Itraconazole

This page contains recent news articles, when available, and an overview of Itraconazole but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Itraconazole
(when available)

Pharmacology and use:
Itraconazole is an imidazole/triazole type antifungal agent. Itraconazole is a highly selective inhibitor of fungal cytochrome P-450 sterol C-14 α-demethylation via the inhibition of the enzyme cytochrome P450 14α-demethylase. This enzyme converts lanosterol to ergosterol, and is required in fungal cell wall synthesis. The subsequent loss of normal sterols correlates with the accumulation of 14 α-methyl sterols in fungi and may be partly responsible for the fungistatic activity of fluconazole. Mammalian cell demethylation is much less sensitive to fluconazole inhibition. Itraconazole exhibits in vitro activity against Cryptococcus neoformans and Candida spp. Fungistatic activity has also been demonstrated in normal and immunocompromised animal models for systemic and intracranial fungal infections due to Cryptococcus neoformans and for systemic infections due to Candida albicans. For the treatment of fungal infections in immunocompromised and non- immunocompromised patients: Blastomycosis, pulmonary and extrapulmonary; Histoplasmosis; Aspergillosis and Onychomycosis

Mechanism Of Action:
Itraconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. As ergosterol is an essential component of the fungal cell membrane, inhibition of its synthesis results in increased cellular permeability causing leakage of cellular contents. Itraconazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride and/or phospholipid biosynthesis.

News Articles on Itraconazole

Study Finds Vfend A Good Alternative For Fungal Infection Prevention In ...  -  05 Jan 2010
Vfend (voriconazole) may be an effective alternative to Sporanox (itraconazole) in the prevention of fungal infection in myelodysplastic syndromes (MDS) ... The MDS Beacon

Amphibians Threatened with Extinction  -  ‎Jan 1, 2010‎
Often a treatment combining anti-fungal drugs (such as itraconazole) with heat is used on infected animals. It is suspected that some Bd-resistant frogs may ... Santa Barbara Independent

Widespread Crusted Lesions in a Patient With HIV—Diagnosis  -  ‎Dec 21, 2009‎
To control this opportunistic infection in HIV-1–infected individuals requires systemic antifungal therapy with amphotericin B or itraconazole together with ... Archives of Dermatology

FDA Sends Letter to Sanofi-Aventis Regarding Uroxatral Promotion  -  ‎Oct 28, 2009‎
...in patients with moderate or severe hepatic impairment and co-administration with potent CYP3A4 inhibitors (eg, ketoconazole, itraconazole, ritonavir). ... PharmaLive.com (press release)

Market Watch  -  ‎Nov 5, 2009‎
...ketoconazole, atazanavir, clarithromycin, indinavir, itraconazole, nefazodone, nelfinavir, ritonavir, saquinavir, or telithromycin). ... The Hospitalist Online

New drug for type 2 diabetes  -  ‎Oct 29, 2009‎
Interactions: Potentiated by strong CYP3A4/5 inhibitors (eg, ketoconazole, atazanavir, clarithromycin, indinavir, itraconazole, nefazodone, nelfinavir, ... Clinical Advisor

ХомеопатиÑ?та не може да Ñ?е Ñ?равнÑ?ва Ñ? itraconazole при лечението на кандидоза ...  -  ‎Oct 26, 2009‎
Itraconazole е значително по-ефективен от хомеопатичните Ñ?редÑ?тва за лечението на рекурентна вулвовагинална кандидоза, докладват авÑ?трийÑ?ки лекари в BJOG. ... DoctorBG.com

복지부, 당뇨병 단ì?¼ì œ 추가 투여시 급여ì ?ìš©  -  ‎Oct 22, 2009‎
...ì?´ë°–ì—?ë?„ '브ì?´íŽœë“œì£¼ì‚¬'와 '브ì?´íŽœë“œì •'ì?˜ 경우, 침습성 아스페르질루스ì¦?ì—? 훈기존주 ë˜?는 Itraconazole 주사제를 투여했으나 실패시 추가 투여하는 경우 급여가 ... 메디파나뉴스

다국ì ?제약사, ë³´í—˜ 급여 확대 '봇물'  -  ‎Nov 1, 2009‎
...한국화ì?´ìž? '브ì?´íŽœë“œì£¼ì‚¬'와 '브ì?´íŽœë“œì •'ì?˜ 경우, 침습성 아스페르질루스ì¦?ì—? '훈기존주' ë˜?는 'Itraconazole 주사제'를 투여했으나 실패한 경우 추가 투여시 요양 ... 메디파나뉴스

