Pilocarpine

This page contains recent news articles, when available, and an overview of Pilocarpine but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Pilocarpine
(when available)

Pharmacology and use:
Pilocarpine is a choline ester miotic and a positively charged quaternary ammonium compound. Pilocarpine, in appropriate dosage, can increase secretion by the exocrine glands. The sweat, salivary, lacrimal, gastric, pancreatic, and intestinal glands and the mucous cells of the respiratory tract may be stimulated. When applied topically to the eye as a single dose it causes miosis, spasm of accommodation, and may cause a transitory rise in intraocular pressure followed by a more persistent fall. Dose-related smooth muscle stimulation of the intestinal tract may cause increased tone, increased motility, spasm, and tenesmus. Bronchial smooth muscle tone may increase. The tone and motility of urinary tract, gallbladder, and biliary duct smooth muscle may be enhanced. Pilocarpine may have paradoxical effects on the cardiovascular system. The expected effect of a muscarinic agonist is vasodepression, but administration of pilocarpine may produce hypertension after a brief episode of hypotension. Bradycardia and tachycardia have both been reported with use of pilocarpine. For the treatment of radiation-induced dry mouth (xerostomia) and symptoms of dry mouth in patients with Sjögrens syndrome

Mechanism Of Action:
Pilocarpine is a cholinergic parasympathomimetic agent. It increase secretion by the exocrine glands, and produces contraction of the iris sphincter muscle and ciliary muscle (when given topically to the eyes) by mainly stimulating muscarinic receptors.

News Articles on Pilocarpine

Chemokine CCL2 and its receptor CCR2 are increased in the hippocampus ...  -  ‎Dec 25, 2009‎
In this work CCR2 and CCL2 expression were examined following status epilepticus induced by pilocarpine injection. Methods: Status epilepticus (SE) was ... 7thSpace Interactive (press release)

Sjogren's Syndrome Update  -  ‎Dec 31, 2009‎
Other drugs being tested are rituximab, mycophenolate, hydroxychloroquine, rebamipide, pilocarpine, anakinra, dexamethasone, azathioprine, and thalidomide ... EmpowHer (blog)

Local expression of tumor necrosis factor-receptor 1:immunoglobulin G can ...  -  ‎Dec 15, 2009‎
Pilocarpine stimulated saliva flow was measured to address the SG function and SGs were analyzed for focus score and cytokine profiles. ... 7thSpace Interactive (press release)

Status epilepticus affects the gigantocellular network of the pontine ...  -  ‎Nov 13, 2009‎
...by the sensitive silver method of Gallyas in rats sacrificed at 3 h after focal 4-AP crystal or systemic 4-AP, pilocarpine, or kainic acid application. ... 7thSpace Interactive (press release)

Extending a nurse practitioner's role to undertake advanced procedures  -  ‎Oct 19, 2009‎
One drop of apraclonidine 1% and one drop of pilocarpine 2% were instilled into the eye approximately 15 minutes before laser treatment. ... Nursing Times

Neurostéroïdes et épilepsie  -  ‎Oct 27, 2009‎
Neurosteroids and epileptogenesis in the pilocarpine model: evidence for a relationship between P450scc induction and length of the latent period. ... Épilepsies

A controlled release pilocarpine buccal insert in the treatment of...  -  Feb 2, 2007
This study evaluated the use of a hydrogel polymer buccal insert as a controlled release delivery vehicle for pilocarpine. The insert delivered in excess of ... Nature.com

Effect of pilocarpine hydrochloride on unstimulated whole saliva flow...  -  Feb 19, 2007
Correspondence: Dr F Agha-Hosseini, Department of Oral Medicine, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran. ... Nature.com

… traction associated with the use of pilocarpine to reverse...  -  Oct 19, 2007
We present a case of vitreofoveal traction induced by one drop of pilocarpine given for reversal of mydriasis. A 64-year-old white female was dilated for a ... Nature.com

Link between asthma and sweating  -  Sep 9, 2008
The rate of pilocarpine-stimulated sweat secretion in the healthy volunteers also correlated highly with salivary flow rate and tearing rate. ... Scotsman

Lannett Company Receives Approval for Pilocarpine HCL  -  Oct 17, 2005
Lannett Company, Inc. (AMEX:LCI), a manufacturer of generic pharmaceuticals, today announced that it has received approval from the US Food and Drug ... RedOrbit

