Moxifloxacin

This page contains recent news articles, when available, and an overview of Moxifloxacin but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Moxifloxacin
(when available)

Pharmacology and use:
Moxifloxacin is a quinolone/fluoroquinolone antibiotic. Moxifloxacin is bactericidal and its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase, which allows the untwisting required to replicate one DNA double helix into two. Notably the drug has 100 times higher affinity for bacterial DNA gyrase than for mammalian. Moxifloxacin is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria. For the treatment of bacterial conjunctivitis caused by susceptible strains of the following organisms: Corynebacterium species* Acinetobacter lwoffii* Micrococcus luteus* Haemophilus influenzae Staphylococcus aureus Haemophilus parainfluenzae* Staphylococcus epidermidis Staphylococcus haemolyticus Staphylococcus hominis Chlamydia trachomatis Staphylococcus warneri* Streptococcus pneumoniae

Mechanism Of Action:
The bactericidal action of Moxifloxacin results from inhibition of the enzymes topoisomerase II (DNA gyrase) and topoisomerase IV, which are required for bacterial DNA replication, transcription, repair, and recombination.

News Articles on Moxifloxacin

New, Virulent Strain of MRSA Poses Renewed Antibiotic Resistance Concerns  -  ‎Dec 22, 2009‎
In the new research based on laboratory analysis, scientists identified linezolid and moxifloxacin as two antibiotics that would be effective against, ... Science Daily (press release)

Novartis to buy Aclon: Will The Gurus sell Their Shares of Novartis Now?  -  ‎Jan 4, 2010‎
Moxifloxacin is licensed to Alcon, Inc. by Bayer Healthcare AG. Alcon Inc. has a market cap of $49.14 billion; its shares were traded at around $164.35 with ... GuruFocus.com

Antibiotic Therapy in Elderly Patients with Acute Exacerbation of Chronic ...  -  ‎Dec 21, 2009‎
Eradication of H. influenzae in AECB: a pooled analysis of moxifloxacin Phase III trials compared with macrolide agents. Respir. Med. 100, 1781–1790 (2006). ... Medscape

Hypoglycemia Associated with the Use of Levofloxacin  -  ‎Jan 4, 2010‎
Avelox (moxifloxacin hydrochloride) package insert. West Haven, CT: Bayer Healthcare; 2005. Tequin (gatifloxacin) package insert. ... Medscape

Florida TB case most extensively drug-resistant yet in US  -  ‎Dec 29, 2009‎
...second-line therapies are available and include fluoroquinolones (levofloxacin, moxifloxacin, or gatifloxacin); amikacin, kanamycin , or capreomycin ... Pediatric SuperSite

Rib-X Pharmaceuticals Enters into Collaborative Agreement on Delafloxacin with ...  -  ‎Dec 15, 2009‎
...delafloxacin has been shown to be at least 32-fold more potent than levofloxacin, ciprofloxacin, gatifloxacin and moxifloxacin. ... PR Newswire (press release)

Generic Levaquin Is in the Pipeline  -  ‎Dec 14, 2009‎
...finds that the patent expiries of three blockbuster antibiotics—levofloxacin, moxifloxacin and piperacillin/tazobactam—will be the primary factors ... Lawyers and Settlements

Risk of Endophthalmitis After Intravitreal Drug Injection When Topical ...  -  ‎Dec 14, 2009‎
Penetration pharmacokinetics of topically administered 0.5% moxifloxacin ophthalmic solution in human aqueous and vitreous. Arch Ophthalmol. ... Archives of Ophthalmology

'ìž?ì?´ë³µìŠ¤Â·ì•„ë²¨ë¡?스' 지역사회 MRSA 효과  -  ‎Dec 27, 2009‎
...í•­ìƒ?ì œ 'ìž?ì?´ë³µìФ'(Zyvox, linezolid)와 '아벨ë¡?스'(Avelox, moxifloxacin)ê°€ 지역사회 ê°?ì—¼ 메티실린 내성 황색í?¬ë?„ìƒ?구균(MRSA)ì—? 가장 효과ì ?ì?´ê³  저항ì?„ ë?œ ... 디지틀보사

Thành công trong Ä‘iá»?u chế vaccin má»›i phòng lao  -  ‎Dec 23, 2009‎
BS Ann Wajja, Trưởng nhóm nghiên cứu tại Uganda cho biết: Ba trong tám loại vaccin Ä‘ang được thá»­ nghiệm lâm sàng, trong đó có moxifloxacin, có kết quả tốt ... XãLuận.com tin tức việt nam 24h cập nhật

