Isoflurane

This page contains recent news articles, when available, and an overview of Isoflurane but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Isoflurane
(when available)

Pharmacology and use:
Isoflurane is a general inhalation anesthetic used for induction and maintenance of general anesthesia. It induces muscle relaxation and reduces pains sensitivity by altering tissue excitability. It does so by decreasing the extent of gap junction mediated cell-cell coupling and altering the activity of the channels that underlie the action potential. For induction and maintenance of general anesthesia

Mechanism Of Action:
Isoflurane induces a reduction in junctional conductance by decreasing gap junction channel opening times and increasing gap junction channel closing times. Isoflurane also activates calcium dependent ATPase in the sarcoplasmic reticulum by increasing the fluidity of the lipid membrane. Also appears to bind the D subunit of ATP synthase and NADH dehydogenase. Isoflurane also binds to the GABA receptor, the large conductance Ca2+ activated potassium channel, the glutamate receptor and the glycine receptor.

News Articles on Isoflurane

New Animal Drugs; Change of Sponsor; Isoflurane  -  ‎Dec 28, 2009‎
...(FDA) is amending the animal drug regulations to reflect a change of sponsor for an abbreviated new animal drug application (ANADA) for isoflurane, USP, ... Trading Markets (press release)

Arch Neurol. 2009;66(12):1572.  -  ‎Dec 14, 2009‎
Shivering is a thermoregulatory response to low ambient temperature, isoflurane, or epidurally administered anesthetic agents. ... Archives of Neurology

Neurology students present projects  -  ‎Dec 13, 2009‎
...asking how different mutations affected macular degeneration in canines and how isoflurane affects cocaine-associated memories in rats. ... The Daily Evergreen

Single Celled Organism Helps In Understanding How Anesthesia Works  -  ‎Dec 23, 2009‎
...both inhaled anesthetics, like desflurane, halothane, isoflurane, sevoflurane, and xenon; and intravenous anesthetics, like propofol and etomidate. ... Medical News Today (press release)

Castration: Swiss scientist criticises isoflurane use  -  ‎Nov 12, 2009‎
A scientist from the University of St Gallen, Switzerland has claimed that male piglet castration under isoflurane anaesthesia is 'not justifiable' under ... PigProgress.net

Anesthesia: Could Early Use Affect the Brain Later?  -  ‎Nov 3, 2009‎
In a separate area of research, Xie at Massachusetts General tested another anesthetic, isoflurane, on a culture of human brain cells. ... TIME

Piramal's critical care business looking at $100m sales  -  ‎Nov 3, 2009‎
Inhalation anaesthetics are gasses that possess anaesthetic qualities like halothane, isoflurane, desflurane, sevoflurane and enflurane. ... Daily News & Analysis

Peeping Tom Town Hall Meeting To Be Held Friday  -  ‎Oct 23, 2009‎
When police searched his home, marijuana plants, hundreds of child pornography images and videos along with a liquid anesthetic called isoflurane were found ... Northern Arizona Today

Chemical Spill at St Albans Hospital  -  ‎Oct 23, 2009‎
Two crews from St Albans arrived at the scene at around 8.45am after isoflurane, which comes in a liquid form but is administered as a vapour for ... Advertiser 24

Bursack: Dementia showed up after stay in hospital  -  ‎Nov 7, 2009‎
He's especially suspicious of one commonly used anesthetic, isoflurane, as a possible culprit. There is much more work to be done before anyone can say that ... In-Forum

Wastage of Supplies and Drugs in the Operating Room  -  ‎Oct 22, 2009‎
Volatile anaesthetics and the atmosphere: atmospheric lifetimes and atmospheric effects of halothane, enflurane, isoflurane, desflurane and sevoflurane. ... Medscape

Piramal Healthcare acquires NY based Pain Management Co, Minrad Intl  -  Dec 23, 2008
Piramal is a leading producer of halothane and isoflurane, while Minrad's product portfolio of inhalation anaesthetics consists of isoflurane, enflurane and ... Reuters India

