Lioresal

This page contains recent news articles, when available, and an overview of Lioresal but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Lioresal
(when available)

Pharmacology and use:
Baclofen is a muscle relaxant and antispastic. Baclofen is useful for the alleviation of signs and symptoms of spasticity resulting from multiple sclerosis, particularly for the relief of flexor spasms and concomitant pain, clonus, and muscular rigidity. Although Baclofen is an analog of the putative inhibitory neurotransmitter gamma-aminobutyric acid (GABA), there is no conclusive evidence that actions on GABA systems are involved in the production of its clinical effects. In studies with animals, Baclofen has been shown to have general CNS depressant properties as indicated by the production of sedation with tolerance, somnolence, ataxia, and respiratory and cardiovascular depression. Baclofen is rapidly and extensively absorbed and eliminated. Absorption may be dose-dependent, being reduced with increasing doses. Baclofen is excreted primarily by the kidney in unchanged form and there is relatively large intersubject variation in absorption and/or elimination. For the alleviation of signs and symptoms of spasticity resulting from multiple sclerosis, particularly for the relief of flexor spasms and concomitant pain, clonus, and muscular rigidity

Mechanism Of Action:
Baclofen is a direct agonist at GABAB receptors. The precise mechanism of action of Baclofen is not fully known. It is capable of inhibiting both monosynaptic and polysynaptic reflexes at the spinal level, possibly by hyperpolarization of afferent terminals, although actions at supraspinal sites may also occur and contribute to its clinical effect.

News Articles on Baclofen

Generic Name: Baclofen, Kemstro, Baclospas, pain, muscle relaxer, muscle relaxant  -  ‎Nov 11, 2009‎
Lioresal (generic name: Baclofen; brand names: Kemstro / Baclospas) belongs to a group of medicines known as muscle relaxants. Lioresal is useful for the ... Pattaya Daily News

Is there something wrong with the Bacolfen Pump, Model No. 863740 ...  -  ‎Aug 11, 2009‎
Lioresal Intrathecal (Baclofen Injection): Overview. In June of this year as reported by the Wall Street Journal, the FDA sent warning letters to Medtronic, InjuryBoard.com

The legacy of Somaliland traditional treatment is fading away due ...  -  ‎Jul 1, 2009‎
It also used for nerve and muscular problems. one of the Borama Doctors told saylac.com that Tiiro is equivalent to Lioresal (baclofen) which relieves more Saylac.com

Dépendance à l'alcool: le relaxant musculaire (baclofène) testé en ...  -  ‎Jul 1, 2009‎
...qui a été largement médiatisé, l'utilisation du baclofène (Lioresal et génériques) pour le traitement de la dépendance à l'alcool (alcoolisme) suscite PsychoMédia

Baclofène : un médicament miracle contre l’alcoolisme ?  -  ‎Apr 7, 2009‎
Depuis 1997, le Baclofène est vendu en France sous le nom de marque Lioresal, qui est en fait produit en tant que médicament générique. AgoraVox

Obituaries in the news  -  ‎Feb 22, 2009‎
He might have remained isolated from the outside world were it not for a drug, Lioresal, which restored some of his muscle function. The Associated Press

Christopher Nolan dies  -  ‎Feb 25, 2009‎
He might have remained isolated from the outside world were it not for a drug, Lioresal, which restored some of his muscle function. Monsters and Critics.com

Boy who wrote the book on courage  -  ‎Mar 16, 2009‎
After considerable struggle, partly eased by newly available Lioresal tablets, he could use a pointer strapped to his forehead his ''unicorn''. The Canberra Times

Muere novelista irland矇s Christopher Nolan  -  ‎Feb 21, 2009‎
Podr穩a haber permanecido aislado del mundo exterior si no hubiese tomado una medicina, Lioresal, que restaur籀 algunas de sus funciones musculares. Al Día (Texas)

Irlanda/ Morto a 43 anni scrittore "prodigio" Christopher Nolan  -  ‎Feb 21, 2009‎
Sarebbe rimasto isolato dal mondo esterno se un farmaco, il Lioresal, non gli avesse rimesso in funzione i muscoli di gambe e braccia. Virgilio Notizie

