Prednisolone

This page contains recent news articles, when available, and an overview of Prednisolone but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Prednisolone
(when available)

Pharmacology and use:
Prednisolone is a synthetic glucocorticoid used as antiinflammatory or immunosuppressive agent. Prednisolone is indicated in the treatment of various conditions, including congenital adrenal hyperplasia, psoriatic arthritis, systemic lupus erythematosus, bullous dermatitis herpetiformis, seasonal or perennial allergic rhinitis, allergic corneal marginal ulcers, symptomatic sarcoidosis, idiopathic thrombocytopenic purpura in adults, leukemias and lymphomas in adults, and ulcerative colitis. Glucocorticoids are adrenocortical steroids and cause profound and varied metabolic effects. In addition, they modify the body's immune responses to diverse stimuli. For the treatment of primary or secondary adrenocortical insufficiency, such as congenital adrenal hyperplasia, thyroiditis. Also used to treat psoriatic arthritis, rheumatoid arthritis, ankylosing spondylitis, bursitis, acute gouty arthritis and epicondylitis. Also indicated for treatment of systemic lupus erythematosus, pemphigus and acute rhematic carditis. Can be used in the treatment of leukemias, lymphomas, thrombocytopenia purpura and autoimmune hemolytic anemia. Can be used to treat celiac disease, insulin resistance, ulcerative colitis and liver disorders.

Mechanism Of Action:
Glucocorticoids such as Prednisolone can inhibit leukocyte infiltration at the site of inflammation, interfere with mediators of inflammatory response, and suppress humoral immune responses. The antiinflammatory actions of glucocorticoids are thought to involve phospholipase A2 inhibitory proteins, lipocortins, which control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes. Prednisolone reduces inflammatory reaction by limiting the capillary dilatation and permeability of the vascular structures. These compounds restrict the accumulation of polymorphonuclear leukocytes and macrophages and reduce the release of vasoactive kinins. Recent research suggests that corticosteroids may inhibit the release of arachidonic acid from phospholipids, thereby reducing the formation of prostaglandins. Prednisolone is a glucocorticoid receptor agonist. On binding, the corticoreceptor-ligand complex translocates itself into the cell nucleus, where it binds to many glucocorticoid response elements (GRE) in the promoter region of the target genes. The DNA bound receptor then interacts with basic transcription factors, causing an increase or decrease in expression of specific target genes, including suppression of IL2 (interleukin 2) expression.

News Articles on Prednisolone

Caution necessary for steroid use in dogs, cats  -  ‎Jan 4, 2010‎
EDMOND — Prednisone, Prednisolone, Dexamethazone, Triamcinalone — all medically known as glucocorticoids, or more commonly, steroids. ... Edmond Sun

Corticosteroid reduces IOP, rejection risk after corneal transplantation  -  ‎Jan 4, 2010‎
...and discontinued prednisolone acetate 1% ophthalmic suspension because of a secondary rise in IOP, which was defined as an increase of 21 mm Hg or more. OSN SuperSite

Sweetie beats the odds  -  ‎Dec 28, 2009‎
..."We are going to go to once a month," she said, continuing with CeeNU, a brand name for the chemotherapy drug lomustine, and prednisolone. ... Poughkeepsie Journal

Montelukast cannot replace prednisolone in children with stabilized acute asthma  -  ‎Dec 10, 2009‎
To investigate whether montelukast could shorten prednisolone therapy, the researchers randomized 130 children, ages 2 to 17 years, to montelukast or oral ... news Stories

Dog health insurance shoppers given anti-inflammatory advice  -  ‎Dec 11, 2009‎
Steroid anti-inflammatory drugs such as prednisone or prednisolone are often prescribed early on in the event of a serious condition such as intervertebral ... Animal Friends Pet Insurance

Radiation Pneumonitis after Radiotherapy for Breast Cancer  -  ‎Dec 30, 2009‎
The patient was given prednisolone at a dose of 100 mg once a day for 3 days, with the dose then slowly reduced, and her symptoms resolved after 5 weeks of ... New England Journal of Medicine (subscription)

Ocular Vaccinia With Severe Restriction of Extraocular Motility  -  ‎Dec 14, 2009‎
No deep stromal changes or corneal thinning were observed, and topical therapy was changed to prednisolone acetate eyedrops. Continued follow-up over months ... Archives of Ophthalmology

Ask the vet's pets: Toilet training cat is time consuming  -  ‎Dec 10, 2009‎
...a dog develops intervertebral disc disease, most veterinarians initiate therapy using a steroid anti-inflammatory, such as prednisone or prednisolone. ... Reading Eagle

What Are Insect Bites? How To Treat Insect Bites  -  ‎Dec 16, 2009‎
...itchy lumps or lesions near where the bite occurred the doctor may prescribe an oral corticosteroid, such as prednisolone, or an oral antihistamine. ... Medical News Today

STATE EX REL. DOLGENCORP, INC. v. INDUS. COMM.  -  ‎Dec 16, 2009‎
At this point she is using Prednisolone acetate drops once a day and Restasis drops twice a day for her left eye. She continues to be bothered by light ... Leagle, Inc.