Anaesthetic linked to Alzheimer's  -  Feb 7, 2007
The anaesthetic isoflurane is linked to cell death. ... They found isoflurane boosts the activity of an enzyme called capase, which plays a major part in ... BBC News

Safety fears over laughing gas  -  Aug 12, 2007
For instance, animal studies suggest that isoflurane or propofol can encourage the protein build-up in the brain that leads to Alzheimer's disease and other ... New Scientist

Isoflurane Shown Superior to Sevoflurane and Desflurane after Cardiac...  -  Oct 24, 2005
By Mike Fillon. ATLANTA, GA -- October 24, 2005 -- A study presented here at the American Society of Anesthesiologists (ASA) Annual Meeting shows that use ... DG News

Gender-specific response to isoflurane preconditioning in focal...  -  Jul 28, 2006
This work was supported by NS49210, NS33668, NS20020, NR03521, and OHSU Medical Research Foundation Seed Grant. Correspondence: Dr SJ Murphy, ... Nature.com

Anaesthetics linked to Alzheimer's  -  Feb 8, 2007
..."Our biophysical study shows clearly with the help of the state-of-the-art technology that inhaled anaesthetics isoflurane and halothane are not good." ... TVNZ

RXElite Holdings 'surprised' by Minrad's move  -  Sep 13, 2008
Minrad in June launched a direct selling effort for its sevoflurane and isoflurane anesthesia products in the US veterinary market. Buffalo News

Cardioprotection; Isoflurane cardioprotection is triggered by ROS and...  -  Apr 12, 2005
According to published research from the United States, "We determined whether isoflurane can confer delayed cardioprotection in the adult rat by triggering ... Pay-Per-View - Science Letter - Factiva, from Dow Jones

Common anaesthetic isoflurane can kill brain cells  -  Jan 17, 2007
New York, Jan 17 The commonly used anaesthetic isoflurane could kill brain cells and raise the risk of Alzheimer's, suggests a new study questioning the ... earthtimes.org

Anaesthetics are linked to higher Alzheimer's risk  -  Oct 26, 2006
The scientists found that two anaesthetics that are inhaled by patients - halothane and isoflurane - and the injected drug propofol encouraged the clumping ... Pay-Per-View - Scotsman - Factiva, from Dow Jones

… College of Wisconsin, Milwaukee; Isoflurane cardioprotection is...  -  Apr 13, 2005
..."Isoflurane conferred delayed cardioprotection 24 hours later at a ... "Nitrite and nitrate content in isoflurane-treated hearts was 1.5-fold higher than in ... Pay-Per-View - Biotech Week - Factiva, from Dow Jones

Ischemia; Isoflurane induced intracellular Ca2+ accumulation,...  -  Jan 10, 2005
2005 JAN 10 - (NewsRx.com & NewsRx.net) -- Researchers have investigated the impact of isoflurane during simulated ischemia/reoxygenation on intracellular ... Pay-Per-View - Pharma Business Week - Factiva, from Dow Jones

On-site, real-time Isoflurane monitor in Hospitals  -  Mar 28, 2007
The InfraRan, a portable, mid-infrared specific vapour analyser, designed for easy, on-site measurement of Isoflurane in the 0-30ppm range, ... Processing Talk

… States Code of Federal Regulations - 21 CFR § 529.1186 Isoflurane.  -  Jul 11, 2006
...(ii) Dogs: For induction of surgical anesthesia: 2 to 2.5 percent isoflurane (with oxygen) for 5 to 10 minutes. For maintenance of surgical anesthesia: 1.5 ... Pay-Per-View - United States Code of Federal Regulation... - Loislaw

Ischemia; Isoflurane induced intracellular Ca2+ accumulation,...  -  Jan 16, 2005
2005 JAN 16 - (NewsRx.com & NewsRx.net) -- Researchers have investigated the impact of isoflurane during simulated ischemia/reoxygenation on intracellular ... Pay-Per-View - Heart Disease Weekly - Factiva, from Dow Jones

