Optison

This page contains recent news articles, when available, and an overview of Optison but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Optison (when available)

Pharmacology and use:
Regulates the colloidal osmotic pressure of blood. It is used to increase the circulating plasma volume, thereby reducing hemoconcentration and blood viscosity. Also used as a transport protein that binds naturally occurring, therapeutic and toxic materials in circulation. For treatment of severe blood loss, hypervolemia, hypoproteinemia

Mechanism Of Action:
Serum albumin acts as a high molecular weight, very soluble osmolyte

News Articles on Serum albumin

微泡造影剂�?�展现状简�?  -  ‎Oct 22, 2009‎
...第二代包括Optison�?SonoVue�?Definity�?Sonazoid�?Imagent �?PESDA�?Aerosomes�?Quanfism 等。与微泡内所�?�气体为空气的第一代造影剂�?�?�,第二代造影剂所�?�气体 ... 三九健康网

Concerns remain over heart imaging agents: FDA  -  Jun 20, 2008
The products -- which include Optison, made by General Electric Co's GE ... GE Healthcare voluntarily withdrew Optison after an FDA inspection found ... Reuters

FDA to alert doctors about imaging drugs' risks  -  Oct 8, 2007
Optison was recalled by GE Healthcare in November 2005 because of manufacturing problems. The company said last month it hoped to relaunch the product this ... Reuters UK

Bristol-Myers Strengthens Warning on Ultrasound Drug  -  Oct 11, 2007
The safety information for Optison was unchanged on the FDA Web site today. ... Definity, approved by the FDA in 2001, and Optison, allowed since 1997, ... Bloomberg

FDA asks for strong warning on imaging agents  -  Oct 13, 2007
Ten deaths have been reported with Definity and one with Optison, the US Food and Drug Administration said. Four of the 11 reported deaths were caused by ... Reuters India

FDA Updates Definity Optison Warning  -  Jul 17, 2008
Healthcare providers were notified today about labeling changes for Definity and Optison, micro-bubble contrast agents used in sonograms of the heart. ... Newsinferno.com

Definity, Optison Black Box Warning Revised  -  May 14, 2008
The Food & Drug Administration (FDA) is watering down its warning about the possible risks of Definity and Optison, micro-bubble contrast agents used during ... Newsinferno.com

GE Healthcare Announces Updates To Optison Prescribing Information  -  Jun 12, 2008
GE Healthcare announced significant updates to the Prescribing Information (PI) for its ultrasound contrast medium OPTISON TM (Perflutren Protein-Type A ... Medical News Today - Medical News Today (press release)

953. Therapeutic Ultrasound Mediated Anti- Angiogenic Gene Delivery …  -  May 1, 2006
Optison increased transfection and the distribution of the expressed protein in the tumor, ... As expected, in mice treated once with pPEX and TUS-Optison, ... Nature.com

… and output power on the ultrasonographic contrast produced by...  -  Sep 1, 2006
During fundamental imaging, Optison produced greater contrast intensity while ... However, in the harmonic mode, lower imaging frequencies caused Optison to ... Journal of Ultrasound in Medicine...

Ecocardiografia: Optison, un mezzo di contrasto a microsfere  -  Jan 17, 2008
Giovedì 17 Gennaio 2008 - Optison è una sospensione iniettabile. È costituita da microsfere di albumina umana trattata termicamente contenenti il principio ... XagenaSalute

Doctor Disputes FDA Black Box Warning on Ultrasound Contrast Agents  -  Apr 3, 2008
There are currently two micro-bubble contrast agents currently on the market – Definity, marketed by Bristol Myers Squibb, and Optison, distributed by ... Newsinferno.com

Membrane disruption by optically controlled microbubble cavitation  -  Apr 20, 2005
To retain clinical relevance, we used commercial encapsulated Optison UCAs throughout (complete system details and methodology can be found in the ... Nature.com

Annual Reports - Get Me Rewrite!  -  Dec 19, 2007
An MBI product called Optison, for example, helps cardiologists to read ... Optison allows for better imaging, helping doctors to make accurate diagnoses ... Fast Company

