Metoprolol

This page contains recent news articles, when available, and an overview of Metoprolol but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Metoprolol
(when available)

Pharmacology and use:
Metoprolol, a competitive, beta1-selective (cardioselective) adrenergic antagonist, is similar to atenolol in its moderate lipid solubility, lack of intrinsic sympathomimetic activity (ISA), and weak membrane stabilizing activity (MSA). For the treatment of hypertension and angina pectoris

Mechanism Of Action:
Like betaxolol and atenolol, metoprolol competes with adrenergic neurotransmitters such as catecholamines for binding at beta(1)-adrenergic receptors in the heart and vascular smooth muscle. Beta(1)-receptor blockade results in a decrease in heart rate, cardiac output, and blood pressure.

News Articles on Metoprolol

Hypoglycemia Associated with the Use of Levofloxacin  -  ‎Jan 4, 2010‎
The patient also received furosemide 40 mg orally twice daily, lisinopril 20 mg orally daily, and metoprolol 25 mg twice daily. The patient was discharged ... Medscape

Learning the ABCs of high blood pressure  -  ‎Jan 4, 2010‎
These drugs end with –olol; such as metoprolol (brand name Betaloc) or atenolol. Why are beta-blockers so popular? Well, in addition to having multiple ... Philippine Star

Sandoz launches hypertension generic  -  ‎Dec 10, 2009‎
The company launched metoprolol tartrate and hydrochlorothiazide tablets, an authorized generic of Novartis' Lopressor HCT and will market the drug in the ... Drug Store News (blog)

ARCA expands scope of beta-blocker  -  ‎Dec 23, 2009‎
The proposed trial would compare Gencaro with the beta-blocker metoprolol CR/XL, which is approved for heart failure and other indications. Boulder County Business Report

ACC, AHA Update Guidelines for Beta Blockers  -  ‎Dec 15, 2009‎
However, the organizations released a focused update last month, prompted by results of a study in which fixed, higher doses of the beta blocker metoprolol ... AAFP News Now

Not All Drugs Are the Same After All  -  ‎Dec 18, 2009‎
...as Budeprion XL 300 in one generic form), the heart medicine Toprol XL (metoprolol succinate) and the antiseizure medicine Keppra (levetiracetam). ... New York Times

ARCA Announces Submission of a Request for Special Protocol Assessment for ...  -  ‎Dec 22, 2009‎
The proposed trial protocol includes a superiority comparison to the beta-blocker metoprolol CR/XL, which is approved for heart failure and other ... FOXBusiness

Efektywność leków antyarytmicznych w arytmogennej kardiomiopatii prawej komory  -  ‎Jan 4, 2010‎
Do analizy włączono 58 pacjentów leczonych beta-adrenolitykami (BB) (atenolol, bisoprolol, karwediolol, metoprolol), mediana długości terapii wynosiła 591 ... Polskie Towarzystwo Kardiologiczne

여성ì?€ 고혈압ì—? 쉽게 걸리지 않는다?  -  ‎Dec 23, 2009‎
...ê·¸ 다ì?Œìœ¼ë¡œ 베타차단제(atenolol, metoprolol), 알파-베타차단제(labetalol), 칼슘길항제(nifedipine), 알파차단제 등ë?„ 임신 후기ì—? 사용했ì?„ 때 비êµ?ì ? 안전한 약 ... 쿠키뉴스

Vaistus atpiginti įmanoma tik reguliuojant ir gamintojų kainas  -  ‎Dec 16, 2009‎
Pavyzdžiui vaistą „Metoprolol Hexal Z" 200 mg tabletėmis Lenkijoje gamintojai parduoda po 9,75 Lt, Lietuvoje - po 24,86 Lt, „Ranigast" 150 mg tabletės ... AINA

Par Pharmaceutical Reports EPS of $0.76 for Third Quarter 2009  -  ‎Nov 6, 2009‎
Metoprolol: For the quarter ended October 3, 2009, net sales of metoprolol succinate were $161.1 million, a decrease of 47% from the second quarter 2009. ... CNNMoney.com (press release)

Four Basics and Some Good Information About Beta-Blocker Treatment for High ...  -  ‎Oct 27, 2009‎
Indication and important risk information you should know about TOPROL-XL(®) (metoprolol succinate) extended-release tablets. TOPROL-XL is indicated for the ... Reuters

Watson gets boost in Q3 from new product introductions  -  ‎Nov 4, 2009‎
...million last year, thanks to the introduction of such new products as the hypertension and chest pain treatment metoprolol extended-release tablets. ... Drug Store News (blog)

2009 ACCF/AHA Focused Update on Perioperative Beta Blockade: A Report of the ...  -  ‎Nov 2, 2009‎
This stems from results of the POISE study, in which a standard, immediately preoperative dose of metoprolol succinate 100 mg BID, followed by 200 mg daily, ... Cardiosource

Brand Name: Toprol XL  -  ‎Nov 11, 2009‎
Toprol-XL (generic name: Metoprolol; brand names: Lopressor / Lopresor / Selokeen / Minax / Metrol / Betaloc / Neobloc / Corvitol) is a selective beta ... Pattaya Daily News

