Prograf

This page contains recent news articles, when available, and an overview of Prograf but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Prograf
(when available)

Pharmacology and use:
Tacrolimus, a macrolide immunosuppressant produced by Streptomyces tsukubaensis, is an immunosuppressive agent indicated for the treatment of patients receiving kidney and/or liver transplants. Tacrolimus has been demonstrated to suppress humoral immunity and, to a greater extent, cell-mediated reactions such as allograft rejection, delayed type hypersensitivity, collagen- induced arthritis, experimental allergic encephalomyelitis, and graft versus host disease. It has similar immunosuppressive properties to cyclosporine, but is much more potent in equal volumes. Tacrolimus is indicated for the prophylaxis of organ rejection in patients receiving allogeneic liver or kidney transplants. Used in a topical preparation in the treatment of severe atopic dermatitis, also used after bone marrow transplants and for severe refractory uveitis.

Mechanism Of Action:
Tacrolimus inhibits T-lymphocyte activation by first binding to an intracellular protein, FKBP-12. A complex of Tacrolimus-FKBP-12, calcium, calmodulin, and calcineurin is then formed and the phosphatase activity of calcineurin is inhibited. This prevents the dephosphorylation and translocation of nuclear factor of activated T-cells (NF-AT), a nuclear component thought to initiate gene transcription for the formation of lymphokines. Tacrolimus also inhibits the transcription for genes which encode IL-3, IL-4, IL-5, GM-CSF, and TNF-, all of which are involved in the early stages of T-cell activation. Additionally, Tacrolimus has been shown to inhibit the release of pre-formed mediators from skin mast cells and basophils, and to downregulate the expression of FceRI on Langerhans cells.

News Articles on Tacrolimus

Astellas Wins Approval for Overactive Bladder Treatment in China  -  ‎Dec 22, 2009‎
In 2008, Astellas China's revenues were about $100 million, led by its flagship product, Prograf, an immunosuppressant used to prevent rejection of ... Seeking Alpha (blog)

LifeCycle Pharma submits Phase 3 Protocol for LCP-Tacro to FDA  -  ‎Dec 23, 2009‎
De novo kidney transplant candidates areAexpected to be randomized to receive either LCP-Tacro or Prograf following their kidney transplantation, ... Trading Markets (press release)

LFP-Geschäft soll weiter wachsen  -  ‎Dec 17, 2009‎
...(dmnet) Insbesondere im dritten Quartal habe das Unternehmen gute Verkaufszahlen bei Rollensystemen aus der Image Prograf-Serie erreicht. ... Druck-Medien.net

中化æ?¶æ?­å…?疫抑制劑商機  -  ‎Dec 29, 2009‎
...塔克莫å?¸è—¥ç‰©åŽŸå» ç‚ºæ—¥æœ¬é˜¿æ–¯ç‰¹æ‹‰æ–¯ï¼ˆAstella Pharma Prograf),該藥物為全ç?ƒæœ€ä¸»è¦?的器官移æ¤?抗排斥用藥,已行銷全ç?ƒ80多個國家和地å?€ï¼ŒåŽ»å¹´éŠ·å”®é¡?716億元,今年åˆ?ä¼° ... 中時電子報

Hikma 3Q Sales Slow; Western JV Within Months  -  ‎Nov 12, 2009‎
Advagraf is a newer version of a drug called Prograf. Noble analyst Stefan Hamill said in a research note the licensing deal is significant because he ... Wall Street Journal

Astellas Pharma set to launch Prograf in India, works on marketing strategy  -  ‎Nov 12, 2009‎
Prograf, the world's best-selling drug used to stop transplanted organs from being rejected, is planned to be commercialised in the country by the first ... pharmabiz.com

Astellas Cuts Annual Profit Outlook on Yen, Charges  -  ‎Nov 4, 2009‎
...“Given the current situation of Prograf sales, the company probably can't help but be conservative about its forecasts.� Astellas projects research and ... Bloomberg

Astellas counts the cost of Prograf generic  -  ‎Nov 6, 2009‎
Sales edged up 0.3% to 494.64 billion yen, driven by Prograf (tacrolimus). However sales of the drug were down 1.3% to 103.00 billion yen, as Novartis unit ... Pharma Times

New Canon showroom tipped as UK's largest  -  ‎Nov 12, 2009‎
The new showroom will display all Canon's large-format Image PROGRAF line-up, as well as the C1+, a new light-production printer. There is also a boardroom ... CRN - UK

Astellas wins Japanese approval for additional indication of Prograf  -  ‎Oct 19, 2009‎
Prograf has already been approved for 'myasthenia gravis in a case where the effect of steroids is insufficient or administration of steroids is difficult ... Trading Markets (press release)

India is hot for mid-size pharma, too  -  ‎Nov 6, 2009‎
Japan's Astellas Pharma is now recruiting sales execs for the launch of its first product in India, its flagship transplant drug Prograf, which is running ... FiercePharma

