Lamotrigine

This page contains recent news articles, when available, and an overview of Lamotrigine but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Lamotrigine
(when available)

Pharmacology and use:
Lamotrigine, an antiepileptic drug (AED) of the phenyltriazine class, is chemically unrelated to existing antiepileptic drugs. Lamotrigine is also used in the treatment of depression and bipolar disorder. Lamotrigine is thought to exert its anticonvulsant effect by stabilizing presynaptic neuronal membranes. Lamotrigine inhibits sodium currents by selectively binding to the inactivated state of the sodium channel and subsequently suppresses the release of the excilatory amino acid, glutamate. For the adjunctive treatment of partial seizures in epilepsy and generalized seizures of Lennox-Gastaut syndrome; For the maintenance treatment of Bipolar I Disorder

Mechanism Of Action:
One proposed mechanism of action of Lamotrigine, the relevance of which remains to be established in humans, involves an effect on sodium channels. in vitro pharmacological studies suggest that lamotrigine inhibits voltage-sensitive sodium channels, thereby stabilizing neuronal membranes and consequently modulating presynaptic transmitter release of excitatory amino acids (e.g., glutamate and aspartate).

News Articles on Lamotrigine

Extended-Release Lamotrigine Monotherapy Effective, May Be Accompanied by ...  -  ‎Dec 10, 2009‎
BOSTON -- December 10, 2009 -- Lamotrigine appears to be tolerable in a new extended-release form, according to research presented here at ... DG News

Antiepileptic Medications May Be Risk Factors for Premenstrual Dysphoria ...  -  ‎Dec 10, 2009‎
Risk factors include the affected region of the brain and carbamazepine usage, while certain hormonal ratios and use of lamotrigine were inversely related ... DG News

Vigabatrin (Sabril®): A New Epilepsy Drug -- With Strings Attached  -  ‎Dec 31, 2009‎
...gabapentin (Neurontin®), lacosamide (Vimpat®), lamotrigine (Lamictal®), levetiracetam (Keppra®), oxcarbazepine (Trileptal®), pregabalin (Lyrica®), ... Medscape

Pharmacotherapy for borderline personality disorder: Cochrane systematic ...  -  ‎Dec 31, 2009‎
Most beneficial effects were found for the mood stabilisers topiramate, lamotrigine and valproate semisodium, and the second-generation antipsychotics ... British Journal of Psychiatry

Cambridge Scientists Archive 500000th Crystal Structure  -  ‎Dec 10, 2009‎
The CSD's 500000th structure is the anti-convulsant drug Lamotrigine (Lamictal(R)) which was discovered by GlaxoSmithKline and approved by the US FDA for ... PR Newswire (press release)

New STEDESA™ Clinical Data Presented at American Epilepsy Society Annual ...  -  ‎Dec 10, 2009‎
When analyzed by subgroup, the incidence of hyponatremic TEAEs was more pronounced for patients administered ESL plus carbamazepine (CBZ), lamotrigine (LTG) ... Centre Daily Times

Cross-breeding leading to native livestock decline in Orissa  -  ‎Dec 13, 2009‎
Erythromycin, Fluconazole, Fluoxetine, Indometacin, Ketoconozole, Lamotrigine, Loratadine, Nitrofurantoin, Nizatidine, Omeprazole, Oxytetracycline, ... TopNews

Aurobindo Pharma receives final approval for Lamotrigine Tablets from USFDA  -  ‎Nov 13, 2009‎
Aurobindo Pharma Limited is pleased to announce that it has received the final approval for Lamotrigine Tablets (Chewable, Dispersible) 5mg and 25mg from ... Equity Bulls

Aurobindo Pharma Receives Final Approval From US FDA For Lamotrigine Tablets  -  ‎Nov 5, 2009‎
...(RTTNews) - Aurobindo Pharma said that it received final approval from US FDA for Lamotrigine tablets (chewable, dispersible) of 5 mg and 25 mg strengths. ... RTT News

Aurobindo Pharma gets nod for Lamotrigine Tablets  -  ‎Nov 6, 2009‎
Aurobindo Pharma has informed that it has secured nod from the US Food & Drug Administration (USFDA) for its chewable and dispersible Lamotrigine tablets in ... TopNews

Aurobindo Pharma pares early losses on US nod for generic drug  -  ‎Nov 11, 2009‎
Late last week, Aurobindo Pharma had received approval from US FDA for Lamotrigine tablets in 5 miligram and 25 miligram strengths. Lamotrigine tablet is ... India Infoline.com

Corporate notes  -  ‎Nov 6, 2009‎
Pharma firm Aurobindo Pharma on Friday said it has received final approval for from the US health regulator for lamotrigine tablets used to treat epilepsy. ... Financial Express

Aurobindo Pharma gets USFDA nod for epilepsy drug  -  ‎Nov 5, 2009‎
Drug maker, Aurobindo Pharma has received the final approval from the US Food and Drug Administration (USFDA) to market Lamotrigine tablets on prescription ... Myiris.com

