Nicardipine

This page contains recent news articles, when available, and an overview of Nicardipine but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Nicardipine
(when available)

Pharmacology and use:
Nicardipine, a dihydropyridine calcium-channel blocker, is used alone or with an angiotensin-converting enzyme inhibitor, to treat hypertension, chronic stable angina pectoris, and Prinzmetal's variant angina. Nicardipine is similar to other peripheral vasodilators. Nicardipine inhibits the influx of extra cellular calcium across the myocardial and vascular smooth muscle cell membranes possibly by deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum. The decrease in intracellular calcium inhibits the contractile processes of the myocardial smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload. Used for the management of patients with chronic stable angina

Mechanism Of Action:
By deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum, Nicardipine inhibits the influx of extracellular calcium across the myocardial and vascular smooth muscle cell membranes The decrease in intracellular calcium inhibits the contractile processes of the myocardial smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload.

News Articles on Nicardipine

MDCO Recalls Cleviprex Lots  -  ‎Dec 18, 2009‎
We believe sales are being impacted by the presence of a generic version of nicardipine launched by Teva (TEVA - Snapshot Report) in the market. ... Zacks.com

EKR Therapeutics Receives Notice of Patent Allowance for Ready-to-Use Cardene ...  -  ‎Oct 28, 2009‎
About Cardene IV Formulated with the anti-hypertensive agent nicardipine hydrochloride and originally approved by FDA in 1992, Cardene® IV is a calcium ion ... Reuters

Experimental Drug Controls Cardiac Patients' Blood Pressure  -  Mar 27, 2007
...(an intravenous dihydropyridine calcium channel blocker) to each of the three standard treatments (nitroglycerin, sodium nitroprusside or nicardipine). ... Washington Post

Teva Introduces Nicardipine HCl Injection in the United States;  -  Sep 22, 2008
JERUSALEM--(BUSINESS WIRE)--September 22, 2008 Teva Pharmaceutical Industries Ltd. (Nasdaq: TEVA) announced today the introduction of Nicardipine ... Bloomberg

The acquisition of Merck unit would triple Mylan's size  -  Sep 28, 2007
The blood pressure drugs to be divested include acebutolol hydrochloride capsules, guanfacine hydrochloride tablets, nicardipine hydrochloride capsules and ... Pittsburgh Post-Gazette - Pittsburgh Post Gazette

Nicardipine Helps Restore Cerebral Oxygenation in Hypertensive Crisis...  -  Feb 27, 2006
By Paula Moyer. ORLANDO, FL -- February 27, 2006 -- Intravenous nicardipine is an effective way of restoring cerebral oxygenation without deleterious ... DG News

… Shipments of Premixed Double Concentration Cardene® IV (nicardipine...  -  Dec 10, 2008
EKR's product offerings of Cardene IV RTU bags also include single (1X) concentration preparations of 200 ml bags containing 20 mg of nicardipine ... International Business Times

Electroconvulsive Therapy; Nicardipine before ECT stimulus controlled...  -  Mar 29, 2005
2005 MAR 29 - (NewsRx.com) -- A recent report described the results of a dose-ranging study on the use of nicardipine for electroconvulsive therapy. ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

Electroconvulsive Therapy; Nicardipine before ECT stimulus controlled...  -  Mar 28, 2005
2005 MAR 28 - (NewsRx.com) -- A recent report described the results of a dose-ranging study on the use of nicardipine for electroconvulsive therapy. ... Pay-Per-View - Cardiovascular Week - Factiva, from Dow Jones

Safety and Feasibility of Intra-Arterial Nicardipine for the Treatment...  -  Jun 1, 2008
JG Tejada a , RA Taylor a , MS Ugurel a , M. Hayakawa a , SK Lee a and JC Chaloupka a. Address correspondence to Juan G. Tejada, MD, Department of Radiology ... AJNR (subscription)