당뇨 단ì?¼ì œ 추가투여ì—? 보험…11월부터  -  ‎Oct 30, 2009‎
...브ì?´íŽœë“œì£¼ì‚¬'와 '브ì?´íŽœë“œì •'ì?˜ 경우, 침습성 아스페르질루스ì¦?ì—? 훈기존주 ë˜?는 Itraconazole 주사제를 투여했으나 실패한 경우 추가 투여시 요양급여가 ì?¸ì •ë?œë‹¤. ... 데일리팜

11월부터 헵세ë?¼-ë°”ë?¼í?¬ë£¨ë“œ êµ?체투여 ì?¸ì •  -  ‎Oct 30, 2009‎
Voriconazole 제제(품명: 브ì?´íŽœë“œì£¼ì‚¬, 브ì?´íŽœë“œì •)는 침습성 아스페르질루스ì¦?ì—?는 Amphotericin B deoxycholate(품명:훈기존주) ë˜?는 Itraconazole 주사제를 투여 ... 메디포뉴스

헵세ë?¼ì •·바ë?¼í?¬ë£¨ë“œì •, ë‘? 약제 êµ?체투여 ì?¸ì •  -  ‎Oct 22, 2009‎
...ë˜?한 '브ì?´íŽœë“œì£¼ì‚¬, 브ì?´íŽœë“œì •'ì?€ 침습성 아스페르질루스ì¦?ì—?는 Amphotericin B deoxycholate(품명: 훈기존) ë˜?는 Itraconazole 주사제ì?˜ 효과를 기대하기 어렵거나 ... 메디포뉴스

Antifungal pills could help treat asthma: study  -  Dec 29, 2008
Itraconazole, marketed as Sporanox by Johnson & Johnson unit Janssen ... Denning and colleagues compared itraconazole with a placebo among 58 men and women ... Reuters

Cytochrome P450 3A inhibitor itraconazole affects plasma concentration...  -  Feb 23, 2005
Background and Objective: Despite the belief that cytochrome P450 (CYP) 2D6 alone is responsible for the metabolism of risperidone, several studies suggest ... Nature.com

Anti-fungal drug stops blood vessel growth  -  Apr 30, 2007
The drug, itraconazole, already is FDA approved for human use, ... “We were surprised, to say the least, that itraconazole popped up as a potential blocker ... Hindu

… endophthalmitis resolving with itraconazole treatment without...  -  May 12, 2006
Treatment with itraconazole led to complete resolution of C. albicans endophthalmitis in both the vitrectomised and nonvitrectomised eye. ... Nature.com

New Drug Fights Deadly Fungal Infections  -  Jan 24, 2007
Another drug, Sporanox (itraconazole), affectsaspergillus, but is not well utilized by the body. Noxafil is a newer agent that does affectaspergillusand ... Washington Post

Learn about Itraconazole from Consumer Reports Health.  -  Jan 4, 2005
Itraconazole can cause congestive heart failure (condition in which the heart cannot pump enough ... Full Alert. Itraconazole capsules are used to treat ... consumerreports.org

P-glycoprotein as the Mediator of Itraconazole–Digoxin Interaction  -  Oct 1, 2006
The drug interactions involving azole antifungal agents can be divided into the following categories: 1) additive dangerous interactions, 2) modifications ... Journal of the American Podiatric...

Antiadrenal Ketoconazole Antifungal, systemic Fluconazole Itraconazole...  -  Aug 1, 2006
During clinical practice of itraconazole, cases of birth defects including ... Itraconazole should not be given to pregnant women or women who may become ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

HalcyGen Anti-Fungal SUBA-Itraconazole Successful In Second Clinical ...  -  Sep 11, 2007
HalcyGen Pharmaceuticals Limited (ASX: HGN) lead product anti-fungal drug SUBA-Itraconazole has successfully been evaluated in the second of two ... Medical News Today - Medical News Today (press release)

Itraconazole Side Effects from Consumer Reports Health.  -  Jan 4, 2005
Itraconazole can cause congestive heart failure (condition in which the heart cannot pump enough ... Full Alert. Itraconazole can cause congestive heart ... consumerreports.org

… (Lamisil) More Effective than Itraconazole (Sporanox) for Onychomyc...  -  Mar 7, 2006
By Bruce Sylvester. SAN FRANCISCO, CA -- March 7, 2006 -- Treatment of onychomycosis, the most common nail disease, in older patients is significantly more ... DG News

