Indinavir Sulfate

This page contains recent news articles, when available, and an overview of Indinavir Sulfate but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Indinavir Sulfate
(when available)

Pharmacology and use:
Indinavir is a protease inhibitor with activity against Human Immunodeficiency Virus Type 1 (HIV-1). Protease inhibitors block the part of HIV called protease. HIV-1 protease is an enzyme required for the proteolytic cleavage of the viral polyprotein precursors into the individual functional proteins found in infectious HIV-1. Indinavir binds to the protease active site and inhibits the activity of the enzyme. This inhibition prevents cleavage of the viral polyproteins resulting in the formation of immature non-infectious viral particles. Protease inhibitors are almost always used in combination with at least two other anti-HIV drugs. For the treatment of HIV infection

Mechanism Of Action:
Indinavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles.

News Articles on Indinavir

Dietary Supplements May Increase Longevity Of HIV Patients  -  ‎Nov 8, 2009‎
Specifically the use of St. John's Wort with Crixivan (indinavir sulfate) reduced the effectiveness of this medication. Other protease inhibitors are ... The AIDS Beacon (blog)

PSU to make HIV medicines indinavir sulfate 400, zidovudine 300, …  -  Aug 31, 2006
Pune, August 30: THE long-awaited revival of Hindustan Antibiotics Ltd (HA) may prove to be a damp squib on the operational front for the first PSU ... Expressindia.com

Reyataz Oral : Uses, Side Effects, Interactions, Pictures, Warnings &...  -  Sep 30, 2008
Crixivan (indinavir sulfate) US prescribing information. Merck & Co., Inc. December, 2008. 7.Norvir (ritonavir) US prescribing information. ... WebMD

Ritonavir Oral : Uses, Side Effects, Interactions, Pictures, Warnings...  -  Sep 30, 2008
Crixivan (indinavir sulfate) US prescribing information. Merck & Co., Inc. December, 2008. 3.Viracept (nelfinavir mesylate) US prescribing information. ... WebMD

Merck to Discount Drugs for Uninsured; Prices to Compare to Canadian ...  -  Apr 20, 2005
Indinavir sulfate ... is available. Both Merck and Roche decided that ... will get their drugs. Merck mailed letters Friday ... 000 doctors in the United ... Pay-Per-View - Washington Post - HighBeam Research

Merck Sharp and Dohme (MSD) Again Reduces Price of STOCRIN ( …  -  Mar 16, 2006
...were being treated with antiretroviral regimens containing either of MSD's two current HIV/AIDS medicines, STOCRIN and CRIXIVAN (indinavir sulfate). ... AllAfrica.com

Ritonavir Oral : Uses, Side Effects, Interactions, Pictures, Warnings...  -  Oct 24, 2006
Crixivan (indinavir sulfate) US prescribing information. Merck & Co., Inc. December, 2008. 5.Kaletra (lopinavir/ritonavir tablets) US prescribing ... WebMD

Ritonavir Oral : Uses, Side Effects, Interactions, Pictures, Warnings...  -  Sep 30, 2008
Crixivan (indinavir sulfate) US prescribing information. Merck & Co., Inc. December, 2008. 2.Viracept (nelfinavir mesylate) US prescribing information. ... WebMD

Vaccination and Enrollment Are Discontinued in Phase II Trials of...  -  Sep 21, 2007
In the 1990s, Merck scientists discovered the protease inhibitor, CRIXIVAN([R]) (indinavir sulfate), and the non-nucleoside reverse transcriptase inhibitor, ... Free with registration - Business Wire - AccessMyLibrary.com

Broadway Actress/HIV Advocate, Sheryl Lee Ralph, Unveils Winning …  -  Apr 16, 2007
Propulsid(R) (cisapride), Camptosar(R) (irinotecan hydrochloride), Crixivan(R) (indinavir sulfate), Mevacor(R) (lovastatin), Zocor(R) (simvastatin), ... Free with registration - PR Newswire - AccessMyLibrary.com

Federal Register 2007 - 72 FR 30386 Draft Guidances for Industry …  -  May 31, 2007
Pseudoephedrine HCl Indinavir Sulfate Irbesartan Isosorbide Mononitrate Isradipine (multiple dosage forms) Itraconazole L Lamivudine Lamivudine; ... Pay-Per-View - Federal Register 2007 - Loislaw

Pfizer fined in solvent release case  -  Jan 20, 2005
...in a series of reactions in the synthesis of the human immunodeficiency virus (HIV) protease inhibitor Crixivan (indinavir sulfate), sold by Merck & Co. In-PharmaTechnologist.com

Merck Will Help Expand Access to HIV/AIDS Treatment In Least …  -  Feb 15, 2007
The prices of other formulations of STOCRIN and Merck's other HIV/AIDS medicine, CRIXIVAN (indinavir sulfate), remain unchanged. ... ChinaCSR.com

Merck & Co cuts HIV AIDS drug prices 22%.(Merck and Company Inc …  -  Mar 20, 2006
...countries receiving treatment with anti-retroviral regimens containing either Stocrin, or Merck's other HIV/AIDS product Crixivan (indinavir sulfate). ... Free with registration - Pharma Marketletter - AccessMyLibrary.com

