Orphenadrine

This page contains recent news articles, when available, and an overview of Orphenadrine but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Orphenadrine
(when available)

Pharmacology and use:
Orphenadrine is indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomfort associated with acute painful musculoskeletal conditions. Orphenadrine is an anticholinergic with a predominantly central effect and only a weak peripheral effect. In addition, it has mild antihistaminic and local anaesthetic properties. Parkinson's syndrome is the consequence of a disturbed balance between cholinergic and dopaminergic neurotransmission in the basal ganglia caused by a decrease in dopamine. Orphenadrine restores the physiological equilibrium and has a favourable effect on the rigidity and tremor of Parkinson's disease and Parkinsonian syndromes. The effect is somewhat less on bradykinesia. Indicated for the treatment of Parkinson's disease.

Mechanism Of Action:
Orphenadrine binds to both histamine H1 receptors and NMDA receptors. It restores the motor disturbances induced by neuroleptics, in particular the hyperkinesia. The dopamine deficiency in the striatum increases the stimulating effects of the cholinergic system. This stimulation is counteracted by the anticholinergic effect of orphenadrine. It may have a relaxing effect on skeletal muscle spasms and it has a mood elevating effect.

News Articles on Orphenadrine

Generic Name: Orphenadrine, Orphenace, Rhoxal-orphendrine, Biorphen, Disipal ...  -  ‎Nov 11, 2009‎
Norflex (generic name: Orphenadrine; brand names include: Disipal / Biorphen / Disipal / Mioflex / Orphipal / Relaflex) belongs to a group of medicines ... Pattaya Daily News

Four Pharmaceutical Companies Pay $124 Million for Submission of False Claims ...  -  ‎Oct 19, 2009‎
...flecainide acetate, selegiline HCL, Orphenadrine Citrate Aspirin and Caffeine tablets, Triamterene/Hydrochlorothiazide, Propoxyphene HCL, ... Reuters

Orphenadrine (Systemic).  -  Jul 28, 2005
Orphenadrine ( or-FEN-a-dreen) is used to help relax certain muscles in your body and relieve the stiffness, pain, and discomfort caused by strains, ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Orphenadrine (Systemic).(Drug overview)  -  Aug 1, 2006
Orphenadrine ( or-FEN-a-dreen) is used to help relax certain muscles in your body and relieve the stiffness, pain, and discomfort caused by strains, ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Orphenadrine and Aspirin (Systemic).  -  Oct 27, 2005
...(***)In Canada, ( Aspirin) is a brand name. Acetylsalicylic acid is the generic name in Canada. ASA, a synonym for acetylsalicylic acid, is the term that ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Protecting Competition, the Federal Trade Commission Approves …  -  Jul 20, 2005
Orphenadrine citrate ER, a muscle relaxant, has annual US generic sales of approximately ... Likewise, in the orphenadrine citrate ER and rifampin markets, ... i-newswire.com

Akorn, Inc. Announces Product Approval for Orphenadrine Citrate …  -  May 24, 2006
BUFFALO GROVE, Ill. -- Akorn, Inc. (AMEX:AKN) today announced that it has received an ANDA approval for Orphenadrine Citrate Injection USP. ... Free with registration - Business Wire - AccessMyLibrary.com

… - 77 Ill. Adm. Code 790.1200 ASPIRIN; CAFFEINE; ORPHENADRINE ( …  -  Aug 10, 2005
77 Ill. Adm. Code 790.1200 ASPIRIN; CAFFEINE; ORPHENADRINE (Repealed) Repealed. (Source: Repealed at 14 Ill. Reg. 8154, effective May 11, 1990) ... Pay-Per-View - Illinois Administrative Code - Loislaw

… Administrative Code - 77 Ill. Adm. Code 790.6820 ORPHENADRINE …  -  Aug 10, 2005
77 Ill. Adm. Code 790.6820 ORPHENADRINE CITRATE (Repealed) Repealed. (Source: Repealed at 17 Ill. Reg. 15916, effective September 20, 1993) ... Pay-Per-View - Illinois Administrative Code - Loislaw

港府:泰國製「散根丸ã€?å?«è¥¿è—¥æœ‰å‰¯ä½œç”¨  -  Aug 3, 2005
...全部藥丸都�西藥�分,其中粉紅藥丸�Orphenadrine�黃色膠囊�Indomethacin�橙色 ... 衛生署指出,Orphenadrine是肌肉鬆弛劑,�引起�乾�視力模糊�心跳��律。 ... epochtimes.com

