Ofloxacin

This page contains recent news articles, when available, and an overview of Ofloxacin but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Ofloxacin
(when available)

Pharmacology and use:
Ofloxacin is a quinolone/fluoroquinolone antibiotic. Ofloxacin is bactericidal and its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase, which allows the untwisting required to replicate one DNA double helix into two. Notably the drug has 100 times higher affinity for bacterial DNA gyrase than for mammalian. Ofloxacin is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria. For the treatment of infections (respiratory tract, kidney, skin, soft tissue, UTI), urethral and cervical gonorrhoea

Mechanism Of Action:
Ofloxacin, acts on DNA gyrase, an enzyme which, like human topoisomerase, prevents the excessive supercoiling of DNA during replication or transcription.

News Articles on Ofloxacin

Risk of Endophthalmitis After Intravitreal Drug Injection When Topical ...  -  ‎Dec 14, 2009‎
Ta CN, Egbert PR, Singh K, Shriver EM, Blumenkranz MS, Miño de Kaspar H. Prospective randomized comparison of 3-day versus 1-hour preoperative ofloxacin ... Archives of Ophthalmology

Karnataka DC seizes stocks of Ofloxacin tablets valued at Rs 1.20 lakh  -  ‎Oct 20, 2009‎
Karnataka Drugs Control department has seized a stock of Ofloxacin tablets valued at Rs 1,20540. The stock tablets is found to be not-of-standard quality. ... pharmabiz.com

Venus Remedies moves north after bagging patent rights in South Africa  -  ‎Nov 11, 2009‎
...of India (DCGI) after conducting a triple arm Phase III comparative clinical trial study of the drug against ofloxacin and metronidazole therapies. ... India Infoline.com

What are Gonococcal Infections?  -  ‎Oct 18, 2009‎
These include cefixime, ceftriaxone, ciprofloxacin, and ofloxacin. Doxycycline might be added to treat Chlamydia trachomatis, a disease which commonly ... 24 Medica

Phát hiện thuốc kháng sinh Ofloxacin giả  -  ‎Oct 20, 2009‎
Ä?ây là thuốc giả, không chứa hoạt chất Ofloxacin. Theo ông Nguyá»…n Văn Thanh - Phó Cục trưởng Cục QLD, các sản phẩm thuốc trên nhãn có ghi: Mission Pharma ... Thanh Niên

Phát hiện thuốc kháng sinh giả  -  ‎Oct 31, 2009‎
Ä?ồng thá»?i, các cÆ¡ quan chức năng phải phối hợp kiểm tra, kịp thá»?i phát hiện, ngăn chặn nhập khẩu và truy tìm nguồn gốc xuất xứ thuốc Ofloxacin giả này./. Đài Tiếng Nói Việt Nam

Ä?ình chỉ lưu hành thuốc không đạt tiêu chuẩn chất lượng  -  ‎Oct 19, 2009‎
Ngoài ra, Sở Y tế cũng đ� nghị các đơn vị tăng cư�ng phòng, chống thuốc OFLOXACIN giả, vì hiện nay trên thị trư�ng đã xuất hiện thuốc OFLOXACIN giả, ... Khanh Hoa

Un río de medicamentos  -  ‎Nov 5, 2009‎
...el ibuprofeno, elemento base en muchos antiinflamatorios; el ácido clofíbrico, utilizado para reducir el colesterol, y el Ofloxacin, un antibiótico, ... El País (España)

Kasus Resistensi Obat Berpotensi Naik  -  ‎Oct 19, 2009‎
Jika gagal, pasien harus menjalani pengobatan lini kedua, kamamycin dan ofloxacin, 2 tahun berturut-turut. Juga ditemukan RS mengombinasi obat lini pertama ... KOMPAS.com

Ba phương án triển khai kế hoạch sá»­ dụng vaccine cúm A (H1N1)  -  ‎Oct 22, 2009‎
Cục Quản lý Dược (Bá»™ Y tế) vừa có văn bản gá»­i Sở Y tế các tỉnh, thành phố thông báo vá»? việc phát hiện thuốc Ofloxacin giả xuất hiện trên thị trưá»?ng. ... Báo điện tử Sơn La

Ngừa bệnh tiêu hóa hay gặp sau bão lụt  -  ‎Oct 25, 2009‎
...nay phải sá»­ dụng các thuốc chưa bị kháng, được khuyên dùng như: ampicilin, ciprofloxacin, ofloxacin... chống mất nước bằng uống oresol và truyá»?n dịch. ... Báo Hoà Bình

