Irbesartan

This page contains recent news articles, when available, and an overview of Irbesartan but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Irbesartan
(when available)

Pharmacology and use:
Irbesartan, an angiotensin II receptor antagonist similar to losartan and valsartan, is used alone or with hydrochlorothiazide to treat hypertension For the treatment of hypertension.

Mechanism Of Action:
Irbesartan antagonizes angiotensin II, the primary vasoactive hormone of the renin-angiotensin system, at the AT1 receptor subtype. As angiotensin II is vasoconstrictor which stimulates aldosterone secretion by the adrenal gland, blockage of its effects results in a decrease in systemic vascular resistance.

News Articles on Irbesartan

50 per cent Australians suffer from obesity, high BP  -  ‎Dec 11, 2009‎
...for 20 per cent of all drugs dispensed, with four off patent blood pressure-lowering medications like ramipril, perindopril, irbesartan and frusemide. ... TopNews United States

Generic Name: Irbesartan, Aprovel, Karvea  -  ‎Nov 11, 2009‎
Avapro (generic name: Irbesartan; brand names: Aprovel / Karvea) is an angiotensin II receptor antagonist used mainly for the treatment of high blood ... Pattaya Daily News

Patient's vital tablets sold out  -  ‎Nov 13, 2009‎
David Stott, of Hartshill, visited two pharmacies in Newcastle a fortnight ago, but neither was able to provide his prescription for Irbesartan Coaprovel, ... Stoke & Staffordshire

FibroGen Announces New Research in Anti-CTGF and HIF-PHI Therapeutic ...  -  ‎Nov 2, 2009‎
Raz I, the Collaborative Study Group: Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 ... Reuters

Strong earnings growth for Sanofi  -  ‎Oct 30, 2009‎
The antihypertensive Aprovel (irbesartan) increased 1.7% to 919 million euros, while the colorectal cancer drug Eloxatin (oxaliplatin) sank 44.3% to 193 ... Pharma Times

Sanofi-aventis Delivers a Solid Performance in Third Quarter 2009  -  ‎Oct 30, 2009‎
...on Plavix®/Iscover® (clopidogrel bisulfate) and Aprovel®/Avapro®/Karvea® (irbesartan), based on information provided to us by our alliance partner. ... Reuters

Sanofi-aventis mette a segno un solido risultato nel terzo trimestre 2009  -  ‎Nov 1, 2009‎
...con la quota degli utili al netto delle imposte nei mercati gestiti da BMS nell'ambito della partnership che riguarda Clopidogrel bisolfato e Irbesartan ... Tribuna Economica

Czy zmniejszenie aktywnoÅ›ci ukÅ‚adu renina-angiotensyna zmniejsza ryzyko ...  -  ‎Oct 26, 2009‎
W grupie eksperymentalnej stosowano: benazepryl (1 badanie), cilazapryl (1), enalapryl (6), ramipryl (4), fozynopryl (1), irbesartan (2), kaptopryl (1), ... Medycyna Praktyczna

Effects of losartan and irbesartan on serum uric acid in hypertensive...  -  Mar 9, 2005
Correspondence: Dr G Liu, Cardiovascular Institute and Fu Wai Hospital, Peking Union Medical College and Chinese Academy of Medical Science, Beijing 100037, ... Nature.com

… Improvement in Diastolic Function With Irbesartan and Atenolol...  -  Oct 25, 2005
The effects of the AT 1 receptor blocker irbesartan and the 1 blocker atenolol ... For irbesartan, relative changes in IVRT m and in septum thickness were ... Nature.com

Irbesartan Plus Low-Dose Propranolol Versus Low-Dose Propranolol …  -  May 8, 2007
Correspondence: Michael Schepke, MD, Department of Internal Medicine I, University of Bonn, Sigmund-Freud-Str. 25, D-53127 Bonn, Germany. ... Nature.com

Effect of irbesartan on erectile function in patients with hypertensio...  -  Mar 30, 2008
Correspondence: Dr M Baumhäkel, Kardiologie, Angiologie und Internistische Intensivmedizin, Klinik für Innere Medizin III, Universitätsklinikum des ... Nature.com

