Plavix

This page contains recent news articles, when available, and an overview of Plavix but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Plavix
(when available)

Pharmacology and use:
Clopidogrel, an antiplatelet agent structurally and pharmacologically similar to ticlopidine, is used to reduce atherosclerotic events such as myocardial infarction, stroke, and vascular death in patients who have had a recent stroke, recent MI, or have established peripheral vascular disease. For the reduction of atherosclerotic events (myocardial infarction, stroke, and vascular death) in patients with atherosclerosis documented by recent stroke, recent myocardial infarction, or established peripheral arterial disease

Mechanism Of Action:
The active metabolite of Clopidogrel prevents binding of adenosine diphosphate (ADP) to its platelet receptor, impairing the ADP-mediated activation of the glycoprotein GPIIb/IIIa complex. It is proposed that the inhibition involves a defect in the mobilization from the storage sites of the platelet granules to the outer membrane. No direct interference occurs with the GPIIb/IIIa receptor. As the glycoprotein GPIIb/IIIa complex is the major receptor for fibrinogen, its impaired activation prevents fibrinogen binding to platelets and inhibits platelet aggregation. By blocking the amplification of platelet activation by released ADP, platelet aggregation induced by agonists other than ADP is also inhibited by the active metabolite of Clopidogrel.

News Articles on Clopidogrel

TSMC wins patent infringement case against SMIC  -  14 Nov 2009
Sanofi will have to face an enormous knock to its revenue when its Taxotere cancer drug and Plavix blood-clot treatment begin to face competition from cheap ... itagbs.com

Plavix Patent Protected by Supreme Court Denial  -  ‎Nov 13, 2009‎
The Supreme Court denial of Apotex's petition challenging a patent on Sanofi-Aventis and Bristol-Myers Squibb's blood-thinner drug Plavix protects a patent ... FDA news (subscription)

Supreme Court Rejects Plavix Patent Challenge  -  ‎Nov 2, 2009‎
The dispute arose after the Canadian generic-drug maker Apotex Corp. applied to market a generic version of the anti-blood-clotting drug Plavix shortly ... Wall Street Journal

No Gender Gap Found for Clot-Busting Drug  -  ‎Nov 9, 2009‎
9 (HealthDay News) -- The widely used clot-dissolving drug Plavix (clopidogrel) works about the same in women as in men, an analysis of major clinical ... U.S. News & World Report

Bristol-Myers' Profit Rises, Tops Analyst Estimates  -  ‎Oct 22, 2009‎
Bristol- Myers Chief Executive Officer James M. Cornelius is trying to cut $2.5 billion in spending before generic copies of its top- selling Plavix reach ... Bloomberg

Medco plans to compare Plavix, Effient in study  -  ‎Oct 20, 2009‎
NEW YORK — Medco Health Solutions Inc. said Tuesday it will compare the blood thinner Plavix, the world's second-best selling drug, with the newer Effient. ... The Associated Press

Heart Drug Plavix Helps Men More Than Women  -  ‎Nov 10, 2009‎
...(Chicago, IL) -- The popular blood-thinning drug Plavix helps both genders reduce their chances for heart attacks and strokes, but men get more benefit than ... Ozarks First

Bristol-Myers buys rights to RA drug $85 million  -  ‎Nov 10, 2009‎
...aimed at preparing Bristol for the expected loss of revenue from Plavix, its top-selling blood-thinner, which loses patent protection in 2012. ... Reuters

New hope on finding better blood thinners  -  ‎Oct 26, 2009‎
Until now, the only oral blood thinners besides warfarin have been Plavix (clopidogrel), the world's second best-selling drug, and aspirin, ... Baltimore Sun

Aspirin May Prevent Prostate Cancer Recurrence  -  ‎Nov 6, 2009‎
Of the total, 196 were taking aspirin, 58 were taking Coumadin, and 24 were on Plavix. The other men weren't taking any anti-clotting medication. ... WebMD

Experts say Astra drug's U.S. miss likely a fluke  -  ‎Nov 3, 2009‎
N) $9 billion-a-year seller Plavix -- is one of AstraZeneca's biggest new drug hopes. It showed impressive overall superiority to Plavix in an 18000-patient ... Reuters

Medco Study to Gauge Whether PGx-Based Plavix Dosing is as Effective as Higher ...  -  ‎Oct 21, 2009‎
Medco's study will examine whether the 70 to 75 percent of patients who are "extensive metabolizers" of Plavix will have "comparable outcomes" with patients ... GenomeWeb Daily News

Medco Launches Plavix(R), Effient(R) Comparative Effectiveness Study Examining ...  -  ‎Oct 20, 2009‎
Plavix is going generic in 2011 and if found to be equally effective as Effient for patients who have a normally functioning version of the CYP2C19 gene, ... Reuters

How Safe Are Popular Reflux Drugs?  -  ‎Nov 4, 2009‎
Of the various health problems being linked to PPIs, one of the most concerning involves its interaction with the blood thinner clopidogrel (Plavix). ... U.S. News & World Report

Generic Name: Clopidogrel, Iscover, Clopilet, Ceruvin  -  ‎Nov 11, 2009‎
Plavix (generic name: Clopidogrel; brand names: Iscover / Clopilet / Ceruvin) is a prescription medication that belongs to a group of medicines called ... Pattaya Daily News

