Orinase

This page contains recent news articles, when available, and an overview of Orinase but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Orinase
(when available)

Pharmacology and use:
Tolbutamide, a second-generation sulfonylurea antidiabetic agent, is used with diet to lower blood glucose levels in patients with diabetes mellitus type II. Tolbutamide is twice as potent as the related second-generation agent glipizide. For the management of hyperglycemia in non-insulin-dependent diabetes mellitus (NIDDM)

Mechanism Of Action:
Sulfonylureas likely bind to ATP-sensitive potassium-channel receptors on the pancreatic cell surface, reducing potassium conductance and causing depolarization of the membrane. Depolarization stimulates calcium ion influx through voltage-sensitive calcium channels, raising intracellular concentrations of calcium ions, which induces the secretion, or exocytosis, of insulin.

News Articles on Tolbutamide

Denuncian una paliza de empleados de la discoteca Podium a varios jóvenes  -  ‎Oct 27, 2009‎
...avenida de Chinales, después de que uno de los quince integrantes del grupo de amigos orinase tras una valla que linda con la fachada lateral de Podium. ... ABC.es

El extraño caso de Torrecedeira  -  ‎Oct 30, 2009‎
Por eso, su familia no descarta que el joven orinase frente a un muro de espaldas y alguien, posiblemente un ladrón, le golpease con un objeto contudente en ... La Voz de Galicia

Orinase.(Drug overview)  -  Jan 22, 2007
Orinase is an oral antidiabetic medication used to treat type 2 (non-insulin-dependent) diabetes. Diabetes occurs when the body does not make enough insulin ... Free with registration - PDR Family Guide to Prescription Drugs - AccessMyLibrary.com

Orinase.(Drug overview)  -  Dec 1, 2005
Orinase is an oral antidiabetic medication used to treat type 2 (non-insulin-dependent) diabetes. Diabetes occurs when the body does not make enough insulin ... Free with registration - PDR Family Guide to Prescription Drugs - AccessMyLibrary.com

Sulfonylureas for Type 2 Diabetes Drugs Linked to Heart Deaths  -  Jan 17, 2006
This study found a higher rate of cardiovascular death in patients taking Orinase (tolbutamide) compared with placebo. However, subsequent evidence has been ... MedPage Today

Antidiabetic Agents, Sulfonylurea (Systemic).  -  Aug 1, 2006
In the U.S. -- Amaryl(4) DiaBeta(6) Diabinese(2) Dymelor(1) Glucotrol(5) Glucotrol XL(5) Glynase PresTab(6) Micronase(6) Orinase(8) Tolinase(7) In Canada ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Sulfonylureas Linked to Heart Deaths  -  Jan 31, 2006
This study found a higher rate of cardiovascular death in patients taking Orinase (tolbutamide) compared with placebo. However, subsequent evidence has been ... Diabetes In Control

Medical News: Alternative Medicine  -  Apr 5, 2006
The volunteers were given caffeine, Orinase, dextromethorphan and oral and intravenous Versed both before and after a short course of echinacea (400 mg QID ... MedPage Today

Antidiabetic Agents, Sulfonylurea (Systemic).(Disease/Disorder...  -  May 1, 2006
In the U.S. -- Amaryl(4) DiaBeta(6) Diabinese(2) Dymelor(1) Glucotrol(5) Glucotrol XL(5) Glynase PresTab(6) Micronase(6) Orinase(8) Tolinase(7) In Canada ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

In the News; Heart failure risk prompts warning labels on diabetes...  -  Aug 1, 2007
Drugs in this class include glimepiride (Amaryl), glipizide (Glucotrol), glyburide (Diabeta, Glynase, Micronase), and tolbutamide (Orinase). ... Free with registration - Harvard Women's Health Watch - AccessMyLibrary.com

St. Paul Pioneer Press : MANY MEDS DON'T MIX WITH THE SUN  -  Sep 21, 2005
...chlorpro-pamide (Diabinese), glimepiride (Amaryl), glipizide (Glucotrol), glyburide (DiaBeta, Micronase), tolazamide (Tolinase), tolbuta-mide (Orinase). ... $2.95 - St. Paul Pioneer Press - NewsBank

Diabetes drugs have a dark history  -  Jun 18, 2007
Patients taking the oral diabetes medication tolbutamide (Orinase) had a higher rate of cardiovascular death than patients on placebo or insulin. ... $3.50 - Press Telegram - NewsBank

New research poses dilemma for treating diabetes  -  Jun 30, 2008
This study was the most ambitious diabetes trial at the time, but patients who received the oral diabetes medication tolbutamide (Orinase) had a higher rate ... $3.50 - Press Telegram - NewsBank