Anaesthesia and Alzheimer's  -  Apr 28, 2008
Bin Zhang, Yuanlin Dong, Rudolph Tanzi, Zhongcong Xie, and colleagues examined this possibility with commonly used inhalation anaesthetics isoflurane ... Science Centric

Doc's license yanked after he dozed in OR  -  Jul 26, 2007
12, 2006, he inhaled Isoflurane while on his lunch break at Children's Hospital. Ho told his supervisors he was having a panic attack, according to the ... Pay-Per-View - Boston Herald - ProQuest Archiver

Neurology; Hippocampal neurons studied, isoflurane preconditioning …  -  Oct 25, 2005
..."Isoflurane preconditions neurons to improve tolerance of subsequent ... "Because isoflurane increases intracellular Ca2+ concentrations and Ca2+ is ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

RxElite Announces Preferred Contract Status Awarded for Their …  -  Apr 10, 2008
Sevoflurane is the most commonly used anesthetic gas in the United States and Isoflurane continues to be used widely in anesthesia practice. ... marketwire.com

… 43967 New Animal Drugs; Change of Sponsor; Isoflurane 21 CFR Parts  -  Aug 3, 2006
71 FR 43967 New Animal Drugs; Change of Sponsor; Isoflurane 21 CFR Parts 510 and 529 August 3, 2006 AGENCY: Food and Drug Administration, HHS. ... Pay-Per-View - Federal Register 2006 - Loislaw

Anesthesia; Isoflurane, N2O induce higher cardiac blood flow than …  -  Sep 20, 2005
They concluded, "Isoflurane and nitrous oxide induce a higher MBF than pentobarbital. Isoflurane also induces a higher ejection fraction in healthy rats." ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

… of Aβ Peptide Interaction with Isoflurane, Propofol, and Thiopental...  -  Oct 13, 2007
The reported anesthetic concentration was 6 times higher than a clinically relevant concentration; however, the actual concentration of isoflurane was 8−10 ... Environmental Science & Technology

Federal Register 2006 - 71 FR 8859 Request for Information on Waste …  -  Feb 21, 2006
Isoflurane, desflurane, and sevoflurane are commonly used for anesthesia ... NIOSH has not yet developed RELs for isoflurane, desflurane, and sevoflurane. ... Pay-Per-View - Federal Register 2006 - Loislaw

Frequently asked questions about anesthesia and surgery  -  May 5, 2008
Sevoflurane and Isoflurane are anesthetic gases; Propofol is an intravenous induction agent. 3. What is induction? It is the process of taking an animal ... Buzzle

MINRAD International, Inc. Announces Q3 2007 Financial Results.  -  Nov 13, 2007
Revenues were limited during the first nine months of 2007 due to the manufacturing of both isoflurane and sevoflurane on our isoflurane line (as opposed to ... Free with registration - PR Newswire - AccessMyLibrary.com

Common Anesthetic Induces Alzheimer's-associated Changes In Mouse …  -  Nov 14, 2008
..."These are the first in vivo results indicating that isoflurane can set off a ... Last year the MGH team showed that applying isoflurane to cultured neural ... sciencedaily.com

Anesthesia; Effects of isoflurane on gastrointestinal motility...  -  Sep 13, 2005
2005 SEP 13 - (NewsRx.com) -- The effects of isoflurane on gastrointestinal motility have been clarified in a rat model. "In pre-clinical studies, ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

Medical College of Wisconsin, US Recent studies involving Medical …  -  Jan 2, 2007
..."We tested the hypothesis that isoflurane preconditioning is triggered by Erk1/2 ... PD 098059 administered before, but not after, isoflurane abolished this ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

Common anaesthetic induces Alzheimer's-associated changes in mouse …  -  Nov 13, 2008
...'These are the first in vivo results indicating that isoflurane can set off a ... Last year the MGH team showed that applying isoflurane to cultured neural ... Science Centric

