Procarbazine

This page contains recent news articles, when available, and an overview of Procarbazine but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Procarbazine
(when available)

Pharmacology and use:
Procarbazine is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer. Alkylating agents are so named because of their ability to add alkyl groups to many electronegative groups under conditions present in cells. They stop tumor growth by cross-linking guanine bases in DNA double-helix strands - directly attacking DNA. This makes the strands unable to uncoil and separate. As this is necessary in DNA replication, the cells can no longer divide. In addition, these drugs add methyl or other alkyl groups onto molecules where they do not belong which in turn inhibits their correct utilization by base pairing and causes a miscoding of DNA. Procarbazine is cell-phase specific for the S phase of cell division. For use with other anticancer drugs for the treatment of stage III and stage IV Hodgkin's disease.

Mechanism Of Action:
The precise mode of cytotoxic action of procarbazine has not been clearly defined. There is evidence that the drug may act by inhibition of protein, RNA and DNA synthesis. Studies have suggested that procarbazine may inhibit transmethylation of methyl groups of methionine into t-RNA. The absence of functional t-RNA could cause the cessation of protein synthesis and consequently DNA and RNA synthesis. In addition, procarbazine may directly damage DNA. Hydrogen peroxide, formed during the auto-oxidation of the drug, may attack protein sulfhydryl groups contained in residual protein which is tightly bound to DNA.

News Articles on Procarbazine

Risk factors for decreased fertility among male cancer survivors identified  -  05 Jan 2010
...agent dose score or treatment with cyclophosphamide or procarbazine (Matulane, Sigma-Tau) were all associated with decreased HR for siring a pregnancy. HemOncToday

Procarbazine (Systemic).(Drug overview)  -  Aug 1, 2006
Procarbazine ( pro-KAR-ba-zeen) belongs to the group of medicines known as alkylating agents. It is used to treat some kinds of cancer. ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Procarbazine (Systemic).  -  May 1, 2006
Procarbazine ( pro-KAR-ba-zeen) belongs to the group of medicines known as alkylating agents. It is used to treat some kinds of cancer. ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

… Not Superior to Procarbazine-Based Combination Treatment in...  -  Sep 18, 2008
By Ed Susman. STOCKHOLM, Sweden -- September 18, 2008 -- Treating patients with temozolomide monotherapy is not more effective than the standard therapy of ... DG News

Drugs Five Years Later: Procarbazine -- SPIVACK 81 (6): 795 -- Annals...  -  Sep 1, 2006
Since its approval by the Food and Drug Administration (FDA) in 1969 procarbazine has had an established role as a single agent in combination chemotherapy ... Annals of Internal Medicine

How It Works  -  Apr 22, 2008
Procarbazine is used to treat leukemia and non-Hodgkin's lymphoma. ... Procarbazine is an effective treatment for non-Hodgkin's lymphoma. ... WebMD

Brain Tumor - Children Chemotherapy - Brain Tumor - Children Health …  -  Jun 10, 2008
Procarbazine and lomustine are taken by mouth. ... Procarbazine can cause high blood pressure when taken with foods high in tyramine. ... New York Times

Hydrazine Sulfate: Complementary and alternative medicine - Patient …  -  Jul 17, 2007
One of these compounds, procarbazine, has been used to treat Hodgkin disease, melanoma, and lung cancer since the 1960s. ... MSN Health & Fitness

High incidence of late effects found in Hodgkin's lymphoma survivors,...  -  Nov 15, 2005
Of whom, 42 (72%) also received chemotherapy (10 different regimens, the most frequent being LOPP (LOPP=Chlorambucil, Vincristine, Procarbazine, ... Nature.com

Should patients with anaplastic oligodendroglial tumors receive...  -  Sep 22, 2006
...(2006) Adjuvant procarbazine, lomustine, and vincristine improves progression-free survival but not overall survival in newly diagnosed anaplastic ... Nature.com

Inspired to help children abroad after cancer battle  -  Feb 19, 2008
At the moment, patients receive Procarbazine, an oral chemotherapy drug which can cause infertility, then large dozes of radiotherapy, which can cause ... Scotsman

Should patients with anaplastic oligodendroglial tumors receive...  -  Aug 17, 2006
...(2006) Adjuvant procarbazine, lomustine, and vincristine improves progression-free survival but not overall survival in newly diagnosed anaplastic ... Nature.com

