Naltrexone

This page contains recent news articles, when available, and an overview of Naltrexone but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Naltrexone
(when available)

Pharmacology and use:
Naltrexone, a pure opioid antagonist, is a synthetic congener of oxymorphone with no opioid agonist properties. Naltrexone is indicated in the treatment of alcohol dependence and for the blockade of the effects of exogenously administered opioids. It markedly attenuates or completely blocks, reversibly, the subjective effects of intravenously administered opioids. When co-administered with morphine, on a chronic basis, Naltrexone blocks the physical dependence to morphine, heroin and other opioids. In subjects physically dependent on opioids, Naltrexone will precipitate withdrawal symptomatology. For treatment of opioid type drug dependence.

Mechanism Of Action:
Naltrexone binds to the opioid mu receptor antagonistically, thereby preventing conventional opiate (heroin, morphine) drugs from binding and inducing opioid neural responses. The mechanism of action of Naltrexone in alcoholism is not understood; however, involvement of the endogenous opioid system is suggested by preclinical data. Naltrexone competitively binds to such receptors and may block the effects of endogenous opioids.

News Articles on Naltrexone

Julie's Low Dose Naltrexone Journal: Stopping LDN (for Now)  -  ‎Jan 4, 2010‎
As I wrote in my last couple of blog posts describing my experiences with low dose naltrexone (LDN) to address some of my multiple sclerosis (MS) symptoms, ... About - News & Issues (blog)

The fine line between alcoholism, drinking too much  -  ‎Jan 4, 2010‎
The drug, naltrexone, acts to block brain receptors for those opioids, making it easier for patients to remain abstinent or stop quickly if they slip. ... Abilene Reporter-News

The New Year Can Be the Best Time to Tackle Drug and Alcohol Addiction  -  ‎Dec 30, 2009‎
It's noted for its use of the Accelerated Detox Technique (ADT) in combination with opiate-blocking Naltrexone Implant therapy to treat addiction, ... PR-inside.com (press release)

Kathleen I. Kelly  -  ‎Dec 31, 2009‎
Email: kathleen.kelly{at}obmh.nhs.uk In the first randomised controlled trial of naltrexone implants, Kunøe et al 1 identify two inclusion criteria in their ... British Journal of Psychiatry

Abrupt end to eating, drinking and being merry  -  ‎Jan 4, 2010‎
In addition, the opioid blocking agent naltrexone has been shown to reduce cravings for sweet food as well as heroin-like drugs. ... Irish Times

King's all kid gloves on Embeda launch  -  ‎Dec 10, 2009‎
Embeda is an extended-release analgesic combining morphine sulfate with naltrexone, a substance designed to reduce morphine's effect. ... Medical Marketing and Media

Implant boosts heroin abstinence  -  ‎Dec 14, 2009‎
A heroin treatment trial using sustained release naltrexone may offer new hope for addicts by giving them more time to get their lives in order. ... The Virtual Medical Centre

Compulsive Gambling Increases as Gambling Opportunities Proliferate  -  ‎Jan 4, 2010‎
The opiate antagonists Nalmefene and Naltrexone, medications used to treat substance additions, have been shown to help treat pathological gambling. ... Melodika.net

Arena files for approval for weight loss drug  -  ‎Dec 22, 2009‎
Contrave, which combines the antidepressant Wellbutrin, known generically as bupropion, with naltrexone, an opioid blocker used to treat alcoholism. ... Reuters

Compulsive Gambling Increase as Gambling Opportunities Proliferate  -  ‎Jan 2, 2010‎
The opiate antagonists Nalmefene and Naltrexone, medications used to treat substance additions, have been shown to help treat pathological gambling. ... PR Web (press release)

Addiction Meds May Help Gamblers  -  ‎Dec 10, 2009‎
The first group -- those driven by urge -- responded well to medications that block the brain opioid system (such as naltrexone) or certain receptors for ... U.S. News & World Report

Ask the Doctor: Why am I suddenly feeling dizzy?  -  ‎Dec 28, 2009‎
Because the patient was critical, he administered an unconventional emergency treatment with a drug called Naltrexone. The patient improved, and shortly ... Daily Mail

Food addiction underrecognized, argue some  -  ‎Dec 22, 2009‎
In other cases, medications like naltrexone may help control the cravings. For Darren, after he eliminated sugar and flour from his diet, ... CTV.ca

Pharmacotherapy for borderline personality disorder: Cochrane systematic ...  -  ‎Dec 31, 2009‎
...future: most ongoing trials are testing different drugs, such as the SGA quetiapine, the SSRI sertraline or the opioid receptor antagonist naltrexone. ... British Journal of Psychiatry

Program Characteristics Associated With Testing for HIV and Hepatitis C in ...  -  ‎Dec 31, 2009‎
Evidence-based medication therapy was a dichotomous variable, where 1 indicated use of any of five treatments (methadone, buprenorphine, or naltrexone for ... Psychiatric Services (subscription)

새로운 비만치료제, 美FDA 신약신청 제출  -  ‎Dec 23, 2009‎
...í??넥사는 간질약 토피ë?¼ë©”ì?´íЏ(topiramate)와 펜터민(phentermine) 복합제ì?´ê³  콘트ë?¼ë¸ŒëŠ” 항우울제ì?¸ '웰부트린(Wellbutrin)'ê³¼ 날트렉ì†?(naltrexone) 복합제ì?´ë‹¤. ... 데일리팜

Estudo brasileiro descobre remédio que ajuda a atacar os dois males de uma vez só  -  ‎Dec 10, 2009‎
Ele comparou o efeito do medicamento com o de outro popular remédio de combate ao alcoolismo, o naltrexone. As pílulas foram administradas a 155 homens ... Galileu