Mieloma Multiplo: una nuova terapia farmacologica  -  ‎Dec 10, 2009‎
...prednisolone e Melfalan che garantiscono una maggiore sopravvivenza del paziente nei confronti di tale neoplasia seconda per diffusione solo al Linfoma ... NanoPress (Blog)

How to beat H1N1  -  14 Nov 2009
...pregnant women, patients already suffering from chronic diseases like diabetes, asthma, kidney diseases, cancer, patients on long term prednisolone etc. ... Sunday Times.lk

Living with Lupus  -  14 Nov 2009
This may include high doses of corticosteroids such as prednisolone and other drugs that suppress the immune system such as azathioprine, methotrexate, ... Sunday Times.lk

Docetaxel in combination with prednisolone for hormone refractory prostate ...  -  ‎Nov 12, 2009‎
The objective of this study was to evaluate the efficacy and toxicity of docetaxel in combination with prednisolone in Japanese patients with hormone ... UroToday

Difficult asthma may be due to difficult patients  -  ‎Oct 24, 2009‎
They also checked blood plasma prednisolone and cortisol levels to see if the patients were complying with their doctors' orders and taking their oral ... Los Angeles Times

Public urged not to take drug product with undeclared Western drug ingredients  -  ‎Nov 12, 2009‎
..."Neovidan" was found to have contained Western drug ingredients including prednisolone and mefenamic acid. Prednisolone is a steroid. ... 7thSpace Interactive (press release)

Study Examines Treatment For Olfactory Loss After Viral Infection  -  ‎Oct 20, 2009‎
Additionally, participants were randomly assigned to two treatment groups: 28 patients were treated with the steroid prednisolone for two weeks and 43 were ... Science Daily (press release)

Generic Name: Orapred, Millipred, Deltacortril, Deltastab, Prednesol  -  ‎Nov 11, 2009‎
Prednisolone is used for the treatment of a wide range of inflammatory and auto-immune conditions such as asthma, uveitis, rheumatoid arthritis, ... Pattaya Daily News

Glucocorticoid Brings Back Sense of Smell Blown Away by a Cold  -  ‎Oct 19, 2009‎
A course of prednisolone improved odor identification and lowered scent thresholds significantly in patients with postviral olfactory loss (both P<0.001), ... MedPage Today

Drug Adherence Inadequate in Refractory Asthma  -  ‎Oct 26, 2009‎
The investigators also looked at adherence with oral steroids, and found that among the 51 patients who reported current use of oral prednisolone, ... MedPage Today

Link identified between difficult asthma and non adherence  -  ‎Nov 2, 2009‎
Blood plasma prednisolone and cortisol assay levels were used to assess adherence to oral prednisolone. Factors including hospital admissions, lung function ... Nursing Times

Study seems to examine treatment for olfactory loss after viral infection  -  ‎Oct 23, 2009‎
For the group taking prednisolone, the average BTT and CCSIT score changes were noted to be 1.4 and 0.9, respectively. Besides, the group which took ... HealthJockey.com

Public urged not to use drug Neovidan  -  ‎Oct 30, 2009‎
Neovidan was found to contain prednisolone and mefenamic acid. Prednisolone is a steroid and taking it for a long time can cause side effects such as a ... News.gov.hk

Advanced Surface Ablation Following LASIK Successful: Presented at AAO-PAAO  -  ‎Oct 27, 2009‎
Postoperative medications included topical fluoroquinolone antibiotic and prednisolone acetate 1% daily for 1 week and a nonsteroidal anti-inflammatory as ... DG News

Hormone Effective for Steroid-Induced Osteoporosis  -  ‎Oct 29, 2009‎
However, long-term use of glucocorticoids such as prednisone, prednisolone, dexamethasone, and cortisone can result in reduced bone mass and strength, ... MedPage Today

Soldier says he used belt on child: Jurors view police tape in death of 2-year-old  -  ‎Oct 22, 2009‎
She pointed out that Milanya had been taking prednisolone, an allergy medicine that can cause dizziness and easy bruising. Caballero said most of the ... El Paso Times

New treatments for dry eyes  -  ‎Oct 25, 2009‎
...are typically taken over several months, similar to acne treatment • Steroids – common steroid eye drops include fluoromethalone and prednisolone. ... Examiner.com

CombinatoRx'S Synavive (CRx-102) Maintains Efficacy Throughout 12 Month Phase ...  -  ‎Oct 22, 2009‎
Synavive contains the cardiovascular agent dipyridamole and a very low dose of the glucocorticoid prednisolone and is being developed as a uniquely ... PharmaLive.com (press release)

CombinatoRx'S Synavive (CRx-102) Maintains Efficacy Throughout 12 Month Phase ...  -  ‎Oct 21, 2009‎
Synavive contains the cardiovascular agent dipyridamole and a very low dose of the glucocorticoid prednisolone and is being developed as a uniquely ... FierceBiotech

Autoimmune hepatitis  -  ‎Nov 3, 2009‎
Most centre start on 40mg prednisolone daily for 1 month before tapering the course. Azathioprine is only normally started once the results of the enzyme to ... OnMedica

Stubborn Asthma Signals Poor Use Of Medication  -  ‎Oct 27, 2009‎
Of the 51-asthma patients using oral prednisolone, blood tests showed 45% of them to be non-adherent, and on being confronted, 88% admitted to poor ... Visit Bulgaria

From Agassi to Manchester United, the classic book of drug stars' excuses  -  ‎Nov 1, 2009‎
Take Marco Borriello, the current AC Milan footballer, who was suspended for three months in 2007 after traces of prednisolone were discovered in his urine ... Sportingo

Sanofi-aventis Delivers a Solid Performance in Third Quarter 2009  -  ‎Oct 30, 2009‎
...and a portfolio of three products in clinical development: -- FOV 1101, a fixed dose combination of prednisolone and cyclosporine in eye-drop form, ... Reuters

Difficult to Control Asthma Could be Result of Poor Medicine Use - Study  -  ‎Oct 25, 2009‎
A new study has reported that people who suffer from difficult-to-control and stubborn asthma are, more often than not, irregular in their use of the ... TopNews Arab Emirates

Teriparatide outperforms alendronate in treating steroid-induced osteoporosis  -  ‎Oct 31, 2009‎
Glucocorticoid-induced osteoporosis occurs when patients taking steroid medications such as prednisone, prednisolone, dexamethasone, and cortisone exhibit ... Webnewswire.com

北縣高æŸ?森診所å?¦æ‰¿ç”¨ç°¡ç¢¼æ–¹å¼?開立類固醇  -  ‎Nov 10, 2009‎
...據媒體98å¹´11月9日報導北縣高æŸ?森耳鼻喉科診所ã€?å?‘上藥局的「Decryxinã€?Iponã€?è—¥å“?,宣稱是化痰藥,惟經媒體自行é€?驗,å?»é©—出Dexamethasoneã€?Prednisolone之類固醇 ... 自立晚報

