Moclobemide

This page contains recent news articles, when available, and an overview of Moclobemide but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Moclobemide
(when available)

Pharmacology and use:
Moclobemide belongs to a class of MAOI antidepressants known as reversible inhibitors of monoamine oxidase type-A (RIMAs). The primary role of monoamine oxidase MAO lies in the metabolism of and regulation of the levels of monoamines (serotonin, norepinephrine, and dopamine). Within neurons, MAO appears to regulate the levels of monoamines released upon synaptic firing. Since depression is associated with low levels of monoamines, the inhibition of MAO serves to ease depressive symptoms. RIMAs demonstrate transient inhibition of the substrate binding site of MAO-A as well as competitive displacement from this site by bioamines. The RIMAs are distinguished from the older monoamine oxidase inhibitors (MAOIs) by their selectivity and reversibility. Depression

Mechanism Of Action:
The mechanism of action of Moclobemide involves the selective, reversible inhibition of MAO-A. This inhibition leads to a decrease in the metabolism and destruction of monoamines in the neurotransmitters. This results in an increase in the monoamines, relieving depressive symptoms.

News Articles on Moclobemide

Old Antidepressant Offers Promise in Treating Heart Failure  -  05 Jan 2010
He says newer drugs in the same class, such as moclobemide (sold as Aurorix or Manerix, and already approved by the US Food and Drug Administration), ... Newswise (press release)

Combining antidepressants: understanding drug interactions is the sine qua non  -  ‎Jan 3, 2010‎
The section headed 'SSRI with moclobemide' shows a lack of familiarity with the literature on reversible inhibitors of monoamine oxidase A (RIMAs) and SSRIs ... Adv Psychiatric Treat (subscription)

Lena Palaniyappan , Lisa Insole and Nicol Ferrier  -  ‎Jan 3, 2010‎
With respect to the moclobemide and SSRI combination, we agree that we could have emphasised the risk of using this combination in more detail, ... Adv Psychiatric Treat (subscription)

Moclobemide (Systemic).(Drug overview)  -  Aug 1, 2006
...is a monoamine oxidase (MAO) inhibitor used to relieve certain types of mental depression. It works by blocking the action of a chemical substance known as ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

MOCLOBEMIDE (Oral route) - moe-KLOE-be-mide.(Drug overview)  -  May 1, 2007
...is a monoamine oxidase (MAO) inhibitor used to relieve certain types of mental depression. It works by blocking the action of a chemical substance known as ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

… placebo-controlled trial of moclobemide, cognitive- behavioural...  -  Sep 1, 2008
BACKGROUND: In the treatment of panic disorder with agoraphobia, the efficacy of pharmacological, psychological and combined treatments has been established ... British Journal of Psychiatry (subscript...

What's the evidence for monoamine oxidase inhibitors (MAOIs)?  -  Dec 4, 2008
It found that moclobemide worked as well at reducing panic attacks as ... It looked at the effects of moclobemide plus cognitive behavioural therapy (CBT), ... guardian.co.uk

Monoamine Oxidase Inhibition for Tobacco Pharmacotherapy  -  Oct 5, 2007
This phenomenon is negligible with selective (reversible) MAOIs such as moclobemide, because of the rapid recovery of the MAO enzyme that allows tyramine to ... Nature.com

Sertraline (Systemic).  -  Feb 1, 2006
Use of moclobemide with sertraline is not recommended. Also, it is recommended that 3 to 7 days be allowed between stopping treatment with moclobemide and ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Paroxetine (Systemic).  -  Oct 27, 2005
Moclobemide (eg, Manerix) -- The risk of developing serious unwanted effects, including the ... Use of moclobemide with paroxetine is not recommended. ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Fluoxetine (Systemic).  -  Jul 28, 2005
Use of moclobemide with fluoxetine is not recommended. Also, it is recommended that 7 days be allowed between stopping treatment with moclobemide and ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Fluoxetine (Systemic).(Drug overview)  -  Aug 1, 2006
Use of moclobemide with fluoxetine is not recommended. Also, it is recommended that 7 days be allowed between stopping treatment with moclobemide and ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Sertraline (Systemic).(Drug overview)  -  May 1, 2006
Use of moclobemide with sertraline is not recommended. Also, it is recommended that 3 to 7 days be allowed between stopping treatment with moclobemide and ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

