Methadone

This page contains recent news articles, when available, and an overview of Methadone but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Methadone
(when available)

Pharmacology and use:
Methadone is a synthetic opioid analgesic with multiple actions quantitatively similar to those at morphine, the most prominent of which involve the central nervous system and organs composed of smooth muscle. However, Methadone is more active and more toxic than morphine. Methadone is indicated for relief of severe pain, for detoxification treatment of narcotic addiction, and for temporary maintenance treatment of narcotic addiction. The principal actions of therapeutic value are analgesia and sedation and detoxification or temporary maintenance in narcotic addiction. The Methadone abstinence syndrome, although qualitatively similar to that of morphine, differs in that the onset is slower, the course is more prolonged, and the symptoms are less severe. For the treatment of dry cough, drug withdrawal syndrome, opioid type drug dependence,pain

Mechanism Of Action:
Opiate receptors are coupled with G-protein receptors and function as both positive and negative regulators of synaptic transmission via G-proteins that activate effector proteins. Binding of the opiate stimulates the exchange of GTP for GDP on the G-protein complex. As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine and noradrenaline is inhibited. Opioids also inhibit the release of vasopressin, somatostatin, insulin and glucagon. Methadone's analgesic activity is, most likely, due to its conversion to morphine. Opioids close N-type voltage-operated calcium channels (OP2-receptor agonist) and open calcium-dependent inwardly rectifying potassium channels (OP3 and OP1 receptor agonist). This results in hyperpolarization and reduced neuronal excitability. Methadone has a unique affinity for the NMDA brain receptor. It is believed that NMDA (N-methyl-D-aspartic acid) may regulate psychic dependence and tolerance by exhibiting opioid antagonist-like activity.

News Articles on Methadone

Drop-in Center: Major Russian Paper Wrote about Ukrainian Experience in Harm ...  -  14 Nov 2009
This is “the site� – a place where patients of substitution therapy receive pills of Methadone and Buprenorphine. There are no very young people in line. ... Global Voices Online (blog)

Officials searching for dead man's family  -  14 Nov 2009
Freemen had a prescription for methadone, and was being treated for pancreatic cancer. He had just picked up a prescription for the medicine Friday night ... Muncie Star Press

Murderer gets parole to receive treatment for drug abuse  -  14 Nov 2009
Most recently, in October 2008, he stole a bottle of methadone while in a medium-security prison. "In March 2009 his girlfriend alerted the drug dogs on two ... Telegraph-Journal

Candidate's Campaign Suspended After Drug Bust  -  14 Nov 2009
Harris said the charges that he was trafficking prescription painkillers, including Xanax, methadone, and oxycodone, were just a smokescreen for a political ... Central Florida News 13

KRISTA MADER: Methadone clinic would help area  -  ‎Nov 13, 2009‎
It was about Blairsville Borough council turning down a request for a methadone clinic to be opened there. (Read more local comment and opinion today in the ... Indiana Gazette

Methadone blues  -  ‎Nov 13, 2009‎
Prescription-drug addicts are filling methadone clinics like his for help. Charla Jones/The Globe and Mail From Saturday's Globe and Mail Published on ... Globe and Mail

Judge dismisses lawsuit over methadone clinic  -  ‎Nov 13, 2009‎
The next move is up to the state Division of Addiction of Services, which still wants to have a methadone clinic within the port. ... Cherry Hill Courier Post

Bioniche Pharma acquires Duraclon(R) and Methadone Hydrochloride injection USP ...  -  ‎Nov 13, 2009‎
LLC has acquired Duraclon(R) (clonidine hydrochloride injection) and Methadone Hydrochloride Injection USP from Xanodyne Pharmaceuticals, Inc., ... Trading Markets (press release)

County opening methadone clinic in Columbia  -  ‎Nov 12, 2009‎
The Howard County Health Department plans to open a methadone clinic next spring at its offices on Columbia Gateway Drive, ... Explore Howard County

Bioniche Pharma Acquires Duraclon(R) (clonidine hydrochloride injection) and ...  -  ‎Nov 12, 2009‎
Methadone Hydrochloride Injection USP has black box warnings relating to peri-operative pain management and to conditions for distribution and use for the ... PR Newswire (press release)

Methadone still a problem in area  -  ‎Nov 12, 2009‎
Three people died from methadone overdoses between February and June, and another died with a mixture of methadone and another drug in his system. ... Traverse City Record Eagle

Calgary methadone clinic hit by complaints - again  -  ‎Nov 11, 2009‎
Second Chance, a methadone clinic, received the OK from the city to move into a strip mall in the Foothills Industrial Park, but the appeals mean there will ... Calgary Herald

Impairment debated in trial over officer's death  -  ‎Nov 11, 2009‎
Bucks County Deputy District Attorney Robert James said Budka "should have been aware" that smoking marijuana while on prescribed amounts of methadone and ... Philadelphia Inquirer