Verilogue Study: Does Higher DTC Spend Result in Positive Patient-Physician ...  -  ‎Nov 9, 2009‎
...(BUSINESS WIRE)--With Plavix's gurney on the golf course, Cialis' twin bath tubs and Ambien's rooster in the office, many drug commercials make for great ... Business Wire (press release)

Ahead of Pending Studies on PGx-Based Plavix Administration, Is Quest/Scripps ...  -  ‎Oct 28, 2009‎
Earlier this month, Quest announced the launch of a CYP2C19 testing service for stent procedure patients before receiving Plavix (clopidogrel) at Scripps ... GenomeWeb Daily News

Bristol-Myers, Armed With More Cash, Ready To Make Deals  -  ‎Nov 12, 2009‎
...and preparing for the loss of US market exclusivity on current top-selling drugs--including the anti-clotting pill Plavix--over the next few years. ... Wall Street Journal

Gene test guides care  -  ‎Oct 31, 2009‎
A new genetic test identifies people who likely won't benefit from taking Plavix, a common anti-clotting drug, after having a stent placed in ... San Diego Union Tribune

Executive Health Care Update  -  ‎Nov 6, 2009‎
In coronary stent procedures, of which about 1.2 million are performed annually, the standard protocol includes prescribing the anti-clotting drug, Plavix ... San Diego Metropolitan

Sanofi-aventis Delivers a Solid Performance in Third Quarter 2009  -  ‎Oct 30, 2009‎
In Europe, the product is facing competition from generics using clopidogrel with a different salt from that used by Plavix® (clopidogrel hydrogen sulphate) ... Reuters

Medco Health (MHS) Plans Head-to-Head Study of Plavix and Effient  -  ‎Oct 20, 2009‎
Medco Health Solutions, Inc. (NYSE: MHS) plans to conduct a head-to-head study of Plavix and Effient that measures how the effectiveness of these drugs in ... StreetInsider.com (subscription)

Quest Diagnostics Inc., Q3 2009 (Qtr End 09/30/09) Earnings Call Transcript  -  ‎Oct 20, 2009‎
This test helps physicians predict response to the blood thinner, Plavix. More of the roughly 1 million patients who undergo stent procedures each year are ... Seeking Alpha (blog)

Of One-Time Gains and Pipelines  -  ‎Oct 30, 2009‎
Brilinta fared better than sanofi-aventis' (NYSE: SNY) and Bristol-Myers' Plavix in a clinical trial, but that's not a guarantee of success; ... Motley Fool

Sanofi Taps Biotech Firm to Help Pipeline  -  ‎Nov 11, 2009‎
Sanofi recently started facing generic competition in some markets for its big-selling anti-clotting drug Plavix and its cancer drug Eloxatin. New York Times

Health Plans Adopt Prior-Authorization Rules for Genetic Tests, May Use Tests ...  -  ‎Nov 4, 2009‎
Plavix, the third-largest-selling drug in the US with $4.9 billion in 2008 sales, likely will lose its patent in 2011. The study will investigate whether ... Atlantic Information Services, Inc.

In DTC TV, longer doesn't have to mean less memorable, says Nielsen  -  ‎Nov 5, 2009‎
Rounding out the top five were spots for Wyeth's Pristiq (:75), Bristol- Myers Squibb/Sanofi-Aventis' Plavix (:60 and :75), and BMS's Orencia (:75). ... Medical Marketing and Media

J&J restructuring claims up to 8000 jobs; Rigel pushes failed drug into Phase ...  -  ‎Nov 3, 2009‎
Report > The Plavix case stops here. That's what the US Supreme Court has decided, refusing to consider a last-ditch patent challenge from Canadian generics ... FierceBiotech

Medco trial to explore genetic impact on Plavix versus Effient  -  ‎Oct 22, 2009‎
Plavix, the third biggest-selling medicine in the US market (2008 sales: US$4.9 billion) is facing generic competition in late 2011 when its patent expires. ... Pharma Times

Bristol's dance card  -  ‎Nov 6, 2009‎
At Bristol-Myers Squibb Co., the race is on to replace the pharmaceutical giant's biggest cash cow, the $6 billion-a-year moneymaker Plavix, ... The Daily Deal

French drug maker says it's eager to work with Boston-area companies  -  ‎Nov 10, 2009‎
But with US patents expiring on some of its best-selling traditional drugs, such as the heart pill Plavix, it has been eager to expand into the more complex ... Boston Globe

Sanofi-Aventis raised forecast on swine flu vaccines  -  ‎Oct 30, 2009‎
The 49-year-old CEO is looking outside Sanofi's own labs for products to sustain sales growth as older drugs like Plavix and Eloxatin face generic ... The FINANCIAL

There Will Be Blood (Plasma)  -  ‎Nov 11, 2009‎
Talecris' products don't carry the sales and profit power of Lipitor from Pfizer (NYSE: PFE), or Plavix from Bristol-Myers Squibb (NYSE: BMY) and ... Motley Fool

Quest Diagnostics to build $16 million medical lab  -  ‎Oct 27, 2009‎
More recently, the company developed a saliva test to measure the effectiveness of the blood thinner Plavix. "There are a million people who get the stent,� ... NewsOK.com