Generic Name: Moxifloxacin hydrochloride  -  ‎Nov 11, 2009‎
Avelox is highly active against many different bacteria, including those that are most likely to contribute to acute bacterial sinusitis, ... Pattaya Daily News

Bayer to up R&D spend as Higgins looks to the future  -  ‎Nov 12, 2009‎
...therapy using the active ingredient moxifloxacin manufactured by Bayer which could cut the existing treatment period of six months by a third. ... Pharma Times

Rhabdomyolysis Associated With 2009 Influenza A(H1N1)  -  ‎Nov 3, 2009‎
Two days before presentation, she had been prescribed moxifloxacin and hydrocodone/acetaminophen for presumed pneumonia without any significant improvement. ... Journal of American Medical Association (subscription)

Bayer earnings fall again but pharma sales are healthy  -  ‎Oct 27, 2009‎
As for Bayer's antibiotics, Cipro/Ciprobay (ciprofloxacin) brought in 83 million euros, down 1.2%, while Avelox (moxifloxacin) fell 8.9% to 92 million euros ... Pharma Times

Novartis drug Tasigna(R) meets primary endpoint in pivotal trial against ...  -  ‎Oct 19, 2009‎
...but not limited to chloroquine, halofantrine, clarithromycin, haloperidol, methadone, moxifloxacin, bepridil, and pimozide) should be avoided. ... Reuters

Later generation fluoroquinolones may improve outcomes for patients with XDR-TB  -  ‎Oct 31, 2009‎
Later generation fluoroquinolones were defined as levoflxacin, moxifloxacin and sparfloxacin. An association between those medications and favorable ... Pediatric SuperSite

John Hussman Buys Ebay Inc., Dollar Tree, Inc., John Wiley & Sons Inc., Sells ...  -  ‎Nov 2, 2009‎
Moxifloxacin is licensed to Alcon Inc. by Bayer Healthcare AG. Alcon Inc. has a market cap of $42.52 billion; its shares were traded at around $142.29 with ... GuruFocus.com

ë°”ì?´ì—˜, 결핵치료 2개월 단축시킬 약 개발 추진  -  ‎Nov 13, 2009‎
...“결핵약 개발ì?„ 위한 글로벌 제휴â€? 기구와 협력해 ë°”ì?´ì—˜ì?˜ moxifloxacinì?˜ 병용 치료ì—? 대한 ìž„ìƒ? 연구를 실시하고 있으며 ì?´ 약물 투여로 결핵 치료기간ì?„ 현재ì?˜ 6 ... 메디포뉴스

Bayer, tuberculosis research group launch clinical trial to test...  -  Oct 18, 2005
If the trials are successful, the partnership wants to register moxifloxacin for a TB indication. They also want to make it affordable and accessible in ... Forbes

EU agency recommends restricting moxifloxacin use  -  Jul 25, 2008
FRANKFURT, July 24 (Reuters) - The European Medicines Agency has recommended limiting the use of oral moxifloxacin-containing medicines after finalizing a ... Reuters India

Studies: TB can be treated in few months  -  Sep 18, 2007
Adding the antibiotic moxifloxacin to the usual TB drugs shortened the time ... All were given three standard anti-TB drugs plus either moxifloxacin or an ... USA Today

Studies: TB can be treated in few months  -  Sep 19, 2007
Adding the antibiotic moxifloxacin to the usual TB drugs shortened the time ... All were given three standard anti-TB drugs plus either moxifloxacin or an ... 新�网

Gates Foundation awards $104 million to fight TB in Third World  -  May 24, 2006
The New York-based TB Alliance is developing 11 experimental tuberculosis treatments, with the drug moxifloxacin the most advanced candidate. ... USA Today

New antibiotic drug combo to speed up treatment of tuberculosis  -  Sep 19, 2007
Adding moxifloxacin to a standard combination of other antibiotics increased by 17 ... Moxifloxacin, approved for use in the United States since 1999 as a ... Hindu

Vitreous and aqueous penetration of orally administered moxifloxacin...  -  Sep 30, 2005
To investigate the intraocular penetration of moxifloxacin into the aqueous and ... The meanSD sampling times after oral administration of the moxifloxacin ... Nature.com

Acorda MS drug passes heart safety test  -  Jan 28, 2008
Moxifloxacin was used as a control drug because it is known to increase QT interval, Acorda said. Friedman, Billings, Ramsey analyst David Amsellem said in ... Reuters