Driver guilty in officer's death  -  ‎Nov 13, 2009‎
Budka, who suffered a shattered patella in the crash, has for years used prescribed methadone. His doctor had him sign a document stating he knew he was not ... phillyBurbs.com

Most Who OD on Prescription Opiates Took Methadone  -  ‎Nov 4, 2009‎
Methadone was the cause of death in 64 percent of these cases, followed by oxycodone (23 percent) and hydrocodone (14 percent). The biggest percentage of ... ABC News

More Than 30 Defendants Indicted on Prescription Pill Charges in Historic Drug ...  -  ‎Oct 29, 2009‎
The indictments also allege there were more than 50 counts of distribution of controlled substances (oxycodone, methadone), conspiracy to distribute ... Reuters

Russia policies slammed at HIV conference  -  ‎Oct 28, 2009‎
Russia's chief medical official Gennady Onishchenko told a major AIDS conference that Moscow opposed providing methadone -- a synthetic drug that is not ... AFP

Methadone Suspected In Crash With Bus Carrying People With Disabilities  -  ‎Nov 11, 2009‎
Entertainment News from AP By Megahn Snyder (WICHITA, Kan.) Police say a prescription drug may have played a part in a morning crash involving a bus ... KWCH

Methadone clinic may move  -  ‎Nov 10, 2009‎
San Mateo County's only methadone clinic could draw more patients and stop draining money from county coffers by moving from Menlo Park to a more ... San Mateo Daily Journal

Study: Methadone common cause for painkiller deaths  -  ‎Oct 30, 2009‎
A new study suggests that methadone is commonly a culprit in prescription opioid deaths--and that Medicaid enrollees could be at particular risk. ... FierceHealthcare

Ill. doctor admits illegally dispensing drugs  -  ‎Nov 5, 2009‎
Although it is best known as a prescription drug that curbs heroin addiction, methadone increasingly has been prescribed as a pain medication. ... Chicago Tribune

Barrett will decide on governor race this week  -  ‎Nov 10, 2009‎
Waukesha - A 35-year-old Waukesha woman was sentenced to 10 years in prison Tuesday for providing methadone on separate occasions to two people who ... Milwaukee Journal Sentinel

Residents protest methadone clinic  -  ‎Nov 9, 2009‎
Lane Leckerman protests the opening of a methadone clinic Monday morning, which opened on Philmont Avenue in Lower Moreland. By Jesse Reilly Holding signs ... Montgomery Newspapers

Community embraces drug addiction centre  -  ‎Nov 13, 2009‎
CALGARY - A northeast community that once banished a controversial methadone clinic from ... Calgary Herald

Cops: Mastic Man Robbed Pharmacies for Methadone  -  ‎Nov 6, 2009‎
...allegedly robbed pharmacies at gunpoint or with scissors for methadone, a drug used to treat heroin addicts, between November 2004 and February 2005. ... LongIslandPress.com

Patricia Williams pleads no contest in overdose death of niece Chesica Leisner  -  ‎Nov 12, 2009‎
Patricia Williams supplied the methadone that Chesica Leisner took before being found dead in her North Washington Street apartment on Aug. 25. ... Green Bay Press Gazette

Methadone Treatment Controversial As Methadone Deaths Mount  -  ‎Nov 10, 2009‎
The Atlanta Recovery Center Drug Rehab in Georgia warns that methadone abuse continues despite evidence that methadone misuse can cause death. ... TransWorldNews (press release)

Meth lab discovered in mobile home  -  ‎Nov 10, 2009‎
Investigators also found meth and methadone, the sheriff said. Methadone is a narcotic pain reliever often prescribed to help detoxify heroin addicts. ... SunHerald.com (registration)

Suspect who died in Garda station told doctor he used methadone  -  ‎Nov 6, 2009‎
A MAN who died of methadone poisoning in a Dublin Garda station, where he was being detained for questioning about the fatal shooting of a young mother, ... Irish Times

Hooked: Canada's painkiller problem  -  ‎Nov 13, 2009‎
Prescription-drug addicts are filling methadone clinics like his for help. Mr. Winger got his first taste of prescription drugs at the age of 17, ... Globe and Mail

BLAIRSVILLE: Council turns down request to allow methadone clinic  -  ‎Nov 7, 2009‎
Bonnarigio wants to lease the former Eagle Mine Service building along Route 22 to Medtech Rehabilitation LLC, a Greensburg-based methadone clinic. ... Indiana Gazette

Psychiatrist testifies that Anna Nicole Smith walked away from drug treatment  -  ‎Oct 19, 2009‎
The model was 15 weeks pregnant in 2006 when she left Cedars-Sinai Medical Center, where she was being treated for methadone and Xanax addiction. ... Los Angeles Times

Community Outraged Over Proposed Methadone Clinic  -  ‎Nov 2, 2009‎
From the mayor to the police chief, the county attorney and hospital executives, when it comes to the opening and operation of a methadone clinic, ... WLKY.com

