Modafinil

This page contains recent news articles, when available, and an overview of Modafinil but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Modafinil
(when available)

Pharmacology and use:
Modafinil is a stimulant drug marketed as a 'wakefulness promoting agent' and is one of the stimulants used in the treatment of narcolepsy. Narcolepsy is caused by dysfunction of a family of wakefulness-promoting and sleep-suppressing peptides, the orexins, whose neurons are activated by modafinil. The prexin neuron activation is associated with psychoactivation and euphoria. Modafinil is not indicated for complaints of lack of energy or fatigue; but it appears to be very helpful for some patients. Also, it has been used in the treatment of hypersomnia, a disorder in which patients lack the capacity for meaningful sleep and may require ten or more hours per day. Recent studies have have found that modafinil may help recovering cocaine addicts fight their addiction. To improve wakefulness in patients with excessive daytime sleepiness (EDS) associated with narcolepsy

Mechanism Of Action:
The exact mechanism of action is unclear, although in vitro studies have shown it to inhibit the reuptake of dopamine by binding to the dopamine reuptake pump, and lead to an increase in extracellular dopamine. Modafinil activates glutamatergic circuits while inhibiting GABA. Modafinil is thought to have less potential for abuse than other stimulants due to the absence of any significant euphoric or pleasurable effects. It is possible that modafinil acts by a synergistic combination of mechanisms including direct inhibition of dopamine reuptake, indirect inhibition of noradrenalin reuptake in the VLPO and orexin activation. Modafinil has partial alpha 1B-adrenergic agonist effects by directly stimulating the receptors.

News Articles on Modafinil

Neuro-Enhancement: Das Gehirn ist kein Muskel  -  05 Jan 2010
Indes war nicht allen Kommentatoren aufgefallen, dass die Verfasser des Memorandums heute verfügbare Substanzen wie Ritalin und Modafinil aus ihren ... FAZ - Frankfurter Allgemeine Zeitung

文化鴻æº?:變è?°æ˜Žçš„æ?·å¾‘  -  05 Jan 2010
...她說有研究顯示這些藥當中的一些興奮劑存在上癮的å?¯èƒ½æ€§ï¼Œä¸?é?Žå…¶ä»–一些,譬如原來是為了治療日間嗜ç?¡ç—…患者的莫é?”é?žå°¼ï¼ˆModafinil),å?»ä¼¼ä¹Žæ²’有æˆ?癮的å?±éšªã€‚ ... BBC中文網

文化鸿沟:å?˜è?ªæ˜Žçš„æ?·å¾„  -  05 Jan 2010
...她说有研究显示这些è?¯å½“中的一些兴奋剂存在上瘾的å?¯èƒ½æ€§ï¼Œä¸?过其他一些,譬如原æ?¥æ˜¯ä¸ºäº†æ²»ç–—日间嗜ç?¡ç—…患者的莫达é?žå°¼ï¼ˆModafinil),å?´ä¼¼ä¹Žæ²¡æœ‰æˆ?瘾的å?±é™©ã€‚ ... BBC 中文网

It's a no-brainer – bring on the pills that will make us smarter  -  ‎Jan 2, 2010‎
Sahakian made no secret of the fact that some of her scientific colleagues regularly use cognitive enhancers — such as modafinil — to deal with jet lag, ... Times Online

Former Olympic Gold Medalist Homeless  -  ‎Dec 11, 2009‎
Harrison's fall started when he tested positive for the stimulant Modafinil in 2004, and was subsequently suspended from athletic competition. ... Huffington Post (blog)

Four plead innocent to drug or forgery charges  -  ‎Jan 1, 2010‎
Authorities found 110 syringes, spoons with white residue and 807 pills in the master bedroom, including tablets of hydrocodone and modafinil, ... Daily Inter Lake

Ten Emerging Technology Trends of the Next Ten years  -  ‎Dec 29, 2009‎
Drugs like ritalin, donepezil and modafinil are increasingly being used by students, academics and others to give them a mental edge. ... Institute for Ethics and Emerging Technologies

FDA Approval For Jetlag Drug Delayed  -  ‎Jan 1, 2010‎
Nuvigil (armodafinil) is a follow-on version of Provigil (modafinil) which contributed about 50% to revenues in 2008. Cephalon received FDA approval for ... MedIndia

Cephalon Provides Update on Regulatory Review of NUVIGIL for the Treatment of ...  -  ‎Dec 22, 2009‎
NUVIGIL, the longer-lasting isomer of modafinil, was launched in the United States in June 2009. It is indicated to improve wakefulness in patients with ... PipelineReview.com (press release)

Court Report  -  ‎Dec 20, 2009‎
2002) and 7132570 ("Method for the Production of Crystalline Forms of Optical Enantiomers of Modafinil," issued November 7, 2006) following a Paragraph ... Patent Docs (blog)

Tired of Being Tired?Cancer-related fatigue doesn't have to slow you down.  -  ‎Dec 23, 2009‎
Stimulants such as Ritalin (methylphenidate), a treatment for attention deficit disorder, and Provigil (modafinil), which is approved for narcolepsy, ... Curetoday.com (press release)

Research from University of California in the area of depression quality of ...  -  ‎Dec 17, 2009‎
...(1974-2009) using key terms 'quality of life,' 'major depression,' and 'major depressive disorder,' and 'dopaminergic,' 'bupropion,' or 'modafinil. ... Behavioral Health Central (blog)

Health column: Narcolepsy not well understood  -  ‎Dec 13, 2009‎
Certain stimulant medications (for example modafinil) and/or certain anti-depressant medications may be prescribed. Importantly, the patient's teachers, ... Brookline TAB

Cephalon, Inc. - Pharmaceuticals & Healthcare - Deals and Alliances Profile ...  -  ‎Dec 29, 2009‎
The product portfolio of the company includes modafinil tablets, fentanyl buccal tablets, arsenic trioxide injections, oral transmucosal fentanyl citrate ... PRMinds (press release)

By: Zacks Equity Research  -  ‎Dec 11, 2009‎
Nuvigil (armodafinil) is the follow-on version of Provigil (modafinil), which contributed about 50% to revenues in 2008. With Provigil slated to face ... Zacks.com

