Prazosin

This page contains recent news articles, when available, and an overview of Prazosin but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Prazosin (when available)

Pharmacology and use:
Prazosin is an alpha-adrenergic blocking agent used to treat hypertension and benign prostatic hyperplasia. Accordingly, Prazosin is a selective inhibitor of the alpha1 subtype of alpha adrenergic receptors. In the human prostate, Prazosin antagonizes phenylephrine (alpha1 agonist)-induced contractions, in vitro, and binds with high affinity to the alpha1c adrenoceptor, which is thought to be the predominant functional type in the prostate. Studies in normal human subjects have shown that Prazosin competitively antagonized the pressor effects of phenylephrine (an alpha1 agonist) and the systolic pressor effect of norepinephrine. The antihypertensive effect of Prazosin results from a decrease in systemic vascular resistance and the parent compound Prazosin is primarily responsible for the antihypertensive activity. For treatment of hypertension and chronic heart failure.

Mechanism Of Action:
Prazosin acts by inhibiting the postsynaptic alpha(1)-adrenoceptors on vascular smooth muscle. This inhibits the vasoconstrictor effect of circulating and locally released catecholamines (epinephrine and norepinephrine), resulting in peripheral vasodilation.

News Articles on Prazosin

Factoring BP into exercise equation  -  ‎Nov 5, 2009‎
...have tended to fall from favour in the last decade or so due to perceived problems with tachyphylaxis, which was a particular problem with prazosin. ... New Zealand Doctor Online

Alpha adrenergic modulation on effects of norepinephrine ...  -  ‎Aug 14, 2009‎
Alpha-1 adrenergic receptor antagonist prazosin and alpha-2 adrenergic receptor antagonist RX821002 were used to clarify the RBX effect. 7thSpace Interactive (press release)

Sigarayla savaşı kazanacağız  -  ‎Aug 17, 2009‎
Tansiyon düşürücü ilaçlardan bazılarının (reserpin, beta blokerler, prazosin, klanidin), çeşitli mide ilaçlarının (özellikle simetidin ihtiva edenler), Hürriyet

LEVITRA ONLINE . BUY LEVITRA. PURCHASE LEVITRA ONLINE  -  ‎Jul 12, 2009‎
It is also important that you don't take Levitra if you are taking any alpha-blocker medicine such as terazosin or prazosin. You should also consult your Cleveland Indy Media

FDA Safety Changes: Minipress, Letairis, Coly-Mycin M Parenteral  -  ‎Jun 24, 2009‎
On April 6, the FDA approved safety labeling changes for prazosin HCl (Minipress capsules; Pfizer, Inc) to warn of the risk for intraoperative floppy iris Medscape

Viagra rivals add hours of hope for men - $1.15 per PILL  -  ‎Jun 30, 2009‎
These drugs would include bosentan, blood thinners, cimetidine, certain antibiotics, doxazosin, prazosin, Terazosin, HIV medicines such as amprenavir Toute la Poésie

This Month in Archives of General Psychiatry  -  ‎Apr 6, 2009‎
Harpaz-Rotem and Rosenheck (SEE ARTICLE) used geographic surveillance data to track the diffusion of a novel treatment, prazosin, for posttraumatic stress Archives of General Psychiatry

第�??一章肾上腺素�?�体阻断�?�  -  ‎Apr 12, 2009‎
...哌唑嗪（prazosin）选择性地阻断α1�?�体而对α2�?�体的阻断�?少，因此�?促进去甲肾上腺素的释放，加快心率的副作用较轻，�?��?��?�有效。近年�?��?�?少哌唑嗪的�?生物，�?为一青年人

Men’s Health Matters: Benign Diseases of the Prostate Gland  -  Jan 31, 2009
Should symptoms deteriorate, medication in the form of 5? reductase inhibitors (finasteride, duasteride) or? blockers (prazosin, terazosin) can be helpful. The Island (subscription),

High blood pressure  -  Jan 21, 2009
Alpha-blockers: doxazosin (Cardura), prazosin (Hypovase) and terazosin (Hytrin). Angiotensin II receptor blockers (ARBs): candesartan (Amias), guardian.co.uk,

What treatments work for Raynaud's disease?  -  Jan 21, 2009
...[15] Prazosin (Hypovase): One small study found that this drug helped reduce the number of attacks suffered by people with Raynaud's. guardian.co.uk,

What's the evidence for alpha-blockers?  -  Jan 21, 2009
Buzelin JM, Herbert M, Blondin P, et al Alpha-blocking treatment with alfuzosin in symptomatic benign prostatic hyperplasia: comparative study with prazosin guardian.co.uk,

