Levobupivacaine

This page contains recent news articles, when available, and an overview of Levobupivacaine but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Levobupivacaine (when available)

Pharmacology and use:
Levobupivacaine, a local anesthetic agent, is indicated for the production of local or regional anesthesia or analgesia for surgery, for oral surgery procedures, for diagnostic and therapeutic procedures, and for obstetrical procedures. For the production of local or regional anesthesia for surgery and obstetrics, and for post-operative pain management

Mechanism Of Action:
Local anesthetics such as Levobupivacaine block the generation and the conduction of nerve impulses, presumably by increasing the threshold for electrical excitation in the nerve, by slowing the propagation of the nerve impulse, and by reducing the rate of rise of the action potential. In general, the progression of anesthesia is related to the diameter, myelination and conduction velocity of affected nerve fibers.

News Articles on Levobupivacaine

Anesthesia; Levobupivacaine has much lower neurotoxic potential than ...  -  Nov 1, 2005
In a recent study, pharmacologists in Italy "compared the neurotoxic profile of racemic bupivacaine and levobupivacaine in (i) a mouse model of ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

… plus lidocaine comparable to levobupivacaine, ropivacaine for...  -  Dec 28, 2007
When administered for peribulbar anesthesia, bupivacaine and lidocaine combined shows comparable efficacy to levobupivacaine alone and ropivacaine alone for ... OSN SuperSite

Comparative clinical trial of topical anaesthetic agents for cataract...  -  Sep 7, 2007
To assess the safety and efficacy of topical lidocaine, levobupivacaine, ... Topical anaesthesia with levobupivacaine and ropivacaine were safe, ... Nature.com

Improving epidural safety through new documentation  -  Apr 1, 2008
Levobupivacaine is now the sole available local anaesthetic for epidural infusion ... It is supplied in a pre-diluted form; as either plain levobupivacaine ... Nursing Times

Pain Medicine; Method can be a useful analgesic adjunct for early …  -  Apr 11, 2005
..."Patients in the levobupivacaine group used significantly less morphine in the first 4 hours after surgery (20.8±6.2 mg versus 33.2±10.9 mg in the placebo ... Pay-Per-View - Cardiovascular Week - Factiva, from Dow Jones

Pain Medicine; Method can be a useful analgesic adjunct for early …  -  Apr 16, 2005
..."Patients in the levobupivacaine group used significantly less morphine in the first 4 hours after surgery (20.8±6.2 mg versus 33.2±10.9 mg in the placebo ... Pay-Per-View - Obesity, Fitness & Wellness Week - Factiva, from Dow Jones

Cesarean Section; Post-cesarean section pain may be effectively...  -  Sep 12, 2006
Peak plasma concentrations of levobupivacaine were below the toxic range." The researchers concluded, "Incisional local analgesia via a subfascial catheter ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

Omni Medical Holdings Inc acquires Stat Anesthesia PC-Certain from...  -  Apr 19, 2005
M Chirocaine (levobupivacaine hydrochloride injection) Anesthesia M Synthroid (levothyroxine sodium) Hypothyroidism… ABBOTT LABORATORIES-DRUG PIPELINE ... Pay-Per-View - deals - Alacra Store

Press Release: Hospira Launches Generic Irinotecan Injection. - PR …  -  Feb 27, 2008
CHIROCAINE(TM) (levobupivacaine HCl) Injection to be an effective compound in this ... CHIROCAINE(TM) (levobupivacaine HCl) Injection in April 1998. ... Pay-Per-View - PR Newswire - HighBeam Research

Article: No knee bother as Bardsley eyes quick recovery.(News) -...  -  May 10, 2008
Postoperative analgesia of intra-articular levobupivacaine ... Regional Anesthesia and Pain Medicine; September 1, 2004 ; 643 words ... ... or in ... Pay-Per-View - Evening Chronicle - HighBeam Research

Article: Drug storage was chaotic.(News) - The Journal (Newcastle, …  -  Feb 6, 2008
Article: Effects of levobupivacaine, bupivacaine, and ropivacaine ... Regional Anesthesia and Pain Medicine; September 1, 1999 ; 700+ words . ... Pay-Per-View - The Journal - HighBeam Research

Article: Vasodilative effect of perillaldehyde on isolated rat aorta....  -  May 1, 2005
Article: Comparison of 0.25% Levobupivacaine, 0.25% Bupivacaine, and ... Regional Anesthesia and Pain Medicine; March 1, 2007 ; 700+ words ... Pay-Per-View - Phytomedicine: International Journal of... - HighBeam Research