Teen marijuana use on the rise  -  ‎Dec 16, 2009‎
The other drug added to the study in 2009 is Provigil (modafinil), which is a prescription-controlled medicine for improving wakefulness. ... Spero News

Mit Pillen schneller arbeiten  -  ‎Dec 22, 2009‎
Besser dokumentiert ist da schon der stimulierende Effekt von Modafinil, das gegen die Schlafkrankheit Narkolepsie verschrieben wird. ... FR-online.de

Αστεγος Ολυμπιονίκης  -  ‎Dec 15, 2009‎
Οι δοκιμασίες του άÏ?χισαν το 2004, όταν «συνελήφθη» για χÏ?ήση της διεγεÏ?τικής ουσίας Modafinil. Η διετής τιμωÏ?ία τοÏ? στέÏ?ησε τη συμμετοχή στους ΟλυμπιακοÏ?Ï‚ ... Έθνος

Farmakologiczne wspomaganie możliwoÅ›ci mózgu może być puÅ‚apkÄ…  -  ‎Dec 13, 2009‎
W stanach wyczerpania na przykład pomaga modafinil, wynaleziony we Francji w latach 70. Pierwotnie stosowany był w leczeniu narkolepsji. ... Rynek Zrdowia

La neurologie cosmétique  -  ‎Dec 11, 2009‎
Modafinil, ritaline ou donépézil, des médicaments utiles pour le traitement de grands désordres; dans l'ordre: la narcolepsie, les troubles de l'attention ... Radio Suisse Romande

Hirn: Der alte Fuchs  -  ‎Dec 30, 2009‎
Seit Methylphenidat (besser bekannt als "Ritalin"), Donezepil und Modafinil in Unternehmen und Universitäten angekommen sind, haben Kaffee und Co. ... Welt Online

Eko eller artificiellt blir 10-talets frÃ¥ga  -  ‎Dec 29, 2009‎
Men framför allt har jag morgonstundens guld att tacka modafinil, ett prestationshöjande preparat som minskar sömnbehovet utan att påverka ... Expressen

Hjernedop skaper hodebry  -  ‎Dec 24, 2009‎
Allerede i dag får soldater i flere land stoffer som amfetamin og modafinil for å bli mer årvåkne. Hvis soldatene får ordre om det, er de ofte lovpålagt å ... forskning.no

No Dope, no Hope  -  ‎Dec 22, 2009‎
Darunter fallen Medikamente, die – wie Modafinil (Markenname: Vigil) – gegen Narkolepsie und – wie Donepezil – zur Gedächtnisstärkung bei Dementen und ... Jungle World

Boost je blok: studiebevorderende middelen  -  ‎Dec 13, 2009‎
Minder bekende namen zijn Provigil (op basis van modafinil) en Strattera (op basis van atomoxetine). Het eigenlijke gebruik van deze middelen dient onder ... Veto

Doping am OP-Tisch?  -  ‎Dec 13, 2009‎
Genauer geht es um Modafinil oder Methylphenidat (als Ritalin bekannt), die für die Therapie von krankhaftem Schlafdrang oder Aufmerksamkeitsdefiziten ... Neues Deutschland

Mayo Clinic Proceedings Publishes Study of NUVIGIL in Patients with Shift Work ...  -  ‎Nov 2, 2009‎
NUVIGIL, the longer-lasting isomer of modafinil, is indicated to improve wakefulness in patients with excessive sleepiness associated with shift work ... Reuters

Smart Pills: More Focus or Hocus Pocus?  -  ‎Oct 29, 2009‎
They also include Provigil (modafinil), the drug used off-label to keep pilots alert and approved to treat narcolepsy and sleep apnea. ... HealthNewsDigest.com

Cephalon Net Sales Increase 9% and Net Cash from Operations Surpasses $200 ...  -  ‎Oct 27, 2009‎
...$24.0M in 2008), accelerated depreciation related to restructuring ($5.0M in 2009; $4.5M in 2008) and the reserve for modafinil purchase commitments in ... Reuters

Pivotal Data Published in the Journal Cancer Demonstrate that TREANDA Induced ...  -  ‎Nov 5, 2009‎
PROVIGIL® (modafinil) Tablets [C-IV] and ACTIQ® (oral transmucosal fentanyl citrate) [C-II]. The company also markets numerous products internationally. ... Reuters

Cephalon, Inc. to Webcast R&D Day  -  ‎Nov 4, 2009‎
PROVIGIL® (modafinil) Tablets [C-IV], TRISENOX® (arsenic trioxide) injection, GABITRIL® (tiagabine hydrochloride) and ACTIQ® (oral transmucosal fentanyl ... Reuters

Stakeholder Opinions - Narcolepsy - Entry-point to a lucrative fatigue ...  -  ‎Oct 23, 2009‎
The narcolepsy market value has grown considerably since 2004 to reach $230m in 2007 driven largely by the significant penetration of Provigil (modafinil; ... PR-Inside.com (Pressemitteilung)

Cephalon Appoints Bob Repella as Senior Vice President of U.S. Pharmaceutical ...  -  ‎Oct 27, 2009‎
...trioxide) injection, GABITRIL® (tiagabine hydrochloride), PROVIGIL® (modafinil) Tablets [C-IV], and ACTIQ® (oral transmucosal fentanyl citrate) (C-II). ... Reuters

An Alternative To Adderall?  -  ‎Oct 27, 2009‎
Ritalin and Modafinil that were developed to treat ADD/ADHD) to keep up with their highly stressful, extremely demanding daily routines. ... PR Web (press release)

We Are Neuroscientists and We Come in Peace  -  ‎Oct 18, 2009‎
UK, cited recent evidence that the use of cognitive-enhancing drugs such as modafinil is increasing among teenagers, raising questions about long-term ... Science Magazine (blog)

Cephalon, Inc. - Pharmaceuticals & Healthcare - Deals and Alliances Profile ...  -  ‎Nov 9, 2009‎
The product portfolio of the company includes modafinil tablets, fentanyl buccal tablets, arsenic trioxide injections, oral transmucosal fentanyl citrate ... PR-Inside.com (Pressemitteilung)

