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PenciclovirThis page contains recent news articles, when available, and an overview of Penciclovir but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.Overview: Penciclovir (when available) Penciclovir is the active metabolite of the oral product famciclovir. The more favorable results observed with topical penciclovir versus topical acyclovir for the treatment of herpes labialis may be due to the longer intracellular half-life of penciclovir in HSV-infected cells. Used to treat recurrent cold sores on the lips and face. Mechanism Of Action: Penciclovir has in vitro activity against herpes simplex virus types 1 (HSV-1) and 2 (HSV-2). In cells infected with HSV-1 or HSV-2, viral thymidine kinase phosphorylates penciclovir to a monophosphate form. The monophosphate form of the drug is then converted to penciclovir triphosphate by cellular kinases. The intracellular triphosphate of penciclovir is retained in vitro inside HSV-infected cells for 10-20 hours, compared with 0.7-1 hour for acyclovir. in vitro studies show that penciclovir triphosphate selectively inhibits viral DNA polymerase by competing with deoxyguanosine triphosphate. Inhibition of DNA synthesis of virus-infected cells inhibits viral replication. In cells not infected with HSV, DNA synthesis is unaltered. Resistant mutants of HSV can occur from qualitative changes in viral thymidine kinase or DNA polymerase. The most commonly encountered acyclovir-resistant mutants that are deficient in viral thymidine kinase are also resistant to penciclovir. News Articles on Penciclovir A population pharmacokinetic model for penciclovir in human eye and … - Jul 11, 2007 Penciclovir, the metabolite of famciclovir, is a nucleoside analogue active against varicella zoster and herpes simplex type I, II and Ebstein-Barr virus. ... Nature.com … Therapeutics Launches Denavir(R) (Penciclovir Cream) in Canada - Aug 23, 2006 PRINCETON, NJ -- August 23, 2006 -- Barrier Therapeutics, Inc., a pharmaceutical company developing and commercializing products in the field of dermatology ... DG News Penciclovir (Topical).(Drug overview) - May 1, 2006 Penciclovir ( pen-SYE-kloe-veer) belongs to the family of medicines called antivirals. Antivirals are used to treat infections caused by viruses. ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com Loislaw Federal District Court Opinions - NOVARTIS … - Sep 6, 2007 Page 3 Penciclovir is the active compound in famciclovir. Penciclovir is a member of the acyclic nucleosides group of compounds. Since the late 1970s, ... Pay-Per-View - Loislaw Federal District Court Opinions - Loislaw In brief: Penciclovir switch? - Jan 28, 2006 Novartis Consumer Health has applied for a POM to P switch for penciclovir 1 per cent cream. According to the proposal, Fenestil Cold Sore Cream would be ... Free with registration - Chemist & Druggist - AccessMyLibrary.com United States: Three Days In September: Generic Famvir® Temporarily … - Sep 28, 2007 Novartis had argued that other prior art taught away from using penciclovir by reporting toxicity of penciclovir in humans. The district court rejected this ... Mondaq News Alerts - Mondaq News Alerts (Registration) Fenistil Penciclovir - Oct 3, 2008 Voordat u met de therapie begint, raden wij u aan deze bijsluiter goed te lezen. Dit advies geldt ook als u iemand anders helpt met de toediening van ... Consumed What are the best treatments for herpes labialis?