Novantrone

This page contains recent news articles, when available, and an overview of Novantrone but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Novantrone
(when available)

Pharmacology and use:
Mitoxantrone has been shown in vitro to inhibit B cell, T cell, and macrophage proliferation and impair antigen presentation, as well as the secretion of interferon gamma, TNFa, and IL-2. For the treatment of secondary (chronic) progressive, progressive relapsing, or worsening relapsing-remitting multiple sclerosis

Mechanism Of Action:
Mitoxantrone, a DNA-reactive agent that intercalates into deoxyribonucleic acid (DNA) through hydrogen bonding, causes crosslinks and strand breaks. Mitoxantrone also interferes with ribonucleic acid (RNA) and is a potent inhibitor of topoisomerase II, an enzyme responsible for uncoiling and repairing damaged DNA. It has a cytocidal effect on both proliferating and nonproliferating cultured human cells, suggesting lack of cell cycle phase specificity.

News Articles on Mitoxantrone

New Oral Agent, Tasquinimod, May Have Activity in Prostate Cancer  -  ‎Oct 26, 2009‎
Chemotherapy agents for patients with HRPC include: Taxotere® (docetaxel), Emcyt® (estramustine), Novantrone® (mitoxantrone), ixabepilone, ... Cancer Consultants

BUYINS.NET: FFIV, PTV, OSIP, RJF, CFR, DST Expected To Be Higher After ...  -  ‎Oct 19, 2009‎
The company also offers Novantrone, a mitoxantrone for injection concentrate. OSI Pharmaceuticalsa products in Phase I clinical trials include OSI-906, ... Trading Markets (press release)

Heart, Leukemia Warning for MS Drug Novantrone  -  May 27, 2005
By Miranda Hitti. The FDA is warning doctors and multiple sclerosis (MS) patients about the risk of heart failure and leukemia from the MS drug Novantrone. ... FOXNews

Novantrone Treatment for MS - WebMD  -  Nov 2, 2006
Novantrone is a drug that works by suppressing the immune system to lessen its attack on the body. It can slow increases in disability and reduce the ... WebMD

Swiss shares close slightly higher led by Novartis, Nestle; financials...  -  May 25, 2005
The FDA said it has provided additional information concerning the risks of cardiotoxicity associated with Novantrone, and supplemental information ... Forbes

Dabur Pharma gets FDA nod for prostrate cancer drug  -  May 22, 2008
...(ANDA) to market its generic version of EMD Serono's Novantrone (Mitoxantrone Hydrochloride) Injection used in the treatment for prostrate cancer. ... सिफी - सिफी

Swiss shares move off highs in thin pre-holiday trade ahead of Wall...  -  Apr 13, 2006
...it has received FDA approval for its abbreviated new drug application for mitoxantrone injection, USP, the generic equivalent of Serono Novantrone. ... Forbes

Mitoxantrone for multiple sclerosis  -  Feb 28, 2008
Mitoxantrone (Novantrone) is an immunosuppressant, a type of medication that ... Mitoxantrone (Novantrone) is one of only two medications that have been ... WebMD

FDA Orders Labeling Change for Novantrone  -  May 20, 2005
...by John C. Martin. The government has ordered that a boxed warning be added to the labeling of the multiple sclerosis medication, Novantrone ... MS Neighborhood

Teva's generic version of Novantrone gets FDA OK.  -  Apr 12, 2006
SAN FRANCISCO (MarketWatch) -- Teva Pharmaceutical Industries Ltd. said Wednesday its generic version of Serono SA's Novantrone injection has been approved ... Free with registration - America's Intelligence Wire - AccessMyLibrary.com

FDA Changes Novantrone Labeling  -  Oct 16, 2005
By Anonymous. The US Food and Drug Administration (FDA) announced that it has changed the labeling of Novantrone (mitoxantrone) to include a boxed warning. ... RedOrbit

First-Time Generic Approvals: Novantrone, Terazol 3, Norco  -  Apr 14, 2006
April 14, 2006 -- The US Food and Drug Administration (FDA) has approved first-time generic formulations of mitoxantrone HCl 2-mg/mL injection for the ... Medscape