Cephalon Net Sales Increase 9% and Net Cash from Operations Surpasses $200 ...  -  ‎Oct 28, 2009‎
TREANDA® for Injection, FENTORA® (fentanyl buccal tablet) [C-II], PROVIGIL® (modafinil) Tablets [C-IV], TRISENOX® (arsenic trioxide) injection, ... PharmaLive.com (press release)

Cephalon Appoints Bob Repella as Senior Vice President of US Pharmaceutical ...  -  ‎Oct 27, 2009‎
GABITRIL(R) (tiagabine hydrochloride), PROVIGIL(R) (modafinil) Tablets [C-IV], and ACTIQ(R) (oral transmucosal fentanyl citrate) (C-II). ... Trading Markets (press release)

“è?ªæ˜Žè?¯â€?æ?¥äº†ï¼Ÿä¸€ç»?问世就陷入争议漩涡  -  ‎Nov 5, 2009‎
...利他林(ritalin,一ç§?中枢兴奋è?¯ï¼‰ï¼Œä»¥ä¾¿ç†¬å¤œå¥‹æˆ˜ï¼›æ€¥èµ¶è¿›åº¦çš„软件工程师,或想ä¿?æŒ?æ•?é”?头脑的ä¼?业管ç?†äººå‘˜ï¼Œåˆ™ä¼šæœ?用几粒莫达é?žå°¼ï¼ˆmodafinil,新一代兴奋剂)。 ... 新华网

Psychotherapeuten kritisieren «Hirndoping»  -  ‎Nov 11, 2009‎
So ließen sich die Risiken eines unkontrollierten und andauernden Konsums der Amphetamine Methylphenidat und Modafinil bei Gesunden noch gar nicht ... Pharmazeutische Zeitung online

Ärzte warnen vor Hirndoping  -  ‎Nov 11, 2009‎
Reiner Richter, sprach sich kürzlich deutlich gegen frei verkäufliche Medikamente" und dann "Amphetaminverwandte Produkte wie Methylphenidat und Modafinil ... ShortNews.de

“è?ªæ˜Žè?¯â€?真有效å?—?  -  ‎Nov 10, 2009‎
...å?ˆæ³•的精神兴奋剂包括苯哌啶醋酸甲酯(methylphenidate,å?³åˆ©ä»–æž—)ã€?安é?žä»–明(amphetamine)å?ŠèŽ«è¾¾é?žå°¼(modafinil)。æ?®æŠ¥é?“,在æŸ?些学校,1/4的学生都在æœ?用这些è?¯ç‰©ã€‚ ... 中青在线

大学生和白领æµ?行å?ƒçš„“è?ªæ˜Žè?¯â€?真有效?  -  ‎Nov 9, 2009‎
...å?ˆæ³•的精神兴奋剂包括苯哌啶醋酸甲酯(methylphenidate,å?³åˆ©ä»–林)ã€?安é?žä»–明(amphetamine)å?ŠèŽ«è¾¾é?žå°¼ï¼ˆmodafinil)。æ?®æŠ¥é?“,在æŸ?些学校,1/4的学生都在æœ?用这些 ... 人民网

Psychotherapeuten warnen vor IQ-Doping  -  ‎Nov 11, 2009‎
Die Risiken eines unkontrollierten, weit verbreiteten und andauernden Konsums von Amphetamin-Abkömmlingen wie Methylphenidat und Modafinil seien noch gar ... ZEIT ONLINE

Au travail, à l'école, au lit… bientôt, tous dopés !  -  ‎Nov 2, 2009‎
Commercialisée en France sous le nom de Modiodal et aux Etats-Unis sous celui de Provigil, la molécule anti-sommeil modafinil est un succès : ses ventes ont ... Viva Presse

Zweijährige Dopingsperre für Vincenzo Centrone  -  ‎Oct 20, 2009‎
Juni positiv auf die Substanz Modafinil getestet. Modafinil ist eine stimulierende Substanz, die von der Welt-Anti-Doping-Agentur für Wettkämpfe verboten ... Luxemburger Wort

Debatte um «Glückspillen»: Wie verbreitet ist Nerven-Doping tatsächlich?  -  ‎Oct 21, 2009‎
Für Aufregung sorgte 2008 eine Umfrage des Fachblattes Nature: Jeder fünfte der befragten akademischen Leser gab an, schon Ritalin, Modafinil oder ... news.de

Centrone prend deux ans  -  ‎Oct 21, 2009‎
Il venait alors d'apprendre que du Modafinil, un stimulant et un coupe-faim, avait été détecté dans l'échantillon A prélevé à l'issue de la course qui ... Le Quotidien

Doping gegen Stress und Leistungsdruck  -  ‎Oct 27, 2009‎
Methylphenidat, Modafinil, Piracetam, Fluoxetin oder Metoprolol heißen die Wirkstoffe, die auf der Dopingliste der Deutschen Angestellten Krankenkasse (DAK) ... Usinger Anzeiger

Nur mit Pille ins Büro  -  ‎Nov 10, 2009‎
Sie schlucken Mittel wie etwa Fluoxetin, Metoprolol oder Modafinil, obwohl sie gar nicht die Krankheiten plagen, für die diese Wirkstoffe eigentlich ... Frankfurter Rundschau

Lernen ist das beste Hirndoping  -  ‎Nov 3, 2009‎
Neuro-Enhancer wie Levodopa, Modafinil oder Ritalin wirken nicht als Gehirndoping, wie dies in den populären Medien häufig behauptet wird. ... ETH Life online

Gehirndoping: Psychotherapeuten warnen  -  ‎Nov 11, 2009‎
Zu den umstrittenen Mitteln gehören laut Richter Amphetamine und ihre Derivate wie etwa Methylphenidat oder Modafinil sowie Antidepressiva, ... Deutsches Ärzteblatt

