Phenobarbital

This page contains recent news articles, when available, and an overview of Phenobarbital but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Phenobarbital
(when available)

Pharmacology and use:
Phenobarbital, the longest-acting barbiturate, is used for its anticonvulsant and sedative-hypnotic properties in the management of all seizure disorders except absence (petit mal). For the treatment of Epilepsy

Mechanism Of Action:
Phenobarbital acts on GABAA receptors, increasing synaptic inhibition. This has the effect of elevating seizure threshold and reducing the spread of seizure activity from a seizure focus. Phenobarbital may also inhibit calcium channels, resulting in a decrease in excitatory transmitter release. The sedative-hypnotic effects of phenobarbital are likely the result of its effect on the polysynaptic midbrain reticular formation, which controls CNS arousal.

News Articles on Phenobarbitone

SJS Dilantin: Wrongful Death Lawsuit  -  05 Jan 2010
..."At first she was on Phenobarbital, but it turned her into a Jekyll and Hyde so we insisted she get another medication," says Randy, her father. ... Lawyers and Settlements

History of Now: The Story of the Noughties  -  05 Jan 2010
...whether you're going to be able to cram yourself on an EasyJet to Zurich where a man will give you a beaker of sodium phenobarbital and you'll die. ... The Guardian

Taro seeks to develop epilepsy treatment  -  ‎Dec 21, 2009‎
The company said animal testing had shown DPB to be as effective as Phenobarbital, which remains the most commonly prescribed drug for epilepsy in the world ... Drug Store News (blog)

So what's in your nonenergy drink?  -  ‎Dec 29, 2009‎
Examples include benzodiazepines such as lorazepam (Ativan) or diazepam (Valium), barbiturates such as phenobarbital, narcotics such as codeine, ... Los Angeles Times (blog)

Rita Watson: A new medical relationship: Physicians, healers, botanicals  -  ‎Jan 2, 2010‎
...be locally available, sustainable, low-cost and better tolerated than drugs more typically available in developing countries, such as phenobarbital. ... Providence Journal

Hard choice for a comfortable death: drug-induced sleep  -  ‎Dec 27, 2009‎
The sedation drugs are lorazepam, midazolam, phenobarbital and, in the intensive care unit only, sodium thiopental. For pain, the guidelines list opioid ... Chattanooga Times Free Press

Understanding epilepsy: one woman's story  -  ‎Dec 15, 2009‎
Gross was prescribed dilanthum and phenobarbital at first, followed by 18 other drugs. Not only did these not work, but also the meds made her behavior ... Times Herald-Record

Taro Announces Clinical Trials with T2007, Its Second Proprietary Non-Sedating ...  -  ‎Dec 18, 2009‎
In animal models, DPB has efficacy comparable to phenobarbital, a long-established clinical treatment for epilepsy. Phenobarbital remains the most commonly ... FOXBusiness

Taro initiates Phase I trials for non-sedating barbiturate drug in Canada  -  ‎Dec 23, 2009‎
In animal models, DPB has efficacy comparable to phenobarbital, a clinical treatment for epilepsy. Republication or redistribution, including by framing or ... Trading Markets (press release)

Ask a Vet: What do I do when my dog has seizures?  -  ‎Dec 11, 2009‎
Medications commonly used in dogs to reduce the occurrence of seizures are phenobarbital and potassium bromide. If these don't control the seizures either ... Annapolis Capital

Showdown at Commission of Inquiry – Fabro maintains innocence; Sosa says ...  -  ‎Dec 23, 2009‎
...(Dr. Sosa's specialization is neurology, and according to him, fentanyl, phenobarbital, Dilantin, and valproic acid - items he called “front-line� ... Amandala

Acetaminophen is safe when used as recommended  -  14 Nov 2009
Alcohol and some prescription drugs, such as Phenobarbital, may actually increase the potential for acetaminophen toxicity. Since acetaminophen is not ... Winfield Daily Courier Online

Epilepsy treatments to be studied  -  ‎Oct 20, 2009‎
Guillermo Palchik, a doctoral student at the centre's paediatric department, said: "We know that early-life exposure to AEDs such as Phenobarbital triggers ... The Press Association

Epilepsy drugs may cause schizophrenia  -  ‎Oct 22, 2009‎
..."We know that early-life exposure to (anti-epileptic drug treatments) such as Phenobarbital triggers cell death in many brain regions associated with the ... United Press International

Margaux Hemingway: The Movie  -  ‎Nov 6, 2009‎
She was found in her Santa Monica apartment and died from an overdose of Phenobarbital. "She rose to fame too quickly. It was all too much for this girl ... PerezHilton.com (blog)

Seizure Meds May Up Risk of Mental Disorders  -  ‎Oct 23, 2009‎
...“We know that early-life exposure to AEDs such as phenobarbital triggers cell death in many brain regions associated with the onset of schizophrenia,� ... PsychCentral.com

Scientists Reveal A New Mechanism That Increases Atherosclerosis In Mice  -  ‎Nov 6, 2009‎
...the antiretroviral drug ritonavir for HIV treatment and the antiepileptic drugs carbamazipine and phenobarbital, all of which activate PXR. ... Science Daily (press release)