How effective is moxifloxacin for the first-line treatment of...  -  Jul 15, 2005
Nista EC et al. (2005) Moxifloxacin-based strategies for first-line treatment of Helicobacter pylori infection. Aliment Pharmacol Ther 21: 1241–1247 PubMed ... Nature.com

ICAAC: Moxifloxacin could cut TB treatment time to four months  -  Sep 18, 2007
Using the antibiotic moxifloxacin instead of ethambutol in TB treatment increases the cure rate and could cut the length of treatment from six to four ... Aidsmap

Gates Foundation gives group $104 million for TB drug research  -  May 25, 2006
The New York-based TB Alliance is developing 11 experimental tuberculosis treatments, with the drug moxifloxacin the most advanced candidate. ... Seattle Times

German shares higher midday on Wall Street gains as pharmaceuticals …  -  Oct 18, 2005
...for TB Drug Development to study the potential of the existing antibiotic moxifloxacin to shorten the standard 6-month treatment of tuberculosis. ... Forbes

Researchers find improved treatment for pneumonia in elderly  -  Jan 24, 2006
The antibiotic moxifloxacin HCI has proved more effective in battling community-acquired pneumonia in patients 65 and older than levofloxacin, ... Bizjournals.com

Moxifloxacin Shows Benefits for Patients With Odontogenic Inflammatory...  -  Apr 28, 2008
By Chris Berrie. BARCELONA, Spain -- April 28, 2008 -- Moxifloxacin is significantly more effective at reducing pain than clindamycin, is well tolerated, ... DG News

If Successful, Moxifloxacin Could Be First New Treatment For TB In...  -  Oct 19, 2005
A Johns Hopkins infectious disease expert will lead two international studies of the effectiveness of the antibiotic moxifloxacin as a new treatment for ... Medical News Today - Medical News Today (press release)

Moxifloxacin Shows Lower-Than-Expected Cure Rates in Tuberculosis in ...  -  Sep 20, 2007
By John Gever. CHICAGO, IL -- September 20, 2007 -- Moxifloxacin performed as well as isoniazid in treating pulmonary tuberculosis (TB) in a multinational ... DG News

Efficacy of Once-Daily Moxifloxacin in Treating Complicated Intra- …  -  Oct 13, 2006
SAN FRANCISCO, CA -- October 13, 2006 -- The efficacy of monotherapy with the once-daily, broad-spectrum antibiotic Avelox® (moxifloxacin HCl) in the ... DG News

Once-Daily Oral Moxifloxacin Shows Equivalence to Ciprofloxacin Plus ...  -  Apr 24, 2008
By Chris Berrie. BARCELONA, Spain -- April 24, 2008 -- Oral moxifloxacin at a single daily dose shows equivalence to the multiple dosing of ciprofloxacin ... DG News

New TB drugs enter advanced stages of clinical trial  -  Nov 11, 2007
The two antibiotics Moxifloxacin and PA-824 are being developed by the TB Alliance, ... Moxifloxacin, being developed in partnership with Bayer, ... Hindu

Vegamox(TM) (Moxifloxacin Hydrochloride Ophthalmic Solution) …  -  Jul 27, 2006
FORT WORTH, TX -- July 27, 2006 -- Alcon, Inc. announced that the Ministry of Health, Labor and Welfare in Japan has approved its Vegamoxâ„¢ (moxifloxacin ... DG News

… Agency Recommends Restricting The Use Of Oral Moxifloxacin- …  -  Jul 28, 2008
Finalising a review of the safety of moxifloxacin-containing medicines for ... Oral formulations of medicines containing moxifloxacin are authorised at the ... Medical News Today - Medical News Today (press release)

Aqueous penetration of moxifloxacin found to be significant comparison...  -  Apr 1, 2005
Dallas -- Moxifloxacin 0.5% (Vigamox, Alcon Laboratories) outperformed gatifloxacin 0.3% (Zymar, Allergan) in a comparative study of the penetration of ... Free with registration - Ophthalmology Times - AccessMyLibrary.com

Africa: Two New TB Drugs May Reduce Treatment Time  -  Nov 8, 2007
A large scale Phase III clinical trial in TB patients is beginning with the antibiotic moxifloxacin, already approved for other respiratory indications. ... AllAfrica.com

Moxifloxacin (Ophthalmic).  -  Feb 1, 2006
Moxifloxacin(mox-ee-FLOX-a-sin) belongs to the family of medicines called antibiotics. Moxifloxacin ophthalmic solution (eye drops) is used to treat ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Moxifloxacin Alone Equals Combo Regimen in Pneumonia  -  May 16, 2008
By John Gever, Staff Writer, MedPage Today. BARCELONA, May 16 -- Moxifloxacin (Avelox) alone was as effective as a standard combination of two intravenous ... MedPage Today