Une molécule anti-«Binge drinking» à l'essai  -  ‎Dec 22, 2009‎
Le nalméfène «est une molécule très proche d'une molécule déjà sur le marché dans le traitement de l'alcoolo-dépendance, la naltrexone», a précisé le ... 20minutes.fr

Le Qnexa et le Lorcaserin, médicaments pour la perte de poids, soumis à la FDA  -  ‎Dec 29, 2009‎
Ce médicament est une combinaison de bupropion (Wellbutrin, un antidépresseur notamment utilisé pour aider le sevrage tabagique) et naltrexone (Revia ou ... PsychoMédia

Những cá»±u binh chống ma túy  -  ‎Dec 23, 2009‎
Duy đã áp dụng và kết hợp linh động nhiá»?u giải pháp như cắt cÆ¡n, giải độc, giáo dục nhận thức tâm lý, Ä‘iá»?u trị chống tái nghiện bằng thuốc NalTrexone. ... Báo Bạn Đường

Le nalméfène (Revex), médicament contre l'abus d'alcool, à l'essai en France  -  ‎Dec 22, 2009‎
...le traitement de l'alcoolo-dépendance, la naltrexone (commercialisée sous différents noms: ReVia, Depade, Nalorex et Vivitrol), précise le chercheur. ... PsychoMédia

Препарати Ñ?рещу наркомании помагат и при патологично комарджийÑ?тво 11 декември ...  -  ‎Dec 12, 2009‎
Било уÑ?тановено, че лицата от първата група Ñ?е повлиÑ?ват най-добре от naltrexone и memantine, докато пациентите от втората група реагират на tolcapone. ... DoctorBG.com

Jeu pathologique: deux types de joueurs, deux médicaments contre la ...  -  ‎Dec 11, 2009‎
Le premier groupe répondait bien à un traitement avec des médicaments qui bloquent le système opioïde du cerveau (ex. la naltrexone) ou certains récepteurs ... PsychoMédia

New alcoholism drug gives addicts a chance  -  ‎Nov 12, 2009‎
Vivitrol is a new, extended-release, injectable form of Naltrexone for the treatment of alcohol dependence. It works by blocking the opiate receptors and ... St. Joseph News-Press

Campaign for drugs trial gathers pace  -  ‎Nov 12, 2009‎
Jayne Crocker and her partner Andrew Barnett both take Low Dose Naltrexone (LDN), a generic drug which is currently out of patent. ... Milford Mercury

Addicts' drug has changed my life, says MS sufferer  -  ‎Nov 13, 2009‎
Naltrexone was designed to help hard drug addicts break their habit. But a New York doctor treating drug addicts with HIV noticed that it also helped ... Edinburgh Evening News

Julie's Low Dose Naltrexone Journal: Month 6  -  ‎Nov 2, 2009‎
There is bad news and good news to report about my experiences with low dose naltrexone (LDN) to help with my symptoms of multiple sclerosis (MS). ... About - News & Issues (blog)

COR trials: Combination bupropion, naltrexone improved cardiometabolic risk ...  -  ‎Oct 29, 2009‎
Patients were randomly assigned to receive either bupropion SR/naltrexone SR (Contrave32) or placebo, with a four-week titration period. ... Endocrine Today

How can alcoholism be managed?  -  ‎Nov 12, 2009‎
It is also his paranoia that needs to be addressed so a cocktail of Thorazine, valproic acid,along with Disulfiram and Naltrexone or Thorazine, ... DoctorNDTV

Paying for Alternative Treatments  -  ‎Nov 13, 2009‎
Burt Berkson, MD, PhD, has been extremely successful treating cancer with a combination of intravenous alpha lipoic acid and oral low dose naltrexone, ... New York Times (blog)

Orexigen(R) Therapeutics Announces Contrave(R) Data Presentations at Annual ...  -  ‎Oct 21, 2009‎
...the schedule of its upcoming Contrave® (naltrexone SR/bupropion SR) data presentations at the 27th Annual Scientific Meeting of The Obesity Society. ... Reuters

FDA Sends Warning Letter to King Pharmaceuticals Over Embeda Videos  -  ‎Oct 21, 2009‎
EMBEDA is an extended-release oral formulation of morphine sulfate and naltrexone hydrochloride recently approved for the management of moderate to severe ... PharmaLive.com (press release)

Contrave - experimental diet drug yields positive results  -  ‎Oct 26, 2009‎
Interestingly enough, Contrave combines Wellbutrin, an antidepressant, with naltrexone, a drug that is used to treat alcoholism and other addictions. ... Examiner.com

Companies Race To Bring Diet Drugs To Market  -  ‎Oct 28, 2009‎
Essentially, bupropion stimulates cells in the hypothalamus, a regulatory center in the brain, that curb appetite, and the naltrexone blocks endorphins, ... NPR

Grant awarded for research into a new treatment for methamphetamine addiction  -  ‎Nov 6, 2009‎
One of the emerging medications for treating methamphetamine addiction is naltrexone, an FDA-approved treatment for heroin and alcohol dependence. ... News-Medical.net

MICHAEL J.FOX FOUNDATION FUNDS FOUR NEW APPROACHES FOR PARKINSON'S DISEASE  -  ‎Nov 13, 2009‎
Naltrexone, which blocks opioid receptors, is approved by the US Food and Drug Administration (FDA) for the treatment of alcohol dependence. ... Parkinson's Disease News

King Videos for Embeda Warned for Misleading  -  ‎Oct 30, 2009‎
The videos omitted the potential risk of death associated with the use of Embeda (morphine sulfate/naltrexone HCl) as described in the drug's boxed warning ... FDA news (subscription)