Treatment of epilepsy could be likely reason for growth of Schizophrenia  -  ‎Oct 28, 2009‎
Guillermo Palchik, a doctoral student in the department of pediatrics at GUMC, commented, “We know that early-life exposure to AEDs such as Phenobarbital ... HealthJockey.com

BioIdentical Hormone Disinformation From AP Medical Writer, Marilynn Marchione  -  ‎Nov 12, 2009‎
Two examples are phenobarbital, an anti-convulsant, and chloral-hydrate, a sedative. So, don't do anything impulsive or crazy to remove these non-FDA ... OpEdNews

Ask Dog Lady: Dog seems to pine for her owners  -  ‎Nov 6, 2009‎
You never explain why wee Willie is on Phenobarbital. Anyway, Dog Lady is not a vet, nor does she play one on the pages of this newspaper. ... Daily News Tribune

Suspects in court on drug charges  -  ‎Nov 1, 2009‎
TK, 21, and SM, 18, were accused of possessing heroin, diazepam and phenobarbital and attempting to smuggle them into Bur Dubai police station last April. ... National

New mechanism apparently increases atherosclerosis in mice  -  ‎Nov 9, 2009‎
...taken for tuberculosis treatment, the antiretroviral drug ritonavir for HIV treatment and the antiepileptic drugs carbamazipine and phenobarbital. ... HealthJockey.com

A father's heartbreak  -  ‎Nov 3, 2009‎
..."It was controlled by only one kind of medicine, called phenobarbital. When he came here, he continued to have seizures, and more often. ... TheChronicleHerald.ca

Novartis drug Tasigna(R) meets primary endpoint in pivotal trial against ...  -  ‎Oct 19, 2009‎
...dexamethasone, phenytoin, carbamazepine, rifampin, rifabutin, rifapentin, phenobarbital). Patients should also refrain from taking St John's Wort. ... Reuters

Milford woman arrested in drug trafficking case  -  ‎Oct 26, 2009‎
A subsequent search of Donovan turned up three kinds of drugs for which he had no proof of a prescription, namely the anticonvulsant phenobarbital, ... Bangor Daily News

Folate Thought to Prevent Neural Tube Defects in Newborns  -  ‎Oct 24, 2009‎
...calcium channel blockers,cimetidine, Bactrim (septra), and certain anti-seizure medications such as phenobarbital, phenytoin, tegretol ,primidone, ... PR-CANADA.net (press release)

Pharmaceutical Journal - Avoid folic acid antagonists in first trimester of ...  -  ‎Oct 20, 2009‎
Other folic acid antagonists, which are known to reduce serum and tissue concentrations of folate, such as carbamazepine, valproic acid, phenobarbital, ... DeHavilland (press release) (subscription)

Vida de Margaux Hemingway será llevada al cine  -  ‎Nov 8, 2009‎
Tras sufrir varias etapas depresivas y de luchar contra sus adicciones, Margaux decidió quitarse la vida con una sobredosis de Phenobarbital, ... El Universal (México)

å…©å??中國人在符拉迪沃斯托克因銷售å?±éšªæ¸›è‚¥è—¥è¢«ç½°æ¬¾  -  ‎Oct 26, 2009‎
...他進一步指出,這兩å??中國人還å?‘消費者推薦一種å??為ã€?爸爸-媽媽〞的藥片,該藥物å?«æœ‰å¤§åŠ‘é‡?苯巴比妥(Phenobarbital),這是一種和西布曲明有關的烈性物質,如長期 ... 鉅亨網

两å??中国人在俄售å?–å?±é™©å‡?è‚¥è?¯è¢«åˆ¤åˆ‘  -  ‎Oct 27, 2009‎
...他进一步指出,这两å??中国人还å?‘消费者推è??一ç§?å??为“爸爸-妈妈â€?çš„è?¯ç‰‡ï¼Œè¯¥è?¯ç‰©å?«æœ‰å¤§å‰‚é‡?苯巴比妥(Phenobarbital),这是一ç§?和西布曲明有关的烈性物质,如长期æœ?用, ... 南方报网

What's the evidence for phenobarbital?  -  Dec 4, 2008
There is reasonably good evidence that taking phenobarbital helps to stop or reduce seizures for many people. The studies we found compared phenobarbital ... guardian.co.uk

… -Controlled Trial of Prophylactic Oral Phenobarbital to Reduce the...  -  Feb 17, 2005
The role of enzyme inducers, like phenobarbital, in G6PD deficiency is unclear. ... Rh isoimmunization, maternal Phenobarbital use and lack of parental ... Nature.com

Phenobarbital for epilepsy  -  Oct 29, 2007
Phenobarbital requires one dose each day for most people. Infants may need two doses. Phenobarbital is available in liquid, capsule, and tablet forms. ... WebMD

NKCC1 transporter facilitates seizures in the developing brain  -  Oct 9, 2005
...(c) Ictal-tonic discharges in the CA3 pyramidal cell layer of P12 rat hippocampal slice are potentiated by phenobarbital (100 M), consistent with the lack ... Nature.com

