Lamivudine

This page contains recent news articles, when available, and an overview of Lamivudine but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Lamivudine
(when available)

Pharmacology and use:
Lamivudine is a nucleoside reverse transcriptase inhibitor (NRTI) with activity against Human Immunodeficiency Virus Type 1 (HIV-1) and hepatitis B (HBV). Lamivudine is phosphorylated to active metabolites that compete for incorporation into viral DNA. They inhibit the HIV reverse transcriptase enzyme competitively and act as a chain terminator of DNA synthesis. The lack of a 3'-OH group in the incorporated nucleoside analogue prevents the formation of the 5' to 3' phosphodiester linkage essential for DNA chain elongation, and therefore, the viral DNA growth is terminated. For the treatment of HIV infection and chronic hepatitis B (HBV)

Mechanism Of Action:
Lamivudine is a synthetic nucleoside analogue and is phosphorylated intracellularly to its active 5'-triphosphate metabolite, lamivudine triphosphate (L-TP). This nucleoside analogue is incorporated into viral DNA by HIV reverse transcriptase and HBV polymerase, resulting in DNA chain termination.

News Articles on Lamivudine

GSK '제픽스' 투여…Virus ë?ŒíŒŒ 미확ì?¸, ë°”ë?¼í?¬ë£¨ë“œ 급여제한  -  05 Jan 2010
...ë°”ë?¼í?¬ë£¨ë“œì •1mg 불ì?¸ì •= 심í?‰ì›?ì—? 따르면 BMS ë°”ë?¼í?¬ë£¨ë“œ 1mgì?€ ì?¸ì •기준(고시 ì œ2008-28호, 08.5.1)ì—? ì?˜ê±° 'Lamivudine 고시 기준ì—? ì ?합한 성ì?¸(ë§Œ 16세 ì?´ìƒ?) ... 메디컬헤럴드

Treatment outcomes and plasma level of ritonavir-boosted lopinavir monotherapy ...  -  ‎Dec 23, 2009‎
LPV/r at 400/100 mg and lamivudine 150 mg were given twice daily. CD4 and HIV-1 RNA were monitored at week 0, 12, 24, and 48. LPV Cmin was assayed for the ... 7thSpace Interactive (press release)

Mali gets tool to detect bogus medicine  -  ‎Dec 31, 2009‎
...the HIV therapy of lamivudine, zidovudine and nevirapine; anti-malarial quinidine; and the antibiotic rifampicin, to treat tuberculosis and leprosy. ... UPI.com

TB, pregnancy, most common reasons for treatment changes in African study  -  ‎Dec 10, 2009‎
Rates and causes of treatment changes were reported for the three most common drug regimens: stavudine/lamivudine/nevirapine (d4T/3TC/NVP), taken by 32% of ... Aidsmap

Widespread Crusted Lesions in a Patient With HIV—Diagnosis  -  ‎Dec 21, 2009‎
The patient started antiretroviral therapy (zidovudine, 600 mg/d; lamivudine, 300 mg/d; and efavirenz, 600 mg/d) and treatment with amphotericin B (1 mg/kg ... Archives of Dermatology

Study Identifies Viread And Emtriva As The Preferred Initial Treatment For HIV ...  -  ‎Dec 10, 2009‎
...effective nucleoside reverse transcriptase inhibitors (NRTIs) than Ziagen (abacavir) and Epivir (lamivudine) as an initial combination therapy for HIV. ... The AIDS Beacon (blog)

SEXUALLY TRANSMITTED DISEASES:- THEIR NATURE AND CURE - THIRD PUBLICATION  -  ‎Dec 18, 2009‎
Examples of Anti-retroviral drugs are: Zidovudine (AZT or 31 Azido 31 deoxy thymidine) or retrovir, Nevirapine, Didanosine, Efavirenz, Lamivudine, Stavudine ... Modern Ghana

심í?‰ì›? 진료심사í?‰ê°€å§”, 7ê°œ 심ì?˜ì‚¬ë¡€ 공개  -  ‎Dec 30, 2009‎
...만성바ì?´ëŸ¬ìФ B형간염ì—? 제픽스를 전액본ì?¸ë¶€ë‹´ìœ¼ë¡œ 복용 중 Lamivudine 약제 내성 진단 하ì—? 헵세ë?¼ë¥¼ 투여하다가 ë°”ë?¼í?¬ë£¨ë“œ 1mgì?„ 변경 투여하면서, ... 데일리메디

Nhận biết viêm gan siêu vi  -  ‎Dec 17, 2009‎
Ä?iá»?u trị bằng các thuốc kháng virus như Lamivudine, Adefovir, Entecavir riêng rẽ hoặc phối hợp. Có thể dùng thêm các thuốc trợ gan mật, ngoài ra có thể tiêm ... Thanh Niên

AIDS Divisions of 2 Large Drug Makers Form Company to Focus on the Disease  -  ‎Nov 9, 2009‎
With headquarters in London, the company initially has a portfolio of 10 licensed drugs, including some of the earliest, like AZT and lamivudine, ... New York Times

Mylan Inc Subsidiary Matrix Laboratories Receives FDA  -  ‎Nov 13, 2009‎
FDA approval for the company's fixed-dose combination of Efavirenz, Lamivudine and Tenofovir Disoproxil Fumarate tablets for the treatment of HIV. ... TransWorldNews (press release)

