Propulsid

This page contains recent news articles, when available, and an overview of Propulsid but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Propulsid
(when available)

Pharmacology and use:
Cisapride is a parasympathomimetic which acts as a serotonin 5-HT4 agonist. Stimulation of the serotonin receptors increases acetylcholine release in the enteric nervous system. Cisapride stimulates motility of the upper gastrointestinal tract without stimulating gastric, biliary, or pancreatic secretions. Cisapride increases the tone and amplitude of gastric (especially antral) contractions, relaxes the pyloric sphincter and the duodenal bulb, and increases peristalsis of the duodenum and jejunum resulting in accelerated gastric emptying and intestinal transit. It increases the resting tone of the lower esophageal sphincter. It has little, if any, effect on the motility of the colon or gallbladder. Cisapride does not induce muscarinic or nicotinic receptor stimulation, nor does it inhibit acetylcholinesterase activity. For the symptomatic treatment of adult patients with nocturnal heartburn due to gastroesophageal reflux disease

Mechanism Of Action:
Cisapride acts through the stimulation of the serotonin 5-HT4 receptors which increases acetylcholine release in the enteric nervous system (specifically the myenteric plexus). This results in increased tone and amplitude of gastric (especially antral) contractions, relaxation of the pyloric sphincter and the duodenal bulb, and increased peristalsis of the duodenum and jejunum resulting in accelerated gastric emptying and intestinal transit.

News Articles on Cisapride

Drug Makers Scrutinized Over Grants  -  Jan 11, 2006
Although Propulsid was approved only to treat severe heartburn in adults, ... The drug was widely prescribed by pediatricians, even though Propulsid was ... New York Times

NYT: J&J, FDA did not warn of heart risks for Propulsid - Jun. 10,...  -  Jun 10, 2005
Drug maker reportedly pushed to keep Propulsid on market despite questions about deaths and use. NEW YORK (CNN/Money) - Drugmaker Johnson & Johnson ... CNNMoney.com

Senators Ask Drug Giant to Explain Grants to Doctors  -  Jul 6, 2005
Johnson & Johnson withdrew Propulsid in 2000 after reports of 80 ... The FDA approved Propulsid in 1993 for the treatment of nighttime heartburn in adults. ... New York Times

Drawing A Bead On Side Effects  -  Apr 11, 2005
Its first target is Propulsid, an acid-reflux treatment that J&J pulled in 2000. It turns out that when patients ingested Propulsid along with certain other ... BusinessWeek

Despite risks, Johnson & Johnson touted heartburn drug ; Only after …  -  Jun 10, 2005
Even though dozens of patients had died and more than 100 had suffered heart problems from the heartburn drug Propulsid by March 1998, federal regulators ... Pay-Per-View - Orlando Sentinel - ProQuest Archiver

Aryx raises $50M in IPO  -  Nov 7, 2007
ATI-7505 is meant to have the same therapeutic benefits as cisapride, a drug sold by Johnson & Johnson (NYSE: JNJ) under the name Propulsid in the United ... Bizjournals.com

… Court Opinions - IN RE PROPULSID PRODUCTS LIABILITY LITIGATION …  -  Feb 17, 2006
IN RE PROPULSID PRODUCTS LIABILITY LITIGATION (EDLa. 2006) IN RE: PROPULSID PRODUCTS LIABILITY LITIGATION. THIS DOCUMENT RELATES TO JILL WALTERS, ... Pay-Per-View - Loislaw Federal District Court Opinions - Loislaw

… Court Opinions - IN RE PROPULSID PRODUCTS LIABILITY LITIGATION …  -  Nov 23, 2005
IN RE PROPULSID PRODUCTS LIABILITY LITIGATION (EDLa. 2005) IN RE: PROPULSID PRODUCTS LIABILITY LITIGATION. THIS DOCUMENT RELATES TO ALL CASES: MDL NO. ... Pay-Per-View - Loislaw Federal District Court Opinions - Loislaw