Successful Methadone detox from Novus Medical Detox Center  -  ‎Nov 10, 2009‎
...“The people are amazing!!! My 10 day stay at Novus was like no detox I could imagine. The food was great, amenities were amazing and again, the people are ... TransWorldNews (press release)

Brokenshire - Methadone overdoses  -  ‎Nov 11, 2009‎
...or secondary diagnosis of 10 Nov 2009 : Column 258W methadone overdose in each of the last five years; and how many of those died following admission. ... DeHavilland (press release) (subscription)

Dangers in methadone programme  -  ‎Nov 10, 2009‎
Clinicians are being advised to pay greater attention to patients' health before and while they are on the methadone programme. The advice comes following ... NZ City

Court Case Marks Dangerous Trend With Prescription Drugs  -  ‎Nov 5, 2009‎
Methadone. It's a highly addictive narcotic, commonly used to help detoxify heroine addicts. But it can also be deadly. That's what happened to Akron, ... KCAU

Anna Nicole's doc wrote about kissing her in diary  -  ‎Oct 28, 2009‎
..."I gave her methadone, Valium. Can she ruin me?" The entry also recounted his ride with Smith in a gay pride parade before the party, with six police ... The Associated Press

Health panel rejects proposed Avondale methadone clinic  -  ‎Oct 22, 2009‎
MONTGOMERY - State health regulators Wednesday rejected a proposal to open a methadone clinic in Birmingham's Avondale neighborhood amid opposition from ... al.com

Clinic's application shows little support  -  ‎Nov 10, 2009‎
By BOB WHITE ELIZABETHTOWN – Portions of E-Town Addictions Solutions' state application to operate a methadone clinic in Elizabethtown were released to The ... News Enterprise

Calgary methadone clinic finds new home after two forced moves  -  ‎Oct 27, 2009‎
The city has given approval for Second Chance Clinic to operate in a shopping centre in Foothills Industrial Park, the lawyer for the methadone clinic's ... Calgary Herald

Driver fighting charge in death of Bucks officer  -  ‎Nov 10, 2009‎
Budka, who's being held in Bucks County Prison on $1 million bail, had been prescribed methadone as a treatment for pain and was being treated for ... phillyBurbs.com

Fadi Ibrahim made to wait for bail decision  -  ‎Oct 22, 2009‎
Yesterday Mr Ibrahim had told the court he did not want to be given methadone as an alternative medication to dull the pain of his injuries. ... Sydney Morning Herald

NO WITHDRAWAL PAIN?  -  ‎Nov 10, 2009‎
Many people who have become dependent on or addicted to heroin, OxyContin (legal heroin), methadone, Vicodin and other narcotic drugs say that the biggest ... TransWorldNews (press release)

Says county needs methadone clinic  -  ‎Nov 4, 2009‎
People of Bellingham, if you won't OK a methadone clinic on humanitarian grounds, how about your pocketbook? Suboxone isn't enough for big habits. ... Bellingham Herald

Sentencing date set for former coroner  -  ‎Nov 10, 2009‎
Gary Hazen, 53, pleaded guilty in July to possession of the painkiller hydrocodone and methadone, a drug used to combat withdrawal symptoms. ... Billings Gazette

Board OKs Columbia Methadone Clinic  -  ‎Oct 21, 2009‎
By a 3-1 vote, the board members disagreed with the city's assertion that Recovery of Columbia's proposed methadone clinic is the same as a rehabilitation ... WSMV

Proposed methadone clinic put on hold in Blairsville  -  ‎Oct 22, 2009‎
BLAIRSVILLE -- A proposal for bringing an outpatient methadone clinic for treatment of drug addiction to a ... Blairsville Dispatch

Poll Results  -  ‎Nov 11, 2009‎
Blairsville Borough council recently voted to deny a variance that would have allowed a methadone clinic to open in the borough. What would you think about ... Indiana Gazette

Location Of Mobile Clinic Puts Patients' Lives At Risk  -  ‎Nov 9, 2009‎
MacMillan and his brother Scott say the city of Seattle and Evergreen Treatment Services told them last July that ETS would be parking its mobile methadone ... KIROtv.com

Methadone Rises as a Painkiller With Big Risks  -  Aug 17, 2008
Dr. Howard Heit is a leader in pain management and tightly controls methadone use of patients. Checking pain sensitivity of patient Alexandra Sherman. ... New York Times

Methadone Pioneer Dr. Vincent P. Dole Dies  -  Aug 2, 2006
NEW YORK — Dr. Vincent P. Dole, whose research in the 1960s established that methadone could be used to treat heroin addiction, died Tuesday. He was 93. ... FOXNews

Report flags rise in deaths by methadone ODs  -  Dec 5, 2007
By Donna Leinwand, USA TODAY. Record numbers of people are dying from methadone overdoses as doctors dispense more of the powerful painkiller, according to ... USA Today

Methadone review after boy dies  -  Mar 6, 2006
The first minister has announced a review of Scotland's methadone programme after the death of a toddler who drank the heroin substitute. ... BBC News