ç’°ç?ƒç§‘學:è?°æ˜Žè—¥æƒ¹è³ªç–‘(組圖)  -  ‎Nov 6, 2009‎
...å?ˆæ³•的精神興奮劑包括苯呱啶醋酸甲酯(methylphenidate,å?³åˆ©ä»–æž—)ã€?安é?žä»–明(amphetamine)å?ŠèŽ«é?”é?žå°¼(modafinil)。據報導,在æŸ?些學校,1/4的學生都在æœ?用這些藥物。 ... 臺灣新浪網

Auf dem Weg zur Doping-Gesellschaft?  -  ‎Oct 20, 2009‎
Bei Modafinil wurde unter Schlafentzug ein positiver Effekt auf die Wachheit und Aufmerksamkeit gefunden, aber auch eine Tendenz zur Selbstüberschätzung. ... NZZ Online

Gehirndoping: Leistung als Tablette  -  ‎Nov 11, 2009‎
Zu den Aufputschmitteln zählen laut Rainer Richter Amphetamine und ihre Derivate wie etwa Methylphenidat oder Modafinil sowie Antidepressiva, ... Pierre Markuse

è?ªæ˜Žè?¯è®©å¤§è„‘快速充电?  -  ‎Nov 4, 2009‎
...熬夜的大学生ç»?常会å?‘朋å?‹ç´¢è®¨å¤„æ–¹è?¯åˆ©ä»–ç?µ(Ritalin)ï¼›é?¢å¯¹æœŸé™?压力的程åº?设计师或想维æŒ?æ€?è·¯æ•?æ?·çš„ä¼?业ç»?ç?†äººï¼Œåˆ™ä¼šæœ?用新一代的æ??神è?¯èŽ«å¾…èŠ¬å®?(modafinil)。 ... 中新网

Ex-Radprofi : Nicht nur Profi-Sportler dopen  -  ‎Oct 27, 2009‎
Jahre wirft sich beispielsweise jeder fünfte Professor und Student nicht indizierte Arzneimittel wie Ritalin oder Modafinil zur Leistungssteigerung ein. ... Saarbrücker Zeitung (Abonnement)

è?°æ˜Žè—¥å¹«å¤§è…¦å¿«é€Ÿå……電?  -  ‎Oct 28, 2009‎
...熬夜的大學生經常會å?‘朋å?‹ç´¢è¨Žè™•方藥利他é?ˆï¼ˆRitalin);é?¢å°?期é™?壓力的程å¼?設計師或想維æŒ?æ€?è·¯æ•?æ?·çš„ä¼?業經ç?†äººï¼Œå‰‡æœƒæœ?用新一代的æ??神藥莫待芬寧(modafinil)。 ... 科學人雜誌 (需訂閲)

Stevens-johnson syndrome  -  ‎Oct 23, 2009‎
...barbiturates, sulfonamides, phenytoin, azithromycin, modafinil[3], lamotrigine, nevirapine, ibuprofen[4], ethosuximide, carbamazepine)a tiez NSAID radu. ... Zdravie.sk

Memorandum zur Glückspille: Die wichtigsten Thesen  -  ‎Oct 21, 2009‎
Was würde passieren, wenn in Zukunft wirklich eine nebenwirkungsfreie «Glückspille» zur Verfügung stünde? Sieben Mediziner, Philosophen und Juristen ... news.de

FDA Committee Rejects ADHD use for Modafinil  -  Mar 24, 2006
...by Jon Hamilton. A Food and Drug Administration advisory committee decides not to recommend approval of a new drug for children with attention deficit ... NPR

Narcolepsy Drug May Treat Cocaine Addiction  -  Apr 25, 2006
In addition to blunting cocaine's notorious cravings, modafinil might also ... The main side effect so far: insomnia, not surprising as modafinil is sold ... FOXNews

Modafinil | Life and style | BMJ Group  -  Jul 25, 2008
We don't know. These tablets are used to treat an illness that makes you keep falling asleep (called narcolepsy) But more research is need to find out if ... guardian.co.uk

Sprinters say doctor helped get their drugs Bay Area psychiatrist...  -  Feb 21, 2005
He prescribed the drug Provigil (which contains modafinil) for this condition ...." ... He said he did not believe modafinil had been banned in her sport. ... San Francisco Chronicle

Drug May Help Combat 'Chemo Brain'  -  Jun 5, 2007
The small study involved the drug modafinil (Provigil), ... Modafinil belongs to a class of drugs called eugeroics, which stimulate the brain only as ... Washington Post

Narcolepsy Drug Eyed for Cocaine Users  -  Apr 24, 2006
In addition to blunting cocaine's notorious cravings, modafinil might also ... The main side effect so far: insomnia, not surprising as modafinil is sold ... Washington Post

Modafinil normalized hyperreflexia after spinal transection in adult...  -  Dec 16, 2008
Correspondence: Dr E Garcia-Rill, Center for Translational Neuroscience, Department of Neurobiology and Developmental Sciences, Slot 847, University of ... Nature.com

Modafinil for sleep apnea  -  Jul 13, 2007
Modafinil or armodafinil is taken as a pill once a day to decrease sleepiness during the day. Modafinil and armodafinil work by affecting chemicals in the ... WebMD

Drug may help addicts kick cocaine.  -  Jan 11, 2005
Addicts who took modafinil _ used to treat narcolepsy and help pilots and ... Modafinil, he said, has qualities that could "propel it to the top. ... Free with registration - Philadelphia Inquirer - AccessMyLibrary.com

Ginseng, Donepezil, and Modafinil for Fatigue in Cancer Patients  -  Jun 4, 2007
June 4, 2007 (Chicago) — Some of the new studies with ginseng, donepezil, and modafinil for the treatment of fatigue in cancer patients presented here at ... Medscape

Trial of Modafinil for Cocaine Dependence  -  Feb 25, 2005
Correspondence: Dr DF Umanoff, National Association for the Advancement and Advocacy of Addicts, Inc., 8779 Misty Creek Dr., Sarasota, Fl 34241, USA. ... Nature.com

Doctor in BALCO steroids scandal could lose license  -  Sep 8, 2006
After KW tested positive for modafinil in August 2003, Halevie-Goldman sent a letter to her agents saying he had dispensed modafinil samples to treat her ... ESPN