Nicardipine safe for cutting BP in hypertensive emergency.( …  -  Jun 1, 2005
Nicardipine safe for cutting BP in hypertensive emergency.(Cardiovascular Medicine)(blood pressure) ... find Internal Medicine News articles. PHOENIX, ARIZ. Pay-Per-View - Internal Medicine News - HighBeam Research

Thrombolytics Safe in Acute Stroke Despite Aggressive Blood Pressure ...  -  Sep 10, 2008
The rest received more aggressive treatment with nicardipine, given as a continuous infusion starting at 5 mg per hour and increased as needed to a maximum ... MedPage Today

Nicardipine seen safe for use in high-blood-pressure crises.( …  -  Jul 1, 2005
Nicardipine seen safe for use in high-blood-pressure crises.(Cardiovascular Medicine) ... find Family Practice News articles. PHOENIX, ARIZ. Pay-Per-View - Family Practice News - HighBeam Research

Clevidipine During Heart Surgery Improves Blood Pressure Control, …  -  Apr 1, 2007
The third study found no significant difference in blood pressure control between clevidipine and nicardipine (5.27 vs. 5.67 AUC). The safety outcomes were ... Medical News Today - Medical News Today (press release)

Pivotal Phase III Findings With Investigational Drug Cleviprex(TM) ( …  -  Mar 27, 2007
127.87 mm Hg x min/h, p = 0.0068), nicardipine (76.5 vs. ... Nicardipine is selective for arteries, but because it has a slower onset and longer duration of ... $4.95 - PR Newswire - ECNext

Competitors by Product Report  -  Aug 2, 2008
Par Pharmaceutical Companies, Inc. (PRX) Products:. Amlodipine Besylate; Nicardipine HCl; Verapamil Hydrochloride. Penwest Pharmaceuticals (PPCO) Products: ... $75.00 - Revere Reports - Revere

Competitors by Product Report  -  Aug 2, 2008
Par Pharmaceutical Companies, Inc. (PRX) Products:. Amlodipine Besylate; Nicardipine HCl; Verapamil Hydrochloride. Penwest Pharmaceuticals (PPCO) Products: ... $75.00 - Revere - Alacra Store

Calcium Channel Blocking Agents (Systemic).  -  Aug 1, 2006
...flushing and feeling of warmth (more common with nicardipine and nifedipine) headache (more common with amlodipine, felodipine, isradipine, and nifedipine) ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Pivotal Phase III Findings With Investigational Drug Cleviprex(TM) ( …  -  Mar 29, 2007
127.87 mm Hg x min/h, p = 0.0068), nicardipine (76.5 vs. ... Nicardipine is selective for arteries, but because it has a slower onset and longer duration of ... Medical News Today - Medical News Today (press release)

Calcium Channel Blocking Agents (Systemic).(Drug overview)  -  May 1, 2006
...flushing and feeling of warmth (more common with nicardipine and nifedipine) headache (more common with amlodipine, felodipine, isradipine, and nifedipine) ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Treatment shown to aid victims of strokes  -  Jun 21, 2006
The single-center study, conducted at the UMDNJ-New Jersey Medical School in Newark, showed that the drug - nicardipine hydrochloride - safely reduced blood ... Pay-Per-View - Star-Ledger - Factiva, from Dow Jones

Cardiologists Find Drug Effective In Reversing Deadly Problem In …  -  Oct 17, 2006
The researchers report that nicardipine therapy was well tolerated. No patient experienced low blood pressure (hypotension), heart block or required a ... sciencedaily.com

EKR Therapeutics Receives Approval for Ready-to-Use Intravenous  -  Aug 1, 2008
The 200 ml RTU bags contain 20 mg of the anti-hypertensive agent nicardipine hydrochloride (0.1 mg/ml) in either dextrose or sodium chloride. ... Bloomberg

Controlling Perioperative Hypertension With Cleviprex Reduces Risk of...  -  Jun 20, 2008
No patients received nicardipine prior to cardiac surgery; therefore, they were excluded from this ... Cleviprex was equally as effective as nicardipine. ... RedOrbit