(CLINICAL INQUIRIES:... - Jul 1, 2007 Topical penciclovir 1% cream decreases the duration of lesion healing and ... In these cases, oral acyclovir or penciclovir cream can be prescribed for 4 ... $4.95 - Journal of Family Practice - ECNext [U] Novartis Pharmaceuticals Corp. v. Teva Pharmaceuticals USA, Inc.,... - Sep 6, 2007 Penciclovir is a member of the acyclic nucleosides group of compounds. ... Several prior art references described penciclovir as an effective anti-viral ... $2.95 - U.S. District Court, District of New... - VersusLaw Recent Developments in the Treatment of Cutaneous Viral Infections - Apr 17, 2006 Nucleoside analogues, including acyclovir, valacyclovir, penciclovir, and famciclovir, are currently the primary antiviral medications used in the ... Medscape PET imaging of thymidine kinase gene expression in the liver of non- … - Jul 31, 2008 ...cultured cells by positron emission tomography (PET) imaging when transduced cells are incubated with a fluoride-18 labelled penciclovir analogue. ... Nature.com Pharmacy Update: Coping with cold sores. - Apr 14, 2007 Aciclovir and penciclovir creams are more expensive than the combination products, ... creams containing the antiviral agents aciclovir and penciclovir. ... Free with registration - Chemist & Druggist - AccessMyLibrary.com Long-Term Monitoring of Transplanted Islets Using Positron Emission … - May 9, 2006 The amount of phosphorylated 8-[ 3 H]penciclovir was determined by separation from the unphosphorylated 8-[ 3 H]penciclovir using a DE-81 filter (Whatman). ... Nature.com Famvir: famciclovir tablets.(New indications) - Sep 1, 2006 A prodrug of penciclovir, famciclovir is ultimately phosphorylated by the viral thymidine ... Increased plasma concentrations of penciclovir may result from ... $4.95 - Formulary - ECNext Common oral lesions: Part I. Superficial mucosal lesions.(treating... - Feb 15, 2007 Effective treatment of herpes simplex labialis with penciclovir cream: combined results of two trials. J Am Dent Assoc 2002;133:303-9. ... $4.95 - American Family Physician - ECNext Treatment for Oral Herpes - Oct 1, 2006 Penciclovir (Denavir) heals HSV-1 sores on average about half a day faster than without treatment, stops viral shedding, and reduces the duration of pain. ... HealthCentral.com Transport's Phase 2 Data Show Single Treatment SoloVir(TM) ETS … - Nov 28, 2007 Currently approved treatments for herpes labialis, including acyclovir cream, penciclovir cream, n-docosonal 10 percent cream, valacyclovir, ... Free with registration - PR Newswire - AccessMyLibrary.com Cold sores | Life and style | BMJ Group - May 7, 2008 They include aciclovir (Zovirax) and penciclovir (Vectavir). But the research isn't clear on how well antiviral creams work. They may help cold sores heal a ... guardian.co.uk Clinical quiz. - Feb 15, 2007 A. Topical penciclovir (Denavir). [] B. Nystatin suspension (Mycostatin). [] C. Fluocinonide gel (Lidex). [] D. Zinc supplements. ... Free with registration - American Family Physician - AccessMyLibrary.com Infected with herpes virus? So are millions more - May 15, 2005 Acyclovir and penciclovir are available as ointments that also help decrease the time the herpes virus is shed. People with a history of herpes may infect ... Pay-Per-View - Chicago Tribune - ProQuest Archiver Article: Patient-initiated therapy speeds herpes healing.(Famciclovir... - May 1, 2006 2006 ; 700+ words ... ... symptoms, initiated therapy within an ... was 4.4 days in 152 patients ... the first day; and 6 ... to 0.6 days; penciclovir . ... Pay-Per-View - Internal Medicine News - HighBeam Research Putting cold sores on the run. - Sep 30, 2006 Penciclovir has been available on prescription since 1996 and is marketed as an OTC product in nine countries. Supporting the launch, national TV ... $9.94 - Chemist & Druggist - Alacra Store Clinical quiz. - Feb 15, 2007 A. Topical penciclovir (Denavir). [] B. Nystatin suspension (Mycostatin). [] C. Fluocinonide gel (Lidex). [] D. Zinc supplements. ... $4.95 - American Family Physician - ECNext Business Update; Barrier Therapeutics launches Denavir in Canada - Sep 26, 2006 Specially formulated for use on the lips and face, Denavir is a non-greasy cream that contains an antiviral agent, penciclovir, which is active against the ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones Cold sores are hard to keep under wraps - Feb 5, 2008 Treating sores with antiviral drugs, including acyclovir, valacyclovir, and penciclovir cream, can shorten their course by a day or two. ... Pay-Per-View - Orlando Sentinel - ProQuest Archiver Single-Day Famvir Treatment Found to Shorten the Duration of Recurrent... - Dec 18, 2005 Famvir, Pregnancy Category B, is contraindicated in patients with known hypersensitivity to the product, its components, or Denavir(R) (penciclovir cream). ... RedOrbit Cidofovir Modulated Gene Expression in Recurrent Respiratory … - May 30, 2005 ...other antiviral drugs ( acyclovir, penciclovir, and ganciclovir ), which have to be administered several times daily to sustain an antiviral response. ... i-newswire.com There's more to - Jun 4, 2005 The only effective treatment is creams containing the antiviral ingredients, acyclovir and penciclovir. These creams work best when applied to the skin at ... Daily Star - The Daily Star By the way, doctor; What can I do about cold sores?(herpes simplex... - Jan 1, 2005 Treating sores with antiviral drugs, including acyclovir, valacyclovir, and penciclovir cream can shorten their course by a day or two. ... Free with registration - Harvard Women's Health Watch - AccessMyLibrary.com Antiviral Medications For Herpes Treatment - Aug 22, 2008 Famciclovir is a prodrug for the active metabolite penciclovir. Famciclovir is converted into its active compound within the infected cell by contact with ... Buzzle One-day fight against herpes; New regimens can stop cold sore or... - Aug 14, 2006 An ointment for cold sores, Denavir (penciclovir), is also available. "This class of drugs, the nucleosides, is now the standard of care," says Dr. Stephen ... Pay-Per-View - Los Angeles Times - ProQuest Archiver Cutaneous small vessel vasculitis due to famciclovir therapy.(CASE … - Jul 1, 2005 Famciclovir is an oral prodrug of penciclovir and requires thymidine kinase to convert it into an active anti-viral agent. The half-life of famciclovir is ... Free with registration - Journal of Drugs in Dermatology - AccessMyLibrary.com Home | projo.com | The Providence Journal - Oct 1, 2006 An ointment for cold sores, Denavir (penciclovir), is also available. “This class of drugs, the nucleosides, is now the standard of care,â€? says Dr. Stephen ... Providence Journal Cidofovir Modulated Gene Expression in Recurrent Respiratory … - May 24, 2005 ...only once a week or every other week), which clearly distinguishes cidofovir from other antiviral drugs (acyclovir, penciclovir, and ganciclovir), ... newswise.com Therapie-Tagebuch Mir reicht's! - Jun 7, 2007 Nasenspray mit Meerwasser und Dexpanthenol, Bepanthensalbe gegen die roten Flecken, antibakterielle Mundspülung, Fettcreme für die Lippen, Penciclovir gegen ... Spiegel Online Comparative in vitro study on the anti-herpetic effect of phytochemica... - Jan 1, 2008 Only a few drugs are currently available for the treatment of HSV infections such as acyclovir or penciclovir. These substances belong to the synthetic ... Pay-Per-View - Phytomedicine: International Journal of... - HighBeam Research A ONE-DAY WALLOP FOR TREATING HERPES - Aug 22, 2006 An ointment for cold sores, Denavir (penciclovir), is also available. Over the years, doctors have learned that the medications can be taken in higher doses ... $2.95 - Miami Herald - NewsBank Florida Administrative Code - 64B8-36.003 Medicinal Drugs Which May … - Jul 5, 2005 ...(b) Penciclovir. Specific Authority 465.186(2) FS. Law Implemented 465.186 FS. History — New 5-1-86, Formerly 21M-39.003 , 61F6-39.003, 59R-36.003, ... Pay-Per-View - Florida Administrative Code - Loislaw Antivirale middelen bij Herpes simplex-virusinfecties - Nov 19, 2008 Voor lokaal toegepaste antivirale middelen (aciclovir, penciclovir) zijn de gegevens over doeltreffendheid tegenstrijdig: volgens sommige studies wordt de ... Gezondheid.be Clevudine (L-FMAU)--ç»?