AstraZeneca reports jump in Q3 profit  -  ‎Oct 29, 2009‎
The withdrawal of generic versions of the hypertension drug Toprol-XL (metoprolol succinate) helped that drug account for 3% of global revenue growth. ... Drug Store News (blog)

November 2009 Mayo Clinic Health Letter Highlights Self-Care Tips for ...  -  ‎Nov 13, 2009‎
Beta blockers: Drugs in this class -- metoprolol, bisoprolol and others -- slow the heart rate and lower blood pressure. Beta blockers are the single most ... PR Newswire (press release)

Orbus Pharma Inc. Reports Third Quarter 2009 Results (All amounts in thousands ...  -  ‎Nov 13, 2009‎
The outcome from the small scale Metoprolol Succinate pilot bioequivalence studies for the USA and European products generated mixed results. ... Trading Markets (press release)

Orbus Announces Outcome of Metoprolol Succinate Pilot Bioequivalence Studies  -  ‎Oct 26, 2009‎
The company conducted a 25 subject pilot bioequivalence study under "Fed" conditions on each of three strengths of Metoprolol Succinate. ... Filing Services Canada (press release)

Information You Can Use if You Have High Blood Pressure: TOPROL-XL and its ...  -  ‎Oct 27, 2009‎
..."If patients were switched to a twice-daily metoprolol because of a supply shortage, it is important for them to know that TOPROL-XL, the extended-release ... PharmaLive.com (press release)

What Is Graves' Disease? What Causes Graves' Disease?  -  ‎Nov 6, 2009‎
The possible treatments include: Beta blockers - examples include propranolol (Inderal), atenolol (Tenormin), metoprolol (Lopressor) and nadolol (Corgard). ... Medical News Today

Perioperative Pattern of Use of Beta Blockers Affects Mortality: Presented at ASA  -  ‎Oct 21, 2009‎
Metoprolol was the most common inpatient drug (75%), and atenolol was the most common outpatient drug (54%). The patients were divided into 4 groups ... DG News

DOH opens more BnBs in Caraga region  -  ‎Oct 26, 2009‎
BnB sells low-priced generic over-the-counter drugs and six selected prescription drugs namely Captopril, Metoprolol, Metformin, Glibenclamide, ... Philippine Information Agency

Nur mit Pille ins Büro  -  ‎Nov 10, 2009‎
Sie schlucken Mittel wie etwa Fluoxetin, Metoprolol oder Modafinil, obwohl sie gar nicht die Krankheiten plagen, für die diese Wirkstoffe eigentlich ... Frankfurter Rundschau

大型研究確èª?手術å‰?後使用乙型阻斷劑的好處  -  ‎Nov 2, 2009‎
...在手術的那一天使用atenolol或是é?œè„ˆæ³¨å°„metoprolol。術後繼續使用atenolol或é?œè„ˆmetoprolol,直到開始å?£æœ?藥物。 * 術後æ¯?天å?£æœ?atenolol 100 mg,æŒ?續一個星期以上。 ... 臺灣新浪網

Par Pharmaceutical盈餘超越é ?期  -  ‎Nov 6, 2009‎
...營收æˆ?長,主è¦?是因metoprolol succinate, sum succinate, meclizinedronabinol的競爭有é™?,以å?Šç¬¬ä¸‰å­£æŽ¨å‡ºnategli clonidine。 第三季毛利為9210è?¬ç¾Žå…ƒï¼Œæ¯›åˆ©çއ ... 環球財經

Vermalen tablet soms gevaarlijk  -  ‎Nov 4, 2009‎
...etsing van de slokdarm door alendroninezuur, onwerkzaamheid van bisacodyl of een giftige dosis door wegvallen van de vertraagde afgifte van metoprolol. ... TVVonline

Doping gegen Stress und Leistungsdruck  -  ‎Oct 27, 2009‎
Methylphenidat, Modafinil, Piracetam, Fluoxetin oder Metoprolol heißen die Wirkstoffe, die auf der Dopingliste der Deutschen Angestellten Krankenkasse (DAK) ... Usinger Anzeiger

Spectrum K bringt Rabattverträge durch  -  ‎Nov 9, 2009‎
Heunet hat demnach auf sieben weiteren Fachlosen gepunktet, darunter den bedeutenden Wirkstoffen Omeprazol und Metoprolol. Das Schwesterunternehmen Heumann ... apotheke-adhoc

Doping im Job - ein gefährlicher Trend  -  ‎Oct 28, 2009‎
Obwohl Mittel wie Modafil (bei Schlafapnoe), Fluoxetin (bei Depressionen), Metoprolol (bei Bluthochdruck) und Piracetam (bei Demenz) verschreibungspflichtig ... Esslinger Zeitung

Möte om brister i äldres läkemedelsanvändning  -  ‎Oct 26, 2009‎
...hos äldre i form av uthämtade recept inom SLL juli-december 2005 var i fallande ordning ASA, furosemid, paracetamol, metoprolol och simvastatin. ... Janus

Czy zmniejszenie aktywnoÅ›ci ukÅ‚adu renina-angiotensyna zmniejsza ryzyko ...  -  ‎Oct 26, 2009‎
W grupie kontrolnej stosowano placebo (9) i/lub acebutolol (1), amlodypinÄ™ (6), atenolol (5), chlortalidon (1), metoprolol (1), nifedypinÄ™ (3), ... Medycyna Praktyczna

