Mycobutin

This page contains recent news articles, when available, and an overview of Mycobutin but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Mycobutin
(when available)

Pharmacology and use:
Rifabutin is an antibiotic that inhibits DNA-dependent RNA polymerase activity in susceptible cells. Specifically, it interacts with bacterial RNA polymerase but does not inhibit the mammalian enzyme. It is bactericidal and has a very broad spectrum of activity against most gram-positive and gram-negative organisms (including Pseudomonas aeruginosa) and specifically Mycobacterium tuberculosis. Because of rapid emergence of resistant bacteria, use is restricted to treatment of mycobacterial infections and a few other indications. Rifabutin is well absorbed when taken orally and is distributed widely in body tissues and fluids, including the CSF. It is metabolized in the liver and eliminated in bile and, to a much lesser extent, in urine, but dose adjustments are unnecessary with renal insufficiency. Used to prevent mycobacterial infection in immunocompromised patients, as a therapy in non-tuberculous mycobacterial infection, and as a treatment in pulmonary tuberculous.

Mechanism Of Action:
Rifabutin acts via the inhibition of DNA-dependent RNA polymerase, leading to a suppression of RNA synthesis and cell death.

News Articles on Rifabutin

Lower Doses of Mycobutin (Rifabutin), Every Other Day, May Offer as …  -  Dec 23, 2005
By Paula Moyer. WASHINGTON, DC -- December 23, 2005 -- Patients with advanced HIV who receive prophylactic rifabutin (Mycobutin) along with highly active ... DG News

Rifampin, Isoniazid, and Pyrazinamide (Systemic).  -  Aug 1, 2006
Trecator-SC), pyrazinamide, niacin (eg, Nicobid, nicotinic acid), rifampin (eg, Rifadin), rifabutin (eg, Mycobutin), or isoniazid (eg, INH, Nydrazid). ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Article: Don't let this happen to you.(FEEDBACK) - Macworld |...  -  May 1, 2005
After reviewing new data on rifabutin (Mycobutin), the U.S. Food and Drug ... (See "Mycobutin Approved to Prevent MAC," in the Updates section of the April ... Pay-Per-View - Macworld - HighBeam Research

Ã?ndice de lecciones  -  Mar 1, 2008
Aptivus/ritonavir también puede aumentar los niveles en la sangre de Mycobutin (rifabutin). Si tomas Mycobutin al mismo tiempo que estás tomando ... AIDSmeds.com HIV/AIDS Treatment News

Intelence (etravirine, TMC-125)  -  Jan 18, 2008
Si Intelence se usa con un inhibidor de la proteasa potenciado con Norvir, no se debe usar Mycobutin. Si Intelence se usa con un inhibidor de la proteasa ... AIDSmeds.com HIV/AIDS Treatment News

Retrovir (zidovudine, AZT)  -  Mar 1, 2008
Rifadin (rifampin) y Mycobutin (rifabutin) pueden disminuir los niveles de Retrovir ... Si necesitas tomar Rifadin o Mycobutin, puede ser necesario cambiar ... AIDSmeds.com HIV/AIDS Treatment News

Mycobacterium avium Complex (MAC)  -  Jun 9, 2005
Rifabutin (Mycobutin®) ha demostrado ser muy efectivo, pero puede tener interacciones negativas con otros medicamentos, especialmente con los inhibidores de ... AIDSmeds.com HIV/AIDS Treatment News

Ã?ndice de lecciones  -  Mar 10, 2008
Viracept puede aumentar los niveles de Mycobutin (rifabutin) y éste disminuye los niveles de Viracept (la dosis de Mycobutin se debe reducir a 150 mg ... AIDSmeds.com HIV/AIDS Treatment News

Article: If it isn't something, it's something else ...(nontuberculous...  -  Feb 1, 2006
Article: MYCOBUTIN PREVENTS ONSET OF AIDS-RELATED INFECTION ... Mycobutin to placebo in preventing disseminated MAC infection in PWAs who have CD4 counts of ... Pay-Per-View - Southern Medical Journal - HighBeam Research

Ã?ndice de lecciones  -  Mar 1, 2008
Rescriptor puede aumentar los niveles de Mycobutin (rifabutin) y Mycobutin puede disminuir los niveles de Rescriptor (estos medicamentos no se deben usar ... AIDSmeds.com HIV/AIDS Treatment News

