Lysodren

This page contains recent news articles, when available, and an overview of Lysodren but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Lysodren
(when available)

Pharmacology and use:
Mitotane is an oral chemotherapeutic agent indicated in the treatment of inoperable adrenal cortical carcinoma of both functional and nonfunctional types. Mitotane can best be described as an adrenal cytotoxic agent, although it can cause adrenal inhibition, apparently without cellular destruction. The administration of Mitotane alters the extra-adrenal metabolism of cortisol in man; leading to a reduction in measurable 17-hydroxy corticosteroids, even though plasma levels of corticosteroids do not fall. The drug apparently causes increased formation of 6-B-hydroxyl cortisol. For treatment of inoperable adrenocortical tumours; Cushing's syndrome

Mechanism Of Action:
Its biochemical mechanism of action is unknown, although data are available to suggest that the drug modifies the peripheral metabolism of steroids as well as directly suppressing the adrenal cortex.

News Articles on Mitotane

HRA Pharma Expands to Spain and Launches ellaOne  -  ‎Dec 18, 2009‎
...sales and distribution of ellaOne and of Lysodren, HRA Pharma's orphan drug for the symptomatic treatment of advanced adrenal cortical carcinoma. ... PharmaLive.com (press release)

MyFox Wausau | Lysodren - Uses, Side Effects, Interactions, Warnings,...  -  Mar 12, 2007
By Bristol-Myers Squibb. A side effect is an unwanted response to a medication when it is taken in normal doses. A side effect may be mild or severe, ... MyFox Wausau

MyFox Lubbock | Lysodren - Uses, Side Effects, Interactions, Warnings,...  -  Mar 12, 2007
By Bristol-Myers Squibb. Mitotane belongs to the group of cancer-fighting medications known as antineoplastics. It is used for the treatment of certain ... myFOXlubbock.com

Mitotane Delays Relapse in Adrenocortical Cancer  -  Jun 6, 2007
TURIN, Italy -- Mitotane (Lysodren), a controversial derivative of the insecticide DDT, extends relapse-free survival in cases of radically resected ... Psychiatric Times

Treatments and drugs  -  Sep 12, 2008
Medications to control excessive production of cortisol include ketoconazole (Nizoral), mitotane (Lysodren) and metyrapone (Metopirone). ... MayoClinic.com

Dog with Cushing's seems listless.  -  Apr 20, 2005
He has been on Lysodren, and it has successfully decreased his excessive thirst ... The chemotherapy drug Lysodren works well for these pets but does have ... Free with registration - Dallas Morning News - AccessMyLibrary.com

Dallas Morning News | News for Dallas, Texas | Texas Living Columnists  -  Apr 18, 2005
He has been on Lysodren, and it has successfully decreased his excessive thirst ... The chemotherapy drug Lysodren works well for these pets but does have ... Dallas Morning News

Communication cornerstone to therapeutic success: set therapy goals...  -  Apr 1, 2006
Lysodren (o,p'-DDD) therapy is initiated at home with the owner administering 25 mg/kg, given twice daily. Glucocorticoids are not routinely administered ... Free with registration - DVM Newsmagazine - AccessMyLibrary.com

Helse Bergen - Haukeland Universitetssykehus - Binyrebark kreft  -  Jun 9, 2008
Mitotan (Lysodren) hemmer utskillelsen av binyrebarkhormoner. Lysodren gis som tabletter. Konsentrasjonen av Lysodren i blodet sjekkes regelmessig. ... Helse Bergen

Treating dogs with Cushing's disease | Article from Oakland Tribune |...  -  Oct 21, 2007
Treatment involves using either a medication called Lysodren or a new medication called Trilostane. Both reduce the amount of cortisol produced by the ... Pay-Per-View - Oakland Tribune - HighBeam Research

Vet school generally takes 8 years of study  -  Jul 15, 2008
He has been getting treatment with Lysodren for some time now and seems to be ... Even though he is being treated with Lysodren, make sure his blood levels ... $2.95 - The Pantagraph - NewsBank

