Pirenzepine

This page contains recent news articles, when available, and an overview of Pirenzepine but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Pirenzepine
(when available)

Pharmacology and use:
Pirenzepine belongs to a group of medications called antispasmodics/anticholinergics. These medications are used to relieve cramps or spasms of the stomach, intestines, and bladder. Pirenzepine is used to treat duodenal or stomach ulcers or intestine problems. It can be used together with antacids or other medicine in the treatment of peptic ulcer. It may also be used to prevent nausea, vomiting, and motion sickness. For the treatment of peptic ulcer; Gastric ulcer; Duodenal ulcer

Mechanism Of Action:
Pirenzepine is a muscarinic receptor antagonist and binds to the muscarinic acetylcholine receptor. The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.

News Articles on Pirenzepine

Medication slows myopia progression  -  Aug 26, 2008
26 (UPI) -- Daily treatment with the medication pirenzepine can slow the rate of progressive myopia, or nearsightedness, in children, US researchers said. ... United Press International

Gel helps slow progression of myopia in kids  -  Sep 4, 2008
During the study, 37 percent of children using pirenzepine met 0.75 diopters ... The new results show that pirenzepine-a related drug with fewer side ... Newspost Online

> I think that we both agree that letting kids read at 4 inches is a...  -  Oct 27, 2006
Why plus glasses with Pirenzepine? Pirenzepine doesn't affect. > accommodation. ... Myopia will not disappear with Pirenzepine. There are many difficult ... earthvision.net

Nonsurgical treatments to prevent myopia development may be coming  -  Dec 1, 2005
Pirenzepine is about as effective as atropine with many fewer side effects. ... Pirenzepine causes less mydriasis and less cycloplegia than atropine, ... OSN SuperSite

Enhancement of memory function in aged mice by a novel derivative of ...  -  Oct 21, 2008
This LTP-like response was blocked by 0.25 M pirenzepine, a selective M1 antagonist, when applied 15 min prior to and during EUK1001 treatment (Figure 1D3). ... Nature.com

Anticholinergics/Antispasmodics (Systemic).  -  Feb 1, 2006
Pirenzepine ( peer-EN-ze-peen)(*) 13.Propantheline (proe-PAN-the-leen )(***) ... For pirenzepine For (oral) dosage form (tablets): ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Eye Gel Slows Decline In Kids' Vision  -  Aug 28, 2008
But when children are treated daily with a medication called pirenzepine, ... That means 37 percent of children using pirenzepine needed new lenses during ... KMBC.com

How to get... the perfect shadow-free eyes; What women want.(Features)...  -  Feb 5, 2008
The drug, pirenzepine, has been used for years to treat ulcers. ... Pirenzepine eye gel is undergoing trials in children aged eight to 12 in the US. ... Pay-Per-View - Daily Record - HighBeam Research

Style: Wake up call; We test five eye creams.(Features) | Article...  -  Jul 19, 2008
The drug, pirenzepine, has been used for years to treat ulcers. ... Pirenzepine eye gel is undergoing trials in children aged eight to 12 in the US. ... Pay-Per-View - Daily Record - HighBeam Research

Look Here: Treatments for Poor Vision  -  Sep 12, 2006
An eye gel based on the ulcer drug pirenzepine is in clinical trials and looks quite promising, says Dominick Maino of the Illinois Eye Institute. ... Washington Post

RS-86, donepezil, muscarinic, acetylcholine, REM, sleep  -  Apr 26, 2005
...blocked by the M 2 /M 4 antagonist methoctramine but not by the M 1 /M 4 antagonist pirenzepine, indicating M 2 mAChR mediation (Coleman et al, 2004). ... Nature.com

G q -coupled receptors as mechanosensors mediating myogenic …  -  Nov 6, 2008
...(G) Comparison of TRPC6 current suppression by atropine (1 M), pirenzepine (1 M), diphenhydramine (100 M), losartan (1 M) and candesartan, 'Cand', ... Nature.com

Global Orthokeratology Symposium 2005  -  Oct 7, 2005
Pirenzepine shows some reduction in axial length change but has systemic complications. The safety of orthokeratology was covered in a later session and ... Optician Online

Article: Scientists develop 'safe' test for Down's syndrome ; Home...  -  Feb 2, 2007
Trials have begun, on 24 children in the United States, of a gel containing a drug called pirenzepine, formerly used as a treatment for stomach ulcers. ... Pay-Per-View - Independent - London - HighBeam Research