CORRECTED - UPDATE 1-US FDA staffer supports new use for Bristol …  -  Apr 16, 2007
The drug, first approved in 1997, is already approved to treat hypertension after use of either irbesartan or hydrochlorothiazide fails to help reach ... Reuters

Irbesartan in Heart Failure with Preserved Systolic Function (I- …  -  Nov 10, 2006
Approximately 50% of heart failure patients have a normal or near-normal left ventricular (LV) ejection fraction ("heart failure with preserved systolic ... Medscape

Effects of Irbesartan on the Growth and Differentiation of Adipocytes...  -  Apr 13, 2005
...* Department of Experimental Medicine, Section of Pharmacology L. Donatelli, and Second University of Naples, Naples, Italy. Correspondence: Michele D'Amico ... Nature.com

Irbesartan Fails to Improve Diastolic Heart Failure  -  Dec 4, 2008
WINSTON-SALEM, NC -- December 4, 2008 -- Irbesartan does not improve diastolic heart failure, according to a study published in the December 4 issue of the ... DG News

Irbesartan (Systemic).(Drug overview)  -  Aug 1, 2006
Irbesartan ( ir-be-SAR-tan) belongs to the class of medicines called angiotensin II inhibitor antihypertensives. It is used to treat high blood pressure ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Addition of Aliskiren to Irbesartan Improves Blood Pressure Control: ...  -  Nov 15, 2005
By Jill Stein. DALLAS, TX -- November 15, 2005 -- Renin inhibition with aliskiren in combination with irbesartan appears to provide increased suppression of ... DG News

Learn about Irbesartan from Consumer Reports Health.  -  Jan 5, 2007
Do not take irbesartan if you are pregnant. If you become pregnant while taking irbesartan, call ... Full Alert. Irbesartan is used alone or in combination ... consumerreports.org

Equivalent dosing of irbesartan, valsartan, and losartan identified...  -  Jan 1, 2008
Until 2005, irbesartan was the only ARB available on the Veterans Affairs (VA) healthcare system's national formulary. In 2005, irbesartan was removed from ... Free with registration - Formulary - AccessMyLibrary.com

Novel therapy in the management of hypertension: Preliminary …  -  Oct 24, 2005
Patients were randomized to once-daily aliskiren (150 mg, 300 mg, or 600 mg), irbesartan 150 mg, or placebo. The antihypertensive efficacy of aliskiren 150 ... Nature.com

Irbesartan/Hydrochlorothiazide is an Effective Treatment for Multiple...  -  May 23, 2007
By Jill Stein. CHICAGO, IL -- May 23, 2007 -- Treatment with a fixed-dose combination of irbesartan and hydrochlorothiazide (HCTZ) provides equal blood ... DG News

Irbesartan Ineffective in Treating Heart Failure With Preserved...  -  Nov 12, 2008
By Ed Susman. NEW ORLEANS -- November 12, 2008 -- There was no significant difference observed between the angiotensin receptor blocker irbesartan and ... DG News

Irbesartan/diuretic Combination Gets 80% of Women to Blood Pressure …  -  May 23, 2006
By Ed Susman. NEW YORK, NY -- May 23, 2006 -- A combination of antihypertensive drugs appears to help women with high blood pressure achieved their ... DG News

Effect of Three Months' Treatment With Irbesartan on Blood and Pulse ...  -  Jul 19, 2005
By Strutz, F; Bramlage, P; Paar, WD. Objectives: In hypertensive diabetics the cardiovascular risk is substantially increased. ... RedOrbit

How to take Irbesartan from Consumer Reports Health.  -  Jan 5, 2007
Do not take irbesartan if you are pregnant. If you become pregnant while taking irbesartan, call ... Full Alert. tell your doctor and pharmacist if you are ... consumerreports.org

New heart research path opens  -  Dec 16, 2008
Irbesartan appeared ideal because the drug reduces the hardening of tissue and showed promising results in heart failure patients whose hearts didn't pump ... Charleston Post Courier