An Expert Interview With Doug Zatzick, MD  -  Nov 11, 2008
There have been some studies showing that prazosin may be useful for nightmares/sleep when given with an SSRI and it is not habit-forming, but it may cause Medscape (registration)

Novel Treatment Approaches for Refractory Anxiety Disorders  -  Nov 18, 2008
Prazosin, a centrally active 1 -adrenergic antagonist, showed evidence of efficacy for the treatment of nightmares, sleep disturbance, and overall PTSD Focus (subscription)

男人�?�?的梦魇患�?列腺疾病：中年11％；�?年92%  -  Nov 13, 2008
...过去，�?列腺肿胀的内科治疗方案和�?�物主�?包括�?低尿管水压�?阿尔法�?�体阻滞剂（Alpha blockers）�?�哌唑嗪（Prazosin �?�洋商报,

For returning veterans, sleep is the latest enemy  -  Sep 13, 2008
Some doctors have had some good results prescribing Ambien, which is less addictive, and the hypertension drug prazosin, which can reduce nightmares. Nashua Telegraph,

Understanding Prostate Disease  -  Aug 30, 2008
Should symptoms deteriorate, medication in the form of 5? reductase inhibitors (finasteride, duasteride) or ? blockers (prazosin, terazosin) can be helpful. The Island (subscription),

Older People in Danger from Common Drugs  -  Aug 28, 2008
Doxazosin (Cardura), prazosin (Vasoflex), and Terazosin (Hytrin) can cause incontinence as well as dangerously low blood pressure. NewsMax.com,

鉅亨看世界�?失眠的�?波  -  Sep 10, 2008
...復原計畫的醫療主任Dr. Tasha Souter表示，有些醫生開出Ambien處方用藥，效果較好，病患上癮的情形�?低，�?�外�?低情緒�?�度緊張的prazosin 鉅亨網,

Story, not found in the Citizen:  -  Sep 3, 2008
The medication would mix with other VA-prescribed drugs: Prozac for depression, Prazosin for nightmares and Bupropion to help the sergeant sleep. The Citizen.com,

Sleep the latest enemy for Iraq War veterans  -  10 Aug 2008
Some doctors have had some good results prescribing Ambien, which is less addictive, and the hypertension drug prazosin, which can reduce nightmares. Monterey County Herald,

Home from Iraq, sleep is now the enemy for veterans  -  Aug 4, 2008
Some doctors have had some good results prescribing Ambien, which is less addictive, and the hypertension drug prazosin, which can reduce nightmares. Los Angeles Times,

علاج تضخم البروستاتا  -  Aug 5, 2008
مثبطات أل�?ا: (terazosin (Hytrin), doxazosin (Cardura), (Flomax), prazosin (Uroxatral �?مثبطات أل�?ا تحسن الأعراض ولكنها لا تقلل حجم التضخم. القبس,

Bizarre Behavior in a Patient Treated With Prazosin for PTSD  -  02 Jun 2008
To The Editor: Prazosin is an alpha 1 antagonist that is often used to treat hypertension and benign prostatic hypertrophy. However, prazosin has also been Am J Psychiatry (subscription)

Pitt doctors to help veterans rest easy  -  May 24, 2008
The medication Prazosin, which reduces nightmares and insomnia, is thought to work by reducing a derivative of adrenalin, and thus tension, Pittsburgh Post Gazette,

The Symptoms of Pheochromocytoma  -  Feb 20, 2008
Examples of Alpha-blockers include phenoxybenzamine, doxazosin, prazosin and terozosin. Beta-blockers make the heart beat slower and with less force. Informative Post,

Brand Names/Synonyms:
Prazosin is also known by the following brand names and/or synonyms:
CHEMBANK349; Furazosin; HSDB 3298; Lentopres; Minipress; Minipress Xl; Prazosin; Prazosin Base; Prazosin Hcl; Prazosin Hydrochloride; Prazosina [Inn-Spanish]; Prazosine [Inn-French]; Prazosinum [Inn-Latin]; Vasoflex

Drug Category:
Prazosin is categorized under the following by the FDA: Antihypertensive Agents; Alpha-adrenergic Blocking Agents; ATC:C02CA01

Dosage Forms:
TABLET

Absorption:
Well-absorbed from gastrointestinal tract; bioavailability is variable (50 to 85%).

Interactions:
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Chemical IUPAC Name:
[4-(4-amino-6,7-dimethoxy-quinazolin-2-yl)piperazin-1-yl]-(2-furyl)methanone

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