A Randomized Controlled Trial of Phenobarbital in Neonates With …  -  Jan 26, 2006
By Singh, Daljit; Kumar, Praveen; Narang, Anil. Background. Phenobarbital is one of the oldest, cheapest and most easily available cerebro-protective drugs ... RedOrbit

Small price to pay to stop epilepsy seizures  -  Jun 8, 2007
The least expensive of these medications, phenobarbital, has been recommended by the World Health Organisation (WHO) for victims of convulsive seizures in ... Independent Online

Theophylline, Ephedrine, Guaifenesin, and Phenobarbital ( Systemic).  -  Jul 28, 2005
Theophylline, ephedrine, guaifenesin, and phenobarbital (fee-noe-BAR-bi-tal) combination is used to treat the symptoms of bronchial asthma, ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Theophylline, Ephedrine, and Phenobarbital (Systemic).  -  Oct 27, 2005
Theophylline, ephedrine, and phenobarbital (thee-OFF-i-lin, e-FED-rin, and fee-noe-BAR-bi-tal) combination is used to treat the symptoms of bronchial asthma ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Dallas Morning News | News for Dallas, Texas | Texas/Southwest  -  Oct 16, 2006
An autopsy report showed Severance died from acute drug intoxication caused by pentobarbital and phenobarbital, drugs commonly used to euthanize animals. ... Dallas Morning News

Phenobarbital.(Drug overview)  -  Dec 1, 2005
Phenobarbital, a barbiturate, is used as a sleep aid and in the treatment of certain types of epilepsy, including generalized or grand mal seizures and ... Free with registration - PDR Family Guide to Prescription Drugs - AccessMyLibrary.com

phenobarbital -- Britannica Online Encyclopedia  -  Jun 20, 2008
Britannica online encyclopedia article on phenobarbital: barbiturate drug that became available in 1912, used in medicine as a sedative-hypnotic. Subscription - Encyclopedia Britannica

Phenobarbital overdose claimed in suit against pharmacy  -  Jul 17, 2007
By Ann Knef -Belleville Bureau. A Washington Park pharmacy is being sued by a woman who claims a druggist provided the wrong dosage of an anti-seizure ... Madison County Record

Barbiturates, Aspirin, and Codeine (Systemic).(Drug overview)  -  May 1, 2006
Butalbital and phenobarbital belong to the group of medicines called barbiturates. ... (For butalbital or phenobarbital): Barbiturates pass into the breast ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Effects of Diphenylhydantoin, Phenobarbital, and Diazepam on the …  -  Dec 1, 2008
The metabolic clearance rates (MCR) of methylprednisolone (MP) (no. = 13) and methylprednisolone-21-Na-hemisuccinate (MPHS) (no. = 6) were studied in normal ... Journal of Clinical Endocrinology and...

Making some changes for the good of games.(Shaquille O'Neal is...  -  May 28, 2005
While reading the following offers no guarantees, it is cheaper than psychotherapy and probably safer than an overdose of Phenobarbital, yet with many of ... Free with registration - Miami Herald - AccessMyLibrary.com

Nurses Recall A Kind, Cruel, Strange Era .  -  May 23, 2005
...that was before we had tranquilizers," Marie Nichols Sonn said. had phenobarbital and barbiturates, electric shock and in sulin shock therapy. ... St. Petersburg Times - Google News Archive

New anticonvulsant drugs show promise in dogs, cats  -  Mar 1, 2008
In most cases, it is used to avoid the side effects of phenobarbital or potassium ... Levitiracetam has been used as an add-on (to phenobarbital) oral ... DVM 360

… States Code of Federal Regulations - 21 CFR § 862.3660 Phenobarbita...  -  Jul 11, 2006
21 CFR § 862.3660 Phenobarbital test system. (a) Identification. A phenobarbitol test system is a device intended to measure phenobarbital, an antiepileptic ... Pay-Per-View - United States Code of Federal Regulation... - Loislaw

Phenobarbital.(Pediatric Advisor 2007)(Drug overview)(Brief article)  -  May 31, 2007
Phenobarbital is a medicine used in children to prevent seizures. It may also be used to treat jaundice (yellowing of skin and eyes due to a very high level ... $4.95 - Clinical Reference Systems - ECNext

… ; Alcohol withdrawal therapy is equally effective with phenobarbital...  -  Apr 4, 2006
..."Gabapentin was compared with phenobarbital for the treatment of alcohol withdrawal in a randomized, open-label, controlled trial in 27 inpatients. ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

phenobarbital | Definition of phenobarbital | HighBeam.com: Online …  -  Jul 12, 2006
Find out what phenobarbital means: The Oxford American College Dictionary has the definition of phenobarbital. Research related newspaper, magazine, ... Pay-Per-View - Oxford American College Dictionary - HighBeam Research

Code of Massachusetts Regulations - 105 CMR 701.002: Excepted …  -  Feb 20, 2007
Ephedrine and Tablet: Sodium phenobarbital, The Vale Chemical sodium 1/4 gr.; ... Ephedrine sulfate Tablet: Phenobarbital, 15 The Zemmer Co. and ephedrine ... Pay-Per-View - Code of Massachusetts Regulations - Loislaw