Printer Friendly  -  Jul 20, 2008
There's a buzz about modafinil, meant to make you brighter and more energized. ... I plump for cheapo Modafinil. My sister, a doctor, phones with a warning: ... Times Online

Does modafinil safely and effectively treat shift-work sleep disorder?  -  Dec 5, 2005
Czeisler CA et al. (2005) Modafinil for excessive sleepiness associated with shift-work sleep disorder. N Engl J Med 353: 476–486 PubMed ... Nature.com

Drugs may boost your brain power  -  Apr 16, 2007
One of these drugs, Modafinil, was developed to treat people who ... With Modafinil they seemed to think a bit longer and they were more accurate." ... BBC News

Narcolepsy Treatment - Narcolepsy Health Information - NY Times Health  -  Sep 9, 2008
Modafinil . Modafinil (Provigil) is a drug used to treat the excessive ... Patients who switch to modafinil from stimulants such as methylphenidate have few ... New York Times

hysterectomy Removing ovarie ...  -  Aug 9, 2005
After three months, 74 percent of the modafinil group reported at least minimal ... However, the modafinil group continued to be excessively sleepy and ... Pay-Per-View - Washington Post - ProQuest Archiver

Feds Probe Pilot's Drug Use  -  Jan 18, 2008
But a person familiar with the case, speaking on condition of anonymity because the investigation is still going on, said Cota was taking modafinil. ... FOXNews

BALCO investigation: Key players  -  Apr 27, 2006
Does not include doping cases not related to BALCO, THG or modafinil. ... Though modafinil offenses in 2003 carried lesser penalties, his ban was set at two ... USA Today

Track Coach Agrees With USADA to Quit  -  Mar 13, 2007
Korchemny, sentenced to probation in the Balco case for supplying modafinil, essentially was retired before agreeing he will not participate with any ... Washington Post

Professor Recounts Life With Narcolepsy  -  May 16, 2005
And drugs such as modafinil have given doctors the ability to treat ... He increased my dosage of modafinil, added Ritalin, and told me I now needed nine ... FOXNews

Hidden dangers of failure to diagnose ADHD correctly  -  Apr 1, 2006
Modafinil should not be addictive, but the FDA's advisers were concerned about a case of a serious skin condition in a clinical trial, and have asked for ... New Scientist

Sleep drug can halve ice addicts' cravings  -  Dec 1, 2007
Modafinil prevents nerve cells from re-absorbing dopamine once they ... About 12 weeks after the trial, those who had been given modafinil were using ice ... Sydney Morning Herald

Narcolepsy - Overview - NY Times Health  -  Feb 15, 2008
The stimulant modafinil has less potential for addiction than older amphetamines. Sodium oxybate, or Xyrem, the potent sedative approved as a narcolepsy ... New York Times

Korchemny pleads guilty in BALCO scandal  -  Jul 29, 2005
...carries a maximum one-year sentence. The modafinil, and other drugs he was accused of giving his clients, was obtained from Conte, according to prosecutors. USA Today

Health Canada Endorses Safety Information on Modafinil (Alertec)  -  Dec 21, 2007
OTTAWA, CANADA -- December 21, 2007 -- Shire Canada Inc., in consultation with Health Canada, is releasing new warnings concerning modafinil (Alertec). ... DG News

Cephalon Hopes to Ease FDA Fears  -  Apr 18, 2006
Sparlon contains modafinil, the same ingredient in Provigil, a sleep-disorders drug that's ... Sparlon has a higher dose of modafinil than Provigil does. ... TheStreet.com - TheStreet.com (subscription)

White treated 'like a guinea pig'  -  May 18, 2005
..."I tried a lot of stimulants and modafinil suited me perfectly. ... White tested positive for modafinil at the 2003 World Championships in Paris and was ... BBC News

Vanda says drug does not show significant wakefulness  -  Oct 30, 2007
Modafinil treats narcolepsy, a condition that causes excessive daytime sleepiness, and shift work sleep disorder -- wakefulness that occurs in people who ... Reuters

Cephalon Drug May Be Delayed  -  Dec 7, 2006
Provigil also contains modafinil. The current label says post-marketing accounts have included "rare reports of serious skin reactions," including ... TheStreet.com - TheStreet.com (subscription)

Modafinil Is Effective In Treating Excessive Sleepiness  -  Oct 15, 2007
WESTCHESTER, IL -- October 15, 2007 -- Modafinil is well-tolerated in the treatment of excessive sleepiness associated with disorders of sleep and ... DG News

US study shows drug cuts overnight shift fatigue  -  Aug 4, 2005
Cephalon Inc.'s modafinil, sold under the brand Provigil, produced fewer ... Modafinil "gets patients about one-third of the way toward normalcy," said the ... Malaysia Star

The Ritalin express  -  Oct 23, 2008
Modafinil is also not available over the counter. So why are students taking them? Modafinil and Ritalin are drugs that stimulate the brain. ... BBC News

Just What Kids Need - Sparlon - Another ADHD Drug  -  Mar 20, 2006
Modafinil-based Provigil is currently only approved for narcolepsy, sleep apnea and shift ... Initial marketing of modafinil, Dr Dubose Ravenel concludes, ... scoop.co.nz

Cephalon wins US approval for Nuvigil sleep drug  -  Jun 18, 2007
Nuvigil is a version of modafinil, the active ingredient also in Cephalon's older drug, Provigil. In March, the company said the Food and Drug ... Reuters

Soviet coached Indians on drug use  -  Jul 30, 2005
Remi Korchemny, 73, admitted in US federal court that he had wrongly dispensed the prescription drug modafinil to an athlete on July 4, 2002. ... Expressindia.com

FDA panel: modafinil not safe for ADHD in children.(News)  -  May 1, 2006
GAITHERSBURG, MD. -- A Food and Drug Administration advisory committee said modafinil is not safe for treating ADHD in children and adolescents by a 12-1 ... Free with registration - Skin & Allergy News - AccessMyLibrary.com

