Piperacillin

This page contains recent news articles, when available, and an overview of Piperacillin but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Piperacillin
(when available)

Pharmacology and use:
Piperacillin is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. The name "penicillin" can either refer to several variants of penicillin available, or to the group of antibiotics derived from the penicillins. Piperacillin has in vitro activity against gram-positive and gram-negative aerobic and anaerobic bacteria. The bactericidal activity of Piperacillin results from the inhibition of cell wall synthesis and is mediated through Piperacillin binding to penicillin binding proteins (PBPs). Piperacillin is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, and cephalosporinases and extended spectrum beta-lactamases. For the treatment of polymicrobial infections.

Mechanism Of Action:
By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, Piperacillin inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that Piperacillin interferes with an autolysin inhibitor.

News Articles on Piperacillin

Bitter pill  -  ‎Dec 16, 2009‎
Tazobactam Piperacillin or Tazo-Pip, an antibacterial combination product was to be another key growth driver for Orchid in both the US and EU, ... Daily News & Analysis

Ocular Vaccinia With Severe Restriction of Extraocular Motility  -  ‎Dec 14, 2009‎
Treatment with intravenous vancomycin hydrochloride, clindamycin phosphate, and piperacillin sodium with tazobactam sodium was started. Figure 1. ... Archives of Ophthalmology

Generic Levaquin Is in the Pipeline  -  ‎Dec 14, 2009‎
...finds that the patent expiries of three blockbuster antibiotics—levofloxacin, moxifloxacin and piperacillin/tazobactam—will be the primary factors ... Lawyers and Settlements

Endringer i byttelisten gjeldende fra 1. januar 2010  -  ‎Dec 30, 2009‎
Byttegruppene med første generika inkluderer bisoprolol tabletter, kalsipotriol krem og piperacillin pulver til injeksjons-/infusjonsvæske. ... Statens legemiddelverk

US court rules in favour of Orchid  -  ‎Nov 2, 2009‎
The company further said it is pleased with this result and will protect abbreviated new drug applications (ANDA) for its Piperacillin and Tazobactam ... Trading Markets (press release)

Orchid incurs lower net loss of Rs 13 cr in Q2  -  ‎Oct 31, 2009‎
The approval of our Piperacillin-Tazobactam injection ANDAs by the US FDA marks the start of yet another robust revenue cycle. The approval of this product ... pharmabiz.com

A Survivor's Tale: How a Landslide Leveled an Entire Village in Minutes  -  ‎Oct 31, 2009‎
The Piperacillin Sodium (Tazobactam Sodium) of which Erlina needs an injection every eight hours ran out at the BGH on Oct. 16. It costs P1,800 at BGH and ... Bulatlat

Astellas and Theravance Announce Submission of Telavancin MAA for the ...  -  ‎Oct 31, 2009‎
...to the Gram-positive organisms for which study medication therapy was used, aztreonam, piperacillin-tazobactam, and/or metronidazole were allowed. ... PR-USA.net (press release)

Orchid Chemicals gets Canadian nod for combo injection  -  Jun 24, 2008
BO said on Tuesday it had secured Canadian regulatory approval to sell combination antibiotic piperacillin-tazobactam injection in that country. ... Reuters Canada

Orchid gets MHPRA approval for API.  -  Jan 23, 2007
The company would be formulating Piperacillin -- Tazobactam in its state-of-the-art dosage form plant at Irungattukottai, Chennai, which is also under the ... Free with registration - Economic Times - AccessMyLibrary.com

Orchid receives EU approvals for piperacillin tazobactam injection  -  Aug 4, 2008
Orchid Chemicals & Pharmaceuticals (Orchid), a Chennai-based generic pharma major, today announced that it has received approvals of its marketing ... Myiris.com

Drug Stability; Piperacillin and tazobactam show comparable stability...  -  Nov 22, 2005
2005 NOV 22 - (NewsRx.com) -- Piperacillin and tazobactam show comparable stability in PVC and non-PVC bags, with increased stability observed at slightly ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

Orchid Chemicals gearing up for European foray  -  Jan 31, 2007
In addition to these Orchid will launch Pencillin-based product, Tazobactum-Piperacillin, in Europe, seeking a slice of the Rs 1100-crore market. ... Hindu Business Line