Lamivudine, Entecavir Both Improved Prognosis in Hepatitis B-Related Acute-on ...  -  ‎Nov 2, 2009‎
BOSTON -- November 2, 2009 -- Both entecavir and lamivudine significantly improved the survival of patients with early- to midstage ... DG News

Generic Name: Lamivudine/Zidovudine  -  ‎Nov 11, 2009‎
Combivir (generic name: Lamivudine/Zidovudine) is used, alone or with other medicines, to slow down the progression of human immunodeficiency virus (HIV) ... Pattaya Daily News

Hepatitis B Immune Globulin Therapy May Improve Graft and Patient Survival ...  -  ‎Nov 2, 2009‎
In all, 101 of these patients received HBIG alone, 15 patients received lamivudine alone, 19 received both treatments, 304 received neither treatment, ... DG News

HIV/AIDS Update - Tentative Approval of Lamivudine and Tenofovir DF Fixed Dose ...  -  ‎Nov 6, 2009‎
Fixed dose combination products can help also help reduce costs associated with treatment for HIV infection. Lamivudine and tenofovir df are Nucleoside ... PharmaLive (press release) (subscription)

Is chronic hepatitis B curable?  -  ‎Nov 12, 2009‎
Therapy is done using interferon-a, oral lamivudine and oral adefovir. On therapy, the virus will still remain in the body, however, as mentioned earlier, ... DoctorNDTV

Generic Name: Tenofovir, emtricitabine  -  ‎Nov 11, 2009‎
Do not take Truvada if you are already taking Atripla, Combivir (lamivudine/zidovudine), Emtriva, Epivir or Epivir-HBV (lamivudine), Epzicom (abacavir ... Pattaya Daily News

Epzicom Associated With More Side Effects In HIV/AIDS Patients Than Truvada  -  ‎Nov 9, 2009‎
Alternatively, Epzicom is a combination therapy that contains Ziagen (abacavir) and Epivir (lamivudine). Viread and Ziagen were originally introduced to ... The AIDS Beacon (blog)

Combivir: The HIV Drug in Hasan's Shoe Box  -  ‎Nov 12, 2009‎
...and it contained the first-ever agent approved for the treatment of AIDS — zidovudine (better known as AZT) as well as lamivudine (3TC). ... TIME

Pfizer/GSK HIV Spin-Off ViiV Healthcare Debuts With Personalized Drugs in ...  -  ‎Nov 11, 2009‎
The other drug, Epizicom, combines abacavir and lamivudine. The US Food and Drug Administration last year updated the labeling for abacavir to include ... GenomeWeb Daily News

Shire's Vyvanse shows an impressive growth rate  -  ‎Nov 3, 2009‎
We think Shire's licensing portfolio, mainly consisting of HIV drug lamivudine, will deteriorate by 2010 as key patents are set to expire. ... Hemscott

GlaxoSmithKline, Pfizer Launches Specialist HIV Company  -  ‎Nov 4, 2009‎
...-ViiV Healthcare has 10 medicines currently available including therapies such as Epzicom/Kivexa (abacavir sulfate+lamivudine) and Selzentry/Celsentri ... CNNMoney.com

BARACLUDE® (entecavir) Demonstrated Greater Antiviral Efficacy Compared to ...  -  ‎Oct 31, 2009‎
Approximately one third of patients were previously exposed and resistant to lamivudine. The primary study endpoint was the mean change from baseline HBV ... Reuters

Postexposure Prophylaxis for HIV Infection  -  ‎Oct 28, 2009‎
The use of antiretroviral agents for postexposure prophylaxis that have activity against hepatitis B (including tenofovir, lamivudine, and emtricitabine) ... New England Journal of Medicine (subscription)

Coalescing purpuric plaques  -  ‎Nov 10, 2009‎
His medications included Combivir (lamivudine/zidovudine) and nelfinavir. A biopsy revealed increased spindle cells with vascular slits. ... Clinical Advisor

Combination Antiretroviral Therapy Effective At Reducing HIV Resistance In ...  -  ‎Oct 27, 2009‎
The researchers report that the combination drug regimen -- which involved the addition of a twice-daily dose of zidovudine and lamivudine over several days ... Science Daily (press release)

Telbivudine Safe and Effective in Suppressing Hepatitis B Over Very Long Term ...  -  ‎Nov 2, 2009‎
At the conclusion of the 2-year GLOBE study -- a phase 3 trial of telbivudine versus lamivudine in 1367 adults in which telbivudine demonstrated superior ... DG News

GlaxoSmithKline and Pfizer launch HIV joint venture  -  ‎Nov 5, 2009‎
ViiV Healthcare has 10 medicines currently available including therapies such as Epzicom/Kivexa (abacavir sulfate+lamivudine) and Selzentry/Celsentri ... Trading Markets (press release)

Gilead Sciences, Inc. Q3 2009 Earnings Call Transcript  -  ‎Oct 20, 2009‎
Supported by guideline endorsements for use in both naive and lamivudine experienced patients and a positive recommendation from the UK National Institute ... Seeking Alpha (blog)

Five-year follow up of genotypic resistance patterns in HIV-1 subtype C ...  -  ‎Oct 25, 2009‎
In contrast, the standard of care for all patients subsequently enrolled (2002-2007) included zidovudine/lamivudine (ZDV/3TC) (Group 2). ... 7thSpace Interactive (press release)