Orexigen obesity drug seems to be effective  -  ‎Oct 24, 2009‎
...famous commonly as bupropion, with a sustained- release version of naltrexone, an opioid blocker used to treat alcoholism and other addictions. ... What is the Word

MS drug could save NHS millions  -  ‎Oct 19, 2009‎
Low dose naltrexone, or LDN, is already available on the NHS but not all GPs are prepared to prescribe it to treat MS – naltrexone has been approved by the ... Nursing in Practice

Plea to fund drug helping MS sufferers  -  ‎Oct 26, 2009‎
Margaret Gachagan, of Garthamlock, is calling for the UK Government to fund trials of Low Dose Naltrexone. There is anecdotal evidence the drug could also ... Glasgow Evening Times

Orexigen(R) Therapeutics Announces Third Quarter 2009 Financial Results  -  ‎Nov 4, 2009‎
These new data show that after completing 56 weeks of therapy with Contrave32 (bupropion SR 360 mg/naltrexone SR 32 mg): -- Approximately 34-48% of patients ... Reuters

Yale Physicians Receive $4.1 Million Grant To Study New Treatment For Alcohol ...  -  ‎Oct 29, 2009‎
All subjects in the trial, whether getting naltrexone or the placebo, will receive comprehensive case-management services and 24 weeks of counseling. ... Medical News Today (press release)

3 new prescription diet drugs may soon help obese  -  ‎Oct 21, 2009‎
It combines two drugs now on the market — bupropion, an antidepressant and smoking cessation medication, and naltrexone, currently used for alcohol and ... USA Today

Market Watch  -  ‎Nov 5, 2009‎
It was developed with the abuse-deterrent drug naltrexone, which reduces euphoria when crushed or chewed.12 Pitavastatin 4 mg (Livalo) has been approved by ... The Hospitalist Online

Michael J. Fox Foundation Awards $2.2 Million to Four Clinical Trials for New ...  -  ‎Nov 10, 2009‎
Naltrexone, which blocks opioid receptors, is approved by the US Food and Drug Administration (FDA) for the treatment of alcohol dependence and has shown a ... Earthtimes (press release)

No Clear Winner as Top Obesity Candidates Reveal Detailed Data  -  ‎Oct 26, 2009‎
...while Orexigen Therapeutics Inc.'s Contrave (bupropion SR/naltrexone SR) came in at 4.2 percent to 5.2 percent. Arena Pharmaceuticals Inc.'s lorcaserin, ... BioWorld Online

Orexigen(R) Therapeutics Releases New Efficacy Data for Contrave(R) in Late ...  -  ‎Oct 27, 2009‎
COR-I and COR-II Phase 3 trials of Contrave® (naltrexone SR/bupropion SR), the first of two late stage Orexigen candidates for the treatment of obesity. ... Reuters

Regulatory Roundup: FDA Authorizes Emergency Use of Investigational Drug for ...  -  ‎Oct 29, 2009‎
Letter to King Pharmaceuticals (Bristol, TN) over two video news releases for its painkiller Embeda (morphine sulfate and naltrexone hydrochloride). ... Pharmaceutical Technology Magazine

Orexigen(R) Therapeutics Presents New Data Showing Weight Loss with Contrave ...  -  ‎Oct 24, 2009‎
...new data from the COR-I, COR-II and COR-Diabetes trials for Contrave® (bupropion SR/ naltrexone SR) to expand on top-line results announced in July. ... Reuters

AIKO Biotechnology completes phase 1 human trial of lead compound AIKO-150  -  ‎Oct 30, 2009‎
Dose-proportional pharmacokinetics, similar to those expected from published studies of AIKO-150 as a human metabolite of naltrexone. ... pharmabiz.com

Combination drugs for weight loss  -  ‎Oct 29, 2009‎
MA) and colleagues presented data from a phase 3 randomized controlled trial comparing the efficacy and safety of naltrexone and bupropion (Orexigen ... TheHeart.Org

Labour will let the NHS pay for private care: why not the other way round?  -  ‎Oct 31, 2009‎
One drug that helps people tremendously with any autoimmune disease and some cancers is Low Dose Naltrexone – LDN. This slows down progression and in some ... Telegraph.co.uk

Alkermes 'Pops' Back in Gear: Cash Aplenty to Fuel Licensing  -  ‎Nov 6, 2009‎
Alkermes also markets alcohol-dependence drug Vivitrol (naltrexone for extended-release injectable suspension), which recorded modest net sales of $4.6 ... Therapeutics Daily (press release) (registration)

New weight loss drugs on the horizon!  -  ‎Nov 7, 2009‎
...an antidepressant and smoking cessation medication (also known as Zyban or Wellbutrin SR), and naltrexone, currently used for alcohol and opioid ... Drumheller Mail

Three new prescription diet drugs for the obese on FDA roadmap  -  ‎Oct 22, 2009‎
Contrave from Orexigen: combines two drugs, bupropion, an antidepressant and smoking cessation medication, and naltrexone, currently used for alcohol and ... ChattahBox

Bra Boy Jai Abberton locked up  -  ‎Oct 26, 2009‎
He also said he could not have been doing drugs because he was getting treatment for "an opiate dependency" that involved a naltrexone implant. ... NEWS.com.au

Davidson Professor's Grant Explores Exercise as Help for Cocaine Addiction  -  ‎Oct 28, 2009‎
..."For heroin there's methadone, for nicotine there's Chantix, and for alcohol there's naltrexone," he said. "But I think people will need some form of ... AScribe (press release)

Michael Cowley, Obesity Expert, Named Life Scientist Of The Year  -  ‎Oct 31, 2009‎
Contrave combines new formulations of two existing drugs: Bupropion, an antidepressant; and Naltrexone, an addiction medication. ... Medical News Today (press release)