… -associated pneumonia with piperacillin-tazobactum and amikacin vs ...  -  Jul 1, 2007
Many authorities recommend piperacillin-tazobactam as the most effective agent in the ... sup] [6] However, the widespread use of piperacillin-tazobactam as ... Free with registration - Indian Journal of Critical Care Medicine - AccessMyLibrary.com

Moxifloxacin QD similar to piperacillin-tazobactam and amoxicillin- …  -  Sep 1, 2006
Intravenous (IV) moxifloxacin followed by oral (PO) moxifloxacin, both dosed once-daily, is at least as effective in the treatment of complicated ... $4.95 - Formulary - ECNext

Abstract and Introduction  -  Mar 29, 2006
Conclusion: The piperacillin-tazobactam shortage was associated with significant ... In 2002, a national shortage of piperacillin-tazobactam took place. ... Medscape

Tazobactam Plus Piperacillin Shows Benefits in Children With Lower …  -  Apr 9, 2007
By Chris Berrie. MUNICH, GERMANY -- April 9, 2007 -- Combinations of a beta-lactamase inhibitor with a penicillin produce a satisfactory therapeutic outcome ... DG News

Article: Ertapenem effective for diabetic foot infections: once-daily...  -  Feb 15, 2005
For the primary ... group and 2.1% in the piperacillin plus tazobactam group. ... He recommended piperacillin plus tazobactam or ticarcillin plus ... Pay-Per-View - Internal Medicine News - HighBeam Research

J&J says doripenem studies positive  -  Sep 18, 2007
Johnson & Johnson claims the study showed the bacteria were more resistant to treatment combining piperacillin and tazobactam compared with doripenem. ... ABCmoney.co.uk

Who should receive antibiotic prophylaxis before ERCP?  -  Jun 5, 2008
In another study, 9 the same antibiotic (piperacillin) or placebo was given to ... (1996) Biliary excretion of ciprofloxacin and piperacillin in the ... Nature.com

Penicillins (Systemic).  -  Feb 1, 2006
Piperacillin (pi-PER-a-sill-in) 15.Pivampicillin (piv-am-pi-SILL-in )(*) 16.Pivmecillinam (piv-me-SILL-in-am)(*) 17. Ticarcillin ( tye-kar-SILL-in) ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Article: 3 cos sue Wyeth over Zosyn patent. - Economic Times (New...  -  Feb 4, 2007
Drug Administration approval to market ZOSYN(TM) (piperacillin ... ZOSYN combines Lederle's piperacillin, a broad ... a powerful beta-lactamase inhibitor. ... Pay-Per-View - Economic Times - HighBeam Research

The clinical impact of antibacterial prophylaxis and cycling antibioti...  -  Feb 26, 2007
Empiric antibiotics were started (piperacillin and gentamicin) at initial ... As piperacillin/tazobactam was not routinely tested for resistance, ... Nature.com

Antibiotic Cycling  -  Mar 1, 2005
Ciprofloxacin+/-clindamycin, piperacillin/tazobactam, carbapenem, and cefepime+/-clindamycin were rotated, and the effects of antibiotic rotation on patient ... Free with registration - Critical Care Alert - AccessMyLibrary.com

Antibacterial Agents; Moxifloxacin is effective treatment for...  -  Oct 3, 2006
2006 OCT 3 - (NewsRx.com) -- Moxifloxacin was as effective as piperacillin-tazobactam and amoxicillin-clavulanate for the treatment of complicated ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

Orchid eyes $60 mn from new facility  -  Dec 3, 2005
The Tazobactum and Piperacillin active pharmaceutical ingredients, which, at present, are manufactured at Orchid's Aurangabed API plant, will be dissolved ... Rediff

Antibiotics; Studies from the United States and Spain describe new …  -  Oct 23, 2006
Study 1: Moxifloxacin was as effective as piperacillin-tazobactam and amoxicillin-clavulanate for the treatment of complicated intra-abdominal infections. ... Pay-Per-View - Clinical Trials Week - Factiva, from Dow Jones

FDA Approves New Indication for INVANZ(R) (ertapenem) for the …  -  Nov 14, 2005
Of those patients that were described as evaluable (INVANZ n=204; and piperacillin/tazobactam n=202), 75.0 percent of the patients taking INVANZ had a ... Free with registration - Business Wire - AccessMyLibrary.com