DOTAZ: Kolik stojí život?  -  Aug 24, 2005
Pomáhá prý jen jeden lék, Lysodren, který ale stojí 115 KÄ? týdnÄ› jedna ... O chvíli pozdÄ›ji jsem naÅ¡la venkovský zdroj, kde Lysodren byl k mání o 25,- KÄ? ... Neviditelný pes

Article: Dog with Cushing's seems listless. - The Dallas Morning News...  -  Apr 20, 2005
He has been on Lysodren, and it has successfully decreased his excessive thirst and hunger and has also stopped his frequent urination. ... Pay-Per-View - Dallas Morning News - HighBeam Research

Cancer : forum E-santé  -  Apr 15, 2006
Je reprends moi aussi du lysodren (que j'avais arrêté) et j'attends de recevoir ... Bonjour Isabelle, depuis combien de temps prends-tu le lysodren ? moi je ... E-Santé.fr

Pharmacological management of secreting pituitary tumors.( …  -  Feb 1, 2007
250 mg TID titrate per lab results Mitotane Lysodren 500 mg tablets 250-500 ... $2433/6000 mg max 6000 mg/ day Mitotane Lysodren 4-12 g divided $103/500 ... Free with registration - Journal of Neuroscience Nursing - AccessMyLibrary.com

Doggy Stars: What's Your Breed? | Article from Chicago Sun-Times | …  -  Aug 4, 2006
Chicago Sun-Times; August 16, 1995 ; 535 words ...Q. My Shih Tzu has been diagnosed with Cushing's disease. My veterinarian prescribed Lysodren to treat it. ... Pay-Per-View - Chicago Sun-Times - HighBeam Research

Pharmacological management of secreting pituitary tumors.( …  -  Feb 1, 2007
250 mg TID titrate per lab results Mitotane Lysodren 500 mg tablets 250-500 ... $2433/6000 mg max 6000 mg/ day Mitotane Lysodren 4-12 g divided $103/500 ... $4.95 - Journal of Neuroscience Nursing - ECNext

Novosti | Vecernje novosti | DruÅ¡tvo  -  Nov 17, 2005
NOVA VAROÅ  - Doze neophodnog leka lisodren (lysodren) Bojana Vujović (20) iz novovaroÅ¡kog sela RutoÅ¡i, student ViÅ¡e hotelijerske Å¡kole, smanjila je na ... Вечерње Ð?овоÑ?ти

HRA Pharma Commences US Phase III Trial of Second-Generation …  -  Dec 7, 2006
Mona-Lisa([R]), a copper contraceptive IUD (intrauterine device), and Lysodren([R]), for the treatment of adrenal cortical carcinoma. ... Free with registration - Business Wire - AccessMyLibrary.com

No sweet dreams for Rover: Cushing's disease can be a real nightmare  -  Sep 17, 2008
Instead, veterinarians use lysodren, a drug that slows the production of cortisol by destroying the outer layer of the adrenal glands. ... Marco Eagle

Cytochrome P450-Catalyzed Binding of 3-Methylsulfonyl-DDE and o,p'- …  -  Dec 1, 2008
...drug 2-(2-chlorophenyl)-2-(4-chlorophenyl)-1,1-dichlorethane; (o,p'-[ 14 C]DDD, Mitotane, Lysodren) in human adrenal tissue slice culture. ... Journal of Clinical Endocrinology and...

Corticosteroids --Glucocorticoid Effects (Systemic).  -  Feb 1, 2006
...or Carbamazepine (e.g., Tegretol) or Griseofulvin (e.g., Fulvicin) or Mitotane (e.g., Lysodren) or Phenylbutazone (e.g., Butazolidin) or Phenytoin (e.g. ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Canine Health Information - For Older Dogs  -  Mar 18, 2007
There is no cure for Cushing's disease but several drugs such as Lysodren, Ketoconazoten and Anipryl relieve symptoms and will enable your dog to live a ... Buzzle

SA: Dangerous drugs stolen, police warn | Article from AAP General...  -  Aug 19, 2005
They're especially concerned about a drug known as Lysodren, which is normally handled with gloves. If taken, it can cause damage to the adrenal gland, ... Pay-Per-View - AAP General News - HighBeam Research

Press Release: Keryx Announces Positive Final Results From Phase 2 …  -  Nov 14, 2005
DVM; April 1, 2006 ; 700+ words ... ... indicates that the induction phase of therapy has been completed ... for lysodren The maintenance phase of therapy ... Pay-Per-View - PR Newswire - HighBeam Research

Goed om weten  -  Jan 11, 2008
Mitotaan (Lysodren®) is een antitumoraal middel gebruikt voor de symptomatische behandeling van gevorderd bijnierschorscarcinoom. ... Belgisch centrum voor farmacotherapeutis...