LifeCycle Pharma Announces Result for the First Nine Months of 2009 and ...  -  ‎Nov 12, 2009‎
...phase of the study to have a potential best-in-class profile when compared to the currently marketed twice daily tacrolimus capsule, Prograf(R). ... Benzinga

Astellas Pharma Inc. - SWOT Analysis - research report released  -  ‎Oct 26, 2009‎
The increase in revenues during FY2008 was mainly due to the expanded global sales of Prograf and Vesicare. The operating profit of the company was JPY275 ... PR-Inside.com (Pressemitteilung)

LEAD: Tokyo stocks fall on losses in financial, resource shares  -  ‎Oct 27, 2009‎
Barclays Capital downgraded the drugmaker's investment rating on its loss in market share for the immune system drug Prograf. ... istockAnalyst.com (press release)

Commercial Insight - Solid organ transplantation - The impact of new biologics ...  -  ‎Oct 23, 2009‎
However, the combined sales of Astellas´s tacrolimus franchise (Prograf and once-daily Advagraf) will dominate the immunosuppressant market over the next ... PR-Inside.com (Pressemitteilung)

Astellas licenses Medivation's prostate cancer candidate  -  ‎Oct 28, 2009‎
...by analysts at Barclays Capital to "underweight" from "equal weight", on the basis of generic competition to its transplant drug Prograf (tacrolimus). ... Pharma Times

India is growth tonic for mid-tier global pharma  -  ‎Nov 1, 2009‎
Astellas is now recruiting sales executives to launch its first product in India, its $2 billion flagship brand Prograf, used to prevent rejection in organ ... Rediff

Ironwood and Astellas Announce Japan Licensing Agreement for Linaclotide  -  ‎Nov 9, 2009‎
Astellas has discovered an over-active bladder (OAB) medication, Vesicare® and an immunosuppressive agent, Prograf® (tacrolimus), which have enabled them to ... SYS-CON Media (press release)

PRESS RELEASE: Novartis Delivers Strong New -3-  -  ‎Oct 21, 2009‎
...consecutive quarter in 2009 of year-on-year growth thanks to new product launches, including a first-to-market launch of generic tacrolimus (Prograf®). ... Capital.gr (press release)

Novartis T3: performance hétérogène divisions non pharma - Sandoz en bonne voie  -  ‎Oct 21, 2009‎
...pour le deuxième trimestre d'affilée, une croissance, comparé aux mêmes trimestres de 2008, grâce au lancement de nouveaux produits, comprenant Prograf, ... Romandie.com

æ—¥ 제네릭 시장 '외ìž?사 진출러시'  -  ‎Nov 2, 2009‎
...ìš°ì„  ë‚´ë…„ì—? '노보믹스'(NovoMix, insulin aspart), '악토넬'(Actonel, risedronate), '세레벤트'(Serevent, salmeterol), '프로그ëž?'(Prograf, tacrolimus)ì?˜ 특허가 ... 디지틀보사

Literatüre geçti ama ilacını alamıyor  -  ‎Oct 26, 2009‎
Biri (Rapamone) 876 diğeri (Prograf) 176 lira� dedi. Nakil ekibinden Opr. Dr. Selçuk Kılınç da ilaç sorununun, ince bağırsak naklinin böbrek, ... Star Gazete

Literatüre geçti ama ilaç engelini geçemedi  -  ‎Oct 26, 2009‎
Biri (Rapamone) 876, diğeri (Prograf) 176 lira. Devlet bunu karşılamıyor. Eşim SSK emeklisi. Ne yapıp edip ilaçları alıyoruz, ama nereye kadar? ... Milliyet

Gel de yaÅŸa  -  ‎Oct 25, 2009‎
Biri (Rapamone) 876 diÄŸeri (prograf) 176 lira. Ancak devlet bunu karşılamıyor. İnce barsak nakilli yaÅŸayan ilk ve tek hastayım ama bu ÅŸartlarda gel de yaÅŸa. ... Hürriyet

La concentración de medios y sus implicaciones políticas, éticas y económicas ...  -  ‎Oct 29, 2009‎
La empresa PROGRAF SA Adicionalmente posee participaciones minoritarias en el Diario El Comercio y en EDIMPRES controlados por el Grupo Mantilla. ... argenpress.info

DJ HUGIN NEWS/Novartis verzeichnet in den ersten -6-  -  ‎Oct 21, 2009‎
Dazu gehörte unter anderem die erste Markteinführung einer generischen Version von Tacrolimus (Prograf®). In Mittel- und Osteuropa wurden kräftige Zuwächse ... unternehmer.de

Astellas Profit Rises 5.1% on Prograf, Vesicare Drugs  -  Aug 1, 2008
By Kanoko Matsuyama. Aug. 1 (Bloomberg) -- Astellas Pharma Inc., Japan's second- largest drugmaker, said first-quarter profit rose 5.1 percent, ... Bloomberg