비만실험약 '콘트ë?¼ë¸Œ' 3ìƒ?ìž„ìƒ? 목표 ë?„달  -  ‎Oct 25, 2009‎
...콘트ë?¼ë¸ŒëŠ” 항우울제 '웰부트린(Wellbutrin, bupropion)'ê³¼ 알코올 중ë?… 치료제로 사용ë?˜ëŠ” 날트렉ì†?(naltrexone)ì?˜ 복합제. 지난 7ì›” 발표ë?œ ìž?료ì—? 따르면 첫 번째 ... 데일리팜

La pilule Contrave de Orexigen fait perdre 10 à 15% de poids  -  ‎Oct 26, 2009‎
Bupropion est censé initier la perte de poids tandis que la naltrexone est censée soutenir la perte de poids en empêchant la tendance naturelle du corps à ... RegimesMaigrir.com

Комбинирана медикаментозна терапиÑ? е ефективна за отÑ?лабване 03 ноември 2009  -  ‎Nov 3, 2009‎
Във второто проучване били изÑ?ледвани безопаÑ?ноÑ?тта и ефективноÑ?тта на комбинациÑ?та от naltrexone и bupropion Ñ?рещу плацебо при 1496 пациенти. ... DoctorBG.com

항비만제 개발 3파전…비버스 ì„ ë‘?  -  ‎Oct 20, 2009‎
...한편, 오렉시젠ì?˜ '콘트레ì?´ë¸Œ'(Contrave, bupropion/ naltrexone)는 개발진ì—? 암젠 등 대형 제약사ì?˜ 베테랑들ì?´ í?¬ì§„í•´ 있다는 ì ?ì—?서 기대ë?œë‹¤. ... 디지틀보사

Monthly Injection Could Treat Alcoholism  -  Apr 6, 2005
A monthly shot of the prescription drug naltrexone — plus counseling — could help reduce ... The study was funded by Alkermes Inc., which makes naltrexone. ... FOXNews

Injectable alcoholism drug wins FDA approval  -  Apr 13, 2006
Naltrexone initially won FDA approval for treating alcoholism in 1994. ... The market for Antabuse and naltrexone has been limited, with annual sales in the ... msnbc.com

Call for naltrexone implant review  -  Apr 20, 2008
THE use of implants of the rapid detoxification drug naltrexone should be urgently reviewed after at least eight users ended up in hospital with side ... The Australian

Urgent review of naltrexone implants needed  -  Apr 21, 2008
...by Dr Linda Calabresi. I am confused by this. Other implants are used all the time (eg testosterone which is even on the PBS, even more common is Implanon) ... 6minutes

Naltrexone trial proposed in ACT  -  Jun 24, 2007
Key drug advisory groups and specialists will meet in Canberra today to discuss the idea of an ACT trial for the methadone substitute drug naltrexone. ... ABC Online - ABC Online

Heroin Detox Using Anesthesia Limited and Risky, Study Says  -  Aug 24, 2005
All patients were then offered 12 weeks of additional naltrexone therapy and psychotherapy designed to prevent a relapse into heroin use. ... Pay-Per-View - Los Angeles Times - ProQuest Archiver

Medical Attention, Therapy and Addiction Drugs Are Found to Help...  -  May 3, 2006
Some received the drug naltrexone, with or without regular therapy sessions; ... After four months, about three-quarters of those receiving naltrexone, ... New York Times

An Injection to Cure Holiday Drinking?  -  Dec 18, 2008
One answer for those trying to kick the habit is naltrexone, a once-a-day ... But there's one difficulty with naltrexone: In order for the pill to work, ... TIME

Potential of Buprenorphine/Naltrexone in Treating Polydrug Addiction...  -  Oct 30, 2007
In recent years, we have seen regulatory approval being given for several new pharmacotherapies in the treatment of drug addiction disorders. ... Nature.com

Naltrexone for alcohol abuse and dependence  -  Feb 15, 2008
Naltrexone is available in pill form. Vivitrol is taken as a shot (injection) into a muscle (intramuscular) once a month. Naltrexone is an opioid antagonist ... WebMD

Drug helps alcoholics without intensive counseling  -  May 3, 2006
The eight groups received either naltrexone, which costs $4 or $5 a day; acamprosate, ... The most effective: either naltrexone or psychotherapy. ... USA Today

Naltrexone implants safe, study shows  -  Oct 15, 2007
Heroin addicts treated with naltrexone implants are no more likely to overdose than those taking methadone, according to a new study from Perth. ... 6minutes

Promising medications lend hope to addicts seeking treatment.  -  Aug 8, 2005
Naltrexone has been around for 20 years, but few people know about it. ... Like naltrexone, it can be prescribed by private-practice physicians, ... Free with registration - St. Louis Post-Dispatch - AccessMyLibrary.com

Study: alcoholism drug diminishes gambling urge_English_Xinhua  -  Jun 5, 2008
Subjects who got naltrexone were much more likely to abstain from gambling than ... Moreover, low doses of naltrexone were as effective as higher doses. ... 新�网

Alcoholism hope over 'drug pill'  -  May 6, 2006
Naltrexone, which blocks craving, and intensive counselling had the best ... They tested two drugs - naltrexone and acamprosate, which are both aimed at ... BBC News

Alcoholism Drug Still Awaits Final Approval  -  Dec 28, 2005
Vivitrol, known as Vivitrex while it was being tested, is an injectable, extended-release version of naltrexone, a now-generic pill that's prescribed to ... TheStreet.com - TheStreet.com (subscription)

The great divide over detox  -  Dec 3, 2005
Before they leave, each will have a slow-release pellet of naltrexone ... It is critical because naltrexone wipes out the drug-tolerance patients have built ... Sydney Morning Herald

