Methylergonovine

This page contains recent news articles, when available, and an overview of Methylergonovine but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Methylergonovine
(when available)

Pharmacology and use:
Methylergonovine is a semisynthetic ergot alkaloid and a derivative of ergonovine and is used for the prevention and control of postpartum and post-abortion hemorrhage. In general, the effects of all the ergot alkaloids appear to results from their actions as partial agonists or antagonists at adrenergic, dopaminergic, and tryptaminergic receptors. The spectrum of effects depends on the agent, dosage, species, tissue, and experimental or physiological conditions. All of the alkaloids of ergot significantly increase the motor activity of the uterus. After small doses contractions are increased in force or frequency, or both, but are followed by a normal degree of relaxation. As the dose is increased, contractions become more forceful and prolonged, resting tonus is markedly increased, and sustained contracture can result. For the prevention and control of excessive bleeding following vaginal childbirth

Mechanism Of Action:
Methylergonovine acts directly on the smooth muscle of the uterus and increases the tone, rate, and amplitude of rhythmic contractions through binding and the resultant antagonism of the dopamine D1 receptor. Thus, it induces a rapid and sustained tetanic uterotonic effect which shortens the third stage of labor and reduces blood loss.

News Articles on Methylergonovine

Efficacy and tolerability of intravenous methylergonovine in migraine female ...  -  ‎Nov 8, 2009‎
Methylergonovine is an ergot alkaloid widely used in postpartum women. It is also an active metabolite of methysergide and previous studies suggest that it ... 7thSpace Interactive (press release)

FDA Approves Labeling Update for REYATAZ® (atazanavir sulfate) Capsules to ...  -  ‎Nov 5, 2009‎
...ergonovine, methylergonovine, cisapride, St. John's wort (Hypericum perforatum)-containing products, lovastatin, simvastatin, pimozide, or indinavir. ... WELT ONLINE

Christ Hospital Nurse, Pharmacist Collaborate to Ensure Patient Safety  -  ‎Oct 19, 2009‎
Esposito was concerned because both generic drugs — Oxytocin and Methylergonovine — are routinely prescribed for obstetrical patients. ... Nurse.com

Active Management of Third Stage of Labour May Increase Total Oxytocin ...  -  ‎Oct 22, 2009‎
Parameters included the amount of oxytocin infused after delivery, administration of supplemental uterotonics (eg, methylergonovine, prostaglandin 15-methyl ... DG News

… vasospasm Ergonovine Uterine stimulant Ergonovine Methylergonovine...  -  Feb 1, 2006
Ergonovine and methylergonovine belong to the group of medicines known as ergot ... Ergonovine and methylergonovine may also be used for other conditions as ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Prevention and management of postpartum hemorrhage.(Disease/ …  -  Mar 15, 2007
Methylergonovine (Methergine) and ergometrine (not available in the United States) are ... (32) A typical dose of methylergonovine, 0.2 mg administered ... Free with registration - American Family Physician - AccessMyLibrary.com

Oregon Regulations - 332-025-0040 Approved Legend Drugs For …  -  Aug 9, 2005
...(3) Anti-Hemorrhagics for oral administration is limited to: (a) Methylergonovine (Methergine); (b) Misoprostol (Cytotec). (4) Anti-Hemorrhagics for rectal ... Pay-Per-View - Oregon Regulations - Loislaw

Prevention and management of postpartum hemorrhage.(Disease/ …  -  Mar 15, 2007
Methylergonovine (Methergine) and ergometrine (not available in the United States) are ... (32) A typical dose of methylergonovine, 0.2 mg administered ... $4.95 - American Family Physician - ECNext

New Abbott Aluvia® Tablet for Treatment of HIV Available in South...  -  Jun 2, 2008
Do not take Aluvia with astemizole, terfenadine, midazolam, triazolam, pimozide, cisapride, ergotamine, dihydroergotamine, ergonovine, methylergonovine, ... AllAfrica.com

PREZISTA Receives US FDA Approval as Part of HIV Combination …  -  Jun 23, 2006
PREZISTA/rtv is contraindicated with astemizole, terfenadine, dihydroergotamine, ergonovine, ergotamine, methylergonovine, cisapride, pimozide, midazolam, ... Free with registration - PR Newswire - AccessMyLibrary.com