籲市民勿æœ?「德國漢堡療濕痛膠囊ã€?  -  ‎Nov 12, 2009‎
...化驗çµ?果顯示,產å“?樣本å?«è¥¿è—¥æˆ?分包括潑尼æ?¾é¾?(prednisolone)å?Šç”²èЬ那酏(mefenamic acid)。「潑尼æ?¾é¾?ã€?屬類固醇,長期æœ?用å?¯å¼•致圓臉,高血壓ã€?高血糖å?Šèƒƒæ½°ç˜?。 香港新浪網

港å?«ç”Ÿç½²å??å‹¿æœ?“德国汉堡疗湿痛胶囊â€?  -  ‎Nov 12, 2009‎
...ç»?化验å?‘现,这一è?¯å“?样本中å?«è¥¿è?¯æˆ?分包括“泼尼æ?¾é¾™â€? (prednisolone) å?Šâ€œç”²èЬ那酏â€? (mefenamic acid)。长期æœ?用“ 泼尼æ?¾é¾™â€?会引起圆脸ã€?高血压ã€?高血糖å?Šèƒƒæºƒç–¡ã€‚ ... 希望之声国际广播电台

療濕痛å?«ç„¡æ¨™ç¤ºè¥¿è—¥æˆ?分  -  ‎Oct 29, 2009‎
...「療濕痛ã€?æ—©å‰?被發ç?¾å?«è¥¿è—¥æˆ?分,包括潑尼æ?¾é¾?(prednisolone)å?Šç”²èЬ那酏(mefenamic acid)。衞生署早å‰?已呼籲市民å?œç”¨è©²ç”¢å“?,並å?³æ™‚展開調查,發ç?¾æœ‰é—œå•†æˆ¶å·²å?œæ¥­ã€‚ ... 香港新浪網

香港å?«ç”Ÿç½²å‘¼å??æ°‘ä¼—å?œæœ?“疗湿痛â€?  -  ‎Oct 29, 2009‎
...æ?®æŠ¥é?“,“疗湿痛â€?æ­¤å‰?曾被å?‘现å?«è¥¿è?¯æˆ?分,包括泼尼æ?¾é¾™(prednisolone)å?Šç”²èЬ那酏(mefenamic acid)。其中“泼尼æ?¾é¾™â€?属类固醇,长期æœ?用å?¯å¯¼è‡´åœ†è„¸ï¼Œé«˜è¡€åŽ‹ã€?高血糖å?Šèƒƒ ... 希望之声国际广播电台

العوامل الدوائية المسببة لهشاشة العظام  -  ‎Oct 27, 2009‎
أكثرإذا تناوله المريض على شكل حبوب أو حقن بالعضل Ù?إذا كان عن طريق القم Ù?إن الجرعة المسببة للهشاشة تبدأ من7,5 مجم Prednisolone وهوأكثر الأنواع استخداما . ... الاقتصادية

Những hình ảnh khoa há»?c đột phá nhất 2009  -  ‎Oct 27, 2009‎
Trong ảnh, những hạt màu da cam là thuốc chứa chất prednisolone được dùng Ä‘iá»?u chị cho bệnh viêm khá»›p. Chúng được bao bá»?c bên ngoài bởi má»™t lá»›p đồng chất ... Báo Khoa học

Ð?амаленото обонÑ?ние Ñ?е подобрÑ?ва от Ñ?тероидна терапиÑ? 20 октомври 2009  -  ‎Oct 20, 2009‎
28 пациенти били третирани Ñ? орален prednisolone в продължение на 2 Ñ?едмици, а 43 - Ñ? prednisolon (2 Ñ?едмици) + Гинкго билоба (4 Ñ?едмици). ... DoctorBG.com

Prednisolone Steriod Drug Prevents Repeat Miscarriages | Health | Sky...  -  Sep 11, 2008
Thousands of women could be spared the misery of repeat miscarriages with a pill costing just £1 a month. Experts say a common steroid pill, used for asthma ... Sky News

Prednisolone—but not antiviral drugs—improves outcome in patients...  -  Nov 25, 2008
Prednisolone treatment (50 mg per day 10 days or 60 mg per day 5 days then tapered by 10 mg per day) improves outcome and is indicated in patients with ... Nature.com

Urgent recall of Prednisolone tablets  -  Jul 18, 2006
The Irish Medicines Board has issued an urgent recall notice for patients who have been dispensed Prednisolone tablets, BP 20mg, between 30 June and 18 July ... RTE.ie

Antiviral Won't Improve Bell's Palsy Outcome  -  Oct 17, 2007
Prednisolone stops the immune system from creating so much inflammation. ... According to Gilden, a course of prednisolone costs about $10, compared to $200 ... Washington Post

Asthma drug may end the misery of miscarriages  -  Jun 21, 2005
Treatment with the steroid prednisolone reduced levels of uterine natural killer ... "A randomised controlled trial of prednisolone for the prevention of ... Telegraph.co.uk

… of acute gout-like arthritis in an emergency setting: prednisolone...  -  Jul 15, 2007
...(2007) Comparison of oral prednisolone/paracetamol and oral ... Patients who received combination treatment with prednisolone consumed significantly higher ... Nature.com

Steroid may prevent repeated miscarriages  -  Jun 20, 2005
Quenby asked the 33 women to take the steroid prednisolone, ... Twenty-nine of the women took 20 milligrams of prednisolone daily for 21 days from the start ... New Scientist

Prednisolone eye drops recalled after mix-up found  -  May 4, 2006
Consumers shouldn't use a certain brand of eye drops because the bottles may contain another medication that carries potential health risks, Health Canada ... CBC.ca

Milan striker Borriello suspended after dope test - Europe  -  Dec 22, 2006
CONI said that Borriello's sample had shown traces of banned substances prednisone and prednisolone - which indicate the use of cortisone - while Milan said ... ESPN