Revised modafinil label cites psychiatric risks.(NEWS FROM THE FDA)  -  Jan 1, 2008
Warnings about serious rashes--including Stevens-Johnson syndrome and hypersensitivity reactions--as well as psychiatric symptoms have been added to the ... Free with registration - Clinical Psychiatry News - AccessMyLibrary.com

Investors bet on Cephalon drug, but risks abound  -  Mar 29, 2007
...severity of the warning, which is expected to also be added to the label for Provigil, since the two drugs share the same active ingredient: modafinil. ... Reuters

BALCO drug case ended up as track coach given probation  -  Feb 25, 2006
Korchemny last year admitted to a misdemeanor offense of wrongly dispensing a prescription drug, modafinil. The BALCO case, the biggest doping scandal ... 新�网

Cephalon says patent dispute is over  -  May 2, 2005
Cephalon Inc. said Monday it was notified by Sandoz Inc. that the company will no longer challenge Cephalon's US particle-size modafinil patent. ... Bizjournals.com

Modafinil (generic): Provigil (brand).(YOUR MEDICATION INFORMATION …  -  Jun 1, 2006
COMMON USAGE: Modafinil is used to improve wakefulness in patients with excessive daytime sleepiness associated with narcolepsy. It is also approved for use ... Free with registration - Brown University Child and Adolescent... - AccessMyLibrary.com

Chemobrain is for real  -  Feb 6, 2008
In the meantime preliminary trials of intervention to help chemobrain have shown some success with the narcolepsy drug modafinil (Modavigil) and with memory ... 6minutes

Cephalon: Wide Awake on Wall Street  -  Apr 2, 2007
...effects of skin rash and hypersensitivity in patients taking a combination of Nuvigil and a similar compound marketed by Cephalon, Provigil (modafinil). ... BusinessWeek

Modafinil (Systemic).  -  Jul 28, 2005
Modafinil (moe-DAF-i-nil) is used to help people who have narcolepsy, obstructive sleep apnea/hyponea, or shift work sleep disorder to stay awake during the ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Cephalon, Barr Ink Patent Deal  -  Feb 1, 2006
Barr also agreed to grant Cephalon a nonexclusive license, effective immediately, to certain worldwide intellectual property rights related to modafinil in ... TheStreet.com - TheStreet.com (subscription)

Modafinil Improves Cognitive Performance in Breast Cancer Survivors: ...  -  May 12, 2008
By Crina Frincu-Mallos, PhD. WASHINGTON, DC -- May 12, 2008 -- Modafinil therapy appears to improve memory and attention skills in breast cancer survivors ... DG News

Caraco close to OK on generic Provigil  -  Jul 20, 2007
..."Modafinil was filed with a paragraph IV certification that we do not infringe and or that the Cephalon patent is invalid. We were not sued by Cephalon. ... United Press International

Cephalon Receives Approval to Market Modafinil for Shift Work Sleep …  -  Aug 30, 2005
FRAZER, Pa., Aug. 30 /PRNewswire-FirstCall/ -- Cephalon, Inc. announced today that the company has received authorization from the Federal Institute for ... RedOrbit

Wheelchair player banned after failing drug test  -  Dec 21, 2006
An independent anti-doping tribunal ruled that the 27-year-old Frenchwoman did not intend to enhance her performance by taking adrafinil or modafinil, ... ESPN

Modafinil (Provigil) Will Carry Hypersensitivity Reaction Warning  -  Oct 25, 2007
By Peggy Peck, Executive Editor, MedPage Today. ROCKVILLE, Md., Oct. 25 -- The FDA said Cephalon has agreed to update the modafinil (Provigil) label to ... MedPage Today

Cephalon reaches another settlement over Provigil license  -  Dec 22, 2005
The companies also agreed to a business arrangements related to modafinil, Provigil's key active ingredient. Ranbaxy agreed to grant Cephalon a nonexclusive ... Bizjournals.com

Modafinil (Systemic).(Provigil drug overview)(Central nervous system ...  -  Aug 1, 2006
Modafinil (moe-DAF-i-nil) is used to help people who have narcolepsy, obstructive sleep apnea/hyponea, or shift work sleep disorder to stay awake during the ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Fears over drugs that can boost your brain  -  Apr 20, 2007
One of the drugs - modafinil - is licensed in the UK only to treat narcolepsy, ... It emerged last year that the UK military has tested modafinil and ... Daily Mail

… implications cited in new warnings for Modafinil (Provigil[R]).(Prof...  -  Feb 1, 2008
Dermatologic implications cited in new warnings for Modafinil (Provigil[R]).(Professional Practice) ... find Dermatology Nursing articles. Pay-Per-View - Dermatology Nursing - HighBeam Research

Tired professors take 'smart' pills to perk up lectures  -  Jul 15, 2007
Studies into the effects of Modafinil, an American drug, have shown it can improve mental ... Modafinil was created to help sufferers from sleep disorders. ... Times Online

Ranbaxy settles patent suit with Cephalon for sleep-disorder drug  -  Dec 24, 2005
Cephalon will also enter into arrangements with Ranbaxy related to supply of the active pharmaceutical ingredient modafinil. Mr Malavinder Mohan Singh, ... Hindu Business Line

Combination of Modafinil and Interferon-Beta-1a Appears Effective and...  -  Oct 1, 2006
By Bruce Sylvester. MADRID, SPAIN -- October 1, 2006 -- Adjunctive use of modafinil with interferon-beta-1a (Avonex) for breakthrough cognitive symptoms of ... DG News

Provigil (modafinil) Tablets - Warnings Added to Prescribing Informati...  -  Oct 24, 2007
BETHESDA, MD -- October 24, 2007 -- US Food and Drug Administration (FDA) and Cephalon notified healthcare professionals of Warnings added to prescribing ... DG News

Modafinil Improves Mental Well-Being in Patients with Brain Cancer  -  Jun 14, 2006
June 14, 2006 (Atlanta) — A drug used to treat sleep disorders has been found to improve cognitive function, mood, and fatigue in patients with brain tumors ... Medscape