New systematic study for managing treatment-resistant bipolar depression  -  ‎Oct 27, 2009‎
Previous treatments for past episodes that had been tried included lamotrigine plus lithium, mood stabilizers plus multiple antidepressants, ... News-Medical.net

Contracts, Etc.  -  ‎Nov 12, 2009‎
Cadista Pharmaceuticals of Salisbury won $3.99 million from the Department of Veterans Affairs for lamotrigine tablets. Dave Wheatley Enterprises of ... Business Gazette

Eurand Reports Key Achievements and Strong Revenue Growth for Third Quarter 2009  -  ‎Nov 5, 2009‎
...approved by the FDA since 2001 and the second this year following the May 8th approval of LAMICTAL® ODT(TM) (lamotrigine) Orally Disintegrating Tablets. ... CNNMoney.com (press release)

Federal Contracts Awarded to Companies in Maryland (Nov. 7)  -  ‎Nov 7, 2009‎
Md., won a $3992372 federal contract from the US Department of Veterans Affairs National Acquisition Center, Hines, Ill., for Lamotrigine tablets. ... Targeted News Service (subscription)

Dr Reddy's seeks US marketing rights for `Lipitor' generic  -  ‎Nov 7, 2009‎
Ramipril (Altace - King), Venlafaxine (Effexor -Wyeth), Lamotrigine (Lamictal - Glaxo Smith Kline), and Levetiracetam (Keppra - UCB). ... domain-B

India Controlled NMDC, MMTC Soar  -  ‎Nov 6, 2009‎
...said Friday it has received the final approval from the US Food and Drug Administration for selling a generic version of the epilepsy drug, lamotrigine. ... 123Jump.com

Sensex holds on to early gains  -  ‎Nov 5, 2009‎
Aurobindo Pharma receives USFDA nod for Lamotrigine Tablets. Shares of Aurobindo Pharma have surged by over 3.5% to Rs833. The stock opened at Rs810 and ... India Infoline.com

BREAKING NEWS: Relenza helps GSK return to sales growth  -  ‎Oct 28, 2009‎
Generic competition across the Atlantic again tore into sales of Lamictal (lamotrigine), which fell 21% to £121 million and Imigran/Imitrex (sumatriptan), ... Pharma Times

Bipolar II Postpartum Depression: Detection, Diagnosis, and Treatment  -  ‎Nov 2, 2009‎
Lamotrigine should be used cautiously because of concerns about skin rash and higher-than-expected drug levels in the infant after exposure through ... Am J Psychiatry (subscription)

Pharmaceutical Journal - Avoid folic acid antagonists in first trimester of ...  -  ‎Oct 20, 2009‎
...phenytoin, lamotrigine, primidone and colestyramine, were taken by 179 women. Folic acid antagonists associated with increased risk of defects Overall, ... DeHavilland (press release) (subscription)

Contraception, contragestion et épilepsie  -  ‎Oct 27, 2009‎
Inversement, les pilules estroprogestatives diminuent la biodisponibilité de la lamotrigine en accélérant son élimination. Les neurologues doivent tenir ... John Libbey Eurotext

Stevens-johnson syndrome  -  ‎Oct 23, 2009‎
...barbiturates, sulfonamides, phenytoin, azithromycin, modafinil[3], lamotrigine, nevirapine, ibuprofen[4], ethosuximide, carbamazepine)a tiez NSAID radu. ... Zdravie.sk

What's the evidence for lamotrigine?  -  Dec 4, 2008
We don't know for certain which epilepsy drugs work best, or if they all work about the same. But there is reasonably good evidence that taking lamotrigine ... guardian.co.uk

Lamotrigine May Reduce Epilepsy Seizures  -  Oct 15, 2007
By Robert Preidt. TUESDAY, Oct. 16 (HealthDay News) -- When taken once a day as an added therapy, the epilepsy drug lamotrigine is effective in controlling ... ABC News

Does lamotrigine alleviate the pain in diabetic neuropathy?  -  Apr 13, 2007
Vinik AI et al. (2007) Lamotrigine for treatment of pain associated with diabetic neuropathy: results of two randomized, double-blind, placebo-controlled ... Nature.com

Does adjunctive lamotrigine provide improved control of primary …  -  Dec 16, 2006
Trevathan E et al. (2006) Lamotrigine adjunctive therapy among children and adolescents with primary generalized tonic-clonic seizures. ... Nature.com

… of Pharmacokinetic Interaction between Oxcarbazepine and Lamotrigin...  -  Jul 27, 2005
At steady state, lamotrigine AUC (0–24) and C max were not significantly ... In conclusion, the combination of lamotrigine and oxcarbazepine does not ... Nature.com

Lamotrigine for epilepsy  -  Oct 29, 2007
Lamotrigine is used to treat a broad range of seizures. It helps control partial seizures, especially partial seizures with secondary generalization. ... WebMD