Abbott Statement on Agreement With Brazilian Government for Kaletra(R)...  -  Jul 11, 2005
Kaletra should not be taken with astemizole, cisapride, dihydroergotamine, ergonovine, ergotamine, methylergonovine, midazolam, pimozide, terfenadine or ... Medical News Today - Medical News Today (press release)

Abbott Agrees With World Health Organization (WHO) Director-General...  -  Apr 10, 2007
...ergotamine, dihydroergotamine, ergonovine and methylergonovine), products containing St. John's wort (Hypericum perforatum) and vardenafil. ... Free with registration - PR Newswire - AccessMyLibrary.com

Abbott在å?—é?žæ??出抗HIVæ–°è?¯ç‰‡å‰‚注册申请  -  Apr 5, 2006
Lopinavir/ritonavir�应与astemizole�cisapride�dihydroergotamine�ergonovine �ergotamine�methylergonovine�midazolam�pimozide�terfenadine或triazolam一� ... ��

Abbott Study Shows Investigational Heat-Stable Norvir(R) Tablet...  -  Aug 8, 2008
Norvir must not be taken with Cordarone(R) (amiodarone); ergotamine, ergonovine, methylergonovine, and dihydroergotamines such as Cafergot(R); Migranal(R); ... presseportal.de

雅培通过FDA 对其新的低浓度Kaletra(洛匹那韦ï¼?利托那韦)è?¯ç‰‡æ²»ç–—å„¿ç«¥ …  -  Nov 13, 2007
...maleate 和methergine 等甲麦角新碱(methylergonovine) �时�用,也�得与Halcion(R)( 三唑仑(triazolam))�Orap(R)(哌咪清(pimozide))�Propulsid(R)(西沙必 ... 金�界

Abbott Receives FDA Approval for New Kaletra(R) (Lopinavir/Ritonavir)...  -  Oct 31, 2005
Kaletra should not be taken with dihydro.ergotamine, ergonovine, ergotamine, and methylergonovine such as Cafergot(R), Migranal(R), DHE 45(R), ... Free with registration - PR Newswire - AccessMyLibrary.com

Abbott's New Tablet Formulation of Kaletra(R) (lopinavir/ritonavir) …  -  Jul 3, 2006
Kaletra should not be taken with amiodarone, astemizole, cisapride, dihydroergotamine, ergonovine, ergotamine, methylergonovine, midazolam, pimozide, ... Free with registration - PR Newswire - AccessMyLibrary.com

Tibotec Therapeutics Launches New Dosage Strength for PREZISTA(TM)  -  May 19, 2008
...dihydroergotamine, ergonovine, ergotamine, methylergonovine, cisapride, pimozide, midazolam, or triazolam) and for which elevated plasma concentrations ... RedOrbit

Abbott Statement on Agreement With Brazilian Government for Kaletra(R)...  -  Jul 12, 2005
Kaletra should not be taken with astemizole, cisapride, dihydroergotamine, ergonovine, ergotamine, methylergonovine, midazolam, pimozide, terfenadine or ... i-newswire.com

Nicole Kidman Terima "Order of Australia"  -  Apr 10, 2007
...ergotamine, dihydroergotamine, ergonovine dan methylergonovine) produk yang berisikan “wort St John� (Hypericum perforatum) dan vardenafil. ... ANTARA

Tibotec Therapeutics Announces Initiation of the Largest US Clinical ...  -  Sep 28, 2006
...dihydroergotamine, ergonovine, ergotamine, methylergonovine, cisapride, pimozide, midazolam, or triazolam) and for which elevated plasma concentrations ... Free with registration - PR Newswire - AccessMyLibrary.com

Long-Term Study Evaluates Boosted PREZISTA(R) Vs. Lopinavir/ …  -  Oct 28, 2008
...dihydroergotamine, ergonovine, ergotamine, methylergonovine, cisapride, pimozide, oral midazolam, triazolam, lovastatin, or simvastatin). ... Medical News Today - Medical News Today (press release)

New Data Show a Kaletra(R) (Lopinavir/Ritonavir)-Based Regimen …  -  Nov 18, 2005
Kaletra should not be taken with astemizole, cisapride, dihydroergotamine, ergonovine, ergotamine, methylergonovine, midazolam, pimozide, terfenadine or ... biotech-intelligence.com

New Abbott Aluvia(R) Tablet for Treatment of HIV Available in South …  -  Mar 6, 2008
Do not take Aluvia with astemizole, terfenadine, midazolam, triazolam, pimozide, cisapride, ergotamine, dihydroergotamine, ergonovine, methylergonovine, ... ITNews