Attempting to save a drug Another US case of danger played down | …  -  Jun 11, 2005
Propulsid had a good year anyway. Sales continued to surpass $1 billion. Johnson & Johnson continued to underwrite efforts that promoted Propulsid's use in ... Pay-Per-View - International Herald Tribune - HighBeam Research

Article: Heartburn drug use by kids leaps - Chicago Sun-Times | …  -  Oct 5, 2007
Heartburn drug may be dangerous for babies Experts say Propulsid debate shows that ... newspaper ... Propulsid has been linked to 80 deaths since ... ... Pay-Per-View - Chicago Sun-Times - HighBeam Research

… Court Opinions - IN RE PROPULSID PRODUCTS LIABILITY LITIGATION …  -  May 27, 2005
IN RE PROPULSID PRODUCTS LIABILITY LITIGATION (EDLa. 2005) IN RE: PROPULSID PRODUCTS LIABILITY LITIGATION. THIS DOCUMENT RELATES TO ALL CASES. MDL No. ... Pay-Per-View - Loislaw Federal District Court Opinions - Loislaw

Low v. Henry, No. 04-0452 (Tex. 04/20/2007)  -  Apr 20, 2007
Although most of the claims involved the drug Propulsid, some alleged that the ... [35], Undeniably, the petition focuses on Propulsid, a drug used to treat ... $2.95 - Texas Supreme Court - VersusLaw

Federal Panel Consolidates Vioxx Suits  -  Feb 17, 2005
He is overseeing a proposed settlement reached in his court last year for all federal injury claims related to Propulsid, a heartburn drug made by a Johnson ... New York Times

Liability and evidentiary issues involving prescription production...  -  Jan 1, 2007
The defendant in the case entitled In re Propulsid Products Liability ... The Propulsid court began its analysis by reviewing Rule 407's text and its ... $4.95 - Defense Counsel Journal - ECNext

Attempting to Save a Drug Another US Case of Danger Played Down  -  Jun 12, 2005
Propulsid had a good year anyway. Sales continued to surpass $1 billion. ... Members of a US advisory committee on those painkillers cited Propulsid as an ... RedOrbit

Atlanta health, diet and fitness news | ajc.com  -  Jul 6, 2005
But "Johnson & Johnson marketed Propulsid only for its approved indication," he said. Last year, the company agreed to pay up to $90 million to settle ... Atlanta Journal Constitution

… ' Steering Committee and the State Liaison Committee of the Propulsi...  -  Dec 15, 2005
The Propulsid MDL court will post on its website located at ... Committee and State Liaison Committee of the Propulsid Multi-District Litigation ... Free with registration - PR Newswire - AccessMyLibrary.com

Learned-intermediary doctrine rejected in West Virginia.  -  Sep 1, 2007
On May 19, 1999, Nancy Gellner began taking Propulsid to treat acid reflux. ... The FDA approved Propulsid in 1993 to treat heartburn. ... Free with registration - Trial - AccessMyLibrary.com

… and the State Liaison Committee of the PROPULSID Multi-District Li  -  Dec 15, 2005
The Propulsid MDL court will post on its website located at "http:%5C\propulsid.laed.uscourts.gov," the Term Sheet and forms referenced in an Order to be ... Free with registration - PR Newswire - AccessMyLibrary.com

Aryx Therapeutics in Fremont signs huge deal with Procter & Gamble  -  Aug 18, 2006
Propulsid was pulled from the market in 2000 after generating close to $1 ... ATI-7505, the replacement for Propulsid, is the closest to market but even if ... East Bay Business Times

To the Editor:  -  Jun 23, 2005
You assert that the company underwrote promotion of Propulsid in children but do not reveal that the Food and Drug Administration had requested that it ... New York Times

$90m payout over child abuse drug  -  Jun 14, 2007
Now it has emerged that the United States-based Janssen Pharmaceutica, which markets cisapride under the brand name Propulsid, is to offer up to $90 million ... guardian.co.uk