Learn about Pilocarpine from Consumer Reports Health.  -  Jan 7, 2008
Pilocarpine is used to treat dry mouth caused by radiotherapy in people with head and neck cancer and to treat dry mouth in people with Sjogren's syndrome ... consumerreports.org

Marillion Pharmaceuticals licensing Cytokine dry mouth treatment  -  Feb 25, 2008
Marillion CEO Zahed Subhan said Pilobuc would be an alternative to pilocarpine tablets for dry mouth, and that it was "shown in clinical trials to ... Bizjournals.com

… launches pilocarpine 7.5mg in USA.(launch of pilocarpine tablets...  -  Sep 11, 2006
Through its US manufacturing and marketing division, Icelandic generic pharmaceutical company Actavis Group has begun shipping pilocarpine HCl 7.5mg tablets ... Free with registration - Pharma Marketletter - AccessMyLibrary.com

Press Release: Actavis Launches Pilocarpine Tablets 7.5mg in the US -...  -  Sep 6, 2006
Actavis Launches Pilocarpine Tablets 7.5mg in the US from PR Newswire. Highbeam Research – FREE Trial. Pay-Per-View - PR Newswire - HighBeam Research

Actavis Launches Pilocarpine Tablets 7.5mg in the US  -  Sep 6, 2006
CRANFORD, NJ, Sept. 6 /PRNewswire/ -- . Actavis US, the United States manufacturing and marketing division of the international generic pharmaceutical ... $4.95 - PR Newswire - ECNext

… of 131I-Induced Sialadenitis: The Role of Pilocarpine -- Silberstei...  -  Mar 14, 2008
Conclusion: Under the conditions of the study, pilocarpine did not reduce the occurrence of radiation sialadenitis or stomatitis. The occurrence, however ... Journal of Nuclear Medicine (subscriptio...

Illinois Administrative Code - 77 Ill. Adm. Code 790.7245 PILOCARPINE...  -  Aug 10, 2005
77 Ill. Adm. Code 790.7245 PILOCARPINE HYDROCHLORIDE (Repealed) Repealed. (Source: Repealed at 17 Ill. Reg. 15916, effective September 20, 1993) ... Pay-Per-View - Illinois Administrative Code - Loislaw

Pilocarpine hydrochloride.  -  Oct 23, 2006
Pilocarpine hydrochloride. Iceland-based Actavis, with U.S. headquarters in Cranford, N.J., (800) 432-8534, has begun shipping pilocarpine hydrochloride ... $9.94 - Drug Topics - Alacra Store

Cutaneous Microdialysis as a Novel Means of Continuously Stimulating ...  -  Sep 10, 2005
Muscarinic stimulation with pilocarpine nitrate (50 g ml -1 to 1.66 mg ml -1 ... Pilocarpine administered via the probe caused a concentration-dependent ... Nature.com

pilocarpine | Definition of pilocarpine | HighBeam.com: Online...  -  Jul 12, 2006
Find out what pilocarpine means: The Oxford American College Dictionary has the definition of pilocarpine. Research related newspaper, magazine, ... Pay-Per-View - Oxford American College Dictionary - HighBeam Research

Sweating A Defense Against Exercise Induced Asthma  -  Sep 13, 2008
After that another chemical pilocarpine was given to induce sweating. It was found that the volunteers, who tended to sweat the most after the ... Visit Bulgaria

A controlled release buccal insert  -  Apr 14, 2007
The insert delivered in excess of 85% of a 5 mg dose of pilocarpine hydrochloride with minimal side-effects; oral and eye comfort scores generally improved ... Nature.com

Pennsylvania Code of Regulations - 28 Pa. Code § 25.58B. Generically ...  -  Jul 16, 2005
Labs Steris Labs PHYSOSTIGMINE SALICYLATE/PILOCARPINE HCL Ophthalmic Solution ... Pharmafair Pilocarpine HCl Henry Schein Pharmafair Pilocarpine HCl H L ... Pay-Per-View - Pennsylvania Code of Regulations - Loislaw

Accuracy of GDx variable corneal compensation polarization …  -  Dec 9, 2005
Pilocarpine induced miosis did not alter VCC retardation or its axis when compared to ... In this study, we assessed the effect of pilocarpine-induced ... Nature.com

