Nisoldipine

This page contains recent news articles, when available, and an overview of Nisoldipine but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Nisoldipine
(when available)

Pharmacology and use:
Nisoldipine, a dihydropyridine calcium-channel blocker, is used alone or with an angiotensin-converting enzyme inhibitor, to treat hypertension, chronic stable angina pectoris, and Prinzmetal's variant angina. Nisoldipine is similar to other peripheral vasodilators. Nisoldipine inhibits the influx of extra cellular calcium across the myocardial and vascular smooth muscle cell membranes possibly by deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum. The decrease in intracellular calcium inhibits the contractile processes of the myocardial smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload. Hypertension

Mechanism Of Action:
By deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum, Nisoldipine inhibits the influx of extracellular calcium across the myocardial and vascular smooth muscle cell membranes The decrease in intracellular calcium inhibits the contractile processes of the myocardial smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload.

News Articles on Nisoldipine

Sciele shares fall as Mylan launches generic Sular  -  Jul 28, 2008
Sciele's new versions of Sular, which is known generically as nisoldipine, are reformulated to have less of the active drug ingredient, ... Reuters UK

Skyepharma to develop improved version of Sular for First Horizon  -  May 22, 2006
...a novel controlled-release version of Sular (nisoldipine), an antihypertensive used to reduce blood pressure. This is First Horizon's largest product. ... Forbes

Nisoldipine (Systemic).  -  Oct 27, 2005
Nisoldipine (NYE-sole-di-peen) is a calcium channel blocking agent used to treat high blood pressure. Nisoldipine affects the movement of calcium into the ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

(SCRX) SqueezeTrigger Price is $22.420. There is $245,027,268.00 That...  -  Aug 10, 2007
Nisoldipine, the active ingredient in Sular, belongs to a group of ... Nisoldipine selectively relaxes the muscles of small arteries causing them to dilate ... $4.95 - M2 Presswire - ECNext

Did therapy cause thrombosis?(CLINICAL TWISTERS)  -  Jul 24, 2006
He also asks you to recommend an alternative drug (to nisoldipine) for L.R.'s ... There is no documented evidence that nisoldipine causes superficial venous ... $4.95 - Drug Topics - ECNext

Competitors by Product Report  -  Aug 2, 2008
Sciele Pharma Inc. (SCRX) Products:. Controlled Release Sular (Nisoldipine); Sular (Nisoldipine). SkyePharma PLC (ADR) (SKYEY) Products: ... $75.00 - Revere Reports - Revere

SkyePharma - Research Update  -  May 14, 2007
Nisoldipine is a calcium channel blocker that prevents calcium from entering ... Nisoldipine selectively relaxes the muscles of small arteries causing them ... Genetic Engineering News - Genetic Engineering News (press release)

… hypertendus : l'incidence des IDM est plus élevée sous nisoldipine...  -  Nov 25, 2006
The effect of nisoldipine as compared with enalapril on cardiovascular outcomes in ... Les patients ont été assignés à la nisoldipine, 10 mg/j, la posologie ... EBM Journal (Abonnement)

Ketoconazole Oral : Uses, Side Effects, Interactions, Pictures,...  -  May 20, 2008
Heinig R, Adelmann HG, Ahr G. The effect of ketoconazole on the pharmacokinetics, pharmacodynamics and safety of nisoldipine. Eur J Clin Pharmacol 1999 Mar ... WebMD

Mylan Wins Final Approval for Generic Hypertension Drug  -  Jul 29, 2008
Mylan's nisoldipine extended-release (ER) tablets, indicated for the treatment of ... Mylan's Nisoldipine ER, which is being shipped immediately, ... RedOrbit

Press Release: Mylan Launches First Generic Version of Antihypertensiv...  -  Jul 28, 2008
Nisoldipine ER Tablets, indicated for the treatment of hypertension, are the generic version of Sciele Pharma's Sular(R) ER Tablets, which had annual U.S. ... Pay-Per-View - PR Newswire - HighBeam Research