Report: FDA lax on safety issues  -  Apr 25, 2006
...the rheumatoid arthritis drug Arava, and the nighttime heartburn medication Propulsid - and concluded that "there is a lack of criteria for determining ... Pay-Per-View - Newsday - ProQuest Archiver

Sutton v. St. Jude Medical SC, Inc., 419 F.3d 568, 2005 Fed.App....  -  Aug 23, 2005
In re Propulsid found that a plaintiff who had previously used a heartburn drug ... In re Propulsid, 208 FRD at 139 (citing Friends for All Children, ... $2.95 - U.S. Court of Appeals, Sixth Circuit - VersusLaw

Drug makers must warn patients of risks, Justices rule  -  Jun 28, 2007
Janssen, a subsidiary of Johnson & Johnson, manufactured Propulsid and supplied samples ... In 1999, Wilson prescribed Propulsid for patient Nancy Gellner. ... West Virginia Record

Mississippi Reports - WYETH-AYERST LABORATORIES v. CALDWELL, …  -  Jan 27, 2005
...sever fifty-six plaintiffs who brought claims against forty-two different doctors and the manufacturer of the drug Propulsid. Armond, 866 So.2d at 1095. ... Pay-Per-View - Mississippi Reports - Loislaw

United States: No Injury Lawsuits and Constitutional Standing to Sue...  -  Oct 28, 2005
Like Sutton, the plaintiff in In re Propulsid Products Liability Litigation did not claim to have suffered a physical injury as a result of her use of the ... Mondaq News Alerts - Mondaq News Alerts (Registration)

West Virginia Supreme Court Reports - STATE v. KARL, 220 W. Va. 463 (...  -  Jun 29, 2007
Propulsid® was manufactured and distributed by Janssen. In addition to prescribing Propulsid®, Dr. Wilson also provided Mrs. Gellner with samples of the ... Pay-Per-View - West Virginia Supreme Court Reports - Loislaw

Merck Faces A Crossroads In Vioxx Cases  -  Nov 7, 2005
Like Merck, Johnson & Johnson lost its first case over Propulsid, a heartburn medicine that was shown to increase risks of dangerous and sometimes fatal ... Subscription - Wall Street Journal Online - Dow Jones & Company

Press Release: WolfBlock Urges NJ Physicians to Opt Out of Sutter v. ...  -  Dec 4, 2006
Article: State court rejects propulsid class; plaintiff lawyers ... ... "Whereas the class members who initially took Propulsid ... clearly enough. ... Pay-Per-View - PR Newswire - HighBeam Research

Mississippi Reports - MS LIFE INS. CO. v. BAKER, 2003-IA-01149-SCT ( …  -  Jan 13, 2005
...fn5] Armond dealt with a case of fifty-six plaintiffs who brought claims against their doctors and the manufacturer of the drug Propulsid. Id. at 1095. ... Pay-Per-View - Mississippi Reports - Loislaw

Learned-intermediary doctrine rejected in West Virginia. | Article...  -  Sep 1, 2007
On May 19, 1999, Nancy Gellner began taking Propulsid to treat acid reflux. ... The FDA approved Propulsid in 1993 to treat heartburn. ... Pay-Per-View - Trial - HighBeam Research

Deroy Murdock on Medicine on National Review Online  -  Oct 19, 2005
Janssen Pharmaceutical's Propulsid treated heartburn and acid-reflux disease ... “People who need Propulsid have to cut through more red tape than a drug ... nationalreview.com

Lawsuit lunacy.(COMMENTARY)  -  Sep 17, 2006
When Hazel Norton of Mississippi read about a class-action suit filed on behalf of patients taking the prescription drug Propulsid, she thought, ... $4.95 - Washington Times - ECNext