Cost-Effectiveness of Irbesartan in Diabetic Nephropathy  -  May 10, 2005
Published studies over 10 years were reviewed on the cost-effectiveness of the use of irbesartan for treatment of advance overt nephropathy in patients with ... Diabetes In Control

Combo antihypertensives should be first line: nearly half of patients...  -  Jul 1, 2006
The second study looked at the effect of adding the angiotensin II receptor blocker (ARB) irbesartan to the diuretic hydrochlorothiazide (HCTZ). ... Free with registration - Family Practice News - AccessMyLibrary.com

Avapro HCT - Hydrochlorothiazide, Irbesartan - Medical Drug  -  Jul 1, 2008
Avapro HCT consists of two active ingredients known as irbesartan and hydrocholorothiazide. Both medicines are used to reduce blood pressure (BP) in ... Virtual Medical Centre - The Virtual Medical Centre

… Products for Human use summaries of positive opinion for Irbesartan...  -  Nov 17, 2006
The active substances are irbesartan and hydrochlorothiazide, an angiotensin ... Irbesartan and hydrochlorothiazide have synergistic blood pressure lowering ... Pay-Per-View - EMEA (European Medicines Agency) - Factiva, from Dow Jones

Karvezide - Hydrochlorothiazide, Irbesartan - Medical Drug  -  Jan 11, 2007
Everybody has blood pressure which is important to supply blood around the body, but when blood pressure becomes higher than normal, it may cause damage to ... Virtual Medical Centre - The Virtual Medical Centre

AF Clopidogrel Trial With Irbesartan for Prevention of Vascular Events  -  Nov 13, 2006
Description: The goal of the trial was to evaluate treatment with clopidogrel and aspirin compared with oral anticoagulant therapy among patients with ... Medscape

… 1A -adrenergic receptor Arg347Cys polymorphism and plasma irbesartan...  -  Mar 1, 2005
Plasma irbesartan concentrations were measured by use of HPLC-fluorescence. Results: BP therapeutic response was defined as baseline BP minus BP on the 28th ... Nature.com

Renal hemodynamic responses to renin–angiotensin blockade differ in …  -  Nov 2, 2006
The procedure was repeated fortnightly, with participants receiving irbesartan at doses of 75 mg/day for 4 weeks and 150 mg/day for the subsequent 4 weeks. ... Nature.com

Diabetic Nephropathy; Recent findings in diabetic nephropathy provide...  -  Jun 21, 2005
..."The aim of the Program for Irbesartan Mortality and Morbidity Evaluation ... "The Irbesartan in Patients with Type 2 Diabetes and Microalbuminuria (IRMA) ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

… has granted an approval for a CoAprovel /Karvezide (irbesartan/ …  -  Sep 6, 2006
..."The new irbesartan 300 mg plus HCTZ 25 mg combination is an interesting combination ... This fixed combination of irbesartan with HCTZ offers additive BP ... OnMedica

Diabetic Nephropathy; Irbesartan plus perindopril needed to reduce …  -  Nov 15, 2005
2005 NOV 15 - (NewsRx.com) -- Combined therapy with irbesartan plus perindopril is needed to reduce plasma aldosterone, proteinuria, and urinary TGF-beta1. ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

Bleeding Complications in Elderly Patients Following Acute Myocardial...  -  Nov 14, 2005
Of note, the ongoing Atrial Fibrillation Clopidogrel Trial With Irbesartan for Prevention of Vascular Events (ACTIVE) trial is comparing the combination of ... Archives of Internal Medicine

Article: FDA panel backs Avalide as first-line HT therapy.(Cardiovascu...  -  Jun 1, 2007
The second, a supportive trial, compared Avalide with irbesartan and HCTZ ... Avalide (irbesartan/ hydrochlorothiazide, from Sanofi Aventis and ... Pay-Per-View - Internal Medicine News - HighBeam Research

Abstract and Introduction  -  Jan 9, 2006
Irbesartan has previously been shown to effectively lower blood pressure (BP) ... Against this background, irbesartan may be of particular efficacy in the ... Medscape