Article: COPP.(Obit) - The Post-Standard (Syracuse, NY) | HighBeam …  -  Oct 31, 2005
Both of the studied treatments ... Sagar and coauthors found. They examined the outcomes of COPP (cyclophosphamide, vincristine, procarbazine, and ... ... Pay-Per-View - Post-Standard - HighBeam Research

ANTIHISTAMINE (Oral route, Parenteral route, Rectal route).(Drug …  -  May 1, 2007
Procarbazine * Prochlorperazine * Propafenone * Protriptyline * Quetiapine * Quinidine * Quinupristin * Risperidone * Roxithromycin * Sematilide ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Escalated BEACOPP Chemotherapy Improves Long-Term Outcome in …  -  Dec 10, 2007
Ten-year survival with standard BEACOPP was 80%, and it was 75% with a regimen based on COPP (cyclophosphamide, vincristine, procarbazine, and prednisone) ... DG News

TEMODAL (R) After Surgery Significantly Improves Survival in Patients...  -  Oct 31, 2005
...(FDA) in March 2005 for refractory AA in patients who have experienced disease progression on a drug regimen containing nitrosurea and procarbazine, ... $4.95 - PR Newswire - ECNext

CHMP Recommends Approval In The European Union (EU) For New …  -  Dec 9, 2008
...as well as for refractory AA, ie, patients who have experienced disease progression on a drug regimen containing nitrosourea and procarbazine. ... Medical News Today - Medical News Today (press release)

Maryland Code of Regulations - 26.11.16.06 Class I Toxic Air Pollutant...  -  Aug 4, 2005
...(143) -- Polychlorinated biphenyls (PCBs); (144) 7758-01-2 Potassium bromate; (145) 671-16-9 Procarbazine; (146) 366-70-1 Procarbazine hydrochloride; ... Pay-Per-View - Maryland Code of Regulations - Loislaw

Standard Care in Advanced Hodgkin's Lymphoma  -  Dec 12, 2006
...with a regimen known as escalated BEACOPP, comprising bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone. ... Medscape

Press Release: FDA Approves TEMODAR(R) (temozolomide) as …  -  Mar 16, 2005
Administration has granted accelerated approval to TEMODAR(TM) (temozolomide) Capsules for the ... procarbazine-containing drug regimen. ... Pay-Per-View - PR Newswire - HighBeam Research

Tramadol and Acetaminophen ( Systemic).  -  Feb 1, 2006
...and medicines with Monoamine oxidase (MAO) inhibitor activity (isocarboxazid [eg, Marplan], phenelzine [eg, Nardil], procarbazine [eg, Matulane], ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Hodgkin Lymphoma; Factors affecting amenorrhea in women with …  -  Dec 26, 2005
...cycles of dose-escalated bleomycin etoposide doxorubicin cyclophosphamide vincristine procarbazine and prednisone (BEACOPP) had continuous amenorrhea." ... Pay-Per-View - OBGYN & Reproduction Week - Factiva, from Dow Jones

Tramadol and Acetaminophen ( Systemic).(Drug overview)  -  May 1, 2006
...and medicines with Monoamine oxidase (MAO) inhibitor activity (isocarboxazid [eg, Marplan], phenelzine [eg, Nardil], procarbazine [eg, Matulane], ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Italian Drug Firm Draws Fire for Boosting Prices  -  Jun 1, 2005
The drug, whose generic name is procarbazine hydrochloride, typically is used ... "There's no justifying why this company should buy procarbazine and raise ... Subscription - Wall Street Journal Online - Dow Jones & Company

Myelodysplastic syndromes  -  Oct 13, 2007
Probably the most clear-cut cause of myelodysplastic syndromes is treatment with certain chemotherapy drugs, among them mechlorethamine, procarbazine and ... CNN

Astrocytoma; Magnetic resonance spectroscopy of oligodendroglial …  -  Aug 23, 2005
..."Oligodendroglial neoplasms with combined loss of chromosomes 1p and 19q may have a good prognosis and respond to procarbazine-lomustine (CCNU)-vincristine ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

Dinh dưỡng và Ä‘iá»?u trị ung thư  -  Jul 24, 2008
Ví dụ, procarbazine, methotrexate, temozolomide là những hóa chất đi�u trị ung thư, nếu sử dụng thực phẩm có cafein sẽ làm tăng huyết áp ở bệnh nhân đang ... Tin nhanh