Cancer : forum E-santé  -  Mar 11, 2006
Je comprends que cela soit difficile pour Romain mais il ne faut pas qu'il décide tout seul d'arrêter le lysodren. Il faut qu'il en parle sérieusement avec ... E-Santé.fr

A real treat: don't undermine a terrific diet with chemical-laden,...  -  Nov 1, 2007
...to treat their dog in the U.S. had to fill ... have been commonly used to treat the pituitary form of Cushing's disease in dogs: * Lysodren (mitotane . ... Pay-Per-View - Whole Dog Journal - HighBeam Research

SA: Dangerous drugs stolen | Article from AAP General News (Australia)...  -  Aug 19, 2005
..."Of concern is the drug known as Lysodren which is normally handled with gloves and if taken can cause damage to the adrenal gland, nausea, ... Pay-Per-View - AAP General News - HighBeam Research

HRA Pharma renforce sa présence européenne en ouvrant une filiale en ...  -  Dec 3, 2008
Il travaille depuis 2004 pour le compte d'HRA Pharma en tant que chargé des ventes de Lysodren, l'un des principaux produits de la société, indiqué dans le ... Caducée.net

Cancer : forum E-santé  -  Feb 16, 2006
Pour le Lysodren c'est vrai que c'est très dur. Est-ce que son taux de Lysodrénémie est bon? Bonsoir fanette, je suis en contact avec Val elle a due te ... E-Santé.fr

HRA Pharma renforce sa présence européenne en ouvrant une filiale en ...  -  Dec 11, 2008
Il travaille depuis 2004 pour le compte d'HRA Pharma en tant que chargé des ventes de Lysodren, l'un des principaux produits de la société, indiqué dans le ... InformationHospitaliere.com

Nebennierenkrebs: Wichtiger Fortschritt in der Therapie  -  Jun 8, 2007
Zwar setzen einige Nebennierenkarzinom-Spezialisten seit Jahren das Medikament Mitotane ein (Lysodren®; ein Abkömmling des Pflanzenschutzmittels DDT). ... idw-online.de

FARMACI: NASCE CENTRO COLLEGAMENTO AIFA-REGIONI  -  Jan 20, 2005
Si tratta di un farmaco orfano, il Lysodren, per il trattamento del carcinoma coricosurrenalico avanzato non operabile o recidivante e di tre generici, ... Regione Basilicata

Recente informatie  -  Dec 7, 2007
Mitotaan ( Lysodren ® ) is een antitumoraal middel gebruikt voor de symptomatische behandeling van gevorderd bijnierschorscarcinoom. ... Belgisch centrum voor farmacotherapeutis...

Wichtiger Fortschritt in der Nebennierenkrebs-Therapie  -  Jun 10, 2007
Zwar setzen einige Nebennierenkarzinom-Spezialisten seit Jahren das Medikament Mitotane ein (Lysodren®; ein Abkömmling des Pflanzenschutzmittels DDT). ... Lifegen.de - Lifegen.de (Abonnement)

Brand Names/Synonyms:
Lysodren is also known by the following brand names and/or synonymsChlodithane; Khlodithan; Lysodren; Chlodithan; Chloditan; Mitotan; Mitotanum [INN-Latin]; Lysodren

Drug Category:
Lysodren is categorized under the following by the FDA: Antineoplastic Agents; ATC:L01XX23

Dosage Forms:
TABLET

Absorption:
About 40% oral Lysodren is absorbed

Interactions:
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Chemical IUPAC Name:
1-chloro-2-[2,2-dichloro-1-(4-chlorophenyl)-ethyl]-benzene





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