Casting Methadone as Ingredient for a Cross-Addiction  -  Oct 6, 2005
By COREY KILGANNON. It seemed like a nodding addict's dream the other day; a group of recovering heroin addicts drank their methadone at a downtown clinic ... New York Times

Methadone Kills Resistant Leukemia Cells  -  Aug 1, 2008
FRIDAY, Aug. 1 (HealthDay News) -- Methadone, a drug used to break addiction to heroin and other opioid drugs, appears to be a potent killer of leukemia ... Washington Post

Deadly abuse of methadone tops other prescription drugs  -  Feb 13, 2007
By Donna Leinwand, USA TODAY. Methadone, a painkiller that has been used to treat heroin addicts for decades, has emerged as an increasingly popular and ... USA Today

Record number of people killed in methadone ODs, report says  -  Dec 6, 2007
By Donna Leinwand. A record number of people are dying from methadone overdoses as doctors dispense more of the powerful painkiller, according to a report ... USA Today

Methadone deaths rising in New England  -  Apr 17, 2008
By Holly Ramer, AP Writer. LACONIA, NH — When her 20-year-old son stumbled home one night last October, Gail DeLucca told him to go to bed and sleep it off. ... USA Today

Goldie lambasts methadone system  -  Nov 14, 2005
The new Scottish Conservative leader Annabel Goldie has used her first major speech to attack the Scottish Executive's drugs strategy. ... BBC News

PROBE AS BOY, 7, TAKES METHADONE IN SCHOOL  -  Jun 15, 2006
The primary two pupil passed out in front of his pals during lessons and spent five days in hospital. It's believed he drank the powerful drug on school ... Scottish Daily Record

Smith's Death Raises Methadone Awareness  -  Feb 15, 2007
By Caitlin A. Johnson. It's unclear what killed Anna Nicole Smith, but methadone was found in her refrigerator. Tracy Smith reports that methadone use is ... CBS News

Methadone 'fails to reduce heroin use or cut crime'  -  Dec 14, 2008
To read this article in full you must have registered and have a Premium Content Subscription with the Scotland On Sunday site. ... Scotland on Sunday

Over 100 methadone clinics set up in past 3 years  -  Mar 27, 2006
WUHAN, Mach 27 (Xinhua) -- China has set up 128 methadone clinics over the past three years since Feb. 2003, when it began the practice of building ... 新�网

Photos of Smith's Refrigerator Reveal Methadone  -  Feb 12, 2007
A photo of the inside of Anna Nicole Smith's refrigerator shows vials of methadone and bottles of diet drinks, according to TMZ.com. ... ABC News

Methadone could be used to kill leukaemia cells  -  Jul 31, 2008
Methadone could be used to kill leukaemia cells resistant to other forms of treatment, according to a new study. By Kate Devlin Medical Correspondent ... Telegraph.co.uk

Birth control call for methadone  -  May 11, 2006
A Labour MSP has called for contraception to be added to methadone to prevent addicts having children. Greenock MSP Duncan McNeil was speaking at Holyrood ... BBC News

King County Jail inmates may get methadone  -  Jul 7, 2005
By Ari Bloomekatz. Linda Drummond remembers the pain she felt withdrawing from heroin addiction while in jail more than 10 years ago. ... Seattle Times

Pathologist: Combination of Methadone, Antidepressants Killed Anna …  -  Dec 11, 2007
AP. The late son of reality TV star Anna Nicole Smith was killed by a combination of methadone and the antidepressants Zoloft and Lexapro — a cocktail that ... FOXNews

The methadone lobby has built a pharmaceutical holding pen that keeps...  -  Oct 3, 2008
This year's award for Least Impressive Interviewee on National Radio goes to Paul Hayes, head of the Government's drugs treatment agency. ... Times Online

Overdose deaths spur methadone warning.  -  Nov 29, 2006
Nov. 29--The US Food and Drug Administration issued a strong advisory this week for methadone, a commonly prescribed pain medicine, warning patients and ... Free with registration - News & Observer - AccessMyLibrary.com

Abbott urges cold turkey for methadone addicts  -  Dec 3, 2005
By Julie Robotham. People who use the heroin substitute methadone will be encouraged to kick their drug addiction completely using a treatment that sends ... The Age

Biometric methadone system for prisons  -  Apr 15, 2008
By Nicole Kobie, 15 Apr 2008 at 17:35. Prisoners addicted to heroin will be able to access methadone prescriptions using a biometric system. ... ITpro - IT PRO

Methadone programme fails 97% of heroin addicts  -  Oct 29, 2006
DRUGS experts have branded Scotland's methadone programme a failure in the wake of a government-funded study that shows only 3% of addicts kick the habit. ... Times Online

Methadone emerges as new killer; Patients and addicts are mixing the ...  -  Feb 26, 2007
A synthetic opiate, methadone is similar to heroin in chemistry, curbing a user's craving for the illegal opiate by blocking the sensors that heroin ... Pay-Per-View - Los Angeles Times - ProQuest Archiver