Gain Insight into Upcoming Treatments for Multiple Sclerosis with New...  -  May 17, 2007
Copaxone, Novantrone, and Tysabri. Dosing and drug storage and preparation information is provided, along with the annual cost for each therapy. ... Free with registration - Business Wire - AccessMyLibrary.com

Novantrone label now reflects new risks.(BREAKING NEWS ...)(Brief …  -  Jun 6, 2005
Healthcare professionals have been notified by Serono and the FDA of revisions to the labeling for mitoxantrone (Novantrone), indicated for the treatment of ... Free with registration - Drug Topics - AccessMyLibrary.com

FDA Safety Labeling Changes: Novantrone, Mevacor, Nitro-Dur  -  Jul 6, 2005
July 6, 2005 — The US Food and Drug Administration (FDA) approved in April revisions to safety labeling to advise that use of mitoxantrone is associated ... Medscape

Real-Life Mitoxantrone (Novantrone) Study Confirms Efficacy, Safety...  -  Oct 3, 2005
By Bruce Sylvester. THESSALONIKI, GREECE -- October 3, 2005 -- A real-life, postapproval study of mitoxantrone (Novantrone) confirms the drug's efficacy as ... DG News

Mayne Announces FDA Approval of Mitoxantrone  -  Apr 11, 2006
Mitoxantrone is a generic equivalent to Serono's Novantrone(R) which generated annual sales of approximately $75 million in 2005. ... RedOrbit

Serono "sell"  -  Oct 23, 2006
The FDA has indicated that the company's Novantrone drug exhibits undesirable side effects and can cause heart damage. The report by the FDA is unlikely to ... newratings.com

Serono Delivers Second Quarter EPS of $12.92, Up 25.2% on Adjusted(1 …  -  Jul 26, 2006
Novantrone(R) sales in the second quarter of 2006 were $5.4m, down 70.4%, consequent to the introduction of generics of mitoxantrone in the US in April 2006 ... $4.95 - PR Newswire - ECNext

OSI Pharmaceuticals to Present at the Merrill Lynch Global …  -  Feb 2, 2005
OSI exclusively markets Novantrone(R) (mitoxantrone concentrate for injection) for the approved oncology indications and markets Gelclair(R) for the relief ... Free with registration - Business Wire - AccessMyLibrary.com

Drug Development; American Pharmaceutical Partners receives US FDA …  -  May 11, 2006
...(FDA) for its Abbreviated New Drug Application (ANDA) for Mitoxantrone Injection, USP (Concentrate), the generic equivalent of Serono Labs' Novantrone. ... Pay-Per-View - Biotech Business Week - Factiva, from Dow Jones

Common MS Drug Shows Promise for Aggressive Disease, Say …  -  May 6, 2005
While on Novantrone alone, the investigators had discovered six relapses in the ... For instance, in his practice, Boggild says Novantrone is typically ... MS Neighborhood

MEDICAL EDGE: ASK THE MAYO CLINIC.(Life and Arts) | Article from …  -  May 19, 2008
She is now taking Novantrone, a chemotherapy drug and immune suppressor, ... The medication your daughter is taking, Novantrone, works to suppress the ... Pay-Per-View - Seattle Post-Intelligencer - HighBeam Research

Merger and Acquisition Scenario  -  Nov 22, 2008
Tarceva (Erlotinib); Novantrone (Mitoxantrone Hydrochloride); OSI-930 (c-kit/VEGFR-2 ... Novantrone (Mitoxantrone Hydrochloride). Oncology. Breast Cancer. $250.00 - Revere Reports - Revere

OSI Pharmaceuticals Einstiegschance  -  Jun 23, 2005
Mit Gelcair und Novantrone hätten sich zwei weitere Medikamente in der aktuellen Krebstherapie etabliert und vier weitere experimentelle Krebs-Wirkstoffe ... AktienCheck