Competitors by Product Report  -  Dec 16, 2006
Amlodipine Besylate; Diltiazem Hydrochloride; Nicardipine Hydrochloride; Verapamil Hydrochloride/Verapamil Hydrochloride ER ... $75.00 - Revere Reports - Revere

EKR Therapeutics Broadens Its Ready-to-Use Cardene(R) IV Product …  -  Nov 11, 2008
These patented 200 ml ready-to-use (RTU) intravenous bags contain 40 mg of the calcium channel blocker nicardipine hydrochloride (0.2 mg/ml) in either ... Genetic Engineering News - Genetic Engineering News (press release)

Grapefruit juice--drug interactions: update on the most common and …  -  Feb 1, 2005
Examples include amlodipine instead of nicardipine, pravastatin instead of atorvastatin, and alprazolam instead of midazolam. Drugs may also be administered ... $4.95 - Consultant - ECNext

National Institutes of Health, US Researchers from National Institutes...  -  Jan 8, 2007
..."Both nicardipine and nifedipine stimulated the ATPase activity of ABCG2, and the nifedipine-stimulated activity was inhibited by fumitremorgin C, ... Pay-Per-View - Health & Medicine Week - Factiva, from Dow Jones

National Institutes of Health, US Scientists from National Institutes...  -  Dec 11, 2006
..."Both nicardipine and nifedipine stimulated the ATPase activity of ABCG2, and the nifedipine-stimulated activity was inhibited by fumitremorgin C, ... Pay-Per-View - Health & Medicine Week - Factiva, from Dow Jones

The Medicines Company Reports Positive Results From Antihypertensive ...  -  Oct 6, 2008
Cleviprex was equivalent to nicardipine in maintaining BP within the initial broad range, however, when the BP range was narrowed, Cleviprex was also ... RedOrbit

New Publication Shows CleviprexTM Provides More Precise Blood …  -  Oct 3, 2008
Cleviprex was equivalent to nicardipine in maintaining BP within the initial broad range, however, when the BP range was narrowed, Cleviprex was also ... FierceBiotech

PDL's Buyout Of ESP Pharma: $475M For Drugs, Sales Team  -  Jan 26, 2005
ESP, of Edison, NJ, brings to the table Cardene IV (nicardipine hydrochloride), for short-term treatment of hypertension when oral therapy is not feasible. ... BioWorld Online - BioWorld Online

Improved Perioperative Blood Pressure Control Associated with Reduced...  -  Oct 15, 2007
Nicardipine is selective for arteries, but because it has a slower onset and longer duration of action, and accumulates over time in the body, ... Free with registration - Business Wire - AccessMyLibrary.com

DNA hydrogels: Fishy fluorescence  -  Dec 17, 2008
They found that when the hydrogel was loaded with nicardipine ... As the hydrogel slowly released nicardipine hydrochloride in a slightly acidic environment ... Nature.com

Protein Design to acquire ESP Pharma.  -  Jan 1, 2005
Cardene IV (nicardipine hydrochloride injection). ... Cardene is a patent -protected intravenous preparation of nicardipine, a dihydropyridine calcium ... Free with registration - BIOTECH Patent News - AccessMyLibrary.com

Nouveau progrès cardiologique dans le traitement par angioplastie des...  -  Oct 12, 2006
Les cardiologues de l'université Thomas Jefferson ont trouvé qu'un médicament, un inhibiteur calcique déjà utilisé en cardiologie, la nicardipine (RYDENE, ... InformationHospitaliere.com

Calcium channel blocker ingestion: an evidence-based consensus …  -  Dec 1, 2005
At doses used clinically, nifedipine and other dihydropyridines (amlodipine, felodipine, isradipine, nicardipine, and nimodipine) are relatively selective ... Free with registration - Clinical Toxicology - AccessMyLibrary.com

Phenylephrine to increase blood flow in the radial artery used as a …  -  May 15, 2007
RESULTS: Mean radial artery flow increased similarly in all groups: normal saline, 40% ± 25%; nicardipine, 37% ± 27%; nitroglycerin, 48% ± 36% (P = .533). ... The Journal of Thoracic and Cardiovascul...