Drug addicts 'risk overdose in treatment'  -  Feb 4, 2007
Scientists have identified five deaths involving implantable naltrexone, ... Naltrexone implants were introduced in Australia a decade ago to get around the ... NEWS.com.au

FDA Issues Warning for Naltrexone Injection Site Reactions  -  Aug 12, 2008
ROCKVILLE, Maryland -- August 12, 2008 -- The US Food and Drug Administration (FDA) issued a notification to healthcare professionals of the risk of adverse ... DG News

Alkermes Has Surprise Profit  -  Feb 7, 2006
Vivitrol is an injectable, extended-release version of naltrexone, a pill that's ... Naltrexone and Vivitrol are given to alcoholics to discourage them from ... TheStreet.com - TheStreet.com (subscription)

Alcoholism Drugs Gain Popularity  -  Sep 13, 2005
Vivitrex is a reformulation of naltrexone that is administered by monthly ... Many insurers include the older treatments Antabuse and naltrexone on their ... CBS News

US panel sees some Alpharma pain drug benefit  -  Nov 14, 2008
It also has an inner core of naltrexone, a drug used to treat drug and alcohol withdrawal that reverses morphine's effect. Alpharma said studies showed the ... Reuters

Addicts' drug helps women quit  -  Oct 9, 2006
Among men, naltrexone had no identifiable effect. But among women it made a big difference. Without it, 39 per cent gave up smoking for a week; with it, ... Times Online

… pharmacokinetics of extended-release injectable naltrexone (XR...  -  Nov 1, 2007
One such pharmacologic agent is naltrexone, which blocks the effects of alcohol ... Following IM injection, naltrexone is released from the microspheres in ... Free with registration - Journal of Studies on Alcohol and Drugs - AccessMyLibrary.com

Cambridge firm readies push on alcoholism drug  -  Sep 4, 2005
Bauhs credits his sobriety to naltrexone, a drug he found out about while surfing ... Two other drugs have become available in the past decade: Naltrexone, ... Boston Globe

Naltrexone implants safe: WA study  -  Jul 31, 2008
...by Dr Linda Calabresi. New Australia data show naltrexone implants do not increase the risk of suicide or overdose, allaying previously held concerns about ... 6minutes

Medical management with naltrexone or behavioral therapy can …  -  May 7, 2006
By JAMA, Medical management combined with the drug naltrexone or with a specialized behavioral therapy can be effective treatments for alcohol dependence, ... RxPG NEWS

A trajectory-based analysis of naltrexone for alcohol dependence.(What...  -  Aug 1, 2007
...* Investigators used trajectory-based approach to reanalyze two negative clinical trials of naltrexone for alcohol dependence. ... Free with registration - Brown University Psychopharmacology... - AccessMyLibrary.com

FDA reviewing abuse-resistant pain drug  -  Dec 31, 2008
Embeda capsules contain an extended-release dose of morphine and a core of naltrexone, a drug that is used to combat addiction. King said that if the pill ... msnbc.com

… Tolerability of Long-Acting Injectable Naltrexone for Alcohol...  -  Apr 6, 2005
James C. Garbutt, MD; Henry R. Kranzler, MD; Stephanie S. O'Malley, PhD; David R. Gastfriend, MD; Helen M. Pettinati, PhD; Bernard L. Silverman, MD; ... Journal of American Medical Association - Journal of American Medical Association...

State Medicaid Programs Hinder Naltrexone Use  -  Nov 19, 2007
States that allow managed-care programs to limit prescriptions and access to pharmacy networks are hindering the use of naltrexone for treating alcohol ... JoinTogether.org

Low-Dose Naltrexone Therapy Improves Active Crohn's Disease  -  Jun 15, 2006
Correspondence: Jill P Smith, MD, Division of GI and Hepatology H-045, Department of Medicine, BMR C5800, Pennsylvania State University College of Medicine, ... Nature.com

Drug Helps Heroin Addicts Stay Clean  -  Jun 27, 2008
Their study of 126 detoxified heroin-dependent patients compared 24 weeks of treatment with naltrexone (a standard treatment), buprenorphine and placebo. ... Washington Post

Naltrexone weans alcoholics off the booze, slowly  -  Mar 15, 2005
By Graham Furness. Though he's only 38, this is the third time Chuck R is heading off to a rehab program for alcoholics. This time Chuck hopes to stay on ... National Review of Medicine

Injectable drug to help alcoholics stay sober hits the market.(Vivitro...  -  Jun 14, 2006
Vivitrol is based on an older pill called naltrexone that has been used for years to help alcoholics and opiate addicts. Alkermes re-engineered the drug so ... Free with registration - Boston Globe - AccessMyLibrary.com

Naltrexone may help Crohn's sufferers.  -  Feb 5, 2007
STATE COLLEGE, Pa., Feb. 5 (UPI) -- A US pilot study suggests a low dose of a pharmaceutical used to ease symptoms of drug addiction may also help sufferers ... Free with registration - UPI NewsTrack - AccessMyLibrary.com

Concern at side effects of heroin detox drug  -  Apr 21, 2008
THE use of implants of the rapid-detoxification drug, naltrexone, should be reviewed ... Of 12 hospital admissions of people with naltrexone implants, ... The Australian

Counselling and drugs 'work against alcohol'  -  May 3, 2006
The drug naltrexone reduced alcohol cravings in some patients studied but another drug, acamprosate, which also modifies brain receptors, proved ineffective ... Independent Online

Effect of behavioral therapy plus oral naltrexone examined in opioid-...  -  Apr 1, 2007
Among heroin-dependent patients, Behavioral Naltrexone Therapy (BNT) improved retention on oral naltrexone compared to a standard treatment control in a ... Free with registration - Brown University Digest of Addiction... - AccessMyLibrary.com