Texas Case Law - LOW v. HENRY, 221 SW3d 609 (Tex. 2007)  -  Apr 20, 2007
Although most of the claims involved the drug Propulsid, some alleged that the physicians and hospital were negligent in Henry White's medical treatment. ... Pay-Per-View - Texas Case Law - Loislaw

Drug Makers Near Old Goal: A Legal Shield  -  Apr 6, 2008
In the last decade, suits over Zyprexa, the withdrawn pain pill Vioxx, the withdrawn diabetes medicine Rezulin, the withdrawn heartburn medicine Propulsid ... New York Times

ARYx Signs P&G To $435M Agreement For Lead GI Drug  -  Jul 13, 2006
ATI-7505 has the same mechanism of action as Propulsid, but does not appear to have the same safety issues because of its design, Nagler said. ... BioWorld Online - BioWorld Online

Brains Over Guts  -  Oct 22, 2008
In 2000 Johnson & Johnson's heartburn drug Propulsid, which was used as an off-label treatment for IBS, and GlaxoSmithkline's drug Lotronex were pulled from ... Forbes

P&G licenses reflux drug  -  Jul 18, 2006
P&G once sold another heartburn drug, blockbuster Propulsid (cisapride), but withdrew it in 2000 due to concerns over possible heart problems. ... Medical Marketing & Media - Medical Marketing and Media

Mississippi No Longer a Mass Tort Haven  -  Jan 14, 2005
In that case, which involved a Propulsid mass tort, ... "We hold today," it said, "that the prescribing of the drug Propulsid by 43 different physicians to ... Law.com

Senate committee to probe J&J's use of educational funds  -  Jul 5, 2005
The Senate Finance Committee has begun a probe into Johnson & Johnson's use of educational grants for physicians to promote Propulsid in the 1990s, ... FierceBiotech

Drugs Ease Hard-To-Treat Constipation  -  May 29, 2008
Resolor is in the same drug family as Propulsid and Zelnorm , both of which were taken off the market because they caused dangerous heart problems in some ... CBS News

Article: Santarus may find relief in '08 with sale of rights to...  -  Oct 30, 2006
The nighttime heartburn drug Propulsid should immediately be taken off the market because of new reports linking it to 23 additional deaths, the consumer ... Pay-Per-View - San Diego Business Journal - HighBeam Research

State ex rel Johnson & Johnson Corp. v. Karl, 647 SE2d 899, 220 W.Va....  -  Jun 27, 2007
Propulsid® was manufactured and distributed by Janssen. In addition to prescribing Propulsid®, Dr. Wilson also provided Mrs. Gellner with samples of the ... $2.95 - West Virginia Supreme Court of Appeals - VersusLaw

In re Fosamax Products Liability Litigation, No. 1:06-cv-6295 (SDNY...  -  Jan 3, 2008
Litig., 210 F.R.D. 61 (S.D.N.Y. 2002) (recalled diabetes drug); In re Propulsid Prods. Liab. Litig., 208 F.R.D. 133, 147, (E.D. La. ... $2.95 - U.S. District Court, Southern District... - VersusLaw

Lawyers Seek FDA Zelnorm Documents through Freedom of Information …  -  Feb 20, 2007
In 2000, digestive-system drugs Propulsid and Lotronex were also taken off the market. Propulsid was likewise found to cause heart problems. ... prleap.com

I believe scientists who call pesticides dangerous  -  Mar 29, 2005
...asbestos, trans fat, hormone replacement therapy, Vioxx, DDT, Seldane, Propulsid, fen phen -- and now pesticides according to extensive research. ... Pay-Per-View - The Record - ProQuest Archiver

Brains Over Guts.  -  Nov 10, 2008
In 2000 Johnson & Johnsons heartburn drug Propulsid, which was used as an off-label treatment for IBS, and GlaxoSmithklines drug Lotronex were pulled from ... $9.94 - Forbes - Alacra Store

FDA Is Criticized Over Drugs' Safety Problems  -  Apr 24, 2006
...the rheumatoid arthritis drug Arava, and the nighttime heartburn medication Propulsid -- and concluded that "there is a lack of criteria for determining ... Washington Post