Figure 2 : A role for leukocyte-endothelial adhesion mechanisms in …  -  Nov 23, 2008
...(a–c) Quantification of the mean number of daily spontaneous convulsions (SC) per mouse, as determined by visual monitoring from days 5–20 after pilocarpine ... Nature.com

Acute angle-closure glaucoma -management (acute-pupil block …  -  Jan 20, 2006
Pilocarpine 2 per cent may also be used. One drop should be instilled every 15 ... Pilocarpine should also be instilled in the other eye to prevent the ... Optician Online

BAB.COM باب - الموقع العربي العملاق: الجريدة، النوادي، الخدمات، ا?  -  Jul 16, 2008
استخدام عقار الـ (بيلوكاربين – Pilocarpine) داخل (مستشÙ?ÙŠ جمال عبد الناصر) بالإسكندرية . ... باب

The clinical validity of the treatment satisfaction survey for...  -  Jun 3, 2005
Laibovitz noted that pilocarpine was significantly more associated with vision ... Compliance with topical pilocarpine treatment. Am J Ophthalmol 1986; ... Nature.com

Benign episodic unilateral mydriasis  -  May 12, 2006
It was observed that 0.125% Pilocarpine did not constrict the pupil, whereas 1% Pilocarpine constricted both pupils well. The anisocoria spontaneously ... Nature.com

Drug Development; Generic Salagen 5mg tablets launched  -  Apr 4, 2005
Pilocarpine tablets are indicated for the treatment of dry mouth caused ... Alpharma and MGI Pharma will share profits on sales of pilocarpine 5mg tablets. ... Pay-Per-View - Pharma Business Week - Factiva, from Dow Jones

Link between asthma and sweating  -  Sep 8, 2008
The rate of pilocarpine-stimulated sweat secretion in the healthy volunteers also correlated highly with salivary flow rate and tearing rate. ... NHS Choices

Medical versus surgical interventions for open angle glaucoma  -  Jul 1, 2007
In three trials, primary medication was usually pilocarpine, in one trial a beta – blocker. In the most recent trial, participants with mild OAG, ... Medscape

Alpharma Launches Authorized Generic of MGI PHARMA's Salagen(R) …  -  Feb 22, 2005
Pilocarpine tablets are indicated for the treatment of dry mouth caused ... Alpharma and MGI PHARMA will share profits on sales of pilocarpine 5mg tablets. ... $4.95 - PR Newswire - ECNext

Article: Generics makers keep product pipeline moving.(RX/GENERIC …  -  Sep 25, 2006
Actavis U.S. has begun shipping pilocarpine hydrochloride 7.5-mg tablets to ... Pilocarpine is used to treat dryness of the mouth and throat caused by a ... Pay-Per-View - Chain Drug Review - HighBeam Research

Press Release: Alpharma Launches Authorized Generic of MGI …  -  Feb 22, 2005
Pilocarpine tablets are indicated for the treatment of dry mouth caused ... Alpharma and MGI PHARMA will share profits on sales of pilocarpine 5mg tablets. ... Pay-Per-View - PR Newswire - HighBeam Research

Generics makers keep product pipeline moving.  -  Sep 25, 2006
Actavis U.S. has begun shipping pilocarpine hydrochloride 7.5-mg tablets to ... Pilocarpine is used to treat dryness of the mouth and throat caused by a ... $20.00 - Chain Drug Review - Alacra Store

Neuroscience; Status epilepticus modeled, modulation of CaM kinase II...  -  Oct 28, 2005
The pilocarpine model of SE was characterized both behaviorally and electrographically. At specific time points after the first discrete seizure, ... Pay-Per-View - Drug Week - Factiva, from Dow Jones

Al-Ahram Weekly | Egypt | Newsreel  -  Mar 8, 2007
The hospital's report said Pilocarpine ampoules are usually imported from the US. Those contaminated were imported from India. They were made of plastic, ... Al-Ahram Weekly

Comparison of ultrasound biomicroscopic parameters after laser …  -  May 5, 2006
Pilocarpine was stopped atleast 1 week before UBM measurements and patients were put on oral acetazlamide (250 mg TDS) and 0.5% timolol eye drops. ... Nature.com

Neuroscience; Status epilepticus modeled, modulation of CaM kinase II...  -  Oct 24, 2005
The pilocarpine model of SE was characterized both behaviorally and electrographically. At specific time points after the first discrete seizure, ... Pay-Per-View - Health & Medicine Week - Factiva, from Dow Jones

dry mouth, thirst, excessive thirst, saliva deficiency, xerostomia,Sjö...  -  Apr 7, 2008
Intractable xerostomia may be treatable with medication such as pilocarpine. Pilocarpine improves the output of salivary and lacrimal (tear producing) ... DentalPlans.com