Astellas' Daily Prograf Moves Closer to US Approval  -  Mar 14, 2008
By Jason Gale. March 14 (Bloomberg) -- Astellas Pharma Inc., Japan's second-largest drugmaker, moved closer to gaining US approval for a once-daily version ... Bloomberg

Astellas: US FDA seeks more data on Prograf uses  -  Mar 20, 2007
TOKYO, March 20 (Reuters) - Astellas Pharma Inc. (4503.T), Japan's third-largest drug maker, said on Tuesday that US authorities have said they could not ... Reuters

Astellas Third-Quarter Profit Rises 13% on Prograf, Vesicare  -  Feb 1, 2007
By Hiroshi Suzuki. Feb. 1 (Bloomberg) -- Astellas Pharma Inc., Japan's third- largest drugmaker, reported third-quarter profit rose 13 percent on higher ... Bloomberg

… Studies Demonstrate Once-Daily Modified Release Prograf(R) Formula...  -  May 24, 2005
SEATTLE, May 24 /PRNewswire/ -- Two studies presented today at the 6th American Transplant Congress (ATC) demonstrate the safety and efficacy of once-daily ... RedOrbit

Astellas Pharma Raises Profit Target on Tax Rate, Prograf Sales  -  Feb 1, 2008
By Kanoko Matsuyama. Feb. 1 (Bloomberg) -- Astellas Pharma Inc., Japan's second- largest drugmaker, raised its full-year profit forecast by 33 percent on ... Bloomberg

Astellas once-daily Prograf gets EU recommendation  -  Feb 25, 2007
TOKYO, Feb 26 (Reuters) - Astellas Pharma Inc. (4503.T), Japan's third-largest drug maker, said on Monday a committee of the European Medicines Agency had ... Reuters UK

Astellas Receives FDA Approval of Prograf(R) (Tacrolimus) for Use in ...  -  Mar 31, 2006
DEERFIELD, Ill., March 31 /PRNewswire/ -- The Food and Drug Administration (FDA) has granted Astellas Pharma US, Inc. approval for the use of Prograf as an ... RedOrbit

Astellas: US not ready to approve transplant drug  -  May 7, 2008
Astellas is keen to gain approval for Advagraf, a modified release version of transplant drug Prograf, which brings in some $2 billion in annual sales but ... Reuters

… Once-a-Day Prograf MR(TM) (Modified Release) and Twice-Daily Progra...  -  Jul 26, 2006
BOSTON, July 26 /PRNewswire/ -- Study results presented today at the World Transplant Congress (WTC) demonstrated that investigational drug, ... RedOrbit

Astellas gets EU go for once-daily transplant drug  -  Apr 27, 2007
The new formulation is a modified release version of Prograf, which is used to prevent organ rejection and is currently given twice a day. ... Reuters

LifeCycle Pharma starts head-to-head study of LCP-Tacro vs Astellas' ...  -  Sep 5, 2007
Advagraf, which is once-a-day version of Astellas' Prograf, is used in renal transplants in Germany and the UK. The clinical trial will enrol 24 healthy ... Forbes

Prograf gets FDA OK for heart transplant care.(Brief article)  -  Apr 3, 2006
The US Food and Drug Administration says it has approved Japanese drugmaker Astellas Pharma's immunosuppressant Prograf (tacrolimus hydrate) for the ... Free with registration - Pharma Marketletter - AccessMyLibrary.com

Astellas wins Japan approval for new transplant drug  -  Jul 17, 2008
Prograf brings in some $2 billion in annual sales but lost US patent protection earlier this year. The US Food and Drug Administration declined in January ... Reuters

Astellas posts strong Q1, trims European operations  -  Aug 1, 2007
Sales of Prograf and Advagraf, used to prevent organ rejection in ... The US patent on Astellas' twice-daily version of Prograf runs out in 2008, ... Reuters

… Once-a-Day Prograf MR(TM) (Modified Release) And Twice-Daily Prograf...  -  Jul 27, 2006
Study results presented today at the World Transplant Congress (WTC) demonstrated that investigational drug, once-daily Prograf MR(TM) (Modified Release) ... Medical News Today - Medical News Today (press release)

Nikkei down 1.7 pct as exporters, property firms hit  -  Apr 9, 2008
T: Quote, Profile, Research) fell 3.5 percent to 4150 yen, one day after it lost US patent protection on transplant drug Prograf amid worries that its ... Reuters UK

Astellas Bets on New Prograf Drug to Thwart Generics  -  Aug 23, 2007
By Kanoko Matsuyama and Yuki Hagiwara. Aug. 23 (Bloomberg) -- Astellas Pharma Inc., Japan's second-largest drugmaker, is counting on a new formulation of ... Bloomberg

… Obtains Additional Approval for Its Immunosuppressant Drug Prograf  -  Apr 11, 2005
Prograf capsules is now available for the treatment of rheumatoid arthritis ... Released in June 1993, Prograf has been widely used for the prophylaxis of ... japancorp.net