Posaconazole successful in treating fluconazole- and itraconazole- …  -  Feb 15, 2007
Alternative treatments include itraconazole and voriconazole (which may be ... Adults with MC unresponsive to fluconazole or itraconazole treatment were ... Aidsmap

… Enhancing Polymers for Improved Bioavailability of Itraconazole  -  Sep 27, 2008
Amorphous engineered particle compositions of itraconazole (ITZ) and potential concentration enhancing polymers, cellulose acetate phthalate (CAP) and ... Environmental Science & Technology

ICAAC-IDSA: Fungi Geneticist Warns of Sick Building Syndrome  -  Oct 29, 2008
He said the patients given the itraconazole had a "very significant benefit in quality of life," among 60% of the patients. They also relied on fewer ... MedPage Today

Antifungal Prophylaxis; Itraconazole prophylaxis effective in...  -  Nov 1, 2005
..."Direct comparison between fluconazole and itraconazole for this indication shows the superiority of itraconazole which was the only drug able to prevent ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

Does posaconazole prevent invasive fungal infections in patients with...  -  May 18, 2007
...(2007) Posaconazole vs. fluconazole or itraconazole prophylaxis in patients with ... Posaconazole is more effective than fluconazole or itraconazole at ... Nature.com

Leukemia; Itraconazole and caspofungin used as antifungal prophylaxis...  -  Mar 28, 2006
..."Of 200 patients, 192 were evaluable for efficacy (86 for itraconazole, ... Two patients in the itraconazole group and 4 in the caspofungin group died of ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

… Candidiasis; Study: Single-day oral itraconazole is effective...  -  Jan 1, 2005
2005 JAN 1 - (NewsRx.com & NewsRx.net) -- Single-day oral treatment with 400 mg orally administered itraconazole is safe and effective against acute ... Pay-Per-View - Obesity, Fitness & Wellness Week - Factiva, from Dow Jones

Efficacy and safety of itraconazole tablets versus itraconazole capsul...  -  Oct 1, 2006
Sponsored by Barrier Therapeutics. Onychomycosis is a common condition accounting for approximately half of all nail disorders. It is most commonly caused ... Free with registration - Journal of Drugs in Dermatology - AccessMyLibrary.com

Voriconazole: A highly potent treatment for fungal infections  -  Dec 16, 2008
The researchers analyzed the effect of itraconazole, fluconazole, amphotericin B and voriconazole versus 1763 yeasts isolated from samples obtained from 472 ... eurekalert.org

Anti-fungal Drug Block Angiogenesis  -  May 1, 2007
New Research at Johns Hopkins have discovered that in mice itraconazole reduced blood vessel growth by 67 percent compared to placebo. ... MedIndia

Key Milestone In Antifungal Treatment For Severe Asthma  -  Jun 16, 2005
Certainly our limited treatment experience with itraconazole suggests fewer admissions to hospital for asthma and reduced numbers of steroid courses." ... sciencedaily.com

Antifungals, Azole (Systemic).(Drug overview)  -  May 1, 2006
During clinical practice of itraconazole, cases of birth defects including ... Itraconazole should not be given to pregnant women or women who may become ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

The New England Journal Of Medicine Publishes Two Landmark Studies …  -  Jan 25, 2007
Fluconazole or Itraconazole Prophylaxis in Patients with Neutropenia (Cornely et ... In this study, NOXAFIL versus fluconazole/itraconazole demonstrated a ... Free with registration - PR Newswire - AccessMyLibrary.com

Seoul National University, South Korea; Researchers from Seoul...  -  Dec 5, 2006
Study 3: Itraconazole has been formulated with improved dissolution and oral absorption. ... Droplet size of itraconazole emulsion was kept constant both in ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

Key Milestone In Antifungal Treatment For Severe Asthma  -  Jun 19, 2005
Certainly our limited treatment experience with itraconazole suggests fewer admissions to hospital for asthma and reduced numbers of steroid courses.� ... i-newswire.com

Breakthrough fungal infections after allogeneic hematopoietic stem...  -  Jun 25, 2007
Fifty-four patients switched from itraconazole to voriconazole after starting ... These patients had started itraconazole on the day of stem cell infusion. ... Nature.com

Generic Drugs; Company begins shipping Itraconazole capsules  -  Mar 8, 2005
Eon Labs, Inc., (ELAB) announced that it began shipping Itraconazole 100 mg capsules, the generic equivalent to Sporanox capsules. ... Pay-Per-View - Science Letter - Factiva, from Dow Jones