Achieved SBP, ARB use reduce renal outcomes in diabetic nephropathy  -  Sep 20, 2005
Blockade of the renin-angiotensin system with irbesartan provides further renoprotection independent of the achieved SBP down to systolic pressures of 120 ... Medscape

Rationale and design of a study to evaluate management of proteinuria...  -  Mar 20, 2006
The Irbesartan in the Management of PROteinuric patients at high risk for Vascular Events ... 21 The angiotensin receptor blocker (ARB) irbesartan and the ... Nature.com

Irbesartan in scompenso a frazione di eiezione preservata non riduce ...  -  Dec 6, 2008
...in pazienti con insufficienza cardiaca e frazione di eiezione ventricolare sinistra preservata irbesartan non riduce significativamente gli eventi ... Pillole.org

Increasing telmisartan vs amlodipine dose in patients with hypertensio...  -  Apr 30, 2007
...(2001) The effect of irbesartan on the development of diabetic nephropathy in ... (2005) Enhanced renoprotective effects of ultrahigh doses of irbesartan in ... Nature.com

What blood-pressure level provides greatest renoprotection in...  -  Dec 14, 2005
Pohl et al. analyzed data from the Irbesartan Diabetic Nephropathy Trial, ... Patients were randomly assigned on a 1:1:1 basis to receive irbesartan 300 mg, ... Nature.com

Single Drug May Suffice to Lower Albumin Excretion Rate  -  Oct 16, 2007
The findings come from the IMPROVE [Irbesartan in the Management of Proteinuric ... “Thus, the combination of rampril plus irbesartan was no more effective ... Renal and Urology News

Initiating Treatment With Combination Angiotensin Receptor Blocker/ …  -  May 18, 2006
..."Combination therapy with irbesartan/hydrochlorothiazide therapy exposed fewer persons in the treatment population to severe hypertension," Dr. Neutel said ... DG News

Aliskiren Produces Sustained Blood Pressure Reduction Even After …  -  Jun 19, 2008
After a 7-day washout period and a 2-week placebo run-in period, 654 patients were randomised to aliskiren 150 mg, irbesartan 150 mg, or ramipril 5 mg once ... DG News

A Home Blood Pressure Monitoring Study Comparing the …  -  Jan 26, 2005
Results: Irbesartan/HCTZ produced greater reductions in average systolic BP (SBP) and diastolic BP (DBP) measured by HBPM than valsartan/HCTZ (SBP: -13.0 v ... Nature.com

I-PRESERVE: No reduction in mortality in patients with HF  -  Dec 1, 2008
The angiotensin receptor blocker irbesartan did not reduce the risk for ... Researchers for the Irbesartan in Heart Failure With Preserved Systolic Function ... Cardiology Today

Press Release: New Data From Satraplatin Sparc Phase 3 Investigational...  -  Jun 4, 2007
IDNT, irbesartan demonstrated a 20% relative risk reduction (p=0.0237) in the ... Irbesartan further demonstrated a 23% relative risk reduction (p=0.006) in ... Pay-Per-View - PR Newswire - HighBeam Research

Treatment Fails To Improve Common Form Of Heart Failure  -  Dec 5, 2008
One group received 300 milligrams of irbesartan, an anti-hypertensive ... The study showed treatment with irbesartan did not reduce the risk of death or ... Medical News Today - Medical News Today (press release)

COMUNICADO: La CE aprueba añadir CoAPROVEL(TM) / KARVEZIDE( …  -  Sep 6, 2006
Antihypertensive Efficacy of Irbesartan/HCTZ in Men and Women with the Metabolic ... Time course and extent of angiotensin II antagonism after irbesartan, ... elEconomista.es

New Drug Algorithms, New Drug Approvals, New Drugs  -  Jan 24, 2008
Efficacy and safety of irbesartan/HCTZ combination therapy as initial treatment for rapid control of severe hypertension. J Clin Hypertens (Greenwich). ... Medscape