… : Anna Nicole Smith's Son Died From Combination of Methadone, …  -  Sep 27, 2006
Toxicology tests showed Daniel Smith had methadone, Zoloft and Lexapro in ... Methadone, a pain-reliever, is also commonly used by people recovering from ... FOXNews

9 Middle Schoolers Sickened By Methadone  -  Mar 20, 2008
Backpack ready? Learn more about education in America through fun facts, national statistics and unusual schools. (AP) Nine middle school girls were ... CBS News

Tighter controls urged on methadone 'takeaways'  -  Feb 14, 2005
By Martin Johnston. Supplying drug addicts with "takeaway" doses of methadone is hazardous and should be reviewed, say researchers. ... New Zealand Herald

Mum who killed toddler by dosing him with methadone faces jail  -  Apr 11, 2007
A junky mum who killed her toddler son by feeding him methadone to send him to sleep at night is facing jail. Gemma Fennelly, 24, pleaded guilty to the ... Daily Mail

No trace of methadone in sick boy  -  Jun 20, 2006
A primary school pupil said to have fallen ill after taking methadone did not have the drug in his system, a second hospital test has revealed. ... BBC News

Methadone treatment program proves effective  -  Jan 5, 2008
A Methadone treatment program for drug addicts in China's residential communities is helping to contain drug abuse and prevent AIDS. ... 央视国际

Father jailed for baby's methadone death  -  Jun 7, 2007
By Emma Henry and agencies. A drug addict who killed his baby son after feeding him methadone to quieten him down has been jailed. ... Telegraph.co.uk

… .West Miff Un .Borough Against Methadone Clinic .Similar Objections...  -  Jun 23, 2005
Pittsburgh residents who were unable to stop the same company from opening a clinic off Route 51 in Bon Air lour years ago In both cases. ... Pittsburgh Post-Gazette - Google News Archive

Southern Vietnam uses methadone as drug substitute_English_Xinhua  -  Apr 11, 2008
HANOI, April 11 (Xinhua) -- Vietnam's southern Ho Chi Minh City is using methadone, a synthetic narcotic, as a therapeutic tool to rehabilitate drug addicts ... 新�网

Call for methadone death inquiry  -  Nov 1, 2006
The family of a teenager killed by a drug addict who gave her a cocktail of alcohol and methadone have called for an inquiry into her death. ... BBC News

Addicts who stay clean given extra methadone  -  Oct 19, 2007
By Laura Clout. Cocaine and heroin addicts on a government treatment programme are being offered extra drugs as a reward for good behaviour. ... Telegraph.co.uk

Six-year-old dies of methadone overdose  -  Sep 23, 2005
A six-year-old Sydney girl died of a methadone overdose, apparently because her stepfather kept the drug in a child's cough medicine bottle, according to ... WalesOnline

… than 170,000 drug addicts have received methadone therapy since...  -  Dec 23, 2008
Methadone, a synthesized narcotic developed in Germany in 1937,is far less ... It has been widely recognized that promoting methadone replacement therapy ... 央视国际

Methadone for Addicts Still Under Fire  -  Aug 15, 2006
By DAVID B. CARUSO, AP Writer. NEW YORK — In the late 1960s, a group of black militants paid a visit to a Brooklyn clinic to discuss the new treatment it ... FOXNews

Give heroin addicts heroin, researchers say  -  Jun 3, 2005
Prescribing heroin in addition to the substitute methadone led to a drop in the number of crimes committed by addicts to fund their habit, the study of 430 ... guardian.co.uk

Methadone to be axed for heroin addicts  -  May 25, 2008
The Scottish government will this week unveil plans to phase out methadone treatment for heroin addicts by offering alternative therapies and residential ... Times Online

Police fear over methadone theft  -  Aug 6, 2007
A woman was assaulted and robbed of a potentially lethal quantity of methadone in Swindon. The theft happened in the early hours of Saturday in a field next ... BBC News

Second test rules out methadone in blood of primary schoolboy  -  Jun 21, 2006
A SEVEN-YEAR-OLD who collapsed at school did not have methadone in his body, as first feared, it was confirmed last night. ... Pay-Per-View - Scotsman - Factiva, from Dow Jones

Boulder student died of overdose - Methadone-linked deaths doubled in...  -  Mar 18, 2005
A Colorado University student from Colorado Springs who died at the Boulder campus in November overdosed on methadone, a drug to treat heroin addiction that ... $2.95 - The Gazette - NewsBank

'Action needed' on methadone use  -  Nov 16, 2008
Urgent action needs to be taken over the "escalating" use of the heroin substitute methadone to treat addicts, it has been warned. ... BBC News

Mother's methadone curbs appeal  -  Feb 1, 2007
A mother has called for tougher controls on prescribing methadone after an inquest heard her son died after taking the heroin substitute. ... BBC News