Majority of Hep B patients resistant to antiviral therapy  -  ‎Oct 22, 2009‎
...(83%) and were currently on adefovir (ADV) and lamivudine (LAM) (39%), LAM (16%), ADV plus entecavir (ETV), ETV monotherapy (12%) or ETV 1mg (11%). ... Gastroenterology Update

GlaxoSmithKline to allow Apotex continue manufacturing their drug in Rwanda  -  ‎Oct 20, 2009‎
...containing two molecules over which GSK has patent rights (zidovudine and lamivudine). GSK believes that CAMR is simple, straightforward and efficient. ... News-Medical.net

Canada approves ISENTRESS(R) for adults starting HIV treatment  -  ‎Oct 20, 2009‎
...in antiretroviral treatment-naïve HIV-1-infected adult subjects comparing raltegravir to efavirenz, both in combination with tenofovir and lamivudine. ... CNW Telbec (Communiqué de presse)

Fabricantes de medicamentos juntam divisões para produzir remédios para Aids  -  ‎Nov 13, 2009‎
Com sede em Londres, a empresa inicialmente tem um portfólio de 10 drogas licenciadas, incluindo alguma das mais antigas, como o AZT ea lamivudine, ... TÔSABENDO.COM

Evaluación del paciente con hepatitis B  -  ‎Oct 19, 2009‎
Longitudinal assessment of histology surrogate markers (FibroTest-ActiTest) during lamivudine therapy in patients with chronic hepatitis B infection. ... Intramed.net (Suscripción)

당신ì?„ 괴롭히는 만성B형간염, 얼마나 알고 있나?  -  ‎Oct 18, 2009‎
...ì?´í›„ 1990년대 후반ì—? 등장한 í•­ë°”ì?´ëŸ¬ìŠ¤ì œì?¸ ë?¼ë¯¸ë¶€ë”˜(lamivudine)ì?€ 부작용ì?´ 경미하고 B형 간염바ì?´ëŸ¬ìФì?˜ ì¦?ì‹?억제효과가 íƒ?월하며 하루 1회 먹는약으로 사용하기 ... 쿠키뉴스

Co-infection Nigeria : co-infection VIH/VHB et réponse au traitement  -  ‎Nov 4, 2009‎
...avaient démarré les ARV entre octobre 2004 et juin 2006 (stavudine ou zidovudine, lamivudine plus éfavirenz ou névirapine) avec un minimum de six mois ... vih.org

Comment les médicaments antirétroviraux ont transformé la vie des enfants ...  -  ‎Nov 4, 2009‎
Les ARV que nous disposons c'est essentiellement l'AZT, la stavudine, efavirenz, le nevirapine, lamivudine, le Viracept®. ... papamamanbebe.net

Oprichting ViiV Healthcare  -  ‎Nov 3, 2009‎
ViiV Healthcare brengt in Nederland 8 medicijnen op de markt, zoals Kivexa(R) (abacavir +lamivudine) en Celsentri(R) (maraviroc). ... Ezpress (persbericht)

Båž‹è‚?炎基金會發表å°?兒篩檢ã€?監控與轉診指引  -  ‎Oct 21, 2009‎
...局核准用於孩童慢性Båž‹è‚?炎åˆ?步治療的抗病毒藥物,adefovir用於12歲以上者ã€?entecavir用於16歲以上者ã€?干擾素α-2b用於12個月以上者ã€?lamivudine用於3歲以上者。 ... 臺灣新浪網

Megalakult a ViiV Healthcare  -  ‎Nov 3, 2009‎
...beleértve olyan terápiás készítményeket is, mint például az Epzicom/Kivexa (abacavir sulfate + lamivudine) és a Selzentry/Celsentri (maraviroc). ... Weborvos

Quick Search by Organization  -  ‎Oct 19, 2009‎
...une association antirétrovirale à doses fixes qui contient deux molécules pour lesquelles GSK détient les droits de brevet (zidovudine et lamivudine). ... Canada NewsWire (press release)

Le Canada approuve ISENTRESS(MC) pour les adultes commençant un traitement ...  -  ‎Oct 20, 2009‎
...jamais reçu de traitements antirétroviraux et comparant les traitements de raltégravir et d'efavirenz en combinaison avec le ténofovir et la lamivudine. ... CNW Telbec (Communiqué de presse)

… says China telbivudine data confirms drug's superiority over lamivu...  -  Mar 27, 2006
AG said new clinical data from China shows the superiority of hepatitis B treatment telbivudine after one year of use over commonly used lamivudine. ... Forbes

Ranbaxy gets tentative USFDA nod for AIDS drug Lamivudine  -  Jun 1, 2005
RANBAXY Laboratories Ltd (RLL) on Tuesday announced that it has received a tentative approval to manufacture and market Lamivudine tablets, 150 mg, ... Hindu Business Line

Is telbivudine superior to lamivudine for the treatment of patients...  -  Mar 19, 2008
Telbivudine is an excellent first-line therapy for treatment-naïve patients with chronic hepatitis B who, at baseline, have predictive factors of a good ... Nature.com

… is adefovir dipivoxil plus lamivudine for the treatment of lamivudi...  -  Jul 23, 2008
The addition of adefovir dipivoxil to ongoing lamivudine therapy in patients with chronic HBV infection seems to be an effective salvage therapy in cases in ... Nature.com