Coroner warns of dangers of internet drugs after policewoman overdoses  -  Nov 28, 2008
The coroner said Orphenadrine, like many drugs, could be purchased very cheaply on the internet. He added: "I think this is probably a more dangerous drug ... Telegraph.co.uk

Novartis' purchase of Eon approved with conditions.  -  Aug 29, 2005
In the orphenadrine citrate ER and rifampin markets Impax Laboratories Inc. and VersaPharm, respectively, are the only other generic competitors. ... $9.94 - Chain Drug Review - Alacra Store

BRIEFS  -  Jul 20, 2005
...hydrochloride tablets, orphenadrine citrate extended release tablets and rifampin oral capsules in the United States to Amide Pharmaceutical Inc. ... Pay-Per-View - Newsday - ProQuest Archiver

Drug/Medical Device  -  Mar 14, 2006
Norflex BID/Norflex Injectable (Orphenadrine Citrate), Musculoskeletal Pain, Dryness Of Mouth, ... Norgesic/Norgesic Forte (Orphenadrine/Aspirin/Caffeine) ... $70.00 - Revere Reports - Revere

Community airs concerns , Laurelton residents squre off with a local...  -  Mar 3, 2005
Eon makes orphenadrine citrate, an active ingredient found in a generic version ... Increased production of orphenadrine citrate could raise the amount of ... Pay-Per-View - Newsday - ProQuest Archiver

FDA finds Sandoz paperwork troubling  -  Aug 27, 2008
The plant, which employs about 450, makes generic medicines, including the heart drug metoprolol succinate, muscle relaxer orphenadrine citrate and ... News & Observer

Official warns against Internet medication  -  Nov 29, 2008
Lynne Manklow, a 44-year-old woman with multiple sclerosis, was found dead at her home in Cheltenham after taking the muscle relaxer Orphenadrine, ... United Press International

Article: Novartis' purchase of Eon approved with conditions.(Novartis...  -  Aug 29, 2005
Furthermore, Novartis, through its Sandoz generic pharmaceutical unit, will supply Amide with orphenadrine citrate ER and desipramine HCI tablets until ... Pay-Per-View - Chain Drug Review - HighBeam Research

How can my wife ease her leg cramps?  -  Apr 18, 2008
Drugs that have been tried in the past include mephenesin, carisoprodol, carbamate, orphenadrine and tranquillisers such as diazepam. ... Daily Mail

Epirubicin/paclitaxel/etoposide in extensive-stage small-cell lung...  -  Apr 4, 2006
Premedication for paclitaxel consisted of 20 mg desamethasone by iv infusion 30 min before treatment; orphenadrine 40 mg im plus iv cimetidine 300 mg 1 h ... Nature.com

Kansas Regulations - 129-5-1. Prior authorization.  -  Nov 3, 2005
...(B) orphenadrine; (C) carisoprodol; (D) carisoprodol-aspirin; ... (G) metaxolone; (H) dantrolene; and (I) orphenadrine-aspirin-caffeine; (26) narcotics: ... Pay-Per-View - Kansas Regulations - Loislaw

Leg Cramps: Part II  -  Oct 20, 2008
These include: naftidrofuryl, vitamin E, verapamil, diltiazem, painkillers, aspirin, orphenadrine, magnesium, calcium, and sodium chloride. ... Mmegi Online

Federal Register 2005 - 70 FR 42548 Novartis AG; Analysis of Agreement...  -  Jul 25, 2005
...and the Sandoz assets necessary to manufacture and market orphenadrine ... orphenadrine citrate ER tablets, and (3) generic rifampin oral capsules. ... Pay-Per-View - Federal Register 2005 - Loislaw

Why has my child got a cold all year round?  -  Apr 15, 2008
Drugs that have been tried in the past include mephenesin, carisoprodol, carbamate, orphenadrine and tranquillisers such as diazepam. ... Daily Mail

Ghana Football Association ::: Print News  -  Feb 24, 2007
Norflex orphenadrine risk of dependence. Headache-preventing medicines may take acetaminophen butalbital caffeine there is intended to take this drug ... Ghana Football Association

How to take Bupropion from Consumer Reports Health.  -  Jan 8, 2007
...nicotine patch; oral steroids such as dexamethasone (Decadron, Dexone), methylprednisolone (Medrol), and prednisone (Deltasone); orphenadrine (Norflex); ... consumerreports.org

Arkansas Workers' Compensation Decisions - SERATT v. PHARMERICA, …  -  Nov 30, 2007
She also indicated she was taking Hydrocodone, Orphenadrine and Sulindac for some myalgias and arthralgias which had developed a year before. ... Pay-Per-View - Arkansas Workers' Compensation Decisions - Loislaw