Memorial Sloan-Kettering Cancer Center, New York C; Memorial Sloan- …  -  Jan 2, 2007
..."In animals breathing isoflurane balanced by air, tumor pO2 at fixed positions decreased rapidly within 1-2 min of probe positioning but remained stable ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

Aceto Corporation Announces a 50% Increase in Second Quarter …  -  Feb 8, 2007
Mr. Schwartz continued, "In addition to our announcement regarding isoflurane, we continue to make progress towards acquiring additional products to ... Free with registration - Business Wire - AccessMyLibrary.com

Cardiology; Anesthetic preconditioning occurs when protein kinase …  -  Sep 19, 2006
..."We tested the hypothesis that isoflurane preconditioning is triggered by Erk1/2 ... PD 098059 administered before, but not after, isoflurane abolished this ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

Common Anesthetic May Induce Cell Death, Generation Of Alzheimer's- …  -  Feb 9, 2007
Previous studies have shown that applying the anesthetic isoflurane to cultured ... "Our studies have shown that isoflurane may induce a vicious cycle of ... Medical News Today - Medical News Today (press release)

Painkillers' Surprising Legacy Is More Pain  -  Jun 23, 2008
In a series of in vitro experiments, Dr. Ahern and colleagues showed that anesthetics such as propofol (Diprivan) and isoflurane (Forane) bind directly to ... MedPage Today

Common anesthetic may induce cell death, generation of Alzheimer's- …  -  Aug 2, 2007
Previous studies have shown that applying the anesthetic isoflurane to cultured ... "Our studies have shown that isoflurane may induce a vicious cycle of ... innovations report - Innovations-Report

Cardiology; Different effects of preconditioning suggest different...  -  Nov 8, 2005
..."Reactive oxygen species are an important mediator in isoflurane-induced ... However, the increase observed in the isoflurane group was not different from ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

Florida eye exam gets results  -  Nov 17, 2008
As a next step, the researchers gave mice doses of isoflurane equivalent to ... Research is mixed on isoflurane, with some studies saying it's better than ... Boston Globe

Researchers studying connection between delirium and dementia - The …  -  Feb 12, 2007
One of those papers studied the effect of isoflurane , the drug most commonly used to ... When isoflurane was "given" to cultured brain cells in the lab, ... Boston Globe

Cardiology; Reports advance knowledge in cardiology research  -  Dec 20, 2005
Study 1: Isoflurane does not mimic ischemic preconditioning in decreasing ... "Reactive oxygen species are an important mediator in isoflurane-induced ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

Anesthetic Linked to Alzheimer's Risk  -  Apr 26, 2007
The Harvard study raises questions about the safety of isoflurane, ... "To me, a big dose of isoflurane mimics a stroke or a bang to the head, and you don't ... DentalPlans.com

Does anaesthesia make pain worse?  -  Jul 8, 2008
Mice anaesthetised with isoflurane showed greater swelling in ears exposed to an irritant chemical than mice exposed to sevoflurane. ... Scotsman

Anesthesia; IV anesthetics restore cerebral autoregulation; volatile ...  -  Jul 26, 2005
After the induction, anesthesia was maintained by isoflurane (one ... Isoflurane anesthesia induced a significant increase in cerebral blood velocity. ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

University of California, San Francisco; New findings in the area of ...  -  Nov 16, 2005
..."Isoflurane preconditions neurons to improve tolerance of subsequent ... "Because isoflurane increases intracellular Ca2+ concentrations and Ca2+ is ... Pay-Per-View - Biotech Week - Factiva, from Dow Jones

Cardiology; High-dose propofol during CPB decreases markers of …  -  Oct 24, 2006
ZY Xia and colleagues, Wuhan University, wrote, "After the induction, anesthesia was maintained with an inspired concentration of isoflurane 1-3.5% (Group ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

Prana's Compound Featured in Annals of Neurology  -  Nov 18, 2008
The study published in the November edition of Annals of Neurology shows that the administration of the anesthetic gas isoflurane can spur the production of ... Bloomberg