Aurobindo Pharma gets US FDA nod for Lamivudine  -  Jun 16, 2005
Aurobindo Pharma [ Get Quote ] on Thursday said it had received US FDA approval for anti-retroviral Lamivudine, thus enabling it to participate in the ... Rediff

Age-dependent Pharmacokinetics of Lamivudine in HIV-infected Children  -  Oct 15, 2006
The recommended dose of lamivudine in children is higher when compared with adults: 4 mg/kg vs 2 mg/kg (150 mg) and administered twice a day. ... Nature.com

Nucleoside reverse transcriptase inhibitors (NRTIs) for chronic...  -  Oct 15, 2007
Lamivudine is approved for use by adults and by children ages 2 to 17. ... After 1 year of treatment with lamivudine, up to one-third of hepatitis B viruses ... WebMD

Is lamivudine a safe and effective therapy for patients with chronic ...  -  Jan 26, 2005
Liaw et al. (2004) Lamivudine for patients with chronic hepatitis B and advanced liver disease. N Engl J Med 351: 1521–1531 PubMed ... Nature.com

Long-term lamivudine therapy in hepatitis B-associated membranous …  -  Jan 18, 2006
Correspondence: YY Ng, Department of Medicine, Taipei Veterans General Hospital, Section of Nephrology, 201 Shih-pai rd, Shih-pai, Taipei, Taiwan. ... Nature.com

Safer, better medication for Hepatitis B identified  -  Jun 28, 2008
Lamivudine is one treatment for HBV, but the virus commonly becomes resistant and leads to disease progression. Adefovir dipivoxil is another treatment ... सिफी - सिफी

India's Ranbaxy has 3 more AIDS drugs on WHO list  -  Sep 10, 2007
The Ranbaxy anti-retroviral drugs added to the list are tablet combinations of lamivudine and zidovudine with a single tablet of efavirenz, and two tablet ... Reuters India

… with Interferon- and Lamivudine Combination Compared to Lamivudine...  -  Jan 29, 2005
Monotherapy with interferon (IFN) or lamivudine is effective in a limited ... To compare the efficacy of sequential lamivudine and IFN therapy versus ... Nature.com

India's Strides Arcolab gets FDA nod for two HIV/AIDS new drug …  -  Jun 6, 2007
The company said the approvals are for the combination of Lamivudine/Stavudine 150 mg/40 mg tablets and Lamivudine/Zidovudine 150/300 mg tablets, ... Forbes

Researchers find better HIV medication  -  Jan 19, 2006
The therapy was compared to the combination of zidovudine, lamivudine (AZT and 3TC ... However, those patients with no problems on the zidovudine-lamivudine ... 新�网

HK experts find telbivudine works better to suppress HBV  -  Jan 3, 2008
The studies included comparisons of the effectiveness between telbivudine and lamivudine, and that between telbivudine and adefovir. ... 新�网

FDA Approves New Hepatitis B Drug  -  Mar 30, 2005
Current treatment options for chronic hepatitis include interferon, given by injection, and two drugs administered orally, lamivudine and adefovir dipivoxil ... FOXNews

Combination Therapy for Chronic Hepatitis B: Simultaneous or Sequentia...  -  Sep 19, 2006
Sequential therapy with lamivudine followed by IFN- seems to have better ... First, combination of IFN- and lamivudine is given to patients at the same time ... Nature.com

Aurobindo gets FDA nod for AIDS drug  -  Sep 8, 2008
Aurobindo Pharma would manufacture and market Abacavir Sulfate/ Lamivudine tablets in the strengths of 600 mg and 300 mg, the filing said. ... सिफी - सिफी

Lamivudine-Resistant Hepatitis B Patients Achieve Sustained Benefits ...  -  Apr 17, 2007
By Jill Stein. BARCELONA, SPAIN -- April 17, 2007 -- Long-term treatment with adefovir dipivoxil and lamivudine decreases the risk of genotypical resistance ... DG News

Entecavir May Be Effective for Hepatitis B Refractory to Lamivudine  -  Jun 30, 2008
June 30, 2008 — Entecavir was effective in patients with chronic hepatitis B virus infection refractory to lamivudine therapy, according to the results of a ... Medscape

Lamivudine (Systemic).  -  Feb 1, 2006
Lamivudine (la-MI-vyoo-deen) is used in the treatment of the infection caused by the human immunodeficiency virus (HIV) or hepatitis B virus. ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Optimizing Management Strategies in Special Patient Populations  -  Jul 15, 2005
This has been accomplished with interferon and with lamivudine, ... Villenueve et al. showed that lamivudine effectively suppressed viral load ( 5 ). ... Nature.com

Pediatric AIDS pill approved  -  Aug 13, 2007
The generic pill made by India's Cipla Ltd combines the generic HIV-fighting drugs lamivudine, stavudine and nevirapine. This is the first pill of its kind ... Reuters

GLOBE study finds telbivudine superior to current standard of care on...  -  Nov 14, 2005
...-4.4 log10 with lamivudine; p0.01). Similarly, after 52 weeks of treatment, significantly more patients receiving telbivudine achieved clearance of ... Free with registration - Europe Intelligence Wire - AccessMyLibrary.com

… ) Demonstrated Benefits Over Lamivudine In Treating Chronically...  -  Mar 11, 2006
BARACLUDE Compared to Lamivudine for Treatment of Nucleoside-Naive, ... Treatment with both BARACLUDE and lamivudine resulted in reductions in fibrosis as ... Medical News Today - Medical News Today (press release)