… wird unter Kombinationsbehandlung auf Irbesartan-Basis besser...  -  Jul 12, 2005
Die Ergebnisse der Studien INCLUSIVE1 (IrbesartaN/HCTZ bLood pressUre reductionS in dIVErse ... SIMA2 (COmparative Study of Efficacy of Irbesartan/HCTZ with ... journalmed.de

Ipertensione: Aliskiren, il primo inibitore della renina  -  Apr 3, 2006
I partecipanti sono stati assegnati in modo random ad Aliskiren una volta al giorno ai dosaggi di 150mg, 300mg o 600mg, oppure ad Irbesartan ( Avapro ... XagenaSalute

FDA clears Avalide as initial high BP therapy.  -  Nov 26, 2007
The US Food and Drug Administration has approved the antihypertensive agent Avalide (irbesartan hydrochlorothiazide) as an initial treatment for ... $4.95 - Pharma Marketletter - ECNext

Inhibition of the renin–angiotensin system: is more better?  -  Sep 5, 2008
Increasing the dose of irbesartan from 300 to 900 mg per day further reduced proteinuria ... 11 In contrast, results of the Irbesartan in the Management of ... Nature.com

Pharmacokinetics and pharmacodynamics of the vasopeptidase inhibitor ...  -  Jul 6, 2005
...receptor antagonist (300 mg irbesartan) and a dual blockade of the RAS (150 mg irbesartan plus 10 mg ramipril) in sodium-replete normotensive subjects ... Nature.com

Combo antihypertensive backed for initial therapy.(NEWS FROM THE …  -  May 15, 2007
The second, a supportive trial, compared Avalide with irbesartan and HCTZ monotherapies in patients with moderate hypertension. ... Pay-Per-View - Family Practice News - HighBeam Research

Combination therapy works better for hypertension control.( …  -  Aug 1, 2006
The second study looked at the effect of adding the angiotensin II receptor blocker (ARB) irbesartan to the diuretic hydrochlorothiazide (HCTZ). ... Free with registration - Internal Medicine News - AccessMyLibrary.com

UN ANTIHIPERTENSIVO PROTEGE FRENTE AL DAÑO RENAL …  -  Mar 16, 2005
El doctor De �lvaro asegura que el efecto protector de irbesartan sobre el riñón ya se había puesto de manifiesto previamente en 2001, en el estudio IRMA 2 ... acceso.com

C-reactive protein as a predictor of total arteriosclerotic outcomes...  -  Jan 18, 2005
This hypothesis was tested in subjects enrolled in the multicenter, international Irbesartan Diabetic Nephropathy Trial (IDNT) cohort. ... Nature.com

… Monotherapy Respond to Fixed-Dose Combination of Irbesartan/ …  -  May 19, 2005
..."The response to irbesartan/hydrochlorthiazide combination therapy was not greatly influenced by the class of antihypertensive agent that the patient had ... DG News

The protective effect of the RAS inhibitor on diabetic patients with ...  -  Oct 2, 2008
In the longitudinal study involving the 6-month irbesartan treatment, we demonstrated that uVEGF levels decreased significantly in patients who achieved a ... Nature.com

L'irbésartan est rénoprotecteur chez les diabétiques de type 2 ayant...  -  Oct 25, 2005
Parving HH, Lehnert H, Bröchner- Mortensen J, et al, for the Irbesartan in ... The effect of irbesartan on the development of diabetic nephropathy in ... EBM Journal (Abonnement)

A Case of IgA Nephropathy: Conservative or Aggressive Therapy? <!-- …  -  Jan 1, 2008
I would increase the enalapril and then the irbesartan to the maximum tolerated by the patient without symptomatic hypotension, and in my experience some ... Nature.com

Sanofi-aventis; Bristol-Myers Squibb  -  Sep 6, 2006
..."Die neue Kombination Irbesartan 300 mg plus HCTZ 25 mg ist aufgrund der erwiesenen gemeinsamen Wirkung von Irbesartan und HCTZ eine interessante ... presseportal.de

