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MatulaneThis page contains recent news articles, when available, and an overview of Matulane but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.Overview: Matulane (when available) Procarbazine is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer. Alkylating agents are so named because of their ability to add alkyl groups to many electronegative groups under conditions present in cells. They stop tumor growth by cross-linking guanine bases in DNA double-helix strands - directly attacking DNA. This makes the strands unable to uncoil and separate. As this is necessary in DNA replication, the cells can no longer divide. In addition, these drugs add methyl or other alkyl groups onto molecules where they do not belong which in turn inhibits their correct utilization by base pairing and causes a miscoding of DNA. Procarbazine is cell-phase specific for the S phase of cell division. For use with other anticancer drugs for the treatment of stage III and stage IV Hodgkin's disease. Mechanism Of Action: The precise mode of cytotoxic action of procarbazine has not been clearly defined. There is evidence that the drug may act by inhibition of protein, RNA and DNA synthesis. Studies have suggested that procarbazine may inhibit transmethylation of methyl groups of methionine into t-RNA. The absence of functional t-RNA could cause the cessation of protein synthesis and consequently DNA and RNA synthesis. In addition, procarbazine may directly damage DNA. Hydrogen peroxide, formed during the auto-oxidation of the drug, may attack protein sulfhydryl groups contained in residual protein which is tightly bound to DNA. News Articles on Procarbazine Risk factors for decreased fertility among male cancer survivors identified - 05 Jan 2010 ...agent dose score or treatment with cyclophosphamide or procarbazine (Matulane, Sigma-Tau) were all associated with decreased HR for siring a pregnancy. HemOncToday BioWatch: Deal fits Sigma-Tau's focus on rare diseases - Nov 12, 2009 Another prescription drug, Matulane, treats advanced Hodgkin's lymphoma. Sigma-Tau also sells over-the-counter treatments for male infertility and bowel ... Business Gazette Sumatriptan (Systemic). - Aug 1, 2006 Monoamine oxidase (MAO) inhibitor activity (isocarboxazid [eg, Marplan], phenelzine [eg, Nardil], procarbazine [eg, Matulane], selegiline [eg, Eldepryl], ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com Suit: Chemo drug led to miscarriage - Oct 19, 2007 The pharmacist at her local Walgreens instead gave her Matulane, used to treat Hodgkin's disease. The drug is designed to interfere with the growth of cells ... Pay-Per-View - Chicago Tribune - ProQuest Archiver Italian Drug Firm Draws Fire for Boosting Prices - Jun 1, 2005 The drug, Matulane, is used to treat Hodgkin's lymphoma, a rare cancer that ... The US subsidiary expects sales of $30 million this year in Matulane and its ... Subscription - Wall Street Journal Online - Dow Jones & Company … of record for Sigma-Tau Pharmaceuticals and the product MATULANE, ... - Jun 1, 2005 Wishbone/ITP has been named the agency of record for Sigma-Tau Pharmaceuticals and the product MATULANE, used along with other cancer drugs in treating ... Free with registration - Pharmaceutical Executive - AccessMyLibrary.com Tramadol and Acetaminophen ( Systemic). - Feb 1, 2006 ...and medicines with Monoamine oxidase (MAO) inhibitor activity (isocarboxazid [eg, Marplan], phenelzine [eg, Nardil], procarbazine [eg, Matulane], ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com Mo. Lawsuit Alleges Walgreen's Error Caused Miscarriage - Oct 23, 2007 Instead, Mefford said, Givens was given Matulane, a chemotherapy drug for ... An oncologist told her that by taking Matulane she faces a higher risk of ... Insurance Journal Wishbone/ITP: gutsy and triumphant turnaround after losing a third of... - Jul 1, 2006 It won its first billion-dollar drug (Abbott's Depakote for epilepsy, bipolar and migraines) and its first oncology product (SigmaTau's Matulane)--that ... Free with registration - Medical Marketing & Media - AccessMyLibrary.com Tramadol and Acetaminophen ( Systemic).