Chemo Alone Effective in Treating Kids' Brain Tumors  -  Oct 10, 2008
The study of 401 patients found that a regimen of thioguanine, procarbazine, lomustine and vincristine (TPCV) was more effective than a carboplatin and ... BusinessWeek

Scots medics pioneer children's cancer cure that preserves fertility  -  Dec 30, 2007
One commonly used chemotherapy drug, procarbazine, will be removed from the treatment regime because it has the side-effect of affecting patients' fertility ... Scotland on Sunday

轉貼--末期何æ?°é‡‘æ°?淋巴瘤標準照護的挑戰  -  Dec 12, 2006
Diehl醫師於會中發表,�果顯示,一種漸強�的BEACOPP處方( 包括bleomycin�etoposide�doxorubicin�cyclophosphamide�vincristine�procarbazine 以�prednisone) ... udn.com

Long-term survival and transmission of INI1-mutation via nonpenetrant...  -  Aug 30, 2007
...brain tumour almost 2 years after removal of the primary brain tumour and treatment with chemotherapy (vincristine, procarbazine, and methotrexate). ... Nature.com

Drug prevents male fertility loss after chemotherapy  -  Jun 20, 2006
When the experiment was repeated with the chemotherapy drugs cyclophosphamide and procarbazine, AS101 showed an even better protective effect. ... New Scientist

Hodgkin's Lymphoma During Pregnancy  -  Jul 17, 2007
9,10] However, in one series, there were no adverse effects in 14 children of mothers who received mechlorethamine + vincristine + procarbazine + prednisone ... WebMD

Successful salvage with unrelated umbilical cord blood transplant for...  -  May 5, 2008
The patient received two cycles of mustine, vincristine, procarbazine and prednisone while waiting for the insurance approval and procurement of the UCB. ... Nature.com

Pleurisy.  -  May 1, 2007
...not available in the United States), practolol (Eraldin; not available in the United States), procarbazine (Matulane), and sclerotherapeutic agents. ... $4.95 - American Family Physician - ECNext

Using molecular information to guide brain tumor therapy  -  Oct 28, 2005
...and others demonstrated that anaplastic oligodendroglioma patients who have tumors bearing chromosome 1p loss almost always respond to procarbazine, ... Nature.com

Medicines and alcohol  -  Sep 28, 2005
Cytotoxics – A disulfiram reaction can occur when alcohol is taken with procarbazine. The reaction has been described above in relation to the ... Malaysia Star

DRUG CAPSULE WHAT YOU SHOULD KNOW  -  Jan 15, 2007
...taking monoamine oxidase inhibitors (eg, furazolidone, isocarboxazid, linezolid, moclobemide, phenelzine, procarbazine, selegiline, tranylcypromine). $2.95 - Milwaukee Journal Sentinel - NewsBank

High-dose chemotherapy with autologous stem cell transplantation as...  -  Apr 11, 2006
A recent publication showed encouraging results with chemotherapy alone combining high-dose methotrexate, lomustine, procarbazine and methylprednisone in ... Nature.com

DRUG CAPSULE WHAT YOU SHOULD KNOW | Article from The …  -  Jan 15, 2007
...taking monoamine oxidase inhibitors (e.g., furazolidone, isocarboxazid, linezolid, moclobemide, phenelzine, procarbazine, selegiline, tranylcypromine). ... Pay-Per-View - Milwaukee Journal Sentinel - HighBeam Research

Milwaukee Journal Sentinel : DRUG CAPSULE WHAT YOU SHOULD …  -  Jul 4, 2005
Interactions: This drug should not be taken with MAO inhibitors (e.g., furazolidone, isocarboxazid, linezolid, moclobemide, phenelzine, procarbazine, ... $2.95 - Milwaukee Journal Sentinel - NewsBank

Pediatric study finds alternatives for radiation of low-grade brain...  -  Oct 6, 2008
However, the COG trial with 401 patients enrolled, showed that a thioguanine, procarbazine, lomustine and vincristine (TPCV) regimen was more effective than ... RxPG NEWS

St. Paul Pioneer Press : MANY MEDS DON'T MIX WITH THE SUN  -  Sep 21, 2005
...epirubicin (Ellence), fluorou-racil (5-FU), interferon alfa (Intron A, Alferon-N), metho-trexate (Mexate) pentostatin (Nipent), procarbazine (Matulane), ... $2.95 - St. Paul Pioneer Press - NewsBank