Akorn gets FDA approval for Ofloxacin Ophthalmic Solution  -  Apr 16, 2008
BOSTON (Thomson Financial) - Akorn Inc. Wednesday said it received approval from the Food and Drug Administration for its abbreviated new drug application ... Forbes

Does ofloxacin protect against BCG-related toxic effects in patients...  -  Dec 11, 2006
Colombel M et al. (2006) The effect of ofloxacin on Bacillus Calmette–Guerin induced toxicity in patients with superficial bladder cancer: results of a ... Nature.com

[U] Daiichi Sankyo Co., Ltd. v. Apotex, Inc., No. 2006-1564 (Fed....  -  Jul 11, 2007
The '741 patent is drawn to a method for treating bacterial ear infections by topically administering the antibiotic ofloxacin into the ear. ... $2.95 - U.S. Court of Appeals, Federal Circuit - VersusLaw

India's FDC says gets US FDA approval for glaucoma treatment drug  -  May 9, 2008
In a regulatory filing with the Bombay Stock Exchange, FDC said its other two ANDAs, Ciprofloxacin Ophthalmic Solution and Ofloxacin Solution, are in final ... Forbes

Apotex Receives Final Approval for Ofloxacin Otic 0.3%  -  Nov 30, 2005
Apotex Corp. today announced that it has received final approval from the US Food and Drug Administration (FDA) for its Abbreviated New Drug Application ... RedOrbit

… of single intravenous bolus dose of ofloxacin in calves.(Research...  -  Sep 1, 2006
The synthetic bactericidal agents, fluoroquinolones, have revolutionised treatment both in human and veterinary medicine. They are effective against ... Free with registration - Indian Journal of Pharmacology - AccessMyLibrary.com

Ofloxacin-induced reversible arthropathy in a child.(Letters)  -  Apr 1, 2007
Ofloxacin, a potent fluoroquinolone antibiotic, is used in various gram-positive and gram-negative bacterial infections. Common adverse drug reactions (ADR) ... Free with registration - Journal of Postgraduate Medicine - AccessMyLibrary.com

Ofloxacin (Otic).(Drug overview)  -  May 1, 2006
Ofloxacin ( oh-FLOX-a-sin) belongs to the family of medicines called antibiotics. Ofloxacin otic solution is used to treat infections of the ear canal. ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Learn about Ofloxacin Otic from Consumer Reports Health.  -  Jan 4, 2007
Ofloxacin otic is used to treat outer ear infections in adults and children, chronic (long-lasting) middle ear infections in adults and children with a ... consumerreports.org

FDC gets approval for Ciprofloxacin solution  -  Jul 2, 2008
The Company had recently received approval for Timolol Maleate Ophthalmic Solution. Another ANDA ofloxacin ophthalmic solution is in the final stages of ... Business Standard

Prices of 70 drugs may be raised  -  Jul 28, 2008
Over the past few months, the price of bulk raw materials that go into the making of antibiotics like ciprofloxacin and ofloxacin have gone up steeply. ... Rediff

Eastern Cape is giving XDR-TB drugs  -  Feb 13, 2007
The other drugs being used in the fight against the diseases are: Amikacin, Kanamycin, Ofloxacin, and Dapsone. The department also denied reports of at ... Independent Online

… , Inc. Announces FDA Approval Of Ofloxacin Ophthalmic Solution USP,...  -  Apr 18, 2008
Akorn, Inc. (NASDAQ:AKRX) announced that the US Food and Drug Administration (FDA) has granted approval for Akorn's Abbreviated New Drug Application (ANDA) ... Medical News Today - Medical News Today (press release)

Taking Ofloxacin Otic from Consumer Reports Health.  -  Jan 4, 2007
Ofloxacin otic may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:. Some side effects can be serious. ... consumerreports.org

… .(Ciprofloxacin Ophthalmic Solution, Ofloxacin Ophthalmic Solution...  -  May 2, 2005
...two new ophthalmic products, Ciprofloxacin Ophthalmic Solution (ciprofloxacin) 0.3% and Ofloxacin Ophthalmic Solution (ofloxacin) 0.3%, in the USA. ... $4.95 - Pharma Marketletter - ECNext

Drug Resistance; Ciprofloxacin, ofloxacin, and levofloxacin have...  -  Jan 2, 2006
2006 JAN 2 - (NewsRx.com) -- Ciprofloxacin, ofloxacin, and levofloxacin have potent in vitro activity against Mycobacterium tuberculosis. ... Pay-Per-View - Anti-Infectives Week - Factiva, from Dow Jones