The right drug in mild to moderate depression.(Disease/Disorder …  -  Mar 1, 2006
Patients on moclobemide must still avoid sympathomimetic substances, ... In addition to gastrointestinal upset, moclobemide may cause restlessness, ... Free with registration - Update - AccessMyLibrary.com

Plasma Drug Concentrations and Physiological Measures in 'Dance Party...  -  Sep 28, 2005
The presence of moclobemide in one sample was confirmed by gas ... Other drugs detected were benzodiazepines (three subjects), moclobemide (one subject), ... Nature.com

استشارات Ù†Ù?سية واجتماعية  -  Jul 14, 2006
وصÙ? لي الدكتور دواء Moclobemide 051mq أريد أن أعرÙ? ... الاخت بدور دواء Moclobemide بجرعة - 15 ملجم دواء ... الرياض

PulseClinical: NEED TO KNOW - PRESCRIBING ANTIDEPRESSANTS.  -  Oct 24, 2007
Moclobemide is a second-line drug for social phobia and an alternative second-line ... Washout periods are required when changing to and from moclobemide. ... Free with registration - Pulse - AccessMyLibrary.com

Venlafaxine (Systemic).(Drug overview)  -  May 1, 2006
Moclobemide (eg, Manerex) -- Taking moclobemide and venlafaxine together or less than 3 days apart may increase the chance of developing serious unwanted ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Venlafaxine (Systemic).  -  Aug 1, 2006
Moclobemide (eg, Manerex) -- Taking moclobemide and venlafaxine together or less than 3 days apart may increase the chance of developing serious unwanted ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Sibutramine (Systemic).  -  Feb 1, 2006
If you develop these symptoms, contact your doctor as soon as possible Moclobemide (eg, Manerex) -- Taking moclobemide and sibutramine together or less than ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

::: ê±´ê°•ì?´ ë³´ì?´ëŠ” 대한민국 대표 ì?˜ë£Œì‹ ë¬¸ 메디컬투ë?°ì?´ :::  -  Dec 13, 2007
...문제는 시�중� 항우울제(moclobemide, Selegellne)� 티�민� 다량 함유� ... 정부� �약품정보�서는 moclobemide, Selegellne �� '티�민� 다량 함유� ... 메디컬투��

Seasonal Affective Disorder, a Common But Shadowy Condition  -  Dec 29, 2005
...agents which have been shown to be effective in randomized trials include Prozac (fluoxetine) and the monoamine oxidase inhibitor Manerix (moclobemide). ... CNN

Lives at risk with antidepressant prescribing  -  Sep 1, 2008
The most commonly prescribed serotonin combinations were moclobemide with an SSRI or tramadol, say researchers from the University of NSW in the British ... 6minutes

Commentary on the EULAR recommendations for the management of …  -  Mar 3, 2008
For example, the authors state that "antidepressants (such as) amitriptyline, fluoxetine, duloxetine, milnacipran, moclobemide and pirlindole, ... Nature.com

Article: Dear Rachael: Why I'll let wife sleep with a pal.(Features) ...  -  Nov 18, 2007
Antidepressant-induced sexual dysfunction during treatment with moclobemide ... antidepressant-induced sexual dysfunction have been inconsistent due ... ... Pay-Per-View - The People - HighBeam Research

Helping kids with ADHD  -  Aug 18, 2005
When these medications are not effective, other drugs such as Imipramine, Clonidine, Moclobemide and Desipramine are used. ... Malaysia Star

Man held on poison deaths  -  Feb 9, 2007
Shaun Bateson and Brian Hadfield, both 22 and of Sydney, died in 2004 after taking a mixture of two anti-depressant drugs, venlafaxine and moclobemide. ... The Australian