CombinatoRx says arthritis drug misses primary endpoint  -  Mar 26, 2007
CombinatoRx said its CRx-102 drug, a combination of very low dose prednisolone and dipyridamole, to treat multiple immuno-inflammatory diseases, ... Reuters

… in Adding Vandetanib to Docetaxel Plus Prednisolone for Patients...  -  Mar 30, 2008
By Jill Stein. MILAN, Italy -- March 30, 2008 -- The addition of vandetanib does not enhance the efficacy of combination treatment with docetaxel plus ... DG News

No effect  -  Jan 4, 2007
Commenting on the latest cataract surgery trial, the company said: "In the trial, rEV131, dosed twice a day, was compared to prednisolone, the standard of ... Telegraph.co.uk

Leading article: When the internet is a mixed blessing  -  Aug 11, 2006
The Sunderland doctors say they were able to source 1000 tablets of the steroid prednisolone, taken by their patient, in minutes - for £25.23. ... Independent

Multi-millionaire publishing tycoon Felix Dennis 'admitted killing a...  -  Apr 2, 2008
...that at the time of the interview he was suffering from a form of anaemia and thyroid imbalance and had been prescribed Prednisolone and Carbimazole. ... Daily Mail

Warning of online drugs 'danger'  -  Aug 10, 2006
...and Dr Philip Severn, did an internet search and found they were able to find 1000 tablets of the same steroid - prednisolone 5mg - online for £25.23. ... BBC News

Xinhua - English  -  Jan 19, 2007
...will face a ban for doping as he was tested positive for the corticosteroids prednisone and prednisolone after a 2-1 defeat to AS Roma on Nov. 11. ... 新�网

… - News: First study in a GP population shows prednisolone is just...  -  May 30, 2008
They were randomly allocated to receive either prednisolone (35 mg once a day), ... They conclude that prednisolone was found to be clinically equivalent to ... OnMedica

Prednisolone Sodium Phosphate Oral : User Ratings covering uses, …  -  Oct 15, 2007
So far, the drug seems to be working for me. I am feeling better and no longer have issues w/shortness of breath or wheezing. I had recurrent bronchitis (4 ... WebMD

… Loss of Hand Bone Density With Prednisolone in Early Rheumatoid …  -  Jun 13, 2005
Glenn Haugeberg, MD, PhD; Anders Strand; Tore K. Kvien, MD, PhD; John R. Kirwan, MD. Background Bone damage in rheumatoid arthritis presents as osteoporosis ... Archives of Internal Medicine

Eye price to pay for drugs online  -  Aug 15, 2006
The condition was linked to an oral steroid, prednisolone, which the unnamed ... They also suspect that some drugs sold as prednisolone are counterfeit. ... Australian IT

Use prednisolone when IVIG fails in Kawasaki.(Infectious Diseases)  -  Oct 1, 2005
A 3-day course of prednisolone appears effective in Kawasaki disease patients who are unresponsive to multiple infusions of intravenous immunoglobulin, ... Free with registration - Pediatric News - AccessMyLibrary.com

Guinea pigs or heroes?  -  Jun 15, 2008
The docetaxel-prednisolone combination is one standard combination that is effective. This, along with all the symptomatic and supportive care, ... Malaysia Star

Effectiveness of controlled-release budesonide in preserving bone …  -  Mar 3, 2005
Systemic corticosteroids, such as prednisolone, are linked to OSTEOPOROSIS in ... To evaluate the effects of budesonide compared with prednisolone on BMD in ... Nature.com

Synavive data sends CombinatoRx to all-time lows  -  Oct 6, 2008
Synavive is the company's most advanced drug, and combined an agent called dipyridamole with the steroid prednisolone. ... Boston Globe

Salivary Cortisol Response to Prednisolone Challenge Helps Understand...  -  Sep 19, 2006
By Chris Berrie. PARIS, FRANCE -- September 19, 2006 -- The suppression of salivary cortisol levels by prednisolone provides a physiological assessment of ... DG News

… management of HELLP: prednisolone cuts exacerbations.(Obstetrics)  -  Feb 1, 2005
VIENNA -- Prolonged prednisolone administration reduces the risk of HELLP exacerbations in women undergoing expectant management remote from term, ... Free with registration - OB GYN News - AccessMyLibrary.com

Oral route for prednisolone may be best for COPD flare-ups  -  Dec 17, 2007
NEW YORK (Reuters Health) - Giving prednisolone orally rather than intravenously may be the preferred route of administration when treating patients ... news Stories

Decreased Clearance of Prednisolone, a Factor in the Development of …  -  Aug 1, 2005
Address reprint requests to Dr. Kaplan, New England Medical Center Hospital, 171 Harrison Avenue, Boston, Massachusetts 02111. ... Journal of Clinical Endocrinology and...

CombinatoRx Drug Candidate CRx-102 Demonstrates Positive Phase 2 …  -  Nov 6, 2006
CRx-102 was dosed in this trial using 3 mg of prednisolone and two different doses of dipyridamole. Patients received the first ratio for the first week of ... Free with registration - Business Wire - AccessMyLibrary.com

√ Weekly Docetaxel and Prednisolone versus Prednisolone Alone in …  -  Mar 2, 2007
BERKELEY, CA (UroToday.com) - In 2004 two large randomized clinical trials demonstrated that docetaxel based chemotherapy improved survival in ... UroToday International Journal

Why could prednisolone suppress the hepatic ischemia-reperfusion...  -  Oct 7, 2008
Hepatic ischemia-reperfusion injury is a serious complication but unavoidable problem in liver surgery including liver transplantation and hepatic resection ... eurekalert.org

Do glucocorticoids affect outcome in Graves' disease following …  -  Oct 20, 2005
Prednisolone was given to patients with pre-existing ophthalmopathy and ... Patients received 25 mg prednisolone daily for 30 days, commencing 2 days before ... Nature.com