14 News, The Tri-State's News and Weather Leader-Drug Reverses …  -  Oct 11, 2006
WEDNESDAY, Oct. 11 (HealthDay News) -- The drug nicardipine is effective in reversing a potentially deadly problem that occurs in some patients who have ... WFIE-TV

Edema Associated With Infarct . . . Or Something Else?  -  Jan 1, 2007
Commonly used agents include intravenous labetalol and nicardipine. Intravenous nicardipine in particular has an advantage of being easily titrated, ... Psychiatric Times

SCCM: Clevidipine Seems Safe and Effective in BP Control  -  Feb 20, 2007
A better comparison, he said, would be intravenous nicardipine (Cardene IV), ... "We don't know yet if this drug is going to be better than nicardipine," he ... MedPage Today

PDL to Acquire ESP Pharma, Inc.  -  Jan 25, 2005
Cardene IV (nicardipine hydrochloride injection). ... Cardene is a patent-protected intravenous preparation of nicardipine, a dihydropyridine calcium ... $4.95 - PR Newswire - ECNext

Blood pressure control with Clevidipine  -  Mar 30, 2007
The third study found no significant difference in blood pressure control between clevidipine and nicardipine (5.27 vs. 5.67 AUC). The safety outcomes were ... News-Medical.net

Mergers & Acquisitions; Medical laboratory acquires pharmaceutical …  -  Feb 21, 2005
Cardene IV (nicardipine hydrochloride injection). ... Cardene is a patent-protected intravenous preparation of nicardipine, a dihydropyridine calcium ... Pay-Per-View - Clinical Oncology Week - Factiva, from Dow Jones

Competitors by Product Report  -  Sep 30, 2006
Amlodipine Besylate; Diltiazem Hydrochloride; Nicardipine Hydrochloride; Verapamil Hydrochloride/Verapamil Hydrochloride ER ... $75.00 - Revere Reports - Revere

Amneal laying foundation for growth.(Generic Drugs)(Amneal …  -  Oct 22, 2007
Those products are acebutolol hydrochloride capsules, flecainide acetate tablets, guanfacine hydrochloride tablets, nicardipine hydrochloride capsules and ... Free with registration - Chain Drug Review - AccessMyLibrary.com

High blood pressure after stroke should not necessarily rule out use...  -  Sep 8, 2008
This included 24 (48 percent) who received the medication nicardipine, either alone or in combination with the drug labetalol. ... eurekalert.org

Factiva Search  -  Mar 28, 2005
Electroconvulsive Therapy; Nicardipine before ECT stimulus controlled hemodynamic response. 28 March, 2005 Health & Medicine Week ... Pay-Per-View - Health & Medicine Week - Factiva, from Dow Jones

What is the evaluation and treatment strategy for Raynaud's phenomenon...  -  Jun 1, 2005
Nicardipine showed a trend towards reduced symptoms in 1 trial with only 15 patients. (8) Another randomized trial comparing sustained-release nifedipine to ... $4.95 - Journal of Family Practice - ECNext

High Blood Pressure Should Not Rule Out Clot-Busting Stroke Treatment  -  Sep 5, 2008
This included 24 (48 percent) who received the medication nicardipine, either alone or in combination with the drug labetalol. ... newswise.com

Federal Register 2007 - 72 FR 57579 Mylan Laboratories and E. Merck …  -  Oct 10, 2007
...hydrochloride tablets; (4) nicardipine hydrochloride capsules; and (5) sotalol hydrochloride AF tablets to Amneal Pharmaceuticals LLC ("Amneal"). ... Pay-Per-View - Federal Register 2007 - Loislaw

Physiology; Coronary smooth muscle contraction studied, role of Mg2+ ...  -  Feb 21, 2005
Furthermore, in pressurized arteries, the ET-1-induced contraction was also inhibited by La3+ and streptomycin, but not by nicardipine. U-73122, a selective ... Pay-Per-View - Cardiovascular Week - Factiva, from Dow Jones