Jakie jest Å›rednie obniżenie ciÅ›nienia tÄ™tniczego w leczeniu skojarzonym w ...  -  ‎Oct 22, 2009‎
...chlortalidon [4], indapamid [1]), β-blokery (atenolol [9], bisoprolol [2], propranolol [2], pindolol [2], metoprolol [1], tymolol [1], nebiwolol [1]), ... Medycyna Praktyczna

Czy zmniejszenie ryzyka zgonu zwiÄ…zane z użyciem β-blokera zależy od jego ...  -  ‎Oct 19, 2009‎
W grupie eksperymentalnej stosowano w dawce stopniowo zwiększanej: metoprolol 6,25-200 mg/d (5 badań, n = 6405), karwedilol 6,25-100 mg/d (9/4794), ... Medycyna Praktyczna

TIPPS GEGEN MIGRäNE  -  ‎Oct 26, 2009‎
Medikamente der ersten Wahl sind hierfür rezeptpflichtige Betablocker wie zum Beispiel Metoprolol oder der Kalziumantagonist Flunarizin sowie das ... Gourmet-report.de

Profound metoprolol-induced bradycardia precipitated by acetaminophen...  -  Jun 8, 2005
Jeanna M. Marraffa PharmD 1 , Li Lang PhD 1 , Gilbert Ong MD 1 and David F. Lehmann MD, PharmD 1. Correspondence: Jeanna M. Marraffa, PharmD, SUNY Upstate ... Nature.com

… Genotype on the Clinical Effects of Metoprolol: A Prospective...  -  Feb 1, 2008
After administration of metoprolol, plasma concentrations of the drug are ... Despite administering equal doses to PMs and non-PMs, metoprolol plasma ... Nature.com

… on adverse effects during treatment with metoprolol: A prospective...  -  Mar 22, 2005
Methods: Patients in whom treatment with metoprolol was considered were ... The dosage of metoprolol was determined on an individual basis and could be ... Nature.com

Metoprolol around the time of surgery increases the risk of death and...  -  May 12, 2008
Hamilton, ON (May 12, 2008) - Beta-blocker drugs may help prevent heart attacks during surgery, but they may increase the risk of death and major stroke, ... Genetic Engineering News - Genetic Engineering News (press release)

AstraZeneca sees FY EPS outlook at lower-end of 3.85-3.95 usd …  -  Nov 22, 2006
It said the agreement would not affect the availability of its branded version of metoprolol succinate, Toprol-XL, and will continue to manufacture and make ... Forbes

In re Metoprolol Succinate Patent Litigation, No. 2006-1254 (Fed....  -  Jul 23, 2007
Supreme Court Cases - Research for US Supreme Court Cases, Federal Circuit Court Cases, and Federal District Court Cases. Whether you need decisions in ... $2.95 - U.S. Court of Appeals, Federal Circuit - VersusLaw

PEOPLE'S PHARMACY - Monitor reactions to generics  -  Dec 31, 2007
Toprol-XL (metoprolol) is a slow-release beta blocker prescribed to control high blood pressure and irregular heart rhythms. ... Los Angeles Times

… Hypertension Treatment With Metoprolol Succinate Extended Release ...  -  Apr 29, 2005
Conclusions: The antihypertensive effects of ER metoprolol succinate and ER felodipine are dose-related, and when given in combination, their BP-lowering ... Nature.com

US warns Novartis generic unit on plant problems  -  Aug 26, 2008
..."We are also concerned that the problems noted in the metoprolol validations could be indicative of problems and poor decisions made with other product ... Reuters

PEOPLE'S PHARMACY - Downside of beta blockers  -  Dec 24, 2007
Like other beta blocker blood-pressure medicines, metoprolol can cause fatigue, dizziness or diarrhea. Some people develop an itchy rash while taking the ... Los Angeles Times

Hope over heart attack treatment  -  Nov 4, 2005
But he said the study on metoprolol showed that such drugs should be used with caution in the early hours of an attack. Meanwhile, the Lancet also reported ... BBC News

Effects of Carvedilol Versus Metoprolol on Endothelial Function and …  -  Dec 11, 2006
Correspondence: Dr. Alan J. Bank, 225 Smith Ave. N., Suite 400, St. Paul, MN 55102 E-mail: abank@stphc.com. * Supported by a grant from GlaxoSmithKline, ... Nature.com

… Allows Sandoz (NVS) to Launch Metoprolol Succinate Extended...  -  May 21, 2007
Watson was awarded market exclusivity as the first generic applicant to submit an Abbreviated New Drug Application (ANDA) for metoprolol succinate ... StreetInsider.com - StreetInsider.com (subscription)

In re Metoprolol Succinate Patent Litigation, No. 1620 (EDMo....  -  Jan 17, 2006
Supreme Court Cases - Research for US Supreme Court Cases, Federal Circuit Court Cases, and Federal District Court Cases. Whether you need decisions in ... $2.95 - U.S. District Court, Eastern District... - VersusLaw