Pill 'alternative' to methadone  -  Dec 8, 2006
A pill that is both cheaper and safer than methadone has been found to be just as effective at treating heroin addicts, a new study has found. ... BBC News

Understand the value of methadone treatment  -  Feb 26, 2005
Krawitz, of Elliston, is a disabled US Air Force veteran and a Virginia Tech undergraduate student of computer engineering on extended medical leave. ... Roanoke Times

Anna Nicole Smith's son Daniel 'intentionally overdosed on methadone'  -  Jan 30, 2008
Anna Nicole Smith's son Daniel intentionally took the methadone believed to be the primary factor in his death, an inquest has heard. ... Daily Mail

Moves to dump methadone thwarted as SNP backs report's endorsement  -  Jul 22, 2007
METHADONE should continue to be the main treatment for addicts in Scotland, but more support needs to be in place to encourage users to become drug-free. ... Sunday Herald

Boy dies after drinking methadone  -  Jun 20, 2006
A three-year-old boy who drank his drug addict mother's methadone died after a "catalogue of catastrophes", a coroner has said. ... BBC News

Vietnam accepts methadone as heroin substitute to control HIV...  -  Jun 16, 2005
Hanoi, 15 June: The Health Ministry has agreed to the use of methadone, a synthetic narcotic, to eventually wean heroin addicts off the drug. ... Free with registration - Asia Africa Intelligence Wire - AccessMyLibrary.com

Methadone: a necessary evil  -  Mar 19, 2008
Methadone can be highly addictive and dangerous and has been linked to the deaths of several drug addicts' children. So why does the NHS pay for it to be ... BBC News

Anna Nicole to Testify in Son`s Inquest  -  Jan 16, 2007
An private autopsy points to a lethal combo of methadone and antidepressants ... Why would she be taking methadone, which is typically used for heroin users ... CNN International

Pharmacist 'gave child methadone'  -  Apr 25, 2006
A pharmacist who is believed to have given an 11-year-old boy the heroin substitute methadone has denied misconduct at a disciplinary hearing. ... BBC News

Two held after toddler's methadone overdose  -  Mar 17, 2008
LONDON (Reuters) - Two men have been arrested after a two-year-old boy died from a suspected overdose of methadone. West Midlands Police said the men, ... Reuters UK

SNP's new policy on drugs drops methadone  -  May 29, 2008
The SNP has switched the emphasis in Scotland's drugs strategy from harm reduction to recovery and rehabilitation. The Scottish government hopes that its ... Times Online

Mother faces murder charge ; Infant died with high levels of methadone...  -  Nov 19, 2005
During her pregnancy, [Gina Camponeschi] used drugs, and [Adriana Jean Richards] was born addicted, according to police, who would not reveal which ... Pay-Per-View - The Sun - ProQuest Archiver

Leap in methadone overdoses prompts police to clamp down  -  Apr 18, 2008
Holly Ramer, AP. (04-18) 04:00 PDT Laconia, NH -- When her 20-year-old son stumbled home one night in October, Gail DeLucca told him to go to bed and sleep ... San Francisco Chronicle

Officials: Anna Nicole probe not closed  -  Sep 28, 2006
He says it was an interaction of methadone and two antidepressants. ... Smith's 20-year-old son died from the accidental effect of methadone and two ... msnbc.com

Methadone 'mix-up' killed daughter  -  Jan 23, 2008
..."I LOVE you, big jelly bean," six-year-old Rose Villanueva-Austin allegedly said to her mother. It was 3am, she was feeling unwell, and her mother, ... Sydney Morning Herald

Baby methadone death trial halted  -  Oct 31, 2006
The trial of two heroin addicts accused of killing their baby son with an overdose of methadone has been halted. Mark Bate, 33, and 23-year-old partner ... BBC News

Inmates 'overdose on methadone'  -  May 27, 2006
Seven inmates were treated in hospital for a suspected drug overdose after an incident at Edinburgh's Saughton Prison on Friday evening. ... BBC News

Mother found not guilty of girl's methadone death  -  Feb 15, 2008
..."I had to have her back" ... Julie-Anne Austin yesterday with a tattoo of her daughter, Rose Villanueva-Austin. IT WAS an accident waiting to happen. ... Sydney Morning Herald

3000 Lothians heroin addicts take lethal methadone home  -  Mar 11, 2006
By JANE BRADLEY AND STEWART COOPER. AROUND 3000 heroin addicts are regularly allowed to take methadone home with them in the Lothians despite fears of ... Scotsman

Normal doses of methadone may trigger sudden death  -  Jan 23, 2008
NEW YORK (Reuters Health) - A number of cases of unexplained sudden cardiac death can be blamed on taking regular "therapeutic" doses of methadone, ... Reuters India

Methadone pipeline shut down  -  Feb 25, 2006
A husband-and-wife team of pharmacists has been ordered to shut down a controversial methadone pipeline servicing 2000 drug addicts across Ontario. ... Toronto Star

