Nicotine Polacrilex

This page contains recent news articles, when available, and an overview of Nicotine Polacrilex but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Nicotine Polacrilex
(when available)

Pharmacology and use:
Nicotine, the primary alkaloid in tobacco products binds stereo-selectively to nicotinic-cholinergic receptors on autonomic ganglia, the adrenal medulla, neuromuscular junctions and in the brain. Nicotine exerts two effects, a stimulant effect exerted at the locus ceruleus and a reward effect in the limbic system. Itranvenous administration of nicotine causes release of acetylcholine, norepinephrine, dopamine, serotonine, vasopressin, beta-endorphin and ACTH. Nicotine is a highly addictive substance. Nicotine also induces peripheral vasoconstriction, tachycardia and elevated blood pressure. Nicotine inhalers and patches are used to treat smoking withdrawl syndrome. Nicotine is classified as a stimulant of autonomic ganglia. For the relief of nicotine withdrawal symptoms and as an aid to smoking cessation

Mechanism Of Action:
Nicotine binds to the nicotinic acetylcholine receptor. Stimulation of nicotinic receptors leads to a variety of cholinergic and adrenergic effects; tachycardia or bradycardia mediated by either stimulation or interference with sympathetic or parasympathetic pathways, stimulation of receptors in the carotic and aortic bodies, release of epinephrine from the adrenal medulla, and stimulation of the chemoreceptor-trigger zone.

News Articles on Nicotine

Coated nicotine polacrilex gum USP.(OTC)(Brief article)  -  Jul 24, 2006
Perrigo Co., Allegan, Mich., (800) 719-9260, is introducing mint-flavored coated nicotine polacrilex gum USP, 2 mg and 4 mg. The product, expected to be ... Free with registration - Drug Topics - AccessMyLibrary.com

Watson Pharmaceuticals Receives FDA Approval for Mint Coated  -  Dec 31, 2008
Nicotine Polacrilex Gum, coated mint flavor, is the generic equivalent of GlaxoSmithKline Consumer Healthcare's Nicorette (R) fresh mint gum, which is used ... Bloomberg

FDA Approves Novartis Consumer Health, Inc.'s Over-the-Counter …  -  Jun 22, 2007
...approval of Thrive(TM) (Nicotine Polacrilex Gum USP) 2mg and Thrive(TM) (Nicotine Polacrilex Gum USP) 4mg to help smokers quit smoking in 12 weeks. ... Free with registration - M2 Presswire - AccessMyLibrary.com

Coated nicotine polacrilex gum USP.  -  Jul 24, 2006
Coated nicotine polacrilex gum USP. Perrigo Co., Allegan, Mich., (800) 719-9260, is introducing mint-flavored coated nicotine polacrilex gum USP, ... $9.94 - Drug Topics - Alacra Store

Movers: Dell, Verifone, Viacom, Puget Energy  -  Dec 31, 2008
Says Nicotine Polacrilex Gum, coated mint flavor, is the generic equivalent of GSK's Nicorette fresh mint gum, which is used as an aid to smoking cessation. ... BusinessWeek

Coated nicotine polacrilex gum USP.(OTC)(Brief article)  -  Jul 24, 2006
Perrigo Co., Allegan, Mich., (800) 719-9260, is introducing mint-flavored coated nicotine polacrilex gum USP, 2 mg and 4 mg. The product, expected to be ... $4.95 - Drug Topics - ECNext

More In Business Briefs  -  Jun 26, 2007
Novartis Consumer Health announced that the FDA has granted approval to its Thrive (Nicotine Polacrilex Gum USP) 2mg and Thrive (Nicotine Polacrilex Gum ... Medical Marketing & Media - Medical Marketing and Media

Using combination therapy for smoking cessation.  -  May 1, 2005
The oldest nicotine replacement product, nicotine polacrilex gum, ... In 2002, nicotine polacrilex lozenges were granted FDA approval for OTC marketing. ... $4.95 - Clinician Reviews - ECNext