Abbott Submits EU and US Regulatory Filings for New Lower-Strength …  -  Jul 20, 2007
Do not take Kaletra with astemizole, terfenadine, midazolam, triazolam, pimozide, cisapride, ergotamine, dihydroergotamine, ergonovine, and methylergonovine ... Free with registration - PR Newswire - AccessMyLibrary.com

Abbott's New Tablet Formulation Of Kaletra(R) (Lopinavir/Ritonavir) …  -  Apr 30, 2006
Kaletra should not be taken with astemizole, cisapride, dihydroergotamine, ergonovine, ergotamine, methylergonovine, midazolam, pimozide, terfenadine or ... Medical News Today - Medical News Today (press release)

=> Abbott Statement on Agreement With Brazilian Government for...  -  Sep 7, 2005
Kaletra should not be taken with astemizole, cisapride, dihydroergotamine, ergonovine, ergotamine, methylergonovine, midazolam, pimozide, terfenadine or ... FinanzNachrichten.de

Boehringer Ingelheim Initiates SPRING Study of Aptivus(R) (tipranavir)...  -  Jun 14, 2007
...ergonovine, ergotamine, methylergonovine, cisapride, pimozide, midazolam, or triazolam due to the potential for serious and/or life-threatening events. ... Free with registration - PR Newswire - AccessMyLibrary.com

Analysis Provides Additional Data For PREZISTA As Part Of HIV …  -  Aug 15, 2006
PREZISTA/rtv is contraindicated with astemizole, terfenadine, dihydroergotamine, ergonovine, ergotamine, methylergonovine, cisapride, pimozide, midazolam, ... Medical News Today - Medical News Today (press release)

Saquinavir (Systemic).  -  Jul 28, 2005
Propulsid) or Ergot medicines (dihydroergotamine [eg, DHE 45], ergoloid mesylates [eg, Hydergine], ergotamine [eg, Ergotrate], methylergonovine [eg, ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

A press release distributed by PR Newswire Europe  -  Apr 4, 2006
Lopinavir/ritonavir should not be taken with astemizole, cisapride, dihydroergotamine, ergonovine, ergotamine, methylergonovine, midazolam, pimozide, ... prnewswire.co.uk

Supplemental New Drug Application For PREZISTAâ„¢ Submitted To US …  -  Dec 25, 2007
...dihydroergotamine, ergonovine, ergotamine, methylergonovine, cisapride, pimozide, midazolam, or triazolam) and for which elevated plasma concentrations ... Medical News Today - Medical News Today (press release)

How to take Minocycline Oral from Consumer Reports Health.  -  Jan 10, 2005
...ergoloid mesylates (Germinal, Hydergine), ergonovine (Ergotrate), ergotamine (Bellergal-S, Cafergot, Ergomar, Wigraine), methylergonovine (Methergine), ... consumerreports.org

African-American Women Who Have Received HIV Treatment Are Sought …  -  Feb 7, 2007
...dihydroergotamine, ergonovine, ergotamine, methylergonovine, cisapride, pimozide, midazolam, or triazolam) and for which elevated plasma concentrations ... Medical News Today - Medical News Today (press release)

Delavirdine (Systemic).(Drug overview)  -  Aug 1, 2006
DHE 45) or Ergonovine (eg, Ergotrate) or Ergotamine (eg, Gynergen) or Lovastatin (eg, Mevacor) or Methylergonovine (eg, Methergine) or Midazolam (eg, ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Abbott Submits Application To EMEA For A New, More Convenient …  -  Jul 31, 2005
Kaletra should not be taken with astemizole, cisapride, dihydroergotamine, ergonovine, ergotamine, methylergonovine, midazolam, pimozide, terfenadine or ... i-newswire.com

Ugandan Children Are Among the First to Receive Abbott's Lower- …  -  Dec 1, 2007
Do not take Kaletra with astemizole, terfenadine, midazolam, triazolam, pimozide, cisapride, ergotamine, dihydroergotamine, ergonovine, and methylergonovine ... Free with registration - PR Newswire - AccessMyLibrary.com