Epilepsy Drug May Raise Autism Risk in Offspring  -  Dec 2, 2008
Four of the children were exposed to valproate, one to valproate plus lamotrigine, one to phenytoid (Dilantin among other brand names) and one to ... Forbes

Phenytoin may cause bone loss in young women  -  Apr 28, 2008
The goal of the present study was to examine the impact that phenytoin, carbamazepine, lamotrigine and valproate had on actual bone loss. ... Reuters UK

THE NATION; Study Ties Epilepsy Drug to Fetal Risk  -  Aug 8, 2006
The rate for lamotrigine (Lamictal), was 1% -- one of 98 women on the drug. One in five women who took the widely used epilepsy drug valproate in a clinical ... Pay-Per-View - Los Angeles Times - ProQuest Archiver

Lamotrigine concentrations may be changed by commonly used …  -  Dec 1, 2005
Initially introduced as an antiepileptic agent, lamotrigine (Lamictal) is increasingly used for the management of psychiatric disorders, ... Free with registration - Brown University Psychopharmacology... - AccessMyLibrary.com

Mylan wins tentative US OK for generic Lamictal  -  Dec 12, 2007
Lamotrigine tablets are a generic version of GlaxoSmithKline's Lamictal tablets, which had US sales of $1.97 million (963913 pounds) for the 12 months ended ... Reuters UK

Mitigating Cutaneous Side Effects of Lamotrigine  -  Dec 18, 2005
By Antai-Otong, Deborah. Question: I plan to start one of my patients on lamotrigine because she has been a poor responder to previous pharmacologie ... RedOrbit

Lamotrigine-induced erythema multiforme mimicking contact dermatitis.(...  -  Jan 1, 2006
Erythema multiforme is an acute, hypersensitivity reaction of the skin often secondary to medications. Lamotrigine is a relatively new anticonvulsant ... Free with registration - Journal of Drugs in Dermatology - AccessMyLibrary.com

Fears over child epilepsy drugs  -  Jun 10, 2007
Professor Wong and his colleagues found three drugs in particular - lamotrigine, topiramate and levetiracetam - had seen a "massive" rise in prescribing. ... BBC News

Lopinavir/ritonavir reduces lamotrigine plasma concentrations in...  -  Feb 14, 2006
Manon J. van der Lee, PharmD 1 , Lara Dawood 1 , Hadewych JM ter Hofstede, MD 1 , Marga JA de Graaff-Teulen 1 , Eleonora WJ van Ewijk-Beneken Kolmer 1 ... Nature.com

Caraco gets tentative FDA OK for generic of GSK's Lamictal  -  Nov 12, 2007
...(Reuters) - Caraco Pharmaceutical Laboratories Ltd said it received tentative approval from US health regulators for its Lamotrigine tablets, ... Reuters

… Canada Endorsed Important Safety Information on Lamictal (Lamotrigi...  -  Aug 8, 2006
New data from a pregnancy registry suggest an association between taking Lamictal® (lamotrigine) in the first trimester of pregnancy, and increased risk of ... DG News

Adjunctive Lamotrigine Decreases Primary Generalized Tonic-Clonic …  -  Dec 9, 2005
By Fran Lowry. WASHINGTON, DC -- December 9, 2005 -- Adjunctive lamotrigine effectively controls primary generalized tonic-clonic seizures (PGTCS) and is ... DG News

FDA clears way for some generic Lamictal versions  -  Mar 2, 2007
Lamictal, or lamotrigine, is approved to help treat partial seizures in adults and children as well as bipolar disorder in certain patients. ... Reuters

Taro Receives Tentative FDA Approval For Lamotrigine Tablets ANDA  -  Apr 7, 2008
Taro Pharmaceutical Industries Ltd. ("Taro," the "Company," Pink Sheets: TAROF) reported today that it has received tentative approval from the US Food and ... Medical News Today - Medical News Today (press release)

Rash associated with lamotrigine and carbamazepine interaction.(Case ...  -  May 1, 2005
Comment: A 63-year-old man under treatment with lamotrigine and nefazodone for bipolar I disorder, and clonazepam for restless leg syndrome, presented with ... Free with registration - Brown University Geriatric Psychopharmac... - AccessMyLibrary.com

… effectiveness of LAMICTAL (lamotrigine) as adjunctive therapy  -  Aug 1, 2006
RESEARCH TRIANGLE PARK, NC, August 1, 2006 – Data published in today's issue of Pediatrics show that lamotrigine (LAMICTAL) is an effective add-on therapy ... eurekalert.org

Taro Receives Tentative FDA Approval for Lamotrigine Tablets ANDA  -  Apr 3, 2008
Taro Pharmaceutical Industries Ltd. ("Taro," the "Company," Pink Sheets: TAROF) reported today that it has received tentative approval from the US Food and ... Genetic Engineering News - Genetic Engineering News (press release)