Press Release: Powerful New Efficacy Data in Moderate and Severe …  -  Nov 19, 2007
Powerful New Efficacy Data in Moderate and Severe Hypertensive Patients Supports FDA Approval of AVALIDE(R) (Irbesartan-Hydrochlorothiazide) as the First ... Pay-Per-View - PR Newswire - HighBeam Research

What is the impact of blood-pressure control on cardiovascular events...  -  Oct 24, 2005
A post hoc analysis was performed on data from the Irbesartan Diabetic Nephropathy Trial (IDNT). From March 1996 to February 1999, this trial recruited ... Nature.com

Part of drug trial for patients with atrial fibrillation discontinued  -  Sep 6, 2005
Hamilton, Ontario, Canada - Study treatments for the ACTIVE W trial of the ACTIVE (Atrial Fibrillation Clopidogrel Trial with Irbesartan for Prevention of ... eurekalert.org

Novartis investigational renin inhibitor Aliskiren offers once-daily,...  -  Mar 11, 2005
1 indicates a significant dose-dependent response with the antihypertensive agent Aliskiren vs. placebo and another antihypertensive, irbesartan. ... Medical News Today - Medical News Today (press release)

Part of drug trial for patients with atrial fibrillation discontinued  -  Jul 9, 2005
Study treatments for the ACTIVE W trial of the ACTIVE (Atrial Fibrillation Clopidogrel Trial with Irbesartan for Prevention of Vascular Events) program have ... innovations report - Innovations-Report

Part of drug trial for patients with atrial fibrillation discontinued...  -  Sep 7, 2005
Study treatments for the ACTIVE W trial of the ACTIVE (Atrial Fibrillation Clopidogrel Trial with Irbesartan for Prevention of Vascular Events) program have ... Medical News Today - Medical News Today (press release)

Angiotensin II Antagonists - Therapeutic Benefits Spanning the …  -  Feb 9, 2006
The search strategy included combining the terms angiotensin II antagonists, angiotensin receptor blockers, losartan, candesartan, eprosartan, irbesartan, ... RedOrbit

ACE inhibitors not best for some hypertensive type 2 diabetics.(Metabo...  -  Apr 15, 2006
But for Dr. Schroeder, the most impressive evidence of the renoprotective benefits of ARB therapy comes from the Irbesartan Microalbuminuria Type 2 Diabetes ... Pay-Per-View - Family Practice News - Factiva, from Dow Jones

Novartis investigational renin inhibitor Aliskiren offers once-daily,...  -  Mar 10, 2005
1 indicates a significant dose-dependent response with the antihypertensive agent Aliskiren vs. placebo and another antihypertensive, irbesartan. ... Pay-Per-View - Hugin Press Release - Factiva, from Dow Jones

Cardiology; Researchers' findings advance cardiology research  -  Dec 27, 2005
Irbesartan did not abolish this response," the researchers reported. "Blockade of angiotensin II type 1 receptor with irbesartan preserves thyroxin-induced ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

Cardiovascular Disease; Alcoholic cardiomyopathy is prevented by …  -  Sep 19, 2006
..."Irbesartan prevented the alcohol-induced decreases in LV and myocyte contraction, relaxation, ... "With alcohol plus irbesartan, plasma Ang II, ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

Slowing nephropathy in hypertensive diabetes. | Article from Internal...  -  May 1, 2006
But for Dr. Schroeder, the most impressive evidence of the reno-protective benefits of ARB therapy comes from the Irbesartan Microalbuminuria Type 2 ... Pay-Per-View - Internal Medicine News - HighBeam Research

Cardiology; Reports describe recent advances in cardiology research  -  Mar 28, 2006
Irbesartan did not abolish this response," the researchers reported. "Blockade of angiotensin II type 1 receptor with irbesartan preserves thyroxin-induced ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

Does Aldosterone-to-Renin Ratio Predict the Antihypertensive Effect...  -  Feb 10, 2005
Both ACE inhibition with lisinopril and angiotensin receptor blockade with irbesartan decreased the ratio by 30% 22% and 43% 27% respectively, ... Nature.com