Methadone syringe 'used for cough syrup'  -  Feb 6, 2008
By Amy Coopes. THE de facto husband of a woman accused of fatally dosing her daughter with methadone has said he used the same syringe to give cough syrup ... NEWS.com.au

MDs profit from methadone scheme  -  Mar 4, 2006
Dr. Jeff Daiter, co-founder of the Ontario Addiction Treatment Centres, arrives at his office in Richmond Hill. Doctors at a large chain of methadone ... Toronto Star

EXCLUSIVE; Dig truckers wheel in to methadone clinic  -  Sep 7, 2005
Big Dig workers are lining up at the crack of dawn to get heroin- weaning methadone from a local clinic - including some who operate heavy equipment, ... Pay-Per-View - Boston Herald - ProQuest Archiver

Dead child given methadone 'by mistake'  -  May 24, 2007
A SYDNEY woman's claim that she accidentally mixed up bottles of children's medicine and methadone, killing a six-year-old child, has been challenged in ... Sydney Morning Herald

Methadone patients should be served one at a time: inquest  -  Nov 3, 2006
Patients at Ontario methadone clinics should be served one at a time to reduce the risk of mistakenly receiving someone else's dose, a coroner's inquest ... CBC.ca

West Allis man accused of reckless homicide in methadone death.  -  Apr 7, 2006
Apr. 7--Waukesha -- For the second time in four months, Waukesha County prosecutors have invoked the state's seldom-used Len Bias law to file a homicide ... Free with registration - Milwaukee Journal Sentinel - AccessMyLibrary.com

Methadone sickens students; Forsyth family charged | ajc.com  -  Oct 23, 2008
By NANCY BADERTSCHER. Two Forsyth County parents are facing felony drug charges over an incident earlier this month in which three high school boys became ... Atlanta Journal Constitution

Methadone: One Pill Can Kill  -  Sep 22, 2006
By JIM AVILA and BONNIE VANGILDER. Pain pills are the new "pocket gold" on the street, so valuable to drug dealers that the neighborhood prescription ... ABC News

Methadone prescriptions to addicts double in two years, say Tories  -  Dec 22, 2008
Doctors are prescribing more than twice as much of the heroine substitute methadone to drug addicts as they did two years ago, official figures show. ... Telegraph.co.uk

… turns sadness into a fight to rid streets of methadone - The...  -  Jan 12, 2008
Fatal methadone overdoses in Massachusetts have risen more than 400 percent in ... New Hampshire health officials have seen a similar increase in methadone ... Boston Globe

Company wants to take methadone to Brattleboro and Springfield  -  Apr 13, 2006
BRATTLEBORO, Vt. --The company that runs mobile methadone programs in the Northeast Kingdom wants to open mobile clinics in Brattleboro and Springfield. ... Boston Globe

Methadone-related deaths surpass traffic deaths in NH  -  Mar 16, 2008
CONCORD, NH—More people are dying of drug overdoses in New Hampshire than in car crashes, with methadone the leading cause of death in most of the cases. ... Boston Globe

Surprising Kids Killer: Methadone  -  Apr 10, 2006
By Brian Dakss. A painkiller rarely mentioned in drug warnings for kids is now the No. 1 drug that kills young people in several states. ... CBS News

Methadone clinic official gets mixed review in Conway, NH  -  May 1, 2008
CONWAY, NH—Many Conway officials and residents are up in arms over a proposal to open a methadone clinic that many say would attract drug users to the ... Boston Globe

Clinic advised methadone overdose victim to go to hospital, witness …  -  Oct 30, 2006
Shortly after drinking a massive overdose of methadone at an Ottawa drug treatment centre, Wade Hatt was advised by a doctor at the clinic to go to a ... Canada.com

Drug Raids Follow Wake of Anna Nicole Overdose Death  -  Oct 14, 2007
Methadone is a popular narcotic painkiller that is used as part of drug ... Methadone overdoses can cause shallow breathing and dangerous changes in ... Hollywood Today Newsmagazine

Methadone, alcohol bad mix, inquest hears  -  Jan 24, 2008
Testifying at a coroner's inquest about the death of a prisoner in the Saskatoon police holding cells is not a new experience for Bill Watt, ... Canada.com

Tory MSP Labels Methadone Users As 'Fat, Dumb & Happy'  -  Mar 17, 2008
The party's justice spokesman Bill Aitken made the claim as he called for more schemes to get users off the heroin substitute. ... Scottish Daily Record

Labour MSP defends call to put Pill in addicts' methadone  -  May 13, 2006
By RHIANNON EDWARD. A LABOUR MSP yesterday defended his call for contraceptives to be put in methadone as a method of stopping drug-addicted women becoming ... Scotsman

HSE urges resumption of methadone services  -  Oct 15, 2007
Members of the Irish Pharmaceutical Union have withdrawn services to methadone patients in a row over a new drug payment structure. ... RTE.ie

Methadone clinic nurse did not know overdose procedure, inquest told  -  Oct 31, 2006
An Ottawa clinic nurse who first noticed a man had received a fatal methadone overdose during treatment told a coroner's inquest that she did not know of ... CBC.ca