El empresario Rafael Avila recibió maltrato psicológico continuo...  -  Jun 19, 2008
Al parecer le mantenían en un colchón sucio y le dejaban incluso que se orinase encima, durante un período en el que el primo de Mariano Rajoy implicado, ... Diario de Navarra

Psychiatric Times. Sweet Sorrow: The Relationship Between Depression ...  -  Apr 1, 2005
...particularly if it includes insulin or sulfonylurea oral hypoglycemic medications (tolbutamide [Orinase], glipizide [Glucotrol], glyburide [Diabeta], ... Psychiatric Times

H is for Hypo  -  May 31, 2007
The first-generation sulfonylureas include Dymelor (acetohexamide), Diabinese (chlorpropamide), Orinase (tolbutamide), Tolinase (tolazamide). ... HealthCentral.com

Médico del Tau asegura que evolución de Prigioni es 'muy buena'  -  May 20, 2006
...'Todo ello hizo que el pasado jueves, día del primer choque contra el Akasvayu Girona en pista vitoriana, el jugador orinase unas gotas de sangre, ... Terra España

PEOPLE'S PHARMACY: Diabetes drugs have a dark history  -  Jun 21, 2007
Patients taking the oral diabetes medication tolbutamide (Orinase) had a higher rate of cardiovascular death than patients on placebo or insulin. ... Tuscaloosa News - Tuscaloosa News (subscription)

Abascal: "Orinándose en los pantalones han demostrado lo cobardes …  -  Dec 9, 2008
En declaraciones a LD, Santiago Abascal señaló que el hecho de que Aitzol Iriondo se orinase en los pantalones en el momento de su detención "debe llevar a ... libertaddigital.com

How to take Irbesartan from Consumer Reports Health.  -  Jan 5, 2007
Be sure to mention any of the following: diuretics ('water pills'), nifedipine (Adalat, Procardia), and tolbutamide (Orinase). ... consumerreports.org

Levaquin.(Drug overview)  -  Jan 22, 2007
Also, check with your doctor before combining Levaquin with an oral diabetes drug such as Glucotrol, Micronase, or Orinase; changes in blood sugar levels ... Free with registration - PDR Family Guide to Prescription Drugs - AccessMyLibrary.com

Antifungals, Azole (Systemic).(Drug overview)  -  May 1, 2006
Diabinese], glipizide [eg, Glucotrol], glyburide [eg, DiaBeta, Micronase], tolbutamide [eg, Orinase]) -- May cause hypoglycemia (low blood sugar). ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Vivir joven, morir rápido  -  Jun 16, 2005
Según Ricky, ella le pidió que la orinase y él no dudó en hacerlo. Después de eso, nunca más volví a sacar el auto del garaje. Una vez vino el puntero y el ... rock.com.ar

Comentarios a la noticia - Libertad Digital  -  Dec 10, 2008
No creo que Ortega Lara ni ninguno de los que ha asesinado esta gentuza se orinase, de lejos tienen mucha más categoría, y lo demuestran cada día, ... libertaddigital.com

Avoid the Potential Interactions of Exercise and Diabetic Medications  -  Aug 28, 2007
Older-generation sulfonylureas (such as Diabinese and Orinase) cause insulin release from your pancreas and somewhat decrease your insulin resistance. ... Diabetes In Control

Side Effects. Side effects include:  -  Jul 15, 2006
...chlorpropamide (Diabinese), tolazamide (Tolinase), acetohexamide (Dymelor), glipizide (Glucotrol), tolbutamide (Orinase), and glimepiride (Amaryl). ... HealthCentral.com

El descontrol de los controles antidopaje  -  Mar 19, 2008
..."A otro ciclista que estaba en pleno entrenamiento le obligaron a detenerse para que orinase, porque no le encontraron en su casa. ... 20minutos.es

Avandia.(Drug overview)  -  Jan 22, 2007
...metformin (Glucophage), or a member of the sulfonylurea class of diabetes drugs (Diabinese, Micronase, Orinase). It takes effect slowly. ... Free with registration - PDR Family Guide to Prescription Drugs - AccessMyLibrary.com

Diabetes Can Be Managed, Healthy Lifestyle Best Prescription  -  Dec 29, 2006
The first drug in this class was a drug manufactured by the Upjohn Company called Orinase (tolbutamide). Subsequently, newer drugs with a variety of ... Alameda Sun