Gli antagonisti recettoriali dell'angiotensina II non devono essere...  -  Nov 17, 2008
I medicinali autorizzati con procedura centralizzata contenenti Irbesartan sono: Aprovel, Karvea, Irbesartan BMS e Irbesartan Winthrop. ... XagenaSalute

Jeder vierte Deutsche hat Bluthochdruck!  -  Aug 23, 2005
Dabei fällt, auch bei Problempatienten, mit modernen Kombinationen wie Irbesartan/HCT (CoAprovel®) in 7 von 10 Fällen der Blutdruck unter den Zielwert. ... Ärztliche Praxis Gesundheitszeitung

Hard-to-treat HT responded to simple regimen.(Cardiovascular Medicine)  -  Jul 15, 2005
The study, known as the Irbesartan/Hydrochlorothiazide Blood Pressure Reductions In Diverse Patient Populations (INCLUSIVE) trial, is the first large-scale ... Free with registration - Internal Medicine News - AccessMyLibrary.com

Renin inhibitor shows promise in trial  -  Mar 18, 2005
The 150mg dose was equivalent to irbesartan in its ability to lower blood pressure, while at higher doses aliskiren was significantly more effective in ... In-PharmaTechnologist.com

Abstract and Introduction  -  Nov 30, 2005
An elective-titration study of the comparative effectiveness of two angiotensin II-receptor blockers, irbesartan and losartan. Clin Ther. 1998; 20:398-409. ... Medscape

American heart association conference  -  Nov 21, 2008
Use of the angiotensin receptor blocker (ARB) irbesartan does not appear to reduce mortality rates in patients with heart failure (HF), US research suggests ... Healthcare Republic - Healthcare Republic

Abstract and Introduction  -  Dec 6, 2005
An elective-titration study of the comparative effectiveness of two angiotensin IIreceptor blockers, irbesartan and losartan. Clin Ther. 1998; 20:398-409. ... Medscape

Better representation of women in clinical renal trials needed  -  Nov 25, 2005
For example, the IDNT trial found that irbesartan benefits only men, whereas the IRMA 2 trial, which looked at the same drug, came to the opposite ... Medscape

Angiotensin blockade for diabetes: monitor microalbuminuria?(CLINICAL...  -  Feb 1, 2007
The effect of irbesartan on the development of diabetic nephropathy in patients with type 2 diabetes. N Engl J Med 2001; 345:870-878. ... $4.95 - Journal of Family Practice - ECNext

Erste kontrollierte Studie zu diastolischer Herzinsuffizienz  -  Sep 8, 2005
Mit Irbesartan läuft derzeit eine große Therapiestudie mit 4100 Patienten; ... Mit ihr wird Irbesartan in einer Dosierung von 300 Milligramm täglich im ... Ärzte Zeitung

Prävention und Therapie der diabetischen Nephropathie: Mäßiger Nutzen...  -  Oct 14, 2005
Irbesartan (300 mg/Tag) bewirkt jedoch im Vergleich zu Placebo nur eine ARR von 9,7 ... Tatsächlich beträgt beim Vergleich Placebo versus Irbesartan (300 ... Deutsches Ärzteblatt

Making Sense Out of an Alphabet Soup of Hypertension Treatment …  -  Apr 1, 2007
In fact, in the IrBesartan diabetic Nephropathy Trial (IBNT), which compared irbesartan with amlodipine, systolic blood pressure was only 1 mm Hg lower in ... $4.95 - Consultant - ECNext

The impact of angiotensin II receptor blocker potency on the clinical...  -  Oct 1, 2007
Higher-potency ARBs (candesartan, irbesartan, olmesartan, and telmisartan) may demonstrate improved 24-hour blood pressure control, suggesting that these ... $4.95 - Formulary - ECNext

GAO Rejects Bid Protest Filed by Bristol-Myers Squibb  -  Jan 21, 2005
On its face, the RFP limited this competition to two ARBs-Irbesartan (manufactured by BMS and Sanofi, marketed as Avapro) and Losartan (manufactured by ... Pay-Per-View - US Fed News - Factiva, from Dow Jones

