb 1, 2005
Blasiak and colleagues reported on an in vitro model in which vitamins C and E were used as a means of protecting normal cells during idarubicin therapy. ... Free with registration - Alternative Medicine Alert - AccessMyLibrary.com

Kidney Cancer Drug Attacks A Major Type Of Acute Myeloid Leukemia  -  Feb 1, 2008
...for AML is open at MD Anderson that combines sorafenib with the standard of care chemotherapy combination for AML, idarubicin and cytosine arabinoside. ... sciencedaily.com

Novantrone Linked to Cardiotoxicity and AML in MS and Cancer Patients  -  May 25, 2005
...to be related to a cumulative mitoxantrone dose of 72 mg/m 2 , and the patient has been in remission following treatment with idarubicin and ara-C. ... Medscape

Brand Names/Synonyms:
Idarubicin is also known by the following brand names and/or synonymsIDARUBICIN; Idamycin; Idamycin Pfs; Idarubicin; Idarubicin Aglycone; Idarubicin Hcl; Idarubicin Hcl Pfs; Idarubicin Hydrochloride; Idarubicina [Inn-Spanish]; Idarubicine [Inn-French]; Idarubicinum [Inn-Latin]

Drug Category:
Idarubicin is categorized under the following by the FDA: Antibiotics; Antineoplastic Agents; ATC:L01DB06

Dosage Forms:
POWDER FOR SOLUTION

Absorption:
Not Available

Interactions:
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Chemical IUPAC Name:
9-acetyl-7-(4-amino-5-hydroxy-6-methyl-tetrahydropyran-2-yl)oxy-6,9,11-trihydroxy-7,8,9,10-tetrahydrotetracene-5,12-dione





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