Dispatch Online - Your premier Eastern Cape news site  -  Oct 19, 2005
The partnership aims to register moxifloxacin for a TB indication and has committed to making it affordable and accessible in developing countries. ... Dispatch Online

South Africa: Volunteers Sought for New TB Antibiotic  -  Nov 12, 2007
Moxifloxacin is one of the most advanced potential new TB drugs in development, ... The moxifloxacin trial, dubbed REMoxTB, has been developed by the Global ... AllAfrica.com

Alcon, Bayer file patent infringement lawsuit against generic drug...  -  Apr 5, 2006
Alcon licenses the generic version of the drug, moxifloxacin, from Bayer HealthCare AG, a German pharmaceuticals company. North Wales, Pa. ... Bizjournals.com

… Welcomes The Proposed EMEA Labeling Changes For Moxifloxacin  -  Jul 28, 2008
Bayer is pleased to announce that today the European Medicines Agency's (EMEA) Committee for Medicinal Products for Human Use (CHMP) proposed a labeling ... Medical News Today - Medical News Today (press release)

ICAAC: Moxifloxacin as effective as ethambutol in TB treatment  -  Dec 19, 2005
A new anti-TB drug called moxifloxacin proved just as effective as ethambutol as part of a four-drug induction regimen for TB treatment, the Tuberculosis ... Aidsmap

Moxifloxacin Concentrations Higher Than Gatifloxacin in Eye Surgery: ...  -  May 4, 2006
By Michael Casasnovas. FT. LAUDERDALE, FL -- May 4, 2006 -- Higher antimicrobial activity and concentration of moxifloxacin (Vigamox) when compared to ... DG News

Moxifloxacin provides prophylaxis against bacterial growth: lash...  -  Apr 1, 2007
Beaumont, TX -- Moxifloxacin (Vigamox, Alcon Laboratories) appears to be superior to gatifloxacin (Zymar, Allergan) in preventing the growth of ... Free with registration - Ophthalmology Times - AccessMyLibrary.com

Pupil Size Differences Noted With Moxifloxacin and Gatifloxacin...  -  May 5, 2008
By Ed Susman. FORT LAUDERDALE, Fla -- May 5, 2008 -- Patients who are treated with the antibiotic moxifloxacin 0.5% before having cataract surgery appear to ... DG News

Treatment of ankylosing spondylitis with moxifloxacin.(Clinical...  -  Apr 1, 2007
Abstract: Ankylosing spondylitis (AS) is a human leukocyte antigen (HLA)-B27-associated chronic inflammatory disease of unknown etiology. ... $4.95 - Southern Medical Journal - ECNext

Moxifloxacin QD similar to piperacillin-tazobactam and amoxicillin- …  -  Sep 1, 2006
Intravenous (IV) moxifloxacin followed by oral (PO) moxifloxacin, both dosed once-daily, is at least as effective in the treatment of complicated ... $4.95 - Formulary - ECNext

Moxifloxacin has higher aqueous concentrations when given hours …  -  Aug 27, 2008
Administering topical moxifloxacin 2 hours before cataract surgery can achieve significantly higher aqueous concentrations than initiating dosing 1 day ... OSN SuperSite

… Approves New Indication for AVELOX(R) (moxifloxacin HCl) for...  -  Nov 30, 2005
FDA Approves New Indication for AVELOX(R) (moxifloxacin HCl) for Treatment of Complicated Intra-Abdominal Infections (cIAI). from PR Newswire. Pay-Per-View - PR Newswire - HighBeam Research

Orally administrated moxifloxacin achieves therapeutic levels  -  Apr 13, 2006
Orally administered moxifloxacin reaches therapeutic levels in the noninflamed eye while maintaining good tolerability, researchers found. ... OSN SuperSite

FDA Approves New Indication for Avelox (moxifloxacin HCl) for...  -  Nov 30, 2005
KENILWORTH, NJ -- November 30, 2005 -- Schering-Plough Corporation today announced that the US Food and Drug Administration (FDA) has approved the ... DG News

Moxifloxacin Favourable for Patients with Chronic Bronchitis:...  -  May 25, 2007
By Suzette Smiley-Jewell. SAN FRANCISCO, CA -- May 25, 2007 -- Moxifloxacin antibiotic is safe and effective for treating frequent acute exacerbation of ... DG News