The effect of hyaluronidase on ultrasound-measured dispersal of local...  -  May 25, 2007
McLure H, Patel A, Kumar C. A comparison of lidocaine 2% with levobupivacaine 0.75% for sub-Tenon's anaesthesia. Eur J Anaesthesiol 2005; 22: 500–503. ... Nature.com

Managing pain after thoracotomy surgery  -  May 16, 2006
A combination of a local anaesthetic (bupivacaine or levobupivacaine) and a strong opioid (fentanyl or diamorphine) is often used for their combined ... Nursing Times

Article: Ezy does it for VideoEzy - New Straits Times | HighBeam …  -  Jan 28, 2005
A bolus of levobupivacaine was injected ... following epidural placement under direct vision. Key Words: ANALGESIA, EPIDURAL ... epidural catheter had been ... Pay-Per-View - New Straits Times - HighBeam Research

How to assess epidural blockade.  -  Mar 14, 2006
The synergistic combination of a local anaesthetic (such as bupivacaine or levobupivacaine) and a strong opioid (such as fentanyl or diamorphine) in low ... Nursing Times

Pharmacokinetics | Practice | Nursing Times  -  Nov 19, 2007
Examples included esomeprazole (isomer of the proton pump inhibitor omprazole), desloratadine (isomer of the anti-histamine loratadine) and levobupivacaine ... Nursing Times

Handbook on Injectable Drugs – 14th Edition  -  Feb 4, 2008
...ertapenem, gallium nitrate, lansoprazole, levobupivacaine hydrochloride, methocarbamol,oxaliplatin, oxycodone hydrochloride, palonosetron hydrochloride, ... Medscape

Article: Purdue Pharma targets unmet needs in pain management.( …  -  May 1, 2006
Business Wire; June 15, 1999 ; 700+ words ... ... levobupivacaine) with Purdue Pharma L.P, a ... field of pain management. This agreement ... anesthesia and ... Pay-Per-View - Chain Drug Review - HighBeam Research

Hold on tight for the pharmaceuticals roller-coaster ; THE INVESTMENT...  -  Jan 23, 2007
But more important is the outlook for Levobupivacaine, a more chemically pure version of an anaesthetic produced by Astra. That is on course to be submitted ... Pay-Per-View - Independent - London - HighBeam Research

Chrysalis: Offers are at early stage | Article from The Independent -...  -  Sep 18, 2008
But ... cancer patients and many analysts said the drug was at a very early stage. More of the company's immediate hopes are pinned on Levobupivacaine ... ... Pay-Per-View - Independent - London - HighBeam Research

Article: Singapore doctors say conjoined Indonesian twins can be …  -  Apr 1, 2005
Women's Health Weekly; October 30, 2008 ; 700+ words ... ... levobupivacaine groups," wrote B.L. Sng and colleagues, KK Women's and Children's Hospital (see ... Pay-Per-View - AP Worldstream - HighBeam Research

Press Release: Debate Heightens on Non-Anesthesiologists …  -  Jul 27, 2005
The companies are also investigating the use of Chiroscience's long-acting anesthetic drug, levobupivacaine, in the PowderJect System for both dental ... Pay-Per-View - PR Newswire - HighBeam Research

약업신문 www.yakup.com  -  Apr 2, 2008
...약물�?� 국소마취제로 bupivacaine(마케�?� 주, 푸카�?� 주), levobupivacaine(염산레보 부피바카�?� 주), ropivacaine(나로핀 주) 등�?� 있고 단�?�으로 �?는 마약성 진통제 ... 약업신문

sciatic nerve (anatomy) -- Britannica Online Encyclopedia  -  Jun 5, 2008
Severe Aortic Stenosis: Combined Lumbar Plexus, Sciatic and Iliohypogastric Nerve Block with 0.25% Levobupivacaine for Reduction of Hip Fracture. ... Subscription - Encyclopedia Britannica

Brand Names/Synonyms:
Levobupivacaine is also known by the following brand names and/or synonymsChirocaine; Levobupivacaine

Drug Category:
Levobupivacaine is categorized under the following by the FDA: Anesthetics; ATC:N01BB10

Dosage Forms:
Not Available

Absorption:
Not Available

Interactions:
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Chemical IUPAC Name:
1-butyl-N-(2,6-dimethylphenyl)-piperidine-2-carboxamide

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