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InversineThis page contains recent news articles, when available, and an overview of Inversine but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.Overview: Inversine (when available) Mecamylamine is a potent, oral antihypertensive agent and ganglion blocker, and is a secondary amine. Mecamylamine is indicated for the management of moderately severe to severe essential hypertension and in uncomplicated cases of malignant hypertension. Mecamylamine reduces blood pressure in both normotensive and hypertensive individuals. A small oral dosage often produces a smooth and predictable reduction of blood pressure. Although this antihypertensive effect is predominantly orthostatic, the supine blood pressure is also significantly reduced. Mecamylamine crosses the blood-brain and placental barriers. For the treatment of moderately severe to severe essential hypertension and in uncomplicated cases of malignant hypertension Mechanism Of Action: Mecamylamine is a ganglionic blocker which prevents stimulation of postsynaptic receptors by acetylcholine released from presynaptic nerve endings. The hypotensive effect of Mecamylamine is attributed to reduction in sympathetic tone, vasodilation, and reduced cardiac output, and is primarily postural. News Articles on Mecamylamine Targacept Inc. Reports Operating Results (10-Q) - Nov 6, 2009 We acquired rights to Inversine in August 2002. Inversine is our only product approved for marketing by the US Food and Drug Administration, or FDA. ... GuruFocus.com Charlotte News, Weather, Sports | WCNC.com | Local Business - Apr 13, 2006 The company markets the hypertension drug Inversine, but has no other product revenue. In December, Targacept announced a four-year, $300 million research ... WCNC - WCNC (subscription) Targacept Named One of the Best Employers in North Carolina. - Mar 23, 2005 In addition to a marketed product, Inversine(R), Targacept has product candidates in clinical development for cognitive impairment, including Alzheimer's ... $4.95 - PR Newswire - ECNext In IPO, Targacept Will Look To Sell 5M Shares At $11 To $13 Each - Mar 17, 2006 Also in development is an anti-depressant compound derived from the active ingredient in Inversine, a product marketed by Targacept for the management of ... Subscription - VentureWire Alert - Dow Jones Financial Information Services Stock Market Update, IPO profiles, Earnings Call Transcripts,... - Jan 17, 2006 The Company also has one marketed product, Inversine, that is approved in the United States ... Inversine is currently the Company's only marketed product. ... 123Jump.com Antismoking Pill May Ease Depression ... Or Cause Suicidal Thoughts - Mar 13, 2008 Chantix, a pill that can help people quit smoking, and Inversine, a hypertension drug, appear to exert a soothing effect by blocking nicotine receptors in ... Wired News DEAL REDUCES FIRM'S NET LOSS ; COLLABORATION WITH … - May 10, 2007 The company markets Inversine, a hypertension drug but does not earn substantial revenue from the product. The company reported revenue of $2.1 million for ... Pay-Per-View - Winston-Salem Journal - ProQuest Archiver Article: Targacept, Vanda Decline in Trading Debuts - AP Online | … - Apr 12, 2006 It has FDA approval for one product, Inversine, which is approved for ... Its sales of Inversine, which it acquired in 2002, are declining and aren't ... Pay-Per-View - AP Online - HighBeam Research Autonomic Hyperreflexia - Symptoms, Diagnosis, Treatment of Autonomic... - May 29, 2008 ...include: Nifedipine (Procardia), Nitroglycerine, Phenoxybenzamine hydrochloride (Dibenzyline), Mecamylamine (Inversine), and Diazoxide (Hyperstat). ... New York Times Early Patch Use Helps Smokers Quit - Feb 1, 2006 All participants were given the smoking cessation drug Inversine. A month later, half the smokers who had worn the nicotine patches before quitting were ... FOXNews HOPE TAKES FEAR'S PLACE - Jun 5, 2007 Fox upped the dosage of one of the boy's medications, Risperdal; kept another, Tenex, the same; and added a third, Inversine. ... Pay-Per-View - St. Petersburg Times - ProQuest Archiver Targacept and AstraZeneca Announce Global License and Research … - Dec 28, 2005 Targacept has a marketed product, Inversine(R) (mecamylamine hydrochloride), product candidates in clinical development for cognitive impairment, ... Free with registration - PR Newswire - AccessMyLibrary.com TARGACEPT AIMS AT 5 AILMENTS ; AGREEMENT TO DEVELOP … - Jul 28, 2007 It markets one drug, Inversine, for hypertension, but it does not earn substantial revenue from the product. GlaxoSmithKline officials said they chose to ... Pay-Per-View - Winston-Salem Journal - ProQuest Archiver Ispronicline Joins Effort to Find Alzheimer's Cure - Jul 6, 2005 Targacept has a marketed product, Inversine(R) (mecamylamine hydrochloride), product candidates in clinical development for cognitive impairment, ... SeniorJournal.com Winston-Salem, NC-based biotech plans to go public. - Jan 18, 2006 Targacept markets the drug Inversine, a treatment for hypertension, but has no other source of product revenue. According to financial records in its SEC ... Free with registration - Winston-Salem Journal - AccessMyLibrary.com NET LOSS GETS WIDER ; DEALS WITH DRUG COMPANIES MAY HELP … - Aug 8, 2007 The company markets Inversine, a hypertension drug, but does not earn substantial revenue from the product. The company reported revenue of $2.8 million for ... Pay-Per-View - Winston-Salem Journal - ProQuest Archiver Targacept compounds show long-lasting improvement in cognition - Jul 5, 2005 Targacept has a marketed product, Inversine® ( mecamylamine hydrochloride ), product candidates in clinical development for cognitive impairment, ... i-newswire.com Targacept.(Triad)(Clinical report) | Article from Business North... - Nov 1, 2008 California-based Layton Bioscience for an undisclosed amount. Targacept plans to reformulate Inversine, which acts on nicotine receptors ... ... Pay-Per-View - Business North Carolina - HighBeam Research QuitPak enters pilot study - Feb 13, 2007 Until 1997 Merck marketed mecamylamine as a hypertension treatment under the name Inversine, but never pursued the smoking cessation potential that was ... In-PharmaTechnologist.com CHEMICAL SPILL FOUND AT TARGACEPT - Aug 24, 2005 It has about 72 employees and also markets a drug called Inversine, a treatment for hypertension. Woman sues institute over removal of brother's brain ... Pay-Per-View - Winston-Salem Journal - ProQuest Archiver Targacept Announces Positive Phase II Results for TC-1734 (AZD3480) … - May 17, 2006 Targacept has a marketed product, Inversine(R) (mecamylamine hydrochloride), product candidates in development for Alzheimer's disease and cognitive ... Free with registration - PR Newswire - AccessMyLibrary.com Targacept to Present at Pacific Growth Equities 2005 Life Sciences … - Jun 2, 2005 Targacept has a marketed product, Inversine(R) (mecamylamine hydrochloride), product candidates in clinical development for cognitive impairment, ... $4.95 - PR Newswire - ECNext Targacept to Report Second Quarter 2006 Financial Results on August... - Aug 9, 2006 Targacept has a marketed product, Inversine(R) (mecamylamine hydrochloride), product candidates in development for Alzheimer's disease and cognitive ... Genetic Engineering News - Genetic Engineering News (press release) Press Release: Targacept to Present at the CIBC Biotechnology … - Mar 31, 2005 Targacept has a marketed product, Inversine(R), product candidates in clinical development for cognitive impairment, including Alzheimer's disease and age ... Pay-Per-View - PR Newswire - HighBeam Research CASM, GRRF, HIMX, TRGT, TZOO, WIT Have Been Removed From … - May 11, 2006 It markets Inversine that is used for the management of moderately severe to severe essential hypertension in the United States. The company's lead product ... Free with registration - M2 Presswire - AccessMyLibrary.com Targacept Presents Promising Results at the 7th International... - Mar 29, 2005 Targacept has a marketed product, Inversine(R) (mecamylamine hydrochloride), product candidates in clinical development for cognitive impairment, ... $4.95 - PR Newswire - ECNext Targacept to Report