Shenanigans of Corporate Grantmaking  -  May 11, 2007
When research linked Propulsid with dangerous heart arrhythmias in children, the toxic drug was withdrawn from the market and the supposedly independent ... The Nonprofit Quarterly

Drug maker obscured problems spotted in test Johnson & Johnson says …  -  Apr 7, 2008
In the last decade, suits over Zyprexa, the withdrawn pain pill Vioxx, the withdrawn diabetes medicine Rezulin, the withdrawn heartburn medicine Propulsid ... Pay-Per-View - International Herald Tribune - HighBeam Research

The FDA's Label Fix  -  Jan 18, 2006
A similar JAMA study from 2000 argued that new labeling for Propulsid, a withdrawn ulcer drug from Johnson & Johnson (nyse: JNJ - news - people ), also had ... Forbes

Bristol-Myers Squibb Extends Assistance to State AIDS Drug Assistance...  -  Mar 22, 2005
SUSTIVA should not be taken with Hismanal(R) (astemizole), Propulsid(R) (cisapride), Versed(R) (midazolam), Halcion(R) (triazolam), ergot medicines (for ... Free with registration - PR Newswire - AccessMyLibrary.com

Drugmakers Should Market Whatever They Wish, With Disclosure  -  Oct 6, 2005
Janssen Pharmaceutical's Propulsid treated heartburn and acid-reflux disease until its removal in 2000. This followed an FDA report of 80 deaths since ... RedOrbit

In re Vioxx Products Liability Litigation, 478 F.Supp.2d 897 (EDLa....  -  Mar 22, 2007
The Court reached the same conclusion in the Propulsid multidistrict ... See In re Propulsid Prods. Liab. Litig., 208 F.R.D. 133, 142-44 (E.D. La. ... $2.95 - U.S. District Court, Eastern District... - VersusLaw

Tranzyme Pharma mulls cash options to test drug  -  Oct 10, 2008
Garg says TZP-102 could fill the need vacated by Propulsid, a product developed by Johnson & Johnson subsidiary Janssen Pharmaceuticals that reached $1 ... Bizjournals.com

A new documentary takes aim at a dubious diagnosis  -  Mar 10, 2005
Propulsid has now been removed from the US market.) "I found incredible documentation of this issue," de la Pena says. "The child begins the drug, ... Dallas Observer

Rising Bond Rates and Falling Mortgage Rates Make a Puzzle for …  -  Jun 10, 2005
The saga of Propulsid, a heartburn medicine pulled from the market in 2000, illustrates the difficulty that the Food and Drug Administration has in ... New York Times

Aryx accelerates partner search after Procter & Gamble ends …  -  Jul 11, 2008
Johnson & Johnson's Propulsid was withdrawn from the US market in 2000 due to serious cardiovascular side effects. But Aryx was able to license ATI-7505, ... Bizjournals.com

Loislaw Federal District Court Opinions - IN RE GUIDANT CORP. …  -  May 22, 2007
In re Propulsid Prods. Liab. Litig., 208 FRD 133 , 140 (ED La. 2002). Here, Duron filed his original Complaint in California; however, he contends Minnesota ... Pay-Per-View - Loislaw Federal District Court Opinions - Loislaw

What's Next For Merck?  -  Aug 19, 2005
But plaintiffs' losses in early cases concerning other drugs, such as Propulsid, a Johnson & Johnson (nyse: JNJ - news - people ) ulcer drug, or PPA, ... Forbes

Senate Pharma Grants Probe  -  Sep 1, 2005
The Propulsid marketing campaign did not fall under the scope of the original letter, which asked for information dating back to 2000. ... Pay-Per-View - Medical Meetings - Factiva, from Dow Jones