La libertad de los modernos.(Reseña de libro)  -  Jun 1, 2005
No fue Chateaubriand ningún beato defensor del Trono y del Altar, y antes que Sartre se orinase en su tumba en nombre de la izquierda, el ultra Charles ... $4.95 - Letras Libres - ECNext

Oral Medicines for Type 2 Diabetes  -  Jul 18, 2006
...tolazamide (Tolinase), and tolbutamide (Orinase)—works most successfully in those who have recently been diagnosed with Type 2 diabetes. ... Diabetes Self Management

Sun Herald : Photosensitive medicines listed  -  Aug 23, 2007
...chlorpropamide (Diabinese); glimepiride (Amaryl); glipizide (Glucotrol); glyburide (DiaBeta, Micronase); tolazamide (Tolinase); tolbutamide (Orinase). ... $2.95 - Sun Herald - NewsBank

Antiadrenal Ketoconazole Antifungal, systemic Fluconazole Itraconazole...  -  Aug 1, 2006
Diabinese], glipizide [eg, Glucotrol], glyburide [eg, DiaBeta, Micronase], tolbutamide [eg, Orinase]) -- May cause hypoglycemia (low blood sugar). ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Diabetes mellitus: type 2.(Disease/Disorder overview)  -  May 24, 2006
Examples of this type of medicine are tolbutamide (Orinase), tolazamide (Tolinase), glyburide (DiaBeta, Glynase, Micronase), glipizide (Glucotrol), ... $4.95 - Clinical Reference Systems - ECNext

Pharma and medical breakthroughs.(THE PSYCHIATRIST'S TOOLBOX)( …  -  Sep 1, 2007
In the 1950s, we saw the emergence of Orinase (tolbutamide), Terramycin (oxytetracycline), Chlor-Trimeton (chlorpheniramine), Cortone (cortisone acetate), ... $4.95 - Clinical Psychiatry News - ECNext

Drugstore pioneer OKaye with new life  -  Dec 19, 2007
He filled eight prescriptions the first day and still remembers the very first, a tablet for diabetes called Orinase (no longer used) for a woman who lived ... $2.95 - Record-Journal - NewsBank

Diabetes mellitus: type 2.(Pediatric Advisor 2006)(Disease/Disorder …  -  Nov 1, 2006
Examples of this type of medicine are tolbutamide (Orinase), tolazamide (Tolinase), glyburide (DiaBeta, Glynase, Micronase), glipizide (Glucotrol), ... $4.95 - Clinical Reference Systems - ECNext

Diabetes mellitus: type 2.(Pediatric Advisor 2007)(Disease/Disorder …  -  May 31, 2007
Examples of this type of medicine are tolbutamide (Orinase), tolazamide (Tolinase), glyburide (DiaBeta, Glynase, Micronase), glipizide (Glucotrol), ... $4.95 - Clinical Reference Systems - ECNext

Press of Atlantic City, The : Question & Answer from the pharmacy:...  -  Aug 27, 2007
...chlorpropamide (Diabinese); glimepiride (Amaryl); glipizide (Glu-cotrol); glyburide (DiaBeta, Micronase); tolazamide (Tolinase); tolbutamide (Orinase). ... $2.95 - Press of Atlantic City, The - NewsBank

El Manneken Pis  -  Nov 22, 2006
Coincidiendo con el centenario del Sporting de Gijón, sus directivos consiguieron que durante unas horas, el muñeco orinase sidra. Recuerdo que cuando Juan ... laverdad.es

Brand Names/Synonyms:
Orinase is also known by the following brand names and/or synonymsAglicid; Apo-Tolbutamide; Arkozal; Artosin; Artozin; BZ 55; Butamid; Butamide; D 860; Diaben; Diabetamid; Diabetol; Diabuton; Diasulfon; Dirastan; Dolipol; Drabet; Glyconon; HLS 831; Ipoglicone; Mobenol; Novo-Butamide; Orabet; Oralin; Orezan; Orinase; Orinase Diagnostic; Orinaz; Oterben; Pramidex; Rastinon; Restinon; Sk-Tolbutamide; Tolbusal; Tolbutamid; Tolbutamide; Tolbutamide.; Toluina; Tolumid; Toluvan; Tolylsulfonylbutylurea; U-2043; Willbutamide

Drug Category:
Orinase is categorized under the following by the FDA: Hypoglycemic Agents; Sulfonylureas; ATC:A10BB03; ATC:V04CA01

Dosage Forms:
TABLET

Absorption:
Well absorbed, not affected by food consumption

Interactions:
Not Available



Chemical IUPAC Name:
3-butyl-1-(4-methylphenyl)sulfonyl-urea





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