Merger and Acquisition Scenario  -  Apr 7, 2007
Novantrone (Mitoxantrone Hydrochloride). Psychiatric Disorders. Childhood/Adolescent Disorders. Attention Deficit Disorder (ADD)/Attention Deficit ... $250.00 - Revere Reports - Revere

From Multiple Sclerosis, a Multiplicity of Challenges  -  Mar 4, 2008
These are Avonex, Betaseron, Copaxone, Novantrone, Tysabri and Rebif. ... Novantrone is an immunosuppressive cancer drug used to treat progressive MS. ... New York Times

Safety and Tolerability of Mitoxantrone for Worsening Multiple...  -  Oct 2, 2006
Dr. Fox reported data on 509 patients in the RENEW trial who initiated Novantrone 12 mg/m 2 . Patients were excluded from the study if they showed signs of ... DG News

FDA first-time generics approvals--2006.(Special Report)(Statistical...  -  Feb 19, 2007
5 mg and 7.5mg APRIL Mitoxantrone injectionAmerican Pharmaceutical Novantrone USP (concentrate),Partners Inc.injection 2 mg/ml, packaged in 20 mg/10 ml, ... Pay-Per-View - Chain Drug Review - HighBeam Research

Merger and Acquisition Scenario  -  Feb 10, 2007
Novantrone (Mitoxantrone Hydrochloride). Psychiatric Disorders. Childhood/Adolescent Disorders. Attention Deficit Disorder (ADD)/Attention Deficit ... $250.00 - Revere Reports - Revere

Happening now: bulletins from clinical trials of new MS therapies.( …  -  Jun 1, 2007
Mitoxantrone (Novantrone) was approved for people with some worsening forms of MS in ... Copaxone and Novantrone: Teva Neuroscience, which makes Copaxone, ... $4.95 - Inside MS - ECNext

The many mysteries of multiple sclerosis | Article from International...  -  Mar 6, 2008
These are Avonex, Betaseron, Copaxane, Novantrone and Rebif. ... Novantrone is an immunosuppressive cancer drug used to treat progressive MS. ... Pay-Per-View - International Herald Tribune - HighBeam Research

Arkansas Regulations - 272.113 Chemotherapy Drugs Restricted by …  -  Apr 2, 2008
Promethazine Vial 50mg J9293 Z1843 Novantrone (Metoxantron HCL) 20mg J9293 Z1844 Novantrone (Metoxantron HCL) 25mg J9293 Z1845 Novantrone (Metoxantron ... Pay-Per-View - Arkansas Regulations - Loislaw

MS Guessing Game Heats Up  -  Mar 9, 2006
Novantrone is the only MS drug with annual sales below $1 billion. Assuming the Food and Drug Administration supports its panel's recommendation, ... TheStreet.com - TheStreet.com (subscription)

Merger and Acquisition Scenario  -  Nov 29, 2008
Buyer Products:. Novantrone (Mitoxantrone Hydrochloride). Restless Leg Syndrome. Gamma-Aminobutyric Acid (GABA) Reuptake Inhibitors. $250.00 - Revere Reports - Revere

Press Release: Dendreon's PROVENGE Granted FDA Priority Review for …  -  Jan 16, 2007
Article: FDA Advisory Committee Says Chemotherapy Drug Novantrone Offers ... ... Novantrone for late stage prostate cancer patients, many of ... ... Pay-Per-View - PR Newswire - HighBeam Research

Q3 2005 OSI Pharmaceuticals, Inc. Earnings Conference Call - Part 2.  -  Nov 1, 2005
COLIN GODDARD: Let's just talk generally to the Novantrone situation, ... Net/net to that, to us, Novantrone will in essence be a nonevent as it goes ... Free with registration - America's Intelligence Wire - AccessMyLibrary.com

Radio-Immunotherapy with Zevalin®: Updates from the 2006 American …  -  Dec 9, 2006
Researchers from Italy evaluated Zevalin consolidation therapy after induction therapy with oral Fludara and Novantrone (FM) in 62 previously untreated ... Cancer Consultants

Business of Life  -  Mar 18, 2008
It is meant to protect the myelin from an immunological attack. novantrone is an immunosuppressive cancer drug used to treat progressive MS. ... Livemint