The Effect Of Ofloxacin On Bacillus Calmette-Guerin Induced Toxicity...  -  May 20, 2007
UroToday.com- BCG immunotherapy is the current 'gold standard' for treatment of non-muscle invasive bladder cancer. It is the only therapy which has been ... Medical News Today - Medical News Today (press release)

Never Had to do it because of insurance Don't need it Yes, I test...  -  May 16, 2008
Ofloxacin interferes with the reproduction of bacterial DNA. Available as: ofloxacin is available as tablets, injection and as drops. What does it do? ... Health24.com

OFLOXACIN (Ophthalmic route) - oh-FLOX-a-sin.(Drug overview)  -  May 1, 2007
Ofloxacin is an antibiotic used to treat bacterial infections of the eye, such as conjunctivitis and corneal ulcers. Ofloxacin is available only with your ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Hi-Tech Pharmacal Receives Final Approval for Ofloxacin Otic Solution  -  Mar 18, 2008
Hi-Tech Pharmacal Co., Inc. (NASDAQ: HITK) announced today that the US Food and Drug Administration (FDA) has granted final approval to the Company's ... RedOrbit

DR REDDY'S GETS USFDA APPROVAL TO MARKET OFLOXACIN …  -  Feb 24, 2006
NEW DELHI, Feb 24 Asia Pulse - Dr Reddy's Laboratories (BSE:500124) has obtained the approval of Food and Drug Administration to sell its antibiotic ... $4.95 - AsiaPulse News - ECNext

OFLOXACIN (Otic route) - oh-FLOX-a-sin.(Drug overview)  -  May 1, 2007
Ofloxacin belongs to the family of medicines called antibiotics. Ofloxacin otic solution is used to treat infections of the ear canal. ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Hi-Tech Granted Approval for Ofloxacin Otic Solution  -  Mar 19, 2008
Hi-Tech Pharmacal has announced that the FDA has granted final approval to the company's abbreviated new drug application for ofloxacin otic solution, 0.3%. ... RedOrbit

Daiichi Sankyo Co., Ltd. v. Apotex, Inc., No. 2006-1564 (Fed. Cir....  -  Sep 12, 2007
The '741 patent is drawn to a method for treating bacterial ear infections by topically administering the antibiotic ofloxacin into the ear. ... $2.95 - U.S. Court of Appeals, Federal Circuit - VersusLaw

Loislaw Federal District Court Opinions - DAIICHI PHARMACEUTICAL …  -  Aug 8, 2005
Claim 4: The method of claim 2 wherein the concentration of ofloxacin in the ... Arguing that Apotex' Ofloxacin Otic Solution is a generic "copy" of its ... Pay-Per-View - Loislaw Federal District Court Opinions - Loislaw

[U] Ortho-McNeil Pharmaceutical Inc. v. Teva Pharmaceuticals USA, No....  -  Mar 17, 2006
Defendants allege that the applicants acted inequitably by representing to the PTO that levofloxacin was surprisingly less toxic than ofloxacin in an effort ... $2.95 - U.S. District Court, District of New... - VersusLaw

Sonic与Yahooå?ˆä½œè‚¡ä»·æ¶¨10% Napsterè·Œ3%  -  May 12, 2005
...制�公�Hi-Tech Pharmacal盘�表示,美国食��物管�局(FDA)暂时批准其新�Ofloxacin 滴耳液的上市申请,用于治疗耳朵的细�感染。其疗效与去年�收达7700万美元 ... 网易

Article: The effect of natural sunlight on ciprofloxacin ophthalmic...  -  Oct 1, 2005
Ciprofloxacin and ofloxacin are recognized as being safe to use, ... With ofloxacin and levofloxacin, the zone size for the control solution was ... Pay-Per-View - Journal of the Mississippi Academy of... - HighBeam Research

Abstract and Introduction  -  Nov 4, 2005
...[2] Based on observations from the ofloxacin study, we hypothesized that sex-based differences ... Effect of gender on the pharmacokinetics of ofloxacin. ... Medscape

Loislaw Federal District Court Opinions - DAIICHI PHARMACEUTICAL …  -  Aug 2, 2006
Claim 4: The method of claim 2 wherein the concentration of ofloxacin in the ... [fn8] Daiichi obtained a patent on the compound of ofloxacin, US patent ... Pay-Per-View - Loislaw Federal District Court Opinions - Loislaw

Isolated skin ulcers due to Mycobacterium tuberculosis in a renal...  -  Apr 5, 2007
Ofloxacin, ethambutol and isoniazid are continued for a further 6 months, followed by isoniazid and ethambutol for the next 9 months. ... Nature.com