Medco Health Solutions, Inc., Q3 2009 Earnings Call Transcript  -  ‎Nov 3, 2009‎
This is evidenced by our published Plavix PPI study covering 17000 patients, our recently presented tamoxifen and 2D6 enzyme inhibitor study at ASCO, ... Seeking Alpha (blog)

FDA Top Officials Discuss Ongoing Efforts to Bring Agency Into Genomics Era  -  ‎Nov 11, 2009‎
To illustrate this challenge, Zineh cited the controversy around whether genetic testing for the blood thinner Plavix should be broadly marketed, ... GenomeWeb Daily News

Drug safety and your DNA  -  ‎Oct 30, 2009‎
There are three particular drugs where genetic testing might help people use them more appropriately: The anti-clotting drug, clopidogrel, or Plavix, ... Common Ground.ca

I Don't Need No Massive Merger  -  ‎Oct 23, 2009‎
It's facing a major loss of revenue when Plavix, which it sells with sanofi-aventis (NYSE: SNY), faces generic competition in the US in 2012 ... Motley Fool

Weekly Roundup  -  ‎Nov 13, 2009‎
But BMY also has a solid, young pipeline of drugs in oncology and immunology that offers promising growth and a partial offset to its Plavix patent exposure ... TheStreet.com (subscription)

Chocolate addict  -  ‎Oct 22, 2009‎
By Emiliya Mychasuk Cadbury finance director Andrew Bonfield has made the leap from discussing arthritis drugs and Plavix to cocoa and sugar-free gum in ... Financial Times

Global Cardiovascular Drugs Market By Bharatbook.com  -  ‎Nov 5, 2009‎
The years 2011 to 2015 will mark a period of high volatility in the cardiovascular market as key products - including blockbusters Plavix and Lovenox - face ... PRMinds (press release)

Eli Lilly/Daiichi Sankyo's Efient gets restricted access to NHS  -  ‎Oct 28, 2009‎
And while the companies have claimed that Efient is more effective than its rival Plavix on the back of data from the TRITON-TIMI 38 trial - which showed a ... Pharma Times

Bristol-Myers Squibb Achieves Strong Sales, Earnings Performance in Third Quarter  -  ‎Oct 22, 2009‎
Sales growth in the third quarter was led by continued sales increases for PLAVIX (+8%) and strong global sales growth for ABILIFY (+16%). ... Reuters

B-MS posts strong sales for most of its drugs  -  ‎Oct 23, 2009‎
Bristol-Myers Squibb's third-quarter financials have revealed continued strong sales of the bloodthinner Plavix and the antipsychotic Abilify and the firm ... Pharma Times

The Hospitalist Era (and Errors)  -  ‎Oct 22, 2009‎
...of mine was discharged on a combination of two medications that never should be mixed together because of the high risk of bleeding (Motrin and Plavix). ... The Sacramento Press

Teva broadens suit against Copaxone copycats; Enzon sells marketed meds for $300M;  -  ‎Nov 10, 2009‎
Report > The popular blood-thinner Plavix prevents heart attacks and strokes in both women and men, but the benefits differ slightly by gender, ... FiercePharma

Lilly Swings To 3Q Profit From Year-Ago Charges  -  ‎Oct 21, 2009‎
Effient competes with blockbuster blood thinner Plavix from Bristol-Myers Squibb Co. (BMY) and Sanofi-Aventis SA (SNY). Lilly boosted its 2009 earnings ... Wall Street Journal

Smart Rx: Drugs that work and won't break the bank  -  ‎Nov 4, 2009‎
Over the next five years products worth $137 billion are expected to go generic, including bloodthinner Plavix and cholesterol medicine Lipitor. ... The Associated Press

Forecast Insight - Antithrombotics - Market growth dependent on new agents ...  -  ‎Oct 26, 2009‎
The growth can be mainly attributed to the increased uptake of Plavix (clopidogrel) and Lovenox (enoxaparin) in all of the seven major markets. ... PR-Inside.com (Pressemitteilung)

Aspirin effect fuels concern over AstraZeneca drug  -  ‎Oct 29, 2009‎
..."Clearly, Brilinta does have benefits over aspirin plus Plavix, but there are question-marks in the US as to what sort of traction they will get," said ... Reuters India

Plavix Pain  -  Aug 8, 2006
The news that a generic company will start selling a copycat of the blockbuster blood-thinner Plavix is likely to send shock waves through the entire drug ... Forbes

Mixed results for would-be rival to Plavix  -  Nov 5, 2007
By Alex Berenson. ORLANDO, Florida — An experimental anti-clotting drug from Eli Lilly and Daiichi Sankyo significantly reduced heart attacks in patients ... New York Times

Bristol-Myers Shares Jump After Generic Plavix Ban  -  Sep 1, 2006
By Lisa Rapaport and Carey Sargent. Sept. 1 (Bloomberg) -- Shares of Bristol-Myers Squibb Co. rose 5.5 percent after a court ordered Canada's Apotex Inc. to ... Bloomberg

Study Raises Questions on Plavix Safety  -  Jan 20, 2005
By GARDINER HARRIS. Patients taking Plavix, a popular and expensive antistroke drug, experience more than 12 times as many ulcers as patients who take ... New York Times