Comparison of Manual and Automated Measurements of the QT Interval …  -  Dec 14, 2008
The time courses of post-moxifloxacin changes over the measurement period were ... With only one exception (study 5, moxifloxacin), the variability ... Nature.com

Antibacterial Agents; Moxifloxacin is effective treatment for...  -  Oct 3, 2006
2006 OCT 3 - (NewsRx.com) -- Moxifloxacin was as effective as piperacillin-tazobactam and amoxicillin-clavulanate for the treatment of complicated ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

… New Quinolone Antibacterial "Avelox(R) Tablet 400mg" (Moxifloxacin...  -  Dec 10, 2005
Product name: Avelox(R) Tablet 400mg Generic name: Moxifloxacin hydrochloride Acquisition of import approval: October 11, 2005 NHI drug price listing: ... Free with registration - JCN Newswires - AccessMyLibrary.com

Emerging Drugs for Active Tuberculosis: Emerging Drugs for TB: …  -  Mar 17, 2008
The furthest advanced of these seven are two drugs belonging to the family of C8-methoxy fluoroquinolones: gatifloxacin and moxifloxacin. ... Medscape

Older Antibiotic Gains New Respect as Potent Treatment for Tuberculosi...  -  Dec 17, 2007
Chaisson and his group showed that moxifloxacin (Avelox), ... After 10 weeks of drug therapy, mice taking rifapentine and moxifloxacin tested negative for ... Free with registration - Ascribe Higher Education News Service - AccessMyLibrary.com

Rabbit study shows therapeutic levels of moxifloxacin at 12 hours  -  Jan 10, 2006
Therapeutic levels of moxifloxacin were present in rabbit eyes at 12 hours after intravitreal injection, according to a recent study. ... OSN SuperSite

… Announces FDA Approval of Avelox MOXIFLOXACIN HCL for Treatment …  -  Jul 6, 2005
Schering-Plough Corporation (NYSE: SGP) today announced that the US Food and Drug Administration (FDA) has approved the once-daily antibiotic AVELOX® ... DentalPlans.com

Antibacterial Agents; Moxifloxacin pharmacokinetics and peritoneal …  -  Oct 17, 2006
The objective of recent research from Germany was "to investigate the penetration of moxifloxacin into peritoneal exudate in patients with complicated ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

High dose of old antibiotic offers potent TB treatment  -  Dec 18, 2007
It was demonstrated that moxifloxacin (Avelox), another antibiotic, ... After 10 weeks of drug therapy, mice taking rifapentine and moxifloxacin tested ... thecheers.org

FDA Approvals: Rozerem, Synera, Avelox IV  -  Jul 28, 2005
On June 13, the FDA approved a new indication for moxifloxacin HCl ... Success rates varied similarly between the moxifloxacin and comparator groups with ... Medscape

Avelox® Monotherapy Shows Strong Performance In Treating …  -  May 19, 2008
..."The results of MOTIV reinforce that moxifloxacin is an effective and well ... 5) Moxifloxacin, a member of the fluoroquinolone class of antibiotics ... Medical News Today - Medical News Today (press release)

Article: Moxifloxacin effective, safe for aspiration-related lung...  -  Dec 15, 2005
MONTREAL -- The potent respiratory fluoroquinolone moxifloxacin is as safe and effective as combination ampicillin/sulbactam therapy for the treatment of ... Pay-Per-View - Internal Medicine News - HighBeam Research

… of ankylosing spondylitis with moxifloxacin.(Clinical report) |...  -  Apr 1, 2007
Treatment of ankylosing spondylitis with moxifloxacin.(Clinical report) ... find Southern Medical Journal articles. Abstract: Ankylosing spondylitis (AS) is ... Pay-Per-View - Southern Medical Journal - HighBeam Research

Moxifloxacin treats aspiration pneumonia.(Infectious Diseases)  -  Dec 1, 2005
MONTREAL -- The potent respiratory fluoroquinolone moxifloxacin is as safe and effective as combination ampicillin/sulbactam therapy for the treatment of ... Pay-Per-View - Family Practice News - Factiva, from Dow Jones

Global Warming & Disease, Crib Bumpers, Moxifloxacin for TB, FluMist  -  Sep 20, 2007
...(September 20, 2007 - Insidermedicine) From Chicago - Thousands of researchers are gathering at the meeting of the American Society for Microbiology to ... Insidermedicine

SP announces positive Avelox study data  -  Apr 10, 2006
The results are derived from the moxifloxacin treatment intravenous (MOTIV) study, which directly compared once-daily 400mg Avelox treatment with a combined ... Pay-Per-View - Pharma Marketletter - Factiva, from Dow Jones