… , atomic absorption spectrometric and spectrophotometric determinati...  -  Mar 1, 2005
Nalidixic acid, norfloxacin, ciprofloxacin and its hydrochloride are official in both USP XXIV [2] and BP 1998 [3], while ofloxacin is official in USP XXIV ... Free with registration - American Journal of Applied Sciences - AccessMyLibrary.com

Reducing Toxicity in Bladder Cancer Therapy  -  Oct 19, 2006
To investigate whether the tuberculostatic properties of ofloxacin might be ... They were randomized to 9 BCG instillations along with ofloxacin 200 mg or ... Cancerpage.com

Relative value of different fluoroquinolones.  -  Nov 1, 2007
...(Two other quinolones, norfloxacin and lomefloxacin, are used primarily to treat urinary tract and prostate infections, and ofloxacin is another that is ... $4.95 - Ear, Nose and Throat Journal - ECNext

Otitis externa: providing relief while avoiding complications:...  -  Aug 1, 2005
The fluoroquinolones ofloxacin and ciprofloxacin were approved as topical ... In addition, ofloxacin is indicated for otorrhea from the middle ear through ... Pay-Per-View - Journal of Family Practice - Factiva, from Dow Jones

Which UTI therapies are safe and effective during breastfeeding?( …  -  Mar 1, 2007
Quinolones (ciprofloxacin, ofloxacin) are effective and probably compatible with ... The authors categorize nitrofurantoin, ciprofloxacin, and ofloxacin as ... Free with registration - Journal of Family Practice - AccessMyLibrary.com

Otitis externa: providing relief while avoiding complications:...  -  Aug 1, 2005
The fluoroquinolones ofloxacin and ciprofloxacin were approved as topical ... In addition, ofloxacin is indicated for otorrhea from the middle ear through ... $4.95 - Journal of Family Practice - ECNext

Prasco Laboratories Pictures from October 28, 2008 | HighBeam …  -  Oct 28, 2008
Article: Company receives tentative approval for Ofloxacin . ... Hi-Tech's Ofloxacin Ophthalmic Solution USP, 0.3% is the generic equivalent of Allergan's ... Pay-Per-View - AP Images - HighBeam Research

Mycobacterium tuberculosis drug resistance, Abkhazia.(Letters)(Letter...  -  Mar 1, 2005
Resistance to kanamycin and ethionamide was 14.3% and 12.8%, respectively, while resistance to ofloxacin was low (1.5%). Fluoroquinolones have not been ... $4.95 - Emerging Infectious Diseases - ECNext

Article: PediaMed has entered into a US co-promotion agreement for …  -  Apr 1, 2005
Article: Company receives tentative approval for Ofloxacin . ... Hi-Tech's Ofloxacin Ophthalmic Solution USP, 0.3% is the generic equivalent of Allergan's ... Pay-Per-View - Medical Marketing & Media - HighBeam Research

FDA Mandates Black Box Warning for Some Antibiotics  -  Jul 8, 2008
...(marketed as Levaquin); moxifloxacin (marketed as Avelox); norfloxacin (marketed as Noroxin); and ofloxacin (marketed as Floxin and generic ofloxacin). ... Washington Post

The effect of natural sunlight on ciprofloxacin ophthalmic solution...  -  Oct 1, 2005
Ciprofloxacin and ofloxacin are recognized as being safe to use, ... With ofloxacin and levofloxacin, the zone size for the control solution was ... $4.95 - Journal of the Mississippi Academy of... - ECNext

4. Changes made in revising the Model List by section: medicines for...  -  Jan 1, 2007
The review argued that as levofloxacin is the S-isomer of ofloxacin, ... Given some evidence of the higher price of levofloxacin than ofloxacin and ... Free with registration - Technical Report Series - AccessMyLibrary.com

Vitamin A deficiency presenting with microbial keratitis in two...  -  Jun 3, 2005
Hourly by day and two hourly by night ofloxacin 0.3% drops were commenced ... Ofloxacin 0.3% was continued two hourly to the left eye and four hourly to the ... Nature.com

Error In Determining "Person Of Skill In The Art" Results In Reversal...  -  Nov 7, 2007
The Court also noted that the patent described the testing of ofloxacin on animals and that animal testing was traditionally outside the realm of a ... $9.94 - Mondaq Business Briefing - Alacra Store