Panel reviews safety of drugs cleared for echocardiography  -  Sep 1, 2008
The only two FDA approved echocardiography contrast agents are Optison, ... According to the FDA, GE's Optison was not marketed from November 2005 to ... European Hospital

Ultrasound agents tied to fatal cardiac events.(NEWS FROM THE FDA)  -  Nov 15, 2007
The manufacturers of Definity (perflutren lipid microsphere) injectable suspension and Optison (perflutren protein-type A microspheres for Injection), ... Free with registration - Family Practice News - AccessMyLibrary.com

Article: Normal stress echo good for 18 months in patients with prior...  -  Feb 1, 2005
A number of clinicians reported that use of OPTISON in stress echo studies significantly improved ultrasound ... use OPTISON on a daily basis in stress echo ... Pay-Per-View - Internal Medicine News - HighBeam Research

… cardiopolmonari e casi fatali associati all'uso di Definity ed...  -  Feb 22, 2008
Definity ed Optison sono i soli prodotti a microbolle, approvati negli Stati Uniti. L'FDA ( Food and Drug Administration ) ha approvato Optison nel 1997. ... XagenaSalute

On the Usefulness of the Mechanical Index Displayed on Clinical …  -  Dec 1, 2006
Sonazoid (GE Healthcare, Oslo, Norway) and Optison (GE Healthcare, Princeton, NJ) microbubbles were injected into a tissue-mimicking flow phantom. ... Journal of Ultrasound in Medicine...

Effect of molecular weight and end capping on poly(lactic-co-glycolic...  -  Sep 1, 2008
Although Optison is currently the only FDA approved polymer shelled CA and some such as Sonovist (Schering, Berlin) with a cyanoacrylate shell, ... Pay-Per-View - Polymer Engineering and Science - HighBeam Research

Press Release: Definity Secured 24 Percent of the Echocardiography …  -  Dec 8, 2008
Optison Also Gained Market Share During the Same Study Period, ... "The gain in market share for Definity and Optison may be related to the recent formation ... Pay-Per-View - PR Newswire - HighBeam Research

Imaging; Contrast-enhanced sonography detects vascularity of …  -  Oct 24, 2005
...harmonic imaging with a low mechanical index (<.3) and second generation microbubble contrast medium (Optison, Sonovue) as echo-enhancing agent. ... Pay-Per-View - Health & Medicine Week - Factiva, from Dow Jones

FDA警告：心臟顯影劑安全堪虞  -  Nov 11, 2007
GE公�?�的Optison因製造�?題，於2005年撤銷下櫃。該公�?�希望讓此產�?於今年�?月或�??月 �?度上市。 FDA發言人朱利（Julie Zawisza）表示，�?年有百�?�人次接�?�超音波心動 ... epochtimes.com

Ecocardiografia: i mezzi di contrasto a base di microbolle possono...  -  Feb 11, 2008
Nella scheda tecnica di Definity e di Optison è stato inserito un warning ( avvertenza ) riguardo ai rischi di reazioni d'ipersensibilità e cardiopolmonari. ... XagenaSalute

BMS' Ultrasound Drug Definity Gets Black Box Warning  -  Oct 16, 2007
...cardiopulmonary reactions in patients taking Definity and GE Healthcare's ultrasound contrast drug Optison (perflutren protein Type A microspheres). ... FDA news - FDA news (subscription)

GE Sees Future Of Diagnostics In IT  -  Jan 19, 2007
One example, Hogan says, is the Optison imaging agent, used to take pictures of the arteries in the neck with ultrasound. GE got the chemical, ... Forbes

Definity Secured 24 Percent of the Echocardiography Market Share for ...  -  Dec 8, 2008
..."The gain in market share for Definity and Optison may be related to the recent formation of the International Contrast Ultrasound Society (ICUS)," stated ... RedOrbit

Suppression of tumor growth by intra-muscular transfer of naked DNA …  -  Nov 18, 2005
Different amounts of expression vectors mixed with microbubble (Optison, Mallinckrodt, St Louis, MO) were applied to the tumors. For ultrasound irradiation ... Nature.com