Anesthetic induces Alzheimer's changes  -  Nov 25, 2008
..."These are the first results indicating that isoflurane can set off a ... "This study cannot tell us about the long-term effects of isoflurane ... United Press International

Anesthetic Linked to Alzheimer's Risk  -  Jan 15, 2007
The Harvard study raises questions about the safety of isoflurane, ... "To me, a big dose of isoflurane mimics a stroke or a bang to the head, and you don't ... HealthCentral.com

Controlling Early Emergence Among Craniotomy Patients: Presented at …  -  Oct 22, 2007
Dr. Bhagat and colleagues enrolled 150 patients with supratentorial tumours treated with standard isoflurane anaesthesia. From the beginning of dural ... DG News

News tips from the Journal of Neuroscience  -  Feb 6, 2007
The volatile anesthetic isoflurane can boost apoptosis and amyloid-â (Aâ) accumulation ... Treatment of naive human H4 neuroglioma cells with 2% isoflurane ... eurekalert.org

Flint Journal | Flint, MI Newspaper - MLive.com  -  Jan 24, 2008
Isoflurane is a colorless gas with a mild ether odor that decreases pain, ... Isoflurane usually is delivered through a mask worn by the patient. ... MLive.com

The Why Files | 2. Anesthesia: deadly to fast-developing young brain...  -  Dec 14, 2006
Isoflurane is a common anesthetic that has caused cell deaths in animal studies. ... Adding midazolam, a relative of valium, to isoflurane produced more ... Why Files

Anesthetics, General (Systemic).(Drug overview)  -  May 1, 2006
...(For inhalation anesthetics (enflurane, halothane, isoflurane, ... These effects do not occur with small doses of enflurane, isoflurane, or methoxyflurane. ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

MINRAD International, Inc. Announces Q1 2007 Financial Results.  -  May 15, 2007
By changing between the production of isoflurane and sevoflurane on the same line, ... Approximately two months of the production in the isoflurane active ... Free with registration - PR Newswire - AccessMyLibrary.com

Anesthesia-related hypotension in a small-animal practice: this …  -  Jan 1, 2006
Vaporizer settings during maintenance were 1.5% to 2% for isoflurane and 2% to 3% for sevoflurane. Oxygen flow rates were 800 ml/min for animals less than ... Free with registration - Veterinary Medicine - AccessMyLibrary.com

Transient focal cerebral ischemia induces a dramatic activation of...  -  Sep 26, 2007
Rats were anesthetized in a chamber with 5% isoflurane in 100% oxygen. ... The inspired isoflurane concentration was reduced to 1.5% to 2% . ... Nature.com

Anesthetics, General (Systemic).  -  Oct 27, 2005
...(For inhalation anesthetics (enflurane, halothane, isoflurane, ... These effects do not occur with small doses of enflurane, isoflurane, or methoxyflurane. ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Effects of anesthesia on the heart  -  Oct 29, 2008
For instance, isoflurane resulted in a prolonged QT interval in LQT2 but not ... Also noted is that isoflurane and propofol were especially proarrhythmic in ... The Hindu

Refractory status epilepticus.(Review Article)  -  Oct 1, 2006
Regardless of seizure type, isoflurane and desflurane consistently stopped ... Isoflurane in the management of status epilepticus after surgery for lesion ... Free with registration - Neurology India - AccessMyLibrary.com

Perioperative local anaesthetic in young paediatric patients undergoin...  -  Aug 10, 2007
Anaesthesia was maintained with isoflurane throughout the surgical procedure. Although this regimen is commonly used, the anaesthetists may, based on their ... Nature.com

MINRAD International, Inc. Announces Q2 2007 Financial Results  -  Aug 14, 2007
The potential revenue from additional sevoflurane sales was reduced by the production of both isoflurane and sevoflurane on our isoflurane active ... Genetic Engineering News - Genetic Engineering News (press release)

Magnetic Resonance Imaging; Method offers noninvasive approach to …  -  Apr 18, 2005
Regional myocardial blood flow measurements were carried out, and the effects of isoflurane at two different concentrations and ketamine/xylazine anesthesia ... Pay-Per-View - Health & Medicine Week - Factiva, from Dow Jones

