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OrapredThis page contains recent news articles, when available, and an overview of Orapred but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.Overview: Orapred (when available) Prednisolone is a synthetic glucocorticoid used as antiinflammatory or immunosuppressive agent. Prednisolone is indicated in the treatment of various conditions, including congenital adrenal hyperplasia, psoriatic arthritis, systemic lupus erythematosus, bullous dermatitis herpetiformis, seasonal or perennial allergic rhinitis, allergic corneal marginal ulcers, symptomatic sarcoidosis, idiopathic thrombocytopenic purpura in adults, leukemias and lymphomas in adults, and ulcerative colitis. Glucocorticoids are adrenocortical steroids and cause profound and varied metabolic effects. In addition, they modify the body's immune responses to diverse stimuli. For the treatment of primary or secondary adrenocortical insufficiency, such as congenital adrenal hyperplasia, thyroiditis. Also used to treat psoriatic arthritis, rheumatoid arthritis, ankylosing spondylitis, bursitis, acute gouty arthritis and epicondylitis. Also indicated for treatment of systemic lupus erythematosus, pemphigus and acute rhematic carditis. Can be used in the treatment of leukemias, lymphomas, thrombocytopenia purpura and autoimmune hemolytic anemia. Can be used to treat celiac disease, insulin resistance, ulcerative colitis and liver disorders. Mechanism Of Action: Glucocorticoids such as Prednisolone can inhibit leukocyte infiltration at the site of inflammation, interfere with mediators of inflammatory response, and suppress humoral immune responses. The antiinflammatory actions of glucocorticoids are thought to involve phospholipase A2 inhibitory proteins, lipocortins, which control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes. Prednisolone reduces inflammatory reaction by limiting the capillary dilatation and permeability of the vascular structures. These compounds restrict the accumulation of polymorphonuclear leukocytes and macrophages and reduce the release of vasoactive kinins. Recent research suggests that corticosteroids may inhibit the release of arachidonic acid from phospholipids, thereby reducing the formation of prostaglandins. Prednisolone is a glucocorticoid receptor agonist. On binding, the corticoreceptor-ligand complex translocates itself into the cell nucleus, where it binds to many glucocorticoid response elements (GRE) in the promoter region of the target genes. The DNA bound receptor then interacts with basic transcription factors, causing an increase or decrease in expression of specific target genes, including suppression of IL2 (interleukin 2) expression. News Articles on Prednisolone Generic Name: Orapred, Millipred, Deltacortril, Deltastab, Prednesol - Nov 11, 2009 Prednisolone is used for the treatment of a wide range of inflammatory and auto-immune conditions such as asthma, uveitis, rheumatoid arthritis, ... Pattaya Daily News BioMarin cuts Orapred sales guidance, cuts jobs - Jul 6, 2005 ZURICH (AFX) - BioMarin Pharmaceuticals cut its 2005 sales guidance for its Orapred drug to 8-10 mln usd from 15-20 mln, as well as 52 positions from its ... Forbes … Announce North American Licensing Agreement for Orapred. - Mar 15, 2006 Orapred ODT is expected to commercially launch in the United States during the ... "Orapred no longer fits well with our core business of developing and ... Free with registration - PR Newswire - AccessMyLibrary.com Orapred ODT Arrives in US Market - Aug 28, 2006 ALPHARETTA, Ga., Aug. 28 /PRNewswire/ -- The first orally disintegrating tablet form of prednisolone available in the United States reaches pharmacies this ... RedOrbit BioMarin Announces Reduction of Orapred Sales Force. - Jul 5, 2005 NOVATO, Calif., July 5 /PRNewswire-FirstCall/ -- BioMarin Pharmaceutical Inc. (Nasdaq and SWX: BMRN) announced today that it has eliminated 58 positions, ... $4.95 - PR Newswire - ECNext Brand Names/Synonyms: Orapred is also known by the following brand names and/or synonyms.Delta.-Cortef; .Delta.-Stab; A-Methapred; Ak-Pred; Ak-Tate; Alphadrol; Articulose-50; CCRIS 980; Chloroptic-P S.O.P.; Co-Hydeltra; Codelcortone; Cordrol; Cortalone; Cotogesic; Cotolone; Decaprednil; Decortin H; Delcortol; Delta F; Delta-Cortef; Delta-Stab; Deltacortenol; Deltacortril; Deltacortril Enteric; Deltahydrocortisone; Deltasolone; Deltisilone; Depo-Medrol; Derpo Pd; Dexa-Cortidelt Hostacortin H; Di-Adreson F; Dicortol; Donisolone; Dydeltrone; Eazolin D; Econopred; Econopred Plus; Erbacort; Erbasona; Estilsona; Fernisolone; Fernisolone P; Fernisolone-P; Flamasone; HSDB 3385; Hostacortin H; Hydeltra; Hydeltra-Tba; Hydeltrasol; Hydeltrone; Hydrodeltalone; Hydrodeltisone; Hydroretrocortin; Hydroretrocortine; I-Pred; Inflamase Forte; Inflamase Mild; K 1557; Key-Pred; Klismacort; Lentosone; Lite Pred; M-Predrol; Medrol; Medrol Acetate; Metacortandralone; Methylprednisolone; Methylprednisolone Acetate; Methylprednisolone Sodium Succinate; Meti-Derm; Meticortelone; Meticortelone;Sterolone; Metreton; NSC 9120; NSC9900; Nisolone; Nor-Pred T.B.A.; Ocu-Pred; Ocu-Pred Forte; Ophtho-Tate; Orapred; PRDL; Panafcortelone; Paracortol; Paracotol; Pediapred; Precortalon; Precortancyl; Precortilon; Precortisyl; Pred Forte; Pred Mild; Predair; Predair A; Predair Forte; Predalone 50; Predalone T.B.A.; Predate Tba; Predate-50; Predcor-25; Predcor-50; Predcor-Tba; Predisolone Sodium Phosphate; Predne-Dome; Prednelan; Predni-Dome; Prednicen; Predniliderm; Predniretard; Prednis; Prednisolona [Inn-Spanish]; Prednisolone; Prednisolone Acetate; Prednisolone Sodium Phosphate; Prednisolone Tebutate; Prednisolone [Ban:Inn:Jan]; Prednisolonum [Inn-Latin]; Predonin; Predonine; Prelone; Prenolone; Rolisone; Scherisolon; Solone; Solu-Medrol; Steran; Sterane; Sterolone; Supercortisol; Ulacort; Ultra Pred; Ultracorten H; Ultracortene H; Ultracortene-H; Ultracortene-Hydrogen Drug Category: Orapred is categorized under the following by the FDA: Antineoplastic Agents; Glucocorticoids; Anti-inflammatory Agents; Adrenergic Agents; ATC:A07EA01; ATC:C05AA04; ATC:D07AA01; ATC:D07AA03; ATC:D07AC14; Dosage Forms: SOLUTION Absorption: Readily absorbed by gastrointestinal tract, peak plasma concentration is reached 1-2 hours after administration Interactions: Not Available Chemical IUPAC Name: 11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one |
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