Serious Complications and Death Linked to Heart Imaging Drugs  -  Nov 5, 2008
According to GE Healthcare, Optison was voluntarily withdrawn from the market even before the FDA warning due to unrelated problems with a contract ... Natural News.com

Safety and Efficacy of Commercially Available Ultrasound Contrast …  -  Dec 29, 2008
Perspective: In October 2007, the FDA's mandate for a 'black box' warning on the commercial contrast agents Optison and Definity resulted in a substantial ... Cardiosource

NO.1 뉴미디어 마�?��?��?�리  -  Jun 21, 2008
21�?� 미 FDA는 GE 헬스케어사�? �?�해 제조�?�는 'Optison'�? Lantheus Medical ... GE 헬스케어�?� 'Optison'�?� 2005년 11월부터 2007년 10월까지는 시장�? 출시�?�지 ... 마�?��?��?�리

Press Release: Mindray's Laptop-size M5 and BS-200 Receive FDA …  -  Mar 31, 2008
Article: New Ultrasound Imaging Agent, Optison, Cleared by ... ... Article: OPTISON Recommended for European Approval; New Ultrasound ... ... Pay-Per-View - PR Newswire - HighBeam Research

Article: Psoriasis linked with MI, stroke, depression.(Dermatology)( …  -  Sep 15, 2008
Article: OPTISON Featured at Echocardiography Scientific Forum; OPTISON ... Business Wire; September 17, 1999 ; 700+ words ...SAN DIEGO--(BW HealthWire ... Pay-Per-View - Internal Medicine News - HighBeam Research

Q1 2006 Tyco International Earnings Conference Call - Part 1.  -  Feb 2, 2006
We recalled two products, our DTE Generators and Optison, due to sterility concerns, although there were no incidents in the marketplace and no patient ... Free with registration - America's Intelligence Wire - AccessMyLibrary.com

Onda Corporation Announces Delivery of 100th NTR AIMS Ultrasonic …  -  Dec 20, 2005
In addition to Test and Measurement products, which include the Schlieren OptiSon Beam Analyzer and the industry's most complete line of hydrophones, ... primezone.com

BRIEFS  -  Oct 9, 2007
..."labeling revisions" for its Definity, and GE Healthcare said it is talking with the FDA about changing prescribing materials for Optison, its version. ... Pay-Per-View - Newsday - ProQuest Archiver

FDA panel pans Acusphere heart-imaging drug  -  Dec 10, 2008
Imagify is similar to several drugs already on the market, including General Electric's Optison and Lantheus Medical Imaging's Definity. ... FOXNews

Article: NATIONAL BRIEFS - The Record (Bergen County, NJ) | …  -  Oct 9, 2007
GE Healthcare is also "talking with the FDA" about changing prescribing materials for Optison, its version, said Graeme Holland, a GE spokesman. ... Pay-Per-View - The Record - HighBeam Research

Drug Delivery; Targeted drug delivery achieved by focal disruption of...  -  Oct 24, 2006
Each sonication was performed after an intravenous injection of an ultrasound contrast agent (Optison). "The disruption of the BBB was evaluated with the ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

More study of heart imaging agent risks urged  -  Jun 25, 2008
Contrast agents such as GE's Optison and Lantheus's Definity make the images clearer in some cases. "It's not that a drug or a test agent is without risk. ... Reuters India

Orencia.(Drug therapy for rheumatoid arthritis )(Brief Article) |...  -  Feb 15, 2006
Two Agents Implicated Two ultrasound contrast agents, Definity (Bristol-Meyers Squibb) and Optison (GE Healthcare), are approved in the United States for ... Pay-Per-View - Internal Medicine News - HighBeam Research

Progress with a less invasive approach.(TOP 200 PACKAGERS: …  -  Jul 1, 2005
Myoview; Buckinghamshire, Omniscan; Optison U.K. 3 Medtronic Inc. Robin Turner, Paradigm; MiniMed; Minneapolis, Minn ... ... Pay-Per-View - Food & Drug Packaging - HighBeam Research

