Periactin

This page contains recent news articles, when available, and an overview of Periactin but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Periactin
(when available)

Pharmacology and use:
Cyproheptadine is a piperidine antihistamine. Unlike other antihistamines, this drug also antagonizes serotonin receptors. This action makes Cyproheptadine useful in conditions such as vascular headache and anorexia. Cyproheptadine does not prevent the release of histamine but rather competes with free histamine for binding at HA-receptor sites. Cyproheptadine competitively antagonizes the effects of histamine on HA-receptors in the GI tract, uterus, large blood vessels, and bronchial smooth muscle. Most antihistamines possess significant anticholinergic properties, but Cyproheptadine exerts only weak anticholinergic actions. Blockade of central muscarinic receptors appears to account for Cyproheptadine's antiemetic effects, although the exact mechanism is unknown. Cyproheptadine also competes with serotonin at receptor sites in smooth muscle in the intestines and other locations. Antagonism of serotonin on the appetite center of the hypothalamus may account for Cyproheptadine's ability to stimulate appetite. Cyproheptadine also has been used to counter vascular headaches, which many believe are caused by changes in serotonin activity, however it is unclear how Cyproheptadine exerts a beneficial effect on this condition. For treatment of perennial and seasonal allergic rhinitis, vasomotor rhinitis, allergic conjunctivitis due to inhalant allergens and foods, mild uncomplicated allergic skin manifestations of urticaria and angioedema, amelioration of allergic reactions to blood or plasma, cold urticaria, dermatographism, and as therapy for anaphylactic reactions adjunctive to epinephrine.

Mechanism Of Action:
Cyproheptadine competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding.

News Articles on Cyproheptadine

Periactin.(Drug overview)  -  Jan 22, 2007
Periactin is an antihistamine given to help relieve cold- and allergy-related symptoms such as hay fever, nasal inflammation, stuffy nose, red and inflamed ... Free with registration - PDR Family Guide to Prescription Drugs - AccessMyLibrary.com

MEDICINES RELIEVE ITCHING  -  Oct 21, 2007
Diphenhydramine (Benadryl), hydroxyzine (Vistaril) and cyproheptadine (Periactin) are examples of good anti-itch antihistamines. Write to Paul Donohue, ... Pay-Per-View - South Florida Sun - Sentinel - ProQuest Archiver

Federal Register 2006 - 71 FR 34940 Merck & Co., Inc., et al.;...  -  Jun 16, 2006
Injection --------------------------------------------------------------------- --------- NDA 13-220 Periactin (cyproheptadine Merck & Co., Inc. HCl) Syrup, ... Pay-Per-View - Federal Register 2006 - Loislaw

Does gaining 20lbs in a months time why takin 2periactin tablets a...  -  Sep 2, 2008
Are you taking Periactin on a doctor's recommendation? Are you taking Periactin for allergies? Or are you taking Periactin specifically to gain weight? ... HealthCentral.com

overwhelmed by new meds just downright scarede  -  Feb 5, 2008
Was taken off Cymbalta and Wellbutrin and am now taking Nardil and Periactin, (Periactin is in drug.com as dangerous to take with MAOI's, o goodie) this is ... HealthCentral.com

Dr Thomas Stuttaford answers your questions on hay fever  -  Jun 29, 2005
Phenergan promethazine hydrochloride, Periactin cyproheptadine hydrochloride, Vallergan alimemazipine tartrate, and Sudafed Plus tiprolidedine. ... Times Online

A Pill's Surprises, for Patient and Doctor Alike  -  Jan 25, 2005
Serotonin-blocking drugs like Periactin, an antihistamine, treat sexual side effects, but they can also undo the drugs' antidepressant effects. ... New York Times

Pharmacological management of secreting pituitary tumors.( …  -  Feb 1, 2007
...lab results Mitotane Lysodren 500 mg tablets 250-500 mg q hs Cyproheptadine Periactin 4 mg tablets 8-36 mg divided TID Growth Hormone-Secreting Adenomas ... Free with registration - Journal of Neuroscience Nursing - AccessMyLibrary.com

Foundation says doctors over-prescribing for kids  -  Dec 22, 2006
...five prescriptions contained medicines whose licenses have been revoked by the Department of Health, including cisapride, scanol, actifed and periactin. ... Taipei Times - Taipei Times

Namibia: New Info in Teek's Case  -  Apr 25, 2006
..."Whilst they were swimming, I went to lie on my bed as I had taken a Periactin tablet and had some beer to drink and I was extremely drowsy and sleepy." AllAfrica.com

Zimbabwe: Flea Markets Sell Dangerous Tablets  -  Jan 20, 2007
Dr Hove said the only body enhancing tablet she was aware of was Periactin, but it was no longer locally manufactured. "It is a pity that Zimbabwean women ... AllAfrica.com