Virginia Commonwealth University; Status epilepticus modeled, …  -  Oct 26, 2005
The pilocarpine model of SE was characterized both behaviorally and electrographically. At specific time points after the first discrete seizure, ... Pay-Per-View - Biotech Week - Factiva, from Dow Jones

FDA first-time generics approvals--2006.(Special Report)(Statistical...  -  Feb 19, 2007
Chain Drug Review; September 25, 2006 ; 700+ words ... ... pilocarpine hydrochloride ... Salagen--complements the 5-mg pilocarpine hydrochloride tablets . ... Pay-Per-View - Chain Drug Review - HighBeam Research

Multimodal mechanisms of lens may account for near vision performance:...  -  Jun 15, 2006
Using pilocarpine and cyclopentolate for pharmacologic stimulation and paralysis of accommodation, he determined that the accommodating IOL moved anteriorly ... Free with registration - Ophthalmology Times - AccessMyLibrary.com

Acute angle closure glaucoma.(Signs and Symptoms)(Disease/Disorder …  -  Mar 15, 2006
Once the IOP is below 40 mm Hg, topical pilocarpine 2% can be used to abate ... Higher concentrations of pilocarpine should be avoided as they can lead to ... Free with registration - Review of Optometry - AccessMyLibrary.com

Figure 4 : A role for leukocyte-endothelial adhesion mechanisms in …  -  Nov 23, 2008
...inferior and lateral brain views and sagital brain sections are shown to document Evans blue extravasation at 18–24 h after pilocarpine injection. ... Nature.com

First-Time Generic Approvals: Glucotrol XL, Retrovir, Salagen  -  Apr 7, 2006
Pilocarpine tablets are indicated for the treatment of dry mouth resulting from salivary gland hypofunction caused by radiotherapy for cancer of the head ... Medscape

Persistent traumatic mydriasis alleviated with cerclage pupilloplasty....  -  Dec 15, 2005
Efforts to reduce pupillary diameter with 2% pilocarpine applied topically had failed and the patient was unable to manage a colored contact lens ... Free with registration - Ophthalmology Times - AccessMyLibrary.com

Beta-blockers for glaucoma  -  May 23, 2008
Beta-blockers may be more effective than pilocarpine or epinephrine alone. Stinging, aching, or redness in the eyes after using drops. ... WebMD

Jaborandi.(Drug overview)  -  Jun 1, 2006
The drug is used today as an industrial agent for the manufacture of pilocarpine, but is used medicinally only for homeopathic applications. ... Free with registration - PDR for Herbal Medicines - AccessMyLibrary.com

Alpharma debuts authorized generic Salagen.(Brief Article)  -  Feb 28, 2005
Pilocarpine tablets are indicated for the treatment of dry mouth caused by ... The two companies will share profits on sales of generic pilocarpine. Free with registration - Pharma Marketletter - AccessMyLibrary.com

Neurological disease: Unsticking for seizure prevention  -  Dec 1, 2008
The authors show that pilocarpine-induced acute seizure activity in mice increases the expression of leukocyte adhesion molecules — such as mucin P-selectin ... Nature.com

Glaucoma In-Depth Report  -  Sep 13, 2006
Miotics, which include pilocarpine and others, were the standard drugs before the ... Because pilocarpine is used up by the body fairly quickly, however, ... New York Times

Coated microneedles successfully deliver drugs to eyes in vitro  -  Sep 25, 2007
Similarly, microneedle delivery of pilocarpine caused rapid and extensive rabbit pupil constriction, the authors found. Microneedle insertion caused no ... OSN SuperSite

Marginal keratitis.(CORNEA)(Disease/Disorder overview)  -  Mar 15, 2007
Erosive marginal keratitis due to pilocarpine allergy. Oftalmologia 1999;47(2):83-4. 11. Taguri AH, Khan MA, Sanders R. Marginal keratitis: an uncommon form ... Free with registration - Review of Optometry - AccessMyLibrary.com