Multiple Sclerosis (MS) - Medications  -  Feb 28, 2008
Betaseron and Novantrone may delay disease progression in some people with secondary progressive MS. Currently, there is no effective disease-modifying ... WebMD

DMT Co Ltd acquires Good Cell Life Inc - Feb 22, 2006 - Deal Snapshot...  -  Feb 22, 2006
PATIENTS RECEIVING DMT (%) OTHER DMT THERAPY REGIMEN DMT TOTAL NOVANTRONE (MITOXANTRONE) MONOTHERAPY COPAXONE…### (##.#%) PATIENTS RECEIVING DMT (%) OTHER ... Pay-Per-View - deals - Alacra Store

Loislaw Federal District Court Opinions - ALLERGAN, INC. v. …  -  Jan 19, 2005
Id. While the administrative record here does not address Novantrone further, Allergan also submits a November 8, 1991, letter from Parke-Davis, ... Pay-Per-View - Loislaw Federal District Court Opinions - Loislaw

Survival hope for patients with metastatic prostate cancer  -  Mar 4, 2007
A Phase III clinical trial named TAX 327 compared Taxotere plus prednisone to Novantrone (mitoxantrone) plus prednisone. The study included a little over a ... TopCancerNews.com

Facts on Multiple Sclerosis  -  Mar 3, 2005
Meanwhile, Novantrone, commercialized in the US by Serono, is recommended for use in the aggressive relapsing form of the disease and for patients not ... Subscription - Wall Street Journal Online - Dow Jones & Company

Merger and Acquisition Scenario  -  Jan 27, 2007
PSN357 (Glycogen Phosphlorylase Inhibitor); PSN105/PSN010 (Glucokinase Activators); PSN9301 (Dipeptidyl Peptidase-IV Inhibitor); Novantrone (Mitoxantrone ... $250.00 - Revere Reports - Revere

Press Release: Dendreon Announces FDA Advisory Committee …  -  Mar 29, 2007
The committee ... treatment in late stage prostate cancer patients. The supplemental ... Novantrone for late stage prostate cancer patients, many of whom . ... Pay-Per-View - PR Newswire - HighBeam Research

OSI Pharmaceuticals Announces Third Quarter 2006 Financial Results.  -  Nov 6, 2006
Partially offsetting these increases was a decline in maintenance fees for Novantrone[R]. On an adjusted basis, operating expenses were $87.3 million for ... Free with registration - Business Wire - AccessMyLibrary.com

La esclerosis múltiple  -  Mar 10, 2008
Estamos hablando de Avonex, Betaseron, Copaxane, Novantrone y Rebif. ... Novantrone, en tanto, es un fármaco inmunosupresor para combatir el cáncer, ... La Prensa - La Prensa (Panamá)

Q3 2005 OSI Pharmaceuticals, Inc. Earnings Conference Call - Part 1.  -  Nov 1, 2005
Novantrone commission revenue declined from a year ago. Novantrone is approaching the end of its patent life and will have a diminished impact on the ... Free with registration - America's Intelligence Wire - AccessMyLibrary.com

OSI Pharmaceuticals Announces First Quarter 2006 Financial Results.  -  May 8, 2006
...--Sales commissions of $7.1 million related to oncology sales of Novantrone. As previously communicated, future commissions are expected to decline as a ... Free with registration - Business Wire - AccessMyLibrary.com

Merger and Acquisition Scenario  -  May 17, 2008
Tarceva (Erlotinib); Novantrone (Mitoxantrone Hydrochloride); OSI632/Formerly CP 547632 (VEGFR Inhibitor); Avastin (Bevacizumab)/Tarceva (Erlotinib HCl) ... $250.00 - Revere Reports - Revere

Event Brief of Q4 2005 OSI Pharmaceuticals, Inc. Earnings Conference ...  -  Mar 8, 2006
Sales commissions from the promotion of Novantrone totaled $8m for 4Q05 as the Co. saw a continued decline in Novantrone sales as it approaches the end of ... Free with registration - Fair Disclosure Wire - AccessMyLibrary.com