Doripenem Deemed Effective for Treatment of Hospital-Acquired …  -  Sep 27, 2007
Doripenem demonstrated an 81.3% clinical cure rate compared to a 79.8% cure rate seen with the combination of piperacillin/tazobactam. ... news Stories

Once-daily ertapenem good for diabetic foot infections.(Clinical...  -  Mar 1, 2005
Patients were randomized to intravenous treatment with either 1 g of ertapenem once daily, or 3.375 g of piperacillin plus tazobactam every 6 hours. ... Free with registration - Skin & Allergy News - AccessMyLibrary.com

VEB-1 in Achromobacter xylosoxidans from cystic fibrosis patient,...  -  Nov 1, 2006
A. xylosoxidans is innately resistant to many antimicrobial drugs (2), except piperacillin, piperacillin-tazobactam, and imipenem, and moderately ... Free with registration - Emerging Infectious Diseases - AccessMyLibrary.com

Antibacterials Getting More Play in Teaching Hospitals  -  Nov 10, 2008
Average use of piperacillin-tazobactam increased by 84%, from 38 days of therapy per 1000 patient-days in 2002 to 75 in 2005 and 70 in 2006. ... MedPage Today

Beta-Lactam Antibiotics; beta-lactam impact on VRE colonization...  -  Feb 2, 2005
..."Both piperacillin-tazobactam and ceftriaxone inhibited colonization by an enterococcal strain devoid of low-affinity penicillin-binding protein-5 ... Pay-Per-View - Immunotherapy Weekly - Factiva, from Dow Jones

Antibiotic and Antiviral Drug Classes  -  Apr 14, 2008
Certain penicillins used against Pseudomonas aeruginosa include ticarcillin and piperacillin. Piperacillin is more effective than ticarcillin. ... New York Times

Atypical infections in tsunami survivors.  -  Oct 1, 2005
After 6 weeks of treatment with piperacillin-tazobactam, the patient was discharged from the hospital. One month later, the patient returned to the hospital ... $4.95 - Emerging Infectious Diseases - ECNext

Ertapenem effective for diabetic foot infections: once-daily ertapenem...  -  Feb 15, 2005
Patients were randomized to intravenous treatment with either 1 g of ertapenem once daily, or 3.375 g of piperacillin plus tazobactam every 6 hours. ... Pay-Per-View - Internal Medicine News - Factiva, from Dow Jones

Avelox as Effective as Multi-Dose Combination Therapy for Intra- …  -  Jul 25, 2006
...(the primary efficacy endpoint) as patients who took a standard regimen of IV piperacillin-tazobactam followed by oral amoxicillin-clavulanate (78%). ... DG News

A randomized comparison of empiric or pre-emptive antibiotic therapy ...  -  Apr 30, 2007
In autologous HSCT recipients, half of whom had solid tumours, oral norfloxacin begun at admission was compared with piperacillin–tazobactam begun on the ... Nature.com

Article: Once-daily ertapenem good for diabetic foot infections.(Clini...  -  Mar 1, 2005
The most common adverse events in both groups were diarrhea ... treated with piperacillin plus tazobactam. BY MITCHEL L. ZOLER ... ... Pay-Per-View - Skin & Allergy News - HighBeam Research

Avelox As Effective As Multi-dose Combination Therapy For Intra- …  -  Jul 28, 2006
...primary efficacy endpoint) as patients who took a standard regimen of IV piperacillin-tazobactam followed by oral amoxicillin-clavulanate (78 percent). ... Medical News Today - Medical News Today (press release)

Ertapenem effective for diabetic foot infection: response to the...  -  Feb 1, 2005
Ertapenem effective for diabetic foot infection: response to the single drug was similar to that of the combination of piperacillin and tazobactam. Pay-Per-View - Family Practice News - HighBeam Research