Standard Hepatitis B Treatment Bested by Newcomer  -  Dec 19, 2007
Entecavir has also been shown to be more effective than lamivudine and creates less resistance as well. To learn more about available treatments for ... Washington Post

Alcoholic Liver Disease Treatment - Alcoholic Liver Disease Health …  -  Dec 12, 2008
Peginterferon is sometimes prescribed in combination with lamivudine ... Lamivudine and Entecavir. These two drugs are classified as nucleoside analogs. ... New York Times

China develops reagent for testing drug resistance of hepatitis B  -  Oct 11, 2005
Lamivudine is an effective and popular drug for treating hepatitis B, but there has been growing concern about the the tolerance of HBV to the drug. ... 新�网

… higher rates of improvement than lamivudine in patients with...  -  Jun 1, 2006
A phase 3 study evaluating the histologic and virologic improvement of hepatitis B antigen positive (HBeAg) patients randomized to either lamivudine or ... Free with registration - Formulary - AccessMyLibrary.com

Ranbaxy gets marketing nod for paediatric anti-retrovirals  -  Dec 7, 2007
While Coviro-LS kid is a combination of Lamivudine 20mg and Stavudine 5mg, ... Lamivudine is sold by GSK under the brand name Epivir and EPivir-HBV, ... Hindu Business Line

Hepatitis B  -  May 10, 2005
An alternative treatment is a drug called lamivudine which is taken orally once a day. ... Sometimes lamivudine is combined with interferon. BBC News

Lamivudine-Resistant Mutation Among Treatment-Naïve Hepatitis B …  -  Nov 7, 2008
By Arushi Sinha. SAN FRANCISCO -- November 7, 2008 -- Patients with hepatitis B virus (HBV) appear to have a high prevalence of lamivudine resistance ... DG News

FDA OKs 3-Drug Combo Pill to Treat HIV  -  Jun 30, 2006
The twice-daily pills combine three drugs already widely used to treat human immunodeficiency virus: lamivudine, zidovudine and nevirapine. ... FOXNews

ABACAVIR, LAMIVUDINE, AND ZIDOVUDINE (Oral route) - a-BAK-a-veer …  -  May 1, 2007
The three nucleoside analogue combination (abacavir sulfate/lamivudine/zidovudine) is intended only for patients whose regimen would otherwise include these ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Peginterferon Alpha-2a May Be Better Than Lamivudine in . . .  -  Jun 29, 2005
June 29, 2005 — Peginterferon α-2a is superior to lamivudine in the treatment of patients with e-Ag–positive hepatitis B virus (HBV), according to the ... Medscape

… Load Worsen on Fixed-Dose Abacavir/Lamivudine Compared With Fixed …  -  Aug 9, 2008
..."In the abacavir/lamivudine group there were 57 virologic failures," Dr. Sax said in an oral late-breaker presentation here on August 7. ... DG News

Mmegi Online ::> news we need to know  -  Jan 24, 2006
Since 1998, zidovudine and lamivudine have been available in a single-pill formulation called Combivir, which is prescribed as one pill taken twice daily. ... Mmegi Online

STRIDES ARCOLAB GETS TENTATIVE USFDA NOD FOR LAMIVUDINE …  -  Mar 6, 2007
MUMBAI, March 6 Asia Pulse - Drug maker Strides Arcolab Ltd (BSE:532531) on Monday said it has received tentative approval from the United States Food and ... Free with registration - AsiaPulse News - AccessMyLibrary.com

Novartis says Sebivo cleared in Switzerland for treating chronic...  -  Sep 21, 2006
The Swiss drugmaker said that Sebivo has shown to deliver more rapid and profound viral suppression than commonly used Lamivudine. ... Forbes

allAfrica.com: South Africa: Aspen Queries HIV Treatment Numbers  -  Feb 26, 2008
Saad said Aspen had used sales of lamivudine to gauge the size of the patient ... Aspen was awarded 80% of the contract to supply lamivudine to the state, ... AllAfrica.com

Ranbaxy receives okay for Lamivudine  -  May 29, 2005
New Delhi, May 28: Ranbaxy Laboratories Limited (RLL) announced on Saturday that it has received tentative approval from the US Food and Drug Administration ... Financial Express

Rwanda: Country to Override Copyrights on ARVs  -  Jul 22, 2007
Combivir, made by GlaxoSmithKline of Britain, contains lamivudine and zidovudine. Nevirapine is a generic version of Viramune, made by Boehringer Ingelheim ... AllAfrica.com

… to make HIV medicines indinavir sulfate 400, zidovudine 300, lamivu...  -  Aug 31, 2006
He said the HA would now manufacture indinavir sulfate 400, zidovudine 300 and lamivudine 300. He said the Centre has already granted the necessary ... Expressindia.com

Aurobindo gets USFDA nod for oral solution of AIDS drug  -  Nov 7, 2005
The tentative approval is for 10 mg/ml of oral solution of Lamivudine, ... It said Lamivudine oral solution of 10 mg/ml is the first generic version ... Hindu Business Line

Strides gets nod for 2 NDAs  -  Mar 15, 2007
The latest approvals are for fixed dose combination of lamivudine/ stavudine 150 mg/40 mg tablets; and lamivudine / stavudine 150/40 mg tablets co-packaged ... Hindu Business Line

