Metaxalone

This page contains recent news articles, when available, and an overview of Metaxalone but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Metaxalone
(when available)

Pharmacology and use:
Metaxalone is a skeletal muscle relaxant indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomforts associated with acute, painful musculoskeletal conditions. The mode of action of this drug has not been clearly identified, but may be related to its sedative properties. Metaxalone does not directly relax tense skeletal muscles in man. For the treatment of painful musculoskeletal conditions

Mechanism Of Action:
The mechanism of action of metaxalone in humans has not been established, but may be due to general central nervous system depression.

News Articles on Metaxalone

King Pharmaceuticals: A Look Ahead to Dec 2009 Quarterly Results  -  ‎Dec 31, 2009‎
In January 2009, a US District Court acted to invalidate two of King's US patents relating to Skelaxin® (metaxalone), a muscle relaxant. ... Seeking Alpha (blog)

Generic Name: Metaxalone, pain, muscle relaxer, muscle relaxant  -  ‎Nov 11, 2009‎
Skelaxin (generic name: Metaxalone) is a muscle relaxant with a low chance of drowsiness or side effects. It can provide relief of acute, painful muscle ... Pattaya Daily News

King Pharmaceuticals Reports Strong Third Quarter 2009 Financial Results  -  ‎Nov 5, 2009‎
Net sales of SKELAXIN ® (metaxalone) totaled $102 million during the third quarter of 2009, compared to $110 million during the same period of the prior ... WELT ONLINE

The Hindu Business Line  -  Jan 29, 2005
Dabur Pharma has received the USFDA approval for its bulk drug plant in Kalyani, West Bengal, for metaxalone, a muscle relaxant. ... Hindu Business Line

King Pharma's Golden Deal  -  Jan 8, 2008
Metaxalone, or Skelaxin as called by King Pharmaceuticals, is a muscle relaxant used to relieve pain caused by strains or sprains. ... Forbes

Loislaw Federal District Court Opinions - KING PHARMACEUTICALS, …  -  Dec 1, 2008
King does not dispute that the FDA investigation is unrelated to Eon's metaxalone ANDA or its metaxalone product. Instead, King posits that if, ... Pay-Per-View - Loislaw Federal District Court Opinions - Loislaw

King Pharmaceuticals Announces Cross-License Agreement With Mutual …  -  Dec 9, 2005
Pursuant to the agreement, King will pay Mutual an upfront payment of $35 million and royalties on net sales of products containing metaxalone. ... RedOrbit

King Pharmaceuticals Reports FDA Approval of New Skelaxin(R) Label.  -  Dec 4, 2006
Metaxalone does not directly relax tense skeletal muscles in man. The most frequent reactions to metaxalone include nausea, vomiting, gastrointestinal upset ... Free with registration - Business Wire - AccessMyLibrary.com

Loislaw Federal District Court Opinions - KING PHARMACEUTICALS, …  -  Jul 15, 2008
In Page 2 particular, more than a year ago, in related litigation involving 400 mg metaxalone tablets, Eon argued to Judge Trager that "the facts and ... Pay-Per-View - Loislaw Federal District Court Opinions - Loislaw

Skeletal Muscle Relaxants (Systemic).  -  Feb 1, 2006
Studies in animals with metaxalone have not shown that it causes birth defects. ... It is not known whether chlorphenesin, chlorzoxazone, metaxalone, ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Use of Muscle Relaxants for Musculoskeletal Conditions Reviewed  -  Aug 5, 2008
Although methocarbamol and metaxalone are less sedating than tizanidine and ... Metaxalone is prescribed at 800 mg 3 to 4 times daily and is not recommended ... Medscape

'Prisoner' of Part D, Since the Medicare plan began on Jan. 1,...  -  Mar 17, 2006
Marek had been on the muscle relaxant metaxalone for years, Argoff said. But her new drug plan wouldn't pay for that drug. Argoff's staff spent six or seven ... Pay-Per-View - Newsday - ProQuest Archiver