Lamotrigine May Reduce Epilepsy Seizures  -  Oct 16, 2007
TUESDAY, Oct. 16 (HealthDay News) -- When taken once a day as an added therapy, the epilepsy drug lamotrigine is effective in controlling partial seizures, ... DentalPlans.com

Lamotrigine as a possible cause of QRS prolongation in a patient with...  -  Sep 1, 2006
Lamotrigine and felbamate are 2 newer anticonvulsant medications used to control refractory partial and generalized seizures. Although several cases of ... Free with registration - Canadian Journal of Emergency Medicine - AccessMyLibrary.com

Mitigating cutaneous side effects of lamotrigine.(The Art of Prescribi...  -  Oct 1, 2005
Question: I plan to start one of my patients on lamotrigine because she has been a poor responder to previous pharmacologic treatment. ... $4.95 - Perspectives in Psychiatric Care - ECNext

Pregnant Women on Lamotrigine Have Greater Risk of Seizures When …  -  Dec 7, 2006
By Paula Moyer. SAN DIEGO, CA -- December 7, 2006 -- Women with epilepsy who are treated with lamotrigine (Lamictal) during pregnancy and have low ... DG News

… Gains Greater with Valproate than with Lamotrigine in Epileptic...  -  Dec 8, 2005
To assess body weight and serum levels during the first year of treatment with either lamotrigine or valproate in adolescent and adult women, Dr. Hayes and ... DG News

Drug Choices for Different Seizures Get Clarification  -  Mar 23, 2007
For time to 12-month remission from seizures, lamotrigine was found non-inferior to ... For time to treatment failure, lamotrigine was significantly more ... MedPage Today

Short-lasting unilateral neuralgiform headache with conjunctival...  -  Jan 1, 2008
Available literature suggests that it responds to anticonvulsants, particularly lamotrigine. However, management of partial responders is difficult and ... Free with registration - Neurology India - AccessMyLibrary.com

Psychiatric Times.  -  Aug 1, 2006
Conducted over 7 weeks, the study randomized patients to lamotrigine 50 mg/d ... Response rates for patients treated with both dosages of lamotrigine were ... Psychiatric Times

Lamotrigine associated with neutropenia.(Case Report)(Brief Article)  -  Jul 1, 2005
Comment: A 23-year-old woman was hospitalized for treatment of bipolar II disorder, depressed phase. Comorbid diagnoses included polysubstance abuse and an ... Free with registration - Brown University Psychopharmacology... - AccessMyLibrary.com

… Seizure Freedom Than Topiramate or Lamotrigine: Presented at AES  -  Dec 4, 2007
73% more epilepsy patients are seizure free compared with patients on lamotrigine and 54% more compared with patients on topiramate, according to ... DG News

Analysts remain optimistic on Teva  -  Feb 18, 2005
Teva also announced Thursday that it has settled a patent litigation with GlaxoSmithKline (GSK) relating to lamotrigine, the generic version of ... Pay-Per-View - Jerusalem Post - ProQuest Archiver

Lamotrigine + valproate linked to birth defects.(Women's Health)  -  May 15, 2006
WASHINGTON -- There is no evidence that lamotrigine monotherapy increases the risk of major congenital malformations in infants exposed prenatally to the ... Free with registration - Internal Medicine News - AccessMyLibrary.com

Lamotrigine may improve pelvic pain, depression.(Pain Medicine) |...  -  May 1, 2008
Lamotrigine may improve pelvic pain, depression.(Pain Medicine) ... find Clinical Psychiatry News articles. BALTIMORE -- The anticonvulsant lamotrigine ... Pay-Per-View - Clinical Psychiatry News - HighBeam Research

Lamotrigine, Valproate Effective as First-Line Treatments of Various.....  -  Mar 27, 2007
March 27, 2007 — New research suggests lamotrigine should replace carbamazepine as first-line therapy for patients with partial epilepsy, and valproate ... Medscape

… ; Dosing algorithm facilitates conversion from valproate to lamotrig...  -  Apr 13, 2005
..."Among the 67 patients with at least one lamotrigine trough serum concentration after ... "By employment of a four-step dosing algorithm, lamotrigine serum ... Pay-Per-View - Biotech Week - Factiva, from Dow Jones

Use of Epilepsy Drug During Pregnancy May Increase Children's Autism ...  -  Dec 1, 2008
...(There was one case of autism each in children exposed to lamotrigine, phenytoin, and a combination of lamotrigine and valproate.) ... Health.com

Lamotrigine Improves Depressed Mood in Women With Epilepsy: …  -  May 11, 2006
By Maggie Schwarz. WASHINGTON, DC -- May 11, 2006 -- Depressed mood in patients with epilepsy can be improved with addition of lamotrigine to background ... DG News

… ; Dosing algorithm facilitates conversion from valproate to lamotrig...  -  Apr 11, 2005
..."Among the 67 patients with at least one lamotrigine trough serum concentration after ... "By employment of a four-step dosing algorithm, lamotrigine serum ... Pay-Per-View - Pain & Central Nervous System Week - Factiva, from Dow Jones