Ranbaxy AIDS drugs back in WHO list  -  Aug 19, 2005
Two of the drugs contain combination of lamivudine and stavudine in ... Two of these are lamivudine tablets in different strengths and the third is ... Rediff

New drug cuts Hepatitis B deaths  -  Jan 4, 2008
It found that for patients who had just been infected, Telbivudine reduced the virus eight times more after one year than Lamivudine which is also an ... The Standard

Approach to the Hepatitis B Patient With Lamivudine Resistance  -  Dec 12, 2006
A patient with chronic hepatitis B has developed resistance to lamivudine. Is it reasonable to continue lamivudine in combination with a second antiviral ... Medscape

Pegylated Interferon-[Alpha]2b and Lamivudine in Hepatitis BE Antigen...  -  Sep 7, 2005
TO THE EDITOR: In Chan and colleagues' study of pegylated interferon in patients with hepatitis B e antigen (HBeAg)-positive chronic hepatitis B (1), ... RedOrbit

Apotex to make generic AIDS drug from patented formula - Canada first...  -  Oct 7, 2007
Rwanda had notified the WTO back in July that it would be buying 260000 packs of TriAvir - a fixed-dose combination product of Zidovudine, Lamivudine and ... Jamaica Gleaner

Lamivudine Curbs Hepatitis B Virus Reactivation in Liver Cancer  -  Feb 8, 2006
By Graciela Flores. NEW YORK FEB 08, 2006 (Reuters Health) - Preemptive use of lamivudine reduces overall hepatic morbidity and the severity of clinical ... Cancerpage.com

Rwanda: Clear the Air, Health Ministry  -  May 12, 2008
Apo-TriAvir combines Zidovudine, Lamivudine and Nevirapine, three drugs otherwise administered separately to patients. Apotex plans to dispatch pills to the ... AllAfrica.com

Lamivudine and Zidovudine combination tentatively approved by FDA/ …  -  Jul 9, 2005
The Food and Drug Administration within the US Department of Health and Human Services (HHS/FDA) today announced the tentative approval of the fixed-dose ... Medical News Today - Medical News Today (press release)

Idenix, Novartis seek approval for chronic hepatitis B treatment.  -  Jan 4, 2006
...the companies found greater suppression of the hepatitis B virus by telbivudine compared with a standard current therapy, lamivudine. ... Free with registration - Boston Globe - AccessMyLibrary.com

What is the more suitable for early detection of low abundant lamivudi...  -  Jan 16, 2008
Lamivudine is an effective antiviral agent for treatment of patients with chronic ... However, long-term lamivudine monotherapy leads to the emergence of ... eurekalert.org

… Demonstrates Advantages Over Lamivudine in HBeAg-positive Chronic ...  -  May 17, 2005
By Idenix Pharmaceuticals, Inc., Idenix Pharmaceuticals, Inc. today announced the presentation of interim two-year results from an extended-treatment phase ... RxPG NEWS

Bristol: Baraclude shows greater benefits than lamivudine.  -  Mar 8, 2006
SAN FRANCISCO (MarketWatch) -- Bristol-Myers Squibb Co. after Wednesday's closing bell said Baraclude demonstrated greater benefit in treating ... Free with registration - America's Intelligence Wire - AccessMyLibrary.com

AIDS drug prices to fall  -  Sep 24, 2006
While in case of another drug, Lamivudine 300 mg, RDPL is cheaper by Rs 65 than Cipla's price. Other PSUs such as Indian Drugs & Pharmaceuticals, ... Times of India

Telbivudine tops lamivudine for HBV at 2 years.(Gastroenterology)( …  -  Feb 15, 2007
BOSTON -- Telbivudine showed greater efficacy than lamivudine did during 2 years of treatment for chronic hepatitis B infection, according to the most ... $4.95 - Internal Medicine News - ECNext

Aurobindo's drug in WHO list  -  Dec 12, 2005
The other products included are Zidovudine tablets - 300 mg, Lamivudine tablets - 150 mg and Lamivudine tablets - 300 mg, it said. ... Rediff

Pegylated Interferon-2b and Lamivudine in Hepatitis B e Antigen...  -  Sep 6, 2005
We appreciate the interest and comments of Drs. ter Borg and Janssen. In our study, the proportion of patients who achieved HBeAg seroconversion at the end ... Annals of Internal Medicine

Tentative approval of co-packaged lamivudine/zidovudine fixed dose …  -  Jan 26, 2005
The Food and Drug Administration (FDA) has announced the tentative approval of a co-packaged antiretroviral drug regimen manufactured by Aspen Pharmacare of ... News-Medical.net

Lamivudine for Hepatitis B with Advanced Fibrosis  -  Feb 15, 2005
Clinical Question: Is lamivudine safe and effective for the treatment of hepatitis B infection in patients with advanced liver disease? ... AAFP News Now

The More Suitable For Early Detection Of Low Abundant Lamivudine- …  -  Jan 20, 2008
Lamivudine is an effective antiviral agent for treatment of patients with chronic ... However, long-term lamivudine monotherapy leads to the emergence of ... Medical News Today - Medical News Today (press release)