In this Issue - ACS Chemical Biology (ACS Publications)  -  Jul 21, 2006
Like other isoflurane-based anesthetics, H-diaziflurane is nontoxic, ... Future studies with this compound and other isoflurane derivatives will facilitate ... Environmental Science & Technology

Press Release: Prana's Compound Featured in Annals of Neurology. - PR...  -  Nov 18, 2008
The study published in the November edition of Annals of Neurology shows that the administration of the anesthetic gas isoflurane can spur the production of ... Pay-Per-View - PR Newswire - HighBeam Research

Magnetic Resonance Imaging; Method offers noninvasive approach to …  -  Apr 18, 2005
Regional myocardial blood flow measurements were carried out, and the effects of isoflurane at two different concentrations and ketamine/xylazine anesthesia ... Pay-Per-View - Pain & Central Nervous System Week - Factiva, from Dow Jones

Cardiology; Techniques provide noninvasive assessment of perfusion …  -  Apr 18, 2005
The scientists continued, "In addition, 6 mice with myocardial infarction were studied under isoflurane anesthesia (HR 397±7 bpm). The perfusion maps showed ... Pay-Per-View - Health & Medicine Week - Factiva, from Dow Jones

Press Release: MINRAD International, Inc. Announces Q2 2007 Financial...  -  Aug 14, 2007
The potential revenue from additional sevoflurane sales was reduced by the production of both isoflurane and sevoflurane on our isoflurane active ... Pay-Per-View - PR Newswire - HighBeam Research

Cardiology; Techniques provide noninvasive assessment of perfusion …  -  Apr 19, 2005
The scientists continued, "In addition, 6 mice with myocardial infarction were studied under isoflurane anesthesia (HR 397±7 bpm). The perfusion maps showed ... Pay-Per-View - Science Letter - Factiva, from Dow Jones

Cardiology; Techniques provide noninvasive assessment of perfusion …  -  Apr 18, 2005
The scientists continued, "In addition, 6 mice with myocardial infarction were studied under isoflurane anesthesia (HR 397±7 bpm). The perfusion maps showed ... Pay-Per-View - Pain & Central Nervous System Week - Factiva, from Dow Jones

Press Release: MINRAD International, Inc. Announces Q3 2007 Financial...  -  Nov 13, 2007
Revenues were limited during the first nine months of 2007 due to the manufacturing of both isoflurane and sevoflurane on our isoflurane line (as opposed to ... Pay-Per-View - PR Newswire - HighBeam Research

Cardiology; Techniques provide noninvasive assessment of perfusion …  -  Apr 24, 2005
The scientists continued, "In addition, 6 mice with myocardial infarction were studied under isoflurane anesthesia (HR 397±7 bpm). The perfusion maps showed ... Pay-Per-View - Medical Devices & Surgical Technology... - Factiva, from Dow Jones

University of Wurzburg; Techniques provide noninvasive assessment of ...  -  Apr 20, 2005
The scientists continued, "In addition, 6 mice with myocardial infarction were studied under isoflurane anesthesia (HR 397±7 bpm). The perfusion maps showed ... Pay-Per-View - Biotech Week - Factiva, from Dow Jones

Cardiology; Techniques provide noninvasive assessment of perfusion …  -  Apr 18, 2005
The scientists continued, "In addition, 6 mice with myocardial infarction were studied under isoflurane anesthesia (HR 397±7 bpm). The perfusion maps showed ... Pay-Per-View - Cardiovascular Week - Factiva, from Dow Jones

Magnetic Resonance Imaging; Method offers noninvasive approach to …  -  Apr 24, 2005
Regional myocardial blood flow measurements were carried out, and the effects of isoflurane at two different concentrations and ketamine/xylazine anesthesia ... Pay-Per-View - Heart Disease Weekly - Factiva, from Dow Jones