济--人民网 - Nov 20, 2006 ...在体外试验ä¸ï¼Œclevudine与emtricitabine, lamivudine, DAPD, adefovir dipivoxil å’Œpenciclovir具有å??å?Œä½œç”¨ã€‚ç»™æˆ?年美洲旱ç?，é?™è„‰æ³¨å°„25mg/kg clevudine， ... 人民网 Harvard Women's Health Watch Jan , 2005 - Jan 1, 2005 Treating sores with antiviral drugs, including acyclovir, valacyclovir, and penciclovir cream can shorten their course by a day or two. ... $4.95 - Harvard Women's Health Watch - ECNext Antivirale middelen bij Herpes simplex-virusinfecties - Jul 1, 2008 Voor lokaal toegepaste antivirale middelen (aciclovir, penciclovir) zijn de gegevens over doeltreffendheid tegenstrijdig: volgens sommige studies wordt de ... Belgisch centrum voor farmacotherapeutis... New dosing attacks herpes faster - Sep 4, 2006 An ointment for cold sores, Denavir (penciclovir), is also available. "This class of drugs, the nucleosides, is now the standard of care," says Dr. Stephen ... $2.95 - Fort Worth Star-Telegram - NewsBank Barrier Therapeutics Receives Regulatory Approval to Market Xolegel... - Mar 8, 2007 Denavir ® (penciclovir cream) Cream 1% for the treatment of herpes labialis (cold sores) in adults, and Solage ® (mequinol 2%, tretinoin 0.01%) Topical ... ccnmatthews.com Florida Administrative Code - 64B16-27.220 Medicinal Drugs Which May ... - Jul 5, 2005 ...(b) Penciclovir. Specific Authority 465.186(2) FS. Law Implemented 465.186 FS. History — New 5-1-86, Amended 10-7-90, Formerly 21S-18.003 , Amended 7-30-91, ... Pay-Per-View - Florida Administrative Code - Loislaw Antivirale middelen bij Herpes simplex-virusinfecties - Sep 29, 2008 In dit artikel wordt aandacht besteed aan de evidentie van doeltreffendheid van de antivirale middelen aciclovir, ganciclovir, penciclovir en valaciclovir, ... Medical facts Novartis: Strengthening Its Infectious Disease Portfolio - Feb 8, 2006 Currently, Novartis' ID portfolio consists of antivirals, including Famvir (famciclovir) and Denavir (penciclovir), and antifungals, specifically Lamisil ... RedOrbit Press Release: 50-80% of Americans Can Declare Their Independence … - Jul 7, 2005 ...sores and is currently under review by regulatory ... the herpes simplex virus, the cause of cold sores. Penciclovir is also the active ingredient ... ... Pay-Per-View - PR Newswire - HighBeam Research How to take Famciclovir from Consumer Reports Health. - Jan 9, 2007 ...tell your doctor and pharmacist if you are allergic to famciclovir, penciclovir cream (Denavir), acyclovir (Zovirax), any other medications, or lactose. ... consumerreports.org Imiquimod may clear superficial infantile hemangiomas.(Skin Disorders)... - Mar 15, 2005 Investigative formulations of two established antiviral agents--cidofovir and penciclovir--bear watching because of their dermatologic potential, ... Pay-Per-View - Family Practice News - HighBeam Research First-Time Generic Approvals: AccuNeb, Coreg, Famvir - Sep 28, 2007 Famciclovir is a prodrug of penciclovir, an antiviral agent that can be used topically for the treatment of herpes simplex labialis (cold sores). ... Medscape By the way, doctor; What can I do about cold sores?(herpes simplex... - Jan 1, 2005 Treating sores with antiviral drugs, including acyclovir, valacyclovir, and penciclovir cream can shorten their course by a day or two. ... Pay-Per-View - Harvard Women's Health Watch - Factiva, from Dow Jones FDA Approves Supplemental New Drug Application for Antiviral … - Jul 28, 2006 Famvir is Pregnancy Category B. Famvir is contraindicated in patients with known hypersensitivity to the product, its components, or Denavir(R) (penciclovir ... Free with registration - PR Newswire - AccessMyLibrary.com Single-Dose Famvir(R) Treatment Found To Accelerate Healing Time of … - Mar 3, 2006 Famvir, Pregnancy Category B, is contraindicated in patients with known