King and Mutual to share metaxolone IP.(King Pharmaceuticals Inc. and...  -  Dec 19, 2005
As part of the deal, King will pay Mutual an upfront fee of $35.0 million and royalties on net sales of products containing metaxalone. ... Free with registration - Pharma Marketletter - AccessMyLibrary.com

国王制è?¯ä¸ŽMutual Pharma签订许å?¯å??è®®  -  Dec 10, 2005
Inc.å°±æŸ?些与metaxalone有关的智慧财产æ?ƒè¾¾æˆ?了许å?¯å??议。 æ ¹æ?®å??议,国王制è?¯å°†é¦–次 支付3500万美元给Mutual,以å?Šä»Žå?«æœ‰metaxalone的产å“?净销售收入收å?–æ?ƒåˆ©é‡‘。 ... 新浪网

Treatment of acute low back pain: use of medications: reduction and …  -  Feb 1, 2005
Metaxalone has been noted to cause little or no sedation, but its efficacy is not well supported. Opioid analgesics These agents are an option for patients ... $4.95 - Journal of Musculoskeletal Medicine - ECNext

Article: Cephalon's revenue soars with Provigil. - Philadelphia...  -  Aug 4, 2006
1987, said he believes Cephalon can get "significant penetration ... helping drive sales growth at Cephalon. Baldino pointed to Skelaxin (metaxalone ... ... Pay-Per-View - Philadelphia Inquirer - HighBeam Research

King Pharmaceuticals Reports Second-Quarter 2007 Financial Results.( …  -  Aug 7, 2007
Net sales of SKELAXIN([R]) (metaxalone) totaled $108 million during the second quarter of 2007, an increase of 11% compared to $97 million during the same ... Free with registration - Business Wire - AccessMyLibrary.com

King Pharmaceuticals Reports First-Quarter 2007 Financial Results  -  May 10, 2007
Net sales of SKELAXIN(R) (metaxalone) totaled $112 million during the first quarter of 2007, an increase of 14% compared to $99 million during the same ... Genetic Engineering News - Genetic Engineering News (press release)

King Pharmaceuticals Reports Second-Quarter 2006 Financial Results.  -  Aug 9, 2006
Net sales of Skelaxin(R) (metaxalone) totaled $97 million during the second quarter of 2006, an increase of 12% compared to $87 million during the same ... Free with registration - Business Wire - AccessMyLibrary.com

King Pharmaceuticals Completes Strategic Acquisition of AVINZA(R)  -  Feb 26, 2007
SKELAXIN(R) (metaxalone): For patients with acute, painful musculoskeletal conditions as an adjunct to rest, physical therapy and other measures. ... Genetic Engineering News - Genetic Engineering News (press release)

PRESS RELEASE: King Pharmaceuticals to Cut Costs, 20 Percent of …  -  Oct 19, 2007
In recent years, King has developed a strong pain management franchise, which includes existing products like SKELAXIN® (metaxalone) and AVINZA® (morphine ... FierceBiotech

King Pharmaceuticals Reports Second-Quarter 2008 Financial Results  -  Aug 7, 2008
Net sales of SKELAXIN(R) (metaxalone) totaled $107 million during the second quarter of 2008, compared to $108 million during the same period of the prior ... Genetic Engineering News - Genetic Engineering News (press release)

King Pharmaceuticals Joins Together Rx Access(TM) To Help Americans …  -  Jun 11, 2007
Skelaxin(R) (metaxalone); Avinza(R)(morphine sulfate extended release); Sonata(R) (zaleplon); and Levoxyl(R) (levothyroxine sodium tablets, USP). ... Genetic Engineering News - Genetic Engineering News (press release)

King Pharmaceuticals Reports First-Quarter 2005 Financial Results  -  Sep 5, 2005
...particularly with respect to Altace(R) (ramipril) and Skelaxin(R) (metaxalone), and significantly higher net sales of Thrombin-JMI(R) (thrombin, ... Euro am Sonntag