Astellas faces FDA delay on reformulated Prograf  -  Jan 23, 2007
The FDA has issued a nonapprovable letter to Japan's Astellas Pharma for a new formulation of its drug Prograf for heart transplant patients. ... FierceBiotech

… Release: Astellas Receives FDA Approval of Prograf(R) (Tacrolimus)...  -  Mar 31, 2006
Astellas Receives FDA Approval of Prograf(R) (Tacrolimus) for Use in Heart Transplant Recipients. from PR Newswire. Highbeam Research – FREE Trial. Pay-Per-View - PR Newswire - HighBeam Research

Lifecycle Pharma posts positive data for organ rejection treatment …  -  Mar 3, 2008
...'The results are a very important milestone for LCP and demonstrate LCP-Tacro's potential advantages over (competing treatment) Prograf,' Lifecycle Pharma's ... Forbes

International Approvals: Follistim, Tracleer, Prograf  -  Apr 18, 2005
April 18, 2005 — The Japanese Ministry of Health, Labor, and Welfare has approved use of recombinant follicle-stimulating hormone injection for controlled ... Medscape

Article: Astellas Pharma US receives FDA approval of Prograf for use...  -  Apr 17, 2006
Astellas Pharma US receives FDA approval of Prograf for use in heart transplant recipients.(United States)(Food and Drug Administration)(Brief article) ... Pay-Per-View - Transplant News - HighBeam Research

Pfizer, Astellas settle Lipitor sales disagreement  -  Jan 26, 2007
Astellas shares gained ground on Friday, closing up 1.4 percent at 5120 yen, but are still 4 percent lower than levels prior to the Prograf news. ... Reuters

Astellas Moves Closer to Gaining FDA Approval for Daily Prograf  -  Mar 14, 2008
By Jason Gale. March 14 (Bloomberg) -- Astellas Pharma Inc., Japan's second-largest drugmaker, moved closer to gaining US approval for a once-daily version ... Bloomberg

Astellas Pharma US receives FDA approval of Prograf for use in heart ...  -  Apr 17, 2006
Astellas Pharma US receives FDA approval of Prograf for use in heart transplant recipients. Astellas Pharma US, Inc., Deerfield, IL, has received approval ... $9.94 - Transplant News - Alacra Store

Day 1, Part 1: On the Run  -  May 18, 2005
These two machines come with software that may well make the two Prograf printers the ... The hard costs--consumables--for the Prograf line vary with the ... What They Think

Lifecycle Pharma says transplant treatment successful in clinical...  -  Nov 7, 2007
...to demonstrate LCP-Tacro's superiority to both Advagraf and (competing treatment) Prograf,' said Lifecycle Pharma chief executive Flemming Orskov. Forbes

… : Once-Daily MR (Modified Release) Prograf(R) Formulation Shown to ...  -  Jul 26, 2006
Once-Daily MR (Modified Release) Prograf(R) Formulation Shown to Have Equivalent Efficacy and Safety to Twice-Daily Prograf(R) or Neoral(R) in Kidney ... Pay-Per-View - PR Newswire Europe - HighBeam Research

Astellas Shares Rise to 2008 High on Profit Outlook  -  Aug 4, 2008
...``Development of a generic version of Prograf has been delayed.'' Nakazawa rates Astellas ``outperform.'' The drugmaker expects net income of 159 billion ... Bloomberg

Astellas First-Half Profit Jumps 47% on Prograf Sales  -  Nov 6, 2007
By Kanoko Matsuyama. Nov. 6 (Bloomberg) -- Astellas Pharma Inc., Japan's second- largest drugmaker, had a 47 percent jump in first-half profit, ... Bloomberg

Senior Program .Senior Prograf .  -  May 1, 2005
Banner Bonk Is seeking Retail Branch Manager for our Kennewick Branch. This position will load a retail branch lo ensure exceptional customer service, ... Tri City Herald - Google News Archive

… : Phase III Study Demonstrates Once-a-Day Prograf MR(TM) (Modified ...  -  Jul 26, 2006
Phase III Study Demonstrates Once-a-Day Prograf MR(TM) (Modified Release) and Twice-Daily Prograf(R) Are as Effective as Neoral(R) in Kidney Transplant ... Pay-Per-View - PR Newswire - HighBeam Research

LifeCycle Pharma Announces Positive Topline Results From Phase II …  -  Jul 9, 2008
Pharmacokinetic assessment was performed on Day 7 (Prograf®) and Day 14 & 21 (LCP-Tacro). On Day 22, patients were offered to enroll in the 52-week ... Medical News Today - Medical News Today (press release)

Astellas' Prograf approved for rheumatoid arthritis.(Astellas...  -  Apr 18, 2005
Astellas Pharma has received Japanese approval for its immunosuppressant Prograf (tacrolimus hydrate) in rheumatoid arthritis. The 5mg and 10mg capsules ... $4.95 - Pharma Marketletter - ECNext