Georgia Code - 16-13-29.1. The following nonnarcotic substances which...  -  Aug 4, 2005
Racephedrine/25.00 mg Amodrine E C Phenobarbital/8.00 mg; Searle, ... Theophylline/130.00 mg Teephen Phenobarbital/4.00 mg/05 Robinson ... Pay-Per-View - Georgia Code - Loislaw

Phenobarbital.(Pediatric Advisor 2006)(Brief article)  -  Nov 1, 2006
Phenobarbital is a medicine used in children to prevent seizures. It may also be used to treat jaundice (yellowing of skin and eyes due to a very high level ... $4.95 - Clinical Reference Systems - ECNext

She had a wonderful heart but a bad mind, and the two conflicted."  -  Sep 15, 2005
Helen Jean ordeman-pratt most likely overdosed on Benadryl and the dog's phenobarbital. it's obvious she took her own life," he said in a telephone inter ... Eugene Register-Guard - Google News Archive

Drugs that affect liver enzyme interpretation.  -  May 1, 2006
Corticosteroids and phenobarbital therapy have been associated with both ... (1-4) Given the frequency of corticosteriod and phenobarbital use in clinical ... Free with registration - Veterinary Medicine - AccessMyLibrary.com

Code of Massachusetts Regulations - 105 CMR 701.001: Excluded Non- …  -  Feb 20, 2007
Phenobarbital, 4 mg.; ephedrine hydrochloride, 12 mg.; theophylline, 65 mg. Tedral suppositories double Suppository: Phenobarbital, 16 Do. strength mg.; ... Pay-Per-View - Code of Massachusetts Regulations - Loislaw

Fosters.com - Dover NH, Rochester NH, Portsmouth NH, Laconia NH, …  -  May 27, 2005
Police searched Davidson's clinic, Advanced Animal Care, and found records that showed she had administered phenobarbital to a dog. However, the dog's owner ... Foster's Daily Democrat

Mother convicted of trying to kill disabled child  -  Nov 15, 2006
The Pekin woman told investigators she fed her then 4-year-old child sleeping pills and Phenobarbital on June 21 in hopes of ending the girl's suffering. ... The Southern

Hormone Receptors; Phenobarbital response unit studied, binding sites...  -  Aug 19, 2005
2005 AUG 19 - (NewsRx.com) -- According to recently published research from Canada, the CYP2B2 phenobarbital (PB) response unit (PBRU) contains binding ... Pay-Per-View - Drug Week - Factiva, from Dow Jones

Kentucky Regulations - 902 KAR 55:045. Exempt prescription products.  -  Aug 10, 2005
NDC 00115-2156: phenobarbital 15 mg; (7) Aminophylline and Phenobarbital Tablets, ... sustained release tablet, NDC 00078-0027: phenobarbital 50 mg; ... Pay-Per-View - Kentucky Regulations - Loislaw

Can antiepileptic drugs unmask a susceptibility to psychiatric...  -  Nov 18, 2008
...(1987) Phenobarbital treatment and major depressive disorder in children with epilepsy. Pediatrics 80: 909–917 | PubMed | ChemPort | ... Nature.com

Should patients with epilepsy be routinely screened for low bone...  -  Feb 14, 2008
Variables associated with low BMD included older age or menopause in women, duration of therapy, and a history of phenytoin or phenobarbital use. ... Nature.com

Illinois Administrative Code - 77 Ill. Adm. Code 2070.2310 Phenobarbit...  -  Aug 10, 2005
77 Ill. Adm. Code 2070.2310 Phenobarbital Phenobarbital. Copyright © 2008 Loislaw.com, Inc. All Rights Reserved. Pay-Per-View - Illinois Administrative Code - Loislaw

United States Code of Federal Regulations - 21 CFR § 1308.22 Excluded...  -  Jul 11, 2006
Bioline Laboratories Theophed 00719-1945 TB Phenobarbital 8.00 Classic ... 00182-1377 EL Phenobarbital 4.00 Goldline Laboratories Tedrigen Tablets ... Pay-Per-View - United States Code of Federal Regulation... - Loislaw

Toxicology Tests On Dead Airman Lead To Search Of Veterinary Clinic .  -  Apr 15, 2005
The also found a similar drug called phenobarbital, court ecords show. ... Department of Public Safety offi cers took four of phenobarbital tablets from ... Victoria Advocate - Google News Archive

[U] Lewis v. Monumental Life Insurance Co., No. 2006-CA-000914-MR ( …  -  Apr 20, 2007
Flathers' death certificate provides that her death was an accident based upon the underlying cause of Phenobarbital toxicity. In addition, James David ... $2.95 - Kentucky Court of Appeals - VersusLaw

… Code 790.1423 ATROPINE SULFATE; HYOSYAMINE; PHENOBARBITAL …  -  Aug 10, 2005
77 Ill. Adm. Code 790.1423 ATROPINE SULFATE; HYOSYAMINE; PHENOBARBITAL; SCOPOLAMINE HYDROBROMIDE (Repealed) Repealed. (Source: Repealed at 17 Ill. Reg. ... Pay-Per-View - Illinois Administrative Code - Loislaw

Indiana Administrative Code - 856 IAC 2-2-8 Excepted stimulant or …  -  Aug 9, 2005
Aminodrox with ___________ Tablet: Phenobarbital, The S.E. Massengill ... Aminodrox-forte __________ Tablet: Phenobarbital, 15 The S.E. Massengill with ... Pay-Per-View - Indiana Administrative Code - Loislaw