FDA approves AVELOX (moxifloxacin HCl) for treatment of complicated …  -  Nov 28, 2005
Schering-Plough Corporation (NYSE: SGP) today announced that the US Food and Drug Administration (FDA) has approved the once-daily, broad-spectrum ... PsychCentral.com

moxifloxacin Shionogi marketed, Japan (bacterial infection).  -  Dec 19, 2005
Shionogi announced on 9 December 2005 that it has launched the fluoroquinolone antibiotic moxifloxacin (AVELOX) in Japan as a treatment for bacterial ... Pay-Per-View - R & D Focus Drug News - Factiva, from Dow Jones

Researchers Identify Antibiotics Most Likely to Cause Clostridium...  -  Sep 28, 2006
Moxifloxacin was associated with an OR of 1.67 (P = .03). The other antibiotics studied had weaker associations, Dr. Baxter said. ... DG News

Article: Moxifloxacin treats aspiration pneumonia.(Infectious...  -  Dec 1, 2005
Moxifloxacin treats aspiration pneumonia.(Infectious Diseases) ... find Family Practice News articles. MONTREAL -- The potent respiratory fluoroquinolone ... Pay-Per-View - Family Practice News - HighBeam Research

TB treatment and diagnostics pipeline: once empty, suddenly offers...  -  Dec 2, 2005
Bayer will donate moxifloxacin for each trial site and will cover the costs of ... Preclinical studies have shown that moxifloxacin has potent anti-TB ... Aidsmap

Intracameral fluoroquinolone safe for endophtalmitis prevention  -  Mar 1, 2008
Off-the-shelf ophthalmic moxifloxacin solution is safe for intracameral use during ... One eye showed traces of corneal edema in the moxifloxacin group. ... OSN SuperSite

… dosage forms of itraconazole, moxifloxacin recommended for...  -  Jun 5, 2006
Bayer Yakuhin is already supplying Avelox Tablet, an oral version of moxifloxacin, on behalf of Shionogi. Orphan drug designation has been granted to Denka ... Pay-Per-View - Pharma Japan - Factiva, from Dow Jones

… Announces FDA Approval of AVELOX(R) (moxifloxacin HCl) for Treatment...  -  Jun 30, 2005
Schering-Plough Announces FDA Approval of AVELOX(R) (moxifloxacin HCl) for Treatment of Complicated Skin and Skin Structure Infections. from PR Newswire. Pay-Per-View - PR Newswire - HighBeam Research

TB Alliance Appoints Mark Kessel to Board of Directors.  -  Nov 2, 2005
For more information on TB drug development, moxifloxacin and the TB Alliance, please visit http://www.tballiance.org/. Free with registration - PR Newswire - AccessMyLibrary.com

Alcon's VEGAMOX(TM) Ophthalmic Solution Approved in Japan for Eye …  -  Jul 26, 2006
Moxifloxacin hydrochloride ophthalmic solution 0.5 % is licensed to Alcon, Inc. by Bayer HealthCare, AG. Caution Concerning Forward-Looking Statements. ... Genetic Engineering News - Genetic Engineering News (press release)

Schering-Plough's Avelox shows efficacy in trial  -  Oct 2, 2006
The study compared the efficacy and safety of moxifloxacin to that of combination therapy ... In the study, moxifloxacin monotherapy was as effective as the ... Pay-Per-View - Datamonitor News and Comment - Factiva, from Dow Jones

New Antibiotic Drug Combo to Speed Up Treatment of Tuberculosis  -  Sep 14, 2007
Adding moxifloxacin to a standard combination of other antibiotics increased by 17 ... Moxifloxacin, approved for use in the United States since 1999 as a ... newswise.com

Real-life Treatment of Acute Exacerbation of Chronic Bronchitis: …  -  Apr 6, 2006
Patients were treated with either moxifloxacin tablets (400 mg OD) or the ... Total recovery rates were also significantly better with moxifloxacin than the ... DG News

Efficacy of once-daily Avelox for complicated abdominal infections …  -  Sep 29, 2006
Patients received either intravenous (IV) followed by oral moxifloxacin (400 mg, ... In the study, moxifloxacin monotherapy was as effective as the ... eurekalert.org

TB Alliance Advances Two Drugs in Clinical Trials on Path to Faster, ...  -  Aug 11, 2007
A large scale, pivotal Phase III clinical trial in TB patients is beginning with the antibiotic moxifloxacin, already approved for other respiratory ... Ad-Hoc-News - Ad-Hoc-News (Pressemitteilung)