Plavix: Judge blocks sale of generic version  -  Jun 19, 2007
NEW YORK (AP) — A federal judge Tuesday permanently blocked a Canadian maker of a cheap generic version of blood thinner Plavix from marketing the drug, ... USA Today

Study: Aspirin, Plavix Combo Harmful  -  Mar 13, 2006
ATLANTA — Some people taking the blood thinner Plavix on top of aspirin to try to prevent heart attacks, as many doctors recommend, now have good reason to ... FOXNews

Study: Concerns on Mixing Plavix, Heartburn Drugs  -  Nov 11, 2008
By MATTHEW PERRONE and MARLEY SEAMAN AP Business Writers. AP. Stent patients who take the blood thinner Plavix along with certain heartburn drugs may face a ... ABC News

Schweizerhall says near generic Plavix launch  -  May 9, 2008
By Sarah Turner, MarketWatch. LONDON (MarketWatch) -- Swiss generics firm Schweizerhall Holdings said Friday that it's on the verge of launching a generic ... MarketWatch

Bristol profit jumps as Plavix continues rebound  -  Oct 25, 2007
By Ransdell Pierson. NEW YORK (Reuters) - Bristol-Myers Squibb Co (BMY.N) on Thursday said third-quarter earnings more than doubled after a strong rebound ... Reuters

FDA approves expanded use for blood-thinner Plavix  -  Aug 17, 2006
WASHINGTON (AP) — The popular blood-thinning drug Plavix received expanded federal approval Thursday to prevent the sudden blockage of arteries that can ... USA Today

Bristol profit beats forecasts, helped by Plavix  -  Jul 24, 2008
NEW YORK (Reuters) - Bristol-Myers Squibb Co (BMY.N) on Thursday reported second-quarter earnings that beat expectations, fueled by higher sales of its ... Reuters UK

Plavix Saves Lives From Severe Heart Attacks  -  Mar 10, 2005
By Peggy Peck. Adding the blood thinner Plavix (search) to standard heart attack treatments could cut deaths from severe heart attacks by more than a third. ... FOXNews

States Reject Plavix Generic Pact  -  Jul 28, 2006
By TSC Staff. A deal between Bristol-Myers Squibb (BMY - commentary - Cramer's Take) and Sanofi-Aventis (SNY - commentary - Cramer's Take) to delay generic ... TheStreet.com - TheStreet.com (subscription)

Thai govt approves generic versions of Kaletra, Plavix  -  Jan 29, 2007
BANGKOK (XFN-ASIA) - The health ministry said it has approved generic versions of the anti-AIDS drug Kaletra and the blockbuster heart drug Plavix. ... Forbes

Stopping Plavix may carry early clotting risk  -  Feb 6, 2008
By Julie Steenhuysen. CHICAGO (Reuters) - Patients given the blood-clot preventer Plavix after a heart attack or after receiving a stent have a far higher ... Reuters

Bristol-Myers reaches settlement with DOJ on Plavix charges - …  -  May 10, 2007
By Angela Moore, MarketWatch. SAN FRANCISCO (MarketWatch) -- Bristol-Myers Squibb Co. on Thursday said it reached an agreement in principle with US ... MarketWatch

Plavix Sellers Aim to Block Generic  -  Aug 14, 2006
Sanofi-Aventis (SNY Quote) and Bristol-Myers Squibb (BMY Quote) returned to court Monday, asking a federal judge to block Canada's Apotex from shipping ... TheStreet.com - TheStreet.com (subscription)

Studies: Plavix Stems Second Attacks .  -  Mar 10, 2005
...heart attack patients save lives and prevents second heart attacks, two large International studies found . The strategy is the first big advance in heart ... St. Petersburg Times - Google News Archive

First 90 Days After Stopping Plavix Most Dangerous  -  Feb 5, 2008
By Ed Edelson. TUESDAY, Feb. 5 (HealthDay News) -- New research finds that the first three months after heart patients stop taking the clot-preventing drug ... Washington Post

Drug Makers Reach Accord in Patent Case Over Plavix  -  Mar 22, 2006
By STEPHANIE SAUL. Sanofi-Aventis and its partner Bristol-Myers Squibb said late yesterday that they had tentatively settled a patent dispute involving ... New York Times

Bristol, Sanofi face FTC probe over Plavix deal  -  Apr 3, 2007
By Peter Loftus. (Adds comments from Bristol-Myers, Sanofi-Aventis and FTC beginning in 7th paragraph; adds background throughout. Updates stock prices.) ... MarketWatch

Sanofi-Aventis' Plavix drug could slash deaths from heart attack -...  -  Nov 3, 2005
PARIS (AFX) - Clopidogrel, a new drug designed to prevent blood clots, can significantly reduce the risk of death by heart attack when used alongside ... Forbes

Genetic variation makes Plavix less effective-study  -  Dec 23, 2008
LONDON, Dec 23 (Reuters) - Young heart attack survivors with a common genetic variation were more likely to die or have a serious heart problem while taking ... Reuters India

Bristol Counts on Plavix Resurgence  -  Apr 25, 2007
By Robert Steyer 04/25/07 - 02:03 PM EDT. When Bristol-Myers Squibb(BMY Quote) issues first-quarter results Thursday morning, the pharmaceutical company ... TheStreet.com - TheStreet.com (subscription)