White to WADA 'I was a guinea pig'; Sprinter tells panel she used...  -  May 19, 2005
I tried a lot of stimulants and modafinil suited me perfectly. ... White tested positive for modafinil at the 2003 world championships in Paris and was ... Pay-Per-View - Toronto Star - ProQuest Archiver

Modafinil for ADHD in children and adolescents.(What's New In...  -  Jun 1, 2006
The results of a 9-week, double-blind, placebo-controlled study suggest that treatment with a carefully designed dose of modafinil film-coated tablets ... Free with registration - Brown University Child and Adolescent... - AccessMyLibrary.com

Pediatric modafinil shows results in ADHD.(Behavioral Pediatrics)(Brie...  -  Jul 1, 2005
ATLANTA -- Results from new research point to a possible alternative to stimulants for the treatment of attention-deficit hyperactivity disorder in children ... Free with registration - Pediatric News - AccessMyLibrary.com

Modafinil helps some cocaine dependence.(Addiction Psychiatry) |...  -  Feb 1, 2008
Modafinil helps some cocaine dependence.(Addiction Psychiatry) ... find Clinical Psychiatry News articles. VIENNA -- Modafinil has now been found to be ... Pay-Per-View - Clinical Psychiatry News - HighBeam Research

Science of Sport: Modafinil - Banned drug works as ergogenic aid  -  Jun 30, 2005
Traces of the banned stimulant drug modafinil have been found in the urine of a number of world-class athletes, including US sprinter Kelli White. ... RunnersWeb

Integrity in Science Watch -- Week of 3/17/2006  -  Mar 17, 2006
Cephalon's Provigil (modafinil) is a non-amphetamine stimulant for adult sleep disorders. The company now wants to sell it in the booming ADHD drug ... GoozNew

The smart money's on brain-boosting pills for every ill  -  Jul 15, 2005
Modafinil, a drug developed to treat narcolepsy, has been shown to reduce impulsiveness and help people focus on problems. ... The Age

Brain reprogramming to 'cure' addicts.  -  Jul 10, 2005
These drugs include Modafinil, which is prescribed for narcolepsy. Another is Ritalin, which is currently prescribed by doctors to children and adults who ... Pay-Per-View - Independent - Factiva, from Dow Jones

Modafinil is Effective in Treating Excessive Sleepiness Associated …  -  Oct 16, 2007
A study published in the October 15 issue of the Journal of Clinical Sleep Medicine (JCSM) finds that modafinil is works well in the treatment of excessive ... MedIndia

Article: Pediatric modafinil shows results in ADHD.(Behavioral...  -  Jul 1, 2005
Pediatric modafinil shows results in ADHD.(Behavioral Pediatrics)(Brief Article) ... find Pediatric News articles. ATLANTA -- Results from new research ... Pay-Per-View - Pediatric News - HighBeam Research

Article: Modafinil for ADHD.(Drug overview) - Clinical Psychiatry...  -  Jan 1, 2006
Modafinil for ADHD.(Drug overview) ... find Clinical Psychiatry News articles. Modafinil film-coated tablets significantly improved clinical symptoms of ... Pay-Per-View - Clinical Psychiatry News - HighBeam Research

Article: Pediatric modafinil eased ADHD symptoms.(Mental Health)( …  -  Jul 15, 2005
Pediatric modafinil eased ADHD symptoms.(Mental Health)(attention deficit hypertensive disorder) ... find Family Practice News articles. Pay-Per-View - Family Practice News - HighBeam Research

Article: Antinarcolepsy drug may improve ADHD: modafinil could prove...  -  Jul 1, 2005
Antinarcolepsy drug may improve ADHD: modafinil could prove an alternative to stimulants for addressing symptoms, phase III studies show. Pay-Per-View - Clinical Psychiatry News - HighBeam Research

How to take Modafinil from Consumer Reports Health.  -  Jan 11, 2007
...tell your doctor and pharmacist if you are allergic to modafinil, armodafinil (Nuvigil), or any other medications. tell your doctor and pharmacist what ... consumerreports.org

… no withdrawal syndrome with modafinil.(Behavioral Pediatrics) -...  -  Aug 1, 2005
Trial finds no withdrawal syndrome with modafinil.(Behavioral Pediatrics) ... find Pediatric News articles. BOCA RATON, FLA. Pay-Per-View - Pediatric News - HighBeam Research

Smart drugs for straight As  -  May 14, 2007
Within an hour of taking a drug called Modafinil, though, ... Modafinil, though, is one of a new breed of “smart� drugs that offer targeted, more powerful ... Times Online

Article: FDA panel: modafinil not safe for children.(News) - Pediatric...  -  Apr 1, 2006
FDA panel: modafinil not safe for children.(News) ... find Pediatric News articles. GAITHERSBURG, MD. -- A Food and Drug Administration advisory committee ... Pay-Per-View - Pediatric News - HighBeam Research

THE PEP PILLS THAT LET YOU SLEEP JUST.. 2 HOURS  -  Feb 16, 2006
Scientists are hoping to build on the success of the drug Modafinil, a stimulant launched seven years ago and which allows people to wake up refreshed after ... Mirror.co.uk

Modafinil dose higher in narcolepsy than apnea.(Neuropsychiatric …  -  Jan 1, 2005
PHILADELPHIA -- The median dose of modafinil was 300 mg for patients with obstructive sleep apnea and 400 mg for patients with narcolepsy in long-term ... Free with registration - Clinical Psychiatry News - AccessMyLibrary.com

Modafinil for ADHD May Be Another Alternative to Stimulants  -  Aug 7, 2006
Previous research has supported the effectiveness of modafinil in treating children with ADHD. These investigators used a smaller and more easily swallowed ... Medscape

Modafinil Can Improve Physical Fatigue in Patients With Parkinson's …  -  Oct 9, 2007
By Maggie Schwarz. WASHINGTON, DC -- October 9, 2007 -- Modafinil can reduced physical fatigue commonly seen in patients with Parkinson's disease, ... DG News

No withdrawal syndrome seen with modafinil for ADHD.(Mental Health)  -  Oct 1, 2005
Boca Raton, Fla. -- Children and adolescents with attention-deficit hyperactivity disorder did not experience withdrawal or discontinuation syndrome after ... Free with registration - Family Practice News - AccessMyLibrary.com