Pill kill accused 'incoherent'  -  Feb 9, 2007
Bateson and 29-year-old Brian Hadfield in Sydney in 2004 by supplying them a mixture of the prescription medications of venlafaxine and moclobemide. ... NEWS.com.au

Milwaukee Journal Sentinel : DRUG CAPSULE WHAT YOU SHOULD …  -  Jul 4, 2005
Interactions: This drug should not be taken with MAO inhibitors (e.g., furazolidone, isocarboxazid, linezolid, moclobemide, phenelzine, procarbazine, ... $2.95 - Milwaukee Journal Sentinel - NewsBank

Article: BRAIN SCAN USE HELPS FEMALE SEX RESEARCH.(News) - …  -  Sep 6, 2005
Antidepressant-induced sexual dysfunction during treatment with moclobemide ... antidepressant-induced sexual dysfunction have been inconsistent due ... ... Pay-Per-View - Cincinnati Post - HighBeam Research

Article: Dear Rachel: Should I let wife bedmate?(Features) - The...  -  Mar 19, 2006
Antidepressant-induced sexual dysfunction during treatment with moclobemide ... antidepressant-induced sexual dysfunction have been inconsistent due ... ... Pay-Per-View - The People - HighBeam Research

DRUG CAPSULE WHAT YOU SHOULD KNOW  -  Jan 15, 2007
...taking monoamine oxidase inhibitors (eg, furazolidone, isocarboxazid, linezolid, moclobemide, phenelzine, procarbazine, selegiline, tranylcypromine). $2.95 - Milwaukee Journal Sentinel - NewsBank

DRUG CAPSULE WHAT YOU SHOULD KNOW | Article from The …  -  Jul 4, 2005
Interactions: This drug should not be taken with MAO inhibitors (e.g., furazolidone, isocarboxazid, linezolid, moclobemide, phenelzine, procarbazine, ... Pay-Per-View - Milwaukee Journal Sentinel - HighBeam Research

Meda Acquires Product Portfolio From Roche  -  Aug 15, 2008
Aurorix (moclobemide) is a MAO-A inhibitor and a well-known antidepressant for specialists to prescribe. Aurorix shows stable market share and a strong ... RedOrbit

Two dead after fatal mix of prescription drugs  -  Nov 12, 2006
A post-mortem found Mr Bateson had died from "serotonin syndrome" caused by ingesting two anti-depressants: venlafaxine (brand name Effexor) and moclobemide ... NEWS.com.au

DRUG CAPSULE WHAT YOU SHOULD KNOW | Article from The …  -  Jan 15, 2007
Interactions: Tell you're doctor if you're taking monoamine oxidase inhibitors (e.g., furazolidone, isocarboxazid, linezolid, moclobemide, phenelzine, ... Pay-Per-View - Milwaukee Journal Sentinel - HighBeam Research

Aspen grows sick of waiting for extra price hikes  -  Sep 9, 2008
Paul Anley, the managing director at Pharma Dynamics, said the firm had been granted an extra 7 percent for Bezafibrate, Carvedilol, Moclobemide and ... Business Report

Article: Girlfriend's undies make me feel so comfortable.(Features) -...  -  Jan 30, 2008
Antidepressant-induced sexual dysfunction during treatment with moclobemide ... antidepressant-induced sexual dysfunction have been inconsistent due ... ... Pay-Per-View - Daily Record - HighBeam Research

News Briefs - Corporate - Express Pharma Pulse  -  May 19, 2005
Fenofibrate, Modafinil, Cilostazol, Azithromycin monohydrate, Moclobemide. The approval was granted without a single 483, a company release stated. ... expresspharmapulse.com

Antidepressant relieves pain in fibromyalgia.(Neurology)(Clinical...  -  Aug 15, 2008
Other antidepressants that have shown benefits in varying numbers and sizes of trials are fluoxetine, duloxetine, milnacipran, moclobemide, and pirlindole. ... Pay-Per-View - Internal Medicine News - HighBeam Research

EULAR Issues Guidelines for the Treatment of Fibromyalgia Syndrome  -  Sep 21, 2007
Appropriate options may include amitriptyline, fluoxetine, duloxetine, milnacipran, moclobemide, and pirlindole. Tropisetron, pramipexole, and pregabalin ... Medscape