Leishmaniasis; Itraconazole successfully treats cutaneous leishmaniasi...  -  Mar 14, 2006
..."Leishmaniasis is a disease produced by several species of protozoa of the Leishmania genus. These protozoa are injected into the human bloodstream by ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

Eon Labs starts shipping generic itraconazole in USA.(Eon Labs Inc.)(...  -  Feb 14, 2005
US generics firm Eon Labs says that it has begun shipping itraconazole 100mg capsules, the generic equivalent to Janssen Pharmaceutica's Sporanox capsules. ... $4.95 - Pharma Marketletter - ECNext

Side effects of antifungal drugs  -  Jul 16, 2007
Itraconazole – is prescribed if the disease is caused by molds or yeasts. ... Itraconazole is effective in 45 to 70 percent of people using it. ... Buzzle

Noxafil wins approval for the prevention of invasive Aspergillus,...  -  Nov 1, 2006
After 100 days, these figures were 5% for the posaconazole group and 11% for the fluconazole/itraconazole group. Reported side effects of posaconazole ... Free with registration - Internal Medicine News - AccessMyLibrary.com

Generic Drugs; Company begins shipping Itraconazole capsules  -  Mar 7, 2005
Eon Labs, Inc., (ELAB) announced that it began shipping Itraconazole 100 mg capsules, the generic equivalent to Sporanox capsules. ... Pay-Per-View - Health & Medicine Week - Factiva, from Dow Jones

Which oral antifungal is best for toenail onychomycosis?(CLINICAL …  -  Jul 1, 2007
At one of my practices, itraconazole was available at a reduced price, ... Griseofulvin, fluconazole, itraconazole, and terbinafine have all been used ... Free with registration - Journal of Family Practice - AccessMyLibrary.com

Nizoral Oral : Uses, Side Effects, Interactions, Pictures, Warnings &...  -  Sep 30, 2008
Itraconazole and ketoconazole may slow down how quickly your liver processes ... The amount of itraconazole and ketoconazole in your blood may increase and ... WebMD

Generic Drugs; Company begins shipping Itraconazole capsules  -  Mar 12, 2005
Eon Labs, Inc., (ELAB) announced that it began shipping Itraconazole 100 mg capsules, the generic equivalent to Sporanox capsules. ... Pay-Per-View - Obesity, Fitness & Wellness Week - Factiva, from Dow Jones

New dosage forms of itraconazole, moxifloxacin recommended for …  -  Jun 5, 2006
On 24 May 2006, import approval was granted to Janssen Pharma for Itrizole Oral Solution 1% (itraconazole) and to Alcon Japan for Vigamox Ophthalmic ... Pay-Per-View - Pharma Japan - Factiva, from Dow Jones

Eon Labs Begins Shipping Itraconazole Capsules.  -  Feb 9, 2005
LAKE SUCCESS, NY -- Eon Labs, Inc. (Nasdaq: ELAB) announced today that it began shipping Itraconazole 100mg capsules, the generic equivalent to Sporanox(R)* ... $4.95 - Business Wire - ECNext

유한양행, 한국얀센과 í•­ì§„ê· ì œ ê³µë?™ë§ˆì¼€íŒ…  -  Jan 24, 2008
...유한양행� "스��녹스만� 특수한 제제학� 기술� 통해 지용성 �트�코나졸(Itraconazole) 성분� 가지는 �수� 어려움� 극복했다"며 "투여 종료 후�� �염 ... 머니투��

Nail Fungus Products – Are they worthy?  -  Sep 29, 2006
Oral treatment include the use of Itraconazole (Sporanox), Fluconazole (Diflucan) or Terminafine (Lamisil). Of course if you prefer to go the natural way, ... Buzzle

Appeals Court Affirms that Eon Labs' Itraconazole Does Not Infringe …  -  Jun 13, 2005
LAKE SUCCESS, NY -- Eon Labs, Inc. (Nasdaq: ELAB) announced today that the United States Court of Appeals for the Federal Circuit unanimously affirmed the ... $4.95 - Business Wire - ECNext

Which oral antifungal is best for toenail onychomycosis?(CLINICAL …  -  Jul 1, 2007
At one of my practices, itraconazole was available at a reduced price, ... Griseofulvin, fluconazole, itraconazole, and terbinafine have all been used ... $4.95 - Journal of Family Practice - ECNext