No Injury Lawsuits and Constitutional Standing to Sue in Federal...  -  Oct 27, 2005
Like Sutton, the plaintiff in In re Propulsid Products Liability Litigation did not claim to have suffered a physical injury as a result of her use of the ... $9.94 - Mondaq Business Briefing - Alacra Store

DISCLOSE RISKS, BUT LET DRUG MAKERS SELL WHATEVER WORKS …  -  Oct 12, 2005
Janssen Pharmaceutical's Propulsid treated acid-reflux disease until its removal in 2000. This followed an FDA report of 80 deaths since Propulsid's 1993 ... $2.95 - Press of Atlantic City, The - NewsBank

Acetaminophen poisoning is on the increase | Article from The Record...  -  Dec 27, 2005
Article: PROPULSID WOES HURT J&J'S STOCK The Record (Bergen County, NJ); ... Propulsid has been linked to 80 deaths and 341 cases of heart rhythm ... ... Pay-Per-View - The Record - HighBeam Research

Business notebook  -  Jul 12, 2006
P&G will pay closely held Aryx Therapeutics for its safer version of Johnson & Johnson's Propulsid, which was removed from pharmacy shelves six years ago ... Boston Globe

Cleaveland: New meds may have big flaws  -  Jun 5, 2008
Vioxx, Rezulin, and Propulsid are recent examples of once popular prescription drugs that have been withdrawn because of adverse reactions that became ... Chattanooga Times Free Press

CHEMICAL FALLOUT; WATCHDOG REPORT UPDATE BPA substitutes …  -  Nov 1, 2008
FDA's drug approval process is coming under fire ... drug Propulsid were added to the list. "The FDA is acting in a reckless way to make sure they . ... Pay-Per-View - Milwaukee Journal Sentinel - HighBeam Research

Out-of-state Accutane claim reinstated in New Jersey. | Article from...  -  Jun 1, 2006
Article: State court rejects propulsid class; plaintiff lawyers . ... The New Jersey Propulsid case ... MDL. All allege products liability against Johnson ... Pay-Per-View - Trial - HighBeam Research

Drug warnings outline danger  -  Apr 25, 2005
The antihistamine Seldane, pain reliever Duract, heartburn drug Propulsid and diabetes drug Rezulin all came off the market because multiple revisions in ... USA Today

FDA Fix No. 5: Forget Labels  -  Jan 18, 2005
A similar 2000 study in JAMA found that FDA warnings had little effect on the use of Propulsid, a stomach pain drug made by Johnson & Johnson (nyse: JNJ ... Forbes

Deal for users of fen-phen opposed  -  Feb 18, 2005
...to handle the Vioxx litigation He is overseeing a proposed settlement related to Propulsid, a heartburn drug made by a Johnson & Johnson subsidiary. New York Times

CHEMICAL FALLOUT / A WATCHDOG REPORT UPDATE Scientists fault …  -  Oct 29, 2008
FDA's drug approval process is coming under fire ... drug Propulsid were added to the list. "The FDA is acting in a reckless way to make sure they . ... Pay-Per-View - Milwaukee Journal Sentinel - HighBeam Research

FDA Is Criticized Over Drugs' Safety Problems; Response to Approved …  -  Apr 24, 2006
...the rheumatoid arthritis drug Arava, and the nighttime heartburn medication Propulsid -- and concluded that "there is a lack of criteria for determining ... Pay-Per-View - Washington Post - HighBeam Research

US Stock-Index Futures Are Little Changed; Intel Shares Slip  -  Jun 10, 2005
The company continued to sell its drug Propulsid to treat heartburn even after dozens of patients had died and federal regulators told the company it may ... Bloomberg

Court award casts doubts on drug firms  -  Aug 28, 2005
Johnson & Johnson has already paid out €106m to settle cases brought by users of its heartburn drug Propulsid, withdrawn in 2000, though analysts reckon ... unison.ie

GERD and Reflux in Infants and Children  -  Sep 1, 2006
Propulsid. This drug was voluntarily withdrawn from the US market in 2000; however, it is still available with very limited access. ... WebMD