DRUG CAPSULE WHAT YOU SHOULD KNOW  -  Dec 11, 2006
Do not take MAO inhibitors (eg, furazolidone, linezolid, phenelzine, procarbazine) for at least two weeks before or after taking this drug. ... $2.95 - Milwaukee Journal Sentinel - NewsBank

DRUG CAPSULE WHAT YOU SHOULD KNOW | Article from The …  -  Jul 4, 2005
Interactions: This drug should not be taken with MAO inhibitors (e.g., furazolidone, isocarboxazid, linezolid, moclobemide, phenelzine, procarbazine, ... Pay-Per-View - Milwaukee Journal Sentinel - HighBeam Research

PhytoMedical's Anti-Cancer Compound Effective at Killing Brain Cancer...  -  Jan 3, 2008
...given these cells' strong resistance to currently available anticancer drugs such as Lomustine, Carmustine, Nitrosourea, Hydroxyurea, and Procarbazine. ... Free with registration - Business Wire - AccessMyLibrary.com

Adding Thalidomide to Standard Therapy Improves Survival in Newly …  -  Jun 4, 2007
A Phase II trial of thalidomide (Thal) and procarbazine (Pro) in adults with recurrent or progressive malignant gliomas (MG) -- G. Lesser, MD; ... Free with registration - PR Newswire - AccessMyLibrary.com

Malignant Gliomas in 2005 Where to GO From Here?  -  Feb 2, 2005
13 Chemotherapy regimens used at the time of the GO Project, such as carmustine or procarbazine, lomustine, and vincristine, have been found to have minimal ... Journal of American Medical Association - Journal of American Medical Association...

Male Patients with Hodgkin Lymphoma Face High Risk of Infertility  -  Feb 4, 2008
...doxorubicin, cyclophosphamide, vincristine, procarbazine and prednisone) therapy. The median age was 26; most patients were in clinical stage III. ... Cancerpage.com

Unexpected "donut hole" raises concerns that patients will fail to...  -  Dec 1, 2006
...thioguanine, bexarotene, erlotinib, exemestane, anastrozole, megestrol acetate, tamoxifen, chlorambucil, procarbazine, altretamine, and others. ... Free with registration - ONS News - AccessMyLibrary.com

A study of soft tissue sarcomas after childhood cancer in Britain  -  Mar 14, 2007
Procarbazine, an alkylating agent, was also an independent risk factor for STS (Menu-Branthomme et al, 2004). Conclusions from case–control studies ... Nature.com

RealPennies.com: Turning Pennies into dollars: (Pink Sheets: IDGJ),( …  -  Jan 8, 2008
...given these cells' strong resistance to currently available anticancer drugs such as Lomustine, Carmustine, Nitrosourea, Hydroxyurea, and Procarbazine. ... Free with registration - M2 Presswire - AccessMyLibrary.com

Second primary cancers among 109 000 cases of non-Hodgkin's …  -  Jun 21, 2005
...after NHL due to specific chemotherapy regimes including the multi-drug protocol MOPP (nitrogen mustard, vincristine, procarbazine and prednisone). ... Nature.com

Before the Bell Report for Friday, January 4th, 2008 - On the Radar: ...  -  Jan 4, 2008
...given these cells' strong resistance to currently available anticancer drugs such as Lomustine, Carmustine, Nitrosourea, Hydroxyurea, and Procarbazine. ... Free with registration - M2 Presswire - AccessMyLibrary.com

Spain establishes new laws to protect animal health  -  Feb 9, 2007
Procarbazine as adjunctive therapy for treatment of dogs with presumptive antemortem diagnosis of granulomatous meningoencephalomyelitis: 21 cases ... animalpharmnews.com

Sterility uncommon in women after childhood cancer  -  May 30, 2006
...factors included increasing doses of ovarian radiation (at least 1000-cGy), exposure to procarbazine and to cyclophosphamide between 13 to 20 years old. ... Dominican Today

APPETITE SUPPRESSANT, SYMPATHOMIMETIC (Oral route).(Drug …  -  May 1, 2007
Procarbazine * Selegiline * Sibutramine * Toloxatone * Tranylcypromine Using medicines in this class with any of the following medicines is usually not ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Temodar Approved for Glioblastoma Multiforme  -  Mar 17, 2005
...treatment of adult patients with another form of brain tumor ( anaplastic astrocytoma ) in relapse after chemotherapy with nitrosourea and procarbazine. ... i-newswire.com