Perrigo gets FDA approval to market coated fruit nicotine gum  -  May 30, 2007
The first shipments of the product, coated nicotine polacrilex gum, is expected within the first quarter of fiscal 2008, the company said in a statement. ... Reuters

FDA Approves Over-The-Counter THRIVE Gum For Cessation Of …  -  Jun 27, 2007
Novartis Consumer Health, Inc., has announced that the US Food and Drug Administration (FDA) has given approval of ThriveTM (Nicotine Polacrilex Gum USP) ... Medical News Today - Medical News Today (press release)

Press Release: Watson Pharmaceuticals Receives FDA Approval for Mint ...  -  Dec 31, 2008
Nicotine Polacrilex Gum, coated mint flavor, is the generic equivalent of GlaxoSmithKline Consumer Healthcare's Nicorette (R) fresh mint gum, which is used ... Pay-Per-View - PR Newswire - HighBeam Research

Perrigo's Nicotene Gum Approved  -  Jun 14, 2006
Perrigo(PRGO Quote) said Wednesday that it received approval from the US Food and Drug Administration to market over-the-counter coated nicotine polacrilex ... TheStreet.com - TheStreet.com (subscription)

Factiva Search  -  Nov 3, 2006
New and generic drug approvals: Nicotine Polacrilex Gum. [1 table in original article]. 03 November, 2006 US Food and Drug Administration News ... Pay-Per-View - US Food and Drug Administration News - Factiva, from Dow Jones

Press Release: FDA Approves Novartis Consumer Health, Inc.'s Over-the...  -  Jun 22, 2007
...approval of Thrive(TM) (Nicotine Polacrilex Gum USP) 2mg and Thrive(TM) (Nicotine Polacrilex Gum USP) 4mg to help smokers quit smoking in 12 weeks. ... Pay-Per-View - PR Newswire - HighBeam Research

Press Release: FDA Approves Novartis Consumer Health, Inc.'s Over-the...  -  Jun 22, 2007
...approval of Thrive(TM) (Nicotine Polacrilex Gum USP) 2mg and Thrive(TM) (Nicotine Polacrilex Gum USP) 4mg to help smokers quit smoking in 12 weeks. ... Pay-Per-View - M2 Presswire - HighBeam Research

Perrigo Profit Tops View  -  Feb 2, 2006
Perrigo received approval from the US FDA to market OTC (over-the-counter) nicotine polacrilex lozenges whose brand name product sales at retail were ... TheStreet.com - TheStreet.com (subscription)

Death by drugs ; Anna Nicole's bizarre overdose details  -  Mar 27, 2007
Nicorette (nicotine polacrilex): Used to quit smoking. Noctec (chloral hydrate): Sedative and sleeping medication. Klonopin (clonazepam): Anti-seizure ... Pay-Per-View - Chicago Tribune - ProQuest Archiver

Elder launches nicotine replacement therapy gum  -  Mar 17, 2005
City-based Elder Pharmaceuticals Ltd has launched NuLife (nicotine polacrilex USP) chewing gum, a nicotine replacement therapy product (NRT) for tobacco ... expresspharmapulse.com

Smoking Cessation Gum Approved  -  Jun 25, 2007
The FDA has approved Novartis Consumer Health's Thrive (nicotine polacrilex) 2 and 4 mg gum to help smokers quit in 12 weeks. The Thrive smoking cessation ... Facts and Comparisons

Quit Smoking the NuLife way  -  Dec 31, 2005
The chewette contains Nicotine Polacrilex USP that is available in three strengths: 1 mg, 2 mg and 4 mg. The presentation was blister packaging as a strip ... Express Pharma

Perrigo Receives FDA Approval To Market Orange, Coated Nicotine Gum  -  Apr 28, 2008
...the US Food and Drug Administration (FDA) to market over-the-counter (OTC) Nicotine Polacrilex Gum USP, 2 mg (base) and 4 mg (base) (Orange, Coated). ... Lifescience-online

Article: Millions of acetaminophen pills recalled - Deseret News...  -  Nov 10, 2006
The FDA determined that Perrigo's nicotine polacrilex gum USP, 2 mg and ... store brand competitors in the market. The FDA also determined that Perrigo's ... Pay-Per-View - Deseret News - HighBeam Research