Epilepsy; Physical training reverts hippocampal electrophysiological ...  -  Jan 11, 2005
..."Our results indicate that physical training reduces CA1 hyperresponsiveness and can modify synaptic plasticity in rats submitted to the pilocarpine model ... Pay-Per-View - Science Letter - Factiva, from Dow Jones

MEDICINE CABINET: Options for treating inflamed salivary glands  -  Dec 2, 2008
..._ Medications, such as pilocarpine (Salagen), to increase salivary flow for Sjogren's syndrome. In general, it makes sense to see an otolaryngologist (ear, ... Pay-Per-View - Newsday - ProQuest Archiver

Louis Pasteur University; Influence of PAMAM dendrimer features on …  -  Apr 20, 2005
Keywords: Illkirch Graffenstaden, France, Pilocarpine Nitrate, Tropicamide, Biotechnology, Drug Delivery, Medical Devices, Ophthalmology and Pharmaceutical ... Pay-Per-View - Biotech Week - Factiva, from Dow Jones

Drug Delivery; Influence of PAMAM dendrimer features on ocular drug …  -  Apr 24, 2005
Keywords: Illkirch Graffenstaden, France, Pilocarpine Nitrate, Tropicamide, Biotechnology, Drug Delivery, Medical Devices, Ophthalmology and Pharmaceutical ... Pay-Per-View - Medical Devices & Surgical Technology... - Factiva, from Dow Jones

Epilepsy; Physical training reverts hippocampal electrophysiological ...  -  Jan 14, 2005
..."Our results indicate that physical training reduces CA1 hyperresponsiveness and can modify synaptic plasticity in rats submitted to the pilocarpine model ... Pay-Per-View - Drug Week - Factiva, from Dow Jones

Neural Stem Cells; Neural stem cell transplantation reduces spontaneou...  -  Jan 4, 2005
..."Experimental status epilepticus was induced by lithium-pilocarpine injection, and beta galactosidase-encoded human NSCs were transplanted intravenously on ... Pay-Per-View - Science Letter - Factiva, from Dow Jones

Neural Stem Cells; Neural stem cell transplantation reduces spontaneou...  -  Jan 8, 2005
..."Experimental status epilepticus was induced by lithium-pilocarpine injection, and beta galactosidase-encoded human NSCs were transplanted intravenously on ... Pay-Per-View - Obesity, Fitness & Wellness Week - Factiva, from Dow Jones

Neural Stem Cells; Neural stem cell transplantation reduces spontaneou...  -  Jan 3, 2005
..."Experimental status epilepticus was induced by lithium-pilocarpine injection, and beta galactosidase-encoded human NSCs were transplanted intravenously on ... Pay-Per-View - Hematology Week - Factiva, from Dow Jones

Roxane Laboratories.  -  May 2, 2005
Roxane Laboratories also announced the launch of pilocarpine HCl tablets in 5 mg ... Pilocarpine HCl tablets are the AB-rated equivalent of MGI Pharma's ... $9.94 - Drug Store News - Alacra Store

Drug Delivery; Influence of PAMAM dendrimer features on ocular drug …  -  Apr 18, 2005
Keywords: Illkirch Graffenstaden, France, Pilocarpine Nitrate, Tropicamide, Biotechnology, Drug Delivery, Medical Devices, Ophthalmology and Pharmaceutical ... Pay-Per-View - Health & Medicine Week - Factiva, from Dow Jones

Neural Stem Cells; Neural stem cell transplantation reduces spontaneou...  -  Jan 3, 2005
..."Experimental status epilepticus was induced by lithium-pilocarpine injection, and beta galactosidase-encoded human NSCs were transplanted intravenously on ... Pay-Per-View - Pain & Central Nervous System Week - Factiva, from Dow Jones

Ciliary body thickness in unilateral high axial myopia  -  Apr 27, 2007
Age-related loss of morphologic responses to pilocarpine in rhesus monkey ciliary muscle. Arch Ophthalmol 1988; 106: 1591–1598. | PubMed | ChemPort | ... Nature.com

Controlled Therapeutics licence agreement announced  -  Mar 20, 2008
Pilobuc is a novel, proprietary, buccal formulation of pilocarpine shown in clinical trials to effectively and conveniently deliver the drug with reduced ... Scottish Enterprise

Twenty-four-hour efficacy of the brimonidine/timolol fixed combination...  -  Jun 15, 2007
24 hour intraocular pressure reduction with latanoprost compared with pilocarpine as third-line therapy in exfoliation glaucoma. Eye 2001; 15: 59–62. ... Nature.com

БиотехнологиÑ? : Создание функционирующей ткани Ñ?люнной желез  -  Feb 26, 2005
Determination of the efficacy of topical oral pilocarpine for ... A phase III placebocontrolled trial of oral pilocarpine in patients undergoing ... КоммерчеÑ?каÑ? биотехнологиÑ?

