Lotrisone

This page contains recent news articles, when available, and an overview of Lotrisone but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Lotrisone (when available)

Pharmacology and use:
Clotrimazole, an imidazole antifungal agent, is used for the treatment of infections caused by various species of pathogenic dermatophytes, yeasts, and Malassezia furfur. These include ringworm, candidiasis, and tinea infections. Betamethasone and clotrimazole are used together to treat cutaneous tinea infections. For the local treatment of oropharyngeal candidiasis and vaginal yeast infections, also used in fungal infections of the skin.

Mechanism Of Action:
Clotrimazole interacts with 14-α demethylase, a cytochrome P-450 enzyme that converts lanosterol to ergosterol, an essential component of the yeast membrane. In this way, clotrimazole inhibits ergosterol synthesis, resulting in increased cellular permeability. Clotrimazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms and the uptake of purine, impair triglyceride and/or phospholipid biosynthesis, and inhibit the movement of calcium and potassium ions across the cell membrane by blocking the ion transport pathway known as the Gardos channel.

News Articles on Clotrimazole

Generic Name: clotrimazole, betamethasone - ‎Nov 11, 2009‎
Lotrisone is used on the skin to treat fungal infections of the feet, groin and body. Lotrisone should be used for fungal infections that are inflamed and ... Pattaya Daily News

Brand Names/Synonyms:
Lotrisone is also known by the following brand names and/or synonymsBAY 5097; Bay B 5097; Bay B 9057; Bay-B 5097; Canesten; Canesten Cream; Canesten Solution; Canestine; Canifug; Chlotrimazole; Clotrimaderm; Clotrimaderm Cream; Clotrimazol; Clotrimazole; Clotrimazole Crystalline; Clotrimazole Znso4 Complex; Empecid; FB 5097; Femcare; Gyne Lotrimin; Gyne-Lotrimin; Gyne-Lotrimin 3; Gyne-Lotrimin 3 Combination Pack; Gyne-Lotrimin Combination Pack; Gynix; Gynixo; Lotion; Lotrimin; Lotrimin Af; Lotrimin Af Cream; Lotrimin Af Jock-Itch Cream; Lotrimin Af Lotion; Lotrimin Af Solution; Lotrimin Cream; Lotrimin Lotion; Lotrimin Solution; Lotrisone; Mono-Baycuten; Mycelax; Mycelex; Mycelex 7; Mycelex Cream; Mycelex G; Mycelex Otc; Mycelex Solution; Mycelex Troches; Mycelex Twin Pack; Mycelex-7; Mycelex-7 Combination Pack; Mycelex-G; Myclo Cream; Myclo Solution; Myclo Spray Solution; Myclo-Gyne; Mycosporin; Mykosporin; Myofug; Neo-Zol Cream; Pack; Pedisafe; Rimazole; Therapy; Travagizole; Trimysten; Trivagizole 3; Veltrim

Drug Category:
Lotrisone is categorized under the following by the FDA: Antifungals; Anti-Infectives; ATC:A01AB18; ATC:D01AC01; ATC:G01AF02

Dosage Forms:
creams, lotions, ointment, lozenges

Absorption:
Well absorbed orally but minimal if vaginal or topical

Interactions:
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Chemical IUPAC Name:
1-[(2-chlorophenyl)-diphenyl-methyl]-1H-imidazole

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