Medical News: Irritable Bowel Syndrome  -  Mar 30, 2007
In 2000, Janssen Pharmacetuical pulled cisapride (Propulsid) a gastrointestinal reflux drug that also gained popularity as a treatment for IBS-c, ... MedPage Today

Heartburn and Gastroesophageal Reflux Disease (GERD)  -  Mar 1, 2006
Another promotility agent, Propulsid, was removed from the market in 2000 because it caused serious heart arrythmias (abnormal heart beat) in some people. ... WebMD

Drug regulator to monitor side effects  -  Aug 26, 2007
Ceoxx and Ceeoxx; cisapride, one of the most prescribed heartburn drugs sold under the trade names Prepulsid (Janssen-Ortho) and Propulsid (in the US) ... Livemint

Sucampo's Amitiza Gets FDA Nod in IBS with Constipation  -  May 1, 2008
...is similar to cisapride, a 5-HT4 receptor agonist that was marketed as Propulsid by Johnson & Johnson until it was pulled from the shelves in 2000, ... BioWorld Online - BioWorld Online

MERCK SHARES KEEP TUMBLING IN AFTERMATH OF DAMAGES …  -  Aug 23, 2005
He cited examples including Johnson & Johnson, for heartburn drug Propulsid; Bayer AG, for cholesterol drug Baycol; former drugmaker Warner-Lambert, ... $2.95 - Press of Atlantic City, The - NewsBank

Diversification is J&J's vaccine  -  Mar 26, 2005
Propulsid, for severe heartburn, and the antihistamine Hismanal were found to increase risk of fatal, abnormal heart rhythms. ... $2.95 - Philadelphia Inquirer - NewsBank

J&J profit soars 79 pct., despite a dip in revenue.(Johnson and...  -  Jan 25, 2006
...at ... drug combination known as "fen-phen," Frazier did say that Johnson & Johnson's strategy in defense of its heartburn remedy Propulsid showed ... ... Pay-Per-View - Philadelphia Inquirer - HighBeam Research

[U] Sanders v. Johnson & Johnson, Inc., No. 03-2663 (DNJ 05/31/2006)  -  May 31, 2006
See In re Propulsid Prods. Liab. Litig., 208 F.R.D. 133, 147 (E.D. La. ... In re Propulsid Prods., 208 F.R.D. at 147. "'[T]he courtroom is not the place for ... $2.95 - U.S. District Court, District of New... - VersusLaw

Drug warnings too often ignored  -  Feb 1, 2006
The antihistamines Seldane and Hismanal and the heartburn medicine Propulsid disappeared due to interaction issues. Because thousands of people are injured ... $2.95 - Buffalo News - NewsBank

Deadly Painkiller The drug caused 2,000 deaths in the last two decades  -  Mar 1, 2006
Public Citizen has a reputation for identifying dangerous drugs; products such as Vioxx, Ephedra, Bextra, Rezulin, Baycol, Propulsid were found years before ... Softpedia

Can the FDA get its bite back?  -  May 9, 2006
...handling of four drugs with safety issues -- Arava for rheumatoid arthritis, Baycol for high cholesterol, Bextra for pain and Propulsid for acid reflux. ... $2.95 - Buffalo News - NewsBank

Short-term effect of domperidone on gastroesophageal reflux in...  -  Jun 26, 2008
A mechanism for the proarrhythmic effects of cisapride (Propulsid): high affinity blockade of the human cardiac potassium channel HERG. ... Nature.com

Mississippi Reports - WYETH LABORATORIES v. JAMES, 2003-IA-01255 …  -  Jun 30, 2005
In Armond, this Court found that the prescribing of Propulsid by 42 different doctors to 56 different patients "did not arise out of the same transaction, ... Pay-Per-View - Mississippi Reports - Loislaw