St. Paul Pioneer Press : MANY MEDS DON'T MIX WITH THE SUN  -  Sep 21, 2005
Antihistamines: Cetirizine (Zyrtec), cyproheptadine (Periactin), diphenhydramine (Bena-dryl), loratadine (Claritin). Anti-malaria agents: Chloroquine ... $2.95 - St. Paul Pioneer Press - NewsBank

Pharmacological management of secreting pituitary tumors.( …  -  Feb 1, 2007
...lab results Mitotane Lysodren 500 mg tablets 250-500 mg q hs Cyproheptadine Periactin 4 mg tablets 8-36 mg divided TID Growth Hormone-Secreting Adenomas ... $4.95 - Journal of Neuroscience Nursing - ECNext

Xyzal--Just overpriced Zyrtec  -  Apr 4, 2008
An old drug, Periactin, is about all that works. Singulair was supposed to help a little, but doesn't reliably. Now comes Xyzal, telling us it's the best ... Gerson Lehrman Group

Can diabetic drug be cause of itching?  -  Jul 9, 2005
Atarax and Periactin have provided minimal relief. Do you have other suggestions? A Diabetes can lead to itchy skin conditions that are usually relieved by ... $2.95 - Erie Times-News - NewsBank

New views on headshaking  -  Jun 26, 2006
Another well-established treatment for the successful management of headshaking is the use of a combination of cryproheptadine (Periactin) and carbamazepine ... Thoroughbred Times

1/21/08 #6 - Five-year-old with Migraines 3 - 4 days a week?  -  Jan 21, 2008
With children her age, propranolol and periactin are often considered. If her doctor can't help you with this, consider consulting a pediatric Migraine ... HealthCentral.com

Migraine - Healthcare Republic News  -  Oct 28, 2005
Examples include tolfenamic acid (Clotam Rapid®), cyproheptadine (Periactin®), products containing ergot derivatives (eg, Cafergot®, Migril®) and Midrid® ... Healthcare Republic - Healthcare Republic

Adverse reactions associated with antidepressants in stroke patients.(...  -  Mar 1, 2006
...to serotonin syndrome also resolved with lorazepam (Ativan) and obviated the need of prescribing cyproheptadine (Periactin) as a serotonin antagonist. ... Free with registration - Brown University Geriatric Psychopharmac... - AccessMyLibrary.com

Allergy to cold weather: Is this possible?  -  Nov 20, 2007
Cyproheptadine (Periactin) may be especially useful for treatment of cold urticaria. Rarely, cold urticaria is associated with an inherited condition called ... MayoClinic.com

Generic name: Donepezil hydrochloride  -  Dec 1, 2005
...an allergic reaction to the drug itself, or an allergy to the group of antihistamines that includes Claritin, Allegra, Atarax, Periactin, and Optimine. ... Free with registration - PDR Family Guide to Prescription Drugs - AccessMyLibrary.com

Adverse Drug Reactions for the Emergency Physician: Part II  -  Jun 26, 2006
Although their effectiveness has not been demonstrated in prospective studies, cyproheptadine (Periactin), chlorpromazine (Thorazine), and methylsergide ... Free with registration - Emergency Medicine Reports - AccessMyLibrary.com

Malaysia Donates US $1 Million to WFP  -  Sep 15, 2005
Bisolvin Tablet (Bromhexine Hydrochloride IP 8mg), Diphenhydramine Capsules IP (diphenhydramine Hydrochloride IP 25mg), Periactin Tablet (Cyproheptadine ... Irrawaddy News Magazine - The Irrawaddy News Magazine

ANTIHISTAMINE (Oral route, Parenteral route, Rectal route).(Drug …  -  May 1, 2007
Periactin * Polaramine * Tavist * Unisom * Vistaril * Zaditor * Zymine * Zyrtec Brand names in the Canada -- * Allergy Formula Liquid ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Dr. Gott: 'Diabetic Itch' May Result From a Drug Allergy  -  Jul 12, 2005
Atarax and Periactin have provided minimal relief. Do you have other suggestions? Dear Reader: Diabetes can lead to itchy skin conditions that are usually ... RedOrbit

Should we use appetite stimulants for malnourished elderly patients?(...  -  Sep 1, 2007
Although a number of studies have evaluated various appetite stimulants--megestrol, dronabinol (Marinol), cyproheptadine (Periactin), thalidomide (Thalomid) ... Free with registration - Journal of Family Practice - AccessMyLibrary.com

Thuốc kháng histamin – Không thể dùng... bừa! - Tiêu dùng - Thể thao...  -  Oct 28, 2008
Hiện nay, nước ta vẫn dùng cyproheptadin (Periactin, Peritol) để trị chứng chán ăn. Nên lưu ý các đối tượng sau không được dùng cyproheptadin: ngư�i cao ... Thể thao văn hóa