Pet store neglect, ear-cropping  -  Jan 4, 2005
The officers said they found phenobarbital, surgical blades and a garbage can containing two sets of dog ears wrapped in a newspaper, Cotterell said. ... Pet-Abuse.Com

Todd's Story | Article from Oakland Tribune | HighBeam Research  -  Jun 30, 2006
Switching medications Todd's dosage of phenobarbital was lowered on Feb. ... Three days after Sanders first reduced Todd's dosage of phenobarbital, ... Pay-Per-View - Oakland Tribune - HighBeam Research

SUSPECT'S FIRE STORY BELIES INTENT, PROSECUTOR SAYS  -  Jun 30, 2005
...suffering from a spinal tumor and heavily sedated with what a medical examiner said was a near lethal dose of phenobarbital. ... Pay-Per-View - Palm Beach Post - NewsBank

Indiana Administrative Code - 856 IAC 2-2-10 Excluded nonnarcotic …  -  Aug 9, 2005
Suspension Phenobarbital, 4 mg.; ephedrine hydrochloride, 12 mg.; theophylline, 65 mg. Tedral suppositories _____ Suppository: Phenobarbital, Do. double ... Pay-Per-View - Indiana Administrative Code - Loislaw

Kentucky Regulations - 902 KAR 55:040. Excluded over-the-counter …  -  Aug 10, 2005
...tablet, NDC code 00349-2018: phenobarbital 8.10 mg.; (2) Azma-Aids ®, tablet, NDC code 00367-3153: phenobarbital 8 mg; (3) Bronkolixir ®, elixir, ... Pay-Per-View - Kentucky Regulations - Loislaw

In 'Mad Men, '60s treatment of high blood pressure seems advanced  -  Aug 11, 2008
Phenobarbital was commonly used to treat hypertension and stress, and 1960s doctors were aware that stress contributed to elevated blood pressure. ... Los Angeles Times

苯巴比妥(phenobarbital)  -  May 13, 2006
...它是长效的镇�催眠剂,因是酶诱导剂,在�病时�用于退黄。 作用机制:(1)诱导脲 嘧啶二磷酸葡�糖醛酸转移酶,促使胆红素与葡�糖醛酸结�,加速其从肠�和尿中 ... ��

WHO model list of essential medicines 15th edition, revised March...  -  Mar 22, 2007
...convulsant disorders. phenobarbital Injection: 200 mg/ml (phenobarbital ... 15 mg/5 ml (phenobarbital) or 5 ml (phenobarbital sodium) Tablet: 15-100 mg ... Free with registration - WHO Drug Information - AccessMyLibrary.com

Má»™t há»?c sinh ngá»™ độc vì uống thuốc trị tâm thần  -  Mar 7, 2008
Qua kiểm tra số thuốc ngư�i nhà đem vào, các bác sỹ phát hiện viên thuốc Phenobarbital 0100g màu hồng mà cô của em đang dùng để trị bệnh tâm thần giống như ... cand.com

Три наркокурьера приговорены к Ñ?мертной казни во Вьетнаме  -  Nov 9, 2007
ХаноÑ? более трёх килограммов героина и двух килограммов фенобарбитала (phenobarbital), Ñ?ообщает РИÐ? "Ð?овоÑ?ти" Ñ?о Ñ?Ñ?ылкой на меÑ?тное телевидение. ... NEWSru.ua

SEE A VETERINARY NEUROLOGIST  -  Aug 21, 2006
The vet has him on phenobarbital three times daily. ... Is there an alternative to phenobarbital? We love our dog and hate to see him go through this. ... Pay-Per-View - South Florida Sun - Sentinel - ProQuest Archiver

A Biting Pup Is Doing What Comes Naturally  -  Aug 28, 2008
We changed vets a year ago, and she was put on phenobarbital, 4 milligrams ... Phenobarbital at low doses helps control the seizures, as you have found. ... Pay-Per-View - Washington Post - ProQuest Archiver

Dùng thuốc hướng thần cho nữ  -  Nov 12, 2007
Phenobarbital: Ức chế hệ thần kinh trung ương, có tác dụng rất mạnh với tế bào thần ... Phenobarbital thấm qua nhau thai nên ngư�i có thai bị động kinh dùng ... Tin nhanh

У Литві корвалол Ñ– валокордин оголоÑ?или наркотиками  -  Aug 31, 2005
що в 3-й Ñ?пиÑ?ок наркотичних Ñ– пÑ?ихотропних препаратів, затверджених наказом мініÑ?терÑ?тва охорони здоров'Ñ? Литви, включено фенобарбітал (phenobarbital). ... KореÑ?пондент

Mild hypothermia via selective head cooling as neuroprotective...  -  Jan 12, 2006
An additional 5–10 mg/kg of phenobarbital was administered if clinical seizures continued and the phenobarbital levels were subtherapeutic. ... Nature.com

Neonatal withdrawal syndrome following in utero exposure to paroxetine...  -  Jan 19, 2007
An electroencephalogram showed background suppression, secondary to phenobarbital. No evidence of underlying epileptic activity was noted. ... Nature.com