Merger and Acquisition Scenario  -  Jul 12, 2008
Novantrone (Mitoxantrone Hydrochloride). Phase I/Phase II Clinical Stage Products. Therapeutics that are being investigated for the treatment of immune ... $250.00 - Revere Reports - Revere

Bits with a benefit  -  Apr 11, 2005
In addition to physical therapy, Scrivener takes several medications, including Novantrone, an intravenous medication administered every three months. ... Herald-Mail - The Herald-Mail

American Pharmaceutical Partners Adds to Its Broad Oncology Portfolio...  -  Apr 11, 2006
...with the Securities and Exchange Commission. NOVANTRONE(R) is a registered trademark of Immunex Corporation. This product is now marketed by Serono, Inc. RedOrbit

Event Brief of Q4 2004 OSI Pharmaceuticals, Inc. Earnings Conference ...  -  Feb 8, 2005
...s rights to Novantrone and is lower from last year due to the write-off from Gelclair taken at the end of last year. 6. Investment income was higher due to ... Free with registration - America's Intelligence Wire - AccessMyLibrary.com

Teva Gets Approval for Serono Generic  -  Apr 13, 2006
The product is the AP-rated equivalent to Novantrone Injection produced by the Swiss biotech Serono. The product generated annual sales of approximately $75 ... RedOrbit

Serono drug draws FDA warning on heart risk  -  May 24, 2005
Patients taking Novantrone can experience congestive heart failure during therapy or even years after therapy is completed. The drug was approved by the FDA ... FierceBiotech

Q2 2005 OSI Pharmaceuticals, Inc. Earnings Conference Call - Final.  -  Jul 28, 2005
With respect to commissions from sales of Novantrone, this quarter saw a decrease from a year ago likely driven in part by the changing reimbursement ... Free with registration - Fair Disclosure Wire - AccessMyLibrary.com

ASCO 2006: Advances in the Treatment of Chronic Lymphocytic …  -  Jun 2, 2006
Also presented at ASCO were the results of a phase II study of adding Novantrone® (mitoxantrone) to FCR (FCM-R) in patients with untreated CLL who were less ... Cancer Consultants

Company Profile Report  -  Mar 29, 2008
Merck Serono Novantrone (Mitoxantrone Hydrochloride). Phase I/Phase II Clinical Stage Products ... Merck Serono Novantrone (Mitoxantrone Hydrochloride) ... $50.00 - Revere Reports - Revere

Merger and Acquisition Scenario  -  Aug 2, 2008
PSN010 (Glucokinase Activators); PSN357 (Glycogen Phosphlorylase Inhibitor); PSN821 (G-Protein Coupled Receptor 119) Agonist; Novantrone (Mitoxantrone ... $250.00 - Revere Reports - Revere

Merger and Acquisition Scenario  -  Dec 27, 2008
PSN010 (Glucokinase Activators); PSN357 (Glycogen Phosphlorylase Inhibitor); PSN821 (G-Protein Coupled Receptor 119) Agonist; Novantrone (Mitoxantrone ... $250.00 - Revere Reports - Revere

Press Release: Research and Markets: Keep Up-to-Date with the Latest ...  -  May 18, 2005
Article: FDA Approves Novantrone, First Chemotherapy Drug for Advanced ... PR Newswire; November 13, 1996 ; 700+ words ... ... pain related to hormone ... Pay-Per-View - PR Newswire - HighBeam Research

OSI Pharmaceuticals Inc  -  Jun 19, 2006
OSIP markets and promotes Novantrone for approved oncology indications in the ... Novantrone is an anthracenedione used. as an intravenous chemotherapy agent. $35.00 - Stock Reports - Standard & Poor's

Xanthus Presents Symadex Gene Expression Study at AACR; -- …  -  Apr 18, 2005
Note: Novantrone(R) is a registered trademark of Serono, Inc. and OSI Pharmaceuticals, Inc. CONTACT: Kari Lampka of MacDougall Biomedical Communications, ... $4.95 - PR Newswire - ECNext