(Drug overview) - May 1, 2006 ...and medicines with Monoamine oxidase (MAO) inhibitor activity (isocarboxazid [eg, Marplan], phenelzine [eg, Nardil], procarbazine [eg, Matulane], ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com Wishbone/ITP: gutsy and triumphant turnaround after losing a third of... - Jul 1, 2006 The addition of Diana Freed, chief science officer, brought expertise in areas such as oncology, which helped land the Matulane business. ... Pay-Per-View - Medical Marketing & Media - HighBeam Research Many lawsuits against pharmacies settled in silence - Feb 14, 2008 But instead, a Walgreens store in suburban St. Louis gave her Matulane, a chemotherapy drug that interferes with cell growth. ... USA Today Brain Tumor - Children Chemotherapy - Brain Tumor - Children Health … - Jun 10, 2008 PCV is an abbreviation for a chemotherapy regimen that combines procarbazine (Matulane), lomustine (CCNU), and vincristine (Oncovin). ... New York Times Walgreen Sued by Couple Claiming Wrong Prescription - Oct 18, 2007 The pharmacist at her local Walgreen drugstore instead gave her Matulane, used to treat Hodgkin's disease. The drug is designed to interfere with the growth ... Bloomberg Pleurisy. - May 1, 2007 ...not available in the United States), practolol (Eraldin; not available in the United States), procarbazine (Matulane), and sclerotherapeutic agents. ... $4.95 - American Family Physician - ECNext St. Paul Pioneer Press : MANY MEDS DON'T MIX WITH THE SUN - Sep 21, 2005 Alferon-N), metho-trexate (Mexate) pentostatin (Nipent), procarbazine (Matulane), tretinoin oral (Vesanoid), vinblastine (Velban, Velbe). ... $2.95 - St. Paul Pioneer Press - NewsBank Many pharmacy lawsuits are settled in silence - Mar 4, 2008 But instead, a Walgreens store in suburban St. Louis gave her Matulane, a chemotherapy drug that interferes with cell growth. ... Sauk Valley Newspapers Buspirone (Systemic). - Oct 27, 2005 Marplan], phenelzine [eg, Nardil], procarbazine [eg, Matulane], selegiline at doses more than 10 mg a day [eg, Eldepryl], tranylcypromine [eg, ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com Walgreens Mistakenly Replaced Prenatal Vitamins - May 2, 2008 According to the lawsuit, her prescription was instead filled with Matulane, a chemotherapy drug used to treat Hodgkin's disease. ... TransWorldNews - TransWorldNews (press release) Fentanyl (Systemic). - Jul 28, 2005 Monoamine oxidase (MAO) inhibitor activity (isocarboxazid [eg, Marplan], phenelzine [eg, Nardil], procarbazine [eg, Matulane], selegiline [eg, Eldepryl], ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com How to take Tranylcypromine from Consumer Reports Health. - Jan 8, 2007 ...pargyline (not available in the US), phenelzine (Nardil), procarbazine (Matulane), and selegiline (Eldepryl); meperidine (Demerol); sedatives; ... consumerreports.org Sertraline (Systemic). - Feb 1, 2006 Marplan], phenelzine [eg, Nardil], procarbazine [eg, Matulane], selegiline [eg, Eldepryl], tranylcypromine [eg, Parnate]) -- ( Do not take sertraline ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com Modafinil (Systemic). - Jul 28, 2005 Marplan], phenelzine [eg, Nardil], procarbazine [eg, Matulane], selegiline [eg, Eldepryl], tranylcypromine [eg, Parnate]) -- These medicines can cause ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com ESCITALOPRAM (Oral route) - es-sye-TAL-oh-pram.(Drug overview) - May 1, 2007 ...oxidase (MAO) inhibitor activity (isocarboxazid [eg, Marplan], phenelzine [eg, Nardil], procarbazine [eg, Matulane], selegiline [eg, Eldepryl], tra. Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com Atomoxetine (Systemic).