Lamotrigine Intoxication Provoking Status Epilepticus in an Adult...  -  Apr 5, 2007
Background Various anticonvulsant medications have been associated with paradoxical aggravation of epileptic seizures in therapeutic doses and toxic ... Archives of Neurology

Study: Symbyax Significantly Improves Bipolar Depression  -  May 22, 2006
Lamotrigine was titrated from 25 mg/day to 200 mg/day by the beginning of week six; ... Patients treated with Symbyax vs. lamotrigine had -1.70 and -1.46 ... insideindianabusiness.com

… ; Dosing algorithm facilitates conversion from valproate to lamotrig...  -  Apr 16, 2005
..."Among the 67 patients with at least one lamotrigine trough serum concentration after ... "By employment of a four-step dosing algorithm, lamotrigine serum ... Pay-Per-View - Obesity, Fitness & Wellness Week - Factiva, from Dow Jones

Interaction with other medicines  -  Feb 5, 2008
The combined oral contraceptive (COC) pill can speed up how quickly the liver breaks down lamotrigine. This reduces the amount of lamotrigine in the blood, ... NHS Choices

Clinical news: Clarification on first choice for epilepsy.(lamotrigine...  -  Mar 31, 2007
Lamotrigine should be the drug of first choice for patients with partial epilepsy, ... Lamotrigine emerged as significantly better for time to treatment ... $4.95 - Chemist & Druggist - ECNext

First Head-to-Head Study Suggests Significantly Greater Symptom …  -  May 30, 2006
Lamotrigine was titrated from 25 mg/day to 200 mg/day by the beginning of week six; ... Patients treated with Symbyax vs. lamotrigine had -1.70 and -1.46 ... DG News

Valproate Taken During Pregnancy May Increase Risk of Fetal …  -  Mar 21, 2005
A third study suggests that lamotrigine is not associated with these risks, ... "Even though the number of women enrolled in [the lamotrigine registry] was ... Medscape

First-trimester lamotrigine use tied to oral clefts.(Women's Health)(B...  -  Sep 1, 2008
First-trimester lamotrigine use tied to oral clefts.(Women's Health)(Brief article) ... find Family Practice News articles. MONTEREY, CALIF. Pay-Per-View - Family Practice News - HighBeam Research

Study Suggests Lamotrigine Is Drug of Choice for Epilepsy It is a...  -  Mar 23, 2007
FRIDAY, March 23 (HealthDay News) -- Lamotrigine is a better, cost-effective alternative to the standard drug treatment for partial-onset epilepsy, ... ModernMedicine

An open-label study of lamotrigine adjunct or monotherapy for the …  -  Mar 1, 2006
Objective: The treatment of pediatric bipolar depression has not been well studied. The authors wished to prospectively study the efficacy of lamotrigine as ... Pay-Per-View - Journal of the American Academy of... - Factiva, from Dow Jones

… (www.tevapharm. com) offers lamotrigine tablets, which are AB...  -  Sep 15, 2008
The lamotrigine tablets are available in 25-mg and 100-mg strengths, in bottle sizes of 100, and in 150 mg and 200 mg strengths, in bottle sizes of 60 ... $9.94 - Drug Topics - Alacra Store

Lamotrigine, gabapentin both relieve HIV neuropathy pain.(Infectious ...  -  Jul 1, 2005
OAKLAND, CALIF. -- Two anticonvulsants are competing in popularity for treating peripheral neuropathy in patients with HIV infection: gabapentin and ... Free with registration - Internal Medicine News - AccessMyLibrary.com

… Register 2007 - 72 FR 9763 Determination That LAMICTAL (Lamotrigine...  -  Mar 5, 2007
LAMICTAL (lamotrigine) tablets, 50 mg and 250 mg, are the subject of approved ... LAMICTAL (lamotrigine) is an antiepileptic drug indicated as adjunctive ... Pay-Per-View - Federal Register 2007 - Loislaw

Lamotrigine Does Not Cause Weight Gain in Bipolar Patients: Presented...  -  May 25, 2006
By Danny Kucharsky. TORONTO, CANADA -- May 25, 2006 -- Lamotrigine is not associated with a significant mean increase in weight or body mass index (BMI) ... DG News

Hair loss with lamotrigine.(Case Report)(Brief article)  -  Jan 1, 2007
During hospitalization for a depressive episode from a previously diagnosed bipolar disorder, a 63-year-old woman was started on lamotrigine therapy. ... Free with registration - Brown University Psychopharmacology... - AccessMyLibrary.com

Lamotrigine, valproate emerge as superior epilepsy treatment options...  -  Aug 1, 2007
The results of the Standard and New Antiepileptic Drugs (SANAD) trial, an unblinded, randomized, controlled, 2-arm study comparing the efficacy of various ... $4.95 - Formulary - ECNext