KV Pharmaceutical says FDA OKs generic of heart drug Toprol XL  -  May 18, 2007
The approval is for 100 mg and 200 mg strengths of metoprolol succinate extended-release tablets, the company said in a statement. ... Reuters

Felodipine–Metoprolol Combination Tablet: Maintained Health-Related …  -  Jan 26, 2005
Correspondence: Dr. Alessio Degl' Innocenti, Medical Science, AstraZeneca R&D, SE-431 83 Mölndal, Sweden E-mail: alessio.deglinnocenti@astrazeneca.com ... Nature.com

Metoprolol for acute myocardial infarction.(Disease/Disorder overview)  -  Jun 15, 2006
Beta-blocker therapy has been proven to benefit patients with heart failure, arrhythmias, hypertension, or unstable angina. In some studies, early use of ... Free with registration - American Family Physician - AccessMyLibrary.com

KV Pharmaceutical gets FDA approval for generic heart drug dosage  -  May 15, 2008
The FDA approved KV's Abbreviated New Drug Application (ANDA) for its 50 mg strength of the metoprolol succinate extended-release tablets. ... Bizjournals.com

Carvedilol, Metoprolol, and Insulin Resistance  -  Mar 9, 2005
To the Editor: The study by Dr Bakris and colleagues 1 comparing the metabolic effects of carvedilol vs metoprolol in patients with type 2 diabetes mellitus ... Journal of American Medical Association - Journal of American Medical Association...

HIGH-DOSE METOPROLOL INCREASES MORTALITY IN HIGH-RISK …  -  Aug 31, 2008
Perioperative beta blockers have been promoted to reduce the risk for perioperative MI. However, while high-dose perioperative extended-release metoprolol ... Clinical Advisor

Metoprolol After Vascular Surgery (MaVS)  -  Feb 20, 2007
Description: The goal of the trial was to evaluate whether perioperative beta-blocker administration of metoprolol is associated with a reduction in cardiac ... Medscape

… Bioequivalence Results in Its Metoprolol Succinate Extended...  -  May 23, 2006
Metoprolol succinate is the world's leading cardioselective beta-blocker for hypertension, angina pectoris, heart failure, disturbances of cardiac rhythm ... ccnmatthews.com

Par begins shipping generic Toprol  -  Jul 26, 2007
The company said it would ship metoprolol succinate extended release tablets in 100-mg and 200-mg strengths. The move comes as part of a supply and ... United Press International

Carvedilol reduces microalbuminuria v metoprolol  -  Mar 14, 2005
Orlando, FL - A new study suggests that treatment with the beta blocker carved ilol (Coreg¿, GlaxoSmithKline) reduced microalbuminuria among patients with ... Medscape

… Bioequivalence Results in its Metoprolol Succinate Extended Releas  -  Sep 7, 2006
Metoprolol succinate is the world's leading cardioselective beta-blocker for hypertension, angina pectoris, heart failure, disturbances of cardiac rhythm ... ccnmatthews.com

β Blockers Increase Risk Of Death And Stroke After Non-Cardiac...  -  May 15, 2008
Fewer patients in the metoprolol group reached the primary endpoint than the ... However, overall, there were more deaths in the metoprolol group than the ... Medical News Today - Medical News Today (press release)

… to Permit Sandoz to Launch Metoprolol Succinate Extended-Release 50  -  May 21, 2007
Watson Enters Into Agreement to Permit Sandoz to Launch Metoprolol Succinate Extended-Release 50 mg Tablets; Relinquishes 180-Day Market Exclusivity. from ... Pay-Per-View - PR Newswire - HighBeam Research

Metoprolol CR/XL Safe, Effective for Heart Failure in Diabetics  -  Feb 1, 2005
In patients with diabetes and heart failure, treatment with the beta-blocker metoprolol succinate CR/XL (controlled release/extended release) safely reduces ... Diabetes In Control

Safety, efficacy shown for metoprolol, ramipril.(Clinical Rounds)  -  Nov 1, 2006
NEW YORK -- Two different classes of antihypertensive drugs were safe and effective for use in children based on results from two separate studies reported ... Free with registration - Pediatric News - AccessMyLibrary.com

New Onset Diabetes More Likely With Metoprolol Than With Carvedilol...  -  Aug 14, 2007
Previous studies have shown carvedilol to have a more favorable effect on glucose metabolism than other beta blockers have, the authors explain. ... Diabetes In Control

Article: AstraZeneca clips forecast, announces a new generic. - …  -  Nov 23, 2006
Generic Toprol-XL, whose chemical name is metoprolol, benefits patients and insurers ... Adding the beta-blocker Toprol-XL(R) (metoprolol succinate extended ... Pay-Per-View - Philadelphia Inquirer - HighBeam Research

Reversing Heart Damage Through Gene Therapy  -  Dec 30, 2008
Dr. Koch said that targeting the GRK2 enzyme with bARKct was sufficient to reverse heart failure even without concomitant metoprolol. ... RedOrbit

KV revenue up 61 percent St. Louis Business Journal  -  Nov 20, 2007
The company attributed the improvement in part to the July launch of the company's AstraZeneca's Toprol-XL, Metoprolol Succinate Extended Release Tablets, ... Bizjournals.com