Common ocular emergencies Part 2 (C-8146)  -  Jan 4, 2008
Pilocarpine can be used to reverse pupil block. ... There is a risk that pilocarpine can raise IOP as ciliary muscle contraction leads to a shallower ... Optician Online

CET round-up.(Company Profile)  -  Dec 9, 2005
This list includes atropine and pilocarpine together with two more antihistamines, the NSAID diclofenac and the combination antibiotic polyfax. ... Free with registration - Optician - AccessMyLibrary.com

New generics.(drug approvals, product introduction)(Brief Article)  -  Mar 21, 2005
Two companies are introducing pilocarpine tablets in 5-mg strength. ... Pilocarpine tablets are available from Alpharma Inc., Fort Lee, NJ, (201) 947-7774 ... Free with registration - Drug Topics - AccessMyLibrary.com

Contact wearers benefit from expanding dry eye therapy: management …  -  May 15, 2005
Oral secretogogue therapy using the cholinergic agonists pilocarpine (Salagen, MGI PHARMA Inc.) or cevimeline (Evoxac, Daiichi Pharmaceuticals) to increase ... Free with registration - Ophthalmology Times - AccessMyLibrary.com

Actavis Group.(RX/GENERIC DRUGS--Profiles)  -  Sep 25, 2006
Among its most recent launches is pilocarpine hydrochloride 7.5-mg tablets. The drug--the generic equivalent of MGI Pharma Inc.'s Salagen--complements the ... Free with registration - Chain Drug Review - AccessMyLibrary.com

John Libbey Eurotext : Éditions médicales et scientifiques France :...  -  Sep 22, 2007
Le test de la sueur consiste à doser l'ion Cl - , directement ou indirectement, dans la sueur recueillie après stimulation par iontophorèse à la pilocarpine ... john-libbey-eurotext.fr

Seizures; Neuropeptide-Y susceptibility in chemical-induced seizure …  -  Jan 17, 2005
..."In addition, susceptibility to pilocarpine- and kainate-induced seizures was compared in NPY(+/+)and(-/-) mice. The rate of amygdala kindling development ... Pay-Per-View - Proteomics Weekly - Factiva, from Dow Jones

Needles may not be the future of immunotherapy.(Clinical Rounds) | …  -  Jun 1, 2005
SAN ANTONIO -- Pilocarpine has potential as a nonestrogenic treatment for the vaginal ... breast cancer survivors, Dr. Charles L. Loprinzi said at the ... Pay-Per-View - Skin & Allergy News - HighBeam Research

Lifestyle modifications can reduce dental decay in Sjogren's.( …  -  Apr 1, 2005
Two prescription salivary substitute medications--pilocarpine (Salagen) and ... Internal Medicine News; April 1, 2008 ; 700+ words ... ... pilocarpine for ... Pay-Per-View - Internal Medicine News - HighBeam Research

Breast ca-related symptoms are hard to treat: vaginal dryness,...  -  Apr 1, 2008
Pilocarpine (Salagen) shows enough promise in improving vaginal dryness that Dr. Loprinzi and colleagues have embarked on an ongoing randomized, ... Pay-Per-View - Internal Medicine News - HighBeam Research

Cystic fibrosis in adults: An update on diagnosis and treatment --...  -  Jan 1, 2006
The workup begins with the quantitative pilocarpine iontophoresis sweat test. ... The general recommendation is to start with the quantitative pilocarpine ... $4.95 - Journal of Respiratory Diseases - ECNext

Eli Lilly & Co. Neuropeptide-Y susceptibility in chemical-induced...  -  Jan 19, 2005
..."In addition, susceptibility to pilocarpine- and kainate-induced seizures was compared in NPY(+/+)and(-/-) mice. The rate of amygdala kindling development ... Pay-Per-View - Biotech Week - Factiva, from Dow Jones