Headache Medicines, Ergot Derivative-Containing ( Systemic).  -  Oct 27, 2005
Cocaine or Epinephrine by injection [eg, Epi-Pen] or Other ergot medicines (ergoloid mesylates [eg, Hydergine], ergonovine [eg, Ergotrate], methylergonovine ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Abbott Statement Regarding New Initiatives To Expand Access And …  -  Aug 20, 2006
...cisapride, midazolam, pimozide, terfenadine, triazolam and ergot alkaloids (eg, ergotamine, dihydroergotamine, ergonovine and methylergonovine). ... Medical News Today - Medical News Today (press release)

Homeopathy Prevents Serious Childbirth Complication  -  Nov 17, 2005
Drugs that help the uterus to contract, such as oxytocin or methylergonovine (Methergine), may be given following delivery to prevent PPH. ... Medfinds

Bromocriptine (Systemic).  -  Feb 1, 2006
Ergot alkaloids (dihydroergotamine [eg, DHE 45], ergoloid mesylates [eg, Hydergine], ergonovine [eg, Ergotrate], ergotamine [eg, Gynergen], methylergonovine ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Boehringer Ingelheim Initiates SPRING Study Of Aptivus(R) (tipranavir)...  -  Jun 15, 2007
...ergonovine, ergotamine, methylergonovine, cisapride, pimozide, midazolam, or triazolam due to the potential for serious and/or life-threatening events. ... Medical News Today - Medical News Today (press release)

Analysis Provides Additional Data For PREZISTA(R) (Darunavir) As Part...  -  Aug 20, 2006
PREZISTA/rtv is contraindicated with astemizole, terfenadine, dihydroergotamine, ergonovine, ergotamine, methylergonovine, cisapride, pimozide, ... Medical News Today - Medical News Today (press release)

Lopinavir/ritonavir tablets  -  Nov 1, 2005
...dihydroergotamine, ergonovine, ergotamine, methylergonovine, cisapride, St John's wort, lovastatin, simvastatin, pimozide, midazolam, and triazolam. ... Free with registration - Formulary - AccessMyLibrary.com

Clinical Quiz.(family medicine)  -  Mar 15, 2007
B. Methylergonovine (Methergine). [] C. Carboprost (Hemabate). [] D. Misoprostol. Type X Questions Each question has one or more correct answers. ... Free with registration - American Family Physician - AccessMyLibrary.com

Ritonavir (Systemic).  -  Feb 1, 2006
Wigraine) or Flecainide (eg, Tambocor) or Lovastatin (eg, Mevacor) or Methylergonovine (eg, Methergine) or Midazolam (eg, Versed) or Pimozide (eg, ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Saquinavir (Systemic).(Drug overview)  -  May 1, 2006
Propulsid) or Ergot medicines (dihydroergotamine [eg, DHE 45], ergoloid mesylates [eg, Hydergine], ergotamine [eg, Ergotrate], methylergonovine [eg, ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

A review of the new antifungals: posaconazole, micafungin, and …  -  Dec 1, 2007
Ercaf[R] Wigraine[R], dihydroergotamine (D.H.E. 45[R] Migranal[R] Nasal Spray), ergonovine (Ergotrate[R], and methylergonovine (Methergine[R]). ... $4.95 - Journal of Drugs in Dermatology - ECNext

Montana Administrative Rules - 24.111.511 NATUROPATHIC …  -  Aug 9, 2005
...and (ii) pseudoephedrine; (g) ergot: (i) ergonovine; (ii) ergotamine tartrate; and (iii) methylergonovine; (h) glycerrhiza (licorice); (i) hydrocodone; ... Pay-Per-View - Montana Administrative Rules - Loislaw

Bromocriptine (Systemic).(Drug overview)  -  May 1, 2006
Ergot alkaloids (dihydroergotamine [eg, DHE 45], ergoloid mesylates [eg, Hydergine], ergonovine [eg, Ergotrate], ergotamine [eg, Gynergen], methylergonovine ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Abbott's New Tablet Formulation of Kaletra'R', Lopinavir/Ritonavir, …  -  Sep 12, 2006
Kaletra should not be taken with astemizole, cisapride, dihydroergotamine, ergonovine, ergotamine, methylergonovine, midazolam, pimozide, terfenadine or ... marketwire.com

This antiviral offers new option to HIV patients.(NEW DRUG)  -  Aug 7, 2006
Use of Prezista is contraindicated with astemizole, terfenadine, dihydroergotamine, ergonovine, ergotamine, methylergonovine, cisapride, pimozide, ... Free with registration - Drug Topics - AccessMyLibrary.com