Emergency clopidogrel could save 1000's of lives worldwide - findings...  -  Mar 9, 2005
The study also established that giving the beta-blocker metoprolol as an emergency ... [2] COMMIT/CCS-2: ClOpidogrel and Metoprolol in Myocardial Infarction ... Medical News Today - Medical News Today (press release)

overdose of metoprolol  -  Oct 20, 2008
...my wife thinks she took six tablets of metroprolol instead of regular pills this morning. what prblems can this cause. Metoprolol is a beta blocker drug. ... HealthCentral.com

… Opinions - IN RE METOPROLOL SUCCINATE PATENT LITIGATION ( …  -  Jan 17, 2006
IN RE METOPROLOL SUCCINATE PATENT LITIGATION (E.D.Mo. 2006) ... Metoprolol succinate is an active chemical compound used in the treatment of angina, ... Pay-Per-View - Loislaw Federal District Court Opinions - Loislaw

… Inc. announces succesful bioequivalence results for its metoprolol...  -  Feb 27, 2007
Metoprolol succinate is the world's leading cardioselective beta-blocker for ... The Orbus metoprolol succinate XR formulation is a generic version of Astra ... Pay-Per-View - M2 Presswire - HighBeam Research

… Submits New Drug Application for TOPROL-XL(R)(metoprolol succinate)...  -  Nov 1, 2005
AstraZeneca Submits New Drug Application for TOPROL-XL(R)(metoprolol succinate)/Hydrochlorothiazide Combination Tablets for the Management of Hypertension. Pay-Per-View - PR Newswire - HighBeam Research

Family history a big factor in heart attack, artery clogging risk .  -  Jul 16, 2008
After his surgery, he was put on Coumadin, Zocor and metoprolol. How long does he have to take these medicines? What kinds of exercise can he do? ... Herald-Journal - Google News Archive

… Court of Appeals Reports - IN RE METOPROLOL SUCCINATE, 494 F.3d …  -  Jul 23, 2007
I. Astra manufactures and markets metoprolol succinate in "extended release" ... Metoprolol is a therapeutically active compound, which can form salts by ... Pay-Per-View - United States Federal Circuit Court of... - Loislaw

Detrimental Effects of [Beta]-Blockers in COPD*: A Concern for …  -  Mar 30, 2005
Intervention: Fifteen patients received propranolol (80 mg), metoprolol (100 ... The doses of the cardioselective β-blockers metoprolol and celiprolol were ... RedOrbit

Press Release: Par Pharmaceutical Begins Shipment of Generic TOPROL …  -  Nov 21, 2006
Par began shipping metoprolol succinate extended release 25 mg tablets today. ... Metoprolol succinate extended release is indicated for the treatment of ... Pay-Per-View - PR Newswire - HighBeam Research

… applications for extented release Metoprolol Succinate published. ...  -  May 17, 2007
Orbus patent applications for extented release Metoprolol Succinate published. from M2 Presswire. Highbeam Research – FREE Trial. Pay-Per-View - M2 Presswire - HighBeam Research

KV Pharma shares dive after painkiller recall  -  Dec 24, 2008
The company makes a total of 12 tablet drugs, including the hypertension and angina treatment metoprolol and the opioid painkiller oxycodone. ... International Business Times

… With TOPROL-XL(R) (Metoprolol Succinate) Extended-Release Tablets ...  -  May 16, 2005
TOPROL-XL has been formulated to provide a controlled and predictable release of metoprolol succinate for once-daily administration. ... RedOrbit

Safety, efficacy shown for metoprolol, ramipril.(Clinical Rounds) |...  -  Nov 1, 2006
Safety, efficacy shown for metoprolol, ramipril.(Clinical Rounds) ... find Pediatric News articles. NEW YORK -- Two different classes of antihypertensive ... Pay-Per-View - Pediatric News - HighBeam Research

Lower blood pressure without side effects  -  Dec 25, 2007
A: Metoprolol, like other beta blocker blood pressure medicines, may cause fatigue, dizziness or diarrhea. Some people develop an itchy rash while taking ... Roanoke Times

… for Toprol-XL (metoprolol succinate)/hydrochlorothiazide combinatio...  -  Nov 1, 2005
The product is a combination of Toprol-XL [metoprolol succinate extended-release and the thiazide diuretic, hydrochlorothiazide (HCT)]. ... Free with registration - Asia Africa Intelligence Wire - AccessMyLibrary.com

Genetic Variation in the CYP2D6 Gene Is Associated With a Lower Heart...  -  Apr 22, 2008
In CYP2D6 *4/*4 PMs, the adjusted heart rate in metoprolol users was 8.5 beats/min ... Among the -blockers, metoprolol is most extensively metabolized by ... Nature.com

Metoprolol vs Propranolol for Unstable Angina  -  Aug 29, 2007
A patient with unstable angina was taking isosorbide dinitrate and propranolol when deep vein thrombosis (DVT) developed suddenly. She had 2 episodes, ... Medscape

Influence of phenotype and pharmacokinetics on -blocker drug target …  -  Jan 10, 2006
Two common polymorphisms in the 1 -adrenergic receptor gene, Ser49Gly and Arg389Gly, are associated with variable antihypertensive response to metoprolol. ... Nature.com