hypersensitivity to the product, its components, or Denavir(R) (penciclovir cream). ... Free with registration - PR Newswire - AccessMyLibrary.com Statistically Significant Phase IIb Clinical Results of Transport's... - Aug 15, 2006 Currently approved treatments for herpes labialis are acyclovir cream, penciclovir cream, n-docosonal 10 percent cream, and the oral prodrug of acyclovir, ... Free with registration - PR Newswire - AccessMyLibrary.com FDA Approves Supplemental New Drug Application for Antiviral … - Jul 31, 2006 Famvir is Pregnancy Category B. Famvir is contraindicated in patients with known hypersensitivity to the product, its components, or Denavir® (penciclovir ... DG News Clinical Briefs By Louis Kuritzky, MD.(treatment of tick born... - Aug 15, 2006 ...herpes zoster, and mucocutaneous herpes infections in persons with HIV, the antiherpetic antivirals (acyclovir, famciclovir, penciclovir) do not have an ... Free with registration - Internal Medicine Alert - AccessMyLibrary.com Recurrent aphthous stomatitis - Feb 2, 2006 The use of topical aciclovir or penciclovir as early as possible can reduce the duration of herpes labialis. A sunscreen applied to the lips can also be ... Free with registration - Pulse - AccessMyLibrary.com Famciclovir for Herpes Labialis - Nov 29, 2006 ...including oral valacyclovir (2 g twice daily for 1 day), topical acyclovir, and penciclovir cream. Unfortunately, until such a study is conducted, ... Medscape In Brief: OTC antiviral mooted.(over the counter drugs)(Brief Article) - Jan 26, 2006 Patients would be advised to use penciclovir cream for cold sores for a maximum of four days before seeing a doctor under the proposals out for public ... Free with registration - Pulse - AccessMyLibrary.com OTC: Fenistil switches from POM to P. - Nov 18, 2006 With the cold sore market valued at #24.7 million and growing at 4.3 per cent, Novartis Consumer Health says the antiviral penciclovir cream offers ... Free with registration - Chemist & Druggist - AccessMyLibrary.com 5-FU cream well tolerated for superficial basal cell carcinoma.(Skin ... - May 1, 2005 Investigative formulations of two established antiviral agents--cidofovir and penciclovir--bear watching because of their dermatologic potential, ... Pay-Per-View - Family Practice News - HighBeam Research Harvard Women's Health Watch March , 2007 - Mar 1, 2007 So can topical acyclovir and penciclovir. We've heard from several readers who, like you, have had good luck using L-lysine. L-lysine, or simply lysine, ... $4.95 - Harvard Women's Health Watch - ECNext Prior antidepressant use predicts treatment adherence.(Mental Health)... - Oct 1, 2005 5 to 0.6 days; penciclovir ... 0.7 to 1 day, and docosanol ... efficient patient-initiated ... proportion of patients in the placebo ... every four patients ... Pay-Per-View - Family Practice News - HighBeam Research Press Release: Single-Dose Famvir(R) Treatment Found To Accelerate … - Mar 3, 2006 Penciclovir is also ... zoster) and recurrent genital herpes. In the two largest ... trials in patients with cold sores conducted to date, Denavir ... ... Pay-Per-View - PR Newswire - HighBeam Research Oregon Regulations - 850-060-0225 Naturopathic Formulary … - Feb 1, 2006 ...(276) Papavarine; (277) Paramethasone; (278) Paregoric; (279) Penciclovir; (280) Penicillamine (Board approved certification required before therapeutic ... Pay-Per-View - Oregon Regulations - Loislaw famciclovir Novartis, TAP licensing agreement. - Oct 9, 2006 Famciclovir is the inactive prodrug of penciclovir, which is effective against herpes simplex virus types 1 and 2, and is widely available for the ... Pay-Per-View - R & D Focus Drug News - Factiva, from Dow Jones Press Release: Transport Pharmaceuticals Initiates Patient Enrollment... - May 1, 2007 ...for herpes labialis (cold sores) was launched in the United Kingdom today by SmithKline Beecham (NYSE: SBH), the company said. Vectavir, penciclovir ... ... Pay-Per-View - PR Newswire - HighBeam Research Oregon Regulations - 850-060-0226 Naturopathic Formulary by … - Feb 1, 2006 ...