Penicillins and Beta-Lactamase Inhibitors (Systemic ).  -  Aug 1, 2006
Depakene) -- Use of these medicines with piperacillin and tazobactam ... to have bleeding when receiving piperacillin and tazobactam combination or ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Beta-Lactam Antibiotics; beta-lactam impact on VRE colonization...  -  Feb 4, 2005
..."Both piperacillin-tazobactam and ceftriaxone inhibited colonization by an enterococcal strain devoid of low-affinity penicillin-binding protein-5 ... Pay-Per-View - Drug Week - Factiva, from Dow Jones

Ertapenem resistance of Escherichia coli.(DISPATCHES)(Clinical report)  -  Feb 1, 2007
TEM-1) Amoxicillin >256 2 Amoxicillin + CLA 64 2 Ticarcillin >256 2 Ticarcillin + CLA 128 2 Piperacillin 64 1 Piperacillin + TZB 32 1 Cephalotin 4 4 ... $4.95 - Emerging Infectious Diseases - ECNext

Antibiotika-Therapie: Neubewertung der Beta-Laktam-Inhibitoren  -  May 6, 2005
Bei der vergleichenden Testung von Piperacillin/Sulbactam und ... Bei Piperacillin-intermediären E.-coli-Stämmen ergibt Pip/Sul mit 8 mg Sulbactam oft eine ... Deutsches Ärzteblatt

Antibiotic monotherapy effective after ruptured appendicitis  -  Jul 7, 2007
Monotherapy regimens included piperacillin/tazobactam, meropenem, ... Similarly, treatment with piperacillin/tazobactam was associated with reduced odds of ... AAP News - AAP News (subscription)

Schering-Plough; Recent developments from Schering-Plough detailed  -  Dec 5, 2006
...valid to assess efficacy (183 Avelox/196 piperacillin-tazobactam). Patient baseline medical characteristics were similar for the two treatment groups. ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

Household Antibacterial Product Use May Promote Microbial Resistance  -  Jul 3, 2008
...against trimethoprim/sulfamethoxazole, piperacillin/tazobactam, and ceftriaxone; for Pseudomonas fluorescens/putida against piperacillin/tazobactam and ... Medscape

Carbapenemase-producing Enterobacteriaceae, US rivers.(Research)  -  Feb 1, 2005
Ticarcillin + CLA 16 >256 16 Piperacillin 16 >256 8 Piperacillin + TZB 4 ... 4 Ticarcillin 256 4 Ticarcillin + CLA 32 4 Piperacillin 128 2 Piperacillin ... $4.95 - Emerging Infectious Diseases - ECNext

Viaman Pharma terminates licensing agreement with Shanghai drug …  -  Jul 24, 2007
Ltd. for its antibacterial piperacillin sodium and sulbactam sodium compound, ... Guangzhou Viaman, the patent owner of the piperacillin sodium and ... $4.95 - China Business News - ECNext

Unexpected occurrence of plasmid-mediated quinolone resistance …  -  Feb 1, 2008
...amoxicillin-clavulanate (20/10 [micro]g), ticarcillin-clavulanate (75/10 [micro]g), piperacillin (75 [micro]g), piperacillin-tazobactam (75/10 [micro]g) ... Free with registration - Emerging Infectious Diseases - AccessMyLibrary.com

IDSA releases guidelines for the diagnosis and treatment of skin and...  -  Oct 1, 2006
...given intravenously Mixed infection Ampicillin/sulbactam 1.5 to 3 g every six to eight hours, (Unasyn) given intravenously or piperacillin/ 3.37 g every ... Free with registration - American Family Physician - AccessMyLibrary.com

Catheter-related bacteremia and multidrug-resistant Acinetobacter...  -  Feb 1, 2007
...([dagger]) AS, ampicillin-sulbactam; PI, piperacillin; PT, piperacillin-tazobactam; CE, cefopime; CT, cefotaxamine; CA, ceftazidime; CF, ceftriaxone; AT, ... $4.95 - Emerging Infectious Diseases - ECNext

FDA Approvals: Exjade, Oncaspar, Invanz  -  Nov 17, 2005
In the study, patients received either ertapenem, 1 g daily, or piperacillin/tazobactam, 3.375 g every six hours for a minimum of five days, ... Medscape

Antimicrobial Resistance Patterns Of Urinary Tract Pathogens And …  -  Sep 28, 2008
80% of those E. coli in that year were also susceptible to gentamicin, 90% to cefuroxime and amikacin and 60% to piperacillin. By 2006 those similar strands ... Medical News Today - Medical News Today (press release)