Temodar Approved for Glioblastoma Multiforme  -  Mar 16, 2005
...treatment of adult patients with another form of brain tumor (anaplastic astrocytoma) in relapse after chemotherapy with nitrosourea and procarbazine. ... Medical News Today - Medical News Today (press release)

Sumatriptan (Systemic).  -  Aug 1, 2006
Monoamine oxidase (MAO) inhibitor activity (isocarboxazid [eg, Marplan], phenelzine [eg, Nardil], procarbazine [eg, Matulane], selegiline [eg, Eldepryl], ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

AUA NY Section 2007 - The Effect of Urologic Disorders and Treatments...  -  Nov 20, 2007
...and procarbazine) were contrasted with other agents. Additionally the dose relationship of radiotherapy and abnormal spermatogenesis was highlighted. ... UroToday International Journal

Chemotherapy affects executive function, verbal memory.(Clinical …  -  Feb 15, 2005
Cognitive or Motor Impairment L-asparagine Busulfan Hexamethylmelamine Procarbazine Thiotepa * Also associated with cognitive impairment individually. ... Free with registration - Family Practice News - AccessMyLibrary.com

Schering-Plough uses OMS Technology in new deal  -  Nov 17, 2005
Temodar is indicated for use in adult patients who have experienced disease progression on a drug regimen containing nitrosourea and procarbazine. ... DrugResearcher.com

Identify, treat depression in cancer patients.(Psychosomatic Medicine)...  -  Nov 1, 2005
Dr. Weihs noted that procarbazine inhibits dopamine beta-hydroxylase, while vincristine and vinblastine decrease conversion of dopamine to norepinephrine. ... Free with registration - Clinical Psychiatry News - AccessMyLibrary.com

Primidone (Systemic).  -  Oct 27, 2005
Marplan], phenelzine [eg, Nardil], procarbazine [eg, Matulane], selegiline [eg, Eldepryl], tranylcypromine [eg, Parnate]) -- Taking primidone while you ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Atomoxetine (Systemic).  -  Jul 28, 2005
Monoamine oxidase (MAO) inhibitor activity (isocarboxazid [eg, Marplan], phenelzine [eg, Nardil], procarbazine [eg, Matulane], selegiline [eg, Eldepryl], ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Levalbuterol (Inhalation-Local).  -  Jul 28, 2005
Nardil], procarbazine [eg, Matulane], selegiline [eg, Eldepryl], tranylcypromine [eg, Parnate]) or Tricyclic antidepressants (amitriptyline [eg, ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Diphenoxylate and Atropine (Systemic).  -  Jul 28, 2005
Furoxone], isocarboxazid [eg, Marplan], phenelzine [eg, Nardil], procarbazine [eg, Matulane], selegiline [eg, Eldepryl], tranylcypromine [eg, ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Sibutramine (Systemic).(Drug overview)  -  Aug 1, 2006
...and is not recommended Monoamine oxidase (MAO) inhibitor activity (isocarboxazid [eg, Marplan], phenelzine [eg, Nardil], procarbazine [eg, Matulane], ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Escitalopram (Systemic).(Drug overview)  -  Aug 1, 2006
Zyvox) or Monoamine oxidase (MAO) inhibitor activity (isocarboxazid [eg, Marplan], phenelzine [eg, Nardil], procarbazine [eg, Matulane], selegiline [eg, ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

How to take Isocarboxazid from Consumer Reports Health.  -  Jan 8, 2007
...methylphenidate (Concerta, Metadate, Ritalin, others); other MAOIs such as phenelzine (Nardil), procarbazine (Matulane), tranylcypromine (Parnate), ... consumerreports.org

Entacapone (Systemic).  -  Jul 28, 2005
Monoamine oxidase (MAO) inhibitors (furazolidone [eg, Furoxone]. isocarboxazid [eg, Marplan], phenelzine [eg, Nardil], procarbazine [eg, Matulane], ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Ephedra.(Drug overview)  -  Feb 1, 2007
Procarbazine * Pseudoephedrine (found in many cough and cold formulas like Sudafed(R)) * Sodium bicarbonate * Theophylline Warnings: * If you use ephedra, ... Free with registration - AltCareDex Alternative Medicines - AccessMyLibrary.com