Article: Fed: Checkup column for November 25, 2005 - AAP General …  -  Nov 25, 2005
Only one previous econometric ... cessation aids. The first nicotine replacement therapy-nicotine polacrilex ... PR Newswire. Article: Increased Attempts to ... Pay-Per-View - AAP General News - HighBeam Research

Press Release: New Report: Smokers Should NEVER Use Nicotine …  -  Oct 31, 2008
...of over-thecounter nicotine replacement therapies. Only one ... cessation aids. The first nicotine replacement therapy-nicotine polacrilex ... ... Pay-Per-View - PR Newswire - HighBeam Research

Article: 11 million bottles of painkiller recalled - The Record...  -  Nov 10, 2006
The FDA determined that Perrigo's nicotine polacrilex gum USP, 2 mg and ... store brand competitors in the market. The FDA also determined that Perrigo's ... Pay-Per-View - The Record - HighBeam Research

Deseret News, The : At a glance: drugs taken by Anna Nicole Smith  -  Mar 27, 2007
Nicorette (nicotine polacrilex): used to quit smoking. -- Tamiflu (oseltamivir phosphate): anti-viral medicine. -- Vitamin B12: helps formation of red blood ... $2.95 - Deseret News - NewsBank

Perrigo given FDA approval for OTC nicotine gum.(OT-Cs)(Brief...  -  May 19, 2008
Watson Laboratories Inc. has received regulatory clearance to market its over-the-counter nicotine polacrilex gum USP (mint flavor) in 2- and 4-mg strengths ... Pay-Per-View - Chain Drug Review - HighBeam Research

Elder launches nicotine replacement therapy gum.  -  Mar 17, 2005
Elder Pharmaceuticals Ltd (Elder) has introduced a nicotine replacement therapy product (NRT), NuLife (nicotine polacrilex USP), in India in the form of ... Pay-Per-View - Express Pharma Pulse - Factiva, from Dow Jones

Smith died of accidental OD | Article from The Record (Bergen County,...  -  Mar 27, 2007
Nicorette (nicotine polacrilex): used to quit smoking. * Tamiflu (oseltamivir phosphate): anti-viral medicine. * Vitamin B12: helps formation of red blood ... Pay-Per-View - The Record - HighBeam Research

Cambrex Reports First Quarter 2006 Results.  -  Apr 27, 2006
Higher sales resulted from strong demand for a gastrointestinal API, x-ray contrast media and nicotine polacrilex used in smoking cessation products, ... $4.95 - PR Newswire - ECNext

Press Release: Perrigo Receives FDA Approval to Market Orange, …  -  Apr 24, 2008
...the U.S. Food and Drug Administration (FDA) to market over-the-counter (OTC) Nicotine Polacrilex Gum USP, 2 mg (base) and 4 mg (base) (Orange, Coated). ... Pay-Per-View - PR Newswire - HighBeam Research

Perrigo Company Reports Second Quarter Fiscal 2006 Financial Results.  -  Feb 2, 2006
...today that it has received approval from the US Food and Drug Administration (FDA) to market over-the-counter (OTC) nicotine polacrilex lozenges. ... $4.95 - PR Newswire - ECNext

Press Release: Radian Guaranty Launches Program to Keep Borrowers …  -  Apr 3, 2008
Hope Now is a national alliance ... com/index.html. Keywords: Radian Guaranty, Commit, Drugs, Nicotine Polacrilex ... ... Pay-Per-View - PR Newswire - HighBeam Research

Perrigo Receives FDA Approval To Market Coated Fruit Nicotine Gum  -  May 31, 2007
...the US Food and Drug Administration (FDA) to market over-the-counter coated nicotine polacrilex gum USP, 2 mg (coated fruit) and 4 mg (coated fruit). ... Medical News Today - Medical News Today (press release)