Competitors by Product Report  -  Aug 2, 2008
Sciele Pharma Inc. (SCRX) Products:. Controlled Release Sular (Nisoldipine); Sular (Nisoldipine). SkyePharma PLC (ADR) (SKYEY) Products: ... $75.00 - Revere - Alacra Store

약업신문 www.yakup.com  -  Mar 3, 2007
...특히 nimodipine� 뇌혈관� 특�성� 있고, nisoldipine� 관�혈관� 선��으로 ... Amlodipine과 nisoldipine, 그리고 SR(sustained release) 제형� 제외한 모든 ... 약업신문

Event Brief of Q4 2006 Sciele Pharma, Inc. Earnings Conference Call -...  -  Feb 22, 2007
For Sular longer-term, SCRX is in the preclinical stage of development on a new nisoldipine compound with Bayer. 1. This will involve isolatings of ... Free with registration - Fair Disclosure Wire - AccessMyLibrary.com

Skyepharma PLC - Interim Results.  -  Sep 28, 2006
We also announced one new partnered project (a controlled release version of Sular(R) (nisoldipine), the lead product of Sciele Pharma, our US partner for ... Free with registration - Europe Intelligence Wire - AccessMyLibrary.com

SkyePharma PLC Interim Results Announcement for the Six Months …  -  Jun 30, 2006
We also announced one new partnered project (a controlled release version of Sular(R) (nisoldipine), the lead product of Sciele Pharma, our US partner for ... prnewswire.com

(SCRX) SqueezeTrigger Price is $22.879. There is $216,242,370.00 That...  -  Dec 6, 2007
Nisoldipine, the active ingredient in Sular, belongs to a group of ... Nisoldipine selectively relaxes the muscles of small arteries causing them to dilate ... $4.95 - M2 Presswire - ECNext

Mylan Launches Generic Hypertension Drug  -  Aug 5, 2008
Mylan's nisoldipine ER is the first generic version of Sular ER (nisoldipine) to be launched in the US, the firm said. The '741 patent protecting the brand ... FDA news - FDA news (subscription)

Competitors by Product Report  -  Jan 27, 2007
Sciele Pharma Inc. (SCRX) Products:. Controlled Release Sular (Nisoldipine) ... Controlled Release Sular (Nisoldipine) ... $75.00 - Revere Reports - Revere

Management of grapefruit-drug interactions.  -  Aug 15, 2006
Relationship between time after intake of grapefruit juice and the effect on pharmacokinetics and pharmacodynamics of nisoldipine in healthy subjects. ... Free with registration - American Family Physician - AccessMyLibrary.com

Competitors by Product Report  -  Oct 4, 2008
Products:. Controlled Release Sular (Nisoldipine); Sular (Nisoldipine). Abbott Laboratories (ABT) Products:. Isoptin SR (Verapamil Hydrochloride) ... $75.00 - Revere - Alacra Store

(SCRX) SqueezeTrigger Price is $22.876. There is $214,615,644.00 That...  -  Jan 3, 2008
Nisoldipine, the active ingredient in Sular, belongs to a group of ... Nisoldipine selectively relaxes the muscles of small arteries causing them to dilate ... $4.95 - M2 Presswire - ECNext

Management of grapefruit-drug interactions.  -  Aug 15, 2006
Relationship between time after intake of grapefruit juice and the effect on pharmacokinetics and pharmacodynamics of nisoldipine in healthy subjects. ... $4.95 - American Family Physician - ECNext

Company Profile Report  -  Oct 4, 2008
Sular (Nisoldipine); Controlled Release Sular (Nisoldipine). Digestive System. Gastrointestinal Tract Disorders. Stomatognathic Disorders ... $50.00 - Revere Reports - Revere

Company Profile Report  -  Oct 4, 2008
Controlled Release Sular (Nisoldipine); Sular (Nisoldipine). Digestive System. Gastrointestinal Tract Disorders. Stomatognathic Disorders ... $50.00 - Revere - Alacra Store

Foods to avoid when you're taking meds  -  Oct 26, 2006
...including calcium channel blockers, such as felodipine (Plendil), nisoldipine (Sular), and nifedipine (Procardia.) Drugs acting on the immune system, ... msnbc.com