Wisconsin Administrative Code - RL 10.01 Definitions.  -  Jul 16, 2005
Pilocarpine .125%. (f) Any drug which is used for an ophthalmic diagnostic purpose and which is ... Pilocarpine. 3. Miotics, cholinesterase inhibitors. a. ... Pay-Per-View - Wisconsin Administrative Code - Loislaw

Press Release: European Approval for Roche's New Invirase 500 mg …  -  May 27, 2005
Cancer Weekly; April 13, 2004 ; 540 words ... ... and marketing of the Salagen 7.5 mg tablet (pilocarpine hydrochloride) in the . ... Pay-Per-View - PR Newswire Europe - HighBeam Research

Florida Administrative Code - 64B13-18.002 Formulary of Topical...  -  Jul 5, 2005
Pilocarpine HCI — 0.5%, 1.0%, 2.0%, 4.0%; and 3. Pilocarpine gel — 4.0%. (c) Prostaglandins 1. Latanoprost — 0.005%; 2. Bimatoprost — 0.03%; and 3. ... Pay-Per-View - Florida Administrative Code - Loislaw

Company Profile Report  -  Jan 26, 2008
Products:. Salagen (Pilocarpine Hydrochloride). Phase I/Phase II Clinical Stage Products ... Salagen (Pilocarpine Hydrochloride). Hematology ... $50.00 - Revere Reports - Revere

Hives and intense emotions.(Allergies and Side Effects of Medications)...  -  May 1, 2006
At the height of her troubled state, repeat exposure to stroking, pilocarpine, and histamine caused a vigorous urticarial hive reaction. ... Pay-Per-View - Townsend Letter: The Examiner of... - HighBeam Research

Actavis Group.(RX/GENERIC DRUGS--Profiles) | Article from Chain Drug ...  -  Sep 25, 2006
Among its most recent launches is pilocarpine hydrochloride 7.5-mg tablets. The drug--the generic equivalent of MGI Pharma Inc.'s Salagen--complements the ... Pay-Per-View - Chain Drug Review - HighBeam Research

Loislaw Federal District Court Opinions - NEAL v. BOLTON (NDFla. 12-9...  -  Dec 9, 2008
55, 67) is DENIED as to Plaintiff's claims that Dr. Hart unreasonably delayed the provision of eye drops (Pilocarpine Page 2 drops) for Plaintiff's right ... Pay-Per-View - Loislaw Federal District Court Opinions - Loislaw

Article: Drug promising for vaginal dryness after breast cancer.(Acros...  -  Mar 1, 2008
SAN ANTONIO -- Pilocarpine has potential as a nonestrogenic treatment for the vaginal dryness that is a commo... Pay-Per-View - Skin & Allergy News - HighBeam Research

Lannett Co Inc intends a stock buyback - Deal Snapshot - AlacraStore....  -  Jan 27, 2005
M Probenecid Hyperuricemia M Baclofen LANNETT Spasm M Doxycycline monohydrate LANNETT Bacterial Infections M Pilocarpine hydrochloride… ... Pay-Per-View - deals - Alacra Store

Pennsylvania Code of Regulations - 28 Pa. Code § 6.1. Approved drugs.  -  Jul 16, 2005
...(A) Pilocarpine nitrate and pilocarpine hydrochloride — diagnostic use only. (B) Physostigmine. (C) DFP (diisopropylfluorophosphate). (D) Echothiopate. ... Pay-Per-View - Pennsylvania Code of Regulations - Loislaw

Vermont Administrative Rules - NATUROPATHIC PHYSICIAN …  -  Aug 5, 2005
...forms muscle/severe atony drops (tincture) of bladder physo Pilocarpine diaphoretic fevers pilocarpine PO 4-7 days none in nonopthalmic acute skin rxn's ... Pay-Per-View - Vermont Administrative Rules - Loislaw

RS-86, donepezil, muscarinic, acetylcholine, REM, sleep  -  Apr 26, 2005
Pilocarpine, an orally active muscarinic cholinergic agonist, induces REM sleep and reduces delta sleep in normal volunteers. Psychiatry Res 33: 113–119. ... Nature.com

GM, UAW Agree to Health Care Cuts  -  Oct 17, 2005
Lannett (LCI ) received approval from the Food and Drug Administration of its Abbreviated New Drug Application for Pilocarpine HCl tablets for the treatment ... BusinessWeek

Glaucoom (verhoogde oogboldruk)  -  Nov 15, 2005
Pilocarpine zorgt voor pupilvernauwing en bevordert de afvoer van vocht uit het oog. ... Pilocarpine wordt ook in combinatie met andere werkzame stoffen ... kiesbeter.nl