Anaphylactic Shock; Pathophysiology of anaphylaxis during anesthesia ...  -  Aug 16, 2005
..."The ovalbumin group but not the nicardipine group displayed decreased skeletal muscle blood flow (from 45±6.2 mL/100 g/min to 24.3±5 mL/100 g/min; ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

Physiology; Coronary smooth muscle contraction studied, role of Mg2+ ...  -  Feb 27, 2005
Furthermore, in pressurized arteries, the ET-1-induced contraction was also inhibited by La3+ and streptomycin, but not by nicardipine. U-73122, a selective ... Pay-Per-View - Heart Disease Weekly - Factiva, from Dow Jones

Competitors by Product Report  -  Mar 29, 2008
Par Pharmaceutical Companies, Inc. (PRX) Products:. Amlodipine Besylate; Nicardipine HCl; Verapamil Hydrochloride. Penwest Pharmaceuticals (PPCO) Products: ... $75.00 - Revere Reports - Revere

Force of blood  -  Nov 12, 2006
Included in this group are drugs such as amlodipine, diltiazem HCl, felodipine, isradipine, lercanidipine HCl, lacidipine, nifedipine, nicardipine HCL, ... Malaysia Star

US FTC OKs Mylan buy of German Merck generics unit  -  Sep 27, 2007
The drugs include four hypertension treatments: acebutolol hydrochloride, sotalol hydrochloride AF, guanfacine hydrochloride and nicardipine hydrochloride. ... Reuters

FDA OKs Medicines Co.'s Cleviprex  -  Aug 4, 2008
Amin says the approval of Teva's (TEVA Quote) nicardipine, which is similar to Cardene, also could add pricing pressure. Thus the analyst sees Cleviprex's ... TheStreet.com - TheStreet.com (subscription)

Your guide to hypertension  -  Jul 9, 2006
Calcium-channel blockers: such as Amlodipine, Nisoldipine, Diltiazem, Verapamil, Felodipine, Isradipine, Lacidipine, Nicardipine and Nifedipine. ... Daily Mail

Coffee, fish oil may combat Alzheimer's  -  Nov 8, 2007
The three medications include Coreg, now sold in generic form as carvedilol, and the Roche drugs, sold generically as propranolol and nicardipine. ... Boston Globe

Blood pressure drug may help Alzheimer's  -  Oct 26, 2007
The other six drugs with possibly beneficial cognitive results included Propranolol HCI, Carvedilol, Losartan, Nicardipine HCI, Amiloride HCI and ... United Press International

New Abbott Aluvia® Tablet for Treatment of HIV Available in South...  -  Jun 2, 2008
...nicardipine) and medicines used to correct heart rhythm (eg bepridil, systemic lidocaine, quinidine), antifungals, (eg ketoconazole, itraconazole), ... AllAfrica.com

Poor Perioperative Blood Pressure Control Linked to 30-Day  -  Oct 21, 2008
...open-label trials comparing Cleviprexâ„¢ (clevidipine butyrate) injectable emulsion to nitroglycerin, sodium nitroprusside or nicardipine. ... Bloomberg

Figure 2 : Small-molecule aggregates inhibit amyloid polymerization :...  -  Jan 27, 2008
...(b) The known chemical aggregate-forming molecules nicardipine, DAPH and baicalein block infection to varying degrees. (c) Infection is blocked in a ... Nature.com

Blood pressure drugs may help Alzheimer's  -  Dec 18, 2007
Aside from Valsartan, other agents with beneficial results included Propranolol HCI, Carvedilol, Losartan, Nicardipine HCI, Amiloride HCI and Hydralazine ... Daily Mail

Market Report / Banks, real estate retreat  -  Sep 25, 2008
Among other things the company has launched nicardipine injections, to treat chronic angina and high blood pressure. Brand sales of the original drug were ... Ha'aretz