(Drug overview) - May 1, 2006 Monoamine oxidase (MAO) inhibitor activity (isocarboxazid [eg, Marplan], phenelzine [eg, Nardil], procarbazine [eg, Matulane], selegiline [eg, Eldepryl], ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com How to take Isocarboxazid from Consumer Reports Health. - Jan 8, 2007 ...methylphenidate (Concerta, Metadate, Ritalin, others); other MAOIs such as phenelzine (Nardil), procarbazine (Matulane), tranylcypromine (Parnate), ... consumerreports.org Paroxetine (Systemic). - Oct 27, 2005 Marplan], phenelzine [eg, Nardil], procarbazine [eg, Matulane], selegiline [eg, Eldepryl], tranylcypromine [eg, Parnate]) -- ( Do not take paroxetine ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com Fluoxetine (Systemic).(Drug overview) - Aug 1, 2006 Marplan], phenelzine [eg, Nardil], procarbazine [eg, Matulane], selegiline [eg, Eldepryl], tranylcypromine [eg, Parnate]) -- ( Do not take fluoxetine ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com Fluoxetine (Systemic). - Jul 28, 2005 Marplan], phenelzine [eg, Nardil], procarbazine [eg, Matulane], selegiline [eg, Eldepryl], tranylcypromine [eg, Parnate]) -- ( Do not take fluoxetine ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com Sun Herald : Photosensitive medicines listed - Aug 23, 2007 Alferon-N); methotrexate (Mexate); pentostatin (Nipent); procarbazine (Matulane); tretinoin oral (Vesanoid); vinblastine (Velban, Velbe). ... $2.95 - Sun Herald - NewsBank (s.)Generic name product may be available in Canada - Oct 27, 2005 Marplan], phenelzine [eg, Nardil], procarbazine [eg, Matulane], selegiline [eg, Eldepryl], tranylcypromine [eg, Parnate]) -- If you are now taking, ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com Beta-adrenergic Blocking Agents (Systemic). - Feb 1, 2006 Marplan], isocarboxazid [e.g., Marplan], phenelzine [e.g., Nardil], procarbazine [e.g., Matulane], selegiline [e.g., Eldepryl], tranylcypromine [e.g., ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com How to take Morphine Oral from Consumer Reports Health. - Jan 4, 2006 ...(MAO) inhibitors, including isocarboxazid (Marplan), phenelzine (Nardil), procarbazine (Matulane), selegiline (Eldepryl), and tranylcypromine (Parnate). ... consumerreports.org Methylphenidate (Systemic). - Jul 28, 2005 ...phenelzine [eg, Nardil], procarbazine [eg, Matulane], selegiline [eg, Eldepryl], tranylcypromine [eg, Parnate]) -- Taking methylphenidate while you are ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com Press of Atlantic City, The : Question & Answer from the pharmacy:... - Aug 27, 2007 Alferon-N); methotrexate (Mexate); pentostatin (Nipent); procarbazine (Matulane); tretinoin oral (Vesanoid); vinblastine (Velban, Velbe). ... $2.95 - Press of Atlantic City, The - NewsBank Fluvoxamine (Systemic). - Aug 1, 2006 Marplan], phenelzine [eg, Nardil], procarbazine [eg, Matulane], selegiline [eg, Eldepryl], tranylcypromine [eg, Parnate]) -- ( Do not take fluvoxamine ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com Rizatriptan (Systemic). - Oct 27, 2005 Marplan], phenelzine [eg, Nardil], procarbazine [eg, Matulane], selegiline [eg, Eldepryl], tranylcypromine [eg, Parnate]) -- Taking rizatriptan while ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com Appetite Suppressants, Sympathomimetic (Systemic ). - Jul 28, 2005 Marplan], isocarboxazid [e.g., Marplan], phenelzine [e.g., Nardil], procarbazine [e.g., Matulane], selegiline [e.g., Eldepryl], tranylcypromine [e.g., ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com Primidone (Systemic).(Drug overview) - Aug 1, 2006 Marplan], phenelzine [eg, Nardil], procarbazine [eg, Matulane], selegiline [eg, Eldepryl], tranylcypromine [eg, Parnate]) -- Taking primidone while you ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com Ibuprofen and Oxycodone (Systemic ). - Feb 1, 2006 ...phenelzine [eg, Nardil], procarbazine [eg, Matulane], selegiline [eg, Eldepryl], tranylcypromine [eg, Parnate]) -- May increase unwanted effects; ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com Entacapone (Systemic). - Jul 28, 2005 Monoamine oxidase (MAO) inhibitors (furazolidone [eg, Furoxone]. isocarboxazid [eg, Marplan], phenelzine [eg, Nardil], procarbazine [eg, Matulane], ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com Nefazodone (Systemic).