Prednisolone Effective for Complex Regional Pain Syndrome  -  Sep 1, 2006
Clinical Question: Which is more effective for complex regional pain syndrome following stroke: prednisolone or piroxicam (Feldene)? ... AAFP News Now

Weekly Docetaxel And Prednisolone Versus Prednisolone Alone In …  -  Mar 5, 2007
UroToday.com- In 2004 two large randomized clinical trials demonstrated that docetaxel based chemotherapy improved survival in androgen-independent prostate ... Medical News Today - Medical News Today (press release)

Prednisolone Is as Effective as Naproxen for Acute Gout  -  Aug 18, 2008
A 5-day course of oral prednisolone is a reasonable alternative to NSAIDs for treating patients with acute gouty arthritis. ... Medscape

Tobramycin and Prednisolone Combination for Inflammatory Ocular …  -  Apr 28, 2005
By ISTA Pharmaceuticals, Inc., [RxPG] ISTA Pharmaceuticals, Inc. (Nasdaq: ISTA - News) announced today that the Company has filed an Investigational New ... RxPG NEWS

Data Support Prednisolone Use For Gout  -  Aug 25, 2008
A short course of a corticosteroid could supplant nonsteroidal anti-inflammatory drugs (NSAIDs) as the medication of choice to treat gout, Dutch researchers ... Renal and Urology News

Lessons from a patient with an unusual hepatic overlap syndrome  -  Feb 17, 2007
Management Combined immunosuppression with prednisolone and treatment with ursodeoxycholic ... Steroid treatment (60 mg prednisolone daily) was started and, ... Nature.com

… III Results for Tobramycin and Prednisolone Acetate Combination Pro  -  Feb 2, 2006
According to IMS Health data, prednisolone acetate is the most prescribed ... ISTA expects that its tobramycin and prednisolone acetate combination product, ... $4.95 - PR Newswire - ECNext

Prednisolone 'is as effective as existing NSAID for gout treatment'  -  Jun 10, 2008
A study has shown that the corticosteroid drug prednisolone is as effective as existing treatments for gout. Researchers from the Netherlands published ... Arthritis Research Campaign

Article: Use prednisolone when IVIG fails in Kawasaki.(Infectious …  -  Oct 1, 2005
Use prednisolone when IVIG fails in Kawasaki.(Infectious Diseases) ... find Pediatric News articles. A 3-day course of prednisolone appears effective in ... Pay-Per-View - Pediatric News - HighBeam Research

FDA issues non-approvable letter for ISTA's T-Pred  -  May 5, 2007
ISTA Pharmaceuticals Inc. announced it has received a non-approvable letter from the FDA relating to its new drug application (NDA) for prednisolone acetate ... Ophthalmology Times

Low-dose prednisolone can slow early progression of RA.(rheumatoid …  -  Jan 15, 2006
Low-dose prednisolone can slow early progression of RA.(rheumatoid arthritis ) ... find Internal Medicine News articles. Low doses of prednisolone given for ... Pay-Per-View - Internal Medicine News - HighBeam Research

Oral Prednisolone and Naproxen Found Equally Beneficial in the …  -  May 29, 2008
LONDON -- May 29, 2008 -- A recent study, reported in The Lancet, finds that naproxen and prednisolone are beneficial alternatives for nonsteroidal ... DG News

Early rheumatoid arthritis: combination therapy with disease-modifying...  -  Nov 21, 2005
...(2005) Low-dose prednisolone in addition to the initial disease-modifying ... The effect of low-dose prednisolone on disease activity and function and the ... Nature.com

Rheumatoid Arthritis an Independent Risk Factor for Stroke  -  Nov 9, 2007
Approximately 40% of RA patients received prednisolone. In patients receiving prednisolone as monotherapy, researchers found a significantly increased IRR ... Medscape

Does perioperative high-dose prednisolone have clinical benefits for ...  -  Jan 10, 2006
Objective: The purpose of this study was to clarify the clinical benefits of perioperative administration of high-dose prednisolone (PSL) combined with ... European Journal of Cardio-Thoracic...

Maintaining remission in a patient with vasculitis  -  Feb 17, 2008
Therapy with pulsed intravenous methyl prednisolone, plasma exchange and ... Although he responded transiently to an increase in prednisolone dose to 15 mg ... Nature.com

Prednisolone reduces hand bone loss in patients with early RA.( …  -  Nov 1, 2005
Haugeberg G, Strand A, Kvien TK, Kirwan JR, Diakonhjemmet Hospital, Oslo, and other centers. Reduced loss of hand bone density with prednisolone in early ... $4.95 - Journal of Musculoskeletal Medicine - ECNext

Clinical Matters: Oral prednisolone-IV hydrocortisone equivalence.(Bri...  -  Nov 3, 2007
Prednisolone 5mg orally is equivalent to 20mg of intravenous hydrocortisone, but perioperative doses may be higher than the prednisolone equivalent, ... Free with registration - Chemist & Druggist - AccessMyLibrary.com

BioMarin and Alliant Pharmaceuticals Announce North American …  -  Mar 15, 2006
Orapred is the leading brand of liquid prednisolone sodium phosphate used to treat exacerbations of asthma and other inflammatory diseases and conditions in ... Free with registration - PR Newswire - AccessMyLibrary.com

Intracameral triamcinolone, prednisolone eye drops similarly effective...  -  Apr 18, 2008
Injecting 1 mg of intracameral triamcinolone acetonide after uncomplicated phacoemulsification cataract surgery appears to control postoperative ... OSN SuperSite

… NDA to US FDA for ODT prednisolone.(BioMarin Pharmaceutical Inc., ...  -  Aug 8, 2005
BioMarin Pharmaceutical of the USA has submitted a New Drug Application to the US Food and Drug Administration for a new formulation of the ... Free with registration - Pharma Marketletter - AccessMyLibrary.com