Chronic Eczematous Eruptions of the Elderly Are Associated with...  -  Jan 24, 2007
Drugs involved were nicardipine (n=6), amlodipine (n=2), and felodipine (n=1). Drugs were taken for a mean time of 5.74.1 months before the onset of ... Nature.com

MEDS BETTER THAN GRAPEFRUIT  -  Mar 25, 2007
Atorvastatin (Lipitor), lovastatin (Mevacor), simvastatin (Zocor), diltiazem (Cardizem and others), felodipine (Plendil), nicardipine (Cardene), ... Pay-Per-View - South Florida Sun - Sentinel - ProQuest Archiver

Article: Fish oil, caffeine may thwart Alzheimer's - Deseret News...  -  Nov 8, 2007
The three medications include Coreg, now sold in generic form as carvedilol, and the Roche drugs, sold generically as propranolol and nicardipine. ... Pay-Per-View - Deseret News - HighBeam Research

The Medicines Company Completes Clevidipine Phase III Safety Trials …  -  Sep 11, 2006
The three ECLIPSE studies compared clevidipine to active comparators; nitroglycerin, sodium nitroprusside, and nicardipine. The Company expects to review ... Free with registration - Business Wire - AccessMyLibrary.com

Comparison between valsartan and valsartan plus cilnidipine in type...  -  May 17, 2006
At the time of screening, CCBs were withdrawn from 27 patients (amlodipine 6, benidipine 4, efonidipine 1, nicardipine 2, nifedipine 7, nilvadipine 2, ... Nature.com

"CCB 복용, ìž?몽주스 주ì?˜í•˜ì„¸ìš”"  -  Dec 23, 2008
...� 외� 암로디핀(amlodipine),니페디핀(nifedipine), 니카르디핀(nicardipine) 등 ' 칼슘채� 차단제'는 �몽주스와 함께 먹으면 약 �성� 나타날 수 있으므로 주� ... 아�비타임즈

“고혈압약 드시는 ë¶„, ì?´ëŸ° ì?Œì‹?ì?€ 피하세요â€?  -  Dec 2, 2008
...� 외� 암로디핀(amlodipine),니페디핀(nifedipine), 니카르디핀(nicardipine) 등 ' 칼슘채� 차단제'는 �몽주스와 함께 먹으면 약 �성� 나타날 수 있으므로 주� ... 아�비타임즈

EKR Therapeutics and PDL BioPharma Sign Asset Purchase Agreement …  -  Feb 4, 2008
...to PDL's cardiovascular products, consisting of Cardene(R) IV (nicardipine hydrochloride), Cardene SR(R) and new formulations of Cardene in development, ... Lifescience-online

Abbott Submits EU and US Regulatory Filings for New Lower-Strength …  -  Jul 20, 2007
...(eg, felodipine, nifedipine, nicardipine) and medicines used to correct heart rhythm (eg, bepridil, systemic lidocaine, quinidine), antifungals, (eg, ... Free with registration - PR Newswire - AccessMyLibrary.com

Protein Design Labs Becomes PDL BioPharma.  -  Jan 9, 2006
The company now markets Cardene(R) IV (nicardipine hydrochloride) for short-term treatment of hypertension when oral therapy is not feasible or desirable, ... Free with registration - PR Newswire - AccessMyLibrary.com

Hypertension drugs may prevent Alzheimer's Disease  -  Oct 28, 2007
Other anti-hypertension drugs which also offered benefits included Propranolol HCI, Carvedilol, Losartan, Nicardipine HCI, Amiloride HCI and Hydralazine HCI ... News-Medical.net

The Medicines Company Voluntarily Suspends Enrollment In Clevelox-- …  -  Mar 28, 2005
The comparative treatments are nitroglycerin, sodium nitroprusside and nicardipine. The Medicines Company meets the demands of the world's most advanced ... Free with registration - Business Wire - AccessMyLibrary.com

The Medicines Company's Cleviprex(TM) (Clevidipine) Phase III Safety ...  -  Jan 8, 2007
The three ECLIPSE studies compared Cleviprex to active comparators: nitroglycerin, sodium nitroprusside and nicardipine. For the primary safety objectives, ... Genetic Engineering News - Genetic Engineering News (press release)