Ancient remedy: Drug-resistant TB is a global problem  -  Oct 24, 2005
In an unprecedented move, drug multinational Bayer announced last Monday that it will allow its new antibiotic moxifloxacin to be tested against ... Calcutta Telegraph

Antibiotic Drug Combo to Speed Up Treatment of Tuberculosis  -  Nov 30, 2007
Adding moxifloxacin to a standard combination of other antibiotics increased by 17 ... Moxifloxacin, approved for use in the United States since 1999 as a ... Virtual Medical Centre - The Virtual Medical Centre

DRL to appeal for Avelox against Bayer  -  Nov 3, 2007
...two patents on Avelox (Moxifloxacin hydrochloride) of Bayer AG with a generic version, the company has decided to appeal to the Federal Circuit. ... Financial Express

Antibiotic speeds corneal wound healing after PRK.(Prophylactic …  -  Jul 15, 2005
Then the study medications gatifloxacin 0.3% and moxifloxacin 0.5% were ... One eye treated with topical moxifloxacin developed corneal haze and had a BCVA ... Free with registration - Ophthalmology Times - AccessMyLibrary.com

Antibiotic-soaked IOLs show efficacy against bacteria  -  May 1, 2008
The concentration of gatifloxacin and moxifloxacin were 2.3 mcg/mL and 3 ... At 12 hours, gatifloxacin concentration was 4 mcg/mL and moxifloxacin was 2.6 ... OSN SuperSite

Quinolone safety and efficacy.(LETTERS)(Letter to the Editor)  -  Jun 1, 2005
As with gatifloxacin and moxifloxacin, few peer-reviewed, published data support the ... Moxifloxacin has greater activity against Streptococcus pneumoniae, ... $4.95 - Emerging Infectious Diseases - ECNext

Hopkins Scientist to Direct International Studies of Antibiotic as...  -  Oct 17, 2005
Moxifloxacin is currently approved in more than 100 countries, ... His research will assess the ability of moxifloxacin to shorten the treatment period ... Free with registration - Ascribe Higher Education News Service - AccessMyLibrary.com

Switching Fluoroquinolones in Patients With Neutropenia May Increase ...  -  Dec 19, 2005
They conducted a prospective observational study in which moxifloxacin was used as ... The investigators compared 283 neutropenic episodes with moxifloxacin ... DG News

Proper use of antibiotics essential for good outcomes.(Refractive...  -  Mar 15, 2005
Moxifloxacin has a bicyclic side-chain at C-7 that inhibits the cell's ... A study of moxifloxacin and gatifloxacin in patients undergoing LASIK found no ... Free with registration - Ophthalmology Times - AccessMyLibrary.com

Literature-based evaluation of four 'hard endpoint' models for...  -  Jul 7, 2008
However, TdP has not been documented with moxifloxacin use (Frothingham, 2001). ... Moxifloxacin, a clinically widely prescribed antibiotic, ... Nature.com

Quinolones found comparable in elderly patients with CAP.(Infectious ...  -  Feb 15, 2005
Investigators observed trends that favored moxifloxacin (Avelox) over ... Of the total group, 141 patients were randomized to moxifloxacin 400 mg/day, ... Free with registration - Internal Medicine News - AccessMyLibrary.com

Lower Respiratory Tract Infections - Experts promote earlier use of...  -  Sep 21, 2005
The MOSAIC study compared moxifloxacin to standard (non-fluoroquinolone) antibiotics ... "Moxifloxacin achieved a cure rate of more than 90 percent in all ... Medical News Today - Medical News Today (press release)

Challenges in tuberculosis drug research and development  -  Mar 1, 2007
Moxifloxacin, being evaluated under the umbrella of a Bayer Healthcare–Global ... A post hoc analysis further demonstrated that moxifloxacin substituted for ... Nature.com

Antibiotics; Studies from the United States and Spain describe new …  -  Oct 23, 2006
Study 1: Moxifloxacin was as effective as piperacillin-tazobactam and ... Bacterial eradication rates were 78% (117 of 150) with moxifloxacin vs 77% (126 of ... Pay-Per-View - Clinical Trials Week - Factiva, from Dow Jones

University of Chicago, US Researchers' data from University of...  -  Dec 12, 2006
Study 3: Moxifloxacin delivery via collagen shield shows promise for ocular ... "Moxifloxacin 0.5% was administered before vitrectomy surgery in 10 patients ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