Monitoring of a Common Epilepsy Drug During Pregnancy Reduces …  -  Nov 28, 2007
For the study, 53 women taking lamotrigine underwent therapeutic drug ... In the current study, the clearance of lamotrigine increased by 89 percent in the ... HealthNewsDigest.com

… Skin Reaction Predict Rash in Paediatric Patients Receiving Lamotri...  -  Dec 7, 2008
A total of 21 children developed adverse skin reactions to lamotrigine, consisting of ... The other 5 children had received lamotrigine as monotherapy. ... DG News

Physician notes error on bipolar medication's ugly side effect  -  Jul 13, 2005
Studies done with lamotrigine in epilepsy and bipolar disorder suggest that the risk of Stevens-Johnson is less than 1/1000 (Calabrese et al., ... $2.95 - San Antonio Express-News - NewsBank

Lamotrigine, lithium effective--for a while.(Adult Psychiatry)(for...  -  Jul 1, 2007
PITTSBURGH -- Lamotrigine and lithium perform similarly well in preventing depressive or manic episodes in patients with bipolar disorder, but neither drug ... $4.95 - Clinical Psychiatry News - ECNext

First-trimester lamotrigine use tied to defects.(Brief article)  -  Nov 1, 2006
Use of the anticonvulsant lamotrigine during the first trimester of pregnancy may increase the likelihood of fetal development of cleft palate and lip, ... Free with registration - Clinical Psychiatry News - AccessMyLibrary.com

First-Trimester Exposure to Lamictal May Cause Oral Cleft  -  Sep 29, 2006
Also, a comparison of the risk associated with lamotrigine cannot be compared with ... Lamotrigine is indicated as adjunctive therapy for partial seizures, ... Medscape

First-trimester lamotrigine use may cause oral clefts.(Women's Health)  -  Oct 15, 2006
After several years of little indication that lamotrigine was linked to specific birth defects, a major pregnancy registry has found a significant increase ... $4.95 - Internal Medicine News - ECNext

Lamotrigine-birth defect link seen only in valproate combo.(Obstetrics...  -  Feb 15, 2006
Lamotrigine-birth defect link seen only in valproate combo.(Obstetrics) ... find OB GYN News articles. WASHINGTON -- There is no evidence that lamotrigine ... Pay-Per-View - OB GYN News - HighBeam Research

Once-a-Day Epilepsy Drug Is Effective for Partial Seizures  -  Oct 9, 2007
Newswise — The epilepsy drug lamotrigine is effective in controlling partial ... They received either lamotrigine in an extended-release formula or placebo ... newswise.com

Solo lamotrigine not linked to birth defects.(dosages during pregnanci...  -  Mar 1, 2006
Solo lamotrigine not linked to birth defects.(dosages during pregnancies)(Statistical data) ... find Clinical Psychiatry News articles. Pay-Per-View - Clinical Psychiatry News - HighBeam Research

… Kung University; HPLC determines lamotrigine concentration in...  -  Apr 27, 2005
According to researchers in Taiwan, "Lamotrigine is a broad-spectrum ... "Lamotrigine and the internal standard guanabenz were extracted with 1.2 ml of ... Pay-Per-View - Biotech Week - Factiva, from Dow Jones

New Study Weighs Benefits of Epilepsy Drugs  -  Mar 22, 2007
And lamotrigine should be the first choice for treating partial epilepsy, ... The researchers found that lamotrigine was significantly better for time to ... Washington Post

Lamotrigine goes off label for bipolar depression: most of the...  -  May 1, 2005
Lamotrigine goes off label for bipolar depression: most of the several hundred psychiatrists in the audience had prescribed the drug for bipolar disorder. Pay-Per-View - Internal Medicine News - HighBeam Research

Lamotrigine: dosing tips and prescribing pearls.(Tips and Pearls)  -  Jun 1, 2005
Lamotrigine is a first-line treatment for bipolar maintenance and bipolar depression ... Valproate inhibits lamotrigine metabolism, so when used together, ... Pay-Per-View - Clinical Psychiatry News - Factiva, from Dow Jones

Chromatography; HPLC determines lamotrigine concentration in small …  -  Apr 30, 2005
According to researchers in Taiwan, "Lamotrigine is a broad-spectrum antiepileptic agent. This study describes a simple and sensitive high-performance ... Pay-Per-View - Obesity, Fitness & Wellness Week - Factiva, from Dow Jones

Lamotrigine exposure linked to oral clefts.(Obstetrics) | Article...  -  Jul 15, 2006
Lamotrigine exposure linked to oral clefts.(Obstetrics) ... find OB GYN News articles. After several years of little indication that lamotrigine was linked ... Pay-Per-View - OB GYN News - HighBeam Research

Lamotrigine vs. citalopram for bipolar depression.(News Notes)(Clinica...  -  Jan 1, 2007
Their investigation compares 12-weeks of adjunctive lamotrigine (Lamictal) with adjunctive citalopram (Celexa) treatment in twenty patients already ... Free with registration - Brown University Psychopharmacology... - AccessMyLibrary.com

