Idoxuridine

This page contains recent news articles, when available, and an overview of Idoxuridine but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Idoxuridine
(when available)

Pharmacology and use:
In chemical structure idoxuridine closely approximates the configuration of thymidine, one of the four building blocks of DNA (the genetic material of the Herpes virus). As a result, idoxuridine is able to replace thymidine in the enzymatic step of viral replication or "growth". The consequent production of faulty DNA results in a pseudostructure which cannot infect or destroy tissue. In short, by pre-empting a vital building block in the genetic material of the Herpes simplex virus, Herplex-D topical solution destroys the infective and destructive capacity of the viral material. The virus infected cell may only be attacked during the period of active synthesis of DNA. This occurs early in the development of the Herpes simplex lesion, but at different times in different cells. Therefore, ideally, the affected area should remain saturated with the antiviral agent. For use in keratoconjunctivitis and keratitis caused by herpes simplex virus

Mechanism Of Action:
Idoxuridine acts as an antiviral agent against DNA viruses by inhibiting thymidilate phosphorylase and viral DNA polymerases. The effect of Idoxuridine results in the inability of the virus to reproduce or to infect/destroy tissue.

News Articles on Idoxuridine

Idoxuridine (Ophthalmic).  -  Feb 1, 2006
Idoxuridine (eye-dox-YOOR-i-deen) belongs to the family of medicines called antivirals. Idoxuridine is used to treat virus infections of the eye. ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

How to take Idoxuridine Ophthalmic from Consumer Reports Health.  -  Jan 10, 2005
Idoxuridine ophthalmic is no longer available in the United States. If you are currently using ... Full Alert. tell your doctor and pharmacist if you are ... consumerreports.org

Learn about Idoxuridine Ophthalmic from Consumer Reports Health.  -  Jan 10, 2005
Idoxuridine ophthalmic is no longer available in the United States. If you are currently using ... Full Alert. Idoxuridine slows the growth of viruses that ... consumerreports.org

Taking Idoxuridine Ophthalmic from Consumer Reports Health.  -  Jan 10, 2005
Idoxuridine ophthalmic is no longer available in the United States. If you are currently using ... Full Alert. Idoxuridine may cause side effects. ... consumerreports.org

Illinois Administrative Code - 77 Ill. Adm. Code 790.5260 IDOXURIDINE...  -  Aug 10, 2005
77 Ill. Adm. Code 790.5260 IDOXURIDINE (Repealed) Repealed. (Source: Repealed at 17 Ill. Reg. 15916, effective September 20, 1993) ... Pay-Per-View - Illinois Administrative Code - Loislaw

Eyecare Partners Ltd acquires UN Optometry Practices(4) (pending) - …  -  Apr 14, 2008
Miscellaneous # Ophthalmology and Optometry ## Respiratory and Pulmonary System…idoxuridine) Disease Hub Ophthalmology and Optometry Description Dendrid ... Pay-Per-View - deals - Alacra Store

Cat's herpes needs lifelong care  -  Apr 7, 2007
Idoxuridine .5 percent is a topical antiviral ointment used 4-6 times a day. It is to be discontinued when the corneal ulcer is healed. ... $2.95 - Detroit News - NewsBank

Cat's eye infection hard to treat  -  Mar 1, 2008
Cats with recurrent herpes viral infections can be treated with interferon-a, idoxuridine 0.5 percent ointment four to six times a day until the ulcer is ... $2.95 - Detroit News - NewsBank

Bottom line: Talk to doctor about shingles shot  -  Dec 18, 2007
There's evidence that DMSO (containing idoxuridine) applied to the skin might improve symptoms of shingles and neuropathic pain. Again, though, there might ... $2.95 - Lexington Herald Leader - NewsBank

SLIPUPS ON STAPH  -  Feb 10, 2007
The vidarabine and idoxuridine recommended “to shorten the duration of rash� are topical preparations for the eye. For patient 2, Dr. Meka cites extremely ... Cortlandt Forum

Liver Cysts, Myasthenia Gravis and Orf  -  Sep 18, 2005
Topical idoxuridine has been used with varying results. Lesions have also responded to cryotherapy. QI was recently consulted by a young girl who may have ... RedOrbit

QUESTION & ANSWER FROM THE PHARMACY: Shingles vaccine is …  -  Dec 10, 2007
There's evidence that DMSO (containing idoxuridine) applied to the skin may improve symptoms of shingles and neuropathic pain. Again, though, there may be ... $2.95 - Press of Atlantic City, The - NewsBank

Pakistan News Service - PakTribune  -  Oct 9, 2005
...or small blisters on the mouth that burst and crust over, treatments may include idoxuridine paint and acyclovir, which is an antiviral drug. ... PakTribune.com

Thuốc mỡ tetraxyclin có chữa khá»?i mụn rá»™p?  -  May 9, 2008
Ä?ể có thể khá»?i bệnh, bạn phải bôi các loại thuốc mỡ, cream hoặc gel có chứa các chất kháng virut như acyclovir, amantadine, idoxuridine, trifluridine, ... Tin nhanh

Clinical: Liver cysts, myasthenia gravis and orf.(treatments and...  -  Sep 2, 2005
Topical idoxuridine has been used with varying results. Lesions have also responded to cryotherapy. Dr Peter Wilson, consultant microbiologist, ... Free with registration - GP - AccessMyLibrary.com

Wisconsin Administrative Code - RL 10.01 Definitions.  -  Jul 16, 2005
Idoxuridine. c. Trifluridine. d. Vidarabine. 4. Acyclovir, an oral antiviral agent. (i) Anti-inflammatory agents. 1. Oral non-steroidal anti-inflammatory ... Pay-Per-View - Wisconsin Administrative Code - Loislaw

Georgia Code - 16-13-71. (a) A "dangerous drug" means any drug other ...  -  Aug 4, 2005
...(464.3) Idoxuridine; (464.5) Idursulfase; (464.6) Ifosfamide; (464.7) Iloprost; (464.8) Imatinib; (465) Imiglucerase; (465.1) Imipenem/cilastatin; ... Pay-Per-View - Georgia Code - Loislaw

Brand Names/Synonyms:
Idoxuridine is also known by the following brand names and/or synonyms5IUDR; 5idu; Allergan 201; Allergan 211; Antizona; CCRIS 2827; Dendrid; Emanil; Heratil; Herpe-Gel; Herpes-Gel; Herpesil; Herpid; Herpidu; Herplex; Herplex Liquifilm; ID2; IDU; IDUR; IUDR; Idexur; Idossuridina [Dcit]; Idoxene; Idoxuridin; Idoxuridina [Inn-Spanish]; Idoxuridine; Idoxuridine [Usan:Ban:Inn:Jan]; Idoxuridinum [Inn-Latin]; Idu Oculos; Iducher; Idulea; Iduridin; Iduviran; Iododeoxyridine; Iodoxuridine; Joddeoxiuridin; Kerecid; NSC 39661; Ophthalmadine; SK&F 14287; Spectanefran; Stoxil; Synmiol; Virudox

Drug Category:
Idoxuridine is categorized under the following by the FDA: Antivirals; Antivirals; Nucleic Acid Synthesis Inhibitors; ATC:D06BB01; ATC:J05AB02; ATC:S01AD01

Dosage Forms:
Opthalmic drops; Ophthalmic ointment

Absorption:
Systemic absorption is unlikely following ocular administration even when nasolacrimal secretions are swallowed, since vidarabine is rapidly deaminated in the gastrointestinal tract

Interactions:
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Chemical IUPAC Name:
1-[4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-iodo-1H-pyrimidine-2,4-dionein





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