HALCYGEN PHARMACEUTICALS IPO ENDS OVERSUBSCRIBED.  -  Jun 21, 2007
HalcyGen wants to develop two anti-infective drugs - an anti-fungal treatment called SUBA-Itraconazole and an antibiotic called Minocycline - which have ... $4.95 - AsiaPulse News - ECNext

Ketoconazole Oral : Uses, Side Effects, Interactions, Pictures,...  -  May 20, 2008
Sporanox (itraconazole) UK summary of product characteristics. Janssen-Cilag Ltd November, 2008. 3.Sporanox (itraconazole) Canadian prescribing information. ... WebMD

中央日報網路報-大陸國際  -  Aug 20, 2008
...包括一種抗癌葯物etoposide�和用來治療心臟病的atenolol, celiprolol, talinolol 防止高血壓的葯物,和部分抗生素iprofloxacin, levofloxacin, itraconazole等。 ... 中央日報

Systemic Antifungal Therapy for Cutaneous Infections in Children  -  Jul 24, 2006
Although itraconazole is also available in an oral solution, this is not approved for ... The dosage of itraconazole was adjusted according to body weight, ... Medscape

Aspergillus bronchitis in cystic fibrosis *.(Original Research:...  -  Jul 1, 2006
Oral liquid itraconazole, 200 mg bid, was started with an immediate clinical ... Two months after initiation of itraconazole therapy, IgE was 8.5 IU/mL and ... $4.95 - Chest - ECNext

Hematopoietic SCT in patients with a history of invasive fungal...  -  Dec 22, 2008
In January 2001, we introduced itraconazole and amphotericin B into the ... Itraconazole (n=20) and voriconazole (n=23) were given intravenously and ... Nature.com

Nailing a stubborn problem | Article from Jerusalem Post | HighBeam …  -  Mar 11, 2007
Either itraconazole or terbinafine can be taken daily for 12 weeks, or a higher dose of itraconazole can be taken for one week per month for three months. ... Pay-Per-View - Jerusalem Post - HighBeam Research

Echinocandins offer antifungal therapy with low toxicity, few drug...  -  May 15, 2005
Itraconazole leads the azole class in terms of potential interactions. ... Itraconazole can also have significant pH interactions. ... Free with registration - Internal Medicine News - AccessMyLibrary.com

An Emerging Extended-Spectrum Triazole Antifungal: Noxafil[R] ( …  -  Jun 1, 2006
Activities of Caspofungin, Itraconazole, Posaconazole, Ravuconazole, Voriconazole, ... In Vitro Activities of Posaconazole, Itraconazole, Voriconazole, ... Free with registration - Infectious Disease Alert - AccessMyLibrary.com

The use of terbinafine in the treatment of onychomycosis in adults...  -  May 1, 2005
Additionally, terbinafine has been reported to be superior to both itraconazole and fluconazole in comparative studies in the treatment of dermatophyte ... Free with registration - Journal of Drugs in Dermatology - AccessMyLibrary.com

Solar Storm Cycle Expected Next March  -  Apr 30, 2007
The drug, itraconazole, already is FDA approved for human use, ... “We were surprised, to say the least, that itraconazole popped up as a potential blocker ... ایران دیلی

Anidulafungin: an echinocandin antifungal for the treatment of...  -  Aug 1, 2006
...(25) Voriconazole and itraconazole both exhibited MI[C.sub.90] values of 0.12 ... Anidulafungin combined with itraconazole or voriconazole appeared to be ... $4.95 - Formulary - ECNext

Leukemia; Reports from the United States, India and Australia add new...  -  May 15, 2006
Study 1: Itraconazole and caspofungin both provided antifungal prophylaxis ... Two patients in the itraconazole group and 4 in the caspofungin group died of ... Pay-Per-View - Cancer Weekly - Factiva, from Dow Jones

ì§„ê·  알러지 있는 중ì¦? 천ì‹?환ìž?ì?˜ ì¦?ìƒ? 개선하는 효과 ë³´ì—¬  -  Dec 30, 2008
...진균� �한 피부�염 치료제� '스��녹스(Sporanox, itraconazole)'정제가 중� 천� 환�� �� 개선� 효과���는 연구결과가 29�� American Journal of ... ��리팜

www.exduco.net - Graduate schools and programs guide  -  May 4, 2007
The drug, itraconazole, already is FDA approved for human use, ... “We were surprised, to say the least, that itraconazole popped up as a potential blocker ... exduco.net