Tuberculosis, a neglected opportunity?  -  Nov 2, 2006
In 2001, Pharmacia (now Pfizer) introduced rifabutin (Mycobutin), a rifampicin derivative that, unlike rifampicin, is not associated with significant ... Nature.com

Abbott Receives US Food and Drug Administration Approval for New …  -  Nov 12, 2007
...oral contraceptives ("the pill") or the contraceptive patch, Mycobutin(R) (rifabutin), inhaled Flonase(R) (fluticasone), metronidazole, or disulfiram. ... Free with registration - PR Newswire - AccessMyLibrary.com

雅培通过FDA 对其新的低浓度Kaletra(洛匹那韦ï¼?利托那韦)è?¯ç‰‡æ²»ç–—å„¿ç«¥ …  -  Nov 13, 2007
...���孕�或�孕贴片�Mycobutin(R)(利�布汀(rifabutin))��入�Flonase(R)( 氟替��(fluticasone))�甲�唑(metronidazole) 或�硫仑(disulfiram)。 ... 金�界

YOUR VIEWS | Article from The Record (Bergen County, NJ) | HighBeam …  -  Feb 14, 2006
Our 22-year-old son with Crohn's disease has been taking two antibiotics (mycobutin-rifabutin and biaxin-clarithromycin) effective against MAP and is now ... Pay-Per-View - The Record - HighBeam Research

Abbott Terima Persetujuan dari Badan Makanan dan Obat AS Untuk …  -  Nov 13, 2007
...atau plester kontraseptif, Mycobutin ? (rifabutin), Flonase hisap? (fluticasone), metronidazole, atau disulfiram. Pasien harus berbicara dengan dokter ... ANTARA

Efavirenz (Systemic).  -  Jul 28, 2005
...which may lead to severe drowsiness Rifabutin (eg, Mycobutin) -- Efavirenz may decrease the amount of this medicine in the body Ritonavir (eg, ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

How to take Bortezomib from Consumer Reports Health.  -  Jan 8, 2007
...phenobarbital (Luminal, Solfoton), or phenytoin (Dilantin, Phenytek); mibefradil (no longer available in the US); nefazodone; rifabutin (Mycobutin); ... consumerreports.org

Tibotec's Intelence (Etravirine, TMC125) is Approved by FDA  -  Jan 18, 2008
...the antibiotics Rifadin (rifampin), Priftin (rifapentine) and Mycobutin (rifabutin); or products containing St. John's wort (Hypericum perforatum). ... AIDSmeds.com HIV/AIDS Treatment News

How to take Sildenafil from Consumer Reports Health.  -  Jan 12, 2007
Epitol, Tegretol), phenobarbital, and phenytoin (Dilantin, Phenytek); rifabutin (Mycobutin); and rifampin (Rifadin, Rimactane). ... consumerreports.org

Delavirdine (Systemic).(Drug overview)  -  Aug 1, 2006
Methergine) or Midazolam (eg, Versed) or Phenobarbital or Phenytoin (eg, Dilantin) or Pimozide (eg, Orap) or Rifabutin (eg, Mycobutin) or Rifampin (eg, ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Fludrocortisone (Systemic).  -  Oct 27, 2005
Viramune) or Phenylbutazone (eg, Butazolidin) or Phenytoin (eg, Dilantin) Primidone (eg, Mysoline) or Rifabutin (eg, Mycobutin) or Rifampin (eg, ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Sirolimus (Systemic).  -  Feb 1, 2006
Tegretol) or Rifabutin (eg, Mycobutin) or Rifampin (eg, Rifadin) or Rifapentine (eg, Priftin) St. John's wort -- May decrease the effects of sirolimus ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Progestins --For Noncontraceptive Use (Systemic).  -  Oct 27, 2005
Aminoglutethimide (e.g., Cytadren) or Carbamazepine (e.g., Tegretol) or Phenobarbital or Phenytoin (e.g., Dilantin) or Rifabutin (e.g., Mycobutin) or ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Abbott Study Shows Investigational Heat-Stable Norvir(R) Tablet...  -  Aug 8, 2008
Levitra(R) (vardenafil), oral contraceptives ("the pill") or the contraceptive patch, Mycobutin(R) (rifabutin), rifampin, also known as Rimactane(R), ... presseportal.de