First-Time Generic Approvals: Phenergan Tablets, Floxin Otic,...  -  Jan 4, 2006
Ofloxacin otic solution is indicated for the treatment of ear infections caused by susceptible strains of designated microorganisms. ... Medscape

Article: Local Focus.(Business) - Daily Herald (Arlington Heights,...  -  Jul 28, 2007
Article: Company receives tentative approval for Ofloxacin . ... Hi-Tech's Ofloxacin Ophthalmic Solution USP, 0.3% is the generic equivalent of Allergan's ... Pay-Per-View - Daily Herald - HighBeam Research

Bacterial resistance to quinolone otic drops is nearly zero.(Report)  -  Nov 1, 2007
For instance, Ohyama et al reported middle ear levels of ofloxacin that ranged ... Ofloxacin otic contains a lesser amount of active antibiotic because the ... $4.95 - Ear, Nose and Throat Journal - ECNext

Management of post-tympanostomy tube otorrhea in children.(post- …  -  Oct 1, 2006
Goldblatt et al showed that topical ofloxacin was more effective than oral amoxicillin/clavulanate when S aureus or P aeruginosa was present (although the ... Free with registration - Ear, Nose and Throat Journal - AccessMyLibrary.com

Levofloxacin (Levaquin) Resistance Seen in Pediatric Pneumococcal …  -  Mar 24, 2008
The 12 cases reported by Dr. von Gottberg were found after screening 19404 isolates (90% of reported cases of invasive disease) for ofloxacin (Floxin) ... MedPage Today

Fluoroquinolone-resistant Salmonella Paratyphi A.(Letters)(Letter to...  -  Jan 1, 2005
On disk diffusion susceptibility testing, the isolate was resistant to nalidixic acid (NA) and to ofloxacin. The MIC of ofloxacin was as high as 256 ... $4.95 - Emerging Infectious Diseases - ECNext

Emerging Drugs for Active Tuberculosis: Emerging Drugs for TB: …  -  Mar 17, 2008
A recent phase II study that substituted gatifloxacin, moxifloxacin, or ofloxacin for ethambutol in the first 2 months of TB treatment and measured effects ... Medscape

Comparative bacteriology of acute and chronic dacryocystitis  -  Jun 29, 2007
Of all antibacterial agents tested, gatifloxacin and ofloxacin showed lowest ... Of all antibacterials tested, gatifloxacin, ofloxacin, and amikacin show ... Nature.com

Penetration of topically applied levofloxacin into eyes with thin...  -  Jul 6, 2005
It is generally twice as potent as ofloxacin when tested in vitro. Levofloxacin is active against most aerobic Gram-positive and Gram-negative organisms and ... Nature.com

Diabetes Complications; Systematic review of diabetic foot ulcer...  -  May 31, 2006
Topical pexiganan cream may be as effective as oral antibiotic treatment with ofloxacin for the resolution of local infection. Ampicillin and sulbactam were ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

Global distribution of Panton-Valentine leukocidin--positive methicill...  -  Apr 1, 2007
Since 2003, new antimicrobial resistance determinants have been acquired (e.g., gentamicin and ofloxacin). One ST8 isolate was resistant to penicillin, ... Free with registration - Emerging Infectious Diseases - AccessMyLibrary.com

The use of systemic fluoroquinolones.(microbial drug resistance)  -  Sep 1, 2006
In a randomized, open-label trial, oral cefixime for 7 days was compared with oral ofloxacin for 5 days in 82 Vietnamese children with culture-proven ... $4.95 - Pediatrics - ECNext

Drug Resistance; MTB gyrase mutations identified as quinolone...  -  Mar 28, 2006
The authors continued, "MICs, enzyme inhibition, and drug-induced DNA cleavage were determined for moxifloxacin, gatifloxacin, ofloxacin, levofloxacin, ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

Loislaw Federal District Court Opinions - ORTHO-MCNEIL …  -  Aug 28, 2008
Specifically, Defendants assert that the active ingredient in Levaquin (covered by the `407 patent) is (+) ofloxacin, which is an active ingredient in ... Pay-Per-View - Loislaw Federal District Court Opinions - Loislaw

Impact of biofilms on the treatment of otitis.(Clinical report)  -  Nov 1, 2007
Topical ciprofloxacin/dexamethasone otic suspension is superior to ofloxacin otic solution in the treatment of children with acute otitis media with ... Free with registration - Ear, Nose and Throat Journal - AccessMyLibrary.com

First-Time Generic Approvals: Metaglip, Zofran ODT, Floxin Otic  -  Nov 29, 2005
18, the FDA approved a first-time generic formulation of ofloxacin 0.3% otic ... Ofloxacin otic solution is indicated for the treatment of otitis externa, ... Medscape