Difenoxin and Atropine (Systemic).  -  Aug 1, 2006
...isocarboxazid [eg, Marplan], phenelzine [eg, Nardil], procarbazine [eg, Matulane], tranylcypromine [eg, Parnate]) -- Taking difenoxin and atropine while ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Modafinil (Systemic).(Provigil drug overview)(Central nervous system ...  -  Aug 1, 2006
Marplan], phenelzine [eg, Nardil], procarbazine [eg, Matulane], selegiline [eg, Eldepryl], tranylcypromine [eg, Parnate]) -- These medicines can cause ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Appetite Suppressants, Sympathomimetic (Systemic ).  -  Jul 28, 2005
Marplan], isocarboxazid [e.g., Marplan], phenelzine [e.g., Nardil], procarbazine [e.g., Matulane], selegiline [e.g., Eldepryl], tranylcypromine [e.g., ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Rizatriptan (Systemic).  -  Oct 27, 2005
Marplan], phenelzine [eg, Nardil], procarbazine [eg, Matulane], selegiline [eg, Eldepryl], tranylcypromine [eg, Parnate]) -- Taking rizatriptan while ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Venlafaxine (Systemic).  -  Aug 1, 2006
...and is not recommended Monoamine oxidase (MAO) inhibitor activity (isocarboxazid [eg, Marplan], phenelzine [eg, Nardil], procarbazine [eg, Matulane], ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

This medicine is available only with your doctor's prescription, in...  -  Jul 28, 2005
Monoamine oxidase (MAO) inhibitor activity (isocarboxazid [eg, Marplan], phenelzine [eg, Nardil], procarbazine [eg, Matulane], selegiline [eg, Eldepryl], ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Fexofenadine and Pseudoephedrine (Systemic ).(Drug overview)  -  May 1, 2006
Monoamine oxidase (MAO) inhibitor activity (isocarboxazid [eg, Marplan], phenelzine [eg, Nardil], procarbazine [eg, Matulane], selegiline [eg, Eldepryl], ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

WHO expert committee on specifications for pharmaceutical preparations...  -  Aug 1, 2005
192156 9930398 procaine hydrochloride 100mg 183119 9930399 procarbazine hydrochloride 100mg 184120 9930400 progesterone 100mg 167033 9930402 propranolol ... Free with registration - Technical Report Series - AccessMyLibrary.com

Atomoxetine (Systemic).  -  Feb 1, 2006
Monoamine oxidase (MAO) inhibitor activity (isocarboxazid [eg, Marplan], phenelzine [eg, Nardil], procarbazine [eg, Matulane], selegiline [eg, Eldepryl], ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Antihistamines (Systemic).(Drug overview)  -  May 1, 2006
Marplan], phenelzine [eg, Nardil], procarbazine [eg, Matulane], selegiline [eg, Eldepryl], tranylcypromine [eg, Parnate]) -- If you are now taking, ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

How to take Morphine Oral from Consumer Reports Health.  -  Jan 4, 2006
...(MAO) inhibitors, including isocarboxazid (Marplan), phenelzine (Nardil), procarbazine (Matulane), selegiline (Eldepryl), and tranylcypromine (Parnate). ... consumerreports.org

Escitalopram (Systemic).  -  Jul 28, 2005
Zyvox) or Monoamine oxidase (MAO) inhibitor activity (isocarboxazid [eg, Marplan], phenelzine [eg, Nardil], procarbazine [eg, Matulane], selegiline [eg, ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Type of treatment for recurrent dmay affect survival.(RESEARCH …  -  Nov 1, 2006
The regimen was procarbazine, 1-(2-chloroethyl)-3 cyclohexyl-1-nitrosurea (CCNU), and vincristine (PCV). All patients had radiation therapy; ... Free with registration - Oncology Nursing Forum - AccessMyLibrary.com

Sibutramine (Systemic).  -  Feb 1, 2006
...and is not recommended Monoamine oxidase (MAO) inhibitor activity (isocarboxazid [eg, Marplan], phenelzine [eg, Nardil], procarbazine [eg, Matulane], ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Chemo Plus Involved-Field Radiation Best for Early Hodgkin"s Disease  -  Nov 8, 2007
Chemotherapy consisted of MOPP-ABV (mechlorethamine, vincristine, procarbazine, prednisone -- doxorubicin, bleomycin and vinblastine). ... Cancerpage.com