The effect of cytochrome P450 metabolism on drug response, interaction...  -  Aug 1, 2007
...(7,8) One in five Asian persons is a poor metabolizer of drugs dependent on CYP2C19, which metabolizes phenytoin (Dilantin), phenobarbital, ... Free with registration - American Family Physician - AccessMyLibrary.com

Todd's Story  -  Jul 3, 2006
Three days after Sanders first reduced Todd's dosage of phenobarbital, ... His dosage of phenobarbital was not increased, according to his written treatment ... Enterprise-Record

ЗаÑ?Ñ?коха фалшив Sedalgin Neo в аптечната мрежа  -  Dec 30, 2005
Поради Ñ?ъдържанието на Phenobarbital, производно на барбитуровата киÑ?елина, ... ЛекарÑ?твеното вещеÑ?тво Phenobarbital е клаÑ?ифицирано в групата на риÑ?ковите ... Econ.bg

Loislaw Federal District Court Opinions - CONNOLLY v. FIRST …  -  Nov 18, 2008
The test indeed showed a positive result for Phenobarbital. ... At the time of the drug test, Connolly did in fact have Phenobarbital in her system because ... Pay-Per-View - Loislaw Federal District Court Opinions - Loislaw

Epileptic seizures in dogs  -  May 17, 2005
The two most widely used antiepileptic drugs are potassium bromide and phenobarbital. Potassium bromide may not be as effective at stopping seizures as ... ESPN

Local Regional Evidence seized in suspect vet's office .  -  Apr 19, 2005
Police seized four bottles of phenobarbital tablets and the drugs and Euthasol, which contain pentobarbital, in Wendi Davidson's veteri narian offices ... Bangor Daily News - Google News Archive

Millions of Children Denied Drug That Costs Less Than $3 a Year  -  Jun 10, 2007
Regrettably, most of these people, many of whom are children, could return to a normal life by taking a single daily dose of a drug (phenobarbital) that ... MedIndia

New data on antiepileptic drugs.(DRUGS, PREGNANCY, AND …  -  Oct 15, 2006
Phenobarbital has been associated with an increase in congenital defects when ... Two AEDs (primidone and phenobarbital) are known to cause toxicity in the ... $4.95 - Internal Medicine News - ECNext

First-generation anticonvulsants.(Drugs, Pregnacy, And Lactation)( …  -  Sep 1, 2006
Phenobarbital has been associated with an increase in congenital defects when ... Two AEDs (primidone and phenobarbital) are known to cause toxicity in the ... Pay-Per-View - Family Practice News - Factiva, from Dow Jones

Barbiturates (Systemic).  -  Aug 1, 2006
For phenobarbital For (oral) dosage form (elixir, capsules, or tablets): For trouble in sleeping: Adults -- 100 to 320 milligrams (mg) at bedtime. ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Barbiturates (Systemic).(Drug overview)  -  May 1, 2006
For phenobarbital For (oral) dosage form (elixir, capsules, or tablets): For trouble in sleeping: Adults -- 100 to 320 milligrams (mg) at bedtime. ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

NKCC1 transporter facilitates seizures in the developing brain  -  Oct 9, 2005
Intraperitoneal administration of phenobarbital (25 mg/kg) or bumetanide (0.1–0.2 mg/kg) preceding onset of kainate acid–induced seizures depressed power of ... Nature.com

Management of neonatal abstinence syndrome in neonatal intensive care...  -  Nov 24, 2005
In all, 53 respondents (70%) use phenobarbital, and 19 (25%) use intravenous morphine to control opioid withdrawal seizures, while 61 (81%) use ... Nature.com

Transplacental isopropanol exposure: case report and review of …  -  Sep 3, 2006
A urine toxicology screen (sent after the initiation of phenobarbital) was positive ... She was discharged on phenobarbital at 2 weeks of age with a normal ... Nature.com

Drug treatments for epilepsy  -  Dec 4, 2008
Phenobarbital: This is one of the main drugs that doctors use to try to stop seizures. (Phenobarbital is not sold under a brand name in the UK.) More... ... guardian.co.uk

State v. Oliver, 170 P.3d 387, 144 Idaho 722 (Idaho 10/17/2007)  -  Oct 17, 2007
It later tested positive for oxycodone, Phenobarbital (a barbiturate) and ... Phenobarbital is a barbiturate typically used to treat seizure disorders. ... $2.95 - Idaho Supreme Court - VersusLaw

Adverse Effects of Antiepileptic Medications in Children: A Case...  -  Jul 1, 2005
Phenobarbital The CNS side effects of phenobarbital limit its usefulness in children. ... 7 Phenobarbital also may increase the risk of fractures and, ... Psychiatric Times

Epilepsy: Drugs may not be needed  -  Jun 28, 2005
Phenobarbital is a potent narcotic. It works by increasing the brain's ability to withstand a higher level of whatever stimulus or stimuli cause the ... OCRegister

Local Regional Evidence seized in suspect vet's office .  -  Apr 19, 2005
According to the logbooks police photographed during a search in mid- January, was treated with phenobarbital and Valium tablets and liquid Valium, ... Bangor Daily News - Google News Archive