Two probable cases of serious drug interaction between clarithromycin...  -  Aug 1, 2005
He was given intravenous 4.5 g piperacillin-tazobactam every 6 hours and 500 mg oral ... Intravenous piperacillin-tazobactam was stopped on day 9. ... Free with registration - Southern Medical Journal - AccessMyLibrary.com

Diagnosis and management of acute pyelonephritis in adults.  -  Mar 1, 2005
Piperacillin (Pipracil) Every 6 hours -- Piperacillin-tazobactam Every 6 to 8 ... I.V.) 0.5 g Piperacillin (Pipracil) 3 g Piperacillin-tazobactam 3.375 ... $4.95 - American Family Physician - ECNext

Antibiotic cycling to decrease bacterial antibiotic resistance: a 5...  -  May 28, 2007
Antibiotic cycling was implemented in January 1999 at our hematology–oncology unit, alternating piperacillin-tazobactam (pip-tazo) and cefepime in 3 months ... Nature.com

Epidemiology of bacteremia and factors associated with multi-drug- …  -  Apr 16, 2007
...carbapenems or piperacillin-tazobactam. Among 411 HSCT, fever occurred in 333, and 91 developed bacteremia (118 isolates): 47% owing to Gram-positive, ... Nature.com

IDSA releases guidelines for the diagnosis and treatment of skin and...  -  Oct 1, 2006
...given intravenously Mixed infection Ampicillin/sulbactam 1.5 to 3 g every six to eight hours, (Unasyn) given intravenously or piperacillin/ 3.37 g every ... $4.95 - American Family Physician - ECNext

Group C streptococcal sepsis complicating Fournier gangrene.(Case …  -  Sep 1, 2005
An insulin infusion and piperacillin-tazobactam were administered. ... He was discharged home on piperacillin-tazobactam with a wound care regimen and ... $4.95 - Southern Medical Journal - ECNext

Two probable cases of serious drug interaction between clarithromycin...  -  Aug 1, 2005
He was given intravenous 4.5 g piperacillin-tazobactam every 6 hours and 500 mg oral ... Intravenous piperacillin-tazobactam was stopped on day 9. ... $4.95 - Southern Medical Journal - ECNext

Respiratory hyperinfection with Strongyloides stercoralis in a...  -  Feb 26, 2007
The patient was started on empirical broad-spectrum antibiotics, initially amoxicillin and clavulanic acid for 5 days, and then piperacillin and tazobactam ... Nature.com

Biventricular assist device placement and immunosuppression as...  -  Apr 11, 2005
A combination of piperacillin and tazobactam was prescribed for broad ... The presence of pulmonary infiltrates led to piperacillin and tazobactam therapy ... Nature.com

Inquilinus limosus in patients with cystic fibrosis, Germany.(Dispatch...  -  Mar 1, 2005
...antimicrobial susceptibility profile with high MICs for cotrimoxazole, most aminoglycosides, ampicillin, cefotaxime, and piperacillin/tazobactam. ... $4.95 - Emerging Infectious Diseases - ECNext

Efficacy of once-daily Avelox for complicated abdominal infections …  -  Sep 29, 2006
In one trial, the comparator treatment was IV piperacillin-tazobactam (3.0/0.375 g, every 6 hours) followed by oral amoxicillin-clavulanic acid (800/114 mg, ... eurekalert.org

Press Release: Validus Pharmaceuticals, Inc. Announces Acquisition of...  -  May 14, 2007
Article: American Pharma Partners generic piperacillin OKed ... ... The 40g vial joins APP's current offering of piperacillin for injection in 2g, ... Pay-Per-View - PR Newswire - HighBeam Research

Efficacy of Once-Daily Moxifloxacin in Treating Complicated Intra- …  -  Oct 13, 2006
In one trial, the comparator treatment was IV piperacillin-tazobactam (3.0/0.375 g, every 6 hours) followed by oral amoxicillin-clavulanic acid (800/114 mg, ... DG News

FDA Approves New Indication for Avelox (moxifloxacin HCl) for...  -  Nov 30, 2005
...once daily was as effective as the widely used IV therapy piperacillin-tazobactam four times daily followed by oral amoxicillin-clavulanate twice daily. ... DG News