Peptic ulcer.(Disease/Disorder overview)  -  May 1, 2006
Bianchi Porro G, Petrillo M, Lazzaroni M et al: Comparison of pirenzepine and carbenoxolone in the treatment of chronic gastric ulcer: a double-blind ... Free with registration - AltCareDex Medicine Modality - AccessMyLibrary.com

Agonist activation of cytosolic Ca2+ in subfornical organ cells...  -  Apr 1, 2005
...antagonist atropine and with the more selective muscarinic receptor antagonists pirenzepine and 4-diphenylacetoxy-N-methylpiperdine methiodide (4-DAMP). ... AJP-Regul Integr Comp Physiology...

Endocrinology; Vasostatins exert cardiotropic action in fish  -  Jan 10, 2005
PTx) or M1 muscarinic receptors (Pirenzepine) or calcium (Lantanum and Diltiazem) and potassium (Ba2+, 4-aminopyridine, tetraethylammonium, ... Pay-Per-View - Cardiovascular Week - Factiva, from Dow Jones

๋‹น์‹ ์?˜ ๊ฑด๊ฐ•๊ฐ€์?ด๋“œ ํ—ฌ์Šค์กฐ์„   -  Aug 28, 2008
...slows progression of myopia in children, Pirenzepine gel may help to preserve vision in nearsighted kids, J AAPOS study finds)' ์—? ๋Œ€ํ•ด ๋ณด๋?„ํ–ˆ๋‹ค. ... ๋‰ด์Šคํ”Œ๋Ÿฌ์Šค

foresighted | Definition of foresighted | HighBeam.com: Online...  -  Jul 12, 2006
Breakthrough Clinical trials show pirenzepine gel reduces progression of myopia in children Novartis Ophthalmics and Valley Forge Pharmaceuticals Inc. have ... Pay-Per-View - Oxford American College Dictionary - HighBeam Research

University of Buenos Aires, Argentina; University of Buenos Aires, …  -  Dec 19, 2006
..."All these effects were blunted by pirenzepine and mimicked the action of the authentic agonist. Concurrent analysis of the effects of nNOS, phospholipase C ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

Endocrinology; Vasostatins exert cardiotropic action in fish  -  Jan 16, 2005
PTx) or M1 muscarinic receptors (Pirenzepine) or calcium (Lantanum and Diltiazem) and potassium (Ba2+, 4-aminopyridine, tetraethylammonium, ... Pay-Per-View - Heart Disease Weekly - Factiva, from Dow Jones

Tips from the witness box.  -  Dec 9, 2005
Another more selective muscarinic antagonist, pirenzepine, has been identified - a drug more commonly known for its treatment of stomach ulcers. ... Pay-Per-View - Optician - Factiva, from Dow Jones

A pass on glasses  -  Sep 1, 2008
For the study, myopic kids were treated with either pirenzepine gel or a placebo. Both groups got more nearsighted during the two-year period, ... Chicago Daily Herald - Chicago Daily Herald

Anticholinergic Drugs and Physical Function Among Frail Elderly …  -  Sep 25, 2006
Shapovalova, KB, Kamkina, YV & Mysovskii, DA The effects of microinjection of the selective blocker of muscarinic M1 receptors pirenzepine into the ... Nature.com

A pass on glasses:.(Health Fitness) | Article from Daily Herald...  -  Sep 1, 2008
For the study, myopic kids were treated with either pirenzepine gel or a placebo. Both groups got more nearsighted during the two-year period, ... Pay-Per-View - Daily Herald - HighBeam Research

Brand Names/Synonyms:
Pirenzepine is also known by the following brand names and/or synonymsBisvanil; CHEMBANK786; Gasteril; Gastrozepin; LS-519; Leblon; P114; Pirenzepin; Pirenzepina [Inn-Spanish]; Pirenzepine; Pirenzepine Gastrozepin; Pirenzepinum [Inn-Latin]; Tabe; Ulcosan

Drug Category:
Pirenzepine is categorized under the following by the FDA: Anti-ulcer Agents; Antimuscarinics; Antispasmodics; ATC:A02BX03

Dosage Forms:
TABLET

Absorption:
Not Available

Interactions:
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Chemical IUPAC Name:
Not Available





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