Baclofen pump to help muscle spasms  -  Jan 21, 2009
The brand name of the kind of baclofen used in pumps is Lioresal Intrathecal. A surgeon will put a small pump in your back, under your skin. guardian.co.uk,

Multiple sclerosis  -  Jan 21, 2009
For example, your doctor might suggest trying amantadine (Symmetrel) for tiredness, or trying tizanidine (Zanaflex) or baclofen (Lioresal) for stiff muscles guardian.co.uk,

What treatments work for tinnitus?  -  Jan 21, 2009
One small study found that the muscle relaxant baclofen (Baclospas, Lioresal) didn't help.[15] Acupuncture. This involves having thin, sterile needles put guardian.co.uk,

Drug treatments for trigeminal neuralgia  -  Jan 21, 2009
One brand name is Lioresal. Baclofen is also used to treat people with multiple sclerosis. So doctors tend to use it for people with multiple sclerosis who guardian.co.uk,

Fundusz nie może zapłacić za lioresal, bo ten drogi lek jest... za ...  -  Nov 17, 2008
Nie wiadomo, czy chora na chorobę Huntingtona pacjentka Akademickiego Centrum Klinicznego w Gdańsku dostanie na czas niezbędny leku o nazwie lioresal. Rynek Zrdowia,

Ania dostanie lek, który uchroni ją od cierpienia  -  Nov 17, 2008
To on podejmuje od lipca strategiczne decyzje finansowe, a szpital już od lipca właśnie wydał na lioresal ok. 100 tys. zł, za które NFZ nie zapłacił, NaszeMiasto.pl,

Bez leku Ania umrze z bólu  -  Nov 17, 2008
Wszczepili Ani specjalną pompę, która non stop podaje do kanału kręgowego lioresal zwiotczający mięśnie. Młoda kobieta odżyła. Wirtualna Polska,

FDA Classifies Medtronic's Notification Related to Improper ...  -  Sep 26, 2008
Patients receiving intrathecal baclofen therapy (eg Lioresal® Intrathecal) are at higher risk for adverse events as baclofen withdrawal can lead to a life WELT ONLINE,

AGI Therapeutics plc announces Interim Results  -  Sep 8, 2008
...terms of both R- and S-isomers of baclofen with the fasted exposure following a single 10mg dose of Lioresal(R) (a marketed form of racemic baclofen). MarketWatch

Pharmacologic Management of Multiple Sclerosis  -  Jul 23, 2008
Additional symptomatic treatment may include clonazepam (Klonopin(R)) and propranolol (Inderal(R)) for ataxia and tremors; baclofen (Lioresal(R)), RedOrbit,

AGI Therapeutics plc announces key findings of clinical PK study ...  -  Apr 2, 2008
...(3) There was comparable plasma exposure of R-isomer from 5mg of arbaclofen compared to 10 mg of Lioresal, confirming that the exposure to the R-isomer is FOXBusiness

AGI Therapeutics, plc announces Financial results for the twelve ...  -  Apr 3, 2008
...in terms of both R-and S-isomers of baclofen with the fasted exposure following a single 10mg dose of Lioresal(R) (a marketed form of racemic baclofen). FOXBusiness

Actavis Extends Portfolio With Four New Products in the US  -  Feb 28, 2008
Baclofen tablets: the generic equivalent of Lioresal(R) tablets by Novartis, will be available in 10mg and 20mg strengths. Baclofen tablets are used to FOXBusiness

Brand Names/Synonyms:
Lioresal is also known by the following brand names and/or synonyms:
Apo-Baclofen; Ba 34647; Baclofen; Baclon; C 34647ba; Kemstro; Lioresal; Lioresal Intrathecal; Novo-Baclofen; Nu-Baclofen; Pms-Baclofen

Drug Category:
Lioresal is categorized under the following by the FDA: Muscle Relaxants; Skeletal Muscle Relaxants; GABA Agonists; ATC:M03BX01

Dosage Forms:
TABLET; INTRATHECAL INJECTION;

Absorption:
Rapidly and extensively absorbed

Interactions:
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Chemical IUPAC Name:
4-amino-3-(4-chlorophenyl)-butanoic acid





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