Abacavir and Lamivudine (Systemic ).  -  Jul 28, 2005
Abacavir (a-BAK-a-veer), and lamivudine ( la-MI-vyoo-deen) combination is used in the treatment of human immunodeficiency virus (HIV) infection. ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Ranbaxy to launch HIV drug combo in India  -  Nov 30, 2005
Virolis-E contains two fixed dose combination tablets of Lamivudine and Stavudine and one tablet of Efavirenz. Virocomb-E consists of two combination ... United Press International

US FDA tentative nod for Aurobindo tablets  -  Jul 13, 2005
HYDERABAD: Aurobindo Pharma has received tentative approval from the US Food and Drug Administration for lamivudine and zidovudine, 150 mg and 300 mg ... The Hindu

New Hepatitis B drug to be funded  -  Apr 6, 2006
Auckland Hospital heptologist Ed Gane says the existing drug, Lamivudine, has been an extremely effective treatment, but many patients requiring long-term ... TVNZ

Government to subsidise hepatitis drug  -  May 23, 2005
Dr Moodie said extending funding of lamivudine to people in that group would see about 200 additional people treated each year, at a total cost over five ... New Zealand Herald

Pegylated interferon superior to lamivudine for first line hepatitis...  -  Jul 4, 2005
Pegylated interferon is superior to lamivudine (3TC, Epivir) for first-line treatment of chronic hepatitis B virus (HBV) that is hepatitis B `e` ... Aidsmap

Avoid the tragedy of hepatitis B reactivation in immunosuppressed …  -  Oct 16, 2006
Prophylaxis for HBV reactivation with lamivudine has shown promising efficacy, ... To evaluate the use of lamivudine as the primary prophylaxis for HBV ... Nature.com

FDA approves first three-drug fixed-dose tablet for PEPFAR use  -  Jul 5, 2006
...“This new option, a fixed dose combination tablet containing lamivudine, ... The recommended regimen for the lamivudine-zidovudine-nevirapine tablet is one ... Aidsmap

Lamivudine is still useful against some hepatitis B.(Gastroenterology)...  -  Oct 1, 2006
Lamivudine is still useful against some hepatitis B.(Gastroenterology)(Clinical report) ... find Internal Medicine News articles. SOUTH LAKE TAHOE, CALIF. Pay-Per-View - Internal Medicine News - HighBeam Research

New Telbivudine Data From Three Clinical Trials to be Presented This ...  -  Oct 27, 2006
Lamivudine-treated patients achieved mean HBV DNA reductions of -4.4 log10 in ... In a study of patients previously treated with lamivudine, patients who ... Free with registration - PR Newswire - AccessMyLibrary.com

… ; Adefovir dipivoxil tackles all patterns of lamivudine-resistant...  -  Mar 26, 2005
Four major patterns of lamivudine-resistant HBV were identified: rtL180M + rtM204V (60%), rtV173L + rtL180M + rtM204V (19%), rtM204I (9%), and rtL180M + ... Pay-Per-View - Obesity, Fitness & Wellness Week - Factiva, from Dow Jones

SEBIVO® Demonstrated Better Antiviral Activity Compared to Adefovir...  -  Apr 13, 2007
Patients switched from lamivudine to telbivudine at six months(n=122) experienced an additional reduction of 1.90 log10 copies/mL compared to 0.90 log(10) ... EndoNurse

… Patients With Persistent Viraemia From Lamivudine to Telbivudine...  -  Nov 1, 2006
The trial enrolled patients who had received lamivudine for 3 to 12 months at the time of screening, who were hepatitis s antigen (HBsAg)-positive, ... DG News

Lamivudine is still useful against some hepatitis B.(Gastroenterology)...  -  Oct 1, 2006
SOUTH LAKE TAHOE, CALIF. -- Lamivudine and interferon alfa still have independent roles to play in treating some patients with chronic hepatitis B, ... Free with registration - Internal Medicine News - AccessMyLibrary.com

… Response on Antiviral Measures Than Lamivudine in Chronic Hepatitis...  -  May 24, 2006
...[Presentation title: Phase III Comparison of Telbivudine vs Lamivudine in Patients With Chronic Hepatitis B: Efficacy, Safety, and Predictors of Response at ... DG News

… Continues to Show Superior Efficacy over Lamivudine in Chronic HBV...  -  Dec 29, 2005
By Bonnie Darves. KOHALA COAST, HI -- December 29, 2005 -- The investigational polymerase inhibitor telbivudine continues to show strong antiviral activity ... DG News

Docs take anti-Aids drugs, but keep mum  -  Jan 11, 2005
A combination of anti-retro viral drugs Lamivudine and Zudovudine are taken twice a day. That is 60 tablets per month, says Dr MV Ramana Rao, joint director ... Times of India

Idenix Pharmaceuticals, Inc. Conference Call Discussing Abstracts …  -  Oct 3, 2005
In the e-antigen negative group, Telbivudine and Lamivudine performed similarly on both the ... Again, Telbivudine out performed Lamivudine for the direc. Free with registration - Fair Disclosure Wire - AccessMyLibrary.com

What is the optimal regimen for preventing hepatitis B recurrence...  -  Aug 13, 2008
HBIG was discontinued in patients with HBV recurrence and lamivudine was used as ... Patients transplanted after 2004 received lamivudine plus adefovir, ... Nature.com

New hepatitis B drug  -  Apr 30, 2006
...“Its side effect profile is similar to that of lamivudine (the current recommended medication). The most common side effects seen with both these drugs were ... Malaysia Star