… Data on Its Proprietary Formulation of Naltrexone Sustained...  -  Oct 6, 2008
..."Contrave contains a sustained release formulation of naltrexone which we ... "The Phase 3 formulation of naltrexone in an oral sustained release form may ... RedOrbit

A new push to help alcoholics stay sober  -  Sep 27, 2005
Vivitrex is a reformulation of naltrexone that is administered by monthly injection ... Many insurers include the older treatments, Antabuse and naltrexone, ... Pay-Per-View - Newsday - ProQuest Archiver

Vivitrol: Monthly shot provides new option for alcoholism treatment  -  Jun 19, 2006
Vivitrol, a version of the drug naltrexone, is the first injectable drug to treat alcohol dependence. The Food and Drug Administration (FDA) approved ... cnn.com

… Results of Its Proprietary Naltrexone Sustained Release Formulation...  -  Sep 25, 2007
Orexigen has developed this proprietary SR formulation of naltrexone with the ... Naltrexone is a key component of the Company's lead product candidate for ... Free with registration - Business Wire - AccessMyLibrary.com

… Priority Review Granted for Vivitrex -Naltrexone Long-Acting...  -  May 27, 2005
Using the Medisorb technology, naltrexone is encapsulated in microspheres made of a biodegradable polymer that dissolve slowly and release drug at a ... RedOrbit

Monthly Naltrexone Drug Wins FDA Approval  -  Apr 18, 2006
Vivitrol, an injectable, once-monthly version of the alcoholism drug naltrexone, has been approved by the US Food and Drug Administration (FDA), ... JoinTogether.org

The pill that stops you binge drinking in just a few days  -  Aug 5, 2008
The drug, called naltrexone, has been shown to halve the amount people drink and cut ... Researchers at Yale University have been testing naltrexone as a ... Daily Mail

Naltrexone may help Crohn's sufferers  -  Feb 6, 2007
By : Science News Editor. STATE COLLEGE, Pa., Feb. 5 A US pilot study suggests a low dose of a pharmaceutical used to ease symptoms of drug addiction may ... earthtimes.org

Naltrexone (Systemic).  -  Jul 28, 2005
Naltrexone (nal-TREK-zone) is used to help narcotic addicts who have stopped taking narcotics to stay drug-free. It is also used to help alcoholics stay ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Alkermes: Positive results from Phase II study of naltrexone.  -  Dec 4, 2006
SAN FRANCISCO (MarketWatch) -- Alkermes Inc. on Monday reported positive results from a Phase II exploratory study of injectable extended-release naltrexone ... Free with registration - America's Intelligence Wire - AccessMyLibrary.com

FDA warns of reactions to alcohol dependence drug  -  Aug 13, 2008
Vivitrol, an extended-release version of the generic drug naltrexone marketed by Cephalon Inc (CEPH.O), was approved in 2006 to treat alcohol dependence in ... Reuters

Family history of alcoholism affects response to drug used to treat...  -  Sep 19, 2007
Perhaps consistent with its modest effects in COMBINE, naltrexone is not widely ... Yet, clinicians report that naltrexone may have significant benefits for ... eurekalert.org

New drug to help alcoholics becomes available in the US  -  Jan 11, 2005
Naltrexone, also called Revia, decreases the craving for alcohol, so if someone does drink, he ends up drinking less. "The brain really changes as you go ... Pay-Per-View - Star-Ledger - Factiva, from Dow Jones

Family History Of Alcoholism Affects Response To Drug Used To Treat …  -  Sep 24, 2007
24, 2007) — Naltrexone is one of four oral medications approved by the US Food ... Perhaps consistent with its modest effects in COMBINE, naltrexone is not ... sciencedaily.com

Naltrexone, Specialized Alcohol Counseling Effective Treatments for …  -  May 4, 2006
The medication naltrexone and up to 20 sessions of alcohol counseling by a behavioral specialist are equally effective treatments for alcohol dependence ... JoinTogether.org

The Evidence Gap Drug Rehabilitation or Revolving Door?  -  Dec 23, 2008
Among the therapies are prescription drugs like naltrexone, for alcohol dependence, and buprenorphine, for addiction to narcotics, which studies find can ... New York Times

… Tolerability of Long-Acting Injectable Naltrexone for Alcohol...  -  Apr 27, 2005
Incorrect data: In the Original Contribution entitled "Efficacy and Tolerability of Long-Acting Injectable Naltrexone for Alcohol Dependence: A Randomized ... Journal of American Medical Association - Journal of American Medical Association...

… men may respond differently to naltrexone.(Addiction Psychiatry) |...  -  Dec 1, 2007
Women and men may respond differently to naltrexone.(Addiction Psychiatry) ... find Clinical Psychiatry News articles. CHICAGO -- Naltrexone may have little ... Pay-Per-View - Clinical Psychiatry News - HighBeam Research

Naltrexone may increase the urge to drink  -  Jul 25, 2006
Naltrexone (NTX) is able to reduce drinking and craving among many alcoholics and heavy drinkers, but not all of them. Polymorphisms in the D4 dopamine ... News-Medical.net

Purdue, OxyContin Maker, Races Rivals to Deter Abuse  -  Apr 28, 2008
Alpharma and Elite are counting on the chemical naltrexone, which can ... Their painkillers include naltrexone encased in a protective coating that allows ... Bloomberg

FDA postpones decision on Alkermes application  -  Sep 22, 2005
Vivitrex is a monthly injectable version of naltrexone. It was scheduled for a Sept. 30 approval decision by the Food and Drug Administration, ... Boston Globe

Confirmation Of Effectiveness Of Naltrexone For Alcohol Dependence In...  -  May 13, 2008
Access to treatment for alcohol dependence (AD) in rural and remote areas is limited. This study evaluated the effectiveness of two pharmacotherapies for AD ... Medical News Today - Medical News Today (press release)