Auxilium Pharmaceuticals Announces Top-Line Results From Phase IV …  -  Jun 15, 2006
...from the US Food and Drug Administration (FDA) to market over-the-counter (OTC) coated nicotine polacrilex gum USP, 2 mg (mint) and 4 mg (mint). ... Free with registration - M2 Presswire - AccessMyLibrary.com

Nicotine gum.(OT-Cs)(Brief article) | Article from Chain Drug Review...  -  Jun 25, 2007
Watson Laboratories Inc. has received regulatory clearance to market its over-the-counter nicotine polacrilex gum USP (mint flavor) in 2- and 4-mg strengths ... Pay-Per-View - Chain Drug Review - HighBeam Research

Event Brief of Q3 2006 Cambrex Earnings Conference Call - Part 1.  -  Oct 3, 2006
Co. observed strong sales for a number of generic APIs, as well as nicotine polacrilex used in smoking cessation products. 3. As noted in 2Q06, ... Free with registration - America's Intelligence Wire - AccessMyLibrary.com

Finmin notifies indirect tax exemptions for withdrawal  -  Apr 11, 2006
The excise exemptions list include aviation turbine fuel, gibberellic acid, Nicotine polacrilex gum, tooth powder etc. Financial Express

BUD-TABLE-EXCISE  -  Feb 28, 2007
E) Nicotine polacrilex gum; F) Dust and powder of synthetic stones. 2) Exemption from excise duty on pan masala containing tobacco and other tobacco ... Free with registration - PTI - The Press Trust of India Ltd - AccessMyLibrary.com

Monitor the Financial Performance of Leading Generics Players with...  -  May 28, 2007
Nicotine polacrilex and ibuprofen Companies Mentioned Include: - Agis Industries - Bentley Pharmaceuticals - APG - Lannett - Peter Black Pharmaceuticals ... Free with registration - Business Wire - AccessMyLibrary.com

Article: Dr Scott's surgery.(News) - Evening Chronicle (Newcastle, …  -  Jan 9, 2006
CQ[R] Mint Gum is the only NRT gum with a free, highly tailored ... material as a supplement to nicotine polacrilex gum ... Pay-Per-View - Evening Chronicle - HighBeam Research

Press Release: Perrigo Receives FDA Approval to Market Coated Fruit …  -  May 30, 2007
...the U.S. Food and Drug Administration (FDA) to market over-the-counter coated nicotine polacrilex gum USP, 2 mg (coated fruit) and 4 mg (coated fruit). ... Pay-Per-View - PR Newswire - HighBeam Research

Press Release: Perrigo Company Receives FDA Approval to Market …  -  Jun 14, 2006
...from the U. S. Food and Drug Administration (FDA) to market over-the-counter (OTC) coated nicotine polacrilex gum USP, 2 mg (mint) and 4 mg (mint). ... Pay-Per-View - PR Newswire - HighBeam Research

EEUU aprueba goma de mascar de Watson para dejar de fumar  -  Dec 31, 2008
Watson planea lanzar comercialmente el producto, de menta y genéricamente conocido como Nicotine Polacrilex, a comienzos de enero. ... Buena Salud

Watson Pharmaceuticals, Inc.  -  Sep 17, 2007
Major generic products include nicotine polacrilex gum, USP; Quasense, an extended regimen birth control pill; hydrocodone and acetaminophen; oxycodone and ... $9.94 - Chain Drug Review - Alacra Store

Press Release: It's Valentine's Day, and the Tums(R) Smoothies(TM) …  -  Feb 9, 2007
GSK is also unveiling Commit nicotine polacrilex lozenges in cherry flavor. * Blistex Inc. is ... Food & Drug Packaging. Article: Tums now come in portable ... Pay-Per-View - PR Newswire - HighBeam Research

Article: Broad Recall of Acetaminophen Under Way - AP Online | …  -  Nov 10, 2006
The FDA determined that Perrigo's nicotine polacrilex gum USP, 2 mg and ... store brand competitors in the market. The FDA also determined that Perrigo's ... Pay-Per-View - Associated Press/AP Online - HighBeam Research