Merger and Acquisition Scenario  -  Mar 8, 2008
Tarceva (Erlotinib); Novantrone (Mitoxantrone Hydrochloride); OSI-930 (c-kit/VEGFR-2 Inhibitor); Avastin (Bevacizumab)/Tarceva (Erlotinib HCl) ... $250.00 - Revere Reports - Revere

Merger and Acquisition Scenario  -  May 31, 2008
Novantrone (Mitoxantrone Hydrochloride). Phase I/Phase II Clinical Stage Products. Therapeutics that are being investigated for the treatment of immune ... $250.00 - Revere Reports - Revere

Merger and Acquisition Scenario  -  Jan 26, 2008
Novantrone (Mitoxantrone Hydrochloride). Oncology. Digestive System. Colon Cancer/Colorectal Cancer. Metastatic. Epidermal Growth Factor Receptor Tyrosine ... $250.00 - Revere Reports - Revere

Multiple mysteries  -  Mar 13, 2008
These are Avonex, Betaseron, Copaxone, Novantrone and Rebif. ... Novantrone is an immunosuppressive cancer drug used to treat progressive MS. ... $2.95 - Daily Reflector - NewsBank

Merger and Acquisition Scenario  -  May 20, 2006
Novantrone (Mitoxantrone Hydrochloride). Phase I/Phase II Clinical Stage Products ... Novantrone (Mitoxantrone Hydrochloride). Oncology. Digestive System ... $250.00 - Revere Reports - Revere

Company Profile Report  -  Mar 1, 2008
Novantrone (Mitoxantrone Hydrochloride). Phase I/Phase II Clinical Stage ... Novantrone (Mitoxantrone Hydrochloride). Phase I/Phase II Clinical Stage ... $50.00 - Revere Reports - Revere

Press Release: ORENCIA(R) (abatacept) or REMICADE(R)(infliximab) …  -  Nov 14, 2006
Avonex Betaseron Rebif Copaxone Novantrone - ABT 874 Rituxan Campath Zenapax - MLN1202 Remicade Enbrel Kineret Orencia Rituxan Remicade Enbrel Humira ... Pay-Per-View - PR Newswire - HighBeam Research

Press Release: DC Denies Prostate Cancer Vaccine, Provenge: …  -  Jul 30, 2007
Article: FDA Advisory Committee Says Chemotherapy Drug Novantrone ... ... Novantrone for late stage prostate cancer patients, many ... of advanced stage ... Pay-Per-View - PR Newswire - HighBeam Research

Article: Art gallery donates to MS cause - Deseret News (Salt Lake...  -  Jun 7, 2005
Article: Novantrone approved to treat MS progression.(multiple ... Inside MS; January 1, 2001 ; 700+ words ... ... lt;www.immunex.comp>. ... Pay-Per-View - Deseret News - HighBeam Research

Article: nation at a glance.(Front) - The Virginian Pilot | HighBeam ...  -  Oct 29, 2008
Article: FDA Advisory Committee Says Chemotherapy Drug Novantrone ... ... Novantrone for late stage prostate cancer patients, many ... of advanced stage ... Pay-Per-View - Virginian-Pilot - HighBeam Research

Article: Faculty Priorities Reconsidered: Rewarding Multiple Forms of...  -  Nov 1, 2007
Article: NOVANTRONE(R) One Step Closer to FDA Approval to Treat ... ... Approvable Letter' in Support Of NOVANTRONE(R) to Treat Multiple Forms of Multiple ... Pay-Per-View - Journal of Higher Education - HighBeam Research

Press Release: Spectrum Pharmaceuticals Announces Completion of …  -  Feb 16, 2007
Article: FDA Advisory Committee Says Chemotherapy Drug Novantrone ... ... Novantrone for late stage prostate cancer patients, many ... of advanced stage ... Pay-Per-View - PR Newswire - HighBeam Research

American Pharma, Emulex, Rail America set to move - MarketWatch  -  Apr 12, 2006
...the generic equivalent of Serono SA's Novantrone. The drug, in combination with corticosteroids, is indicated as initial chemotherapy for patients with ... MarketWatch