Sensex falters again; Orchid, Thermax surge higher  -  Aug 4, 2008
Orchid Chemicals & Pharmaceuticals Ltd has informed BSE that it has received EU approvals for its Piperacillin Tazobactam injection. ... सिफी - सिफी

Researchers Review Efficacy and Safety of Cefepime: Presented at …  -  Apr 3, 2006
...ceftriaxone (n = 4) and piperacillin/tazobactam (n = 4). ... RR, 1.20; 95% CI, 0.96- 1.50; piperacillin/tazobactam, RR, 2.14; 95% CI, 1.17-3.89; ... DG News

PENICILLIN (Oral route, Injection route, Intravenous route, Intramuscu...  -  May 1, 2007
For piperacillin: * For bacterial infections: * For injection dosage form: * Adults and teenagers -- 3 to 4 grams, injected into a vein or muscle every four ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

INVANZ approved for complicated foot infection in diabetic patients.(...  -  Feb 1, 2006
Patients either received INVANZ 1 gram daily or piperacillin/tazobactam at the recommended dose. The study demonstrated 75% of patients receiving INVANZ had ... Free with registration - Journal of Drugs in Dermatology - AccessMyLibrary.com

VIM-1 metallo-[beta]-lactamase in Acinetobacter baumannii.( …  -  Jun 1, 2006
...ceftazidime, cefepime, imipenem, meropenem, and piperacillin), ... piperacillin/ tazobactam), aminoglycosides (amikacin, gentamicin, netilmicin, ... Free with registration - Emerging Infectious Diseases - AccessMyLibrary.com

Are Double-Beta Lactam Combinations Appropriate in the NICU?  -  Dec 3, 2007
...[1] In febrile granulocytopenic patients, DBL combinations of cefoperazone or ceftazidime plus piperacillin were clinically as effective as imipenem. ... Medscape

The role of carbapenems in initial empiric therapy of serious gram- …  -  Jul 1, 2007
Carmeli et al (13) showed that among four antipseudomonal agents (ciprofloxacin, ceftazidime, imipenem, and piperacillin), the likelihood of resistance ... Free with registration - Formulary - AccessMyLibrary.com

Fludrocortisone (Systemic).  -  Oct 27, 2005
Mezlin) Piperacillin (eg, Pipracil) or Piperacillin and tazobactam (eg, Zosyn) or Salicylates or Sirolimus (eg, Rapamune) or Sodium bicarbonate (eg, ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Approach to the Patient With Mild-to-Moderate Acute Pancreatitis?  -  Nov 29, 2006
The patient was started on 2 antibiotics, piperacillin and tazobactam, presumably on an empiric basis, as we are given no information to suggest positive ... Medscape

Gatifloxacin can disturb glucose homeostasis.(Infectious Diseases)  -  Feb 1, 2005
It was a small study, with 134 patients in the gatifloxacin arm and 82 in the piperacillin arm, and their glucose levels were checked only in the morning. ... Free with registration - Internal Medicine News - AccessMyLibrary.com

Preventing strategy of multidrug-resistant Acinetobacter baumanii …  -  Nov 5, 2007
Antibiotic susceptibility was determined for the following antimicrobial agents: piperacillin, piperacillin/tazobactam, ticarcillin/clavulanic acid, ... European Journal of Cardio-Thoracic...

VIM-2-producing Pseudomonas putida, Buenos Aires.(Letter to the...  -  Apr 1, 2007
Argentina MIC ([micro]g/mL) Drug Isolate 1 Isolate 2 Imipenem 32 64 Meropenem 64 64 Ertapenem 128 128 Piperacillin 64 64 Piperacillin-tazobactam 32 32 ... Free with registration - Emerging Infectious Diseases - AccessMyLibrary.com

Acinetobacter Baumannii; Multiresistant Acinetobacter baumannii clone...  -  Feb 8, 2005
..."All the isolates tested were highly resistant to ampicillin, piperacillin, piperacillin/tazobactam, ceftazidime, cefotaxime, gentamicin and ciprofloxacin, ... Pay-Per-View - TB & Outbreaks Week - Factiva, from Dow Jones

