|
 |
MuromonabThis page contains recent news articles, when available, and an overview of Muromonab but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.Overview: Muromonab (when available) Used in organ transplant prophylaxis, Muromonab or OKT-3 binds specifically to the CD-3 complex, which is involved in antigen recognition and cell stimulation, on the surface of T lymphocytes. Immediately after administration CD- 3-positive T lymphocytes are abruptly removed from circulation. It has been effective in reversing corticosteroid-resistant acute rejection in renal, liver, and cardiac transplant recipients. For treatment of organ transplant recipients, prevention of organ rejection Mechanism Of Action: Muromonab binds to the T-cell surface glycoprotein CD3 epsilon chain. It appears to kill CD-3 positive cells by inducing Fc mediated apoptosis, antibody mediated cytotoxicity and complement-dependent cytotoxicity. News Articles on Muromonab Muromonab-CD3 (Orthoclone OKT3 ® ), methylprednisolone and … - Jul 24, 2006 Correspondence: Dr PL McCarthy Jr, Department of Medicine, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA. ... Nature.com Muromonab-CD3 (Systemic). - Jul 28, 2005 Muromonab-CD3 (myoo-roe-MOE-nab cee-dee-three) is a monoclonal antibody. It is used to reduce the body's natural immunity in patients who receive organ (for ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com Treatment of steroid-resistant acute GVHD with OKT3 and high-dose … - May 10, 2007 Twenty-four of 40 patients (60%) who received OKT3 muromonab experienced signs ... OKT3 muromonab as second-line and subsequent treatment in recipients of ... Nature.com Aseptic meningitis after intrathecal baclofen injection - Sep 20, 2005 The nonsteroidal antiinflammatory drugs, 27 antimicrobials agents 28 and muromonab CD-3 29 are the most frequently implicated in hypersensitivity reactions. ... Nature.com Favorable outcomes of kidneys from non-heart-beating donors whose … - Aug 17, 2006 From July 1996, immunosuppression comprised triple therapy, with the addition of muromonab-CD3 or antithymocyte globulin for patients with panel-reactive ... Nature.com Cancers Increase Following Liver Transplantation - Oct 3, 2008 Acute rejection episodes were treated with steroids or muromonab-CD3 (Orthoclone OKT3) monoclonal antibodies. There were 39 incident cancers in 36 patients ... MedPage Today The Dawn of Biotech - Dec 22, 2008 ...(creating "abzymes") to create pharmaceuticals. Orthoclone OKT3® (Muromonab-CD3) approved for reversal of acute kidney transplant rejection. A regiment. 科学时报 Cyclophosphamide (Systemic). - Feb 1, 2006 Leukeran) or Corticosteroids (cortisone-like medicine) or Cyclosporine (eg, Sandimmune) or Mercaptopurine (eg, Purinethol) or Muromonab-CD3 (monoclonal ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com Bacillus Calmette-Guerin (BCG) Live--for Cancer (Mucosal-Local). - Jul 28, 2005 Intron A, Roferon-A) or Mercaptopurine (eg, Purinethol) or Methotrexate (eg, Mexate) or Muromonab-CD3 (eg, Orthoclone OKT3) or Plicamycin (eg, ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com Protein therapeutics and the regulation of quality: a brief history... - Oct 1, 2007 Also in 1986, muromonab-CD3, the first marketed monoclonal antibody, was approved for the treatment of allograft rejection. This murine monoclonal antibody ... $9.94 - Biopharm International - Alacra Store Chlorambucil (Systemic). - Oct 27, 2005 Sandimmune) or Cytarabine (eg, Cytosar-U) or Mercaptopurine (eg, Purinethol) or Muromonab-CD3 (monoclonal antibody) (eg, Orthoclone OKT3) or Tacrolimus ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com Cytarabine (Systemic).(Drug overview) - May 1, 2006 Leukeran) or Corticosteroids (cortisone-like medicine) or Cyclosporine (eg, Sandimmune) or Mercaptopurine (eg, Purinethol) or Muromonab-CD3 (monoclonal ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com The Future of Monoclonal Antibodies Therapeutics: Innovation In … - Jul 1, 2006 ...of murine antibody production in 1975, which allowed the production of the first mAb to market; Johnson & Johnson's Orthoclone OKT3 (muromonab) in 1986. ... MarketResearch.com Gemcitabine (Systemic). - Jul 28, 2005 Leukeran) or Corticosteroids (cortisone-like medicine) or Cyclosporine (eg, Sandimmune) or Mercaptopurine (eg, Purinethol) or Muromonab-CD3 (monoclonal ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com BioWorld International Correspondent - May 18, 2005 A murine monoclonal antibody to the same target, Orthoclone OKT3 (muromonab-CD3), was developed by Johnson & Johnson, of New Brunswick, NJ, during the 1980s ... BioWorld Online - BioWorld Online Cyclosporine (Systemic). - Feb 1, 2006 Leukeran) or Corticosteroids (cortisone-like medicine) or Cyclophosphamide (eg, Cytoxan) or Mercaptopurine (eg, Purinethol) or Muromonab-CD3 (monoclonal ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com Gemcitabine (Systemic). - Oct 27, 2005 Leukeran) or Corticosteroids (cortisone-like medicine) or Cyclosporine (eg, Sandimmune) or Mercaptopurine (eg, Purinethol) or Muromonab-CD3 (monoclonal ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com Transplantation, May 2005 - Jun 28, 2005 ...were managed with cyclosporine CsA and mycophenolate mofetil-based immunosuppression without either muromonab-CD3 or antithymocyte globulin induction. ... Medscape Alternative donor bone marrow transplant for children with Philadelphi... - Nov 7, 2005 Complement-mediated T-cell depletion of bone marrow: comparison of T10B9.1A-31 and Muromonab-Orthoclone OKT3. Cytotherapy 2001; 3: 467–481. ... Nature.com Brand Names/Synonyms: Muromonab is also known by the following brand names and/or synonymsOrthoclone OKT3; antiCD3; Orthoclone OKT3 (Ortho Biotech) Drug Category: Muromonab is categorized under the following by the FDA: Immunosuppressants; Immunomodulatory Agents; unclassified therapeutic agents (92:00.00) Dosage Forms: SOLUTION Absorption: Not Available Interactions: Not Available Chemical IUPAC Name: Murine anti-CD3 antibody |
|
Health Home | Conditions | Cancer | Medications | Surgery | Vaccines The Cancer News Network
COPYRIGHT 2009 CANCERNEWSNETWORK | Privacy |