Rescue Response  -  Oct 7, 2005
...remain on the formulary including Diltiazem (except extended release for bedtime dosing), Verapamil, Felodipine, Nifedipine, Nimodipine and Nisoldipine. ... Military.com

Treatment for Digital Ulcers Due to Raynaud's Phenomenon  -  Nov 17, 2005
Calcium channel blockers such as nifedipine, amlodipine, diltiazem, felodipine, nisoldipine, and isradipine have been reported to be effective in RP ... Medscape

Force of blood  -  Nov 12, 2006
...diltiazem HCl, felodipine, isradipine, lercanidipine HCl, lacidipine, nifedipine, nicardipine HCL, nimodipine, nisoldipine, and verapamil HCl. ... Malaysia Star

Calcium channel blocker ingestion: an evidence-based consensus …  -  Dec 1, 2005
...nimodipine, nisoldipine, and verapamil). These drugs block the entry of calcium through cellular membrane voltage-sensitive calcium channels. ... Free with registration - Clinical Toxicology - AccessMyLibrary.com

Calcium channel blockers  -  Jul 25, 2008
Newer calcium channel blockers (amlodipine, felodipine, isradipine, lacidipine, lercadipine and nisoldipine) cause less serious side effects.[3] guardian.co.uk

Your guide to hypertension  -  Jul 9, 2006
Calcium-channel blockers: such as Amlodipine, Nisoldipine, Diltiazem, Verapamil, Felodipine, Isradipine, Lacidipine, Nicardipine and Nifedipine. ... Daily Mail

First Horizon Announces Results for the First Quarter Ended March 31,...  -  Apr 28, 2005
Net revenues of the Company's Cardiology products, which include Sular (nisoldipine) and Nitrolingual (nitroglycerin), were $19.5 million, or 48% of total ... $4.95 - Business Wire - ECNext

Calcium channel blockers for heart attack and unstable angina  -  May 14, 2007
Amlodipine, felodipine, and nisoldipine are less likely to make heart failure worse. Nifedipine, nicardipine, amlodipine, and felodipine are used most ... MSN Health & Fitness

Kansas Regulations - 129-5-1. Prior authorization.  -  Nov 3, 2005
...with the following brand names: (i) Nifedical XL® and (ii) Procardia XL® and all generic equivalents; (D) nisoldipine; (E) felodipine; (F) isradipine; ... Pay-Per-View - Kansas Regulations - Loislaw

Chronotherapy With Nifedipine GITS in Hypertensive Patients: Improved...  -  Mar 31, 2008
...diltiazem, isradipine, nifedipine, nisoldipine, and nitrendipine. According to results from these studies, all limited by their small sample size, ... Nature.com

SkyePharma posts six-month results  -  Sep 20, 2007
The clinical trial programme for the company's new formulation of Sular, (nisoldipine CR), a calcium channel blocking agent for the treatment of high blood ... In-PharmaTechnologist.com

Cardiovascular Research; Automaticity was more easily induced by Ba2+...  -  Nov 8, 2005
The pharmacological responses to quinidine, nisoldipine, D-sotalol, 4-aminopyridine, isoproterenol, acetylcholine, and adenosine were characteristic of ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

Lipitor and Grapefruit interaction  -  Apr 19, 2007
...interacts are: High Blood pressure Drugs used to control blood pressure – felodipine (Plendil), nifedipine (Procardia) and nisoldipine (Sular). ... businessportal24.com

Running, jumping increase back pain.(SPORTS)(WEEKEND ATHLETE: …  -  Dec 24, 2006
The following drugs should not be taken with grapefruit juice: calcium channel blockers such as felodipine, nitrendipine, nisoldipine, nifedipine, ... $4.95 - Washington Times - ECNext

Southern Illinoisan : Grapefruit: The drugs it can affect  -  Jan 4, 2005
Calcium Blockers: felodipine (Plendil), nicardipine (Cardene), nifedipine (Procardia, Adalat), nimodipine (Nimotop), nisoldipine (Sular). ... $2.95 - Southern Illinoisan - NewsBank