Acinetobacter Baumannii; Multiresistant Acinetobacter baumannii clone...  -  Feb 9, 2005
..."All the isolates tested were highly resistant to ampicillin, piperacillin, piperacillin/tazobactam, ceftazidime, cefotaxime, gentamicin and ciprofloxacin, ... Pay-Per-View - Immunotherapy Weekly - Factiva, from Dow Jones

Two probable cases of serious drug interaction between clarithromycin...  -  Aug 1, 2005
He was given intravenous 4.5 g piperacillin-tazobactam every 6 hours and 500 mg oral ... Intravenous piperacillin-tazobactam was stopped on day 9. ... Pay-Per-View - Southern Medical Journal - HighBeam Research

Antibiotics in the ICU: Cycling, Mixing, or Personalization?  -  Dec 1, 2006
...anti-pseudomonal cephalosporins, and piperacillin-tazobactam. This was followed by three 4 month cycles of these same agents, but in reverse order. ... Pay-Per-View - Infectious Disease Alert - Factiva, from Dow Jones

Acinetobacter Baumannii; Multiresistant Acinetobacter baumannii clone...  -  Feb 13, 2005
..."All the isolates tested were highly resistant to ampicillin, piperacillin, piperacillin/tazobactam, ceftazidime, cefotaxime, gentamicin and ciprofloxacin, ... Pay-Per-View - Medical Devices & Surgical Technology... - Factiva, from Dow Jones

Do topical antibiotics improve wound healing?(CLINICAL INQUIRIES: …  -  Feb 1, 2007
A small but well-designed study of 62 patients with major contaminated wounds failed to show any additional benefit when topical piperacillin/tazobactam ... $4.95 - Journal of Family Practice - ECNext

Stenotrophomonas maltophilia in salad.(LETTERS)(Letter to the Editor)  -  Jul 1, 2005
Susceptibilities of 9 confirmed isolates to ceftazidime, chloramphenicol, colistin sulfate, gentamicin, minocycline, piperacillin/tazobactam, ... $4.95 - Emerging Infectious Diseases - ECNext

Guidelines for managing hospital-acquired pneumonia.(CLINICAL …  -  Jun 1, 2005
...or a [beta]-lactam/ss-lactamase inhibitor (piperacillin-tazobactam) plus an ... inhibitor 4.5g q6h Piperacillin-tazobactam Aminoglycosides Gentamicin 7 ... $4.95 - Journal of Respiratory Diseases - ECNext

Osteomyelitis of parietal bone in melioidosis.(Case study)  -  Aug 1, 2007
The isolate was sensitive to piperacillin, piperacillin-tazobactam, ceftazidime, imipenem, meropenem, and chloramphenicol. ... $4.95 - Emerging Infectious Diseases - ECNext

An 18-year-old man with rapidly progressive multiorgan failure after...  -  Jul 1, 2006
Treatment with piperacillin/tazobactam and prednisolone was started. ... The prednisolone was tapered, and piperacillin/tazobactam was stopped, ... $4.95 - Chest - ECNext

J&J's doripenem fares well vs NP and VAP.  -  Oct 1, 2007
In clinically-evaluable patients, doripenem demonstrated an 81.3% clinical cure rate versus 79.8% seen with the combination of piperacillin/tazobactam. ... $4.95 - Pharma Marketletter - ECNext

VIM-2-producing Pseudomonas putida, Buenos Aires.(Letter to the...  -  Apr 1, 2007
Argentina MIC ([micro]g/mL) Drug Isolate 1 Isolate 2 Imipenem 32 64 Meropenem 64 64 Ertapenem 128 128 Piperacillin 64 64 Piperacillin-tazobactam 32 32 ... $4.95 - Emerging Infectious Diseases - ECNext

Bordetella petrii clinical isolate.(DISPATCHES)  -  Jul 1, 2005
...gentamicin, ceftriaxone, and piperacillin/tazobactam. ... Penicillin >32 Ampicillin >256 Piperacillin/tazobactam 2 Ceftriaxone >32 Cefotaxime ... $4.95 - Emerging Infectious Diseases - ECNext

An unusual cause of acute abdomen following allogeneic transplantation...  -  Mar 3, 2008
Antibiotics were changed from piperacillin–tazobactam and gentamicin to meropenem and amikacin with a temporary improvement. However, 7 days later, ... Nature.com