Quinolones for uncomplicated acute cystitis in women  -  Jul 1, 2007
Adverse drug reactions occurred frequently for ofloxacin than levofloxacin. Insomnia was reported more frequently for enoxacin than ciprofloxacin. ... Medscape

Global distribution of Panton-Valentine leukocidin--positive methicill...  -  Apr 1, 2007
Since 2003, new antimicrobial resistance determinants have been acquired (e.g., gentamicin and ofloxacin). One ST8 isolate was resistant to penicillin, ... $4.95 - Emerging Infectious Diseases - ECNext

YMCAs Invite New Swimmers to Splash Into Health and Fun.  -  May 15, 2006
FLOXIN(R) Otic (ofloxacin otic) solution 0.3% is indicated for in the treatment of otitis externa (OE) in adults and pediatric patients, 6 months and older ... $4.95 - PR Newswire - ECNext

Press Release: Progressive Following on Akorn Inc. - M2 Presswire | …  -  Apr 16, 2008
Ofloxacin Ophthalmic Solution is an anti-infective used to treat infections caused by bacteria in conjunctivitis and corneal ulcers. ... Pay-Per-View - M2 Presswire - HighBeam Research

Safety and efficacy of topical quinolones.  -  Oct 1, 2005
Ofloxacin eardrop treatment for active chronic suppurative otitis media: ... 30%) Tong et al, (6) 1996 Ofloxacin marginally superior (cure rates: 89 vs. ... Free with registration - Ear, Nose and Throat Journal - AccessMyLibrary.com

Drug Resistance; MTB gyrase mutations identified as quinolone...  -  Mar 31, 2006
The authors continued, "MICs, enzyme inhibition, and drug-induced DNA cleavage were determined for moxifloxacin, gatifloxacin, ofloxacin, levofloxacin, ... Pay-Per-View - Drug Week - Factiva, from Dow Jones

Clinical Infectious Diseases publishes findings with pexiganan in...  -  Dec 17, 2008
Bacterial resistance to ofloxacin emerged in some patients who received ofloxacin, but no significant resistance to pexiganan emerged among patients who ... $9.94 - M2 Europharma - Alacra Store

Toxicology; Chitosan derivatives staunch genotoxicity  -  Mar 11, 2005
..."It is suggested that different mechanisms may be involved in its protective action-antioxidant activity in case of ofloxacin-induced DNA damage, ... Pay-Per-View - Drug Week - Factiva, from Dow Jones

Toxicology; Chitosan derivatives staunch genotoxicity  -  Mar 7, 2005
..."It is suggested that different mechanisms may be involved in its protective action-antioxidant activity in case of ofloxacin-induced DNA damage, ... Pay-Per-View - Clinical Oncology Week - Factiva, from Dow Jones

Extensively drug-resistant Mycobacterium tuberculosis, India.(LETTERS)...  -  Sep 1, 2007
Resistance to ofloxacin, kanamycin, and ethionamide was determined by a ... MDR strains, which were further resistant to ofloxacin, and to at least 1 of 2 ... $4.95 - Emerging Infectious Diseases - ECNext

Akorn Launches Two New Ophthalmic Drug Products.  -  May 3, 2005
The patents for both Ophthalmic Solution versions of Ciprofloxacin (Ciloxan(R)) and Ofloxacin (Occuflox(R)) have expired, and industry sources indicate the ... $4.95 - Business Wire - ECNext

Article: Antibiotic side effects.(FDA Bits)(Food and drug administrati...  -  Apr 1, 2005
FDA Bits)(Food and drug administration)(Levaquin (levofloxacin) and Floxin (ofloxacin))(Brief Article) ... find HIV Treatment: ALERTS! articles. Pay-Per-View - HIV Treatment: ALERTS! - HighBeam Research

Drug Resistance; MTB gyrase mutations identified as quinolone...  -  Apr 1, 2006
The authors continued, "MICs, enzyme inhibition, and drug-induced DNA cleavage were determined for moxifloxacin, gatifloxacin, ofloxacin, levofloxacin, ... Pay-Per-View - Obesity, Fitness & Wellness Week - Factiva, from Dow Jones

Impact of biofilms on the treatment of otitis.(Clinical report)  -  Nov 1, 2007
Topical ciprofloxacin/dexamethasone otic suspension is superior to ofloxacin otic solution in the treatment of children with acute otitis media with ... $4.95 - Ear, Nose and Throat Journal - ECNext