Potassium Supplements (Systemic).  -  Feb 1, 2006
Ritalin) or Orphenadrine (e.g., Norflex) or Oxybutynin (e.g., Ditropan) or Procainamide (e.g., Pronestyl) or Promethazine (e.g., Phenergan) or Quinidine ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Antifungals, Azole (Systemic).(Drug overview)  -  May 1, 2006
Atrovent) or Meclizine (eg, Antivert) or Methylphenidate (eg, Ritalin) or Orphenadrine (eg, Norflex) or Oxybutynin (eg, Ditropan) or Procainamide (eg, ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Potassium Supplements (Systemic).  -  May 1, 2006
Ritalin) or Orphenadrine (e.g., Norflex) or Oxybutynin (e.g., Ditropan) or Procainamide (e.g., Pronestyl) or Promethazine (e.g., Phenergan) or Quinidine ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Sign up for our General newsletter to get all the latest health news  -  Mar 17, 2008
...anti-epileptic drug; antihistamine - cyclizine used to treat hay fever and orphenadrine, which is used in combination with aspirin as a muscle relaxant. ... Health24.com

Skeletal Muscle Relaxants (Systemic).  -  Feb 1, 2006
This information does (not) apply to Baclofen, Cyclobenzaprine, Dantrolene, Diazepam, or Orphenadrine. (s.)Generic name product may be available in Canada ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Bupropion, bupropion sustained release, bupropion extended release ( …  -  Jun 1, 2006
...isocarboxazid (Marplan), orphenadrine (Norflex) or cyclophosphamide (Cytoxan), as these drugs could increase bupropion's effects. ... Free with registration - Brown University Psychopharmacology... - AccessMyLibrary.com

Article: Amide gets 3 products in Novartis divestiture - The Record (...  -  Jul 20, 2005
...desipramine hydrochloride, a tricyclic antidepressant; orphenadrine citrate ER, a muscle relaxant; and rifampin; a drug used in treating tuberculosis. ... Pay-Per-View - The Record - HighBeam Research

Bupropion [sustained release, extended release] (generic); Wellbutrin,...  -  Jan 1, 2006
...such as phenelzine (Nardil), tranylcypromine (Parnate), isocarboxazid (Marplan), orphenadrine (Norflex) or cyclophosphamide (Cytoxan). ... Free with registration - Brown University Child and Adolescent... - AccessMyLibrary.com

ALSO NOTED: Aphton files for bankruptcy; Akorn wins FDA OK; and much …  -  May 23, 2006
Akorn shares were on the rise after reporting FDA approval of an ANDA for Orphenadrine Citrate Injection. Report. > Wyeth has developed a new contraceptive ... FierceBiotech

Docetaxel (Systemic).  -  Aug 1, 2006
Erythromycins (medicine for infection) or Ketoconazole (eg, Nizoral) or Midazolam (eg, Versed) or Orphenadrine (eg, Norflex) or Testosterone (male hormone) ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Thyroid function test: a clinical lab perspective.(Cover story)  -  Feb 1, 2007
...(12) In psychiatric patients treated with orphenadrine, increased levels of [T.sub.3] have been observed while treatment with lithium appears to affect ... Free with registration - Medical Laboratory Observer - AccessMyLibrary.com

Antiadrenal Ketoconazole Antifungal, systemic Fluconazole Itraconazole...  -  Aug 1, 2006
Atrovent) or Meclizine (eg, Antivert) or Methylphenidate (eg, Ritalin) or Orphenadrine (eg, Norflex) or Oxybutynin (eg, Ditropan) or Procainamide (eg, ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Novartis Receives US Regulatory Approval for Completion of Eon Labs …  -  Jul 19, 2005
Pursuant to the Consent Decree, Novartis will divest three generic pharmaceutical products, Desipramine HCl, Orphenadrine Citrate ER and Rifampin, ... primezone.com

Novartis wraps up Eon.(Noted)  -  Aug 1, 2005
Under a proposed consent order with FTC, Novartis agreed to divest three generic drugs--Sandoz' muscle relaxant orphenadrine and tuberculosis treatment ... Free with registration - Pharmaceutical Processing - AccessMyLibrary.com

Thyroid function test: a clinical lab perspective.(Cover story)  -  Feb 1, 2007
...(12) In psychiatric patients treated with orphenadrine, increased levels of [T.sub.3] have been observed while treatment with lithium appears to affect ... $4.95 - Medical Laboratory Observer - ECNext