Filing deadline in Sanofi-Aventis' Plavix patent trial put back to...  -  May 10, 2005
PARIS (AFX) - Sanofi-Aventis SA said the filing date for a patent infringement suit over its Plavix drug with generic producers Apotex and Dr Reddy's ... Forbes

German court backs immediate generic Plavix  -  Jul 29, 2008
By Ben Hirschler. LONDON (Reuters) - French drugmaker Sanofi-Aventis (SASY.PA) and its US partner Bristol-Myers Squibb Co (BMY. ... Reuters UK

Bristol-Myers Chief Fired After Bungling Plavix Deal  -  Sep 12, 2006
By Lisa Rapaport and David Voreacos. Sept. 12 (Bloomberg) -- Bristol-Myers Squibb Co. Chief Executive Officer Peter Dolan was fired after bungling an ... Bloomberg

Staying On Plavix May Cut Stent Risk  -  Dec 5, 2006
By none. Learn more about different types of heart disease, explore different treatments and assess your own risk. (WebMD) The blood thinner Plavix may ... CBS News

Lawyers spar as Plavix patent trial begins  -  Jan 22, 2007
By Martha Graybow. NEW YORK, Jan 22 (Reuters) - A lawyer for Sanofi-Aventis (SASY.PA) and Bristol-Myers Squibb Co. (BMY.N) urged a US judge to uphold the ... Reuters

Bristol-Myers Faces Plavix Risk, Decelerating Growth  -  Dec 12, 2005
Bear Stearns research analyst John Boris maintained a "peer perform" rating on Bristol-Myers Squibb (nyse: BMY - news - people ) and lowered earnings ... Forbes

Executive Charged With Lying in Plavix Case  -  Apr 23, 2008
By AP. WASHINGTON — A former executive at the drug maker, Bristol-Myers Squibb, was charged Wednesday with lying to federal authorities about a patent deal ... New York Times

Plavix plus aspirin may be a risky combination  -  Mar 14, 2006
What happened? A new study has found that adding the anti-clotting drug clopidogrel (Plavix) to a daily dose of aspirin — compared with aspirin alone — does ... CNN

Bristol-Myers Profit Rises on Plavix Sales, Tax Gain  -  Jul 28, 2005
By Nicole Ostrow. July 28 (Bloomberg) -- Bristol-Myers Squibb Co., the No. 5 US drugmaker, said second-quarter profit almost doubled to $1 billion, ... Bloomberg

Plavix sales narrow Bristol-Myers loss  -  Jan 31, 2008
By Jennifer Sterling, AP Business Writer | January 31, 2008. NEW YORK --Bristol-Myers Squibb Co. said Thursday that fourth-quarter losses narrowed on better ... Boston Globe

Thailand to import generic version of heart drug Plavix from India  -  Aug 22, 2007
BNAGKOK (Thomson Financial) - The Thai government said Wednesday it would import generic versions of popular heart disease drug Plavix from India. ... Forbes

Bristol-Myers Profit Falls as Plavix Copy Hurts Sales  -  Oct 26, 2006
By Lisa Rapaport. Oct. 26 (Bloomberg) -- Bristol-Myers Squibb Co.'s third- quarter net income fell 65 percent after cheap generic copies of its best-selling ... Bloomberg

Gene Ups Risk for Those on Blood-Thinner Plavix  -  Dec 21, 2008
MONDAY, Dec. 22 (HealthDay News) -- A gene variation can make younger heart attack patients more prone to another heart attack, death or other heart ... Forbes

Bristol Counts on Plavix Resurgence  -  Feb 27, 2007
For the just-completed quarter, Pravachol sales are expected to be a sliver of the $536 million reported in the year-ago quarter when the cholesterol drug ... TheStreet.com - TheStreet.com (subscription)

Study: Plavix before angioplasty saves lives  -  Sep 5, 2005
By Emma Ross. AP. STOCKHOLM, Sweden — Giving heart-attack patients a dose of "superaspirin" before rather than during a procedure to restore blood flow to ... Seattle Times

FDA Panel Seeks Warning That Stents May Be Unsafe  -  Dec 8, 2006
He tooke the platlet inhibiting drug Plavix for a full 2 year period until a ... Conclusion: Plavix statistically not any better than asprin alone without ... Washington Post

US FDA approves higher dose of clot drug Plavix  -  Sep 27, 2007
NEW YORK, Sept 27 (Reuters) - US regulators have approved a higher-dosage tablet form of the blockbuster blood-clot preventer Plavix that will offer ... Reuters

Court backs Bristol, Sanofi on generic Plavix  -  Dec 13, 2008
Bristol-Myers Squibb Co. and Sanofi-Aventis won an appeals court ruling Friday that will help them block generic competition to the blood thinner Plavix, ... Los Angeles Times

Patent Fight Bounces Bristol-Myers CEO  -  Sep 13, 2006
31 ruling in US District Court, the Plavix patent wasn't as vulnerable as Dolan had feared. ... That class of compounds included what would become Plavix. ... BusinessWeek

Apotex loses patent ruling over Sanofi's Plavix: Federal Court...  -  Mar 23, 2005
Sanofi-Aventis SA has won a patent case in Canada over its top-selling blood thinner Plavix, boosting its own shares and those of its US partner ... Free with registration - America's Intelligence Wire - AccessMyLibrary.com