Psychiatric Times. Cognitive Side Effects of Antiepileptic Drugs in …  -  Sep 1, 2005
The effects of phenobarbital are well established since it was used for many ... In studies, children on phenobarbital displayed IQ declines (Farwell et al. ... Psychiatric Times

Carbamazepine Oral: Dosage, Uses and Warnings  -  Oct 4, 2005
MECHANISM OF ACTION: Carbamazepine, phenobarbital, and phenytoin may induce the ... CLINICAL EFFECTS: Concurrent use of carbamazepine, phenobarbital, ... Medscape

Belladonna Alkaloids and Barbiturates (Systemic).  -  Oct 27, 2005
For atropine, hyoscyamine, scopolamine, and phenobarbital combination For stomach or ... Children -- Use is not recommended. For atropine and phenobarbital. Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Impact of prenatal exposure to anticonvulsants appears small.(Across ...  -  Sep 1, 2006
The use of carbamazepine, phenytoin, or phenobarbital as monotherapy by pregnant women was not associated with significant deficits in full-scale IQ in ... Free with registration - Clinical Psychiatry News - AccessMyLibrary.com

Should amplitude-integrated electroencephalography be used to...  -  Nov 15, 2007
Only 1 of the 25 infants with a normal aEEG received phenobarbital before evaluation. Four of the 46 study infants died before MRI evaluation. ... Nature.com

Sterling v. McKesson Automation, Inc., No. 02: 04cv1470 (WDPa. 09/26/...  -  Sep 26, 2006
Since that time, Plaintiff has almost continuously taken phenobarbital and continues to take it daily. At age 26, Plaintiff had a grand mal seizure when he ... $2.95 - U.S. District Court, Western District... - VersusLaw

Burglars take animal pills  -  Nov 1, 2006
Phenobarbital, a barbiturate, is commonly used to control epilepsy or as a sedative to relieve anxiety. Anyone with information is asked to contact Daytona ... Pay-Per-View - Orlando Sentinel - ProQuest Archiver

Breast-feeding may help ease AED withdrawal.(Obstetrics)  -  Mar 1, 2005
And speaking of phenobarbital, some obstetricians still favor it for seizure control in pregnancy, although the practice is no longer recommended. ... Pay-Per-View - OB GYN News - Factiva, from Dow Jones

The effect of cytochrome P450 metabolism on drug response, interaction...  -  Aug 1, 2007
...(7,8) One in five Asian persons is a poor metabolizer of drugs dependent on CYP2C19, which metabolizes phenytoin (Dilantin), phenobarbital, ... $4.95 - American Family Physician - ECNext

Columbia University, US Findings from studies by Columbia University,...  -  Jan 9, 2007
..."Gabapentin was compared with phenobarbital for the treatment of alcohol withdrawal in a randomized, open-label, controlled trial in 27 inpatients. ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

Seizures aren't always just a brain problem  -  Sep 10, 2006
My vet put him on the drug phenobarbital, but it doesn't seem to be working. ... Phenobarbital is the gold standard of medical treatments for epilepsy. ... $2.95 - Herald & Review - NewsBank

Lipid lowering inefficacy of high-dose statin therapy due to concurren...  -  Dec 1, 2006
...(11) Phenytoin, phenobarbital and rifampin induce all of the CYP enzymes and thus carry the potential of lowering the availability of various drugs ... $4.95 - Southern Medical Journal - ECNext

Patience, persistence pay dividends in pet care  -  Aug 6, 2006
Phenobarbital is the gold standard of epilepsy treatments. ... Beth kept administering the phenobarbital, since it often takes a week for the medication to ... $2.95 - Herald & Review - NewsBank

Trial tracks rate of rash in three epilepsy drugs.(News) | Article...  -  Mar 1, 2005
Phenobarbital can cause morbilliform reactions, urticaria ... said. some atypical cutaneous effects are reported with carbamazepine hypersensitivity, ... Pay-Per-View - Skin & Allergy News - HighBeam Research

The Grass Isn't Always Greener for Your Pet  -  May 1, 2008
...including attention to dietary ingredients, routine use of veterinary medications and the judicious use of anti-seizure drugs such as phenobarbital, ... Pay-Per-View - Washington Post - ProQuest Archiver

The Best Pet Food Is Not on the Shelves. It's Made at Home. | Article...  -  Jul 24, 2008
He continued to have monthly seizures, even while on increasing doses of phenobarbital. Then my vet tested him for hypothyroidism, which seems to be the ... Pay-Per-View - Washington Post - HighBeam Research

Vet faked euthanasia, Bucks lawsuit alleges ** Couple accuse clinic...  -  Apr 28, 2006
Annie's diagnosis was idiopathic epilepsy -- seizures for which no cause can be determined -- and she was prescribed phenobarbital by Makem, according to ... Pay-Per-View - Morning Call - ProQuest Archiver

Ocala Star-Banner (FL)  -  Aug 13, 2006
The vet has him on phenobarbital three times daily. ... Is there an alternative to phenobarbital? We love our dog and hate to see him go through this. ... $2.95 - Ocala Star-Banner - NewsBank