(ii) Acyclovir; (iii) Didanosine; (iv) Emtricitabine; (v) Famciclovir; (vi) Ganciclovir; (vii) Lamivudine; (viii) Penciclovir; (ix) Stavudine; ... Pay-Per-View - Oregon Regulations - Loislaw PACIFIC BEACH BIO, DONG WHA PHARMA TO DEVELOP … - Aug 13, 2007 He has played a major role in the development of antibiotics (penicillins, cephalosporins, quinolones), antivirals (famciclovir, penciclovir, pleconaril), ... $4.95 - AsiaPulse News - ECNext Barrier to distribute Novartis' Denavir.(Barrier Therapeutics... - Mar 20, 2006 The USA's Barrier Therapeutics has acquired the exclusive Canadian marketing and distribution rights to topical cold sore drug Denavir (penciclovir cream) ... $4.95 - Pharma Marketletter - ECNext IN BRIEF: Reclassification of Vectavir. - Feb 15, 2006 Novartis Consumer Health has applied for a reclassification of Vectavir (penciclovir 1%) cold sore treatment from POM to P. It would be available in a 2g ... $4.95 - Community Pharmacy - ECNext ALPENKRAFT: Η «ΦΥΣΙΚΗ» ΛΥΣΗ - Dec 11, 2006 Η κÏ?Îμα Fenivir είναι Îνα φαÏ?μακευτικό σκεÏ?ασμα, που -χάÏ?η στη δÏ?αστική ουσία penciclovir- αντιμετωπίζει γÏ?ήγοÏ?α τον ιό που Ï€Ï?οκαλεί τον επιχείλιο ÎÏ?πητα. ... ΕλευθεÏ?οτυπία khoa hoc@doi song/Y Khoa Cap cuu so 17:Cac benh lay truyen bang … - Dec 5, 2007 ...nhiá»…m trùng có thể được Ä‘iá»?u trị bằng Ä‘Æ°á»?ng miệng vá»›i acyclovir, valacyclovir ( prodrug của acyclovir), hoặc famciclovir ( prodrug của penciclovir ). ... Khoa Há»?c Herpes genitalis - Dec 29, 2005 ...gilt die innerliche Behandlung mit solchen so genannten "Virustatika" mit den Wirkstoffen Aciclovir und Penciclovir als Mittel der Wahl. ... Apotheken Umschau Prevención y tratamiento de la neuralgia posherpética - Dec 10, 2007 Los resultados de los ensayos clÃnicos de famciclovir (prodroga de penciclovir) en el herpes zoster mostraron que éste fue de menor equivalencia en la ... Intramed.net - Intramed.net (Suscripción) Vraag en antwoord: koortslip - Sep 14, 2007 Wanneer je de koortslip bijtijds voelt opkomen, helpen vrij verkrijgbare crèmes met aciclovir (Zinolium, Zovirax, Previum) en penciclovir (Vectavir). ... Plusonline Herpes e Sole - Mar 31, 2005 Si tratta di pomate contenenti Aciclovir, Penciclovir o Idoxuridina da applicare localmente sulle lesioni ogni 4 ore per abbreviare il decorso della ... Lanciano Herpes labialis - Mar 13, 2006 Kremene Vectavir (inneholder penciclovir) og Zovirax (inneholder aciclovir) er likeverdige og skal smøres pÃ¥ det sÃ¥re omrÃ¥det fem ganger daglig i fem ... Lommelegen.no Voll auf die Lippe - Jan 9, 2006 Diese Produkte - wie auch sechs weitere - enthalten die Wirkstoffe Aciclovir oder Penciclovir. Sie sind unter allen eingesetzten Substanzen noch am ... Öko Test Fenivir:Για γÏ?ήγοÏ?η θεÏ?απεία του επιχείλιου ÎÏ?πητα - Mar 1, 2007 H κÏ?Îμα Fenivir είναι Îνα φαÏ?μακευτικό σκεÏ?ασμα που χάÏ?η στη δÏ?αστική ουσία penciclovir σταματά τον πολλαπλασιασμό και την εξάπλωση των ιών του απλοÏ? ÎÏ?πητα ... ΙατÏ?οnet Brand Names/Synonyms: Penciclovir is also known by the following brand names and/or synonymsDenavir; PE2; Penciclovir; Penciclovir [Usan:Ban:Inn]; Penciclovirum [Inn-Latin] Drug Category: Penciclovir is categorized under the following by the FDA: Antivirals; ATC:D06BB06; ATC:J05AB13 Dosage Forms: Topical cream Absorption: Measurable penciclovir concentrations were not detected in plasma or urine of healthy male volunteers (n= 12) following single or repeat application of the 1% cream at a dose of 180 mg penciclovir daily. Interactions: [an error occurred while processing this directive] Chemical IUPAC Name: 2-amino-9-[4-hydroxy-3-(hydroxymethyl)butyl]-3,9-dihydropurin-6-one |
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