Bristol-Myers pleads guilty in Plavix case  -  Jun 12, 2007
Drug maker Bristol-Myers Squibb Co. said Monday that it pleaded guilty to two counts of making false statements to the Federal Trade Commission regarding ... Pay-Per-View - Los Angeles Times - ProQuest Archiver

Bristol-Myers settles Plavix case with states  -  Dec 23, 2008
Last year, Bristol-Myers pleaded guilty to two federal criminal counts related to allegations that it illegally concealed a side deal with the generic ... Reuters

Plavix Disappoints in Clinical Study  -  Mar 13, 2006
By Althea Chang. ATLANTA -- A clinical study has found that adding the blockbuster anticoagulant Plavix to aspirin isn't significantly better than aspirin ... TheStreet.com - TheStreet.com (subscription)

PREVIEW-Expected Sanofi Plavix win could unleash M&A  -  Jan 18, 2007
By Caroline Jacobs. PARIS, Jan 18 (Reuters) - The odds on Sanofi-Aventis (SASY.PA) saving its patent on blockbuster Plavix from generic rivalry in the ... Reuters

Prescription For Upheaval  -  Oct 17, 2005
Cheap generic versions of Plavix would hit the market no later than 2011. If prasugrel wasn't shown to be better than Plavix, why would anyone pick it over ... BusinessWeek

Sanofi-Aventis says generic Plavix launch by Dr. Reddy 'highly...  -  Jan 17, 2008
By Jethro Mullen. PARIS (MarketWatch) -- Sanofi-Aventis said Thursday it believes it is "highly unlikely" that India's Dr. Reddy's Laboratories Ltd. will ... MarketWatch

Drug makers say generic Plavix forcing price cuts  -  Aug 22, 2006
By Bloomberg News | August 22, 2006. A witness for Bristol-Myers Squibb Co. and Sanofi-Aventis SA said the price of the blood thinner Plavix may fall as ... Boston Globe

Appeals court won't rehear Plavix patent ruling  -  Jan 19, 2007
By Peter Kaplan. WASHINGTON (Reuters) - A US appeals court on Friday refused to reconsider a ruling that bars Apotex Inc. from selling its generic version ... Reuters

Prasugrel better on stent-related clots than Plavix - study  -  Mar 30, 2008
CHICAGO Thomson Financial - A cocktail of new anti-blood clot drug Prasugrel and aspirin reduces the risk of stent-related clots more than the standard ... Forbes

Plavix Facing Generic Challenge  -  Jan 24, 2006
By Robert Steyer. The Food and Drug Administration on Tuesday said a Canadian company could sell a generic version of the anticoagulant Plavix, ... TheStreet.com - TheStreet.com (subscription)

Sanofi/Bristol-Myers Plavix accord with Apotex rejected by US...  -  Jul 30, 2006
PARIS (AFX) - Sanofi-Aventis and Bristol-Myers Squibb Co said their out-of-court settlement allowing Canada's Apotex to produce their blood-thinning ... Forbes

Bristol pleads guilty in Plavix case  -  Jun 11, 2007
By Ransdell Pierson. NEW YORK (Reuters) - Bristol-Myers Squibb Co. (BMY.N) on Monday said it had pleaded guilty to two federal criminal counts related to ... Reuters

Sanofi-Aventis ends key part of Plavix study for atrial fibrillation...  -  Sep 7, 2005
PARIS (AFX) - Sanofi-Aventis SA said investigators have decided to end a key portion of a Phase III study evaluating the use of Plavix with aspirin to treat ... Forbes

Novartis to sell generic Plavix for 25 pct less  -  Aug 6, 2008
ZURICH, Aug 6 (Reuters) - Novartis AG (NOVN.VX: Quote, Profile, Research) will sell a generic version of Sanofi-Aventis SA's (SASY. ... Reuters India

Sanofi-Aventis expects to avoid prosecution in Plavix case in US  -  Jun 1, 2007
PARIS (Thomson Financial) - Sanofi-Aventis does not expect to be prosecuted in a US case relating to the Plavix drug, according to comments by the company's ... Forbes

US Inquiry Into Bid to Suppress a Generic Plavix  -  Apr 4, 2007
By BLOOMBERG NEWS. Bristol-Myers Squibb and Sanofi-Aventis have received demands from United States antitrust regulators for documents related to an ... New York Times

New Settlement on Plavix Patent  -  Jun 26, 2006
By BLOOMBERG NEWS. Two drug companies, the Bristol-Myers Squibb Company and Sanofi- Aventis, agreed yesterday to shorten the patent protection time on the ... New York Times

Higher Dose of Clot-Buster Is Better Before Artery Procedure  -  May 11, 2007
..."Although Plavix is powerful stuff, the meta-analysis did not find an ... Most had either 300 milligrams or 600 milligrams of Plavix before the procedure. ... Washington Post

Court Upholds Preliminary Plavix Injunction  -  Sep 21, 2006
By Robert Steyer. A federal appeals court on Thursday ruled that Canadian company Apotex can't resume shipping generic versions of the anticoagulant Plavix ... TheStreet.com - TheStreet.com (subscription)

Fake versions of Sanofi's Plavix drug found in UK  -  May 29, 2007
LONDON (Reuters) - Counterfeit batches of Sanofi-Aventis SA's best-selling blood-thinning drug Plavix have been discovered in the British supply chain, ... Reuters

