Lescol XL

This page contains recent news articles, when available, and an overview of Lescol XL but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Lescol XL
(when available)

Pharmacology and use:
Fluvastatin, the first synthetically-prepared HMG-CoA reductase inhibitor, is used as an antilipemic to lower cholesterol and triglyceride levels associated with primary hypercholesterolemia and mixed dyslipidemia (Fredrickson types IIa and IIb) and to slow the progression of coronary atherosclerosis in patients with coronary artery disease. Although similar to lovastatin, simvastatin, and pravastatin, Fluvastatin has a shorter half-life, no active metabolites, extensive protein binding, and minimal CSF penetration. For management as an adjunct to diet to reduce elevated total-C, LDL-C, apo B, and TG levels in patients with primary hypercholesterolemia and mixed dyslipidemia

Mechanism Of Action:
Fluvastatin selectively and competitively inhibits the hepatic enzyme hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase. As HMG-CoA reductase is responsible for converting HMG-CoA to mevalonate, this results in a decrease in mevalonate, a precursor of cholesterol, and a subsequent decrease in hepatic cholesterol levels and increase in uptake of LDL cholesterol.

News Articles on Fluvastatin

Scriptlines: Lescol XL.(from Novartis Pharmaceuticals)(Brief Article)  -  Oct 22, 2005
Lescol XL 80mg tablets (fluvastatin) may be administered as a single dose at any time of the day without food, says Novartis Pharmaceuticals. $4.95 - Chemist & Druggist - ECNext

Reliant Pharmaceuticals Extends Lescol(R) Promotion Agreement  -  Apr 11, 2005
Reliant began promoting Lescol and Lescol XL in January 2001 under a five-year ... Lescol and Lescol XL are an important part of Reliant's lipid management ... RedOrbit

Press Release: Reliant Pharmaceuticals Extends Lescol(R) Promotion …  -  Apr 11, 2005
Reliant began promoting Lescol and Lescol XL in January 2001 under a ... This new indication for Lescol and Lescol XL is based on data from the first and ... Pay-Per-View - PR Newswire - HighBeam Research

Competitors by Product Report  -  Jul 19, 2008
Novartis AG (ADR) (NVS) Products:. Eon Labs Lovastatin; Lescol (Fluvastatin Sodium); Lescol XL (Fluvastatin Sodium); Sandoz Lovastatin; Sansoz Simvastatin ... $75.00 - Revere Reports - Revere

Competitors by Product Report  -  Jul 19, 2008
Novartis AG (ADR) (NVS) Products:. Eon Labs Lovastatin; Lescol (Fluvastatin Sodium); Lescol XL (Fluvastatin Sodium); Sandoz Lovastatin; Sansoz Simvastatin ... $75.00 - Revere - Alacra Store

Biovail to Market Novartis' Heart Drug in Canada  -  May 22, 2006
Biovail Corporation's Canadian sales and marketing division is to market and promote Novartis' cholesterol medicines Lescol and once-daily Lescol XL to ... RedOrbit

Lescol.(Drug overview)  -  Jan 22, 2007
Lescol XL tablets should be taken once a day at bedtime. The tablets should be swallowed whole, never crushed or chewed. You may take Lescol with or without ... Free with registration - PDR Family Guide to Prescription Drugs - AccessMyLibrary.com

Lescol.(drug overview)(Drug overview)  -  Dec 1, 2005
Lescol XL tablets should be taken once a day at bedtime. The tablets should be swallowed whole, never crushed or chewed. You may take Lescol with or without ... Free with registration - PDR Family Guide to Prescription Drugs - AccessMyLibrary.com

Statins for very-high-risk patients.(Drug Update)(Anticholesteremic...  -  Aug 1, 2005
Available as generic formulation. fluvastatin XL no generic 80 mg/dayExtended-release [Lescol XL] available formulation is the [$2.50 (80 preferred form of ... Pay-Per-View - Skin & Allergy News - HighBeam Research

Statins for very-high-risk patients.(Drug Update)  -  Aug 1, 2005
...[Lescol XL] available formulation is the [$2.50 (80 preferred form of this ... AstraZeneca (Crestor), Merck, Novartis (Lescol XL), and Pfizer. Pay-Per-View - Skin & Allergy News - Factiva, from Dow Jones

A federal judge ruled the FDA improperly denied generic drug makers …  -  Jun 1, 2006
Business Update)(receives FDA approval for Lescol XL, a ... Medical Marketing & Media; August 1, 2003 ; 700+ words ...Novartis has announced FDA approval ... Pay-Per-View - Medical Marketing & Media - HighBeam Research

Top 200 brand-name drugs by units in 2005.(rankings )  -  Mar 20, 2006
117 Dilantin Kapseals 2637 -17.2 118 Trivora-28 2630 -14.5 119 NuvaRing 2619 42.6 120 Ketek Pack 2608 255.9 121 Lescol XL 2534 -11.1 122 Necon 1/35 2529 ... Free with registration - Drug Topics - AccessMyLibrary.com

Top 200 brand name drugs by units in 2006.(COMMUNITY PRACTICE)( …  -  Mar 5, 2007
2157 21.1 135 Ditropan XL 2097 -20.7% 136 Lescol XL 2025 -20.1 137 Avodart 2021 91.0 138 Caduet 2014 82.0 139 LamisilOral 1997 -8.9 140 Ortho Tri-Cyclen ... $4.95 - Drug Topics - ECNext

Crestor warnings too weak, group says  -  Mar 11, 2005
Lescol XL. $0.2. 13.5%. Zocor. $4.6. 4.4%. Pravachol. $2.0. -1.8%. All statins. $15.5. 12.0%. Source: IMS Health, IMS National Sales Perspectives, ... Pay-Per-View - USA TODAY - ProQuest Archiver