King Pharmaceuticals Reports First-Quarter 2006 Financial Results  -  Sep 5, 2006
Net sales of Skelaxin(R) (metaxalone) totaled $99 million during the first quarter of 2006, an increase of 37% compared to $72 million during the same ... Euro am Sonntag

How effective are muscle relaxers?  -  Aug 10, 2008
Cyclobenzaprine hcl has the most recent and largest clinical trials demonstrating its benefit, but , diazepam and metaxalone also appear to be effective. ... MedIndia

What Are Headaches? What Causes Headaches?  -  Jun 13, 2007
Some patients find that metaxalone (Skelaxin), a non-sedating muscle relaxant helps. In the most severe cases patients have improved when given a ... Medical News Today - Medical News Today (press release)

King Pharmaceuticals Reports Third-Quarter 2005 Financial Results  -  Sep 11, 2005
Net sales of Skelaxin(R) (metaxalone) increased 92% to $115.9 million during the third quarter of 2005 from $60.4 million during the same period of the ... Euro am Sonntag

King Pharmaceuticals Reports Third-Quarter 2007 Financial Results.( …  -  Nov 8, 2007
Net sales of SKELAXIN([R]) (metaxalone) totaled $106 million during each of the third quarters of 2007 and 2006. THROMBIN-JMI([R]) (thrombin, topical, ... Free with registration - Business Wire - AccessMyLibrary.com

King Pharma ends Skelaxin patent suit; CorePharma will get generic …  -  Jan 11, 2008
...based King said it signed a metaxalone 800 mg product agreement on Jan. 2 granting CorePharma certain rights for an authorized generic version of the ... Kingsport Times News

King Pharmaceuticals Announces Strategic Acquisition of Avinza(R)...  -  Sep 7, 2006
...--SKELAXIN(R) (metaxalone): A non-narcotic and non-addictive muscle relaxant that brings relief to muscle regions affected by pain and discomfort, ... Free with registration - Business Wire - AccessMyLibrary.com

King's 2nd-qtr sales rise 8%, Rx income up 5%.(financial report)(Finan...  -  Aug 21, 2006
...jumped 7% $154.0 million, while the muscle relaxant Skelaxin (metaxalone) increased 12% to $97.0 million. Sales of the coagulant Thrombin-JMI (thrombin, ... Free with registration - Pharma Marketletter - AccessMyLibrary.com

Lose that pain in the neck: simple treatments can alleviate most neck...  -  Oct 1, 2007
While muscle relaxants--carisoprodol, metaxalone and others--may alleviate acute neck pain, they're not so effective for chronic pain, Dr. Mazanec said. ... Free with registration - Men's Health Advisor - AccessMyLibrary.com

CorePharma to Sell Authorized Generic Skelaxin  -  Jan 16, 2008
Under the agreement relating to 800-mg Skelaxin (metaxalone) tablets, CorePharma's license will go into effect Dec. 1, 2012, or six months after the US ... FDA news - FDA news (subscription)

King Pharmaceuticals and Pain Therapeutics Enter Into Strategic...  -  Nov 10, 2005
King's growing line of branded products includes neuroscience drugs such as Skelaxin(R) (metaxalone) and Sonata(R) (zaleplon). ... $4.95 - PR Newswire - ECNext

King sees 1st-qtr earnings drop 28% to $51M.(Brief article)  -  May 29, 2006
...sales of which contributed $159.0 million, up 85% on the first quarter of last year; revenues from its muscle relaxant Skelaxin (metaxalone) rose 37% to ... Free with registration - Pharma Marketletter - AccessMyLibrary.com