… Effectiveness of LAMICTAL(R) (Lamotrigine) As Adjunctive Therapy...  -  Aug 1, 2006
New Data Demonstrate Effectiveness of LAMICTAL(R) (Lamotrigine) As Adjunctive Therapy for Children and Adolescents With Primary Generalized Tonic-Clonic ... Pay-Per-View - PR Newswire - HighBeam Research

Are the first-line recommendations for antiepileptic drug therapy...  -  May 14, 2007
Lamotrigine was significantly better in terms of time to treatment failure than ... In a per protocol analysis of time to 1-year remission, lamotrigine was ... Nature.com

Lamotrigine and oral clefts.(DRUGS, PREGNANCY, AND LACTATION)  -  Dec 15, 2006
Historically, lithium has been a mainstay of treatment for bipolar disorder. However, over the last decade, anticonvulsant drugs such as sodium valproate ... $4.95 - Internal Medicine News - ECNext

… Tentative FDA Approval for Lamotrigine Tablets. - PR Newswire | …  -  Dec 12, 2007
Mylan Announces Tentative FDA Approval for Lamotrigine Tablets. from PR Newswire. Highbeam Research – FREE Trial. Pay-Per-View - PR Newswire - HighBeam Research

Data help prioritize drugs for treating epilepsy.(Clinical Rounds) |...  -  Apr 15, 2007
Patients taking lamotrigine had significantly longer time to treatment ... Lamotrigine had an advantage over oxcarbazepine, but it was not significant. ... Pay-Per-View - Family Practice News - HighBeam Research

New Studies Help Patients With Treatment-Resistant Bipolar Disorder  -  Feb 1, 2006
Lamotrigine is an antiseizure medication; many such medications have effectiveness in bipolar disorder. Inositol affects hormone signaling inside nerve ... Medical News Today - Medical News Today (press release)

Mum's epilepsy med linked to low IQ in kids  -  May 15, 2007
In an ongoing study, now in its seventh year, of the effects of four common antiepileptic drugs (AEDs) — carbamazepine, lamotrigine, phenytoin and valproate ... National Review of Medicine

Columbia University, New York; Lamotrigine doesn't appear to impact …  -  Mar 30, 2005
2005 MAR 30 - (NewsRx.com) -- The anti-epileptic drug lamotrigine didn't ... "Subjects receiving lamotrigine had no significant reductions in calcium or ... Pay-Per-View - Biotech Week - Factiva, from Dow Jones

Epilepsy; Lamotrigine doesn't appear to impact bone turnover in young...  -  Apr 1, 2005
2005 APR 1 - (NewsRx.com) -- The anti-epileptic drug lamotrigine didn't ... "Subjects receiving lamotrigine had no significant reductions in calcium or ... Pay-Per-View - Drug Week - Factiva, from Dow Jones

Lamotrigine and oral clefts.(DRUGS, PREGNANCY, AND LACTATION) | …  -  Dec 15, 2006
Lamotrigine and oral clefts.(DRUGS, PREGNANCY, AND LACTATION) ... find Internal Medicine News articles. Historically, lithium has been a mainstay of ... Pay-Per-View - Internal Medicine News - HighBeam Research

Article: First-trimester lamotrigine use tied to defects.(Brief...  -  Nov 1, 2006
First-trimester lamotrigine use tied to defects.(Brief article) ... find Clinical Psychiatry News articles. Use of the anticonvulsant lamotrigine during the ... Pay-Per-View - Clinical Psychiatry News - HighBeam Research

Approval: generic lamotrigine tablets.(From the FDA)(Brief article)  -  Nov 1, 2006
On August 30 the FDA approved Teva Pharmaceutical's generic lamotrigine 25 mg, 100 mg, 150 mg and 200 mg tablets, indicated as adjunctive therapy for ... Free with registration - Brown University Psychopharmacology... - AccessMyLibrary.com

… Effectiveness Of LAMICTAL(R) (lamotrigine) As Adjunctive Therapy...  -  Aug 5, 2006
Data published in today's issue of Pediatrics show that lamotrigine (LAMICTAL) is an effective add-on therapy for the treatment of Primary Generalized ... Medical News Today - Medical News Today (press release)

MHRA to assess lamotrigine equivalence.(United Kingdom Medicines …  -  Mar 26, 2005
The MHRA will ensure bioequivalence is established between Lamictal and generic forms of lamotrigine when the brand's patent expires in May, ... Free with registration - Chemist & Druggist - AccessMyLibrary.com

US FDA holds up approval of lamotrigine  -  Sep 24, 2007
NEW YORK (Reuters) - US health regulators stopped short of approving a new long-acting version of the widely used epilepsy drug lamotrigine (Lamictal) until ... news Stories