Article: Broad Recall of Acetaminophen Under Way - AP Online | …  -  Nov 11, 2006
The FDA determined that Perrigo's nicotine polacrilex gum USP, 2 mg and ... store brand competitors in the market. The FDA also determined that Perrigo's ... Pay-Per-View - Associated Press/AP Online - HighBeam Research

These OTCs/HBCs are brimming with flavors.(SELF-CARE)  -  Jan 8, 2007
GSK is also unveiling Commit nicotine polacrilex lozenges in cherry flavor. * Blistex Inc. is rolling out Blistex Lip Infusion Sheer Liquid Balm in Cherry ... $4.95 - Drug Topics - ECNext

Article: 11M Bottles of Acetaminophen Recalled - AP Online | HighBeam...  -  Nov 9, 2006
The FDA determined that Perrigo's nicotine polacrilex gum USP, 2 mg and ... store brand competitors in the market. The FDA also determined that Perrigo's ... Pay-Per-View - Associated Press/AP Online - HighBeam Research

Article: Massive Recall of Acetaminophen Underway - AP Online | …  -  Nov 9, 2006
The FDA determined that Perrigo's nicotine polacrilex gum USP, 2 mg and ... store brand competitors in the market. The FDA also determined that Perrigo's ... Pay-Per-View - Associated Press/AP Online - HighBeam Research

FDA first-time generics approvals--2006.(Special Report)(Statistical...  -  Feb 19, 2007
0.5 mg, Inc. 1 mg, 2 mg and 3 mg Testosterone gel 1% Watson Laboratories Androgel Inc. Nicotine polacrilex Perrigo R&D Co. Commit lozenges, 2 mg and 4 ... Pay-Per-View - Chain Drug Review - HighBeam Research

PERRIGO GETS FDA APPROVAL FOR SMOKING-CESSATION GUM  -  Jun 20, 2006
Perrigo has received approval from the FDA to market OTC coated nicotine polacrilex gum in 2-mg and 4-mg dosages. The company said it expects to begin ... Pay-Per-View - FDAnews Drug Pipeline Alert - Factiva, from Dow Jones

Victoria Advocate, The : DRUGS TAKEN BY ANNA NICOLE SMITH  -  Mar 27, 2007
Nicorette (nicotine polacrilex): used to quit smoking. Tamiflu (oseltamivir phosphate): anti-viral medicine. Vitamin B12: helps formation of red blood cells ... $2.95 - Victoria Advocate - NewsBank

Article: Massive Recall of Acetaminophen Underway - AP Online | …  -  Nov 10, 2006
The FDA determined that Perrigo's nicotine polacrilex gum USP, 2 mg and ... store brand competitors in the market. The FDA also determined that Perrigo's ... Pay-Per-View - Associated Press/AP Online - HighBeam Research

Press Release: US Appeals Court Upholds Lipitor's Basic Patent With …  -  Aug 2, 2006
Nicotine Polacrilex Gum. The Appeals Court also directed the District ... In its decision, the Appeals Court found that Watson "cannot ... through PR ... Pay-Per-View - PR Newswire - HighBeam Research

Factiva Search  -  Jun 27, 2006
Perrigo has received approval from the FDA to market OTC coated nicotine polacrilex gum in 2-mg and 4-mg dosages. The ... ... Pay-Per-View - FDAnews Drug Daily Bulletin - Factiva, from Dow Jones

Article: Antismoking.(OTC BEST-SELLERS)(Statistical table)(Brief...  -  Jan 1, 2007
Nicorette gum (nicotine polacrilex) became the ... prescription to OTC status. FDA approved Nicorette gum for adults last Feb. 9 in both 2 . ... Pay-Per-View - Chain Drug Review - HighBeam Research

Associated Press Archive: At a glance: Drugs taken by Anna Nicole...  -  Mar 27, 2007
Nicorette (nicotine polacrilex): used to quit smoking. -- Tamiflu (oseltamivir phosphate): anti-viral medicine. -- Vitamin B12: helps formation of red blood ... $2.95 - Associated Press Archive - NewsBank