BENZODIAZEPINE (Oral route, Parenteral route, Rectal route).(Drug …  -  May 1, 2007
Metaxalone * Methocarbamol * Methohexital * Mibefradil * Morphine * Morphine Sulfate Liposome * Omeprazole * Oxycodone * Oxymorphone * Pentobarbital ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Cape Cod Times : Falmouth District Court  -  Feb 21, 2008
ANDRADE, Douglas H. Jr., 20, 65 O'Donnell Ave., East Falmouth; possessing marijuana, possessing metaxalone, Friday in Falmouth. Pretrial hearing March 25. ... $2.95 - Cape Cod Times - NewsBank

Kava.  -  May 1, 2006
Medicines used for muscle spasms (examples: Carisoprodol (Soma(R)); Methocarbamol (Robaxin(R)); Metaxalone (Skelaxin(R))) * Tacrine (Cognex(R)) ... Free with registration - AltCareDex Alternative Medicines - AccessMyLibrary.com

Cape Cod Times : Falmouth District Court  -  Jun 30, 2008
15 in Falmouth, continued six months without a guilty finding; possessing metaxalone, dismissed. ANDREWS, Michael P., 20, 242 East Falmouth Highway, ... $2.95 - Cape Cod Times - NewsBank

King Pharmaceuticals Reports First-Quarter 2005 Financial Results.  -  May 9, 2005
...particularly with respect to Altace(R) (ramipril) and Skelaxin(R) (metaxalone), and significantly higher net sales of Thrombin-JMI(R) (thrombin, ... $4.95 - PR Newswire - ECNext

King Pharmaceuticals Accelerates Strategic Shift to Maximize Long...  -  Oct 18, 2007
In recent years, King has developed a strong pain management franchise, which includes existing products like SKELAXIN([R]) (metaxalone) and AVINZA([R]) ... $4.95 - Business Wire - ECNext

King Pharmaceuticals Reports Third-Quarter 2005 Financial Results.  -  Nov 9, 2005
Net sales of Skelaxin(R) (metaxalone) increased 92% to $115.9 million during the third quarter of 2005 from $60.4 million during the same period of the ... $4.95 - PR Newswire - ECNext

King Pharmaceuticals Reports First-Quarter 2006 Financial Results.  -  May 9, 2006
Net sales of Skelaxin(R) (metaxalone) totaled $99 million during the first quarter of 2006, an increase of 37% compared to $72 million during the same ... $4.95 - PR Newswire - ECNext

Loislaw Federal District Court Opinions - KING PHARMACEUTICALS, …  -  Dec 4, 2008
...the "factual bas[e]s" for "King's contention[s]" or (in the case of Topic 34) "King's understanding of how Eon will sell its 800 mg metaxalone product . ... Pay-Per-View - Loislaw Federal District Court Opinions - Loislaw

US workers' comp Rx costs rate of rise slows, but expensive new drugs...  -  May 2, 2005
...such as Pfizer's Zoloft (sertraline), sleep aids including Sanofi-Aventis' Ambien (zolpidem) and muscle relaxants, eg, King Pharma's Skelaxin (metaxalone). $4.95 - Pharma Marketletter - ECNext

Federal Register 2007 - 72 FR 30386 Draft Guidances for Industry …  -  May 31, 2007
Sodium Losartan Potassium M Mefloquine HCl Meloxicam (multiple dosage forms) Mercaptopurine Mesalamine Metaxalone Metformin HCl Metformin HCl; ... Pay-Per-View - Federal Register 2007 - Loislaw

King's profit drops 34% in 2nd-qtr 2008 to $43M.  -  Aug 18, 2008
Sales of muscle relaxant Skelaxin (metaxalone) were largely flat at $107.0 million versus $108.0 million in second-quarter 2007, while hemostatic agent ... $9.94 - Pharma Marketletter - Alacra Store

King's 3rd-qtr revenue drops 5% to $492M.  -  Nov 27, 2006
Sales of Altace (ramipril), King's cardiovascular drug, totaled $159.0 million vs $174.0 million, while the muscle relaxant Skelaxin (metaxalone) fell to ... $9.94 - Pharma Marketletter - Alacra Store