Press Release: FDA approves Prograf to prevent rejection of heart …  -  Mar 31, 2006
FDA approves Prograf to prevent rejection of heart transplant. from M2 Presswire. Highbeam Research – FREE Trial. Pay-Per-View - M2 Presswire - HighBeam Research

Order Prograf Without Prescription  -  Jul 16, 2007
The following is a partial list of North American universities that offer a Order Prograf Without Prescription in pharmacology or in related disciplines. ... Sokwanele

FDA CAPSULES  -  Apr 11, 2006
PROGRAF APPROVED TO PREVENT REJECTION OF HEART TRANSPLANT. Prograf, a drug that suppresses the body's immune system to help prevent organ rejection in heart ... Pay-Per-View - Newsday - ProQuest Archiver

Prograf COD  -  Aug 2, 2007
...are typically produced by pharmaceutical companies may do a number of things:[2] * Carefully research the demand for their potential Prograf COD product ... Sokwanele

Astellas Pharma's Prograf receives add'l indication for RA.  -  Apr 25, 2005
Prograf is an Astellas product with active ingredient tacrolimus approved as an immunosuppressant. The company has now received approval for the additional ... Pay-Per-View - Pharma Japan - Factiva, from Dow Jones

Prograf Digital Service Expands Field Service Solutions  -  Jul 23, 2008
COVINGTON, KY – JULY 22, 2008 – Prograf Digital Service, a leading provider of exceptional service experiences, printing equipment and supplies, ... What They Think

Discount Prograf Without Prescription  -  Sep 8, 2007
...and they enforce standards set by the European Discount Prograf Without Prescription the main body that regulates pharmaceuticals Discount Prograf Without ... Sokwanele

Transplant Medicine; US FDA approves Prograf to prevent rejection of ...  -  May 3, 2006
2006 MAY 3 - (NewsRx.com) -- The US Food and Drug Administration (FDA) approved Prograf (tacrolimus), a drug that suppresses the body's immune reaction, ... Pay-Per-View - Immunotherapy Weekly - Factiva, from Dow Jones

LifeCycle Pharma Moves LCP-Tacroâ„¢ into Clinical Phase 3  -  Dec 29, 2008
Management of tacrolimus levels is complicated by the low bioavailability of Prograf®, its variable absorption and interaction with food and other drugs. ... Genetic Engineering News - Genetic Engineering News (press release)

Order Prograf COD  -  Dec 10, 2007
This development phase can take up to 6 years the new medicine Order Prograf COD other companies from producing that medicine for a certain allocation of ... Sokwanele

Discount Prograf Online  -  Jul 10, 2007
...field of medication is a vital concern to medicine, but also has strong economical and political implications. To protect the consumer and prevent abuse, ... Sokwanele

Generic Prograf  -  May 12, 2007
Molecular and Generic Prograf study of mind, brain and drugs. * Neuropharmacology - The Molecular and Behavior study of chemicals requires intimate ... Sokwanele

Prograf 240 Pills X 1 Mg  -  Jun 9, 2007
United States, the Food and Drug Administration and they enforce standards set by the federal Prescription Drug Marketing Act (PDMA) * Psychopharmacology ... Sokwanele

Transplant Medicine; US FDA approves Prograf to prevent rejection of ...  -  May 5, 2006
2006 MAY 5 - (NewsRx.com) -- The US Food and Drug Administration (FDA) approved Prograf (tacrolimus), a drug that suppresses the body's immune reaction, ... Pay-Per-View - Drug Week - Factiva, from Dow Jones

TAKEDA, FUJISAWA ONLY BIG JAPAN DRUGMAKERS TO POST …  -  Feb 1, 2005
Fujisawa's revenue, meanwhile, edged up 2 per cent to 323 billion yen, led by solid sales of its Prograf immunosuppressant. Sankyo Co. ... $4.95 - AsiaPulse News - ECNext

Prograf Digital Service Launches National Field Service Network  -  Oct 10, 2008
Covington, KY – OCTOBER 8, 2008 – Prograf Digital Service (PDS), a leading provider of exceptional service experiences, printing equipment and supplies, ... What They Think

Press Release: Prograf Now Approved for Prophylaxis Use in Heart …  -  Apr 21, 2006
Prograf Now Approved for Prophylaxis Use in Heart Transplantation Across Europe. from PR Newswire Europe. Highbeam Research – FREE Trial. Pay-Per-View - PR Newswire Europe - HighBeam Research

Astellas Pharma's Immunosuppressant Prograf Now Available in Europe.  -  Apr 25, 2006
Tokyo, Japan, Apr 24, 2006 - (JCN) - Astellas Pharma recently announced the European Commission's approval of the Company's proprietary immunosuppressant ... Free with registration - JCNN News Summaries - AccessMyLibrary.com