Press Release: Pexiganan Phase 3 Clinical Trials Results Published in...  -  Dec 17, 2008
Bacterial resistance to ofloxacin emerged in some patients who received ofloxacin, but no significant resistance to pexiganan emerged among patients who ... Pay-Per-View - PR Newswire - HighBeam Research

Niferex-150 Forte Oral : Uses, Side Effects, Interactions, Pictures, ...  -  Feb 4, 2005
Floxin (ofloxacin) US prescribing information. Ortho-McNeil Pharmaceutical, Inc. September, 2008. 6.Zagam (sparfloxacin) US prescribing information. ... WebMD

Sterile corneal ulcer with ring infiltrate and hypopyon after...  -  Sep 15, 2006
She was managed with intensive hourly topical ofloxacin 0.3% and cycloplegics three times daily. After 1 week of treatment, the appearance of the corneal ... Nature.com

Daiichi Pharmaceutical Co., Ltd. v. Apotex, Inc., No. 03-937 (DNJ...  -  Aug 1, 2006
The concentration levels of ofloxacin in the middle ear mucosa measured by the ... Hirota teaches that ofloxacin, which was disclosed as an "excellent ... $2.95 - U.S. District Court, District of New... - VersusLaw

Safety and efficacy of topical quinolones.  -  Oct 1, 2005
Ofloxacin eardrop treatment for active chronic suppurative otitis media: ... 30%) Tong et al, (6) 1996 Ofloxacin marginally superior (cure rates: 89 vs. ... $4.95 - Ear, Nose and Throat Journal - ECNext

FLUOROQUINOLONE (Oral route, Injection route, Intravenous route).( …  -  May 1, 2007
For ofloxacin: * For oral dosage form (tablets): * Adults: 200 to 400 mg every twelve hours for three to fourteen days, depending on the medical problem ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Tuberculous peritonitis: A race against time  -  Jul 5, 2006
Treatment with pyrazinamide and ofloxacin should be stopped after 3 months; rifampicin and isoniazid should be continued for a total of 12 months. ... Nature.com

[U] Summers v. Shah, 13 Misc.3d 1215(A), 824 NYS2d 759 (NYSup. 09/ …  -  Sep 22, 2006
...ruptured tendons or tendinitis, or the different types of fluoroquinolones, such as norfloxacin, ofloxacin, pefloxacin, levofloxacin and ciprofloxacin. ... $2.95 - Supreme Court of New York, X County - VersusLaw

Article: AP investigation details pharmaceuticals found in watersheds...  -  Mar 10, 2008
Columbus, Ohio: 15 (including azithromycin, erythromycin, roxithromycin, tylosin, ciprofloxacin, ofloxacin and caffeine). -- Concord, Calif. ... Pay-Per-View - Deseret News - HighBeam Research

Article: BELLEVUE WANTS TO CONVERT RENTALS.(News) - The …  -  Dec 4, 2007
Article: Experience with a decentralized IV to PO ofloxacin ... Formulary; August 1, 1999 ; 700+ words ... ... decentralized IV to PO ofloxacin conversion ... Pay-Per-View - Kentucky Post - HighBeam Research

Effectiveness Confirmed for Multi-Drug Treatment of XDR-TB  -  Aug 25, 2008
Isoniazid, amikacin, levofloxacin, moxifloxacin, and rifabutin were used only rarely, but 80% or more of XDR-TB patients received capreomycin, ofloxacin, ... MedPage Today

Levofloxacin treatment in patients with rheumatoid arthritis receiving...  -  Feb 1, 2007
Levofloxacin, the bacteriologically active isomer of ofloxacin, is used in the treatment of infections caused by periodontopathic bacteria and facultative ... Free with registration - Southern Medical Journal - AccessMyLibrary.com

Task force issues new gonorrhea guidelines  -  Jan 1, 2006
Be vigilant about use of the fluoroquinolones ciprofloxacin, ofloxacin, and levofloxacin; these drugs are not recommended for treatment of gonorrhea ... Free with registration - Contraceptive Technology Update - AccessMyLibrary.com

Drug-resistant TB Risk Management for Health Workers and Other Care …  -  Jul 11, 2008
Increased resistance to ciprofloxacin and ofloxacin in multidrug-resistant Mycobacterium tuberculosis isolates from patients seen at a tertiary hospital in ... Medscape

Antimicrobial price variation: Conundrum of medical profession!(View ...  -  Jan 1, 2007
The cheaper brands of ofloxacin namely Bestoflox (200 mg) cost as low as Rs. 21.5 and Oflomil (400 mg) was priced at Rs. 53. The deviation of price was more ... Free with registration - Journal of Postgraduate Medicine - AccessMyLibrary.com