King's 2nd-qtr revenue rises 9%, net income falls.  -  Aug 20, 2007
Sales of Altace (ramipril), King's cardiovascular drug, rose to $163.0 million from $154.0 million, while the muscle relaxant Skelaxin (metaxalone) earned ... $9.94 - Pharma Marketletter - Alacra Store

King Pharma third qtr revenues up 31%.(King Pharmaceuticals Inc.)(Brie...  -  Nov 21, 2005
..." In addition, the firm notes that sales of its products Skelaxin (metaxalone), Thrombin JM (thrombin, topical, bovine USP) and Levoxyl (levothyroxine ... $4.95 - Pharma Marketletter - ECNext

Press Release: King Pharmaceuticals Reports First-Quarter 2005 …  -  May 9, 2005
...particularly with respect to Altace(R) (ramipril) and Skelaxin(R) (metaxalone), and significantly higher net sales of Thrombin-JMI(R) (thrombin, ... Pay-Per-View - PR Newswire - HighBeam Research

Options for osteoarthritis pain: despite concerns about certain pain ...  -  Jul 1, 2006
Muscle relaxants (carisoprodol, chlorzoxazone, cyclobenzaprine, methocarbamol, metaxalone, oxybutynin) * Nifedipine, short-acting * Nitrofurantoin * NSAIDs, ... Pay-Per-View - Men's Health Advisor - HighBeam Research

Janssen's Invega.(PRODUCT NEWS) | Article from Medical Marketing & …  -  Feb 1, 2007
Elan has announced FDA approval for a new 800 mg strength version of Skelaxin (metaxalone) for the treatment of acute pain in musculoskeletal conditions. ... Pay-Per-View - Medical Marketing & Media - HighBeam Research

King Pharmaceuticals Appoints Joseph Squicciarino Chief Financial …  -  Jun 1, 2005
Altace(R) (ramipril), Skelaxin(R) (metaxalone), Levoxyl(R) (levothyroxine sodium tablets, USP), Sonata(R) (zaleplon) and Thrombin-JMI(R) (thrombin, ... $4.95 - PR Newswire - ECNext

King's 1st-qtr 2007 revenue increases 7%.  -  May 21, 2007
Top performers included the muscle relaxant Skelaxin (metaxalone) which earned $112.0 million, an increase of 14%, while sales of the firm's ... $9.94 - Pharma Marketletter - Alacra Store

GlaxoSmithKline.(Pipeline) | Article from Medical Marketing & Media |...  -  Aug 1, 2006
Elan has announced FDA approval for a new 800 mg strength version of Skelaxin (metaxalone) for the treatment of acute pain in musculoskeletal conditions. ... Pay-Per-View - Medical Marketing & Media - HighBeam Research

Loislaw Federal District Court Opinions - WRENN v. BARNHART (NH …  -  Jun 27, 2005
Dr. Thies thus concluded that Wrenn's discomfort may have resulted from musculoskeletal etiology[fn6] and prescribed Metaxalone.[fn7] Four weeks later, ... Pay-Per-View - Loislaw Federal District Court Opinions - Loislaw

TALK TO THE DOC Back pain can be wake-up call  -  Jun 20, 2007
Prescription muscle relaxants such as cyclobenzaprine (Flexeril) and metaxalone (Skelaxin) also appear to be effective. ... $2.95 - Ojai Valley News - NewsBank

Shire's Lialda.(PRODUCT NEWS) | Article from Medical Marketing & …  -  Mar 1, 2007
Elan has announced FDA approval for a new 800 mg strength version of Skelaxin (metaxalone) for the treatment of acute pain in musculoskeletal conditions. ... Pay-Per-View - Medical Marketing & Media - HighBeam Research

PHARMtechexpo 2005 Exhibitor Profiles.  -  Feb 7, 2005
METAXALONE 11.MICONAZOLE BASE 12.MICONAZOLE NITRATE 13.OXYBUTYNIN HYDROCHLORIDE 14.SALBUTAMOL BASE 15.SALBUTAMOL SULPHATE 16.TIMOLOL MALEATE 17. ... $4.95 - Business Wire - ECNext