Merger and Acquisition Scenario  -  Dec 16, 2006
Buyer (Total: 155). Periactin (Cyproheptadine HCl); Singulair (Montelukast Sodium); Prinivil (Lisinopril); Midamor (Amilore HCL) ... $250.00 - Revere Reports - Revere

Antidepressant-induced sweating.(Drug-Drug Interactions)  -  Jul 1, 2005
Use of other medications including cyproheptadine (Periactin) at doses of 4 mg once or twice daily, and clonidine (Catapres, Duraclon) 0.1 mg twice daily ... Free with registration - Brown University Geriatric Psychopharmac... - AccessMyLibrary.com

Sun Herald : Photosensitive medicines listed  -  Aug 23, 2007
Antihistamines: cetirizine (Zyrtec); cyproheptadine (Periactin); diphenhydramine (Benadryl); loratadine (Claritin). Anti-malaria agents: chloroquine ... $2.95 - Sun Herald - NewsBank

Merger and Acquisition Scenario  -  Apr 15, 2006
Buyer (Total: 136). Periactin (Cyproheptadine HCl); Singulair (Montelukast Sodium); Prinivil (Lisinopril); Midamor (Amilore HCL) ... $250.00 - Revere Reports - Revere

Merger and Acquisition Scenario  -  Aug 19, 2006
Target (Total: 154). Periactin (Cyproheptadine HCl); Singulair (Montelukast Sodium); Prinivil (Lisinopril); Midamor (Amilore HCL) ... $250.00 - Revere Reports - Revere

Press of Atlantic City, The : Question & Answer from the pharmacy:...  -  Aug 27, 2007
Antihistamines: cetirizine (Zyrtec); cyproheptadine (Periactin); diphenhydramine (Benadryl); loratadine (Clar-itin). - Anti-malaria agents: chloroquine ... $2.95 - Press of Atlantic City, The - NewsBank

Migraines & women.(AGES & STAGES)  -  Jun 1, 2005
...beta blockers such as propranolol (Inderal), calcium blockers such as verapamil, and the antihistamine cyproheptadine (Periactin) in children. (23) ... $4.95 - National Women's Health Report - ECNext

Loislaw Federal District Court Opinions - GARCIA v. EGAN (EDTex. 2006)  -  Jun 27, 2006
In October of 2004, Garcia was seen for complaints of chronic nasal congestion, for which he received an antihistamine called periactin. ... Pay-Per-View - Loislaw Federal District Court Opinions - Loislaw

Merger and Acquisition Scenario  -  Jan 27, 2007
Buyer (Total: 158). Periactin (Cyproheptadine HCl); Singulair (Montelukast Sodium); Prinivil (Lisinopril); Midamor (Amilore HCL) ... $250.00 - Revere Reports - Revere

Merger and Acquisition Scenario  -  Oct 21, 2006
Target (Total: 156). Periactin (Cyproheptadine HCl); Singulair (Montelukast Sodium); Prinivil (Lisinopril); Midamor (Amilore HCL) ... $250.00 - Revere Reports - Revere

Keppra.(New & Approved) | Article from Pediatric News | HighBeam …  -  Aug 1, 2005
Pediatric News; February 1, 2005 ; 700+ words ... ... cyproheptadine (Periactin), amitriptyline (Elavil), divalproex sodium (Depakote), topiramate (Topamax) ... Pay-Per-View - Pediatric News - HighBeam Research

Merger and Acquisition Scenario  -  Nov 25, 2006
Buyer (Total: 156). Periactin (Cyproheptadine HCl); Singulair (Montelukast Sodium); Prinivil (Lisinopril); Midamor (Amilore HCL) ... $250.00 - Revere Reports - Revere

DIABETIC ITCH MAY BE RESULT OF ALLERGY  -  Jul 29, 2005
Atarax and Periactin have provided minimal relief. Do you have other suggestions? Dear Reader: Diabetes can lead to itchy skin conditions that are usually ... $2.95 - The Tribune - NewsBank

Merger and Acquisition Scenario  -  Mar 11, 2006
Buyer (Total: 137). Periactin (Cyproheptadine HCl); Singulair (Montelukast Sodium); Prinivil (Lisinopril); Midamor (Amilore HCL) ... $250.00 - Revere Reports - Revere

Phòng và Ä‘iá»?u trị các bệnh ngứa da  -  Jan 16, 2007
...xoa thuốc giảm ngứa, ngừa rỉ nước như calamine, kem hydrocortisone 1%. Có thể dùng thuốc uống chống histamine như Benadryl, Atarax, Periactin. VNMedia