An Emerging Extended-Spectrum Triazole Antifungal: Noxafil[R] ( …  -  Jun 1, 2006
Activities of Caspofungin, Itraconazole, Posaconazole, Ravuconazole, Voriconazole, ... In Vitro Activities of Posaconazole, Itraconazole, Voriconazole, ... Pay-Per-View - Infectious Disease Alert - Factiva, from Dow Jones

Antifungal Drug Stops Blood Vessel Growth  -  Apr 27, 2007
The drug, itraconazole, already is FDA approved for human use, ... "We were surprised, to say the least, that itraconazole popped up as a potential blocker ... newswise.com

Literature review and case histories of histoplasma capsulatum var. …  -  Nov 1, 2007
Itraconazole treatment was started (400 mg/d), but it was switched to ... The clinical course was satisfactory, so itraconazole was lowered to 200 mg/d for ... Free with registration - Emerging Infectious Diseases - AccessMyLibrary.com

Spherics Presents Proof-of-Concept Studies Demonstrating Advantages …  -  Jun 21, 2005
The company expects to outlicense other products, such as itraconazole and ... "Itraconazole has low bioavailability due in part to low aqueous ... $4.95 - Business Wire - ECNext

Plasma Concentrations of Oral Oxycodone Are Greatly Increased in the ...  -  Jan 21, 2008
One patient in the 60–70 group was using 100 mg itraconazole daily. Because itraconazole is an effective inhibitor of CYP3A4 both in vitro and in vivo, ... Nature.com

Nailing a stubborn problem  -  Mar 11, 2007
Either itraconazole or terbinafine can be taken daily for 12 weeks, or a higher dose of itraconazole can be taken for one week per month for three months. ... Pay-Per-View - Jerusalem Post - ProQuest Archiver

Infection with Scedosporium apiospermum and S. prolificans, Australia....  -  Aug 1, 2007
Four patients with chronic lung disease were receiving itraconazole for treatment ... One patient was receiving itraconazole for Aspergillus spp. infection, ... $4.95 - Emerging Infectious Diseases - ECNext

Preventing invasive fungal infections: Results of two studies on …  -  Apr 1, 2007
Posaconazole vs fluconazole or itraconazole prophylaxis in patients with ... The second compared it with fluconazole or itraconazole in patients with ... $4.95 - Journal of Respiratory Diseases - ECNext

The keys to identifying and managing fungal infections of the lungs:...  -  Mar 1, 2005
The triazole antifungals include ketoconazole, itraconazole, fluconazole, and voriconazole. ... Itraconazole has unpredictable absorption from the GI tract, ... $4.95 - Journal of Respiratory Diseases - ECNext

Candida krusei fungemia in an unrelated allogeneic hematopoietic stem...  -  Apr 25, 2005
On the basis of susceptibility tests (resistance to fluconazole and itraconazole, intermediate sensitivity to voriconazole), therapy with Caspofungin was ... Nature.com

Halcygen completes first pivotal SUBA-itraconaole trial.  -  Oct 13, 2008
The study has demonstrated that SUBA-itraconazole in a "half-dose" format gives ... The registration strategy for SUBA-itraconazole is designed to compare ... $9.94 - Pharma Marketletter - Alacra Store

FDA Approves Noxafil(R) (Posaconazole) for Prevention of Invasive …  -  Sep 18, 2006
A reduction in proven and probable IFIs vs. fluconazole/itraconazole (2% vs. 8%). -- A reduction in breakthrough Aspergillus infections vs. ... DG News

Schering-Plough Announces FDA Approval Of NOXAFIL(R) ( …  -  Sep 19, 2006
A reduction in proven and probable IFIs vs. fluconazole/itraconazole (2 percent vs. 8 percent). -- A reduction in breakthrough Aspergillus infections vs. ... Medical News Today - Medical News Today (press release)

Improved anti-fungal drug targets oncology market.  -  Jun 16, 2008
HalcyGen's SUBA-Itraconazole formulation was licensed from Hospira to treat fungal infections. Under the terms of the license agreement, the Australian firm ... $9.94 - Pharma Marketletter - Alacra Store

Posaconazole demonstrates efficacy for prophylaxis of fungal infection...  -  Mar 1, 2007
Posaconazole vs. fluconazole or itraconazole prophylaxis in patients with neutropenia. New Eng J Med. 2007;356:348-359. ... $9.94 - Formulary - Alacra Store