Canon's image Prograf Large Format Printers Honored By Bertl, Inc.  -  Jun 11, 2008
Canon USA, Inc., a leading provider of office imaging systems, inkjet technology and digital photography equipment, today announced its imagePROGRAF iPF710, ... webwire.com

… helps prevent heart transplant rejection.(Prograf from Astellas...  -  Jul 1, 2006
A new drug that suppresses the body's immune reaction for the prevention of graft rejection in heart transplant recipients has been approved by the FDA. ... $4.95 - FDA Consumer - ECNext

… Release: Kidney Transplant Patients Treated With Prograf(R) Show...  -  Jul 25, 2006
Kidney Transplant Patients Treated With Prograf(R) Show Better Renal and Lipid Responses Compared With Neoral(R). from PR Newswire Europe. Pay-Per-View - PR Newswire Europe - HighBeam Research

International Approvals: Omnitrope, Prograf, Cetrotide  -  May 1, 2006
May 1, 2006 — The European Commission has approved a generic formulation of somatropin for use as long-term replacement therapy in children and adults, ... Medscape

TradeName : Pangraf, Vingraf, Prograf, Protopic, Tacromus  -  Dec 31, 2008
Why it is prescribed (Indications) : Tacrolimus is used to prevent rejection of Kidney, Heart and Liver Transplanted organ . It is also used for treatment ... MedIndia

Hepatitis C Infection Raises Diabetes Risk After Liver Transplants  -  Jan 8, 2007
8 -- Liver transplant recipients who are hepatitis C-virus (HCV) positive and receive Prograf (tacrolimus) as part of their immunosuppressant regimen are at ... MedPage Today

LifeCycle Pharma Initiates Phase II Clinical Trial for LCP-Tacro, an ...  -  Dec 3, 2007
Management of tacrolimus levels is complicated by the low bioavailability of Prograf, its variable absorption and interaction with food and other drugs. ... Genetic Engineering News - Genetic Engineering News (press release)

Positive kidney transplant data for Atellas' Prograf.  -  Jul 31, 2006
Positive kidney transplant data for Atellas' Prograf. Japanese drug major Astellas has reported new data showing that after only six months post-conversion ... $9.94 - Pharma Marketletter - Alacra Store

FDA APPROVES ASTELLAS PHARMA'S PROGRAF TO TREAT HEART …  -  Apr 25, 2006
The US FDA has approved Japanese drugmaker Astellas Pharma's Prograf -- a drug that suppresses the body's immune response -- for the prevention of graft ... Pay-Per-View - Daily International Pharma Alert - Factiva, from Dow Jones

PROGRAF APPROVED TO PREVENT HEART TRANSPLANT …  -  Apr 11, 2006
The FDA has approved Astellas Pharma's Prograf -- a drug that suppresses the body's immune response -- for the prevention of graft rejection in heart ... Pay-Per-View - FDAnews Drug Daily Bulletin - Factiva, from Dow Jones

Once-a-Day or Twice-Daily Tacrolimus as Effective as Cyclosporine in ...  -  Aug 3, 2006
Prograf MR is a modified release version of the FDA-approved twice-daily ... Both formulations of Prograf also showed significantly less treatment failure ... DG News

Astellas' modified Prograf Oked in Japan.  -  Jul 28, 2008
Astellas' modified Prograf Oked in Japan. Japanese drugmaker Astellas has received marketing approval for the immunosuppressant Graceptor (tacrolimus ... $9.94 - Pharma Marketletter - Alacra Store

Japan's Astellas to market new immunosuppressive drug Advagraf in …  -  Jun 18, 2007
Including sales of the popular Prograf, which is the twice-a-day version of Advagraf, the Japanese drugmaker said it targets annual sales of some 190.4 bln ... ABCmoney.co.uk

LifeCycle Pharma Announces Positive Phase I Clinical Results for its ...  -  May 31, 2007
..."The once-daily profile and significant increase in bioavailability, compared to Prograf(R), that has been demonstrated for our LCP-Tacro product candidate ... $4.95 - PR Newswire - ECNext

Cyclosporine Shows Advantage Over Tacrolimus  -  Jan 6, 2006
The most commonly used anti-rejection medication is tacrolimus, brand name Prograf, marketed by Astellas Pharma, although cyclosporine (Sandimmun) produced ... RedOrbit

Article: Post--kidney-transplant Prograf may spur diabetes.(Clinical ...  -  Nov 1, 2006
Post--kidney-transplant Prograf may spur diabetes.(Clinical Rounds) ... find Skin & Allergy News articles. BOSTON -- Use of tacrolimus after kidney ... Pay-Per-View - Skin & Allergy News - HighBeam Research

Infliximab Injection Side Effects from Consumer Reports Health.  -  Jan 4, 2007
Sandimmune), oral corticosteroids; 6-mercaptopurine (Purinethol); methotrexate (Rheumatrex), sirolimus (Rapamune), and tacrolimus (Prograf). ... consumerreports.org