PDL BioPharma Completes Sale of Cardiovascular Products to EKR …  -  Mar 10, 2008
...consisting of Cardene® IV (nicardipine hydrochloride), Cardene SR® and new formulations of Cardene in development, as well as Retavase® (reteplase) and ... Lifescience-online

Cleviprex(TM) Demonstrated Rapid, Precise Blood Pressure Control in …  -  Feb 5, 2008
...open-label studies comparing Cleviprex to current intravenous antihypertensive agents: nitroglycerin, sodium nitroprusside or nicardipine. ... Free with registration - Business Wire - AccessMyLibrary.com

Medicines Co. Halts Drug Trial Over Irregular Heartbeat Risk  -  Mar 29, 2005
...in people taking nitroglycerin, sodium nitroprusside or nicardipine, according to an interim analysis of approximately half of the study's participants. ... RedOrbit

The Medicines Company Resumes Clevidipine Phase III Program; Phase …  -  Oct 19, 2005
The comparative treatments are nitroglycerin, sodium nitroprusside and nicardipine. The Medicines Company (NASDAQ: MDCO) meets the demands of the world's ... RedOrbit

Speak with other shareholders about: (NASDAQ: ACAP), (OTCBB: NILR), …  -  Mar 10, 2008
...consisting of Cardene IV (nicardipine hydrochloride), Cardene SR and new formulations of Cardene in development, as well as Retavase (reteplase) and the ... Free with registration - M2 Presswire - AccessMyLibrary.com

The Medicines Company Products Angiomax(R) (Bivalirudin) and …  -  Mar 15, 2007
With Nitroglycerin, Sodium Nitroprusside, or Nicardipine in the Treatment of Perioperative Hypertension: Results of the Three Randomized ECLIPSE Trials. ... RedOrbit

Roche Gives Up Daclizumab; PDL Seeking Asthma Partner  -  Nov 27, 2006
PDL, of Freemont, Calif., also gets income from marketed products such as the calcium channel blocker Cardene (nicardipine hydrochloride), ... BioWorld Online - BioWorld Online

EKR Therapeutics Appoints Co-Founder Richard DeSimone as COO  -  Mar 27, 2008
The Company's growing portfolio of specialty acute-care products includes Cardene(R) IV (nicardipine hydrochloride), Cardene SR(R), Retavase(R) (reteplase ... Genetic Engineering News - Genetic Engineering News (press release)

Ugandan Children Are Among the First to Receive Abbott's Lower- …  -  Dec 1, 2007
...(eg, felodipine, nifedipine, nicardipine) and medicines used to correct heart rhythm (eg, bepridil, systemic lidocaine, quinidine), antifungals, (eg, ... Free with registration - PR Newswire - AccessMyLibrary.com

Early detection and management of cerebral aneurysms: cerebral …  -  Nov 1, 2006
If necessary, the patient will be given IV antihypertensive agents such as labetalol (Normodyne, Trandate) and nicardipine (Cardene). ... Free with registration - Patient Care for the Nurse Practitioner - AccessMyLibrary.com

How to take Zafirlukast from Consumer Reports Health.  -  Jan 1, 2007
...felodipine (Plendil), isradipine (Dynacirc), nicardipine (Cardene), nifedipine (Adalat, Procardia, others), nimodipine (Nimotop), nisoldipine (Sular), ... consumerreports.org

Nursing issues in caring for children with moyamoya vasculopathy and ...  -  Feb 1, 2007
Calcium channel blockers such as nicardipine may decrease vasoconstriction and help prevent recurrent stroke (Hosain, Hughes, Forem, Wisoff, & Fish, 1994). ... Free with registration - Journal of Neuroscience Nursing - AccessMyLibrary.com