King Pharmaceuticals Reports Second-Quarter 2005 Financial Results.  -  Aug 9, 2005
Net sales of Skelaxin(R) (metaxalone) increased 71% to $86.8 million during the second quarter of 2005 from $50.9 million during the same period of the ... $4.95 - PR Newswire - ECNext

Press Release: King Pharmaceuticals Reports Third-Quarter 2005 …  -  Nov 9, 2005
Net sales of Skelaxin(R) (metaxalone) increased 92% to $115.9 million during the third quarter of 2005 from $60.4 million during the same period of the ... Pay-Per-View - PR Newswire - HighBeam Research

King Pharmaceuticals Announces Appointment of Eric J. Bruce as …  -  Jun 10, 2005
Altace(R) (ramipril), Skelaxin(R) (metaxalone), Levoxyl(R) (levothyroxine sodium tablets, USP), Sonata(R) (zaleplon) and Thrombin-JMI(R) (thrombin, ... $4.95 - PR Newswire - ECNext

King Pharma 1st-qtr income rises 26%.(Brief Article)  -  May 23, 2005
...particularly for Altace (ramipril) and Skelaxin (metaxalone), and significantly higher net sales of Thrombin-JMI (thrombin, topical, bovine). $4.95 - Pharma Marketletter - ECNext

Georgia Code - 16-13-71. (a) A "dangerous drug" means any drug other ...  -  Aug 4, 2005
...(572) Metaxalone; (572.5) Metformin; (573) Methacholine; (574) Methacycline; (575) Methallenestril; (576) Reserved; (577) Reserved; (578) Methantheline; ... Pay-Per-View - Georgia Code - Loislaw

Article: Second quarter drives Novartis towards record. - The Evening...  -  Jul 14, 2005
Article: FDA Responds to Eon Labs' Metaxalone Biostudy. Business Wire; March 24, 2003 ; 665 words ... ... BUSINESS WIRE)--March 24, 2003 Eon Labs, ... Pay-Per-View - Evening Standard - HighBeam Research

Article: Novartis snaps up German rival. - The Evening Standard...  -  Feb 21, 2005
Article: FDA Responds to Eon Labs' Metaxalone Biostudy. Business Wire; March 24, 2003 ; 665 words ... ... BUSINESS WIRE)--March 24, 2003 Eon Labs, ... Pay-Per-View - Evening Standard - HighBeam Research

Article: Novartis creates a drugs giant with [pounds sterling]3.9bn...  -  Feb 21, 2005
Article: FDA Responds to Eon Labs' Metaxalone Biostudy. Business Wire; March 24, 2003 ; 665 words ... ... BUSINESS WIRE)--March 24, 2003 Eon Labs, ... Pay-Per-View - Evening Standard - HighBeam Research

Brand Names/Synonyms:
Metaxalone is also known by the following brand names and/or synonyms.Meta.Xalon; .Meta.Xalone; .Meta.Zalone; .Meta.Zolone; AHR 438; AHR-438; HSDB 3236; Metassalone [Dcit]; Metaxalon; Metaxalona [Inn-Spanish]; Metaxalona [Spanish]; Metaxalone; Metaxalone [Usan:Ban:Inn]; Metaxalonum [Inn-Latin]; Metaxalonum [Latin]; Metazalone; Metazolone; Methaxalonum; Methoxolone; Skelaxin; Zorane

Drug Category:
Metaxalone is categorized under the following by the FDA: Muscle Relaxants, skeletal muscle; Analgesics; Hypnotics and Sedatives;

Dosage Forms:
Tablet

Absorption:
Not Available

Interactions:
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Chemical IUPAC Name:
5-[(3,5-dimethylphenoxy)methyl]oxazolidin-2-one





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