… ; Pharmacokinetic variability of metoprolol in metabolizers of...  -  Jan 1, 2005
2005 JAN 1 - (NewsRx.com & NewsRx.net) -- A recent report described nonlinear mixed effects model analysis of the pharmacokinetics of metoprolol in ... Pay-Per-View - Obesity, Fitness & Wellness Week - Factiva, from Dow Jones

KV Pharmaceutical Updates Metoprolol Succinate Application Status.  -  Mar 28, 2007
ST. LOUIS, March 28 /PRNewswire-FirstCall/ -- KV Pharmaceutical Company today updated its timing on its pending first-to-file application with the Food and ... $4.95 - PR Newswire - ECNext

Treatments and drugs  -  Aug 8, 2008
Beta blockers such as metoprolol (Lopressor) are designed to treat high blood pressure. However, they are also the type of drug used most often to prevent ... MayoClinic.com

… bioequivalence results for its metoprolol succinate extended...  -  Feb 27, 2007
Metoprolol succinate is the world's leading cardioselective beta-blocker for hypertension, angina pectoris, heart failure, disturbances of cardiac rhythm ... $4.95 - M2 Presswire - ECNext

… bioequivalence results the 95 MG Metoprolol Succinate extended...  -  Jun 20, 2007
Metoprolol succinate is the world's leading cardioselective beta-blocker for hypertension, angina pectoris, heart failure, disturbances of cardiac rhythm ... $4.95 - M2 Presswire - ECNext

… Wilmington, DE) beta blocker Toprol-XR (metoprolol succinate).(Phase...  -  Jul 1, 2005
AstraZeneca's (Wilmington, DE) beta blocker Toprol-XR (metoprolol succinate) showed efficacy in treating hypertensive children. Free with registration - Applied Clinical Trials - AccessMyLibrary.com

AstraZeneca says has full confidence in Toprol XL patents.  -  Aug 2, 2006
It made the statement after the US Food & Drug Administration granted approval to Novartis' Sandoz for 25 mg of metoprolol succinate, a generic form of ... Free with registration - America's Intelligence Wire - AccessMyLibrary.com

FDA approved a new starting dose range for metoprolol.(FAD actions in...  -  Apr 1, 2005
FDA approved a new starting dose range for metoprolol (Toprol, AstraZeneca) in the treatment of hypertension. The starting dose range was changed from ... Free with registration - Formulary - AccessMyLibrary.com

[beta]-blockers for heart failure.(Drug Update)  -  Sep 1, 2005
Although the efficacy of bisoprolol, carvedilol, and metoprolol has been documented ... This study compared carvedilol, a nonselective agent, to metoprolol, ... Free with registration - Skin & Allergy News - AccessMyLibrary.com

Orbus patent applications for extented release Metoprolol Succinate …  -  May 17, 2007
The Orbus Metoprolol Succinate XR formulation is a generic version of Astra Zeneca's Beloc-ZOK(r) (metoprolol CR/XL) which had reported 2005 annual sales of ... $4.95 - M2 Presswire - ECNext

… Treatment with TOPROL-XL(R) (metoprolol succinate) Extended...  -  May 16, 2005
New Study Reports Treatment with TOPROL-XL(R) (metoprolol succinate) Extended-Release Tablets for Hypertensive Children. from PR Newswire. Pay-Per-View - PR Newswire - HighBeam Research

Name Similarities With Toprol Results in Medication Errors  -  Sep 27, 2005
The reports include instances where metoprolol succinate ... Inappropriate exposure to metoprolol succinate has resulted in adverse events such as ... Medscape

… Treatment with TOPROL-XL(R) (metoprolol succinate) Extended...  -  May 17, 2005
New Study Reports Treatment with TOPROL-XL(R) (metoprolol succinate) Extended-Release Tablets for Hypertensive Children. from PR Newswire. Pay-Per-View - PR Newswire - HighBeam Research

Press Release: Par Pharmaceutical Begins Shipment of Additional …  -  Jul 26, 2007
Important information about metoprolol succinate extended release tablets. Metoprolol succinate extended release is indicated for the treatment of ... Pay-Per-View - PR Newswire - HighBeam Research

KV clarifies citizen petition filed with FDA.  -  Oct 20, 2006
...filed a Citizen Petition pertaining to generic equivalents of the 100mg and 200mg strengths of Toprol XL (metoprolol succinate extended-release tablets) ... Pay-Per-View - Company Reports - Factiva, from Dow Jones

Press Release: Sandoz Receives FDA Approval for Generic Toprol XL(R) ...  -  May 21, 2007
Launch plans and timing for metoprolol succinate 50 mg ER have not been finalized ... People taking TOPROL-XL or metoprolol succinate for their high blood ... Pay-Per-View - PR Newswire - HighBeam Research

Press Release: Sandoz Launches Generic Version Of Toprol XL(R) 50 …  -  Aug 2, 2007
Metoprolol succinate 50 mg ER is a beta-blocker used to treat angina, heart failure ... There can be no guarantee that metoprolol succinate will receive any ... Pay-Per-View - PR Newswire - HighBeam Research