Article: Broad Recall of Acetaminophen Under Way - AP Online | …  -  Nov 12, 2006
The FDA determined that Perrigo's nicotine polacrilex gum USP, 2 mg and ... store brand competitors in the market. The FDA also determined that Perrigo's ... Pay-Per-View - Associated Press/AP Online - HighBeam Research

These OTCs/HBCs are brimming with flavors.  -  Jan 8, 2007
GSK is also unveiling Commit nicotine polacrilex lozenges in cherry flavor. * Blistex Inc. is rolling out Blistex Lip Infusion Sheer Liquid Balm in Cherry ... $9.94 - Drug Topics - Alacra Store

Article: 11M Bottles of Acetaminophen Recalled - AP Online | HighBeam...  -  Nov 9, 2006
The FDA determined that Perrigo's nicotine polacrilex gum USP, 2 mg and ... store brand competitors in the market. The FDA also determined that Perrigo's ... Pay-Per-View - Associated Press/AP Online - HighBeam Research

Article: Massive Recall of Acetaminophen Underway - AP Online | …  -  Nov 10, 2006
The FDA determined that Perrigo's nicotine polacrilex gum USP, 2 mg and ... store brand competitors in the market. The FDA also determined that Perrigo's ... Pay-Per-View - Associated Press/AP Online - HighBeam Research

Article: Perrigo's headache: company recalls 11 million bottles of...  -  Dec 1, 2006
The FDA determined that Perrigo's nicotine polacrilex gum USP, 2 mg and ... store brand competitors in the market. The FDA also determined that Perrigo's ... Pay-Per-View - Skin & Allergy News - HighBeam Research

Article: 11M Bottles of Acetaminophen Recalled - AP Online | HighBeam...  -  Nov 9, 2006
The FDA determined that Perrigo's nicotine polacrilex gum USP, 2 mg and ... store brand competitors in the market. The FDA also determined that Perrigo's ... Pay-Per-View - Associated Press/AP Online - HighBeam Research

פריגו קיבלה ×?ישור לשיווק גרס×? גנרית של מסטיק למניעת עישון  -  Apr 25, 2008
FDA לשיווק מוצר מדף למניעת עישון, מסטיק מסוג Nicotine Polacrilex בטע×? תפוז, במינוני×? של 2 ו-4 מ"×’. ... Bizportal

Drikk nikotin mot røykesug  -  Jul 17, 2006
Det ble søkt om å kunne lage to styrkegrader av drikken - en med 2 mg nikotinbase (Nicotine Polacrilex) pr 240 milliliter drikke og en variant med 4 ... Teknisk Ukeblad

Brand Names/Synonyms:
Nicotine Polacrilex is also known by the following brand names and/or synonymsBlack Leaf; Black Leaf 40; Campbell's Nico-Soap; Commit; Destruxol Orchid Spray; Emo-Nik; Flux Maag; Fumetobac; Habitrol; L-Nicotine; Mach-Nic; Niagara P.A. Dust; Nic-Sal; Nico-Dust; Nico-Fume; Nicocide; Nicoderm; Nicoderm Cq; Nicorette; Nicorette Plus; Nicotin; Nicotina; Nicotine; Nicotine Alkaloid; Nicotine Polacrilex; Nicotrol; Nicotrol Inhaler; Nicotrol Ns; Nikotin; Nikotyna; Ortho N-4 Dust; Ortho N-5 Dust; Prostep; Tendust; Tetrahydronicotyrine, Dl-; Xl All Insecticide

Drug Category:
Nicotine Polacrilex is categorized under the following by the FDA: Anti-craving Agents; Central Nervous System Agents; Autonomic drugs; Nicotinic Agonists; ATC:N07BA01

Dosage Forms:
Gum, Inhaler, Patches

Absorption:
Absorption of nicotine through the buccal mucosa is relatively slow and the high and rapid rise followed by the decline in nicotine arterial plasma concentrations seen with cigarette smoking are not achieved with the inhaler. About 10% of absorbed nicotine is excreted unchanged in urine.

Interactions:
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Chemical IUPAC Name:
3-(1-methylpyrrolidin-2-yl)pyridine





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