Dihydroergotamine (Nasal-Systemic).(Drug overview)  -  May 1, 2006
Cocaine or Epinephrine by injection [eg, Epi-Pen] or Other ergot medicines (ergoloid mesylates [eg, Hydergine], ergonovine [eg, Ergotrate], methylergonovine ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Eletriptan (Systemic).(Drug overview)  -  Aug 1, 2006
DHE 45, Migranal], ergoloid mesylates [eg, Hydergine], ergonovine [eg, Ergotrate], ergotamine [eg, Bellergal, Cafergot, Wigraine], methylergonovine [eg, ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Abbott Statement on Advancing Pediatric HIV Treatment in Developing …  -  Mar 13, 2006
Lopinavir/ritonavir should not be taken with dihydroergotamine, ergonovine, ergotamine, and methylergonovine such as Cafergot(R), Migranal(R), DHE 45(R), ... $4.95 - PR Newswire - ECNext

New Jersey Administrative Code - 10:58A-4.3 HCPCS procedure codes …  -  Aug 16, 2005
...(Mepergan), up to 50 mg J2210 Injection, methylergonovine maleate, 3.74 (Metherqine Maleate), up to 0.2 mg J2250 Injection, midazolam hydrochloride, ... Pay-Per-View - New Jersey Administrative Code - Loislaw

COMUNICADO: Los niños de Uganda se encuentran entre los primeros …  -  Dec 1, 2007
...dihydroergotamine, ergonovine, y methylergonovine, rifampicin, amiodarone, vardenafil y productos que contengan St. John's Wort (Hypericum perforatum). ... elEconomista.es

ABBOTT STATEMENT ON ADVANCING PEDIATRIC HIV TREATMENT.  -  Mar 14, 2006
Lopinavir/ritonavir should not be taken with dihydroergotamine, ergonovine, ergotamine, and methylergonovine such as Cafergot(R), Migranal(R), DHE 45(R), ... $4.95 - AsiaPulse News - ECNext

Washington Administrative Code - WAC 246-834-250 (1) Licensed …  -  Mar 17, 2006
...such as misoprostel per rectum (for use only in postpartum hemorrhage), methylergonovine maleate in the absence of hypertension, oral or intramuscular, ... Pay-Per-View - Washington Administrative Code - Loislaw

Oregon Regulations - 850-060-0225 Naturopathic Formulary …  -  Feb 1, 2006
...(236) Methoxsalen; (237) Methscopolamine; (238) Methylergonovine; (239) Methylprednisolone; (240) Methylsulfonylmethane (MSM); (241) Methyltestosterone; ... Pay-Per-View - Oregon Regulations - Loislaw

Prezista: darunavir tablets.(New molecular entities/biologics)  -  Aug 1, 2006
...including: astemizole, terfenadine, dihydroergotamine, ergonovine, ergotamine, methylergonovine, cisapride, pimozide, midazolam, and triazolam. ... $4.95 - Formulary - ECNext

LABORATORIOS ABBOTT ESTABLECE ACUERDO CON GOBIERNO …  -  Jul 12, 2005
Kaletra no debe tomarse junto con astemizole, cisapride, dihydroergotamine, ergonovine, ergotamine, methylergonovine, midazolam, pimozide, terfenadine o ... Peruprensa.org

Georgia Code - 16-13-71. (a) A "dangerous drug" means any drug other ...  -  Aug 4, 2005
...(601) Methyldopa; (602) Methyldopate; (603) Methylene blue, Oral; (604) Methylergonovine; (605) Methylprednisolone; (606) Reserved; (607) Methysergide; ... Pay-Per-View - Georgia Code - Loislaw

Brand Names/Synonyms:
Methylergonovine is also known by the following brand names and/or synonymsBasofortina; CHEMBANK991; Ergometrine, Methyl-; ME 277; Metenarin; Methergen; Methergin; Methergine; Methylergobasin; Methylergobasine; Methylergobrevin; Methylergometrin; Methylergometrine; Methylergonovin; Methylergonovine; Norforms; Partergin; Ryegonovin; Spametrin-M

Drug Category:
Methylergonovine is categorized under the following by the FDA: Oxytocics

Dosage Forms:
INJECTION (intramuscular or intravenous), TABLETS

Absorption:
Absorption is rapid after oral (60% bioavailability) and intramuscular (78% bioavailability) administration.

Interactions:
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Chemical IUPAC Name:
Not Available





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