Noxafil(R) (Posaconazole) Oral Suspension Approved in European Union …  -  Nov 9, 2006
A reduction in proven and probable IFIs vs. fluconazole/itraconazole [7/304 (2%) vs. 25/298 (8%), P =.0009]. -- A significant decrease in all cause ... DG News

Barrier Therapeutics Completes Patient Enrollment for Pivotal Phase 3...  -  Sep 28, 2007
Hyphanox is a unique 200 mg tablet formulation of itraconazole, ... Itraconazole is approved for the treatment of both onychomycosis and vaginal candidiasis ... marketwire.com

Clinical: The Basics - Diagnosis and treatment of cases of onychomycos...  -  Dec 2, 2005
Itraconazole is the most effective agent for the treatment of candidal ... Both terbinafine and itraconazole persist in the nail for a considerable period ... Free with registration - GP - AccessMyLibrary.com

Broad-spectrum activity of antifungals needs further study: no single...  -  Oct 15, 2007
..."Itraconazole is commercially available as a topical preparation in India, but we and others in the United States have been using oral itraconazole ... Free with registration - Ophthalmology Times - AccessMyLibrary.com

Fungal and Bacterial Infections: August 2006  -  Aug 10, 2006
With regard to Aspergillus, itraconazole was active against 94% of the 445 strains ... Conclusions: The study authors concluded that itraconazole was active ... Medscape

… et al., Clinical Study on the Efficacy and Safety of Intravenous...  -  May 23, 2006
SUMMARY: Itraconazole has a broad spectrum of activity against the most common ... Patients were treated with itraconazole intravenously for 2 weeks (200 mg ... �康・栄養ニュース

Rx FOR READERS  -  Aug 12, 2005
Itraconazole (Sporanox), an expensive drug, is not taken continuously. ... Concomitant use of ketoconazole or itraconazole with sildenafil (Viagra) results ... Pay-Per-View - Jerusalem Post - ProQuest Archiver

A study to determine the safety profile and maximum tolerated dose of...  -  May 22, 2006
Sometimes itraconazole is used, and more recently voriconazole has received a ... 4 Recently, a meta-analysis with itraconazole shows that it effectively ... Nature.com

New hope of curing amphibian plague  -  Nov 28, 2008
Even if implemented on a wide-scale, using itraconazole to protect frogs from chytridiomycosis would only be one strategy out of many. ... Mongabay.com

Antifungal Therapy; US FDA approves Schering-Plough's posaconazole …  -  Oct 18, 2006
There was also a decreased in all cause mortality at 100 days post-randomization in favor of Noxafil compared to fluconazole or itraconazole (14% vs. 21 %). ... Pay-Per-View - Biotech Week - Factiva, from Dow Jones

HalcyGen begins 2nd trial of anti-fungal.  -  Aug 13, 2007
Australia's HalcyGen Pharmaceuticals has begun second clinical study of its lead product, the anti-fungal drug SUBA-Itraconazole (based on Janssen ... $9.94 - Pharma Marketletter - Alacra Store

Antifungal Therapy; US FDA approves Schering-Plough's posaconazole …  -  Oct 20, 2006
There was also a decreased in all cause mortality at 100 days post-randomization in favor of Noxafil compared to fluconazole or itraconazole (14% vs. 21 %). ... Pay-Per-View - Drug Week - Factiva, from Dow Jones

Invasive Pulmonary Aspergillosis; Invasive pulmonary Aspergillosis in...  -  Jan 1, 2005
..."The neonate was treated successfully with combined therapy of intravenous amphotericin B deoxycholate and oral itraconazole aided by partial removal of the ... Pay-Per-View - Obesity, Fitness & Wellness Week - Factiva, from Dow Jones

Antifungal Drugs; Anion channel inhibitors enhance the anticandida …  -  Mar 28, 2006
In addition, larger amounts of amphotericin B and itraconazole remained in Candida cells in the presence of Pep2 or Hst5 due to the lower excretion." ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

Prophylaxis or treatment in coping with invasive fungal infections;...  -  Apr 24, 2006
Conventional therapy for IFI includes fluconazole, itraconazole and amphotericin B, and trial data with these agents have shown that early intervention can ... Pay-Per-View - Pharma Marketletter - Factiva, from Dow Jones

Invasive Pulmonary Aspergillosis; Invasive pulmonary Aspergillosis in...  -  Jan 2, 2005
..."The neonate was treated successfully with combined therapy of intravenous amphotericin B deoxycholate and oral itraconazole aided by partial removal of the ... Pay-Per-View - Heart Disease Weekly - Factiva, from Dow Jones