Prednisolone aids wheezing linked to rhinovirus.(Infectious Diseases)(...  -  Aug 1, 2006
Prednisolone aids wheezing linked to rhinovirus.(Infectious Diseases)(Brief article) ... find Pediatric News articles. Children with rhinovirus who received ... Pay-Per-View - Pediatric News - HighBeam Research

CombinatoRx Announces Initiation of Phase 2b Clinical Study of CRx...  -  Sep 26, 2007
Patients will be randomized to three different doses of CRx-102 (2.7mg prednisolone and 360mg, 180mg or 90mg of dipyridamole), 2.7mg of prednisolone alone ... Free with registration - Business Wire - AccessMyLibrary.com

Cat's painful stomatitis has no cure .  -  Jan 2, 2008
Low-dose, every-other-day prednisolone helps, but if I stop the medication, ... I am afraid the prednisolone, a steroid, will trigger diabetes. ... Reading Eagle - Google News Archive

Article: Prednisolone effective when IVIG fails in Kawasaki disease.(...  -  Sep 1, 2005
Prednisolone effective when IVIG fails in Kawasaki disease.(Clinical Rounds) ... find Skin & Allergy News articles. A 3-day course of prednisolone appears ... Pay-Per-View - Skin & Allergy News - HighBeam Research

… inhaled fluticasone does not replace oral prednisolone in children...  -  Aug 1, 2006
...inhaled fluticasone with that of oral prednisolone in children [greater than ... Trudell Medical) and prednisolone placebo syrup in the ED (fluticasone ... $4.95 - Pediatrics - ECNext

Drug Companies Get Healthy, but at Whose Expense?  -  Jul 23, 2008
The team turned up a study from the United Kingdom that gave infants high doses of prednisolone, a well-known, generic steroid. ... Wired News

… - 21 CFR § 522.1884 Prednisolone sodium succinate injection.  -  Jul 11, 2006
21 CFR § 522.1884 Prednisolone sodium succinate injection. (a) Chemical name. 11 beta, 17, 21-Trihydroxypregna-1, 4-diene-3, 20-dione 21-succinate sodium ... Pay-Per-View - United States Code of Federal Regulation... - Loislaw

News briefs from the December issue of Chest  -  Dec 10, 2007
New research from the Netherlands suggests that oral prednisolone is just as effective ... Prednisolone, which is a corticosteroid, was administered to 435 ... eurekalert.org

Orapred ODT Arrives in US Market  -  Aug 28, 2006
Orapred ODT(TM) (prednisolone sodium phosphate orally disintegrating tablets) is marketed in the United States by Alliant Pharmaceuticals, pursuant to a ... RedOrbit

THALIDOMIDE TO MYELOMA THERAPIES CAN ENHANCE CLINICAL …  -  Dec 13, 2006
The thalidomide plus prednisolone arm showed superior progression-free survival, with estimates at one, two and three years of 90 per cent, 66 per cent and ... Free with registration - AsiaPulse News - AccessMyLibrary.com

Polymyositis initiation involving amlodipine besylate.  -  Jan 1, 2006
We have shown [2] that if the prednisolone is taken every second day the heart rate is ... Since day 2 is approximately independent of the prednisolone ... Free with registration - American Journal of Immunology - AccessMyLibrary.com

… Trial of Tacrolimus, Azathioprine and Prednisolone With or Without...  -  Aug 18, 2008
A total of 192 children and adolescents undergoing renal transplantation were randomly chosen to receive tacrolimus, azathioprine and corticosteroids (TAS, ... UroToday International Journal

Many Uses, Use Caution with ... on Prednisolone Tabs 5 MG, Medication...  -  Mar 9, 2008
By Category. By Pet. We've been prescribed this for a variety of reasons over the years - inflammation due to various causes such as arthritis, injuries, ... Zootoo.com

BioMarin Announces Second Quarter 2006 Financial Results.  -  Aug 2, 2006
...following FDA approval of Orapred ODT(TM) (prednisolone sodium phosphate ... the first orally disintegrating tablet form of prednisolone available in ... Free with registration - PR Newswire - AccessMyLibrary.com

Is low-dose ciclosporin an effective treatment for membranous …  -  Nov 30, 2006
Prednisolone (starting dose 0.6 mg/kg/day) was administered to the patients who ... Prednisolone dosing was reduced to 10–15 mg/day for the final 6 months. ... Nature.com

Re-induction of hormone sensitivity to diethylstilboestrol in...  -  Jan 8, 2008
In January 2006, prednisolone (10 mg daily) was unsuccessfully tried following further ... On completion of six cycles in August 2006, the prednisolone was ... Nature.com

NICE Recommends Rituximab For The First Line Treatment Of Follicular ...  -  Sep 30, 2006
Combination therapies CVP (cyclophosphamide, vincristine and prednisolone) and CHOP (cyclophosphamine, doxorubicin, vincristine and prednisolone) are also ... Medical News Today - Medical News Today (press release)

Impact of acute and chronic low-dose glucocorticoids on protein …  -  Mar 1, 2008
Results: Prednisolone induced an acute significant increase in Lox (p=0.008) and a fall in LIP (p=0.08), but did not affect leucine Ra. ... Journal of Clinical Endocrinology and...