Atazanavir (Systemic).  -  Feb 1, 2006
Brevicon, Loestrin, Modicon, Ortho-Novum) or Quinidine (eg, Cardioquin, Quinidex Extentabs) or Rifabutin (eg, Mycobutin) or Saquinavir (eg, Fortovase, ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Echinocandins offer antifungal therapy with low toxicity, few drug...  -  May 15, 2005
Several agents lower serum levels of itraconazole, including phenytoin, phenobarbital, rifampin, and rifabutin (Mycobutin), but "remember that itraconazole ... Free with registration - Internal Medicine News - AccessMyLibrary.com

XDR-TB Rate Holding Steady After Decline  -  Nov 14, 2008
...and 95% of them had drug susceptibility results reported for isoniazid (Nydrazid) and a rifamycin, either rifampin (Rifadin) or rifabutin (Mycobutin). ... MedPage Today

Efavirenz (Systemic).(Drug overview)  -  May 1, 2006
...which may lead to severe drowsiness Rifabutin (eg, Mycobutin) -- Efavirenz may decrease the amount of this medicine in the body Ritonavir (eg, ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Rifampicin resistance linked to dosing schedule in HIV-positive TB …  -  Jun 13, 2005
The study also showed that the risk of resistance was not affected by whether the patients took rifampicin or the similar drug rifabutin (Mycobutin). ... Aidsmap

COMUNICADO: Abbott recibe la aprobación de la FDA para la tableta de ...  -  Nov 13, 2007
Levitra(R) (vardenafil), anticonceptivos orales ("la píldora") o el parche anticonceptivo, Mycobutin(R) (rifabutin), Flonase(R) inhalada (fluticasone), ... elEconomista.es

How to take Fentanyl Transdermal from Consumer Reports Health.  -  Jan 4, 2008
...rifabutin (Mycobutin); rifampin (Rifadin, Rimactane, in Rifamate); sedatives; sleeping pills; tranquilizers; or verapamil (Calan, Covera, Verelan). ... consumerreports.org

Rifapentine (Systemic).  -  Feb 1, 2006
Tell your doctor if you have ever had any unusual or allergic reaction to rifabutin (eg, Mycobutin), rifampin (eg, Rifadin), or rifapentine. ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Estrogens and Progestins Oral Contraceptives (Systemic ).  -  Oct 27, 2005
Dilantin) or Plicamycin (eg, Mithracin) or Primidone (eg, Mysoline) or Rifabutin (eg, Mycobutin) or Rifampin (eg, Rifadin) or Troleandomycin (eg, ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Sirolimus (Systemic).(Drug overview)  -  Aug 1, 2006
Carbamazepine (eg, Tegretol) or Rifabutin (eg, Mycobutin) or Rifampin (eg, Rifadin) or Rifapentine (eg, Priftin) St. John's wort -- May decrease the effects ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

How to take Temsirolimus from Consumer Reports Health.  -  Jan 1, 2008
Tegretol), phenobarbital (Luminal),and phenytoin (Dilantin, Phenytek); medications to lower cholesterol and lipids; nefazodone; rifabutin (Mycobutin); ... consumerreports.org

Abbott krijgt goedkeuring van de Food and Drug Administration voor …  -  Nov 13, 2007
...anticonceptiemiddelen ("de pil") of de anticonceptiepleister, Mycobutin(R) (rifabutin), inhailer Flonase(R) (fluticasone), metronidazole, of disulfiram. ... Hiv Vereniging Nederland

Rifapentine (Systemic).(Drug overview)  -  May 1, 2006
Tell your doctor if you have ever had any unusual or allergic reaction to rifabutin (eg, Mycobutin), rifampin (eg, Rifadin), or rifapentine. ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

How to take Erlotinib from Consumer Reports Health.  -  Jan 12, 2008
...lansoprazole (Prevacid), omeprazole (Prilosec), pantoprazole (Protonix), and rabeprazole (AcipHex); rifabutin (Mycobutin); rifampin (Rifadin, ... consumerreports.org

Management of active tuberculosis.(Disease/Disorder overview)(Cover …  -  Dec 1, 2005
In addition, several others that have not been approved are used commonly, including certain fluoroquinolones, rifabutin (Mycobutin), amikacin (Amikin), ... $4.95 - American Family Physician - ECNext

Update on Helicobacter pylori treatment.(control of bacterial...  -  Feb 1, 2007
...(43) Regimens that include rifabutin (Mycobutin), 300 mg per day, also have been successful in 38 percent of resistant cases. (42) RECURRENCE ... $4.95 - American Family Physician - ECNext