Seroquel, Lamotrigine, Zyprexa  -  Jun 4, 2007
I suffer from BD 1 & recently attended a seminar on BD in Vancouver. One of their findings with regards to Seroquel is that there was very little difference ... HealthCentral.com

Approval: generic lamotrigine tablets.(From the FDA)(Brief article)  -  Nov 1, 2006
On August 30 the FDA approved Teva Pharmaceutical's generic lamotrigine 25mg, 100mg, 150mg and 200mg tablets, indicated as adjunctive therapy for partial ... Free with registration - Brown University Child and Adolescent... - AccessMyLibrary.com

Epilepsy Drug Valproate and Lamotrigine Linked To Malformed Fetus  -  Mar 23, 2005
In a study in the March issue of Neurology, the epilepsy drug Valproate has been linked to malformation of fetus when prescribed to pregnant ladies. ... MedIndia

Lower IQ Found In Children Of Women Who Took Epilepsy Drug  -  May 5, 2007
The study looked at IQ results for 187 two-year-old children of mothers who took the epilepsy drugs carbamazepine, lamotrigine, phenytoin, or valproate ... emaxhealth.com

Article: Lamotrigine effective add-on for seizures: adjunctive...  -  Apr 1, 2006
Lamotrigine effective add-on for seizures: adjunctive treatment reduces frequency of primary generalized tonic-clonic seizures. Pay-Per-View - Clinical Psychiatry News - HighBeam Research

… : Inform patients before prescribing lamotrigine.(Psychiatry)(Brief...  -  Dec 1, 2007
Inform patients before prescribing lamotrigine.(Psychiatry)(Brief article) ... find Internal Medicine News articles. MIAMI BEACH -- Inadequate informed ... Pay-Per-View - Internal Medicine News - HighBeam Research

Article: Lamotrigine called effective add-on for PGTC seizures.(Clinic...  -  Dec 1, 2005
Lamotrigine called effective add-on for PGTC seizures.(Clinical Rounds)(primary generalized tonic-clonic) ... find Pediatric News articles. Pay-Per-View - Pediatric News - HighBeam Research

Treatment of the bipolar spectrum.(NEI ACADEMY UPDATE)  -  Sep 1, 2005
Agents that are approved or have positive controlled studies in bipolar depression include the olanzapine-fluoxetine combination, lamotrigine, olanzapine, ... Free with registration - Clinical Psychiatry News - AccessMyLibrary.com

GSK receives new epilepsy approval  -  Sep 26, 2006
The approval of lamotrigine as add-on therapy for patients with PGTC seizuresis a testament to the drug's broad spectrum of activity in the treatment of ... Hays Pharma

Article: First-trimester lamotrigine use may cause oral clefts.(Women'...  -  Oct 15, 2006
First-trimester lamotrigine use may cause oral clefts.(Women's Health) ... find Internal Medicine News articles. After several years of little indication ... Pay-Per-View - Internal Medicine News - HighBeam Research

Article: Lamotrigine use rising for bipolar depression.(Adult...  -  Jun 1, 2005
Lamotrigine use rising for bipolar depression.(Adult Psychiatry) ... find Clinical Psychiatry News articles. SAN DIEGO -- Since lamotrigine gained approval ... Pay-Per-View - Clinical Psychiatry News - HighBeam Research

Brand Names/Synonyms:
Lamotrigine is also known by the following brand names and/or synonymsBW 430C; CHEMBANK1734; Lamictal; Lamictal Cd; Lamotrigina [Spanish]; Lamotrigine; Lamotrigine [Usan:Ban:Inn]; Lamotriginum [Latin]

Drug Category:
Lamotrigine is categorized under the following by the FDA: Antimanic Agents; Antidepressants; Anticonvulsants; Analgesics; Anticonvulsants; Calcium Channel Blockers; Excitatory Amino Acid Antagonists; ATC:N03AX09

Dosage Forms:
Tablet; Chewable

Absorption:
98%

Interactions:
[an error occurred while processing this directive]



Chemical IUPAC Name:
6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine





Health Home | Conditions | Cancer | Medications | Surgery | Vaccines


The Cancer News Network


Disclaimer:

Contact a physician with regard to health concerns. Email requests for further health information will be discarded.

The materials contained on this Web site are for informational purposes only and do not constitute health or medical advice. Use of information on this site does not create or constitute any kind of agreement or contract between you and the owners or users of this site, the owners of the servers upon which it is housed, or anyone else who is in any way connected with this site.

Many links on cancernewsnetwork.org lead to other sites. cancernewsnetwork.org does not sponsor, endorse or otherwise approve of the materials appearing in such sites. Nor is CancerNewsNetwork.org responsible for dead or misdirected links.

IF YOU NEED A LINK OR TEXT REMOVED FROM THIS PAGE PLEASE CONTACT cancernewsnetwork (at) live.com.
We will do our best to accommodate your request.



COPYRIGHT 2009 CANCERNEWSNETWORK | Privacy