TMC's Cleviprex impresses in ECLIPSE trials.(The Medicines Co.)( …  -  Apr 9, 2007
Investigators compared the drug with nitroglycerin, sodium nitroprusside or nicardipine by taking baseline readings prior to surgery, and then allowing each ... Free with registration - Pharma Marketletter - AccessMyLibrary.com

New Abbott Aluvia(R) Tablet for Treatment of HIV Available in South …  -  Mar 6, 2008
...(eg, felodipine, nifedipine, nicardipine) and medicines used to correct heart rhythm (eg, bepridil, systemic lidocaine, quinidine), antifungals, (eg, ... ITNews

Ginkgo.(Drug overview)  -  Aug 1, 2006
...enhances gene expression of hepatic cytochrome P-450 and attenuates the hypotensive effect of nicardipine in rats. Life Sci 2002; 70(23): 2783-2792. ... Free with registration - AltCareDex Alternative Medicines - AccessMyLibrary.com

Actelion to discuss detailed analysis of CONSCIOUS-1 at CNS - …  -  Oct 9, 2006
And we excluded patients who had prophylactic intravenous nimodipine or nicardipine; and oral nimodipine was permitted. The next slide shows the patient ... Free with registration - America's Intelligence Wire - AccessMyLibrary.com

Medicines that may cause arm or leg problems  -  Jul 28, 2008
Blood pressure medicines, such as nifedipine (Procardia), amlodipine (Norvasc), or nicardipine (Cardene). Cholesterol-lowering medicines, such as ... MSN Health & Fitness

Mylan, Merck KGaA Must Divest Drug Assets to Complete Acquisition  -  Oct 8, 2007
...acetate) tablets, generic Tenex (guanfacine HCl) tablets, generic Cardene (nicardipine HCl) capsules and generic Betapace AF (sotalol HCl) tablets. ... FDA news - FDA news (subscription)

Treatment for Digital Ulcers Due to Raynaud's Phenomenon  -  Nov 17, 2005
In addition, nicardipine was not effective in one study and only minimally different from placebo in another. In addition to calcium channel blockers, ... Medscape

Delavirdine (Systemic).  -  Feb 1, 2006
Norvasc) or Diltiazem (eg, Cardizem) or Felodipine (eg, Plendil) or Isradipine (eg, DynaCirc) or Nicardipine (eg, Cardene) or Nifedipine (eg, ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Hemorrhagic Stroke Guidelines Issued  -  Jun 20, 2007
The Antihypertensive Treatment in Acute Cerebral Hemorrhage (ATACH) pilot study, begun in 2005, will evaluate the outcomes of 60 patients given nicardipine ... Journal of American Medical Association - Journal of American Medical Association...

Ginkgo.(Health Aspects)  -  May 1, 2006
...enhances gene expression of hepatic cytochrome P-450 and attenuates the hypotensive effect of nicardipine in rats. Life Sci 2002; 70(23): 2783-2792. ... Free with registration - AltCareDex Alternative Medicines - AccessMyLibrary.com

PDL BioPharma Business Update - Part 2.  -  May 5, 2006
And then you can also use Nicardipine, Cardene, in IV drip. Starting dosage uses 5 milligrams per hour, you can titrate by 2.5 milligrams every hour, ... Free with registration - America's Intelligence Wire - AccessMyLibrary.com

Brand Names/Synonyms:
Nicardipine is also known by the following brand names and/or synonymsCardene; Cardene Sr; Nicardipine; Nicardipine Hcl; Nicardipino [Inn-Spanish]; Nicardipinum [Inn-Latin]; YC-93

Drug Category:
Nicardipine is categorized under the following by the FDA: Antiarrhythmic Agents; Vasodilator Agents; Antihypertensive Agents; Dihydropyridines; ATC:C08CA04

Dosage Forms:
CAPSULE

Absorption:
While nicardipine is completely absorbed, it is subject to saturable first pass metabolism and the systemic bioavailability is about 35% following a 30 mg oral dose at steady state.

Interactions:
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Chemical IUPAC Name:
methyl2-(benzyl-methyl-amino)ethyl2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate





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