Q1 and Q2 2007 Par Pharmaceutical Companies, Inc. Earnings …  -  Nov 21, 2007
These increases are partially offset by higher sales of metoprolol 25, which has a lower gross margin percentage than the Company's overall gross margin ... Free with registration - Fair Disclosure Wire - AccessMyLibrary.com

4-27 GOTT.xml  -  Apr 27, 2008
I am a 60-year-old female, 50 pounds overweight and take metoprolol, ... Interestingly, both simvastatin and metoprolol list depression as a side effect. ... $3.50 - Intelligencer, The - NewsBank

Metoprolol succinate extended-release tablets.  -  Jan 8, 2007
Metoprolol succinate extended-release tablets. Par Pharmaceutical, Woodcliff Lake, N.J., (800) 828-9393, is shipping metoprolol succinate extended-release ... $9.94 - Drug Topics - Alacra Store

Metoprolol succinate extended-release tablets.(NEW GENERICS)(Par …  -  Jan 8, 2007
Par Pharmaceutical, Woodcliff Lake, NJ, (800) 828-9393, is shipping metoprolol succinate extended-release tablets in 25-mg strength. $4.95 - Drug Topics - ECNext

Press Release: TOPROL-XL(R) (metoprolol succinate) US Patent …  -  Sep 30, 2005
TOPROL-XL(R) (metoprolol succinate) US Patent Litigation. from PR Newswire. Highbeam Research – FREE Trial. Pay-Per-View - PR Newswire - HighBeam Research

Metoprolol succinate extended-release tablets.(NEW GENERICS)(Brief …  -  Aug 20, 2007
Par Pharmaceutical, Woodcliff Lake, NJ, (800) 828-9393, is shipping two new tablet strengths of metoprolol succinate extended-release tablets: 100 mg and ... $4.95 - Drug Topics - ECNext

Metoprolol succinate extended-release tablets.  -  Aug 20, 2007
Metoprolol succinate extended-release tablets. Par Pharmaceutical, Woodcliff Lake, N.J., (800) 828-9393, is shipping two new tablet strengths of metoprolol ... $9.94 - Drug Topics - Alacra Store

… : KV Pharmaceutical Updates Metoprolol Succinate Application...  -  Mar 28, 2007
KV Pharmaceutical Updates Metoprolol Succinate Application Status. from PR Newswire. Highbeam Research – FREE Trial. Pay-Per-View - PR Newswire - HighBeam Research

Par launches authorized generic version of AstraZeneca heart drug  -  Nov 28, 2006
The announcement followed the launch of a 25-mg generic version of metoprolol in the US by Eon Labs, part of Sandoz. Par's authorized generic also is being ... DM News

TOPROL-XL(R) (metoprolol succinate) US Patent Litigation.  -  Sep 30, 2005
WILMINGTON, Del., Sept. 30 /PRNewswire-FirstCall/ -- AstraZeneca today announced that it had received confirmation that its pending litigation to enforce ... $4.95 - PR Newswire - ECNext

New JACC analysis details cardiovascular protective benefits of …  -  Mar 12, 2007
During the study, 106 of the 160 patients on metoprolol tartrate who had a ... *The Carvedilol Or Metoprolol European Trial (COMET) compared carvedilol ... webwire.com

New JACC Analysis Details Cardiovascular Protective Benefits of …  -  Mar 9, 2007
During the study, 106 of the 160 patients on metoprolol tartrate who had a ... *The Carvedilol Or Metoprolol European Trial (COMET) compared carvedilol ... prweb.com

Microalbuminuria risk drops with carvedilol.(Metabolic Disorders)  -  Apr 15, 2005
Treatment with carvedilol cut the incidence of new-onset microalbuminuria by 47%, compared with metoprolol, in a study of more than 700 patients with type 2 ... Free with registration - Family Practice News - AccessMyLibrary.com

Press Release: Par Pharmaceutical Begins Shipment of Additional …  -  Aug 3, 2007
ANDA) for metoprolol succinate extended-release 50 mg tablets. ... European drug development of the 95 mg metoprolol succinate extended release ("XR") ... Pay-Per-View - PR Newswire - HighBeam Research

Orbus Pharma Inc. Reports Second Quarter 2006 Results  -  Aug 9, 2006
...phase of the bioequivalence studies in its European drug development of a once per day formulation for metoprolol succinate extended release tablets. ... ccnmatthews.com

Competitors by Product Report  -  Sep 13, 2008
Ethex Metoprolol Succinate; Ethex Metoprolol Succinate Extended Release ... Acebutolol HCl; Metoprolol Succinate; Metoprolol Succinate Extended Release ... $75.00 - Revere Reports - Revere

FDA Approves Updated Labeling for COREG®  -  Jun 1, 2005
Additionally, results from the Carvedilol or Metoprolol European Trial ... It is not known whether this formulation of metoprolol at any dose or this low ... DentalPlans.com

GSK Announces Nationwide Availability of Once-A-Day COREG CR(TM) …  -  Mar 22, 2007
Major carvedilol studies include COMET (the Carvedilol or Metoprolol European ... It is not known whether this formulation of metoprolol at any dose or this ... RedOrbit