(Drug overview) - Aug 1, 2006 Monoamine oxidase (MAO) inhibitor activity (isocarboxazid [eg, Marplan], phenelzine [eg, Nardil], procarbazine [eg, Matulane], selegiline [eg, Eldepryl], ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com Diphenoxylate and Atropine (Systemic). - Jul 28, 2005 Furoxone], isocarboxazid [eg, Marplan], phenelzine [eg, Nardil], procarbazine [eg, Matulane], selegiline [eg, Eldepryl], tranylcypromine [eg, ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com Fexofenadine and Pseudoephedrine (Systemic ). - Feb 1, 2006 Monoamine oxidase (MAO) inhibitor activity (isocarboxazid [eg, Marplan], phenelzine [eg, Nardil], procarbazine [eg, Matulane], selegiline [eg, Eldepryl], ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com Levalbuterol (Inhalation-Local). - Jul 28, 2005 Nardil], procarbazine [eg, Matulane], selegiline [eg, Eldepryl], tranylcypromine [eg, Parnate]) or Tricyclic antidepressants (amitriptyline [eg, ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com Atomoxetine (Systemic). - Feb 1, 2006 Monoamine oxidase (MAO) inhibitor activity (isocarboxazid [eg, Marplan], phenelzine [eg, Nardil], procarbazine [eg, Matulane], selegiline [eg, Eldepryl], ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com Antihistamines (Systemic).(Drug overview) - May 1, 2006 Marplan], phenelzine [eg, Nardil], procarbazine [eg, Matulane], selegiline [eg, Eldepryl], tranylcypromine [eg, Parnate]) -- If you are now taking, ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com Escitalopram (Systemic). - Jul 28, 2005 Zyvox) or Monoamine oxidase (MAO) inhibitor activity (isocarboxazid [eg, Marplan], phenelzine [eg, Nardil], procarbazine [eg, Matulane], selegiline [eg, ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com Sibutramine (Systemic). - Feb 1, 2006 ...and is not recommended Monoamine oxidase (MAO) inhibitor activity (isocarboxazid [eg, Marplan], phenelzine [eg, Nardil], procarbazine [eg, Matulane], ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com Antidepressants, Tricyclic (Systemic).(Drug overview) - Aug 1, 2006 Marplan], isocarboxazid [e.g., Marplan], phenelzine [e.g., Nardil], procarbazine [e.g., Matulane], selegiline [e.g., Eldepryl], tranylcypromine [e.g., ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com Methylphenidate (Systemic).(Drug overview) - Aug 1, 2006 ...phenelzine [eg, Nardil], procarbazine [eg, Matulane], selegiline [eg, Eldepryl], tranylcypromine [eg, Parnate]) -- Taking methylphenidate while you are ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com Appetite Suppressants, Sympathomimetic (Systemic ). - Aug 1, 2006 Marplan], isocarboxazid [e.g., Marplan], phenelzine [e.g., Nardil], procarbazine [e.g., Matulane], selegiline [e.g., Eldepryl], tranylcypromine [e.g., ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com Sertraline (Systemic).(Drug overview) - May 1, 2006 Marplan], phenelzine [eg, Nardil], procarbazine [eg, Matulane], selegiline [eg, Eldepryl], tranylcypromine [eg, Parnate]) -- ( Do not take sertraline ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com Venlafaxine (Systemic).(Drug overview) - May 1, 2006 ...and is not recommended Monoamine oxidase (MAO) inhibitor activity (isocarboxazid [eg, Marplan], phenelzine [eg, Nardil], procarbazine [eg, Matulane], ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com Tramadol (Systemic). - Aug 1, 2006 Monoamine oxidase (MAO) inhibitor activity (isocarboxazid [eg, Marplan], phenelzine [eg, Nardil], procarbazine [eg, Matulane], selegiline [eg, Eldepryl], ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com Difenoxin and Atropine (Systemic).(Drug overview) - May 1, 2006 ...isocarboxazid [eg, Marplan], phenelzine [eg, Nardil], procarbazine [eg, Matulane], tranylcypromine [eg, Parnate]) -- Taking difenoxin and atropine while ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com Venlafaxine (Systemic). - Aug 1, 2006 ...and is not recommended Monoamine oxidase (MAO) inhibitor activity (isocarboxazid [eg, Marplan], phenelzine [eg, Nardil], procarbazine [eg, Matulane], ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com Modafinil (Systemic).