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MethadoseThis page contains recent news articles, when available, and an overview of Methadose but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.Overview: Methadose (when available) Methadone is a synthetic opioid analgesic with multiple actions quantitatively similar to those at morphine, the most prominent of which involve the central nervous system and organs composed of smooth muscle. However, Methadone is more active and more toxic than morphine. Methadone is indicated for relief of severe pain, for detoxification treatment of narcotic addiction, and for temporary maintenance treatment of narcotic addiction. The principal actions of therapeutic value are analgesia and sedation and detoxification or temporary maintenance in narcotic addiction. The Methadone abstinence syndrome, although qualitatively similar to that of morphine, differs in that the onset is slower, the course is more prolonged, and the symptoms are less severe. For the treatment of dry cough, drug withdrawal syndrome, opioid type drug dependence,pain Mechanism Of Action: Opiate receptors are coupled with G-protein receptors and function as both positive and negative regulators of synaptic transmission via G-proteins that activate effector proteins. Binding of the opiate stimulates the exchange of GTP for GDP on the G-protein complex. As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine and noradrenaline is inhibited. Opioids also inhibit the release of vasopressin, somatostatin, insulin and glucagon. Methadone's analgesic activity is, most likely, due to its conversion to morphine. Opioids close N-type voltage-operated calcium channels (OP2-receptor agonist) and open calcium-dependent inwardly rectifying potassium channels (OP3 and OP1 receptor agonist). This results in hyperpolarization and reduced neuronal excitability. Methadone has a unique affinity for the NMDA brain receptor. It is believed that NMDA (N-methyl-D-aspartic acid) may regulate psychic dependence and tolerance by exhibiting opioid antagonist-like activity. News Articles on Methadone FDA Has New Web Page for Select Medicine Disposal Instructions - Oct 20, 2009 Methadone Hydrochloride, Methadose, Morphine Sulfate, MS Contin, Onsolis, Opana, Opana ER, Oramorph SR, Oxycontin, Percocet, Percodan, and Xyrem. ... DOTmed.com (press release) Taylor:2 charged in botched ATM theft - Jan 27, 2009 A patient identified only as SAS died in 2004 from an overdose of Methadose, a pain reliever similar to morphine. Assistant US Attorney Ronald Waterstreet DetNews.com, Deal likely for Mich. doctor linked to 2 deaths - Jan 23, 2009 The indictment says a drug called Methadose led to the deaths of two people in 2004 and 2005. Messages seeking comment were left with Emerson, Chicago Tribune, Ex-area doctor pleads guilty to causing death - Jan 28, 2009 In the Emerson case, a patient identified only as SAS died in 2004 from an overdose of Methadose, a pain reliever similar to morphine. Monroenews.com, For the record - Jan 25, 2009 Stephanie L. Robinson, 25, 1210 S. Ninth St., Manitowoc, deliver methadose, probation revoked, one year in prison, three years of extended supervision Herald Times Reporter, Feds: Pot growing at retired officer's home - Jan 24, 2009 The indictment says a drug called Methadose led to the deaths of two people in 2004 and 2005. GRAND RAPIDS - A former Steelcase Inc. employee who secretly Lansing State Journal, Detroit-area doctor pleads guilty to causing death - Jan 27, 2009 By ED WHITE AP DETROIT (AP) — A suburban Detroit doctor has pleaded guilty to causing the death of a patient though the illegal distribution of prescription MLive.com, CDC studies trend of painkiller overdose - Dec 9, 2008 Methadone or Methadose, Dr. Aron Hall of the Centers for Disease Control said. The CDC studied the trend, with a focus on West Virginia. WRAL.com, Physician charged in multi-state prescription drug ring - Nov 3, 2008 Sievers faces up to 20 years in prison on a conspiracy charge and was also indicted on five counts of illegally distributing methadose and one count of Lebanon Western Star, Doctor facing charges - Nov 6, 2008 ...hydrocodone (Vicodin), oxycodone (Percocet or OxyContin), and methadone (Methadose 40mg.). Many of these drugs were allegedly then sold on the streets, Times Community Newspapers of Greater Dayton, 2 are arrested in Detroit drug raid - Apr 4, 2008 The pills deputies found at his home then -- among them were Vicodin, Xanax, Methadose, Seroque and Soma -- were analyzed, and formed the basis of the Detroit Free Press, 'Dr. Pill' arrested in drug raid - Apr 3, 2008 Deputies had raided the brick home in January and seized $200000 in cash as well as about 1000 pills, including painkillers like Vicodin, Methadose and Soma DetNews.com, Brand Names/Synonyms: Methadose is also known by the following brand names and/or synonyms: Adanon; Adanon hydrochloride; Adolan; Algidon; Algolysin; Algovetin; Althose hydrochloride; Amidon; Amidone; Biscuits; Butalgin; CCRIS 3320; DL-Methadone hydrochloride; DRG-0023; Depridol; Diaminon; Diaminon hydrochloride; Dollies; Dolly; Dolofin hydrochloride; Dolohepton; Dolophin; Dolophin hydrochloride; Dolophine; Dolophine HCL; Fenadon; Fenadone; Heptadon; Heptadone; Heptanon; Ketalgin; Ketalgin hydrochloride; Mecodin; Medicine; Mephenon; Meth; Methadon; Methadone; Methadone HCL; Methadone HCL Intensol; Methadone M; Methadone hydrochloride; Methadone hydrochloride dl-; Methadose; Methaquaione; Miadone; Moheptan; Phenadone; Phenadone hydrochloride; Physeptone; Polamidon; Polamidone; Racemic methadone; Racemic methadone hydrochloride; Tussol:; Westadone; dl-Methadone; (+/-)-Methadone; (+/-)-Methadone hydrochloride; (+/-)-Tussal Drug Category: Methadose is categorized under the following by the FDA: Narcotics; Antitussives; Analgesics; Opiate Agonists; ATC:N02AC52; ATC:N07BC02; ATC:R05DA06 Dosage Forms: TABLET Absorption: Not Available Interactions: [an error occurred while processing this directive] Chemical IUPAC Name: 6-dimethylamino-4,4-diphenyl-heptan-3-one |
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