Naltrexone is effective for Alaska Natives and other Alaskans living...  -  May 11, 2008
Access to treatment for alcohol dependence (AD) in rural and remote areas is limited. This study evaluated the effectiveness of two pharmacotherapies for AD ... eurekalert.org

Valera submits IND for naltrexone implant.(Investigational New Drug …  -  Jul 17, 2006
Valera Pharmaceuticals submitted an Investigational New Drug Application (IND) to the Food and Drug Administration for its product VP0004, ... Free with registration - Alcoholism & Drug Abuse Weekly - AccessMyLibrary.com

Drug helps men reduce drinking in manufacturer-sponsored study .  -  Apr 7, 2005
A naltrexone pill was approved for alcoholism in 1994 but getting patients to ... For unknown reasons, injectable naltrexone was no bet ter than a placebo ... Reading Eagle - Google News Archive

Medications for alcohol dependence treatment: lessons from the...  -  Mar 1, 2007
Acamprosate and oral naltrexone have a substantial body of evidence supporting their use ... For example, a meta-analysis of oral naltrexone studies from ... Free with registration - Addiction Professional - AccessMyLibrary.com

Naltrexone and Counseling Reduce Alcohol Dependence  -  Sep 1, 2006
Synopsis: Behavioral interventions and at least two medications-naltrexone (Revia) and acamprosate (Campral)-are effective in the treatment of alcohol ... AAFP News Now

Naltrexone depot formulation increases adherence for alcoholism.(Menta...  -  Mar 1, 2005
NEW YORK -- An injectable depot formulation of naltrexone, now in phase III trials, may help overcome the adherence problems that have compromised the ... Free with registration - Family Practice News - AccessMyLibrary.com

Monthly injection form of naltrexone tested for alcoholism.(Rx)  -  Feb 15, 2005
NEW YORK -- An injectable depot formulation of naltrexone, now in phase III trials, may help overcome the adherence problems that have compromised the ... Free with registration - Internal Medicine News - AccessMyLibrary.com

Hooked on Tanning? Withdrawal Symptoms Back 'Tanning Addiction'  -  Mar 31, 2006
But infrequent tanners who take naltrexone don't get withdrawal symptoms. "In the beginning, we gave standard 50-milligram doses of naltrexone to frequent ... FOXNews

Rationale for combining acamprosate and naltrexone for treating...  -  Jul 1, 2005
ALCOHOL DEPENDENCE is a prevalent, chronic disorder with significant worldwide public health consequences. The development of safe and effective medications ... $4.95 - Journal of Studies on Alcohol - ECNext

Naltrexone therapy may control alcohol abuse over long term.(Addiction...  -  Jan 1, 2005
PARIS -- Long-term therapy with naltrexone can help keep alcohol-dependent patients on the wagon, Barbara J. Mason, Ph.D., said in a poster presentation at ... Free with registration - Clinical Psychiatry News - AccessMyLibrary.com

Naltrexone helps alcoholics control drinking  -  Apr 4, 2005
A little-known drug called naltrexone provides a “meaningful benefit� in helping alcoholics moderate their drinking, according to the latest review of ... News-Medical.net

Drug May Help Women Stop Smoking  -  Oct 10, 2006
Naltrexone helped reduce the craving for cigarettes and lessened the discomforts of ... "In this small study, naltrexone seems to have closed that gap." ... DG News

Naltrexone and CBT an effective combination: study.(Cognitive …  -  Aug 15, 2005
Patients treated for alcohol dependence with naltrexone did significantly better ... One group got 12 sessions over 12 weeks of CBT while taking naltrexone; ... Free with registration - Alcoholism & Drug Abuse Weekly - AccessMyLibrary.com

Article: WA: Naltrexone implants reduce heroin overdoses - WA study …  -  May 3, 2005
WA: Naltrexone implants reduce heroin overdoses - WA study shows ... find AAP General News (Australia) articles. AAP General News (Australia) 05-03-2005 WA: ... Pay-Per-View - AAP General News - HighBeam Research

Gene variant predicts medication response in patients with alcohol …  -  Feb 8, 2008
About 87 percent of patients with the variant who received naltrexone. ... An opioid antagonist, naltrexone blocks brain receptors for endogenous opioids, ... Science Centric

Alcoholism drug may curb problem gambling  -  Jun 16, 2008
Fifty-eight men and women took 50, 100 or 150 milligrams of naltrexone every day for 18 weeks. Forty percent of the 49 participants who took the drug and ... United Press International

Naltrexone Succeeds as Monthly For Alcohol Dependence  -  Apr 5, 2005
By Jeff Minerd,. CHAPEL HILL, NC-Monthly injections of the opioid antagonist naltrexone proved to be safe and effective for treating alcohol dependence, ... MedPage Today

Kadian not affected by alcohol  -  Feb 9, 2007
The subjects were given oral naltrexone hydrochloride 12 and two hours prior to treatment to counter the morphine effects, since morphine and alcohol can be ... United Press International

… Of Extended-Release And Oral Naltrexone Assists Substance Abuse …  -  May 7, 2007
Oral naltrexone and naltrexone for extended-release injectable suspension are the focus of a new comparative report recently released by the Substance Abuse ... emaxhealth.com

Alkermes treatment to be used on Mass. patients  -  Mar 12, 2007
...based outpatient substance dependence treatment provider, said Monday the naltrexone medication, known commercially as Vivitrol, will be used in combination ... Bizjournals.com

Doherty in Portugal for rehab  -  Nov 24, 2006
The 27-year-old Babyshambles frontman will have the drug naltrexone, which reduces the craving for heroin, implanted in his abdomen at the clinic at Oeiras, ... The Australian