Pharmacotherapy of Depression in Older Adults  -  Sep 29, 2005
Comparison of the efficacy of moclobemide and fluvoxamine in elderly patients with a severe depressive episode. Eur Psychiatry 1993;8:319-24. ... Medscape

Milnacipran could improve fibromyalgia-related pain.(Pain Medicine) |...  -  Sep 1, 2008
Other antidepressants that have shown benefits in varying numbers and sizes of trials were fluoxetine, duloxetine, milnacipran, moclobemide, and pirlindole. ... Pay-Per-View - Clinical Psychiatry News - HighBeam Research

APPETITE SUPPRESSANT, SYMPATHOMIMETIC (Oral route).(Drug …  -  May 1, 2007
Moclobemide * Nialamide * Pargyline * Phenelzine * Procarbazine * Selegiline * Sibutramine * Toloxatone * Tranylcypromine Using medicines in this class with ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Psychiatric Times. The Light-er Side of Treating Seasonal Affective …  -  Oct 1, 2005
There are some very limited controlled data suggesting moclobemide (Aurorix) may be effective (Lingjaerde et al., 1993; Partonen and Lonnqvist, 1996). Psychiatric Times

Swiss pharma major Roche has sold four of its established products to...  -  Sep 8, 2008
Marcoumar (phenprocoumon); loop diuretic Torero (torasemide); NSAID Tilcotil (tenoxicam); and MAO-A inhibitor and antidepressant Aurorix (moclobemide), ... Pay-Per-View - Chemistry and Industry - HighBeam Research

Controlled (S8)(AU) Class A(UK) Schedule II(US)  -  Aug 1, 2006
Pethidine has serious interactions that can be dangerous with MAOIs (eg furazolidone, isocarboxazid, moclobemide, phenelzine, procarbazine, selegiline, ... chemie.de

Depression, anxiety and NICE guidance: where GPs stand now.  -  Sep 17, 2005
Other alternatives include moclobemide, reboxetine and tricyclic antidepressants (lofepramine). Sertraline is the drug of choice for patients with a recent ... Free with registration - Pulse - AccessMyLibrary.com

European Experts Agree on Nine Evidence-Based Recommendations for …  -  Aug 21, 2007
Antidepressants - amitriptyline, fluoxetine, duloxetine, milnacipran, moclobemide, and pirlindole - often improve Fibromyalgia patient function and reduce ... ProHealth

Fluvoxamine (Systemic).  -  Aug 1, 2006
Sinemet) or Lithium (eg, Eskalith) or Meperidine (eg, Demerol) or Moclobemide (eg, Manerex) or Nefazodone (eg, Serzone) or Pentazocine (eg, ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

ANTIHISTAMINE (Oral route, Parenteral route, Rectal route).(Drug …  -  May 1, 2007
Moclobemide * Nefazodone * Nelfinavir * Nialamide * Nortriptyline * Octreotide * Pargyline * Pentamidine * Phenelzine * Pimozide * Pirmenol * Posaconazole ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Responsiveness of 5-H[T.sub.1A] and 5-H[T.sub.2] receptors in the rat...  -  Jul 1, 2005
...but not by the monoamine oxidase type A inhibitor moclobemide or electroconvulsive shocks, the latter 2 of which are ineffective in OCD. (11,12) ... Free with registration - Journal of Psychiatry and Neuroscience - AccessMyLibrary.com

Kava.  -  May 1, 2006
Medicines used to treat depression or Parkinson's disease (examples: moclobemide (Manerix(R)); phenelzine (Nardil(R)); selegiline (Deprenyl(R), Eldepryl(R)) ... Free with registration - AltCareDex Alternative Medicines - AccessMyLibrary.com

Understanding Comorbid Depression and Anxiety  -  Dec 1, 2007
The results of another study that compared the SSRI paroxetine with the MAOI moclobemide showed that the SSRI was more beneficial for patients with ... Psychiatric Times