Keratinocyte growth factor is effective in the prevention of intestina...  -  Jun 16, 2008
11 Patients with neutropenic fever received empirically broad-spectrum antibiotics (piperacillin-tazobactam with or without amikacin). ... Nature.com

Market Live from BSE - NSE, Latest Market Commentary | Economic …  -  Aug 4, 2008
2:30 pm: Orchid Chemicals & Pharmaceuticals has received approvals of its marketing authorization for Piperacillin and Tazobactam for Injection for ... Economic Times

A fatal metastasis of Klebsiella pneumoniae to the lungs  -  Nov 11, 2008
He was treated on an emergency basis with intravenous fluids, vasopressors and infusion of piperacillin with tazobactam. A 2:1 heart block developed and a ... Nature.com

A case of tuberous sclerosis complex that progressed to end-stage...  -  Jul 16, 2008
...combined with a steroid to treat relative adrenal insufficiency) with appropriate antibiotic coverage (piperacillin–tazobactam and vancomycin). ... Nature.com

Article: FDA approves generic IV ciprofloxacin.(News) - Family...  -  Sep 15, 2006
Article: Cipro IV: In combination with piperacillin to treat ... Formulary; February 1, 1998 ; 406 words ...The FDA has approved a new indication for the IV ... Pay-Per-View - Family Practice News - HighBeam Research

Article: Genetic forms of intravenous ciprofloxacin gain approval.(New...  -  Oct 1, 2006
Article: Cipro IV: In combination with piperacillin to treat ... Formulary; February 1, 1998 ; 406 words ...The FDA has approved a new indication for the IV ... Pay-Per-View - Skin & Allergy News - HighBeam Research

Allogeneic hematopoietic SCT performed in non-HEPA filter rooms:...  -  Sep 15, 2008
First-line antibiotic cover during conditioning consisted of piperacillin–tazobactam and amikacin +/- teicoplanin. Imipenem or meropenem was started as ... Nature.com

Orchid to line up new drugs  -  Jul 19, 2007
Mr. Rao was confident that Orchid would get the USFDA nod for the combination product — Tazobactam and Piperacillin — a penicillin-based injectible antibiotic. Hindu

Orchid gets US FDA nod for Cefdinir  -  Jul 25, 2007
The third product is a penicillin-based antibiotic called Tazobactum-Piperacillin. Orchid had counted on earning revenues of $60 million (Rs 250 crore) from ... Hindu Business Line

Fludarabine, cyclophosphamide and horse antithymocyte globulin …  -  Mar 6, 2006
First line cover consisted of piperacillin-tazobactam (Zosyn), amikacinteicoplanin (Targocid). Systemic antifungals were added if fever persisted for more ... Nature.com

Refractory hyponatremia  -  Sep 20, 2006
Her outpatient medications at the time of admission included intravenous vancomycin and piperacillin/tazobactam, rifampin, amitriptyline at a stable dose ... Nature.com

A case of mediastinitis following botulinum toxin type A treatment...  -  Mar 2, 2007
...owing to continued fever and was started on total parenteral nutrition and treatment with intravenous piperacillin–tazobactam (3.375 g every 6 h), ... Nature.com

Orchid mulls slew of product launches  -  Jul 17, 2007
Mr. Rao was confident that Orchid would get the US FDA nod for the combination product - Tazobactam and Piperacillin, penicillin-based injectible ... Hindu

Brand Names/Synonyms:
Piperacillin is also known by the following brand names and/or synonymsCCRIS 7362; CHEMBANK963; PIPERACILLIN; Piperacillin; Piperacillin Anhydrous; Pipracil

Drug Category:
Piperacillin is categorized under the following by the FDA: Anti-bacterial Agents; Penicillins; ATC:J01CA12

Dosage Forms:
POWDER FOR SOLUTION

Absorption:
Not Available

Interactions:
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Chemical IUPAC Name:
7-[2-(4-ethyl-2,3-dioxo-piperazin-1-yl)carbonylamino-2-phenyl-acetyl]amino-3,3-dimethyl-6-oxo-2-thia-5-azabicyclo[3.2.0]heptane-4-carboxylate





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