Fast-growing Plavix is top earner for Bristol, Sanofi - Jan. 18, 2006  -  Jan 18, 2006
By Aaron Smith, CNNMoney.com staff writer. NEW YORK (CNNMoney.com) - Bristol-Myers Squibb and Sanofi-Aventis got some good news from the FDA that could add ... CNNMoney.com

Sanofi sees Plavix generic stock ending in Q2  -  Feb 13, 2007
PARIS, Feb 13 (Reuters) - French drugmaker Sanofi-Aventis (SASY.PA) expects the stock of a generic to its bloodthinner Plavix, which temporarily hit the US ... Reuters

Prasugrel seen better for diabetes patients than Plavix  -  Aug 31, 2008
MUNICH, Aug 31 (Reuters) - Eli Lilly (LLY.N) and Daiichi Sankyo's (4568.T) new blood-thinning drug prasugrel appears better for diabetes patients than ... Reuters UK

Genetic variation makes Plavix less effective-study  -  Dec 22, 2008
LONDON, Dec 23 (Reuters) - Young heart attack survivors with a common genetic variation were more likely to die or have a serious heart problem while taking ... Reuters

… Commission Expands Indication for PLAVIX(R) (clopidogrel bisulfate)...  -  Sep 7, 2006
Sanofi-aventis (EURONEXT: SAN and NYSE: SNY) and Bristol-Myers Squibb Company (NYSE: BMY) announced today that the European Commission has granted a new ... ots.at

REFILE-Schweizerhall says generic Plavix approved in Germany  -  May 28, 2008
ZURICH, May 28 (Reuters) - Switzerland's Schweizerhall SWHN.S said on Wednesday its blood-thinning drug clopidogrel, a copy-cat generic version of Plavix ... Reuters

… - LOADING DOSE TABLET FOR PLAVIX RECEIVES POSITIVE OPINION.  -  Mar 5, 2008
Sanofi-aventis (EURONEXT: SAN and NYSE: SNY) and Bristol-Myers Squibb Company (NYSE: BMY) announced today that the Committee for Medicinal Products for ... Free with registration - AsiaPulse News - AccessMyLibrary.com

Sanofi sees US generic Plavix exhausted in Q2  -  May 3, 2007
LONDON, May 3 (Reuters) - French drugmaker Sanofi-Aventis SA (SASY.PA) expects cheap generic stocks of its top-selling blood thinner Plavix to run out in ... Reuters

Analyst Slashes Bristol Estimates On Plavix Concerns  -  Aug 11, 2006
Merrill Lynch cut earnings-per-share estimates on Bristol-Myers Squibb as continued concerns regarding generic competition for Plavix sent shares down to ... Forbes

Sanofi, Bristol-Myers Shares Fall on Plavix Threat  -  Aug 4, 2006
By Angela Cullen and Michelle Fay Cortez. Aug. 4 (Bloomberg) -- Shares of Sanofi-Aventis SA and partner Bristol-Myers Squibb Co. slumped on speculation that ... Bloomberg

Sanofi-Aventis Still Faces Plavix Patent Uncertainty  -  Aug 31, 2005
Standard & Poor's Equity Research reiterated a "hold" rating on Sanofi-Aventis, saying the French pharmaceutical company still faces patent uncertainty. ... Forbes

US says Bristol to pay $1 mln fine in Plavix case  -  May 30, 2007
WASHINGTON, May 30 (Reuters) - Bristol-Myers Squibb (BMY.N) has agreed to pay a $1 million criminal fine for lying to the federal government about a patent ... Reuters

Bristol-Myers Net Rises 34% Percent on Plavix Sales  -  Apr 27, 2006
By Rob Waters and Juliann Walsh. April 27 (Bloomberg) -- Bristol-Myers Squibb Co. said first-quarter earnings rose 34 percent as increased demand for the ... Bloomberg

Euroshares open flat as inflation concerns weigh; Sanofi gains on...  -  Aug 15, 2006
But Sanofi-Aventis bucked the trend in Europe after filing for an injunction against generic Plavix in the US. Trading was thin, with public holidays in ... Forbes

Generic Plavix Hurts Bristol-Myers  -  Aug 8, 2006
Stocks traded modestly higher at midday, boosted by buyout news from Aramark and Aleris and a continued flurry of earnings reports. ... Forbes

Bristol-Myers Squibb's Plavix In Q2 Spotlight  -  Jul 25, 2006
Bear Stearns maintained a "peer perform" rating on Bristol-Myers Squibb ahead of the pharmaceutical firm's second-quarter earnings report. ... Forbes

Lilly's Scary Silence  -  Oct 26, 2007
One reason: Plavix must be converted into another chemical inside the body. ... If prasugrel works in people who don't respond to Plavix but is otherwise no ... Forbes

Judge stops sales of generic Plavix  -  Aug 31, 2006
NEW YORK (AP) -- For three weeks, patients who use Plavix have been able to buy a cheaper generic version. But those sales are coming to an abrupt halt, ... WKYC-TV

Bristol blames Canadian drugmaker for Plavix sales plunge - Jan. 25, ...  -  Jan 25, 2007
Interim CEO blames generic competition against Plavix for earnings disappointment, says HIV drug will drive future sales. By Aaron Smith, CNNMoney.com staff ... CNNMoney.com