… to Gather for Low Dose Naltrexone Conference. - PR Newswire | Hi  -  Sep 19, 2007
Advocates, Physicians Scheduled to Gather for Low Dose Naltrexone Conference. from PR Newswire. Highbeam Research – FREE Trial. Pay-Per-View - PR Newswire - HighBeam Research

Anti-drug jabs given at birth  -  Feb 2, 2007
Scientists have already developed a drug called naltrexone that eases heroin withdrawal symptoms. A cocaine vaccine called TA-CD has also been developed, ... The Sun

Relief without addiction .  -  Mar 18, 2007
Also being studied is a combination of naltrexone, a drug used to reduce alcohol craving, with oxycodone. The extra drug should tamp down oxycodone's ... Milwaukee Journal Sentinel - Google News Archive

Naltrexone effective for smoking cessation in women.(Gender Issues)  -  Jul 1, 2005
Naltrexone appears to have a positive cessation effect on female smokers when used in conjunction with nicotine replacement therapy and psychosocial therapy ... Free with registration - Brown University Digest of Addiction... - AccessMyLibrary.com

Combined Bupropion and Naltrexone Shows Promise for Obesity: …  -  Jun 12, 2006
By Jill Stein. WASHINGTON, DC -- June 12, 2006 -- The combination of bupropion and naltrexone demonstrates excellent weight-loss potential, according to ... DG News

Long-acting injectable naltrexone reduces heavy drinking.(Patient- …  -  Jul 1, 2005
Clinical question Is a long-acting injectable formulation of naltrexone effective in the management of alcohol dependence? ... Free with registration - JAAPA-Journal of the American Academy... - AccessMyLibrary.com

Quetiapine Combined With Naltrexone Does Not Enhance Efficacy for …  -  Oct 23, 2007
By Paula Moyer. VIENNA, AUSTRIA -- October 23, 2007 -- Patients do not receive any additional efficacy benefits when they receive quetiapine in addition to ... DG News

Implantable Naltrexone More Effective Than Oral Formulation in Heroin...  -  Sep 2, 2008
By Judith Moser, MD. BARCELONA, Spain -- September 2, 2008 -- Treatment retention and relapse prevention in patients with heroin addiction can be achieved ... DG News

Anti-Craving Drug, Naltrexone Helps Women Quit Smoking  -  Dec 5, 2006
A new study finds that the anti-craving drug, Naltrexone may lessen cessation-related weight gain and negative moods and women who are trying to quit ... MedIndia

Monthly Injections of Naltrexone Show Continued Benefit in Treating...  -  Jun 1, 2005
June 1, 2005 (Atlanta) — Patients with alcohol dependence who continue taking naltrexone (Vivitrex) for a year or more continue to benefit from treatment, ... Medscape

… : Rationale for combining acamprosate and naltrexone for treating...  -  Jul 1, 2005
Rationale for combining acamprosate and naltrexone for treating alcohol dependence *. ... find Journal of Studies on Alcohol articles. Pay-Per-View - Journal of Studies on Alcohol - HighBeam Research

… Entertainers to Gather for Low Dose Naltrexone Conference. - PR...  -  Mar 13, 2006
Advocates, Physicians and Entertainers to Gather for Low Dose Naltrexone Conference. from PR Newswire. Highbeam Research – FREE Trial. Pay-Per-View - PR Newswire - HighBeam Research

… Brain Pet Scans to Measure Optimal Naltrexone Dosing for Treating ...  -  Sep 13, 2006
Naltrexone is an opioid receptor antagonist used in the management of alcohol and ... Dr. Tollefson continued: "Although naltrexone has been available ... RedOrbit

Family First backs forced treatment  -  Oct 22, 2006
The policy also includes boosting funding for residential rehabilitation programs, more research into alternative therapies like Naltrexone implants and a ... NEWS.com.au

Injectable naltrexone shown effective in reducing heavy drinking.  -  Apr 11, 2005
A new injectable form of naltrexone may offer a promising adjunct to the treatment of alcoholism, according to research results published in the April 6 ... Free with registration - Alcoholism & Drug Abuse Weekly - AccessMyLibrary.com

Naltrexone-based therapy best for alcoholic patients.(Clinical report)  -  Jun 1, 2006
SAN DIEGO -- A study that is perhaps the most important conducted on alcohol dependence treatment in recent years has found that the use of the opiate ... Free with registration - Internal Medicine News - AccessMyLibrary.com

Naltrexone implants: inquiry needed  -  Apr 29, 2008
...by Dr Norman Swan. A disturbing report of injuries linked to the unapproved, unregulated use of naltrexone implants has prompted calls for an independent ... ABC Regional Online - ABC Regional Online

Treat first, pay later strains naltrexone clinic  -  May 19, 2007
The Subiaco-based Fresh Start Recovery Naltrexone Clinic has had a boost with a 14-seat bus being funded by Lotterywest. Dr George O'Neil said the bus would ... postnewspapers.com.au

Brand Names/Synonyms:
Naltrexone is also known by the following brand names and/or synonymsCCRIS 3506; Celupan; HSDB 6750; N-Cyclopropylmethylnoroxymorphone; Naltrexona [Inn-Spanish]; Naltrexone; Naltrexone Hcl; Naltrexone [Usan:Ban:Inn]; Naltrexonum [Inn-Latin]; Revia; UM-792; Vivitrex

Drug Category:
Naltrexone is categorized under the following by the FDA: Anti-craving Agents; Depressants; Alcohol Antagonists; Opiate Antagonists; ATC:N07BB04

Dosage Forms:
TABLET

Absorption:
Not Available

Interactions:
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Chemical IUPAC Name:
Not Available





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