Antidepressants, Tricyclic (Systemic).(Drug overview)  -  Aug 1, 2006
Marplan], isocarboxazid [e.g., Marplan], phenelzine [e.g., Nardil], procarbazine [e.g., Matulane], selegiline [e.g., Eldepryl], tranylcypromine [e.g., ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Desloratadine and Pseudoephedrine ( Systemic).  -  Feb 1, 2006
Monoamine oxidase inhibitor (MAO) (isocarboxazid [eg, Marplan], phenelzine [eg, Nardil], procarbazine [eg, Matulane], selegiline [eg, Eldepryl], ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Methylphenidate (Systemic).(Drug overview)  -  Aug 1, 2006
...phenelzine [eg, Nardil], procarbazine [eg, Matulane], selegiline [eg, Eldepryl], tranylcypromine [eg, Parnate]) -- Taking methylphenidate while you are ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Appetite Suppressants, Sympathomimetic (Systemic ).  -  Aug 1, 2006
Marplan], isocarboxazid [e.g., Marplan], phenelzine [e.g., Nardil], procarbazine [e.g., Matulane], selegiline [e.g., Eldepryl], tranylcypromine [e.g., ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Causes of Leukemia  -  May 4, 2007
The chemotherapeutic agents most often associated with secondary leukemias are procarbazine, chlorambucil, etoposide, mechlorethamine, teniposide, ... Buzzle

Buspirone (Systemic).  -  Oct 27, 2005
Marplan], phenelzine [eg, Nardil], procarbazine [eg, Matulane], selegiline at doses more than 10 mg a day [eg, Eldepryl], tranylcypromine [eg, ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Using Molecular Information to Guide Brain Tumor Therapy  -  Jun 2, 2006
...and others demonstrated that anaplastic oligodendroglioma patients who have tumors bearing chromosome 1p loss almost always respond to procarbazine, ... Medscape

Systemic Adjuvant Therapy for Patients With High-Risk Melanoma  -  Nov 10, 2006
Among the agents studied were dacarbazine, vinblastine, vincristine, thiotepa, rufocromycin, methotrexate, procarbazine, carmustine, hydroxyurea, ... Archives of Dermatology

Controlled (S8)(AU) Class A(UK) Schedule II(US)  -  Aug 1, 2006
Pethidine has serious interactions that can be dangerous with MAOIs (eg furazolidone, isocarboxazid, moclobemide, phenelzine, procarbazine, selegiline, ... chemie.de

International Approvals: Temodal, Xolair, Macugen  -  Jun 13, 2005
...with refractory anaplastic astrocytoma who experienced disease progression while receiving a drug regimen containing nitrosurea and procarbazine. ... Medscape

Differential Chemosensitivity of Tumor Components in a Malignant …  -  Nov 1, 2005
...man who underwent diffusion-weighted, perfusion-weighted, and volumetric MR imaging before and after PCV (procarbazine, CCNU, vincristine) chemotherapy. ... AJNR (subscription)

Fentanyl (Systemic).  -  Jul 28, 2005
Monoamine oxidase (MAO) inhibitor activity (isocarboxazid [eg, Marplan], phenelzine [eg, Nardil], procarbazine [eg, Matulane], selegiline [eg, Eldepryl], ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Sertraline (Systemic).  -  Feb 1, 2006
Marplan], phenelzine [eg, Nardil], procarbazine [eg, Matulane], selegiline [eg, Eldepryl], tranylcypromine [eg, Parnate]) -- ( Do not take sertraline ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Brand Names/Synonyms:
Procarbazine is also known by the following brand names and/or synonymsCCRIS 2389; CHEMBANK3199; HSDB 3250; IBZ; Ibenzmethyzin; Ibenzmethyzine; Ibenzmethyzine Hydrochloride; MBH; MIH; Matulane; Mih Hydrochloride; NSC-77213; Nathulane; Natulan; Natulan Hydrochloride; Natulanar; Natunalar; PCB; PCX; Pcb Hydrochloride; Procarbazin; Procarbazin [German]; Procarbazina [Inn-Spanish]; Procarbazine; Procarbazine Hydrochloride; Procarbazinum [Inn-Latin]; Ro 4 6467/1

Drug Category:
Procarbazine is categorized under the following by the FDA: Antineoplastic Agents; ATC:L01XB01

Dosage Forms:
CAPSULE

Absorption:
Procarbazine is rapidly and completely absorbed.

Interactions:
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Chemical IUPAC Name:
N-(1-methylethyl)-4-[(N'-methylhydrazino)methyl]benzamide





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