Second Quarter 2006 Financial Results on August... - Aug 9, 2006 Targacept has a marketed product, Inversine(R) (mecamylamine hydrochloride), product candidates in development for Alzheimer's disease and cognitive ... prnewswire.com Targacept to Present at the Deutsche Bank 30th Annual Health Care … - Apr 28, 2005 Targacept has a marketed product, Inversine(R) (mecamylamine hydrochloride), product candidates in clinical development for cognitive impairment, ... $4.95 - PR Newswire - ECNext TARGACEPT REPORTS NET LOSS OF 5.5 MIL FOR FIRST QTR 2006. - Jul 1, 2006 Targacept has a marketed product, Inversine(R) (mecamylamine hydrochloride), product candidates in development for Alzheimer's disease and cognitive ... Entrepreneur Targacept Postpones Its Initial Public Offering. - Feb 28, 2005 In addition to a marketed product, Inversine(R), Targacept has product candidates in clinical development for cognitive impairment, including Alzheimer's ... $4.95 - PR Newswire - ECNext Press Release: Targacept to Present at the Deutsche Bank 30th Annual ... - Apr 28, 2005 Targacept has a marketed product, Inversine(R) (mecamylamine hydrochloride), product candidates in clinical development for cognitive impairment, ... Pay-Per-View - PR Newswire - HighBeam Research Targacept Reports First Quarter 2006 Financial Results. - May 25, 2006 Targacept has a marketed product, Inversine(R) (mecamylamine hydrochloride), product candidates in development for Alzheimer's disease and cognitive ... $4.95 - PR Newswire - ECNext NFLX, TRGT, TWP, UTK, VNDA, AASP Have Also Been Added To Naked … - Apr 25, 2006 It markets Inversine that is used for the management of moderately severe to severe essential hypertension in the United States. The company's lead product ... $4.95 - M2 Presswire - ECNext Washington Administrative Code - WAC 260-70-680 This section … - Mar 17, 2006 Zestril Losartan Hyzaar Mabuterol Mecamylamine Inversine Medetomidine Domitor Mefenamic Acid Ponstel Mestanolone Mesterolone Metaproterenol Alupent, ... Pay-Per-View - Washington Administrative Code - Loislaw Targacept to Report Second Quarter 2006 Financial Results on August... - Aug 2, 2006 Targacept has a marketed product, Inversine(R) (mecamylamine hydrochloride), product candidates in development for Alzheimer's disease and cognitive ... $4.95 - PR Newswire - ECNext Press Release: NFLX, TRGT, TWP, UTK, VNDA, AASP Have Also Been … - Apr 25, 2006 It markets Inversine that is used for the management of moderately severe to severe essential hypertension in the United States. The company's lead product ... Pay-Per-View - M2 Presswire - HighBeam Research Press Release: CASM, GRRF, HIMX, TRGT, TZOO, WIT Have Been … - May 11, 2006 It markets Inversine that is used for the management of moderately severe to severe essential hypertension in the United States. The company's lead product ... Pay-Per-View - M2 Presswire - HighBeam Research Press Release: Fundamental Review for Targacept, Inc. - M2 Presswire... - Dec 27, 2006 Targacept's products treat conditions related to Alzheimer's disease, depression, hypertension (Inversine), and pain by targeting nicotinic acetylcholine ... Pay-Per-View - M2 Presswire - HighBeam Research Brand Names/Synonyms: Inversine is also known by the following brand names and/or synonymsVersamine; Inversine; Revertina; Inversine hydrochloride; Mecamilamina; Mecamine; Mecamine hydrochloride; Mecamylamine Hydrochloride; Mekamin hydrochloride; Mekamine; Mevasin hydrochloride; Mevasine; 2-Methylamino-2,3,3-trimethylnorbornane; 2-Methylaminoisocamphane; 2-Norbornanamine, N,2,3,3-tetramethyl-; 2-Norbornanamine, N,2,3,3-tetramethyl-, hydrochloride; 3-Methylaminoisocamphane; 3-Methylaminoisocamphane hydrochloride Drug Category: Inversine is categorized under the following by the FDA: Antihypertensive Agents; Nicotinic Receptor Antagonist ATC:C02BB01 Dosage Forms: Tablets Absorption: Mecamylamine is almost completely absorbed from the gastrointestinal tract Interactions: [an error occurred while processing this directive] Chemical IUPAC Name: N,2,3,3-tetramethylnorbornan-2-amine |
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