Pharmacologic agents associated with QT interval prolongation.  -  Jun 1, 2005
...(19-24) In critically ill patients, moxifloxacin was associated with a ... (21) Moxifloxacin was associated with the greatest mean increase in QTc values in ... Pay-Per-View - Journal of Family Practice - Factiva, from Dow Jones

Pharmacologic agents associated with QT interval prolongation.  -  Jun 1, 2005
...(19-24) In critically ill patients, moxifloxacin was associated with a ... (21) Moxifloxacin was associated with the greatest mean increase in QTc values in ... $4.95 - Journal of Family Practice - ECNext

Tuberculosis, a neglected opportunity?  -  Nov 2, 2006
Moxifloxacin is a synthetic fluoroquinolone antibiotic manufactured by Bayer and ... A phase 2-3 trial with moxifloxacin is underway, and will compare a ... Nature.com

Reply to Kampougeris et al  -  Jul 6, 2007
Kampougeris et al state that we decided to test moxifloxacin because of its low ... We had in fact mentioned that the MIC 90 of moxifloxacin was lower than ... Nature.com

Bayer: Rettung für Weichteile  -  Jul 18, 2005
Das Medikament kann nach Angaben von Bayer als Infusionslösung mit dem Wirkstoff Moxifloxacin nun in allen 17 EU-Staaten vermarktet werden. ... ARD

Reducing the risk of endophthalmitis using prophylaxis  -  May 10, 2008
Studies show that moxifloxacin achieves higher tissue concentration in the ... 10 Data from a study in which both moxifloxacin and gatifloxacin were dosed ... OSN SuperSite

TB Alliance and Bayer launch historic global drug trials for tuberculo...  -  Oct 14, 2005
Bayer will donate moxifloxacin for each trial site and will cover the costs of ... The trials will evaluate whether the substitution of moxifloxacin for one ... PsychCentral.com

FDA Approvals: Avelox, Avandaryl, Trileptal  -  Dec 1, 2005
On November 22, the FDA approved a new indication for moxifloxacin HCl (Avelox ... In both studies, moxifloxacin was effective at eradicating the key ... Medscape

Relative value of different fluoroquinolones.  -  Nov 1, 2007
It has already been shown (1) that moxifloxacin alone is more potent than both ... Wagner et al showed that the concentration of moxifloxacin in conjunctiva ... $4.95 - Ear, Nose and Throat Journal - ECNext

Quinolones compare in elderly with pneumonia.(Infectious Diseases)  -  Jan 1, 2005
Investigators observed trends that favored moxifloxacin (Avelox) over ... Of the total group, 141 patients were randomized to moxifloxacin 400 mg/day, ... Pay-Per-View - Family Practice News - Factiva, from Dow Jones

Azithromycin failure in Mycoplasma genitalium urethritis.(DISPATCHES)  -  Jul 1, 2006
Moxifloxacin administration resulted in rapid symptom resolution and eradication of infection in ... Persistent infection was eradicated with moxifloxacin. ... Free with registration - Emerging Infectious Diseases - AccessMyLibrary.com

Loislaw Federal District Court Opinions - BAYER AG v. DR. REDDY'S …  -  Oct 25, 2007
The active ingredient in AVELOX® is moxifloxacin hydrochloride, ... fn2] (D.I. 1) Reddy concedes that its generic moxifloxacin product infringes both ... Pay-Per-View - Loislaw Federal District Court Opinions - Loislaw

Hopkins Scientist to Direct International Studies of Antibiotic as...  -  Oct 17, 2005
Moxifloxacin is currently approved in more than 100 countries, ... His research will assess the ability of moxifloxacin to shorten the treatment period ... Pay-Per-View - Ascribe Higher Education News Service - HighBeam Research

New drug combination 'speeds TB recovery'  -  Sep 28, 2007
Adding the antibiotic moxifloxacin to the standard combination of drugs currently used ... Researchers compared the efficiency of using the moxifloxacin and ... TropIKA

Brand Names/Synonyms:
Moxifloxacin is also known by the following brand names and/or synonymsAvelox; Avelox I.V.; CHEMBANK1636; Moxifloxacin; Moxifloxacin Hcl; Moxifloxacin Hydrochloride; Vigamox

Drug Category:
Moxifloxacin is categorized under the following by the FDA: Anti-bacterial Agents; Quinolones; ATC:J01MA14

Dosage Forms:
SOLUTION; TABLET

Absorption:
Not Available

Interactions:
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Chemical IUPAC Name:
1-cyclopropyl-7-(5,8-diazabicyclo[4.3.0]non-8-yl)-6-fluoro-8-methoxy-4-oxo-1H-quinoline-3-carboxylicacid





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