Press Release: Dendreon Receives Complete Response Letter From …  -  May 9, 2007
Article: FDA Advisory Committee Says Chemotherapy Drug Novantrone ... ... Novantrone for late stage prostate cancer patients, many ... of advanced stage ... Pay-Per-View - PR Newswire - HighBeam Research

AFX Europe Summary - midday  -  May 25, 2005
...with gains in heavyweight Novartis offset by a weak financial sector and Serono down on news regarding health risks associated with MS drug Novantrone, ... Forbes

Serono Q2 net profit rises 8 pct, sales disappoint - UPDATE  -  Jul 27, 2006
0.4 pct to 53.8 mln, sales for dermatology drug Raptiva surging by 130.4 pct to 17.3 mln and sales in oncology drug Novantrone down 70.4 pct at 5.4 mln. Forbes

Abilify gets priority review.(Digest)(Brief article) | Article from...  -  Aug 20, 2007
Article: Novantrone granted priority review. ... Novantrone, a treatment for multiple sclerosis, has been granted priority review by the FDA. ... Pay-Per-View - Chain Drug Review - HighBeam Research

'I'm Not a Sick Person' - Multiple Sclerosis: New Hope for Patients  -  Mar 14, 2006
Another drug, Novantrone, has also been approved for people with a rapidly worsening form of MS. A chemotherapy drug, it's given intravenously and also ... $2.95 - Newsweek - NewsBank

Patient, heal thyself  -  Nov 6, 2005
Another drug, Copaxone, helps block damaging immune cell attacks, and Novantrone, a low-dose chemotherapy, helps reduce the frequency of attacks. ... Pay-Per-View - Chicago Tribune - ProQuest Archiver

Cycling champ returns to racing after battle with MS  -  Sep 9, 2005
At the time, there were no drug therapies for MS; now there are five — Avonex, Betaseron, Copaxone, Novantrone and Rebif. All aim to slow the effects of the ... Seattle Times

Granulocytic sarcoma and subsequent acute leukemia recurrence with …  -  Mar 20, 2006
The patient was treated with new induction scheme (FLANG: fludarabine 10 mg/m 2 daily on days 1–3; cytarabine 1000 mg/m 2 daily on days 1–3 and novantrone ... Nature.com

A systematic review of the effectiveness of docetaxel and mitoxantrone...  -  Apr 28, 2006
A scoping search was conducted which identified a trial of docetaxel plus prednisone vs mitoxantrone (Novantrone ® , Wyeth, Maidenhead, UK) plus prednisone ... Nature.com

Multiple Sclerosis (MS) - Medications  -  Feb 28, 2008
Mitoxantrone (Novantrone) for relapsing-remitting MS that is rapidly getting worse or when other medicines for MS have not worked. Natalizumab (Tysabri). ... WebMD

FDA okays Teva prostate cancer drug  -  Apr 14, 2006
Teva said it will immediately begin shipping the drug, which is the AP-rated equivalent of Serono's Novantrone Injection. Separately, Teva said it expected ... Jerusalem Post

ALTERNATIVE MEDICINE.(Life and Arts) | Article from Seattle Post- …  -  Apr 12, 2007
Immunex is seeking permission to market Novantrone for the secondary progressive form of MS, a more advanced type of the disease than the ... Pay-Per-View - Seattle Post-Intelligencer - HighBeam Research

Moreno Valley | PE.com | Southern California News | News for Inland …  -  Mar 2, 2005
2000 - Novantrone approved in US for worsening forms of MS. 2001 - MS Society Task Force develops first new diagnosis criteria for MS in 20 years. ... Press-Enterprise

Pivotal Phase III Tarceva Study Published in the New England Journal...  -  Jul 13, 2005
In addition to Tarceva, (OSI) Oncology exclusively markets Novantrone(R) (mitoxantrone concentrate for injection) for its approved oncology indications and ... RedOrbit