Treat sexually transmitted infections with antibiotics, antivirals:...  -  Feb 1, 2005
Levofloxacin-- 250 mg PO once Levaquin (Ortho-McNeil) $9.14 Ofloxacin-- 400 ... 500 mg PO once x 7d Levaquin (Ortho-McNeil) $73.50 Ofloxacin-- 300 mg PO ... Free with registration - Managed Healthcare Executive - AccessMyLibrary.com

Chemotherapy And Chemoprophylaxis Of Leprosy  -  Jan 17, 2008
The combination of rifampicin-ofloxacin-minocycline (ROM) is the first fully supervisable, monthly administered regimen [4], and the efficacy of multiple ... TropIKA

Torsades de pointes following concurrent amiodarone and levofloxacin ...  -  Oct 1, 2006
Frothingham conducted a retrospective analysis of the incidence of torsades de pointes associated with the use of ciprofloxacin, ofloxacin, gatifloxacin, ... Free with registration - Baylor University Medical Center... - AccessMyLibrary.com

Ecologic impact of broad-spectrum quinolones.  -  Oct 1, 2005
Only 6 to 12% of ciprofloxacin and ofloxacin is metabolized, compared with ... Approximately 40 to 60% of ciprofloxacin, 70 to 90% of ofloxacin, ... Free with registration - Ear, Nose and Throat Journal - AccessMyLibrary.com

Levofloxacin Treatment of Active Tuberculosis and the Risk of Adverse...  -  Sep 28, 2005
The second-generation quinolone antibiotics (ofloxacin and ciprofloxacin) have moderate in vitro activity against Mycobacterium tuberculosis,9,10 but the ... RedOrbit

Spread of extensively drug-resistant tuberculosis.  -  Apr 1, 2007
The isolates were also tested on 7H10 Middlebrook agar for susceptibility to aminosalicylic acid, ethionamide, capreomycin, clarithromycin, and ofloxacin ... Free with registration - Emerging Infectious Diseases - AccessMyLibrary.com

Tympanostomy tube obstruction related to ototopical drug therapy.  -  Jul 1, 2005
Indeed, we have not yet encountered any such concretions with other ototopicals, and we even used ototopical ofloxacin to reestablish patency in 3 of our ... Free with registration - Ear, Nose and Throat Journal - AccessMyLibrary.com

Ear drops curb tube sequelae  -  Apr 4, 2007
Survey results showed patients liked the ofloxacin drops more than the combination drops and reported that they caused less pain, but compliance rates were ... AAP News - AAP News (subscription)

Wegener's Granulomatosis Mimicking a Parotid Abscess  -  Sep 30, 2005
Treatment was commenced with povidone iodine 5 per cent, ofloxacin and penicillin eye drops, but with little or no effect. Vision in the right eye was now ... RedOrbit

New combination treatment that could dramatically shorten the length...  -  Jan 10, 2006
...months of therapy and compared with standard WHO-recommended treatment and two other similar regimens which contained either ofloxacin or moxifloxacin. ... News-Medical.net

Brand Names/Synonyms:
Ofloxacin is also known by the following brand names and/or synonymsBacquinor; Baycip; Bernoflox; CIPROFLOXACIN HCL; Ciflox; Cifloxin; Ciloxan; Ciprinol; Cipro; Cipro I.V.; Cipro Xl; Cipro Xr; Ciprobay; Ciprocinol; Ciprodar; Ciprofloxacin; Ciprofloxacin Base; Ciprofloxacin Dihydrochloride; Ciprofloxacin Hydrochloride; Ciprofloxacin Monohydrochloride; Ciprofloxacina; Cipromycin; Ciproquinol; Ciproxan; Ciproxin; Flociprin; Floxin; Floxin Otic; Floxin in Dextrose 5%; Ocuflox; Ofloxacin; Proquin Xr; Septicide; Velomonit

Drug Category:
Ofloxacin is categorized under the following by the FDA: Anti-Infectives; Quinolones; ATC:J01MA02; ATC:S01AX13; ATC:S03AA07

Dosage Forms:
LIQUID; OINTMENT; SOLUTION; SUSPENSION; TABLET; TABLET (COMBINED RELEASE); TABLET (EXTENDED-RELEASE)

Absorption:
70-80%

Interactions:
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Chemical IUPAC Name:
1-cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-yl-1H-quinoline-3-carboxylicacid





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