METHADONE GETS A HARD LOOK AFTER OVERDOSES - USED TO …  -  Jul 13, 2008
USED TO TREAT PAIN AND HELP HEROIN ADDICTS, THE DRUG IS NOW BLAMED ON A GROWING NUMBER OF DEATHS. Methadone, long prescribed as an alternative to heroin, ... $2.95 - Charlotte Observer - NewsBank

'Methadone mum' committed for trial  -  May 24, 2007
A WOMAN accused of killing her six-year-old daughter with fatal dose of methadone has been committed to stand trial for murder, despite key forensic ... The Australian

Methadone doses delivered; Kitchener drugstore told to halt distributi...  -  Mar 14, 2006
...[Jeff Daiter] didn't provide details but said an agreement between the Ontario College of Pharmacists, the College of Physicians and Surgeons of Ontario and ... Pay-Per-View - The Record - ProQuest Archiver

Budget cuts may seal fate of methadone clinic in SJ  -  Jun 6, 2006
Jun. 6--STOCKTON -- San Joaquin County's only publicly operated methadone clinic could close in September under a plan being reviewed by local lawmakers ... Free with registration - The Record - AccessMyLibrary.com

In Camden, clinic plan draws protest - Methadone center should remain...  -  Sep 28, 2008
Methadone center should remain at its current location, not move to city's port, critics say. Opponents of a proposed methadone clinic at Camden's South ... $2.95 - Philadelphia Inquirer - NewsBank

Woman jailed for baby's methadone death  -  Apr 5, 2007
Article from: Australian AP. A SYDNEY woman who killed her baby son by giving him methadone could be released from jail in just over a year. ... The Australian

Methadone mother walks free  -  Feb 14, 2008
A Sydney woman accused of killing her six-year-old daughter by deliberately giving her methadone has walked free from a Sydney court. ... Brisbane Times

Deal reached in methadone case  -  Feb 24, 2007
A deal has been reached between a pharmacist accused of professional misconduct and prosecutors with the Ontario College of Pharmacists. ... Toronto Star

Methadone clinic faces sanctions  -  Dec 20, 2008
By ANNETTE WELLS. The Nevada Bureau of Health Care Quality and Compliance has warned a Las Vegas methadone clinic that it intends to sanction the facility ... Las Vegas Review-Journal - Las Vegas Review - Journal

Acute methadone intoxication blamed for deaths of teens at Tahoe  -  Oct 23, 2006
AP. ZEPHYR COVE, Nev. – Two Douglas County teenagers whose bodies were found July 22 at Lake Tahoe died of acute methadone intoxication, sheriff's deputies ... San Diego Union - Tribune - San Diego Union Tribune

Toddler dies after drinking methadone  -  Jun 29, 2007
CHICAGO, June 29 (UPI) -- A Chicago mother has been charged with the death of her 2-year-old son after he drank her methadone prescription. ... United Press International

Methadone enantiomer plasma levels, CYP2B6, CYP2C19, and CYP2C9 …  -  Apr 29, 2005
Correspondence: Chin B. Eap, PhD, Hôpital de Cery, CH-1008 Prilly-Lausanne, Switzerland E-mail: Chin.Eap@chuv.ch. * This work was supported by the Swiss ... Nature.com

Brand Names/Synonyms:
Methadone is also known by the following brand names and/or synonymsAdanon; Adanon hydrochloride; Adolan; Algidon; Algolysin; Algovetin; Althose hydrochloride; Amidon; Amidone; Biscuits; Butalgin; CCRIS 3320; DL-Methadone hydrochloride; DRG-0023; Depridol; Diaminon; Diaminon hydrochloride; Dollies; Dolly; Dolofin hydrochloride; Dolohepton; Dolophin; Dolophin hydrochloride; Dolophine; Dolophine HCL; Fenadon; Fenadone; Heptadon; Heptadone; Heptanon; Ketalgin; Ketalgin hydrochloride; Mecodin; Medicine; Mephenon; Meth; Methadon; Methadone; Methadone HCL; Methadone HCL Intensol; Methadone M; Methadone hydrochloride; Methadone hydrochloride dl-; Methadose; Methaquaione; Miadone; Moheptan; Phenadone; Phenadone hydrochloride; Physeptone; Polamidon; Polamidone; Racemic methadone; Racemic methadone hydrochloride; Tussol:; Westadone; dl-Methadone; (+/-)-Methadone; (+/-)-Methadone hydrochloride; (+/-)-Tussal

Drug Category:
Methadone is categorized under the following by the FDA: Narcotics; Antitussives; Analgesics; Opiate Agonists; ATC:N02AC52; ATC:N07BC02; ATC:R05DA06

Dosage Forms:
TABLET

Absorption:
Not Available

Interactions:
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Chemical IUPAC Name:
6-dimethylamino-4,4-diphenyl-heptan-3-one





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