Japan stock market week to October 9, 2006.(forecasts and trends)  -  Oct 16, 2006
The company anticipates a difficult operating environment due to the patent expiration of two of its main drugs, the immunosuppressant Prograf (tacrolimus) ... Free with registration - Pharma Marketletter - AccessMyLibrary.com

Astellas Pharma US, Inc., Deerfield, IL, Aug. 31 (DDMAC).(HUMAN …  -  Sep 1, 2006
Moreover, the ad indicated that Prograf users exhibited a "favorable cardiovascular profile with significantly fewer Prograf-treated patients requiring ... $4.95 - Warning Letter Bulletin - ECNext

Astellas in mid-stage trials of new transplant drug  -  Sep 12, 2007
Astellas has also developed a once-daily version of Prograf, which is currently given twice a day, and which has been approved in Europe. ... Reuters

LifeCycle Pharma Announces Transplantation Programs On Track  -  Jan 22, 2008
Prograf® is currently marketed worldwide by Astellas Pharma as twice-a-day capsules of tacrolimus. These results are consistent with the interim results ... Medical News Today - Medical News Today (press release)

LifeCycle Pharma Announces Transplantation Programs on Track  -  Jan 18, 2008
Prograf(R) is currently marketed worldwide by Astellas Pharma as twice-a-day capsules of tacrolimus. These results are consistent with the interim results ... Genetic Engineering News - Genetic Engineering News (press release)

Long-term stability of a patient-convenient 1 mg/ml suspension of …  -  Mar 6, 2006
Tacrolimus (Prograf ® , FK506, Fujisawa Healthcare) is a widely used ... Tacrolimus (Prograf ® , Fujisawa, Deerfield, IL, USA) suspensions were prepared to ... Nature.com

Study finds low-dose Pharma drug best after transplant  -  Dec 19, 2007
BOSTON (Reuters) - Small doses of Astellas Pharma Inc's Prograf did a better job at preventing rejection of a transplanted kidney than varying doses of ... Reuters

Nuovi plotter Canon per professionisti  -  Sep 9, 2005
Canon ha annunciato l'introduzione di due nuovi sistemi di stampa a largo formato (LPF) con inchiostro a base dye: imagePrograf W8400D e image Prograf ... Punto Informatico

LifeCycle Pharma Announces Positive Interim Phase II Clinical Trial …  -  Oct 26, 2007
Prograf([R]) is currently marketed worldwide by Astellas Pharma as twice-a-day capsules of tacrolimus. "We are pleased with the positive results of this ... $4.95 - Business Wire - ECNext

Justiça determina retorno do fornecimento do Prograf  -  Dec 12, 2008
O juiz da VII Vara da Justiça Federal no Ceará determinou o retorno do fornecimento do remédio Prograf para o tratamento de transplantados. ... Diário do Nordeste - Diário do Nordeste (Assinatura)

COMUNICADO: Prograf recibe la aprobación de uso en Europa para la …  -  Apr 21, 2006
TOKIO y LONDRES, April 21 /PRNewswire/ -- Astellas Pharma Inc. ("Astellas"; sede: Tokio; director general y consejero delegado: Toichi Takenaka) ha ... elEconomista.es

Prograf nun als Prophylaxe bei Herzverpflanzungen in Europa …  -  Apr 21, 2006
Tokio und London (ots/PRNewswire) - Astellas Pharma Inc. ("Astellas"; Firmensitz: Tokio; President und CEO: Toichi Takenaka) kündigte heute an, ... presseportal.de

Astellas' says Advagraf represents step forward in post-transplant …  -  Oct 8, 2007
In terms of safety, Prof Neumayer said that Advagraf and Prograf had demonstrated similar safety profiles, but added that the rate of post-transplant ... $4.95 - Pharma Marketletter - ECNext

Canon steps up presence in CAD, GIS markets  -  Nov 25, 2007
The Image Prograf iPF610 is able to deliver a full colour A1 print on plain ... The Image Prograf iPF710 and iPF610 replace the Image Prograf iPF700 and ... Times of Malta

Tailoring Immunosuppressant Dosages for Each Liver Graft Patient  -  Jun 13, 2005
Immunosuppressants used in the study were Prograf and Sandimmune. ... Sixty-one percent of the group took Prograf as their primary immunosuppressive drug. ... MedPage Today

Bruk av Advagraf og Prograf – risiko for feildosering  -  Dec 19, 2008
Forveksling av doser ved bruk av legemidlene Advagraf og Prograf har ført til alvorlige bivirkninger for pasienter. Det er viktig at helsepersonell er ... Statens legemiddelverk