Lewis Gibson, Cystic Fibrosis Expert, Dies at 80  -  Apr 30, 2008
With another researcher, Dr. Robert E. Cooke, Dr. Gibson stimulated sweating by swabbing a small area of skin with an alkaloid called pilocarpine, ... New York Times

Anterior capsule cover and axial movement of intraocular lens  -  May 4, 2007
OS was calculated as difference in anterior chamber depth after administration of cyclopentolate 1% and pilocarpine 2% on IOLMaster ® at separate visits at ... Nature.com

Declaration of competing financial interests  -  Feb 2, 2007
Given the involvement of three employees of Controlled Therapeutics (Scotland) Ltd (JAH, KE and SR) in the development of the overall pilocarpine buccal ... Nature.com

RESOURCES  -  Feb 20, 2005
For serious saliva shortage, take medications that stimulate the salivary glands, such as pilocarpine (Salagen) or cevimeline (Evoxac). ... Pay-Per-View - Chicago Tribune - ProQuest Archiver

No tears to shed: The dry eye disease  -  May 8, 2007
For dryness she was prescribed Pilocarpine, an eye-drop normally given to those with glaucoma, but she takes it orally as tablets and it stimulates the ... Daily Mail

ASK AN EXPERT  -  Jul 17, 2008
Examples include pilocarpine (Isopto Carpine, Pilopine) and carbachol (Isopto Carbachol). Possible side effects are pain around or inside the eyes, ... CNN International

Harlequin syndrome - one face of many etiologies  -  Jun 13, 2005
2 Reaction to administration of 0.125% pilocarpine was normal, excluding the possibility of a parasympathetic lesion. Duplex ultrasonography demonstrated an ... Nature.com

Glaucoma and vision 2020  -  Oct 15, 2008
Mitotics like pilocarpine which have side effects of pain around or inside the eye, brow ache and blurred vision. If we are using more then one eye drop in ... Jamaica Gleaner

A prospective ultrasound biomicroscopy evaluation of changes in...  -  Jun 16, 2008
All patients received the same preinterventional regimen that consisted of three drops of pilocarpine 2% half an hour before the intervention and one drop ... Nature.com

Brand Names/Synonyms:
Pilocarpine is also known by the following brand names and/or synonymsAdsorbocarpine; Akarpine; Almocarpine; Ami-Pilo; Amistura P; Beta-Pilocarpine Hydrochloride; Epicar; HSDB 3163; Isopto Carpine; Isoptocarpine; Mi-Pilo; Mi-Pilo Ophth Sol; Minims Pilocarpine; Miocarpine; Mistura P; NSC5746; Ocu-Carpine; Ocusert P 20; Ocusert Pilo; Ocusert Pilo-20; Ocusert Pilo-40; P.V. Carpine Liquifilm; Pilagan; Pilocar; Pilocar Smp; Pilocarpal; Pilocarpin; Pilocarpine; Pilocarpine Chloride; Pilocarpine Hcl; Pilocarpine Hydrochloride; Pilocarpine Monohydrochloride; Pilocarpine Muriate; Pilocarpine [Usan:Ban:Jan]; Pilocarpine, Hydrochloride; Pilocarpine, Monohydrochloride; Pilocarpine-; Pilocarpol; Pilocel; Pilokarpin; Pilokarpin Monohydrochloride; Pilokarpol; Pilomiotin; Pilopine Hs; Piloptic-&Frac12;; Piloptic-1; Piloptic-2; Piloptic-3; Piloptic-4; Piloptic-6; Piloptic-½; Pilostat; Pilovisc; Salagen; Sno Pilo; Spersacarpine; Spersacarpine Hydrochloride; Syncarpine

Drug Category:
Pilocarpine is categorized under the following by the FDA: Cholinergic Agents; Muscarinic Agonists; Miotics; ATC:N07AX01; ATC:S01EB01

Dosage Forms:
DROPS; GEL; IMPLANT; LIQUID; SOLUTION

Absorption:
There was a decrease in the rate of absorption of pilocarpine from SALAGEN Tablets when taken with a high fat meal by 12 healthy male volunteers

Interactions:
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Chemical IUPAC Name:
3-ethyl-4-[(3-methylimidazol-4-yl)methyl]oxolan-2-one





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