Gli antidepressivi SSRI non aumenterebbero il rischio di sanguinamento...  -  Oct 26, 2008
...trimipramina, maprotilina**, trazodone, mianserina, amoxapina**, bupropione, doxepina, moclobemide e nefazodone** il gruppo a bassa affinità. ... Pillole.org

European group issues fibromyalgia guidelines.(Pain Medicine)  -  Nov 1, 2007
Other antidepressants that have shown benefits in varying numbers and sizes of trials were fluoxetine, duloxetine, milnacipran, moclobemide, and pirlindole. ... Free with registration - Clinical Psychiatry News - AccessMyLibrary.com

Tips Praktis Mengenali Fobia Sosial  -  Mar 5, 2008
Saat ini tersedia RIMA (Reversible Inhibitor of Monoamine Oxidase A), misalnya: Moclobemide (Aurorix®). Dosisnya 450 mg per hari. ... Kabar Indonesia

Vulnerability for apoptosis in the limbic system after myocardial...  -  Jan 1, 2007
...(19) Fluoxetine (a selective 5-hydroxytryptamine [HT] uptake inhibitor) and moclobemide (a monoamine oxidase-A inhibitor) are antidepressant drugs known to ... Free with registration - Journal of Psychiatry and Neuroscience - AccessMyLibrary.com

Press Release: New insight into potential cause of sexual dysfunction...  -  May 26, 2005
Antidepressant-induced sexual dysfunction during treatment with moclobemide ... antidepressant-induced sexual dysfunction have been inconsistent due ... ... Pay-Per-View - M2 Presswire - HighBeam Research

COLUMN OFER: Bijsluiter  -  Jun 23, 2008
...behandeling met zogenaamde monoamine-oxidase (MAO-)remmers zoals selegiline (bij de ziekte van Parkinson) of moclobemide (tegen neerslachtigheid). ... Yord.nl

Article: Narrative literature review: sexual dysfunction in the...  -  Nov 1, 2006
Antidepressant-induced sexual dysfunction during treatment with moclobemide ... antidepressant-induced sexual dysfunction have been inconsistent due ... ... Pay-Per-View - Nephrology Nursing Journal - HighBeam Research

Article: Sex park's new dimension to rollercoaster relationships.(News...  -  Oct 8, 2005
Antidepressant-induced sexual dysfunction during treatment with moclobemide ... antidepressant-induced sexual dysfunction have been inconsistent due ... ... Pay-Per-View - Daily Post - HighBeam Research

Many migraine patients at risk for serotonin syndrome.(Neurology) | …  -  Dec 1, 2007
...especially the monoamine oxidase inhibitors moclobemide and pirlindole, to induce a serotonin syndrome," Dr. Bennett explained in an interview. ... Pay-Per-View - Internal Medicine News - HighBeam Research

Article: NSW: Police link two deaths to drug cocktail, and maybe a...  -  Nov 13, 2006
He died from serotonin syndrome after taking the anti-depressants moclobemide and venlafaxine, a post-mortem examination concluded. ... Pay-Per-View - AAP General News - HighBeam Research

Neuroscience; Increasing attention has provided information about...  -  Jan 29, 2005
They continued, "Moclobemide has been the most widely studied but produced unconvincingly therapeutic effects on social phobic symptoms. ... Pay-Per-View - Obesity, Fitness & Wellness Week - Factiva, from Dow Jones

Article: Low DHEA level doubles sexual dysfunction risk.(Women's...  -  Mar 15, 2007
Antidepressant-induced sexual dysfunction during treatment with moclobemide ... antidepressant-induced sexual dysfunction have been inconsistent due ... ... Pay-Per-View - Internal Medicine News - HighBeam Research

Neuroscience; Increasing attention has provided information about...  -  Jan 24, 2005
They continued, "Moclobemide has been the most widely studied but produced unconvincingly therapeutic effects on social phobic symptoms. ... Pay-Per-View - Health & Medicine Week - Factiva, from Dow Jones