Reader angered by mass dog killings  -  Aug 10, 2006
The vet has him on phenobarbital three times daily At the begin ning, ... Is there an alter native to phenobarbital? We love our dog and hate to see him go ... Bangor Daily News - Google News Archive

Women and Epilepsy: Pregnancy Registries Yield Valuable Information  -  Jan 5, 2005
In a retrospective Danish study, men exposed in utero to phenobarbital had a ... In utero exposure to phenobarbital and intelligence deficits in adult men. ... Medscape

Refractory status epilepticus.(Review Article)  -  Oct 1, 2006
High dose phenobarbital High dose of phenobarbital with serum levels of 100 to ... 58] In another study a very high dose phenobarbital at accumulated daily ... Free with registration - Neurology India - AccessMyLibrary.com

Aged Garlic Extract Inhibits Development of Putative Preneoplastic …  -  Mar 12, 2006
Diethylnitrosamme (DEN) and phenobarbital sodium salt were purchased from Tokyo ... A 0.05% phenobarbital-containing diet was prepared by Clea Japan, ... RedOrbit

Clinical management of a patient with a 12-year history of a balance ...  -  Aug 1, 2007
His medical history also included epilepsy, for which he was taking phenytoin and phenobarbital, and prostate cancer. His family history was not ... Free with registration - Ear, Nose and Throat Journal - AccessMyLibrary.com

Wrong diet is what's bugging bunny  -  Jan 2, 2007
My vet was quick to diagnose epilepsy and put Taj on phenobarbital. I tried to speak with the vet about other possibilities, such as brain infections, ... Arizona Daily Star

Donnatal.(Drug overview)  -  Jan 22, 2007
One of its ingredients, phenobarbital, is a mild sedative. Phenobarbital, one of the ingredients of Donnatal, can be habit-forming. ... Free with registration - PDR Family Guide to Prescription Drugs - AccessMyLibrary.com

Older epilepsy drugs increase birth defect risk  -  Jan 11, 2005
Pregnant women with epilepsy who take either of two older medications to control their seizures -- sodium valproate or phenobarbital -- are at increased ... macleans.ca

Brand Names/Synonyms:
Phenobarbital is also known by the following brand names and/or synonymsAdonal; Aephenal; Agrypnal; Amylofene; Aphenylbarbit; Aphenyletten; Barbenyl; Barbinal; Barbiphen; Barbiphenyl; Barbipil; Barbita; Barbivis; Barbonal; Barbophen; Bardorm; Bartol; Bialminal; Blu-Phen; Cabronal; Calmetten; Calminal; Cardenal; Chinoin; Codibarbita; Coronaletta; Cratecil; Damoral; Dezibarbitur; Dormina; Dormiral; Dormital; Doscalun; Duneryl; Ensobarb; Ensodorm; Epanal; Epidorm; Epilol; Episedal; Epsylone; Eskabarb; Etilfen; Euneryl; Fenbital; Fenemal; Fenobarbital; Fenosed; Fenylettae; Gardenal; Gardepanyl; Glysoletten; Haplopan; Haplos; Helional; Hennoletten; Henotal; Hypnaletten; Hypnette; Hypno-Tablinetten; Hypnogen; Hypnolone; Hypnoltol; Hysteps; Lefebar; Leonal; Lephebar; Lepinal; Lepinaletten; Linasen; Liquital; Lixophen; Lubergal; Lubrokal; Lumen; Lumesettes; Lumesyn; Luminal; Lumofridetten; Luphenil; Luramin; Molinal; Neurobarb; Nirvonal; Noptil; Nova-Pheno; Nunol; Parkotal; Pharmetten; Phen-Bar; Phenaemal; Phenemal; Phenemalum; Phenobal; Phenobarbital; Phenobarbitol; Phenobarbitone; Phenobarbituric Acid; Phenobarbyl; Phenoluric; Phenolurio; Phenomet; Phenonyl; Phenoturic; Phenylethylbarbiturate; Phenylethylbarbituric Acid; Phenylethylmalonylurea; Phenyletten; Phenyral; Phob; Polcominal; Promptonal; Seda-Tablinen; Sedabar; Sedicat; Sedizorin; Sedlyn; Sedofen; Sedonal; Sedonettes; Sevenal; Sinoratox; Sk-Phenobarbital; Solfoton; Solfoton Talpheno; Solu-Barb; Sombutol; Somnolens; Somnoletten; Somnosan; Somonal; Spasepilin; Starifen; Starilettae; Stental; Stental Extentabs; Talpheno; Teolaxin; Teoloxin; Thenobarbital; Theoloxin; Triabarb; Tridezibarbitur; Triphenatol; Versomnal; Zadoletten; Zadonal

Drug Category:
Phenobarbital is categorized under the following by the FDA: Hypnotics and Sedatives; Anticonvulsants;

Dosage Forms:
Tablets and Elixir

Absorption:
absorbed in varying degrees following oral, rectal or parenteral administration. The salts are more rapidly absorbed than are the acids. The rate of absorption is increased if the sodium salt is ingested as a dilute solution or taken on an empty stomach

Interactions:
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Chemical IUPAC Name:
5-ethyl-5-phenyl-hexahydropyrimidine-2,4,6-trione





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