Magnetic Resonance Imaging; Method offers noninvasive approach to …  -  Apr 19, 2005
Regional myocardial blood flow measurements were carried out, and the effects of isoflurane at two different concentrations and ketamine/xylazine anesthesia ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

Role Of Anesthetics In Alzheimer's Disease  -  Jan 28, 2007
The inhaled halothane and isoflurane had the most potent interaction with AB peptides causing the highest levels of AB aggregation. ... Medical News Today - Medical News Today (press release)

Granisetron and Ondansetron for Prevention of Nausea and Vomiting in ...  -  Jan 8, 2005
After tracheal intubation, anaesthesia was maintained with 66% nitrous oxide and 1 to 3% (inspired concentration) isoflurane in oxygen. ... RedOrbit

NPIL buys Rhodia business for £7m  -  Jan 17, 2005
Abbott is the global market leader for isoflurane with a 41% share. The source said the company would relocate the production of the two products to Ennore ... ICIS

Link suggested between anaesthetic and Alzheimer's  -  Feb 12, 2007
In a recent edition of the Journal of Neuroscience, scientists from Massachusetts General Hospital (MGH) suggest that use of isoflurane can enhance the ... Craegmoor News

DISCOVERIES: NEW SCIENCE FINDINGS  -  Jan 23, 2007
The commonly used anesthetic isoflurane can lead to the death of brain cells and ... "To me, a big dose of isoflurane mimics a stroke or a bang to the head, ... Pay-Per-View - Chicago Tribune - ProQuest Archiver

Two-step amplification of the human PPT sequence provides specific …  -  Oct 20, 2006
For in vivo imaging, mice were anesthetized with 1.5–2.5% isoflurane and D-luciferin (Xenogen Corporation, Alameda, CA) was injected into the peritoneal ... Nature.com

Drug Therapy; Spinal cord washout of volatile anesthetics compared to...  -  Apr 2, 2005
Exposure to a very small (0.025 MAC) concentration of isoflurane over the same ... "Isoflurane, but not halothane, significantly increased the amount of ... Pay-Per-View - Obesity, Fitness & Wellness Week - Factiva, from Dow Jones

Drug Therapy; Spinal cord washout of volatile anesthetics compared to...  -  Mar 29, 2005
Exposure to a very small (0.025 MAC) concentration of isoflurane over the same ... "Isoflurane, but not halothane, significantly increased the amount of ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

Cardioprotection; Study elucidates beneficial cardioprotective...  -  Apr 4, 2005
Rats received either the anesthetic gas xenon, the volatile anesthetic isoflurane or as positive control ischemic preconditioning (IPC) during 3 5-minute ... Pay-Per-View - Proteomics Weekly - Factiva, from Dow Jones

Angiology; Milrinone may be more useful than catecholamines for …  -  Jan 2, 2005
Researchers have investigated the effects of dopamine, dobutamine, amrinone and milrinone on regional blood flow in isoflurane anesthetized dogs. ... Pay-Per-View - Heart Disease Weekly - Factiva, from Dow Jones

Cat euthanized improperly, shelter complaint says  -  Feb 2, 2007
Isoflurane is administered by putting the animal in a container with cotton or gauze soaked with the anesthetic. The animal can convulse and its death can ... San Diego Union - Tribune - San Diego Union Tribune

RxElite, Inc. Announces Implementation of Preferred Contract Awarded ...  -  Jul 7, 2008
Sevoflurane is the most commonly used anesthetic gas in the US and Isoflurane continues to hold share in the anesthetic gas market. ... CNNMoney.com

Long-Term Treatment of Rats with Haloperidol: Lack of an Effect on...  -  Aug 31, 2005
Rats were lightly anesthetized with isoflurane and half of the calculated drug volume was injected in each hind leg. Dosages were given once per month ... Nature.com

Intracerebral hemorrhage leads to infiltration of several leukocyte …  -  Mar 31, 2008
Mice were anaesthetized with 2% isoflurane in 24% oxygen and 74% nitrous oxide, administered through an anesthesia mask (Kopf, Tujunga, CA, USA). ... Nature.com