… - 21 CFR § 524.1881b Prednisolone acetate-neomycin sulfate sterile...  -  Jul 11, 2006
21 CFR § 524.1881b Prednisolone acetate-neomycin sulfate sterile suspension. (a) Specifications. Prednisolone acetate-neomycin sulfate sterile suspension ... Pay-Per-View - United States Code of Federal Regulation... - Loislaw

… States Code of Federal Regulations - 21 CFR § 520.1880 Prednisolone...  -  Jul 11, 2006
Each tablet contains 5 or 20 milligrams prednisolone. (b) Sponsor. ... Systemic therapy with prednisolone is contraindicated in animals with peptic ulcer, ... Pay-Per-View - United States Code of Federal Regulation... - Loislaw

… - 21 CFR § 522.1885 Prednisolone tertiary butylacetate suspension.  -  Jul 11, 2006
21 CFR § 522.1885 Prednisolone tertiary butylacetate suspension. (a) Specifications. Prednisolone tertiary butylacetate (Pregna-1,4-diene-3, 20-dione-11B, ... Pay-Per-View - United States Code of Federal Regulation... - Loislaw

… surgery lidocaine and prednisolone have opposite postoperative...  -  Mar 14, 2006
2006 MAR 14 - (NewsRx.com) -- Lidocaine and prednisolone have opposite effects on the outcome of endoscopic rigid laryngoscopy. ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

… States Code of Federal Regulations - 21 CFR § 522.1883 Prednisolone...  -  Jul 11, 2006
21 CFR § 522.1883 Prednisolone sodium phosphate. (a) Specifications. Each milliliter of solution contains 20 milligrams (mg) prednisolone sodium phosphate ... Pay-Per-View - United States Code of Federal Regulation... - Loislaw

Clinical Matters: Oral prednisolone-IV hydrocortisone equivalence.(Bri...  -  Nov 3, 2007
Prednisolone 5mg orally is equivalent to 20mg of intravenous hydrocortisone, but perioperative doses may be higher than the prednisolone equivalent, ... $4.95 - Chemist & Druggist - ECNext

… - 21 CFR § 524.1880 Prednisolone-neomycin sulfate ophthalmic …  -  Jul 11, 2006
Prednisolone-neomycin sulfate ophthalmic ointment contains 2 milligrams prednisolone and 5 milligrams neomycin sulfate (equivalent to 3.5 milligrams ... Pay-Per-View - United States Code of Federal Regulation... - Loislaw

… - 21 CFR § 522.1881 Sterile prednisolone acetate aqueous suspension...  -  Jul 11, 2006
21 CFR § 522.1881 Sterile prednisolone acetate aqueous suspension. (a) Specifications. Each milliliter of sterile aqueous suspension contains 25 milligrams ... Pay-Per-View - United States Code of Federal Regulation... - Loislaw

Press Release: ISTA Pharmaceuticals Files IND to Commence US Phase …  -  Apr 27, 2005
ISTA Pharmaceuticals Files IND to Commence US Phase III Studies for Tobramycin and Prednisolone Acetate Combination Product; New Combination Product in ... Pay-Per-View - PR Newswire - HighBeam Research

Data on CombinatoRx Drug Candidates CRx-102 and CRx-139 to Be …  -  Nov 3, 2006
CRx-102 contains the cardiovascular drug dipyridamole and an unconventionally low dose of the steroid prednisolone. CRx-139 contains paroxetine, an SSRI, ... Genetic Engineering News - Genetic Engineering News (press release)

… States Code of Federal Regulations - 21 CFR § 556.520 Prednisolone.  -  Jul 11, 2006
21 C.F.R. § 556.520 Prednisolone. A tolerance of zero is established for residues of prednisolone in milk from dairy animals. ... Pay-Per-View - United States Code of Federal Regulation... - Loislaw

… Regulations - 21 CFR § 524.390d Chloramphenicol-prednisolone …  -  Jul 11, 2006
21 CFR § 524.390d Chloramphenicol-prednisolone ophthalmic ointment. (a) Specifications. Each gram contains 10 milligrams of chloramphenicol and 2.5 ... Pay-Per-View - United States Code of Federal Regulation... - Loislaw

Brass Hat Disqualified From Second in Dubai World Cup  -  May 4, 2006
The owner and trainer do not dispute that the 5-year-old Prized gelding was administered methyl prednisolone acetate, but they believe they were misled by a ... BloodHorse

For Bell's palsy, start steroids early; no need for an antiviral.(NEW...  -  Jan 1, 2008
A 10-day course of corticosteroids (prednisolone 25 mg twice daily) started within 72 ... Early treatment with prednisolone or acyclovir in Bell's palsy. ... Free with registration - Journal of Family Practice - AccessMyLibrary.com

Methyl-prednisolone sodium succinate for injection, USP.(NEW …  -  Mar 19, 2007
Bedford Laboratories, Bedford, Ohio, (440) 232-i 3320, will begin shipping methylprednisolone sodium succinate for injection, USP. $4.95 - Drug Topics - ECNext

Independent Nurse: Journals Watch - Prednisolone may increase risk of...  -  Mar 31, 2006
A three-year study of 16788 patients with rheumatoid arthritis found prednisolone increased the risk of pneumonia hospitalisation by 70 per cent overall. ... Pay-Per-View - GP - Factiva, from Dow Jones

Methyl-prednisolone sodium succinate for injection, USP.  -  Mar 19, 2007
Methyl-prednisolone sodium succinate for injection, USP. Bedford Laboratories, Bedford, Ohio, (440) 232-i 3320, will begin shipping methylprednisolone ... $9.94 - Drug Topics - Alacra Store

… Regulations - 21 CFR § 524.1881 Prednisolone acetate ophthalmic...  -  Jul 11, 2006
21 C.F.R. § 524.1881 Prednisolone acetate ophthalmic and topical dosage forms. Copyright © 2009 Loislaw.com, Inc. All Rights Reserved. Pay-Per-View - United States Code of Federal Regulation... - Loislaw

… Administrative Code - 77 Ill. Adm. Code 790.7340 PREDNISOLONE …  -  Aug 10, 2005
77 Ill. Adm. Code 790.7340 PREDNISOLONE ACETATE; SULFACETAMIDE SODIUM (Repealed) Repealed. (Source: Repealed at 17 Ill. Reg. 15916, effective September 20, ... Pay-Per-View - Illinois Administrative Code - Loislaw

… Administrative Code - 77 Ill. Adm. Code 790.7380 PREDNISOLONE …  -  Aug 10, 2005
77 Ill. Adm. Code 790.7380 PREDNISOLONE SODIUM PHOSPHATE (Repealed) Repealed. (Source: Repealed at 17 Ill. Reg. 15916, effective September 20, 1993) ... Pay-Per-View - Illinois Administrative Code - Loislaw