New Sular formulation bioequivalent in trials.(Sciele Pharma)(Brief...  -  May 21, 2007
SkyePharma and US firm Sciele Pharma have completed clinical trials of a new formulation of the high blood pressure treatment Sular (nisoldipine). ... Free with registration - Pharma Marketletter - AccessMyLibrary.com

Drugs to combat hypertension  -  Apr 13, 2005
Calcium antagonists are drugs that usually end with the syllable "-pine" like felodipine, nicardipine and nisoldipine. But they are very expensive. ... Sun.Star

How to take Zafirlukast from Consumer Reports Health.  -  Jan 1, 2007
...isradipine (Dynacirc), nicardipine (Cardene), nifedipine (Adalat, Procardia, others), nimodipine (Nimotop), nisoldipine (Sular), or verapamil (Calan, ... consumerreports.org

Comparison between valsartan and valsartan plus cilnidipine in type...  -  May 17, 2006
...efonidipine 1, nicardipine 2, nifedipine 7, nilvadipine 2, nisoldipine 1, and diltiazem 4) 4 weeks before study entry and were replaced with diuretics, ... Nature.com

How to take Imatinib from Consumer Reports Health.  -  Jan 10, 2007
...isradipine (Dynacirc), nicardipine (Cardene), nifedipine (Adalat, Procardia, others), nimodipine (Nimotop), nisoldipine (Sular), or verapamil (Calan, ... consumerreports.org

Lowering high blood pressure  -  May 27, 2005
Calcium antagonists are drugs that usually end with the syllable "-pine" like felodipine, nicardipine and nisoldipine. But they are very expensive. ... Sun.Star

FDA approval for Skye, Sciele blood pressure med  -  Jan 3, 2008
Sciele and SkyePharma this week announced the approval of their controlled release formulation of high blood pressure drug Sular (nisoldipine). ... In-PharmaTechnologist.com

SkyePharma Business Review Day 2006.  -  Jun 21, 2006
Mr. Fourteau is also presenting on the controlled release formulation that SkyePharma is developing for Sciele of its lead product Sular(R) (nisoldipine), ... Free with registration - PR Newswire - AccessMyLibrary.com

Mayo Clinic expertise  -  Nov 16, 2007
Examples include nifedipine (Adalat, Procardia), amlodipine (Norvasc), diltiazem (Cardizem, Dilacor), felodipine (Plendil), nisoldipine (Sular) and ... MayoClinic.com

Management of Grapefruit-Drug Interactions  -  Aug 15, 2006
Relationship between time after intake of grapefruit juice and the effect on pharmacokinetics and pharmacodynamics of nisoldipine in healthy subjects. ... AAFP News Now

Delavirdine (Systemic).  -  Feb 1, 2006
Plendil) or Isradipine (eg, DynaCirc) or Nicardipine (eg, Cardene) or Nifedipine (eg, Adalat) or Nimodipine (eg, Nimotop) or Nisoldipine (eg, ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

BP-lowering calcium channel blocker  -  Nov 10, 2008
Other drugs in this class include amlodipine, felodipine, nifedipine, and nisoldipine. In vivo studies indicate that this drug reduces mean arterial BP by ... Clinical Advisor

Racial Differences in Response to Fosinopril in Hypertensive Children:...  -  Sep 13, 2006
The effect of nisoldipine as compared with enalapril on cardiovascular outcomes in patients with noninsulin dependent diabetes and hypertension. ... Medscape

What are the long term effects of taking sular  -  Jul 7, 2008
Sular, the brand name for nisoldipine, is a new blood pressure medication in a class of drugs known as calcium channel blockers. This class of medication ... HealthCentral.com

Sciele Pharma reaffirms 2007 guidance.  -  Jan 21, 2008
Sciele also revealed plans to launch several new products this year, including four new formulations of the hypertension treatment Sular (nisoldipine), ... Free with registration - Pharma Marketletter - AccessMyLibrary.com