Merger and Acquisition Scenario  -  Aug 19, 2006
Buyer (Total: 154). Periactin (Cyproheptadine HCl); Singulair (Montelukast Sodium); Prinivil (Lisinopril); Midamor (Amilore HCL) ... $250.00 - Revere Reports - Revere

.: KHOA HOC PHO THONG :.  -  Feb 16, 2005
Thuốc phải đặc biệt lưu ý không dùng bừa bãi là cyproheptadin (Periactin, Peritol). Ä?ây là thuốc kháng histamin trị dị ứng nhưng có thêm tác dụng kích thích ... Khoa Há»?c Phổ Thông

Merger and Acquisition Scenario  -  Aug 19, 2006
Target (Total: 154). Periactin (Cyproheptadine HCl); Singulair (Montelukast Sodium); Prinivil (Lisinopril); Midamor (Amilore HCL) ... $250.00 - Revere Reports - Revere

Leucoencefalopatía multifocal progresiva (LMP)  -  Sep 20, 2005
Los medicamentos cyproheptadine (Periactin) y mirtazapine (Remeron), usados típicamente para el control de los síntomas psicóticos como las alucinaciones y ... AIDSmeds.com HIV/AIDS Treatment News

Merger and Acquisition Scenario  -  Dec 16, 2006
Buyer (Total: 155). Periactin (Cyproheptadine HCl); Singulair (Montelukast Sodium); Prinivil (Lisinopril); Midamor (Amilore HCL) ... $250.00 - Revere Reports - Revere

Merger and Acquisition Scenario  -  May 13, 2006
Buyer (Total: 136). Periactin (Cyproheptadine HCl); Singulair (Montelukast Sodium); Prinivil (Lisinopril); Midamor (Amilore HCL) ... $250.00 - Revere Reports - Revere

Merger and Acquisition Scenario  -  Jun 24, 2006
Target (Total: 155). Periactin (Cyproheptadine HCl); Singulair (Montelukast Sodium); Prinivil (Lisinopril); Midamor (Amilore HCL) ... $250.00 - Revere Reports - Revere

Merger and Acquisition Scenario  -  Nov 4, 2006
Buyer (Total: 156). Periactin (Cyproheptadine HCl); Singulair (Montelukast Sodium); Prinivil (Lisinopril); Midamor (Amilore HCL) ... $250.00 - Revere Reports - Revere

Merger and Acquisition Scenario  -  Sep 2, 2006
Buyer (Total: 154). Periactin (Cyproheptadine HCl); Singulair (Montelukast Sodium); Prinivil (Lisinopril); Midamor (Amilore HCL) ... $250.00 - Revere Reports - Revere

兒童用藥抽檢八æˆ?有å•?題  -  Dec 21, 2006
...進一步分�,竟還發�5張藥單出�已被衛生署註銷許�證的Cisapride�Scanol�Actifed�Periactin 等藥物;其中,Cisapride更早在2年�,因國內外�出�死亡案例,而被 ... epochtimes.com

Tương Tác giữa Thá»±c Phẩm và Dược Phẩm  -  Oct 22, 2005
Thuốc làm tăng sự thèm ăn như Cyproheptadine ( Periactin) giúp ăn ngon hơn và tăng sức nặng cho cơ thể. Ngược lại, thuốc Amphetamine lại làm giảm sự thèm ăn ... Hướng Dương

Khi nào nên cho trẻ biếng ăn sá»­ dụng thuốc?  -  Nov 17, 2006
Tiến sÄ©-bác sÄ© Phạm Gia Tiến nhấn mạnh, vá»›i nhóm thuốc cyproheptadine (có biệt dược là Peritol hay Periactin, Dynamogen...) nếu dùng quá liá»?u sẽ gây buồn ... Ngưá»?i Lao Ä?á»™ng

Leucoencefalopatía multifocal progresiva (LMP)  -  Jul 6, 2006
Los medicamentos cyproheptadine (Periactin®) y mirtazapine (Remeron®), usados típicamente para el control de los síntomas psicóticos como las alucinaciones ... AIDSmeds.com HIV/AIDS Treatment News

Brand Names/Synonyms:
Periactin is also known by the following brand names and/or synonymsCypoheptadine; Cyproheptadiene; Cyproheptadine; Cyproheptadine Hcl; Dibenzosuberonone/Cyproheptadine; Dronactin; Eiproheptadine; MK 141; Periactin; Periactine; Periactinol; Peritol

Drug Category:
Periactin is categorized under the following by the FDA: Anti-allergic Agents; Gastrointestinal Agents; Antipruritics; Antihistamine derivatives; ATC:R06AX02

Dosage Forms:
SYRUP;TABLET

Absorption:
Well absorbed after oral administration.

Interactions:
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Chemical IUPAC Name:
Not Available





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