Prednisolone may reduce miscarriage.(Brief Article)  -  Jun 25, 2005
Scientists in Denmark have reported that prednisolone may have a role in reducing the incidence of recurrent miscarriage. Emerging findings have shown that ... $4.95 - Chemist & Druggist - ECNext

… Administrative Code - 77 Ill. Adm. Code 790.7300 PREDNISOLONE …  -  Aug 10, 2005
77 Ill. Adm. Code 790.7300 PREDNISOLONE ACETATE (Repealed) Repealed. (Source: Repealed at 17 Ill. Reg. 15916, effective September 20, 1993) ... Pay-Per-View - Illinois Administrative Code - Loislaw

Borriello set for lengthy doping ban  -  Jan 18, 2007
Borriello, 24, tested positive for catabolic steroids prednisone and prednisolone. Unlike anabolic steroids which build the body up, catabolic steroids ... Soccerway

A new drug improves long term survival for mantle cell lymphoma  -  Jul 2, 2007
The usual treatment is MCP(mitoxantrone, chlorambucil, and prednisolone), a type of chemotherapy. The Journal of Clinical Oncology found that by adding ... TopCancerNews.com

Severe asthma attacks - evaluating who is at risk  -  Nov 1, 2005
Most asthma patients are well controlled by inhaled medications, but a small subset suffers from recurrent severe attacks requiring oral prednisolone, ... Medical News Today - Medical News Today (press release)

Pharmacy update: The lopsided face.(symptoms and treatment of Bell's ...  -  Nov 18, 2006
Prednisolone 60mg daily for five days then reduce by 10mg daily until finished. ... You explain to Esther that the prednisolone has been prescribed as an ... $4.95 - Chemist & Druggist - ECNext

BioMarin Pharmaceutical Inc acquires API-Orapred NA Brand Rights from...  -  Mar 15, 2006
The license agreement grants BioMarin the exclusive worldwide rights to ORAPRED (prednisolone sodium phosphate), including proprietary… ... Pay-Per-View - deals - Alacra Store

Phase II Results Positive For CombinatoRx's Asthma Drug.  -  Apr 19, 2006
The company's pipeline also includes CRx-139 (prednisolone plus a selective serotonin reuptake inhibitor) and CRx-150 (an antidepressant plus a ... Pay-Per-View - BIOWORLD Today - Factiva, from Dow Jones

A systematic review of the effectiveness of docetaxel and mitoxantrone...  -  Apr 28, 2006
A systematic review was performed to evaluate the clinical effectiveness of docetaxel in combination with prednisolone (docetaxel is licensed in the UK for ... Nature.com

Brand Names/Synonyms:
Prednisolone is also known by the following brand names and/or synonyms.Delta.-Cortef; .Delta.-Stab; A-Methapred; Ak-Pred; Ak-Tate; Alphadrol; Articulose-50; CCRIS 980; Chloroptic-P S.O.P.; Co-Hydeltra; Codelcortone; Cordrol; Cortalone; Cotogesic; Cotolone; Decaprednil; Decortin H; Delcortol; Delta F; Delta-Cortef; Delta-Stab; Deltacortenol; Deltacortril; Deltacortril Enteric; Deltahydrocortisone; Deltasolone; Deltisilone; Depo-Medrol; Derpo Pd; Dexa-Cortidelt Hostacortin H; Di-Adreson F; Dicortol; Donisolone; Dydeltrone; Eazolin D; Econopred; Econopred Plus; Erbacort; Erbasona; Estilsona; Fernisolone; Fernisolone P; Fernisolone-P; Flamasone; HSDB 3385; Hostacortin H; Hydeltra; Hydeltra-Tba; Hydeltrasol; Hydeltrone; Hydrodeltalone; Hydrodeltisone; Hydroretrocortin; Hydroretrocortine; I-Pred; Inflamase Forte; Inflamase Mild; K 1557; Key-Pred; Klismacort; Lentosone; Lite Pred; M-Predrol; Medrol; Medrol Acetate; Metacortandralone; Methylprednisolone; Methylprednisolone Acetate; Methylprednisolone Sodium Succinate; Meti-Derm; Meticortelone; Meticortelone;Sterolone; Metreton; NSC 9120; NSC9900; Nisolone; Nor-Pred T.B.A.; Ocu-Pred; Ocu-Pred Forte; Ophtho-Tate; Orapred; PRDL; Panafcortelone; Paracortol; Paracotol; Pediapred; Precortalon; Precortancyl; Precortilon; Precortisyl; Pred Forte; Pred Mild; Predair; Predair A; Predair Forte; Predalone 50; Predalone T.B.A.; Predate Tba; Predate-50; Predcor-25; Predcor-50; Predcor-Tba; Predisolone Sodium Phosphate; Predne-Dome; Prednelan; Predni-Dome; Prednicen; Predniliderm; Predniretard; Prednis; Prednisolona [Inn-Spanish]; Prednisolone; Prednisolone Acetate; Prednisolone Sodium Phosphate; Prednisolone Tebutate; Prednisolone [Ban:Inn:Jan]; Prednisolonum [Inn-Latin]; Predonin; Predonine; Prelone; Prenolone; Rolisone; Scherisolon; Solone; Solu-Medrol; Steran; Sterane; Sterolone; Supercortisol; Ulacort; Ultra Pred; Ultracorten H; Ultracortene H; Ultracortene-H; Ultracortene-Hydrogen

Drug Category:
Prednisolone is categorized under the following by the FDA: Antineoplastic Agents; Glucocorticoids; Anti-inflammatory Agents; Adrenergic Agents; ATC:A07EA01; ATC:C05AA04; ATC:D07AA01; ATC:D07AA03; ATC:D07AC14;

Dosage Forms:
SOLUTION

Absorption:
Readily absorbed by gastrointestinal tract, peak plasma concentration is reached 1-2 hours after administration

Interactions:
Not Available



Chemical IUPAC Name:
11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one





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