Merck Lowers Price of HIV/AIDS Medication STOCRIN in Poor Countries  -  Mar 7, 2006
...were being treated with antiretroviral regimens containing either of Merck's two current HIV/AIDS medicines, STOCRIN and CRIXIVAN (indinavir sulfate). ... Newsinferno.com

Article: COX-2 inhibitors.(Letters)(Letter to the Editor) - Family...  -  Feb 15, 2005
...announced today that it has discontinued the evaluation of twice- daily dosing regimens of its HIV protease inhibitor, Crixivan(R) (indinavir sulfate), ... Pay-Per-View - Family Practice News - HighBeam Research

Merck & Co cuts AIDS drug prices to LDCs.(Brief article)  -  Feb 26, 2007
The prices of other formulations of Stocrin and Merck's other HIV/AIDS drug, Crixivan (indinavir sulfate), remain unchanged. ... Free with registration - Pharma Marketletter - AccessMyLibrary.com

Press Release: Data on Investigational HIV Compounds Presented at …  -  Feb 25, 2005
PR Newswire; September 18, 1998 ; 700+ words ... ... dosing regimens of its HIV protease inhibitor, Crixivan(R) (indinavir sulfate), in combination with ... Pay-Per-View - PR Newswire - HighBeam Research

International Pharmacopoeia: fourth edition.(Recent Publications, …  -  Jan 1, 2007
New monographs for the following antiretroviral substances have been published in the Fourth edition: didanosine, indinavir sulfate, nelfinavir mesilate, ... Free with registration - WHO Drug Information - AccessMyLibrary.com

Article: Lost in translation.(consumer advertising)(Column) - Medical...  -  Mar 1, 2005
Human Health Marketing division of Merck & Co., Inc., to create a number of new promotional pieces for their HIV product, Crixivan (indinavir sulfate). ... Pay-Per-View - Medical Marketing & Media - HighBeam Research

Ambrilia Sells HIV Product To Merck For Up To $232M.  -  Oct 13, 2006
...(indinavir sulfate), which it markets worldwide; the non-nucleoside reverse transcriptase inhibitor (NNRTI) efavirenz, which it markets in some countries ... Pay-Per-View - BIOWORLD Today - Factiva, from Dow Jones

CMI.(MEDIA) | Article from Medical Marketing & Media | HighBeam …  -  Jun 1, 2005
Human Health Marketing division of Merck & Co., Inc., to create a number of new promotional pieces for their HIV product, Crixivan (indinavir sulfate). ... Pay-Per-View - Medical Marketing & Media - HighBeam Research

Press Release: New Clinical Study Results Indicate Higher Early …  -  Apr 11, 2007
A) (Indinavir sulfate) in triple combination with two other AIDS medications showed ... completed six months of treatment. The triple combination reduced ... Pay-Per-View - PR Newswire - HighBeam Research

Press Release: MIGENIX Reports Second Quarter Fiscal Year 2007 …  -  Dec 13, 2006
A) (Indinavir sulfate) in triple combination with two other AIDS medications showed ... completed six months of treatment. The triple combination reduced ... Pay-Per-View - PR Newswire - HighBeam Research

Annex 8: proposal to waive in vivo bioequivalence requirements for...  -  Apr 1, 2006
...weak acid ([pK.sub.a]4.4, ibuprofen 400 mg 5.2) (a) indinavir sulfate 400 mg low low, weak acid ([pK.sub.a] 4.8) iopanoic acid 500 mg (2) isoniazid 300 ... Free with registration - Technical Report Series - AccessMyLibrary.com

ISENTRESS, raltegravir, van MSD als eerste integraseremmer …  -  Dec 31, 2007
Raltegravir is een onderdeel van de geschiedenis van MSD in het HIV-onderzoek, wat de ontwikkeling van CRIXIVAN ® (indinavir sulfate), een (PI); ... apothekersnieuws.nl

Netherlands Corporate News - ISENTRESS van MSD als eerste …  -  Dec 24, 2007
Raltegravir is een onderdeel van de geschiedenis van MSD in het HIV-onderzoek, wat de ontwikkeling van CRIXIVAN(R) (indinavir sulfate), een (PI); ... Netherlands Corporate News - Netherlands Corporate News (persbericht)

ISENTRESS® (raltegravir) van MSD als eerste integraseremmer …  -  Nov 23, 2007
Raltegravir is een onderdeel van de geschiedenis van MSD in het HIV-onderzoek, wat de ontwikkeling van CRIXIVAN® (indinavir sulfate), een (PI); STOCRIN®, ... Hiv Vereniging Nederland

Brand Names/Synonyms:
Indinavir Sulfate is also known by the following brand names and/or synonymsCompound J; Crixivan; Indinavir; Indinavir Sulfate; Indinavir [Usan]

Drug Category:
Indinavir Sulfate is categorized under the following by the FDA: Anti-HIV Agents; ATC:J05AE02

Dosage Forms:
Oral capsules

Absorption:
Rapidly absorbed

Interactions:
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Chemical IUPAC Name:
1-[2-hydroxy-4-[(2-hydroxy-2,3-dihydro-1H-inden-1-yl)carbamoyl]-5-phenyl-pentyl]-4-(pyridin-3-ylmethyl)-N-tert-butyl-piperazine-2-carboxamide





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