GSK, FLAMEL'S ONCE-A-DAY COREG CR WINS FDA APPROVAL  -  Oct 24, 2006
3000 heart failure patients that demonstrated patients receiving Coreg lived 1.4 years longer compared with patients taking the metoprolol tartrate. ... Pay-Per-View - FDAnews Drug Pipeline Alert - Factiva, from Dow Jones

Competitors by Product Report  -  Sep 13, 2008
Ethex Metoprolol Succinate; Ethex Metoprolol Succinate Extended Release ... Atenolol; Carvedilol; Metoprolol Tartrate; Propranolol Hydrochloride ... $75.00 - Revere Reports - Revere

Par Pharmaceutical Ships Additional Dosage Strength Of Generic …  -  Aug 8, 2007
Metoprolol succinate extended release is indicated for the treatment of ... Metoprolol succinate extended release should be used with caution in patients ... emaxhealth.com

Article: AztraZeneca's woes offer long-term opportunity.(WALL STREET ...  -  Feb 1, 2005
Article: FDA Approves AstraZeneca's Toprol-XL -- Metoprolol ... ... sNDA) for the use of the beta-blocker Toprol-XL(R) (metoprolol succinate) extended ... Pay-Per-View - Medical Marketing & Media - HighBeam Research

Article: AstraZeneca cuts earnings forecast ; Business News IN BRIEF ...  -  Nov 23, 2006
Article: FDA Approves AstraZeneca's Toprol-XL -- Metoprolol ... ... sNDA) for the use of the beta-blocker Toprol-XL(R) (metoprolol succinate) extended ... Pay-Per-View - Independent - London - HighBeam Research

FDA Approves Updated Labeling for Coreg(R) Showing Benefits for Heart...  -  May 24, 2005
Additionally, results from the Carvedilol or Metoprolol European Trial ... It is not known whether this formulation of metoprolol at any dose or this low ... $4.95 - PR Newswire - ECNext

Press Release: FDA Approves Updated Labeling for Coreg(R) Showing …  -  May 24, 2005
Additionally, results from the Carvedilol or Metoprolol European Trial ... It is not known whether this formulation of metoprolol at any dose or this low ... Pay-Per-View - PR Newswire - HighBeam Research

Competitors by Product Report  -  Mar 29, 2008
Ethex Metoprolol Succinate; Ethex Metoprolol Succinate Extended Release ... Acebutolol HCl; Metoprolol Succinate; Metoprolol Succinate Extended Release ... $75.00 - Revere Reports - Revere

Carvedilol boosts survival and cuts cost beta  -  Apr 30, 2005
..."Physicians prescribing metoprolol instead of carvedilol to save money ... The mean doses prescribed were 70mg for metoprolol and 24mg for carvedilol daily. ... National Review of Medicine

Polymorphisms of norepinephrine transporter and adrenergic receptor...  -  Apr 3, 2007
Recently, Carvedilol or Metoprolol European Trial (COMET) has proposed that ... Metoprolol and carvedilol are mainly metabolized by the polymorphic CYP2D6 ... Nature.com

Press Release: AstraZeneca Launches Awareness Campaign to Support …  -  May 19, 2006
Article: FDA Approves AstraZeneca's Toprol-XL -- Metoprolol ... ... The product is a combination of TOPROL-XL (R) (metoprolol succinate extended ... Pay-Per-View - PR Newswire - HighBeam Research

Article: Top 10 drugs mentioned by cardiologists in 2004.(Illustration...  -  Jun 15, 2005
Article: FDA Approves AstraZeneca's Toprol-XL -- Metoprolol . ... The product is a combination of TOPROL-XL (R) (metoprolol succinate extended ... diuretic, ... Pay-Per-View - Internal Medicine News - HighBeam Research

Does the risk of developing diabetes in hypertensive kidney disease...  -  Jul 12, 2006
The incidence of diabetes per patient-year was 2.8% in the ramipril group, 4.5% in the metoprolol group and 4.4% in the amlodipine group, and the rates of ... Nature.com

United States top 190 multisource generic drugs ranked by sales in …  -  Sep 29, 2008
Meloxicam 69 Cobalt Ramipril 70 Sandoz Metoprolol succinate 71 ... Metoprolol succinate 94 Mylan Nifedipine ER 95 Barr Fluoxetine HCl 96 Anchen Pharm. ... $20.00 - Chain Drug Review - Alacra Store

Brand Names/Synonyms:
Metoprolol is also known by the following brand names and/or synonymsBeloc; Betaloc; CGP 2175; H 93/26; H-23/96; LOPRESSOR HCT; Lopresor; Lopresoretic; Lopressor; Metoprolol; Metoprolol Tartrate; Metroprolol; Prelis; Selo-Zok; Seloken; Selopral; Toprol; Toprol-Xl

Drug Category:
Metoprolol is categorized under the following by the FDA: Sympatholytics; Antihypertensive Agents; Antiarrhythmic Agents; Adrenergic Agents; ATC:C07AB02; ATC:C07AB52

Dosage Forms:
Tablets

Absorption:
rapid and complete, 50%

Interactions:
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Chemical IUPAC Name:
1-[4-(2-methoxyethyl)phenoxy]-3-(1-methylethylamino)propan-2-ol





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