Eating Smarter to Reduce Acid Reflux  -  Jul 13, 2006
...felodipine, nifedipine, nisoldipine, and verapamil), anticholinergic drugs (including benztropine, biperiden, dicyclomine, hyoscyamine, isopropamide, ... HealthCentral.com

Delavirdine (Systemic).(Drug overview)  -  Aug 1, 2006
Plendil) or Isradipine (eg, DynaCirc) or Nicardipine (eg, Cardene) or Nifedipine (eg, Adalat) or Nimodipine (eg, Nimotop) or Nisoldipine (eg, ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Collaboration between Biotech and Pharmaceutical Companies: April 27 ...  -  Jun 5, 2006
SKYE) Pharmaceutical controlled release version Corp. of First Horizon's hypertension drug Sular (nisoldipine) SkyePharma Kos Kos got exclusive rights ... Free with registration - Bioworld Financial Watch - AccessMyLibrary.com

Time to get back to our scientific basics  -  Aug 23, 2006
This is just what happened with the DEFIANT and DEFIANT II studies with nisoldipine about 10 years ago. It happens between phases as well. ... Pharmafocus

By the way, doctor; What's the problem with grapefruit juice and...  -  Jul 1, 2006
...diltiazem (Cardizem, others) felodipine (Plendil) nicardipine (Cardene) nifedipine (Procardia, Adalat) nisoldipine (Sular) verapamil (Covera, Verelan) ... Free with registration - Harvard Heart Letter - AccessMyLibrary.com

First Horizon sees growing partnership with Bayer.(FIRST HORIZON …  -  Jan 16, 2006
...foreign currency exchange rate protection; and the opportunity for expanded international distribution rights for Sular (nisoldipine). ... Free with registration - Pharma Marketletter - AccessMyLibrary.com

FDA accepts Sular sNDA.( supplemental New Drug Application)(Brief …  -  Sep 17, 2007
Drug Administration has accepted a supplemental New Drug Application for the latter's new formulation of the hypertension treatment Sular (nisoldipine). ... $4.95 - Pharma Marketletter - ECNext

Press Release: Barr's Generic Version of Estrostep(R) Fe Tablets …  -  Oct 26, 2007
Nisoldipine ER, which is being shipped immediately, is the first generic version of Sular ER to be introduced in the United States. Currently ... ... Pay-Per-View - PR Newswire - HighBeam Research

By the way, doctor; What's the problem with grapefruit juice and...  -  Jul 1, 2006
...diltiazem (Cardizem, others) felodipine (Plendil) nicardipine (Cardene) nifedipine (Procardia, Adalat) nisoldipine (Sular) verapamil (Covera, Verelan) ... Pay-Per-View - Harvard Heart Letter - Factiva, from Dow Jones

Stock Commentary - Europe - week to May 14, 2007.  -  May 21, 2007
...while drug-delivery specialist SkyePharma gained 5.4% after clinical trials of a new formulation of hypertension drug Sular (nisoldipine), ... $9.94 - Pharma Marketletter - Alacra Store

FDA accepts Sular sNDA.  -  Sep 17, 2007
Drug Administration has accepted a supplemental New Drug Application for the latter's new formulation of the hypertension treatment Sular (nisoldipine). ... $9.94 - Pharma Marketletter - Alacra Store

Press Release: Mylan Announces Final FDA Approval for Generic …  -  Jun 16, 2008
Mylan's Nisoldipine ER ... immediately, is the first generic version of Sular ER to be introduced ... States. Currently, Mylan has 93 ANDAs pending ... ... Pay-Per-View - PR Newswire - HighBeam Research

Cardiology; Studies from Germany, Canada and Taiwan add new findings …  -  May 3, 2006
The pharmacological responses to quinidine, nisoldipine, D-sotalol, 4-aminopyridine, isoproterenol, acetylcholine, and adenosine were characteristic of ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

Advancis Pharmaceutical Corporation.(Update) | Article from Medical …  -  Aug 1, 2006
...named LM&P Biostar, a division of LM&P Euro RSCG, as its agency of record for the U.S. re-launch of SULAR (nisoldipine), ah antihypertensive medication. ... Pay-Per-View - Medical Marketing & Media - HighBeam Research