United States top 200 brand-name drugs by retail sales in dollars and...  -  Mar 6, 2006
Fuzeon 221322 71.1 134 Thalomid 217960 28.5 135 Cefzil $216930 -9.8% 136 Zofran ODT 214014 29.8 137 Coumadin Tabs 209652 -17.2 138 Lescol XL 208515 -4.5 ... $20.00 - Drug Topics - Alacra Store

Health Canada issues advisory over statins  -  Jul 14, 2005
The medications, which include Lipitor (atorvastatin), Zocor (simvastatin), Mevacor (lovastatin), Lescol and Lescol XL (fluvastatin), ... CTV.ca

Competitors by Product Report  -  Oct 4, 2008
Novartis AG (ADR) (NVS) Products:. Lescol (Fluvastatin Sodium); Lescol XL (Fluvastatin Sodium); Sansoz Simvastatin. Perrigo Company (PRGO) Products: ... $75.00 - Revere - Alacra Store

Generics likely to beat switches in race against branded statins.(pate...  -  Jan 16, 2006
Pravachol BMS 908 -8.0 Vytorin 560 1233.3 (Schering-Plough/Merck) Crestor AstraZeneca 527 52.0 Lescol XL (Novartis) 187 -11.4 Total US statins ** 9836 ... Free with registration - Drug Store News - AccessMyLibrary.com

Press Release: Discover the Strengths and Weaknesses of Novartis …  -  May 17, 2007
Novartis has announced FDA approval for cholesterol-lowering drug Lescol XL for the indication of preventing coronary events in patients with coronary heart ... Pay-Per-View - M2 Presswire - HighBeam Research

Reliant IPO Seeking $300M To Advance Heart Portfolio  -  May 24, 2005
Lescol and Lescol XL (an extended-release formulation) are statins for high cholesterol launched in November 2000, when Reliant entered a promotion ... BioWorld Online - BioWorld Online

Press Release: Abbott's Investigational SIMCOR(R) Offers Comparable …  -  Nov 4, 2007
PR Newswire; December 16, 1999 ; 700+ words ... ... with the new formulation in the U.S., including a head-to-head comparison with LESCOL XL 80 mg versus ... Pay-Per-View - PR Newswire - HighBeam Research

Article: Will Mevacor be next? - The Record (Bergen County, NJ) | …  -  Jan 12, 2005
Lescol XL: 1.6%. Crestor: 3.8. Mevacor / Iovastatin: 1.3% (includes 1.2% for generics, 0.1% for the brand). Others: 1.2%. Prescriptions:. Lipitor: 53.4% ... Pay-Per-View - The Record - HighBeam Research

Aspreva Pharmaceuticals Corp.(MANUFACTURERS) | Article from …  -  Aug 1, 2007
...s Lescol XL (fluvastatin sodium) 80 mg, an extended-release tablet formulation of fluvastatin, a therapy that provides ... ... Pay-Per-View - Medical Marketing & Media - HighBeam Research

Loislaw Federal District Court Opinions - FITCH v. RELIANT …  -  Feb 13, 2006
Page 2 Under the program, PSRs were to get doctors to write prescriptions for Lescol XL "on any person." The PSRs would then take the prescriptions to a ... Pay-Per-View - Loislaw Federal District Court Opinions - Loislaw

Global top 200 brand-name drugs ranked by retail sales in dollars and...  -  Feb 21, 2005
Endocet 231148 90.8 115 Avalide 225070 32.9 116 Lescol XL 218382 10.7 117 Zyrtec Syrup 208884 -1.7 118 Budeprion SR 203954 NA 119 Miacalcin Nasal 201855 ... $20.00 - Drug Topics - Alacra Store

Lipitor sales to retailers led statin market in 2004.(Brief Article)(I...  -  Jun 15, 2005
Sales in billions of dollars Lipitor $7.7 Zocor $4.6 Pravachol $2.0 Crestor $0.6 Lescol XL $0.2 Note: Based on purchases, at wholesale prices, by retailers ... Free with registration - Internal Medicine News - AccessMyLibrary.com

Lipitor sales to retailers led statin market in 2004.(Brief Article)(I...  -  Jun 15, 2005
Lipitor Sales to Retailers Led Statin Market in 2004 Sales in billions of dollars Lipitor$7.7 Zocor $4.6 Pravachol $2.0 Crestor$0.6 Lescol XL $0.2 Note: ... Pay-Per-View - Internal Medicine News - HighBeam Research

Statines : Santé Canada invite à la prudence  -  Jul 14, 2005
Cette classe de médicaments comprend le Lipitor ® (atorvastatine), le Zocor ® (simvastatine), le Mevacor ® (lovastatine), le Lescol ® et le Lescol XL ... PasseportSanté.net

Brand Names/Synonyms:
Lescol XL is also known by the following brand names and/or synonymsCranoc; Fluindostatin; Fluindostatin: Lescol; Fluvastatin; Fluvastatina [Inn-Spanish]; Fluvastatine [Inn-French]; Fluvastatinum [Inn-Latin]; Lescol; Lescol Xl

Drug Category:
Lescol XL is categorized under the following by the FDA: Free Radical Scavengers; Antioxidants; Anticholesteremic Agents; HMG-CoA Reductase Inhibitors; ATC:C10AA04

Dosage Forms:
Capsules, ER tablets

Absorption:
24% (range 9%-50%).

Interactions:
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Chemical IUPAC Name:
7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-hept-6-enoicacid





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