Une étude préliminaire montrerait un lien entre certains produits …  -  Mar 20, 2007
Les souris contrôles exposées à l'isoflurane montrent des problèmes de mémoire et d'apprentissage mais aucune augmentation de PAB. ... InformationHospitaliere.com

Les vétérinaires mettent en garde: pas de remise de narcotiques pour...  -  Dec 5, 2008
En outre, l'Isoflurane, produit utilisée pour l'anesthésie, peut avoir un effet néfaste sur l'environnement et le climat. Il s'agit d'un gaz à effet de ... presseportal.ch

ANESTHESIA MAY AFFECT MEMORY AFTER SURGERY  -  Jun 12, 2008
Gases like isoflurane and halothane lead to accumulation of beta amyloid, a compound that is thought to contribute to Alzheimer's disease. ... Pay-Per-View - The Sun - ProQuest Archiver

From Anesthetic Mechanisms Research to Drug Discovery  -  Mar 5, 2008
Shown are the stick structures of isoflurane, etomidate, desflurane, propofol, sevoflurane, and thiopental. White = H, gray = C, red = O, blue = N, ... Nature.com

Tracking kidney volume in mice with polycystic kidney disease by …  -  Jan 9, 2008
After scanning, mice were anesthetized with isoflurane, and kidneys were removed, ... Mice were anesthetized and ventilated with isoflurane in oxygen. ... Nature.com

Evoked Response Potential Markers for Anesthetic and Behavioral States  -  Jan 30, 2006
Under isoflurane, the ERP was nearly absent, except for a very late component which was concombinant with burst synchronization. The slowest responses were ... AJP-Regul Integr Comp Physiology...

CCTV-å?¥åº·é¢‘é?“-å?ŽåŒ—煤炭医学院附属医院  -  Jan 17, 2005
Effects of halothane, isoflurane and sevoflurane on calcium-related contraction in porcine coronary arteries. Acta Anaesthesiol Acand 1996;40:815-819 ... 央视国际

Avian medicine: Instill a perioperative protocol to lessen anesthetic,...  -  Oct 1, 2006
Most often isoflurane is the anesthetic of choice; however, sevoflurane is an ... 4 Additionally, isoflurane has been shown to decrease ionized calcium, ... DVM 360

Common anesthetics appear safe for developing fetal brain  -  Mar 10, 2005
Isoflurane is known to produce these actions in the adult brain but it had not been appreciated that such effects could also occur in the fetal brain, ... Medical News Today - Medical News Today (press release)

Coming Out of Anesthesia Not Mirror Image of Going Under  -  Jan 11, 2008
...so he and colleagues began investigating their role in anesthesia, using the inhaled anesthetics isoflurane (Forane) and sevoflurane (Ultane). ... MedPage Today

Pet owners have options in paying for procedures  -  Aug 28, 2007
Many of us use isoflurane, an inhalant anesthetic, to maintain anesthesia in dogs and cats. Isoflurane has a great safety profile, and, because it is a gas, ... Waterloo Record

RxElite Awarded Dual-Source Anesthetic Gas Contract by Surgical Care ...  -  Mar 31, 2008
RxElite was awarded the contract listing for all classes of trade for Sojournâ„¢ (Sevoflurane) and Terrellâ„¢ (Isoflurane). Sevoflurane is the most commonly ... marketwire.com

Brand Names/Synonyms:
Isoflurane is also known by the following brand names and/or synonymsAerrane; Compd 469; Compound 469; Ethane; Forane; Forene; Isoflurane; Isoflurane [Usan:Ban:Inn:Jan]; Isofluranum [Inn-Latin]

Drug Category:
Isoflurane is categorized under the following by the FDA: Anesthetics; General Anesthetics; ATC:N01AB06

Dosage Forms:
LIQUID

Absorption:
Not Available

Interactions:
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Chemical IUPAC Name:
2-chloro-2-(difluoromethoxy)-1,1,1-trifluoro-ethane





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