MEDICAL EDGE, MS drugs haven't proven effective  -  Mar 28, 2006
Interferon beta- 1b (Betaseron), interferon beta-1a (Avonex, Rebif), glatiramer (Copaxone) and mitoxantrone (Novantrone) are only partially effective in the ... Pay-Per-View - Newsday - ProQuest Archiver

FACES OF HOPE Riding to fight multiple sclerosis Bicycle team co- …  -  Sep 7, 2008
Cancer drug OK'd for multiple sclerosis Novantrone may help those ... with crippling late-stage multiple sclerosis. An estimated 350000 ... immunex.com ... Pay-Per-View - Milwaukee Journal Sentinel - HighBeam Research

Placeway, Bonnie S. | Article from The Milwaukee Journal Sentinel | …  -  Nov 10, 2005
Cancer drug OK'd for multiple sclerosis Novantrone may help those ... with crippling late-stage multiple sclerosis. An estimated 350000 ... immunex.com ... Pay-Per-View - Milwaukee Journal Sentinel - HighBeam Research

Drug program to help uninsured | Article from The Milwaukee Journal …  -  Jul 6, 2005
Cancer drug OK'd for multiple sclerosis Novantrone may help those with late-stage ... Washington -- The government gave its approval Friday for doctors to ... Pay-Per-View - Milwaukee Journal Sentinel - HighBeam Research

FDA okays Teva prostate cancer drug | Article from Jerusalem Post | …  -  Apr 14, 2006
Teva said it will immediately begin shipping the drug, which is the AP-rated equivalent of Serono's Novantrone Injection. Separately, Teva said it expected ... Pay-Per-View - Jerusalem Post - HighBeam Research

Westhauser, Roslyn L. "Rosie" | Article from The Milwaukee Journal …  -  Aug 14, 2006
Cancer drug OK'd for multiple sclerosis Novantrone may help those ... with crippling late-stage multiple sclerosis. An estimated 350000 ... immunex.com ... Pay-Per-View - Milwaukee Journal Sentinel - HighBeam Research

Westhauser, Roslyn L. "Rosie" | Article from The Milwaukee Journal …  -  Aug 13, 2006
Cancer drug OK'd for multiple sclerosis Novantrone may help those ... with crippling late-stage multiple sclerosis. An estimated 350000 ... immunex.com ... Pay-Per-View - Milwaukee Journal Sentinel - HighBeam Research

Article: Mueller, Allan L. Atty. - The Milwaukee Journal Sentinel | …  -  Feb 20, 2005
Cancer drug OK'd for multiple sclerosis Novantrone may help those ... with crippling late-stage multiple sclerosis. An estimated 350000 ... immunex.com ... Pay-Per-View - Milwaukee Journal Sentinel - HighBeam Research

Seiler, James J. | Article from The Milwaukee Journal Sentinel | …  -  Aug 1, 2006
Cancer drug OK'd for multiple sclerosis Novantrone may help those ... with crippling late-stage multiple sclerosis. An estimated 350000 ... immunex.com ... Pay-Per-View - Milwaukee Journal Sentinel - HighBeam Research

Brand Names/Synonyms:
Novantrone is also known by the following brand names and/or synonymsCCRIS 7604; CHEMBANK1135; DHAD; DHAQ; Dhaq Hcl; Dihydroxyanthraquinone; Immunex; M6545; Mitox; Mitoxanthrone; Mitoxantron; Mitoxantrona [Inn-Spanish]; Mitoxantrone; Mitoxantrone 2hcl; Mitoxantrone Dihydrochloride; Mitoxantrone Hcl; Mitoxantrone Hydrochloride; Mitoxantronum [Inn-Latin]; Mitozantrone; Mitozantrone Hydrochloride; Novantron; Novantrone

Drug Category:
Novantrone is categorized under the following by the FDA: Antineoplastic Agents; Analgesics; ATC:L01DB07

Dosage Forms:
Solution

Absorption:
poor (oral)

Interactions:
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Chemical IUPAC Name:
1,4-dihydroxy-5,8-bis[2-(2-hydroxyethylamino)ethylamino]-anthracene-9,10-dione





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