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MustargenThis page contains recent news articles, when available, and an overview of Mustargen but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.Overview: Mustargen (when available) Mechlorethamine is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer. Alkylating agents are so named because of their ability to add alkyl groups to many electronegative groups under conditions present in cells. They stop tumor growth by cross-linking guanine bases in DNA double-helix strands - directly attacking DNA. This makes the strands unable to uncoil and separate. As this is necessary in DNA replication, the cells can no longer divide. In addition, these drugs add methyl or other alkyl groups onto molecules where they do not belong which in turn inhibits their correct utilization by base pairing and causes a miscoding of DNA. Alkylating agents are cell cycle-nonspecific. Alkylating agents work by three different mechanisms all of which achieve the same end result - disruption of DNA function and cell death. For the palliative treatment of Hodgkin’s disease (Stages III and IV), lymphosarcoma, chronic myelocytic or chronic lymphocytic leukemia, polycythemia vera, mycosis fungoides, and bronchogenic carcinoma. Mechanism Of Action: Alkylating agents work by three different mechanisms: 1) attachment of alkyl groups to DNA bases, resulting in the DNA being fragmented by repair enzymes in their attempts to replace the alkylated bases, preventing DNA synthesis and RNA transcription from the affected DNA, 2) DNA damage via the formation of cross-links (bonds between atoms in the DNA) which prevents DNA from being separated for synthesis or transcription, and 3) the induction of mispairing of the nucleotides leading to mutations. News Articles on Mechlorethamine Diamondback Drugs Provides Relief for Recent Veterinary Drug Shortages - Nov 10, 2009 Other medications include Mustargen, an oncology product that inhibits the growth of cancer cells, as well as Vetsulin, a type of insulin used to control ... PR Web (press release) Rupture de stock de CARYOLYSINE : difficultés d'approvisionnement en MUSTARGEN ... - Nov 13, 2009 ...(Agence française de sécurité sanitaire des produits de santé), signale des difficultés d'approvisionnement en MUSTARGEN jusqu'en janvier 2010. ... Le Généraliste (Abonnement) A Cancer Drug's Big Price Rise Is Cause for Concern - Mar 12, 2006 For instance, Ms. Elkins has a severe case of lymphoma and must cover much of her body with Mustargen each day, a process that requires her to refill her ... New York Times DRUG COMPANIES' PRICE GOUGING NEEDS TO BE EXAMINED. - Mar 17, 2006 Take the case of Mustargen, which is used to treat a rare form of lymphoma. ... When Mustargen is used as a topical ointment for a rare form of cancer, ... $3.50 - Press Telegram - NewsBank Sharp hike in some Rx prices rankles hospitals. - Apr 17, 2006 Cogentin, Diuril, Indocin, and Mustargen were recently sold to Ovation by Merck, and Panhematin was purchased by Ovation from Abbott. ... $9.94 - Drug Topics - Alacra Store Tales of pharmaceutical profiteering - Aug 4, 2006 Earlier this year Ovation Pharmaceuticals bought the right to manufacture and market the cancer drug Mustargen from Merck. In less than a month, ... Topeka Capital-Journal - Topeka Capital Journal Prescription Politics - Jul 24, 2006 Earlier this year Ovation Pharmaceuticals bought the right to manufacture and market the cancer drug Mustargen from Merck. In less than a month the cost of ... dissidentvoice.org Prescription politics: Surge in drug prices follows Republican... - Jul 27, 2006 Earlier this year Ovation Pharmaceuticals bought the right to manufacture and market the cancer drug Mustargen from Merck. In less than a month the cost of ... pww.org Prescription Politics - Jul 22, 2006 Earlier this year Ovation Pharmaceuticals bought the right to manufacture and market the cancer drug Mustargen from Merck. In less than a month the cost of ... politicalaffairs.net Mass media: cereal offender. - Apr 1, 2006 The Times told the tale of a woman in Texas who would now struggle to pay for Mustargen because her insurance didn't cover it. After reading the story, ... $9.94 - Medical Marketing & Media - Alacra Store Ferguson v. Merck & Co., Inc., No. 05-0451 (EDPa. 01/23/2008) - Jan 23, 2008 Ferguson believes Murphy was racially discriminatory in not following the safety protocols because Murphy was able to assign who went into the Mustargen ... $2.95 - U.S. District Court, Eastern District... - VersusLaw Congress decries drug price-gouging - Jul 28, 2008 It bought three other Merck meds--Cosmegen, Diuril Sodium, and Mustargen--and boosted those prices by 3437 percent, 864 percent, and 979 percent, ... FiercePharma Genentech finds high drug prices stick to teflon image - Apr 3, 2006 The story focused on a tenfold increase in the price for nitrogen mustard, a cancer drug marketed as Mustargen, after Ovation Pharmaceuticals bought the ... Bizjournals.com Wholesale prices for Rx up 7% in '07.(NEWS) | Article from Medical … - Apr 1, 2008 Medical Marketing & Media; April 1, 2006 ; 700+ words ... ... about Ovation Pharmaceuticals having bought two cancer treatments from Merck (Mustargen and ... Pay-Per-View - Medical Marketing & Media - HighBeam Research Webb v. Merck & Co., Inc., No. 99-413 (EDPa. 09/08/2006) - Sep 8, 2006 He also received training in the thawing of pharmaceutical products, checking vials for defects, and working on the mustargen line, the production line, ... $2.95 - U.S. District Court, Eastern District... - VersusLaw Loislaw Federal District Court Opinions - FERGUSON v. MERCK & CO., … - Jan 23, 2008 Ferguson believes Murphy was racially discriminatory in not following the safety protocols because Murphy was able to assign who went into the Mustargen ... Pay-Per-View - Loislaw Federal District Court Opinions - Loislaw Vesicant extravasation Part II: evidence-based management and … - Nov 1, 2006 ...self-limiting hypersensitivity responses along peripheral veins to an anthracycline or mechlorethamine (Mustargen[R], Ovation Pharmaceuticals, ... Free with registration - Oncology Nursing Forum - AccessMyLibrary.com Loislaw Federal District Court Opinions - WEBB v. MERCK & CO., INC. (... - Sep 8, 2006 He also received training in the thawing of pharmaceutical products, checking vials for defects, and working on the mustargen line, the production line, ... Pay-Per-View - Loislaw Federal District Court Opinions - Loislaw Brand Names/Synonyms: Mustargen is also known by the following brand names and/or synonymsCaryolysin; Caryolysine; Chlorethazine; Chlormethine; Cloramin; Dichlor Amine; Dichloren; Embichin; HN2; MBA; Mechlorethamine; Mechloroethamine; Mecloretamina; Mustargen; Mustine; Mustine Note; Mutagen; NSC 762; Nitrogen Mustard; T-1024; TL 146 Drug Category: Mustargen is categorized under the following by the FDA: Antineoplastic Agents; Chemical Warfare Agents; Alkylating Agents; ATC:L01A Dosage Forms: Powdered vials for injection, skin solution and ointment Absorption: Mechlorethamine is incompletely absorbed following intracavitary administration, probably because of rapid deactivation by body fluids. Interactions: [an error occurred while processing this directive] Chemical IUPAC Name: 2-chloro-N-(2-chloroethyl)-N-methyl-ethanamine |
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