Lilly, Daiichi Sankyo Say Drug Outperforms Plavix  -  Oct 23, 2006
By Catherine Larkin. Oct. 23 (Bloomberg) -- Eli Lilly & Co. and Daiichi Sankyo Co. said their experimental drug prasugrel prevented blood clots better than ... Bloomberg

Sanofi-Aventis 3Q Hit By Plavix Loss  -  Oct 31, 2006
By Elena Berton. LONDON -(Dow Jones)- Sanofi-Aventis SA (SNY) Tuesday reported declining third-quarter earnings as a result of the loss of top-selling blood ... CNNMoney.com

Bristol, Sanofi win Plavix ruling  -  Dec 9, 2006
The injunction didn't require Apotex to recall the product it had already sold, so both Bristol-Myers and Sanofi-Aventis had to lower their earnings ... Pay-Per-View - Los Angeles Times - ProQuest Archiver

Sanofi-Aventis says UK's Aircoat has abandoned effort to revoke Plavix...  -  Aug 5, 2005
The company had launched its effort to produce a generic version of Plavix in January. Sanofi-Aventis is also currently defending Plavix in the US, ... Forbes

Description: Report suggests combining Plavix with certain heart...  -  Nov 30, 2008
..." About Plavix and do you take that it has to do is a very popular you know and there's a new report that you want to cut the doctor about that when you ... FOXNews

Medco's Plavix Puzzle | Health Care | Financial Articles & Investing...  -  Sep 1, 2006
Last month's happy surprise in the pharmacy sector -- the launch of generic Plavix -- has turned into a question mark. A federal judge this week blocked ... TheStreet.com - TheStreet.com (subscription)

Is Sanofi-Aventis After Bristol-Myers?  -  Jan 29, 2007
The two companies have long-standing marketing alliances for Plavix and hypertension drug ... Considering how much is at stake—Plavix is the world's fourth ... BusinessWeek

Bristol-Myers, Sanofi Trial Over Plavix Patent Ends in New York  -  Feb 15, 2007
By Lindsay Fortado and Susan Decker. Feb. 15 (Bloomberg) -- Bristol-Myers Squibb Co. and Sanofi- Aventis SA's bid to protect the blood-thinning drug Plavix ... Bloomberg

Medco Profit Falls on Prior Gain From Generic Plavix  -  Apr 29, 2008
By Shannon Pettypiece. April 29 (Bloomberg) -- Medco Health Solutions Inc., the biggest US manager of drug benefits, said profit fell and the company ... Bloomberg

Bristol-Myers Drops on Dashed Deal Hopes  -  Feb 12, 2007
..."We think no deal is likely until BMY's Plavix patent litigation is resolved," ... The two companies have long-standing marketing alliances for Plavix and ... BusinessWeek

Plavix sales hike profit for Sanofi-Aventis  -  Feb 12, 2008
AP. PARIS–Sanofi-Aventis said Tuesday net profit in the fourth quarter rose 31 per cent, helped by sales of blood-thinner Plavix in the United States and ... Toronto Star

FDA says heartburn drugs can interfere with Plavix  -  Jul 28, 2006
By Matthew Perrone. AP Business Writer / November 17, 2009. WASHINGTON—Federal health officials said Tuesday a popular variety of heartburn medications can ... Boston Globe

Study Upholds Stopping Plavix Use Before Surgery  -  Nov 10, 2008
By Ed Edelson. MONDAY, Nov. 10 (HealthDay News) -- Someone who has taken the clot-preventing drug Plavix less than five days before having bypass surgery ... Washington Post

Plavix boosts Bristol-Myers  -  Jul 26, 2007
Damian Troise AP. NEW YORK – Bristol-Myers Squibb Co. said Thursday its second-quarter profit rose nearly 6 per cent, with the blood-thinner Plavix and the ... Toronto Star

Bristol's Plavix May Be Used for Years, Doctors Say  -  Nov 15, 2006
By Michelle Fay Cortez. Nov. 15 (Bloomberg) -- Heart patients who get drug-coated stents to prop open arteries are being told for the first time they may ... Bloomberg

Federal regulators delay Eli Lilly blood thinner  -  Sep 26, 2008
Prasugrel would compete against the blockbuster blood thinner Plavix, which loses patent ... Plavix, made by Sanofi-Aventis SA and Bristol-Myers Squibb Co., ... USA Today

A New Hope For Schering-Plough  -  Mar 25, 2007
But that drug works in much the same way as Plavix. Both Plavix and prasugrel come with the same side effect: By thinning the blood to prevent clots, ... Forbes

Brand Names/Synonyms:
Plavix is also known by the following brand names and/or synonymsCLOPIDOGREL SULFATE; Clopidogrel; Clopidogrel [Ban:Inn]; Plavix

Drug Category:
Plavix is categorized under the following by the FDA: Antiplatelet Agents; Platelet Aggregation Inhibitors; Fibrinolytic Agents; ATC:B01AC04

Dosage Forms:
round, biconvex, film- coated tablet

Absorption:
at least 50%

Interactions:
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Chemical IUPAC Name:
methyl2-(2-chlorophenyl)-2-(7-thia-3-azabicyclo[4.3.0]nona-8,10-dien-3-yl)ethanoate





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