Federal Register 2005 - 70 FR 43440 Summaries of Medical and Clinical  -  Jul 27, 2005
XR (mixed salts of a single-entity amphetamine product), AVANDIA (rosiglitazone), AVAPRO (irbesartan), RAPAMUNE (sirolimus), and ZOFRAN (ondansetron). ... Pay-Per-View - Federal Register 2005 - Loislaw

Diabetic Nephropathy; Findings in diabetic nephropathy provide new …  -  Dec 27, 2005
Study 1: Combined therapy with irbesartan plus perindopril is needed to reduce plasma aldosterone, proteinuria, and urinary TGF-beta1. ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

Persistent cough in elderly; The role of a home medicines review is...  -  Aug 31, 2006
Irbesartan 300mg hydro-chlorothiazide 12.5mg (Karv-ezide 300/12.5) 1 daily. ... The angiotensin-receptor blocker, irbesartan, is unlikely to be a cause of ... Pay-Per-View - Pharmacy News - Factiva, from Dow Jones

Press Release: Pilot Study of Ruboxistaurin Showed Favorable Effects...  -  Jun 13, 2005
Inhibition in Type 1 Diabetic Nephropathy and the recently ... Irbesartan in Type 2 Diabetic Nephropathy (I.D.N ... the American Diabetes Association ... ... Pay-Per-View - PR Newswire - HighBeam Research

Dual inhibition with losartan and aliskiren: a promising therapeutic...  -  Aug 4, 2008
7, 8 In the IMPROVE study, which randomized 405 patients with hypertension and diabetes to either ramipril plus irbesartan or ramipril plus placebo, ... Nature.com

Diagnosis of primary aldosteronism in a patient with an incidentally...  -  Feb 16, 2007
At presentation, medications included 300 mg irbesartan daily, 5 mg amlodipine daily and 100 mg sustained-release metoprolol daily. ... Nature.com

The benefits of renin–angiotensin blockade in hypertension are …  -  Mar 22, 2006
Irbesartan was clearly superior to amlodipine in this study, with a RR reduction of approximately 24% for the primary endpoints, despite almost identical ... Nature.com

How can the bleeding risk associated with warfarin therapy be reduced?  -  Aug 15, 2007
...as shown in ACTIVE-W (Atrial Fibrillation Clopidogrel Trial with Irbesartan for Prevention of Vascular Events), 5 which demonstrated that rates of ... Nature.com

Obat Gagal Jantung  -  Nov 17, 2008
Irbesartan sebenarnya digunakan terutama untuk obat antidarah tinggi, tapi juga untuk ... Pertemuan itu bertajuk Irbesartan in Heart Failure with Preserved ... MBM Tempo - MBM Tempo (abonemen)

Telmisartan-ë‘? 마리 새를 한번ì—? 잡는다  -  Jan 31, 2006
Angiotensin 수용체 차단제로는 telmisartan, irbesartan, losartan과 eposartan� 비�하였다. 연구결과 telmisartan과 irbesartan만� PPARγ 작용제 효과가 있었다. ... 메디�뉴스

Article: Prescribing chlorthalidone not as easy as ABC.(Cardiovascular...  -  Sep 15, 2007
Article: Irbesartan/HCTZ Fixed Combinations in Patients of ... ... IrbesartaN/hydroChlorothiazide (HCTZ) bLood pressure reductions In diVErse patient ... Pay-Per-View - Internal Medicine News - HighBeam Research

Brand Names/Synonyms:
Irbesartan is also known by the following brand names and/or synonymsAvalide; Avapro; CHEMBANK1635; Irbesarran; Irbesartan; Irbesartan [Usan:Inn]; Lrbesartan

Drug Category:
Irbesartan is categorized under the following by the FDA: Antihypertensive Agents; Angiotensin II Receptor Antagonists; ATC:C09CA04

Dosage Forms:
Oral tablets

Absorption:
60-80%

Interactions:
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Chemical IUPAC Name:
3-butyl-2-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-2,4-diazaspiro[4.4]non-3-en-1-one





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