Aurobindo Pharma gets USFDA nod for another ARV  -  Jun 22, 2005
Earlier, the company received approval for Lamivudine. APL said it is one among very few most vertically integrated companies to participate in PEPFAR ... Hindu Business Line

Aurobindo`s ARV gets USFDA nod  -  Jul 6, 2005
This is the fourth Anti-retroviral (ARV) Abbreviated New Drug Application approved by US FDA for the company after Nevirapine, Lamivudine and Efavirenz, ... Business Standard

HIV sufferers get combined pill  -  Dec 22, 2006
It contains two medicines already subsidised for people with HIV, abacavir and lamivudine. The Aids Foundation welcomed the change, but warned that ... New Zealand Herald

Strides gets WHO approval for HIV drug  -  Jul 4, 2006
Organization (WHO) has included its generic fixed dose combination of anti-HIV drug - Lamivudine Zidovidine - in the list of pre-qualified suppliers. ... Business Standard

Aurobindo receives tentative approval for lamivudine from US FDA  -  Jun 23, 2005
City-based pharma major Aurobindo Pharma has received tentative approval for its lamivudine tablets, a generic AIDS drug, from US FDA under the President's ... expresspharmapulse.com

AIDS drug prices to fall  -  Sep 25, 2006
While in case of another drug, Lamivudine 300 mg, RDPL is cheaper by Rs 65 than Cipla's price. Other PSUs such as Indian Drugs & Pharmaceuticals, ... Pay-Per-View - Times of India - Factiva, from Dow Jones

Lamivudine helps avoid Hepatitis B relapse during chemotherapy  -  Feb 12, 2006
A new study on treating hepatitis B patients who have cancer with an antiviral drug at the same time as they undergo chemotherapy found that the treatment ... News-Medical.net

Virology; Molecular beacons quantify lamivudine-resistant hepatitis B...  -  Apr 12, 2005
..."A real-time based amplification assay with molecular beacons was used to detect and quantify polymerase chain reaction (PCR) amplicons to discriminate ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

… Successfully Achieved In Phase II Clinical Trial Of ANA380 In...  -  Feb 15, 2006
Genetically-altered HBV that is resistant to lamivudine can be detected in 14 to 32 percent of patients after one year of lamivudine treatment and in more ... Medical News Today - Medical News Today (press release)

Study: Roche drug better at controlling hepatitis  -  Jun 30, 2005
Lau and his team at Queen Mary Hospital in Hong Kong found Pegasys suppressed the virus better than British company GlaxoSmithKline's drug lamivudine. ... Pay-Per-View - Star-Ledger - Factiva, from Dow Jones

… of Rotterdam; Molecular beacons quantify lamivudine-resistant...  -  Apr 13, 2005
Pas and colleagues published their study in the Journal of Clinical Virology (Quantification of the newly detected lamivudine resistant YSDD variants of ... Pay-Per-View - Biotech Week - Factiva, from Dow Jones

Abacavir sulfate and lamivudine tablets (Epzicom).(Pharmocology...  -  Jan 1, 2005
THE FDA HAS APPROVED A COMBINATION OF 2 ANTIretrovirals, abacavix and lamivudine, for the treatment of HIV-1 infections. Each tablet contains 600 mg of ... Pay-Per-View - Infectious Disease Alert - Factiva, from Dow Jones

Oxxon Therapeutics Reports Positive Preliminary Phase IIa Data With …  -  Nov 11, 2005
In addition, no patient receiving lamivudine had seroconverted by week 14 whereas 5/40 (13%) of patients having received immunotherapeutic alone had done so ... RedOrbit

… Data Disputed in Abacavir/Lamivudine Comparison Trial: Presented...  -  Aug 10, 2008
By Ed Susman. MEXICO CITY -- August 10, 2008 -- A pooled analysis of 6 clinical trials did not uncover any evidence that the fixed-dose combination of ... DG News

Ranbaxy Receives Tentative Approval for Lamivudine Tablets as Part of...  -  May 27, 2005
PRINCETON, NJ, May 27 /PRNewswire/ -- Ranbaxy Laboratories Limited (RLL) announced today that it has received tentative approval from the US Food and Drug ... $4.95 - PR Newswire - ECNext

May 2005: Anti-infective Agents  -  Mar 29, 2005
The safety profiles of entecavir and lamivudine were comparable in these studies. ... The most common adverse events among lamivudine-treated patients were ... Medscape

Brand Names/Synonyms:
Lamivudine is also known by the following brand names and/or synonyms3TC; Combivir; DRG-0126; Epivir; Epivir-Hbv; GR 109714X; HSDB 7155; Hepitec; Heptovir; LAMIVUDINE; Lamivudine; Lamivudine [Usan:Ban:Inn]; Trizivir; Zeffix

Drug Category:
Lamivudine is categorized under the following by the FDA: Anti-HIV Agents; Nucleoside and Nucleotide Reverse Transcriptase Inhibitors; ATC:J05AF05

Dosage Forms:
SOLUTION; TABLET

Absorption:
Lamivudine was rapidly absorbed after oral administration in HIV-infected patients. Absolute bioavailability in adults is 86% ± 16% for the tablet and 87% ± 13% for the oral solution.

Interactions:
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Chemical IUPAC Name:
4-amino-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-1H-pyrimidin-2-one





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