Alembic gets US FDA approval for its API facility at Panelav.  -  May 19, 2005
...has to date made Drug Master Files for venlafaxine HCL, Leflunomide, Fenofibrate, Modafinil, Cilostazol, Azithromycin monohydrate and Moclobemide. ... Pay-Per-View - Express Pharma Pulse - Factiva, from Dow Jones

Article: Methadone's impact on libido hurts compliance: between 30%...  -  May 1, 2005
Antidepressant-induced sexual dysfunction during treatment with moclobemide ... antidepressant-induced sexual dysfunction have been inconsistent due ... ... Pay-Per-View - Clinical Psychiatry News - HighBeam Research

Article: Problem Page: My partner insists on wearing my underpants.( …  -  Feb 2, 2006
Antidepressant-induced sexual dysfunction during treatment with moclobemide ... antidepressant-induced sexual dysfunction have been inconsistent due ... ... Pay-Per-View - Daily Record - HighBeam Research

Article: NT: Man accused of gang raping boy had sexual dysfunction - ...  -  Feb 22, 2007
Antidepressant-induced sexual dysfunction during treatment with moclobemide ... antidepressant-induced sexual dysfunction have been inconsistent due ... ... Pay-Per-View - AAP General News - HighBeam Research

Article: Sexual dysfunction after stopping OCs explained.(Oral …  -  Mar 15, 2006
Antidepressant-induced sexual dysfunction during treatment with moclobemide ... antidepressant-induced sexual dysfunction have been inconsistent due ... ... Pay-Per-View - Internal Medicine News - HighBeam Research

Article: Problem Page: Sleeping situation is driving us apart.(Feature...  -  Jan 18, 2006
Antidepressant-induced sexual dysfunction during treatment with moclobemide ... antidepressant-induced sexual dysfunction have been inconsistent due ... ... Pay-Per-View - Daily Record - HighBeam Research

Le moclobémide est un antidépresseur efficace chez le sujet âgé …  -  May 12, 2006
Moclobemide in elderly patients with cognitive decline and depression. An international double-blind, placebo-controlled trial. ... EBM Journal (Abonnement)

메디팜뉴스 - ì?˜ì•½ì „문 1등 ì?¸í„°ë„· 신문 (주소창ì—? 한글로 '메디팜뉴스'를...  -  Dec 28, 2007
...혈액장애, 발작 등 중대한 ��반�)�sparfloxacin(QT 연장, 심실성 빈맥, 심실 세� � torsadesde points 등 심�성위험 �가)�moclobemide(근�성, 간질, ... 메디팜뉴스

불안장애ì—? 효과ì ?ì?¸ 약물요법  -  Jun 23, 2005
...사회공��(대�공��)� 대해 ���서는 선�� 모노아민옥시다제억제제(MAO)� moclobemide, 선�� 세로토닌재�수억제제(SSRI)� 염산 파�세틴수화물과 �스시 ... 메디칼트리뷴

La fibromialgia è multidisciplinare  -  Sep 26, 2007
...(SNRI, inibitore reuptake serotonina e noradrenalina) come duloxetina e milnacipram, anti-MAO (monoaminossidasi) come moclobemide e pirlindolo; ... Dica 33

kiesBeter.nl - Medicijnen, Depressie  -  Sep 27, 2005
Voorbeeld is moclobemide. Sint-janskruid is een kruidenmiddel met een antidepressieve werking. Hoe het precies werkt, is nog niet helemaal bekend. ... kiesbeter.nl

Brand Names/Synonyms:
Moclobemide is also known by the following brand names and/or synonymsAurorix; CHEMBANK1633; HSDB 7180; Manerix; Moclaime; Moclamide; Moclobemid; Moclobemida [Inn-Spanish]; Moclobemide; Moclobemide [Usan:Ban:Inn]; Moclobemidum [Inn-Latin]; Modobemde

Drug Category:
Moclobemide is categorized under the following by the FDA: Antidepressants; Antidepressants; ATC:N06AG02

Dosage Forms:
TABLET

Absorption:
Not Available

Interactions:
Not Available



Chemical IUPAC Name:
4-chloro-N-(2-morpholin-4-ylethyl)benzamide





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