(Provigil drug overview)(Central nervous system ... - Aug 1, 2006 Marplan], phenelzine [eg, Nardil], procarbazine [eg, Matulane], selegiline [eg, Eldepryl], tranylcypromine [eg, Parnate]) -- These medicines can cause ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com Difenoxin and Atropine (Systemic). - Aug 1, 2006 ...isocarboxazid [eg, Marplan], phenelzine [eg, Nardil], procarbazine [eg, Matulane], tranylcypromine [eg, Parnate]) -- Taking difenoxin and atropine while ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com Escitalopram (Systemic).(Drug overview) - Aug 1, 2006 Zyvox) or Monoamine oxidase (MAO) inhibitor activity (isocarboxazid [eg, Marplan], phenelzine [eg, Nardil], procarbazine [eg, Matulane], selegiline [eg, ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com Sibutramine (Systemic).(Drug overview) - Aug 1, 2006 ...and is not recommended Monoamine oxidase (MAO) inhibitor activity (isocarboxazid [eg, Marplan], phenelzine [eg, Nardil], procarbazine [eg, Matulane], ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com Atomoxetine (Systemic). - Jul 28, 2005 Monoamine oxidase (MAO) inhibitor activity (isocarboxazid [eg, Marplan], phenelzine [eg, Nardil], procarbazine [eg, Matulane], selegiline [eg, Eldepryl], ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com Primidone (Systemic). - Oct 27, 2005 Marplan], phenelzine [eg, Nardil], procarbazine [eg, Matulane], selegiline [eg, Eldepryl], tranylcypromine [eg, Parnate]) -- Taking primidone while you ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com This medicine is available only with your doctor's prescription, in... - Jul 28, 2005 Monoamine oxidase (MAO) inhibitor activity (isocarboxazid [eg, Marplan], phenelzine [eg, Nardil], procarbazine [eg, Matulane], selegiline [eg, Eldepryl], ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com Fexofenadine and Pseudoephedrine (Systemic ).(Drug overview) - May 1, 2006 Monoamine oxidase (MAO) inhibitor activity (isocarboxazid [eg, Marplan], phenelzine [eg, Nardil], procarbazine [eg, Matulane], selegiline [eg, Eldepryl], ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com Antidiabetic Agents, Sulfonylurea (Systemic). - Aug 1, 2006 ...isocarboxazid [e.g., Marplan], phenelzine [e.g., Nardil], procarbazine [e.g., Matulane], selegiline [e.g., Eldepryl], or tranylcypromine [e.g., ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com Antidiabetic Agents, Sulfonylurea (Systemic).(Disease/Disorder... - May 1, 2006 ...isocarboxazid [e.g., Marplan], phenelzine [e.g., Nardil], procarbazine [e.g., Matulane], selegiline [e.g., Eldepryl], or tranylcypromine [e.g., ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com Antihistamines and Decongestants (Systemic).(Drug overview) - Aug 1, 2006 ...phenelzine [e.g., Nardil], procarbazine [e.g., Matulane], selegiline [e.g., Eldepryl], tranylcypromine [e.g., Parnate]) -- If you are now taking, ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com Brand Names/Synonyms: Matulane is also known by the following brand names and/or synonymsCCRIS 2389; CHEMBANK3199; HSDB 3250; IBZ; Ibenzmethyzin; Ibenzmethyzine; Ibenzmethyzine Hydrochloride; MBH; MIH; Matulane; Mih Hydrochloride; NSC-77213; Nathulane; Natulan; Natulan Hydrochloride; Natulanar; Natunalar; PCB; PCX; Pcb Hydrochloride; Procarbazin; Procarbazin [German]; Procarbazina [Inn-Spanish]; Procarbazine; Procarbazine Hydrochloride; Procarbazinum [Inn-Latin]; Ro 4 6467/1 Drug Category: Matulane is categorized under the following by the FDA: Antineoplastic Agents; ATC:L01XB01 Dosage Forms: CAPSULE Absorption: Procarbazine is rapidly and completely absorbed. Interactions: [an error occurred while processing this directive] Chemical IUPAC Name: N-(1-methylethyl)-4-[(N'-methylhydrazino)methyl]benzamide |
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