Norgesic.(Drug overview)  -  Dec 1, 2005
If you are sensitive to or have ever had an allergic reaction to the ingredients of Norgesic--orphenadrine, aspirin, and caffeine--you should not take this ... Free with registration - PDR Family Guide to Prescription Drugs - AccessMyLibrary.com

Akorn gets approval for injection drug  -  May 25, 2006
The company will make the Orphenadrine Citrate injection in its Decatur facility. The launch is expected in the third quarter. ... $2.95 - Daily Herald - NewsBank

Akorn, Inc. Reports Second Quarter 2006 Revenues Of $12.5 Million And...  -  Jul 26, 2006
...--Seven product approvals were received from the FDA: Brimonidine, Inapsine(R), Orphenadrine, Sufenta(R), Alfenta(R), Amiodarone, and Dilitiazem. ... $4.95 - Business Wire - ECNext

Local Focus.(Business) | Article from Daily Herald (Arlington...  -  May 25, 2006
The company will make the Orphenadrine Citrate injection in its Decatur facility. The launch is expected in the third quarter. ... Pay-Per-View - Daily Herald - HighBeam Research

Novartis completes Eon Labs acquisition.(Brief Article)  -  Aug 1, 2005
These are desipramine, orphenadrine citrate and rifampin, which had aggregate sales of around $5.0 million in 2004. They have been sold to Amide ... $4.95 - Pharma Marketletter - ECNext

United States top 200 generic drugs by retail sales in dollars for...  -  Feb 28, 2005
Promethazine supplement 43009 150 Captopril 41972 151 Nefazodone HCl 40670 152 Butorphanol NS 40319 153 Nadolol 40174 154 Orphenadrine citrate 39883 155 ... $20.00 - Chain Drug Review - Alacra Store

Novartis wraps up Eon.(Noted) | Article from Pharmaceutical Processing...  -  Aug 1, 2005
Under a proposed consent order with FTC, Novartis agreed to divest three generic drugs--Sandoz' muscle relaxant orphenadrine and tuberculosis treatment ... Pay-Per-View - Pharmaceutical Processing - HighBeam Research

United States top 200 generic drugs by retail sales in dollars and...  -  Mar 6, 2006
37255 -16.1 177 Nadolol 36906 -8.1 178 Atenolol Chlorthal 36749 0.1 179 Methimazole 36587 -2.3 180 Ciclopirox 36259 576.6 181 Orphenadrine Citrate 36149 ... $20.00 - Drug Topics - Alacra Store

IN BRIEF: Rx endorsements.(Department of Health and the National …  -  Aug 13, 2005
...orphenadrine 50mg tablets * sodium cromoglicate 5mg inhaler 112 dose, and * diamorphine 5mg, 10mg, 30mg, 100mg and 500mg injection ampoules. ... $4.95 - Chemist & Druggist - ECNext

Hearing held for Kellyville man charged in drug case  -  Apr 1, 2005
Officers also reported finding marijuana, a smoking pipe, rolling papers, hemostats and several white pills later identified as Loratab, and Orphenadrine. ... Bartlesville Examiner Enterprise

New Jersey Administrative Code - 10:58A-4.3 HCPCS procedure codes …  -  Aug 16, 2005
0.5 mg 152.00 J2352 Injection, octreotide acetate, 1 mg 152.87 J2355 Injection, oprelvekin, 5 mg 258.75 J2360 Injection, orphenadrine citrate, (Norflex, ... Pay-Per-View - New Jersey Administrative Code - Loislaw

Brand Names/Synonyms:
Orphenadrine is also known by the following brand names and/or synonymsAntiflex; BS-5930; Banflex; Biorphen; Brocadisipal; Brocasipal; Disipal; Flexoject; Mephenamine; Mio-Rel; Myolin; Myotrol; Norflex; O-Methyldiphenhydramine; Orfro; Orphenadine; Orphenadrin; Orphenadrine; Orphenadrine Citrate; Orphenate; Orphenedrine; WS 2434

Drug Category:
Orphenadrine is categorized under the following by the FDA: Muscle Relaxants; Antiparkinson Agents; Antidyskinetics; Skeletal Muscle Relaxants; ATC:M03BC01; ATC:N04AB02

Dosage Forms:
TABLET (EXTENDED-RELEASE)

Absorption:
Orphenadrine is almost completely absorbed in the gastrointestinal tract.

Interactions:
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Chemical IUPAC Name:
N,N-dimethyl-2-[(2-methylphenyl)-phenyl-methoxy]-ethanamine





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