FDA panel pans Acusphere heart-imaging drug  -  Dec 11, 2008
Imagify is similar to several drugs already on the market, including General Electric's Optison and Lantheus Medical Imaging's Definity. ... Boston Globe

Medicare Drug Program has Marketing and Distribution Abuses: …  -  Oct 8, 2007
The warning, which could be issued this week, involves the Bristol-Myers Squibb drug Definity and General Electric's Optison, the Journal reported. ... DentalPlans.com

FDA orders label safety warnings for echocardiogram imaging agents.  -  Oct 15, 2007
...problems and mortalities in patients subjected to Bristol-Myers Squibb's Definity and GE Healthcare's Optison, imaging agents used in echocardiograms. ... Free with registration - Pharma Marketletter - AccessMyLibrary.com

QuantRX Biomedical Corp acquires FluoroPharma Inc - Deal Snapshot - …  -  Apr 19, 2007
Biosystems in ####, a leading biomedical company, which markets Optison, an…Developments #### ART Acquires Alerion Biomedical Canadian company ART Advanced ... Pay-Per-View - deals - Alacra Store

FDA relaxes restrictions on ultrasound imaging drugs  -  Jan 10, 2008
The decision eases warnings imposed last fall on Definity, formerly sold by Bristol-Myers Squibb, and Optison from General Electric Co. ... SmartBrief

FDA committee examines use, safety of contrast agents  -  Aug 1, 2008
The committee concentrated on two agents the FDA previously approved for use in the United States, Optison (perflutren protein-type A microspheres, ... Cardiology Today

GE Healthcare Marks Ten Years Of Vivid Innovation  -  Jun 10, 2008
In addition, the contrast agent Optison joined the GE portfolio as a result of the 2004 acquisition of the Amersham, a global leader in medical diagnostics ... Medical News Today - Medical News Today (press release)

ALSO NOTED: Abbott's Xience shows well against Boston Sci stent; …  -  May 14, 2008
...lifting a ban on administering them to acutely ill patients; Definity and Optison will still carry black-box warnings, however. Report ... FiercePharma

GE celebrates a decade of Vivid memories  -  Sep 1, 2008
GE acquired Amersham and contrast agent Optison joined the GE portfolio. 2005 – Vivid 7 gained Automated IMT (intima-media thickness) measurements and ... European Hospital

FDA orders label safety warnings for echocardiogram imaging agents.  -  Oct 15, 2007
...reports of cardiac problems and mortalities in patients subjected to Bristol-Myers Squibb's Definity and GE Healthcare's Optison, imaging agents used. $4.95 - Pharma Marketletter - ECNext

Global top 20 medical packaging companies ranked by total revenue in ...  -  Jul 1, 2007
...global pkg leader Omnipaque; Myoview; Buckinghamshire, Omniscan; Optison U.K. 3 Medtronic Inc. Robin Turner, Paradigm; MiniMed; Minneapolis, Minn. senior ... $20.00 - Food & Drug Packaging - Alacra Store

BUSQUE EN LAS NOTICIAS DE SALUD  -  Jun 25, 2008
Los agentes de contraste, como Optison de GE y Definity de Lantheus hacen que la imagen sea más clara en algunos casos. "No es que un fármaco o un agente de ... Buena Salud

美 '�?�피니티' '옵티슨' 경고 변경  -  Jul 19, 2008
...미국�?서 미세기�?� 조�?제�?� '�?�피니티'(Definity, perflutren lipid microspheres) 와 '옵티슨'(Optison, perflutren protein Type A microspheres)�? 대한 블랙박스 ... 디지틀보사

Brand Names/Synonyms:
Optison is also known by the following brand names and/or synonymsSerum albumin precursor; Optison

Drug Category:
Optison is categorized under the following by the FDA: Serum substitutes; blood derivatives (16:00.00)

Dosage Forms:
LIQUID

Absorption:
Not Available

Interactions:
Not Available

Chemical IUPAC Name:
Human serum albumin

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