Antifungal Drug Stops Blood Vessel Growth. | Article from Ascribe...  -  Apr 27, 2007
The drug, itraconazole, already is FDA approved for human use, ... "We were surprised, to say the least, that itraconazole popped up as a potential blocker ... Pay-Per-View - Ascribe Higher Education News Service - HighBeam Research

Chemogenomic profiling on a genome-wide scale using reverse- …  -  Mar 4, 2005
...(b) Targets of itraconazole predicted by the MNI algorithm using the expression ... ERG11 (red), a known target of itraconazole, is the second most likely ... Nature.com

Posaconazole (Noxafil): a new triazole antifungal agent.(Pharmacology...  -  Apr 1, 2007
It is structurally related to itraconazole and has activity against Candida ... Itraconazole is active against Aspergillus species and resistant strains of ... Free with registration - Baylor University Medical Center... - AccessMyLibrary.com

New Potential Application For Suba-Itraconazolea In Oncology -...  -  Jun 12, 2008
SUBA-Itraconazoleä is a proprietary formulation of itraconazole that has been ... The current global market for itraconazole for the treatment of fungal ... Medical News Today - Medical News Today (press release)

Infliximab-induced disseminated histoplasmosis in a patient with...  -  Nov 29, 2007
Since completion of oral itraconazole therapy, urinary histoplasmosis antigen levels have been monitored every 6 months and have remained undetectable. ... Nature.com

HalcyGen Begins Second Study Of Anti-Fungal Drug - Anti-Fungal Drug …  -  Aug 8, 2007
HalcyGen Pharmaceuticals Limited (ASX: HGN) has begun its second clinical study of its lead product, anti-fungal drug SUBA-Itraconazole. ... Medical News Today - Medical News Today (press release)

Increased Liver Abnormalities With Voriconazole Prophylaxis Against …  -  May 24, 2006
Overall, 26 patients were treated with itraconazole 200 mg orally BID for 3 ... Aspergillus was isolated in 19% of patients in the itraconazole group and ... DG News

Pedicure caution and other onychomycosis tips.  -  Dec 1, 2007
Itraconazole is the choice in nondermatophyte mold infections of the nail. Two other drugs on the horizon "that may supersede itraconazole in this ... Entrepreneur

Cutaneous sporotrichosis of face: Polymorphism and reactivation after...  -  May 1, 2007
...sup] [9] Itraconazole is the treatment of choice for all forms of ... Fluconazole is less effective than itraconazole and is of value in patients intolerant ... Free with registration - Indian Journal of Dermatology, Venereolo... - AccessMyLibrary.com

Disseminated aspergillosis causing spinal cord compression in a...  -  Jul 1, 2007
Later itraconazole (4 mg/Kg-bid) was given for a month. He also received broad-spectrum antibiotics, namely imipenum, ciprofloaxacin and amikacin during the ... Free with registration - Neurology India - AccessMyLibrary.com

Breakthrough zygomycosis after voriconazole administration among …  -  Feb 19, 2007
14 Likewise, the results of in vitro activity for itraconazole against zygomycetes ... In vitro activities of posaconazole, itraconazole, voriconazole, ... Nature.com

광범위 병변-ë‘?부백선 등 발현ë•? 바로 사용  -  Aug 28, 2006
...본고�서는 가장 많� 사용�는 항진균제� itraconazole, terbinafine � fluconazole � 중심 ... Itraconazole� triazole계열� 광범위 항진균제로 백선, 칸디다�, ... 디지틀보사

Brand Names/Synonyms:
Itraconazole is also known by the following brand names and/or synonymsDRG-0044; ITC; ITCZ; ITR; ITZ; Itraconazol [Spanish]; Itraconazole; Itraconazole & Bovine Lactoferrin; Itraconazole & Nyotran; Itraconazole [Usan:Ban:Inn:Jan]; Itraconazolum [Latin]; Itrizole; Oriconazole; Sporal; Sporanos; Sporanox; Sporonox; Triasporn

Drug Category:
Itraconazole is categorized under the following by the FDA: Antiprotozoals; Antifungals; ATC:J02AC02

Dosage Forms:
100 mg capsules or as a liquid solution

Absorption:
The absolute oral bioavailability of itraconazole is 55%, and is maximal when taken with a full meal.

Interactions:
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Chemical IUPAC Name:
4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-(1-methylpropyl)-2,4-dihydro-1,2,4-triazol-3-one





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