Stock Commentary - Europe - week to Jan 7, 2008.  -  Jan 14, 2008
...shot up 12.2% on the news that the US Food and Drug Administration has approved new formulations of the calcium channel blocker Sular (nisoldipine), ... $9.94 - Pharma Marketletter - Alacra Store

Mylan Inc.  -  Sep 29, 2008
In that respect, Mylan has benefited from such launches as paroxetine ER, nisoldipine ER, ropinirole HCl and galantatamine. On the political front, ... $9.94 - Chain Drug Review - Alacra Store

Skyepharma further reduces loss in first half.  -  Sep 1, 2008
...the launch of recently-approved products, Requip XL (ropinirole) and the new formulation of Sular (nisoldipine), and additional contract development. ... $9.94 - Pharma Marketletter - Alacra Store

FDA clears new Sular formulations.  -  Jan 7, 2008
Food and Drug Administration has approved new formulations of the calcium channel blocker Sular (nisoldipine) for the treatment of high blood pressure. ... $9.94 - Pharma Marketletter - Alacra Store

Press Release: Mylan Receives FDA Approval for Generic Version of …  -  Sep 22, 2008
Mylan's Nisoldipine ER ... immediately, is the first generic version of Sular ER to be introduced ... States. Currently, Mylan has 93 ANDAs pending ... ... Pay-Per-View - PR Newswire - HighBeam Research

Press Release: SkyePharma to Develop Improved Controlled Release …  -  May 22, 2006
...("First Horizon") to develop a novel controlled-release version of Sular (nisoldipine), an antihypertensive that is First Horizon's largest product. ... Pay-Per-View - PR Newswire - HighBeam Research

Revue : le contrôle rigoureux de la pression artérielle et le...  -  Nov 25, 2006
Dans un des essais, l'incidence des infarctus du myocarde mortels et non mortels a été plus élevée sous nisoldipine, un antagoniste calcique, ... EBM Journal (Abonnement)

Các loại thuốc phản ứng vá»›i quả nho  -  Apr 19, 2007
Các loại thuốc đi�u trị huyết áp cao, bao gồm felodipine (Plendil), nifedipine (Procardia) and nisoldipine (Sular). - Các loại thuốc dùng đi�u trị chứng ... VNMedia

Calcium and arrhythmogenesis.  -  Apr 1, 2007
Under these conditions this channel spontaneously opens, has a relatively low conductance, is not blocked by nisoldipine, and is reasonably selective for ... Free with registration - Physiological Reviews - AccessMyLibrary.com

心绞痛-å?¥åº·é¢‘é?“-西部网(陕西新闻网)www.cnwest.com  -  Sep 11, 2007
...新的制剂有尼�地平(nicardipine)10~20mg 3次/d,尼索地平(nisoldipine)20mg 2 次/d,氨氯地平(amlodipine)5~10mg 1次/d,�洛地平(felodipine)5~20mg 1 ... 西部网

Substantial progress has been made in treatments for organ-specific …  -  Oct 1, 2007
Nisoldipine Nizatidine Octreotide acetate Olmesartan Omeprazole Pantoprazole Pentoxifylline Pravastatin Prazosin Rabeprazole Ranitidine Rifaximin ... $4.95 - Journal of Musculoskeletal Medicine - ECNext

Brand Names/Synonyms:
Nisoldipine is also known by the following brand names and/or synonymsBay K 5552; Bay-K 5552; Baymycard; CHEMBANK2652; Nisocor; Nisoldipin; Nisoldipine; Nisoldipine [Usan:Ban:Inn:Jan]; Nisoldipino [Inn-Spanish]; Nisoldipinum [Inn-Latin]; Norvasc; Sular; Syscor; Zadipina

Drug Category:
Nisoldipine is categorized under the following by the FDA: Vasodilator Agents; Antihypertensive Agents; ATC:C08CA07

Dosage Forms:
Not Available

Absorption:
Not Available

Interactions:
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Chemical IUPAC Name:
methyl2-methylpropyl2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate





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