How is it treated or prevented?  -  Jun 6, 2006
Rifampin (Rifamate®) or rifabutin (Mycobutin®): Rifampin is actually the preferred choice. However, this drug does not combine well with many protease ... AIDSmeds.com HIV/AIDS Treatment News

How to take Fentanyl Buccal (Transmucosal) from Consumer Reports …  -  Jan 1, 2008
...phenytoin (Dilantin, Phenytek); rifabutin (Mycobutin); rifampin (Rifadin, Rimactane, in Rifamate); sedatives; sleeping pills; and tranquilizers. ... consumerreports.org

How to take Toremifene from Consumer Reports Health.  -  Jan 1, 2008
...nefazodone; phenobarbital; phenytoin (Dilantin, Phenytek); rifabutin (Mycobutin); rifampin (Rifadin, Rimactane); and verapamil (Calan, Covera, Verelan). ... consumerreports.org

Rifampin, Isoniazid, and Pyrazinamide (Systemic).(Drug overview)  -  May 1, 2006
Trecator-SC), pyrazinamide, niacin (eg, Nicobid, nicotinic acid), rifampin (eg, Rifadin), rifabutin (eg, Mycobutin), or isoniazid (eg, INH, Nydrazid). ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

PROGESTIN CONTRACEPTIVE (Oral route, Implantation route, …  -  May 1, 2007
Rifabutin (e.g., Mycobutin) * Rifampin (e.g., Rifadin) Sometimes your doctor may use these medicines with progestins for contraception but will give you ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Clarithromycin (Systemic).(Drug overview)  -  May 1, 2006
Rifabutin (eg, Mycobutin) or Rifampin (eg, Rifadin) -- Rifabutin or rifampin may decrease the amount of clarithromycin in the blood Sildenafil (eg, ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Atovaquone and Proguanil ( Systemic).(Drug overview)  -  May 1, 2006
Rifabutin (eg, Mycobutin) or Rifampin (eg, Rifadin) -- Use of rifampin may decrease the amount of atovaquone in the blood and keep it from working properly ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Arkansas Regulations - 124.180 Tuberculosis (TB)  -  Apr 2, 2008
...category: Capreomycin/1 gm vial Mycobutin/150 mg capsules Ethambutol/400 mg tablets Pyrazinamide/500 mg tablets Isoniazid/100 mg tablets Rifampin/150 mg ... Pay-Per-View - Arkansas Regulations - Loislaw

Mycobacterium avium Complex (MAC)  -  Dec 15, 2008
Rifabutin (Mycobutin) ha demostrado ser muy efectivo, pero puede tener interacciones negativas con otros medicamentos, especialmente con los inhibidores de ... AIDSmeds.com HIV/AIDS Treatment News

Mycobacterium kansasii  -  Jun 6, 2006
Rifampin (Rifamate) o rifabutin (Mycobutin): En realidad, rifampin es la mejor opción. Sin embargo, este medicamento no se combina bien con muchos ... AIDSmeds.com HIV/AIDS Treatment News

Brand Names/Synonyms:
Mycobutin is also known by the following brand names and/or synonymsANSAMYCIN; Alfacid; Ansamycin; Ansatipin; Ansatipine; Antibiotic Lm 427; Mycobutin; RBT; RIFABUTIN; Rifabutin; Rifabutina [Spanish]; Rifabutine [French]; Rifabutinum [Latin]

Drug Category:
Mycobutin is categorized under the following by the FDA: Antibiotics; Anti-bacterial Agents; Antituberculosis Agents; ATC:J04AB04

Dosage Forms:
CAPSULE

Absorption:
Following a single oral dose of 300 mg to nine healthy adult volunteers, rifabutin was readily absorbed from the gastrointestinal tract. Absolute bioavailability averaged 20%.

Interactions:
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Chemical IUPAC Name:
(9S,12E,14S,15R,16S,17R,18R,19R,20S,21S,22E,24Z)-6,16,18,20-Tetrahydroxy-1'-isobutyl-14-methoxy-7,9,15,17,19,21,25-hepta-methyl-spiro[9,4-(epoxypentadeca[1,11,13]trienimino)-2H-furo-[2',3':7,8]-naphth[1,2-d]imidazol-2,4'-piperidin]-5,10,26-(3H,9H)-trione 16-acetate





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