Продажи препаратов Prograf и Vesicare Ñ?поÑ?обÑ?твовали 52- …  -  Aug 1, 2007
ЯпонÑ?каÑ? фармацевтичеÑ?каÑ? компаниÑ? Astellas Pharma опубликовала 1 июлÑ? финанÑ?овый отчет за I квартал 2008 финанÑ?ового года. Прибыль компании за отчетный ... ФармацевтичеÑ?кий веÑ?тник

ФинанÑ?овые новоÑ?ти архив Ð?а фоне роÑ?та продаж препаратов Progra  -  Feb 1, 2007
Ð’ четверг третьÑ? по величине в Японии фармацевтичеÑ?каÑ? компаниÑ? Astellas Pharma опубликовала финанÑ?овый отчет за III квартал 2007 финанÑ?ового года. ... K2Kapital

Press Release: Sirolimus Reduces the Risk of Cancer in Kidney …  -  Feb 6, 2006
Article: Kidney Transplant Patients Treated With Prograf(R) ... ... Article: Once-Daily MR (Modified Release) Prograf(R) Formulation Shown to ... ... Pay-Per-View - PR Newswire Europe - HighBeam Research

Corte Suprema declara inadmisible recurso en arista de caso MOP Gate  -  Feb 20, 2008
...de Santiago que el 4 de diciembre pasado condenó a los dos acusados a las penas anteriormente indicadas en el proceso también conocido por MOP-Prograf. ... Crónica Concepción

LifeCycle Pharma Announces Positive Phase I Clinical Results for its ...  -  May 30, 2007
..."The once-daily profile and significant increase in bioavailability, compared to Prograf(R), that has been demonstrated for our LCP-Tacro product candidate ... Genetic Engineering News - Genetic Engineering News (press release)

Canon realizó su encuentro de fotografía profesional  -  Nov 29, 2007
Además, durante el encuentro, los profesionales pudieron observar los equipos de impresión, entre los que se encontraban image PROGRAF IPF 5000/17 que ... CanalAR

Lifecycle Pharma klar til fase III med transplantationsmiddel  -  Nov 27, 2008
300 stabile, nyretransplanterede patienter i andet halvår af 2008, hvor patienterne skifter fra Prograf to gange dagligt til LCP-Tacro én gange dagligt med ... UgensErhverv

MOP suma procesados  -  Mar 29, 2006
D'Hainaut García, asesoraba, entre 2001 y 2002, al ex ministro ya la empresa Prograf Impresores limitada. Por otra parte, López Mezquita, dueño de esta ... Diario Renacer de Angol

Press Release: Long Term Sirolimus Data Brings Hope for Kidney …  -  Feb 1, 2005
Article: Primary Therapy with Prograf(R) in Combination with Adjunctive ... ... Article: Kidney Transplant Patients Treated With Prograf(R) ... ... Pay-Per-View - PR Newswire - HighBeam Research

Shigeo Nakanishi und Iwao Yamanaka (Japan)  -  Aug 18, 2008
Das Medikament, welches in über 70 Ländern als Prograf vermarktet wird, ... Die beeindruckende Bilanz von Prograf kann sich sehen lassen: Seit Prograf 1994 ... European Patent Office

Article: Long Term Sirolimus Data Brings Hope for Kidney Transplant …  -  Jan 31, 2005
Article: Primary Therapy with Prograf(R) in Combination with Adjunctive ... ... Article: Kidney Transplant Patients Treated With Prograf(R) ... ... Pay-Per-View - PR Newswire Europe - HighBeam Research

Astellas' fiscal 2007 sales increase 5.6%.  -  Jun 2, 2008
Domestic revenues inched up 0.7% to 505.5 billion yen, with Prograf sales up ... The US patent on Astellas' top earner, Prograf, expires in fiscal 2008 but ... $9.94 - Pharma Marketletter - Alacra Store

Press Release: Aspreva and Roche announce preliminary results for …  -  Jun 27, 2007
Article: Astellas Receives FDA Approval for Use of Prograf(R) (Tacrolimus) . ... Article: Primary Therapy with Prograf(R) in Combination with Adjunctive . ... Pay-Per-View - PR Newswire - HighBeam Research

Brand Names/Synonyms:
Prograf is also known by the following brand names and/or synonymsFK 506; FK-506; FK5; K506; Prograf; Protopic; Tacarolimus; Tacrolimus

Drug Category:
Prograf is categorized under the following by the FDA: Immunosuppressive Agents; ATC:D11AX14; ATC:L04AA05

Dosage Forms:
CAPSULE; OINTMENT; SOLUTION

Absorption:
Generally incomplete with absolute bioavailability of 17-22%

Interactions:
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Chemical IUPAC Name:
[3S-[3R*[E(1S*,3S*,4S*)],4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*]]-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5, 19-dihydroxy-3- [2-(4-hydroxy-3-methoxycyclohexyl) -1-methylethenyl]-14, 16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-15, 19-epoxy-3H-pyrido[2,1-c][1,4] oxaazacyclotricosine-1,7,20, 21(4H,23H)-tetrone, monohydrate





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