HOLIDAYS HEAT UP HEARTBURN.(Living) | Article from The Cincinnati …  -  Dec 14, 2007
The popular heartburn drug Propulsid, which has been associated with 80 deaths, will no longer be marketed after July, except in special circumstances ... ... Pay-Per-View - Cincinnati Post - HighBeam Research

Milwaukee Journal Sentinel : DRUG CAPSULE WHAT YOU SHOULD …  -  Sep 26, 2005
Interactions: Do not take Prozac with drugs such as astemizole (Hismanal); cisapride (Propulsid); pimozide (Orap); terfenadine (Seldane); ... $2.95 - Milwaukee Journal Sentinel - NewsBank

Article: FDA links eczema drugs to possibility of cancer - Deseret...  -  Mar 11, 2005
Propulsid has been linked to 70 deaths and more than 270 significant negative reactions since 1993, the Food and Drug Administration warned yesterday. ... Pay-Per-View - Deseret News - HighBeam Research

ANIMAL HOUSE, Bunnies' tummies can be at risk  -  Feb 26, 2007
Instead, veterinarians may intervene with oral or subcutaneous fluids; motility drugs such as Propulsid or Reglan to coax the intestines back into action; ... Pay-Per-View - Newsday - ProQuest Archiver

Article: DRUG CAPSULE WHAT YOU SHOULD KNOW - The Milwaukee …  -  Sep 26, 2005
Interactions: Do not take Prozac with drugs such as astemizole (Hismanal); cisapride (Propulsid); pimozide (Orap); terfenadine (Seldane); ... Pay-Per-View - Milwaukee Journal Sentinel - HighBeam Research

More prescription complaints against CVS  -  Jul 14, 2005
The baby's doctor first prescribed him Zantac, then added a drug called Propulsid. Polleck said the pharmacist gave her a bottle with instructions to give ... $2.95 - The Sun - NewsBank

Article: Smith's son on anti-depressants, 2nd autopsy says - Chicago...  -  Sep 19, 2006
Chicago Sun-Times; June 4, 2000 ; 700+ words ... ... cisapride (Propulsid) and cimetidine (Tagamet) prescribed therapy" and "trial drug study. ... Pay-Per-View - Chicago Sun-Times - HighBeam Research

Drugs withdrawn from the market since 1997*  -  Feb 16, 2005
Propulsid, a heartburn medication approved in 1993, was linked to heart rhythm abnormalities. A cholesterol-lowering medication approved in June 1997 is ... $2.95 - St. Louis Post-Dispatch - NewsBank

PANEL: COLD MEDICINES MAY HARM KIDS UNDER 6.(News) | Article …  -  Oct 20, 2007
Text of fax box follows ... or restricted by the FDA: Propulsid, a chronic ... Posicor, a blood pressure medicine. Redux, a diet drug ... ... Pay-Per-View - Cincinnati Post - HighBeam Research

Study: Docs keep improving until 250 surgeries | Article from Chicago...  -  Jul 29, 2007
The Food and Drug Administration is frustrated: There's a drug that kills people, yet doctors still prescribe it. The drug is called Propulsid, and it's ... ... Pay-Per-View - Chicago Sun-Times - HighBeam Research

Brand Names/Synonyms:
Propulsid is also known by the following brand names and/or synonymsAcenalin; Prepulsid; Propulsid; Propulsin; Alimix; Enteropride; Syspride; Pridesia; Kinestase; Cipril; Propulsid Quicksolv; R 51619; Risamal

Drug Category:
Propulsid is categorized under the following by the FDA: Gastrointestinal Agents; Anti-ulcer Agents; Prokinetic Agents; Serotonin Agonists; ATC:A03FA02

Dosage Forms:
SUSPENSION; TABLET

Absorption:
Cisapride is rapidly absorbed after oral administration. The absolute bioavailability of cisapride is 35-40%.

Interactions:
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Chemical IUPAC Name:
4-amino-5-chloro-N-[1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidyl]-2-methoxy-benzamide





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