FDA panel: modafinil is not safe for treating ADHD in teens.(Mental...  -  Apr 15, 2006
Gaithersburg, Md. -- A Food and Drug Administration advisory committee said modafinil is not safe for treating ADHD in children and adolescents by a 12-1 ... Pay-Per-View - Family Practice News - Factiva, from Dow Jones

Article: Modafinil reduces severe cancer fatigue.(Across Specialties)...  -  Aug 1, 2008
Modafinil reduces severe cancer fatigue.(Across Specialties) ... find Clinical Psychiatry News articles. CHICAGO -- The wakefulness-promoting drug modafinil ... Pay-Per-View - Clinical Psychiatry News - HighBeam Research

Modafinil (Provigil) Pediatric Formulation Shows Early, Sustained...  -  May 26, 2005
By Bruce Sylvester. ATLANTA, GA -- May 26, 2005 -- Pediatric formulation modafinil (Provigil) is effective quickly, has a sustained effect and is well ... DG News

FDA cites Stevens-Johnson in modafinil's ADHD rejection.(News)( …  -  Sep 1, 2006
Modafinil, first approved for narcolepsy almost a decade ago, ... In a group of 933 children and adolescents treated with modafinil in trials, there were 12 ... Pay-Per-View - Clinical Psychiatry News - Factiva, from Dow Jones

Small Modafinil Study Shows Promise for Treatment of Bipolar Disorder  -  Aug 2, 2007
ROCHESTER, MN -- August 2, 2007 -- A preliminary study of 85 patients with bipolar disorder shows that a drug used to treat patients with sleep disorders ... DG News

Modafinil for ADHD.(Drug overview)  -  Jan 1, 2006
Modafinil film-coated tablets significantly improved clinical symptoms of attention-deficit hyperactivity disorder in children and adolescents aged 6-17 ... Free with registration - Clinical Psychiatry News - AccessMyLibrary.com

Does Modafinil Treat Shift-work Sleep Disorder?: Synopsis  -  Apr 21, 2006
Shift-work sleep disorder affects approximately 5-10% of night-shift workers, and involves excessive sleepiness during night shifts and insomnia when trying ... Medscape

Modafinil investigated to reduce daytime sleepiness in PD patients.(Ne...  -  Feb 1, 2006
Researchers at Baylor College of Medicine have concluded that modafinil failed to show a significant reduction of daytime somnolence in elderly men with ... Free with registration - Brown University Geriatric Psychopharmac... - AccessMyLibrary.com

Mylan Receives Tentative Approval for Modafinil Tablets.  -  Feb 10, 2005
Mylan Laboratories Inc. today announced that the US Food and Drug Administration has granted tentative approval for Mylan Pharmaceuticals Inc.'s Abbreviated ... $4.95 - PR Newswire - ECNext

Article: Modafinil reduces severe cancer-related fatigue.(Clinical...  -  Jul 1, 2008
CHICAGO -- The wakefulness-promoting drug modafinil (Provigil) reduced self-reported severe fatigue, according to a study presented at the annual meeting of ... Pay-Per-View - Family Practice News - HighBeam Research

NIH studies modafinil for cocaine addiction.(Research Roundup)(United...  -  Jun 1, 2006
Although conclusive evidence is still pending in the form of a large-scale, National Institutes of Health funded research project, addiction specialists see ... Free with registration - Brown University Digest of Addiction... - AccessMyLibrary.com

… Fatigue Treated With Psychostimulant Modafinil: Presented at ASCO  -  May 23, 2005
Findings from a 1-month study undertaken to determine whether modafinil could ... The patients were asked to take modafinil, 200 mg/day before breakfast. ... DG News

Alfresa Pharma Files Manufacturing Approval for Modafinil for...  -  Apr 18, 2005
Tokyo, Apr 18, 2005 (JCN) - Alfresa Holdings (TSE: 2784) announced on April 15 that its wholly owned subsidiary Alfresa Pharma has filed an application for ... japancorp.net

Modafinil An Effective Treatment For The Ill-Effects Of Sleep...  -  Nov 5, 2006
The wake-promoting drug modafinil serves as an effective countermeasure to the adverse effects of overnight sleep deprivation on working memory, ... Medical News Today - Medical News Today (press release)

Cephalon shares fall after FDA rejects hyperactivity drug  -  Aug 11, 2006
Sparlon is a higher dose of modafinil, the active ingredient in Provigil. The FDA's decision to reject Sparlon sparked a concern that the agency might ... $2.95 - Deseret News - NewsBank

Modafinil Appears to Improve Fatigue, Mental Well-Being of Patients...  -  Jun 6, 2006
By Ed Susman. ATLANTA, GA -- June 6, 2006 -- Patients battling primary brain tumors appear to improve cognition and decrease depression and fatigue by ... DG News

Sleep no more  -  Apr 1, 2006
Meet modafinil, "the first wave of new lifestyle drugs that promise to do for sleep what ... "Modafinil has made it possible to have 48 hours of continuous ... Globe and Mail

COLUMN: Modafinil may be as bad as amphetamine relatives | Article …  -  Dec 14, 2006
COLUMN: Modafinil may be as bad as amphetamine relatives ... find University Wire articles. Ben Dedman University Wire 12-14-2006 (The Guilfordian) (U-WIRE) ... Pay-Per-View - University Wire - HighBeam Research

Brand Names/Synonyms:
Modafinil is also known by the following brand names and/or synonymsCEP 1538; CHEMBANK1788; CRL 40476; Dea No. 1680; MODAFINIL; Modafinil; Modafinil [Usan:Inn]; Modafinilo [Spanish]; Modafinilum [Latin]; Moderateafinil; Modiodal; Provigil

Drug Category:
Modafinil is categorized under the following by the FDA: Neuroprotective Agents; Central Nervous System Agents; Anorexigenic Agents; Stimulants; ATC:N06BA07

Dosage Forms:
TABLET

Absorption:
Rapid

Interactions:
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Chemical IUPAC Name:
2-benzhydrylsulfinylethanamide





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